Displaying drugs 3601 - 3625 of 11736 in total
Momelotinib
Momelotinib is a Janus Kinase 1 (JAK1) and 2 (JAK2) inhibitor. It is a competitive inhibitor of JAK ATP binding. First approved by the FDA on September 15, 2023, momelotinib is used to treat myelofibrosis. Myelofibrosis (MF) is a group of myeloproliferative neoplasms characterized by abnormal proliferative hematopoietic stem cells,...
Approved
Investigational
Matched Description: … It is a competitive inhibitor of JAK ATP binding. ... Momelotinib is a Janus Kinase 1 (JAK1) and 2 (JAK2) inhibitor. ... [L48186] Myelofibrosis (MF) is a group of myeloproliferative neoplasms characterized by abnormal proliferative …
Atractylodes lancea root oil
Atractylodes lancea root oil is a plant/plant extract used in some OTC (over-the-counter) products. It is not an approved drug.
Approved
Experimental
Matched Description: … Atractylodes lancea root oil is a plant/plant extract used in some OTC (over-the-counter) products. …
Human adenovirus b serotype 7
Human adenovirus b serotype 7 is a vaccine.
Approved
Matched Description: … Human adenovirus b serotype 7 is a vaccine. …
Netupitant
Netupitant is an antiemitic drug approved by the FDA in October 2014 for use in combination with palonosetron for the prevention of acute and delayed vomiting and nausea associated with cancer chemotherapy including highly emetogenic chemotherapy. Netupitant is a neurokinin 1 receptor antagonist. The combination drug is marketed by Eisai...
Approved
Investigational
Matched Description: … Netupitant is a neurokinin 1 receptor antagonist. …
Givinostat
Givinostat is a small molecule histone deacetylase (HDAC) inhibitor. It has been investigated as a treatment for a variety of inflammatory diseases, like Crohn's disease and juvenile idiopathic arthritis, cancers like leukemia and lymphoma, as well as several muscular dystrophies. In the context of muscular dystrophy, inhibitors of HDAC appear...
Approved
Investigational
Matched Description: … It has been investigated as a treatment for a variety of inflammatory diseases, like Crohn's disease ... Givinostat is a small molecule histone deacetylase (HDAC) inhibitor. …
Scopolamine
Scopolamine is a tropane alkaloid isolated from members of the Solanaceae family of plants, similar to atropine and hyoscyamine, all of which structurally mimic the natural neurotransmitter acetylcholine.[A228423, A228763] Scopolamine was first synthesized in 1959, but to date, synthesis remains less efficient than extracting scopolamine from plants. As an acetylcholine...
Approved
Investigational
Matched Description: … Scopolamine is a tropane alkaloid isolated from members of the _Solanaceae_ family of plants, similar ... [A228423, A228758] As a result of its anticholinergic effects, scopolamine is being investigated for ... to its dose-dependent adverse effects, scopolamine was the first drug to be offered commercially as a …
Tegaserod
Novartis' brand name Zelnorm (tegaserod) had originally received approval from the US FDA in 2002 for the treatment of irritable bowel syndrome with constipation (IBS-C).[L5918,F4229] It was, however, voluntarily withdrawn from widespread use in the US market in 2007 after concerns arose over the possibility that tegaserod could potentially cause...
Approved
Investigational
Withdrawn
Matched Description: … lower risk of a cardiovascular event than the broader population. ... of IBS-C specifically in female patients less than 65 years of age and whom are considered to be at a …
Diloxanide furoate
Approved
Medrogestone
Medrogestone (INN), also known as 6,17α-dimethyl-6-dehydroprogesterone, is a progestational agent derived from 17-methylprogesterone. It was conceived as an alternative for an orally effective contraceptive option. It was developed by Ayerst, approved in Canada in 1969 and its current status is cancelled post-marketing. It was never approved by the FDA.
Approved
Withdrawn
Matched Description: … Medrogestone (INN), also known as 6,17α-dimethyl-6-dehydroprogesterone, is a progestational agent derived …
Lepirudin
Lepirudin is a recombinant hirudin formed by 65 amino acids that acts as a highly specific and direct thrombin inhibitor.[L41539,L41569] Natural hirudin is an endogenous anticoagulant found in Hirudo medicinalis leeches. Lepirudin is produced in yeast cells and is identical to natural hirudin except for the absence of sulfate on...
Approved
Withdrawn
Matched Description: … Lepirudin is a recombinant hirudin formed by 65 amino acids that acts as a highly specific and direct ... anticoagulant in patients with heparin-induced thrombocytopenia (HIT), an immune reaction associated with a …
Venlafaxine
Venlafaxine is an antidepressant and a serotonin and norepinephrine reuptake inhibitor (SNRI). Its active metabolite, desvenlafaxine, works by blocking the reuptake of serotonin and norepinephrine, which are key neurotransmitters in mood regulation. Venlafaxine is officially approved to treat major depressive disorder (MDD), generalized anxiety disorder (GAD), social anxiety disorder, and...
Approved
Matched Description: … Venlafaxine is an antidepressant and a serotonin and norepinephrine reuptake inhibitor (SNRI). ... It was also considered a second-line treatment for obsessive-compulsive disorder (OCD). ... [A252065]
Venlafaxine has been used as a first-line treatment for MDD, GAD, social anxiety disorder …
Domiphen
Domiphen bromide is a quaternary ammonium compound that is predominantly employed as a topically administered antiseptic agent.
Approved
Experimental
Matched Description: … Domiphen bromide is a quaternary ammonium compound that is predominantly employed as a topically administered …
Tazemetostat
Tazemetostat is a methyltransferase inhibitor used to treat metastatic or locally advanced epithelioid sarcoma not eligible for complete resection. Tazemetostat was first named in literature as EPZ-6438. Tazemetaostat was granted FDA approval on 23 January 2020.
Approved
Investigational
Matched Description: … Tazemetostat is a methyltransferase inhibitor used to treat metastatic or locally advanced epithelioid …
Ipilimumab
Ipilimumab is a fully humanized IgG1 monoclonal antibody that blocks cytotoxic T lymphocyte antigen-4 (CTLA-4). Blocking CTLA-4 removes an inhibitory signal from reducing the activity of T lymphocytes.[A35065,A35080,L12126] Ipilimumab was developed by Bristol-Myers Squibb and Medarex. Ipilimumab was granted FDA approval on 25 March 2011.
Approved
Matched Description: … Ipilimumab is a fully humanized IgG1 monoclonal antibody that blocks cytotoxic T lymphocyte antigen-4 …
Influenza B virus B/Austria/1359417/2021 BVR-26 hemagglutinin antigen (formaldehyde inactivated)
A seasonally-specific component of the influenza vaccine. The influenza vaccine, also known as the "flu shot", is a vaccine that helps to protect against infection from influenza viruses. These vaccines provide protection from influenza by exposing the immune system to the virus (or parts of the virus) which results in...
Approved
Matched Description: … A seasonally-specific component of the influenza vaccine. ... The influenza vaccine, also known as the "flu shot", is a vaccine that helps to protect against infection ... Inactivated vaccines contain a virus particle that has been grown in media and then subsequently killed …
Duvelisib
Duvelisib, also known as IPI-145 and INK-1197, is a small-molecule inhibitor of phosphoinositide-3 kinases that was designed initially to prove that simultaneous inhibition of the isoforms delta and gamma can produce a broad adaptative and innate immune cell inhibitory activity. All the work around duvelisib showed that this agent is...
Approved
Investigational
Matched Description: … All the work around duvelisib showed that this agent is a potent inhibitor of both forms. ... Duvelisib, also known as IPI-145 and INK-1197, is a small-molecule inhibitor of phosphoinositide-3 kinases ... designed initially to prove that simultaneous inhibition of the isoforms delta and gamma can produce a …
Miocamycin
Miocamycin is a macrolide type antimicrobial . This drug may be marketed in Japan for clinical use as it is listed in the Japanese pharmacopeia . It has shown to be effective against several gram-positive and gram-negative microbes and may be useful in the treatment of upper and lower respiratory...
Approved
Matched Description: … Miocamycin is a macrolide type antimicrobial [A176170]. …
Rabeprazole
Rabeprazole is an antiulcer drug in the class of proton pump inhibitors. It is a prodrug - in the acid environment of the parietal cells it turns into active sulphenamide form. Rabeprazole inhibits the H+, K+ATPase of the coating gastric cells and dose-dependent oppresses basal and stimulated gastric acid secretion.
Approved
Investigational
Matched Description: … It is a prodrug - in the acid environment of the parietal cells it turns into active sulphenamide form …
Ambrosia psilostachya pollen
Ambrosia psilostachya pollen is the pollen of the Ambrosia psilostachya plant. Ambrosia psilostachya pollen is mainly used in allergenic testing.
Approved
Artemisia ludoviciana pollen
Artemisia ludoviciana pollen is the pollen of the Artemisia ludoviciana plant. Artemisia ludoviciana pollen is mainly used in allergenic testing.
Approved
Betula alleghaniensis pollen
Betula alleghaniensis pollen is the pollen of the Betula alleghaniensis plant. Betula alleghaniensis pollen is mainly used in allergenic testing.
Approved
Selenium Sulfide
Selenium Sulfide is an antifungal agent as well as a cytostatic agent, slowing the growth of hyperproliferative cells in seborrhea. Selenium Sulfide is the active ingredient often used in shampoos for the treatment of dandruff, seborrheic dermatitis and tinea capitis, a fungal infection that is primarily a disease of preadolescent...
Approved
Matched Description: … fungal infection that is primarily a disease of preadolescent children. ... Selenium Sulfide is an antifungal agent as well as a cytostatic agent, slowing the growth of hyperproliferative ... ingredient often used in shampoos for the treatment of dandruff, seborrheic dermatitis and tinea capitis, a …
Ximelagatran
Ximelagatran is an anticoagulant intended to become a replacement for warfarin by overcoming the dietary restrictions, drug interaction, and monitoring issues associated with the former. In 2006, its manufacturer AstraZeneca announced that it would not attempt to market ximelagatran after reports of hepatotoxicity (liver damage) during trials, and to discontinue...
Approved
Investigational
Withdrawn
Matched Description: … Ximelagatran is an anticoagulant intended to become a replacement for warfarin by overcoming the dietary …
Selinexor
Selinexor is a first-in-class selective inhibitor of nuclear transport (SINE) compound. Selinexor, in combination with bortezomib and dexamethasone, is currently approved for the treatment of multiple myeloma, a type of cancer formed from antibody-producing plasma cells.[L7117,L7120,L10145] This condition is typically treated with high dose bortezomib and dexamethasone chemotherapy followed by...
Approved
Investigational
Matched Description: … Selinexor is a first-in-class selective inhibitor of nuclear transport (SINE) compound. ... with [bortezomib] and [dexamethasone], is currently approved for the treatment of multiple myeloma, a …
Rivaroxaban
Rivaroxaban is an anticoagulant and the first orally active direct factor Xa inhibitor. Unlike warfarin, routine lab monitoring of INR is not necessary. However there is no antidote available in the event of a major bleed. Only the 10 mg tablet can be taken without regard to food. The 15...
Approved
Matched Description: … However there is no antidote available in the event of a major bleed. …
Displaying drugs 3601 - 3625 of 11736 in total