gamma-Aminobutyric acid

Identification

Name
gamma-Aminobutyric acid
Accession Number
DB02530  (EXPT00402, DB08850)
Type
Small Molecule
Groups
Approved, Investigational
Description

The most common inhibitory neurotransmitter in the central nervous system.

Structure
Thumb
Synonyms
  • 4-aminobutanoic acid
  • 4-aminobutyric acid
  • 4Abu
  • GABA
  • gamma-Aminobutyric acid
  • piperidic acid
  • piperidinic acid
  • γ-amino-n-butyric acid
  • γ-aminobutanoic acid
  • γ-Aminobuttersäure
  • γ-aminobutyric acid
  • ω-aminobutyric acid
Product Ingredients
IngredientUNIICASInChI Key
Gamma-Aminobutyric Acid Hydrochloride0S3LEB8Q585959-35-3QPGLUEKHBNOAHG-UHFFFAOYSA-N
Unapproved/Other Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Gongjinhyang Qi and Jin EyeCream.022 mL/100mLTopicalLg Household & Health Care Ltd.2010-05-24Not applicableUs
Mixture Products
NameIngredientsDosageRouteLabellerMarketing StartMarketing End
Medi-doze Rx Sleep Aidgamma-Aminobutyric acid (30 mg/1) + Melatonin (6 mg/1) + Valerian (50 mg/1)TabletOralTwo Hip Consulting, Llc2013-02-202016-04-05Us
Therabenzaprine-60gamma-Aminobutyric acid + Cyclobenzaprine HydrochlorideKitPhysician Therapeutics Llc2011-05-152016-10-13Us
Therabenzaprine-90gamma-Aminobutyric acid + Cyclobenzaprine HydrochlorideKitPhysician Therapeutics Llc2011-02-162016-10-13Us
Therabenzaprine-90-5gamma-Aminobutyric acid + Cyclobenzaprine HydrochlorideKitPhysician Therapeutics Llc2011-02-152016-10-13Us
Theracodeine-300gamma-Aminobutyric acid + Acetaminophen + Codeine phosphateKitOralPhysician Therapeutics Llc2011-02-152016-10-13Us
Theracodophen-325gamma-Aminobutyric acid + Acetaminophen + Hydrocodone bitartrateKitPhysician Therapeutics Llc2011-02-082016-10-13Us
Theracodophen-650gamma-Aminobutyric acid + Acetaminophen + Hydrocodone bitartrateKitPhysician Therapeutics Llc2011-03-062016-10-13Us
Theracodophen-750gamma-Aminobutyric acid + Acetaminophen + HydrocodoneKitPhysician Therapeutics Llc2011-02-092016-10-13Us
Theracodophen-Low-90gamma-Aminobutyric acid + Acetaminophen + Hydrocodone bitartrateKitPhysician Therapeutics Llc2011-02-022016-10-13Us
Therafeldaminegamma-Aminobutyric acid + PiroxicamKitPhysician Therapeutics Llc2011-03-032016-10-13Us
Categories
Not Available
UNII
2ACZ6IPC6I
CAS number
56-12-2
Weight
Average: 103.1198
Monoisotopic: 103.063328537
Chemical Formula
C4H9NO2
InChI Key
BTCSSZJGUNDROE-UHFFFAOYSA-N
InChI
InChI=1S/C4H9NO2/c5-3-1-2-4(6)7/h1-3,5H2,(H,6,7)
IUPAC Name
4-aminobutanoic acid
SMILES
NCCCC(O)=O

Pharmacology

Indication
Not Available
Structured Indications
Not Available
Pharmacodynamics
Not Available
Mechanism of action
TargetActionsOrganism
UGlycine amidinotransferase, mitochondrialNot AvailableHuman
UGamma-aminobutyric acid type B receptor subunit 1Not AvailableHuman
UGamma-aminobutyric acid type B receptor subunit 2Not AvailableHuman
Absorption
Not Available
Volume of distribution
Not Available
Protein binding
Not Available
Metabolism
Not Available
Route of elimination
Not Available
Half life
Not Available
Clearance
Not Available
Toxicity
Not Available
Affected organisms
Not Available
Pathways
PathwayCategory
Succinic semialdehyde dehydrogenase deficiencyDisease
Glutamate MetabolismMetabolic
HomocarnosinosisDisease
2-Hydroxyglutric Aciduria (D And L Form)Disease
4-Hydroxybutyric Aciduria/Succinic Semialdehyde Dehydrogenase DeficiencyDisease
Hyperinsulinism-Hyperammonemia SyndromeDisease
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
Not Available
Food Interactions
Not Available

References

General References
Not Available
External Links
Human Metabolome Database
HMDB00112
KEGG Drug
D00058
KEGG Compound
C00334
PubChem Compound
119
PubChem Substance
46507841
ChemSpider
116
BindingDB
24183
ChEBI
59888
ChEMBL
CHEMBL96
IUPHAR
1067
Guide to Pharmacology
GtP Drug Page
HET
ABU
Wikipedia
Gamma-Aminobutyric_acid
PDB Entries
1m19 / 1m1a / 1qur / 1s32 / 2jt9 / 2okj / 2okk / 2yoe / 3ip9 / 3usu
show 14 more

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount
1RecruitingTreatmentType I Diabetes1
2WithdrawnTreatmentDiabetes Mellitus (DM)1
4RecruitingTreatmentPain1
Not AvailableRecruitingBasic SciencePain1
Not AvailableUnknown StatusTreatmentDiabetes, Diabetes Mellitus Type 11

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage forms
FormRouteStrength
CreamTopical.022 mL/100mL
TabletOral
KitOral
Kit
Prices
Not Available
Patents
Not Available

Properties

State
Solid
Experimental Properties
Not Available
Predicted Properties
PropertyValueSource
Water Solubility365.0 mg/mLALOGPS
logP-3ALOGPS
logP-2.9ChemAxon
logS0.55ALOGPS
pKa (Strongest Acidic)4.53ChemAxon
pKa (Strongest Basic)10.22ChemAxon
Physiological Charge0ChemAxon
Hydrogen Acceptor Count3ChemAxon
Hydrogen Donor Count2ChemAxon
Polar Surface Area63.32 Å2ChemAxon
Rotatable Bond Count3ChemAxon
Refractivity25.46 m3·mol-1ChemAxon
Polarizability10.62 Å3ChemAxon
Number of Rings0ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterNoChemAxon
Veber's RuleNoChemAxon
MDDR-like RuleNoChemAxon
Predicted ADMET features
PropertyValueProbability
Human Intestinal Absorption+0.9258
Blood Brain Barrier+0.9117
Caco-2 permeable-0.6516
P-glycoprotein substrateNon-substrate0.7407
P-glycoprotein inhibitor INon-inhibitor0.9819
P-glycoprotein inhibitor IINon-inhibitor0.9677
Renal organic cation transporterNon-inhibitor0.8182
CYP450 2C9 substrateNon-substrate0.8751
CYP450 2D6 substrateNon-substrate0.7724
CYP450 3A4 substrateNon-substrate0.7728
CYP450 1A2 substrateNon-inhibitor0.9495
CYP450 2C9 inhibitorNon-inhibitor0.9641
CYP450 2D6 inhibitorNon-inhibitor0.9786
CYP450 2C19 inhibitorNon-inhibitor0.9777
CYP450 3A4 inhibitorNon-inhibitor0.942
CYP450 inhibitory promiscuityLow CYP Inhibitory Promiscuity0.9821
Ames testNon AMES toxic0.8858
CarcinogenicityNon-carcinogens0.7416
BiodegradationReady biodegradable0.9414
Rat acute toxicity1.1546 LD50, mol/kg Not applicable
hERG inhibition (predictor I)Weak inhibitor0.9362
hERG inhibition (predictor II)Non-inhibitor0.9322
ADMET data is predicted using admetSAR, a free tool for evaluating chemical ADMET properties. (23092397)

Spectra

Mass Spec (NIST)
Not Available
Spectra
SpectrumSpectrum TypeSplash Key
GC-MS Spectrum - GC-EI-TOF (Pegasus III TOF-MS system, Leco; GC 6890, Agilent Technologies) (3 TMS)GC-MSsplash10-00dj-1900000000-f831f79dfcaeffa8b177
GC-MS Spectrum - GC-EI-TOF (Pegasus III TOF-MS system, Leco; GC 6890, Agilent Technologies) (3 TMS)GC-MSsplash10-00di-1900000000-2de9d92a2cfc7bc655f4
GC-MS Spectrum - GC-EI-TOF (Pegasus III TOF-MS system, Leco; GC 6890, Agilent Technologies) (3 TMS)GC-MSsplash10-00di-1900000000-73bbf2ee0803f058dbed
GC-MS Spectrum - GC-EI-TOF (Pegasus III TOF-MS system, Leco; GC 6890, Agilent Technologies) (3 TMS)GC-MSsplash10-00di-1901000000-85d4bd98af8534428b5a
GC-MS Spectrum - GC-EI-TOF (Pegasus III TOF-MS system, Leco; GC 6890, Agilent Technologies) (3 TMS)GC-MSsplash10-00di-0900000000-6be23968e972a414be51
GC-MS Spectrum - GC-EI-TOF (Pegasus III TOF-MS system, Leco; GC 6890, Agilent Technologies)GC-MSsplash10-00di-1900000000-9a224763afd8ca892add
GC-MS Spectrum - GC-EI-TOF (Pegasus III TOF-MS system, Leco; GC 6890, Agilent Technologies) (3 TMS)GC-MSsplash10-00di-9800000000-d8906d09ca1872a6391c
GC-MS Spectrum - GC-MS (2 TMS)GC-MSsplash10-0udi-1900000000-54db7e21790401045519
GC-MS Spectrum - GC-MS (3 TMS)GC-MSsplash10-00di-1901000000-b047af158215c2b5b8e8
Predicted GC-MS Spectrum - GC-MSPredicted GC-MSNot Available
GC-MS Spectrum - EI-BGC-MSsplash10-001i-9000000000-21ea76dfb0da62031f1d
GC-MS Spectrum - EI-BGC-MSsplash10-00di-0901000000-5d60b0a446fd8122f613
GC-MS Spectrum - GC-EI-TOFGC-MSsplash10-00dj-1900000000-f831f79dfcaeffa8b177
GC-MS Spectrum - GC-EI-TOFGC-MSsplash10-00di-1900000000-2de9d92a2cfc7bc655f4
GC-MS Spectrum - GC-EI-TOFGC-MSsplash10-00di-1900000000-73bbf2ee0803f058dbed
GC-MS Spectrum - GC-EI-TOFGC-MSsplash10-00di-1901000000-85d4bd98af8534428b5a
GC-MS Spectrum - GC-EI-TOFGC-MSsplash10-00di-0900000000-6be23968e972a414be51
GC-MS Spectrum - GC-EI-TOFGC-MSsplash10-00di-1900000000-9a224763afd8ca892add
GC-MS Spectrum - GC-EI-TOFGC-MSsplash10-00di-9800000000-d8906d09ca1872a6391c
GC-MS Spectrum - GC-MSGC-MSsplash10-0udi-1900000000-54db7e21790401045519
GC-MS Spectrum - GC-MSGC-MSsplash10-00di-1901000000-b047af158215c2b5b8e8
GC-MS Spectrum - GC-EI-TOFGC-MSsplash10-00dj-1900000000-1219470a0be188da64e6
GC-MS Spectrum - GC-EI-TOFGC-MSsplash10-0udi-0900000000-f7117dfaf9d856c95919
GC-MS Spectrum - GC-EI-TOFGC-MSsplash10-0006-1900000000-e35585a985d8128d044e
Mass Spectrum (Electron Ionization)MSsplash10-001i-9000000000-dbf4f9e19a35f953a189
MS/MS Spectrum - Quattro_QQQ 10V, Positive (Annotated)LC-MS/MSsplash10-0uxr-8900000000-ce0d8f44422836cd9965
MS/MS Spectrum - Quattro_QQQ 25V, Positive (Annotated)LC-MS/MSsplash10-0005-9000000000-8ce5afb97d7c08821da3
MS/MS Spectrum - Quattro_QQQ 40V, Positive (Annotated)LC-MS/MSsplash10-0005-9100000000-32c433b2c916697690f8
LC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , PositiveLC-MS/MSsplash10-0udi-0900000000-5831aaabdf53f3132ae5
LC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , PositiveLC-MS/MSsplash10-0a4i-9000000000-9babfd4a6937ecba7318
LC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , PositiveLC-MS/MSsplash10-0a4i-9000000000-e1c0c1485d846e9b123b
LC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , PositiveLC-MS/MSsplash10-0udi-0900000000-647d55ecf98850e7a875
LC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , PositiveLC-MS/MSsplash10-0udi-0900000000-7c107641a38922c88fca
LC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , PositiveLC-MS/MSsplash10-000i-9000000000-86718b349efad6334e3a
LC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , PositiveLC-MS/MSsplash10-000i-9000000000-a1e84e55e4b6c6628d5d
LC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , PositiveLC-MS/MSsplash10-0006-0009000000-29c22bf0ed844d09c0af
LC-MS/MS Spectrum - LC-ESI-QQ (API3000, Applied Biosystems) 10V, NegativeLC-MS/MSsplash10-0udi-0900000000-1d00adad47e42c60c340
LC-MS/MS Spectrum - LC-ESI-QQ (API3000, Applied Biosystems) 20V, NegativeLC-MS/MSsplash10-0udi-1900000000-47b195fb74720cc99464
LC-MS/MS Spectrum - LC-ESI-QQ (API3000, Applied Biosystems) 30V, NegativeLC-MS/MSsplash10-001i-9000000000-a14a52dc59bf9988bb44
LC-MS/MS Spectrum - LC-ESI-QQ (API3000, Applied Biosystems) 10V, PositiveLC-MS/MSsplash10-0udi-5900000000-20c55b2809389d5ad83b
LC-MS/MS Spectrum - LC-ESI-QQ (API3000, Applied Biosystems) 20V, PositiveLC-MS/MSsplash10-000i-9000000000-eca4c5aefca98751a11e
LC-MS/MS Spectrum - LC-ESI-QQ (API3000, Applied Biosystems) 30V, PositiveLC-MS/MSsplash10-014j-9000000000-f0783316e09291749409
LC-MS/MS Spectrum - LC-ESI-QQ (API3000, Applied Biosystems) 40V, PositiveLC-MS/MSsplash10-0005-9000000000-81837eb9c0b926cb0e81
LC-MS/MS Spectrum - LC-ESI-QQ (API3000, Applied Biosystems) 50V, PositiveLC-MS/MSsplash10-0005-9000000000-8b48126992d7fa242636
LC-MS/MS Spectrum - LC-ESI-QTOF (UPLC Q-Tof Premier, Waters) , PositiveLC-MS/MSsplash10-000i-9000000000-7d4636efbc4e5d75872e
Predicted MS/MS Spectrum - 10V, Positive (Annotated)Predicted LC-MS/MSsplash10-000i-9100000000-655f9d93a35bfa537583
Predicted MS/MS Spectrum - 20V, Positive (Annotated)Predicted LC-MS/MSsplash10-00ku-9000000000-4a334d5e272576f62403
Predicted MS/MS Spectrum - 40V, Positive (Annotated)Predicted LC-MS/MSsplash10-0006-9000000000-4a13b03446b3370ccd43
Predicted MS/MS Spectrum - 10V, Positive (Annotated)Predicted LC-MS/MSsplash10-000i-9100000000-655f9d93a35bfa537583
Predicted MS/MS Spectrum - 20V, Positive (Annotated)Predicted LC-MS/MSsplash10-00ku-9000000000-4a334d5e272576f62403
Predicted MS/MS Spectrum - 40V, Positive (Annotated)Predicted LC-MS/MSsplash10-0006-9000000000-4a13b03446b3370ccd43
Predicted MS/MS Spectrum - 10V, Positive (Annotated)Predicted LC-MS/MSsplash10-000i-9100000000-655f9d93a35bfa537583
Predicted MS/MS Spectrum - 20V, Positive (Annotated)Predicted LC-MS/MSsplash10-00ku-9000000000-4a334d5e272576f62403
Predicted MS/MS Spectrum - 40V, Positive (Annotated)Predicted LC-MS/MSsplash10-0006-9000000000-4a13b03446b3370ccd43
Predicted MS/MS Spectrum - 10V, Negative (Annotated)Predicted LC-MS/MSsplash10-0udi-4900000000-eb65b0fdb422ba9d9a2b
Predicted MS/MS Spectrum - 20V, Negative (Annotated)Predicted LC-MS/MSsplash10-0zgi-9400000000-0c816165ce1e099419c4
Predicted MS/MS Spectrum - 40V, Negative (Annotated)Predicted LC-MS/MSsplash10-052f-9000000000-3eb50b46056be2f20a58
Predicted MS/MS Spectrum - 10V, Negative (Annotated)Predicted LC-MS/MSsplash10-0udi-4900000000-eb65b0fdb422ba9d9a2b
Predicted MS/MS Spectrum - 20V, Negative (Annotated)Predicted LC-MS/MSsplash10-0zgi-9400000000-0c816165ce1e099419c4
Predicted MS/MS Spectrum - 40V, Negative (Annotated)Predicted LC-MS/MSsplash10-052f-9000000000-3eb50b46056be2f20a58
Predicted MS/MS Spectrum - 10V, Negative (Annotated)Predicted LC-MS/MSsplash10-0udi-4900000000-eb65b0fdb422ba9d9a2b
Predicted MS/MS Spectrum - 20V, Negative (Annotated)Predicted LC-MS/MSsplash10-0zgi-9400000000-0c816165ce1e099419c4
Predicted MS/MS Spectrum - 40V, Negative (Annotated)Predicted LC-MS/MSsplash10-052f-9000000000-3eb50b46056be2f20a58
LC-MS/MS Spectrum - LC-ESI-QQ , negativeLC-MS/MSsplash10-0udi-0900000000-1d00adad47e42c60c340
LC-MS/MS Spectrum - LC-ESI-QQ , negativeLC-MS/MSsplash10-0udi-1900000000-d8ff5f7f2b000a2455d5
LC-MS/MS Spectrum - LC-ESI-QQ , negativeLC-MS/MSsplash10-001i-9000000000-a14a52dc59bf9988bb44
MS/MS Spectrum - , negativeLC-MS/MSsplash10-0udi-1900000000-cf22f0f1cb463112f455
MS/MS Spectrum - , negativeLC-MS/MSsplash10-0udi-0900000000-27785600db8d1dd60f65
LC-MS/MS Spectrum - LC-ESI-QQ , positiveLC-MS/MSsplash10-0udi-5900000000-c8c55b5a6abccc85a5e2
LC-MS/MS Spectrum - LC-ESI-QQ , positiveLC-MS/MSsplash10-000i-9000000000-eca4c5aefca98751a11e
LC-MS/MS Spectrum - LC-ESI-QQ , positiveLC-MS/MSsplash10-014j-9000000000-f0783316e09291749409
LC-MS/MS Spectrum - LC-ESI-QQ , positiveLC-MS/MSsplash10-0005-9000000000-7da11b34d3bda6932394
LC-MS/MS Spectrum - LC-ESI-QQ , positiveLC-MS/MSsplash10-0005-9000000000-8b48126992d7fa242636
LC-MS/MS Spectrum - LC-ESI-ITFT , positiveLC-MS/MSsplash10-0a4i-9000000000-9babfd4a6937ecba7318
LC-MS/MS Spectrum - LC-ESI-ITFT , positiveLC-MS/MSsplash10-0a4i-9000000000-0154dce35de7f8820ebe
LC-MS/MS Spectrum - LC-ESI-ITFT , positiveLC-MS/MSsplash10-000i-9000000000-86718b349efad6334e3a
LC-MS/MS Spectrum - LC-ESI-QTOF , positiveLC-MS/MSsplash10-000i-9000000000-7d4636efbc4e5d75872e
MS/MS Spectrum - Linear Ion Trap , positiveLC-MS/MSsplash10-000i-9000000000-73e7e15a1b7cb86f1f7f
MS/MS Spectrum - , positiveLC-MS/MSsplash10-000i-9200000000-798d6fe6d2e79765073c
1H NMR Spectrum1D NMRNot Applicable
13C NMR Spectrum1D NMRNot Applicable
1H NMR Spectrum1D NMRNot Applicable
13C NMR Spectrum1D NMRNot Applicable
1H NMR Spectrum1D NMRNot Applicable
[1H,13C] 2D NMR Spectrum2D NMRNot Applicable

Taxonomy

Description
This compound belongs to the class of organic compounds known as gamma amino acids and derivatives. These are amino acids having a (-NH2) group attached to the gamma carbon atom.
Kingdom
Organic compounds
Super Class
Organic acids and derivatives
Class
Carboxylic acids and derivatives
Sub Class
Amino acids, peptides, and analogues
Direct Parent
Gamma amino acids and derivatives
Alternative Parents
Amino fatty acids / Straight chain fatty acids / Amino acids / Monocarboxylic acids and derivatives / Carboxylic acids / Organopnictogen compounds / Organic oxides / Monoalkylamines / Hydrocarbon derivatives / Carbonyl compounds
Substituents
Gamma amino acid or derivatives / Amino fatty acid / Straight chain fatty acid / Fatty acid / Fatty acyl / Amino acid / Monocarboxylic acid or derivatives / Carboxylic acid / Organic oxide / Organopnictogen compound
Molecular Framework
Aliphatic acyclic compounds
External Descriptors
monocarboxylic acid, gamma-amino acid (CHEBI:16865) / Amino fatty acids, Other amino acids, Biogenic amines (C00334) / Amino fatty acids (LMFA01100039)

Targets

Kind
Protein
Organism
Human
Pharmacological action
Unknown
General Function
Glycine amidinotransferase activity
Specific Function
Catalyzes the biosynthesis of guanidinoacetate, the immediate precursor of creatine. Creatine plays a vital role in energy metabolism in muscle tissues. May play a role in embryonic and central ner...
Gene Name
GATM
Uniprot ID
P50440
Uniprot Name
Glycine amidinotransferase, mitochondrial
Molecular Weight
48455.01 Da
References
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284]
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
General Function
G-protein coupled gaba receptor activity
Specific Function
Component of a heterodimeric G-protein coupled receptor for GABA, formed by GABBR1 and GABBR2. Within the heterodimeric GABA receptor, only GABBR1 seems to bind agonists, while GABBR2 mediates coup...
Gene Name
GABBR1
Uniprot ID
Q9UBS5
Uniprot Name
Gamma-aminobutyric acid type B receptor subunit 1
Molecular Weight
108319.4 Da
References
  1. Olianas MC, Ambu R, Garau L, Onali P: Allosteric modulation of GABA(B) receptor function in human frontal cortex. Neurochem Int. 2005 Jan;46(2):149-58. [PubMed:15627515]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
General Function
G-protein coupled gaba receptor activity
Specific Function
Component of a heterodimeric G-protein coupled receptor for GABA, formed by GABBR1 and GABBR2. Within the heterodimeric GABA receptor, only GABBR1 seems to bind agonists, while GABBR2 mediates coup...
Gene Name
GABBR2
Uniprot ID
O75899
Uniprot Name
Gamma-aminobutyric acid type B receptor subunit 2
Molecular Weight
105820.52 Da
References
  1. Olianas MC, Ambu R, Garau L, Onali P: Allosteric modulation of GABA(B) receptor function in human frontal cortex. Neurochem Int. 2005 Jan;46(2):149-58. [PubMed:15627515]

Transporters

Kind
Protein
Organism
Human
Pharmacological action
Unknown
General Function
L-proline transmembrane transporter activity
Specific Function
Neutral amino acid/proton symporter. Has a pH-dependent electrogenic transport activity for small amino acids such as glycine, alanine and proline. Besides small apolar L-amino acids, it also recog...
Gene Name
SLC36A1
Uniprot ID
Q7Z2H8
Uniprot Name
Proton-coupled amino acid transporter 1
Molecular Weight
53075.045 Da
References
  1. Thwaites DT, Basterfield L, McCleave PM, Carter SM, Simmons NL: Gamma-Aminobutyric acid (GABA) transport across human intestinal epithelial (Caco-2) cell monolayers. Br J Pharmacol. 2000 Feb;129(3):457-64. [PubMed:10711343]

Drug created on June 13, 2005 07:24 / Updated on November 09, 2017 03:15