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Identification
NameVenlafaxine
Accession NumberDB00285  (APRD00125)
TypeSmall Molecule
GroupsApproved
DescriptionVenlafaxine (Effexor) is an antidepressant of the serotonin-norepinephrine reuptake inhibitor (SNRI) class first introduced by Wyeth in 1993. It is prescribed for the treatment of clinical depression and anxiety disorders. Due to the pronounced side effects and suspicions that venlafaxine may significantly increase the risk of suicide it is not recommended as a first line treatment of depression. However, it is often effective for depression not responding to SSRIs. Venlafaxine was the sixth most widely-used antidepressant based on the amount of retail prescriptions in the US (17.1 million) in 2006. [Wikipedia]
Structure
Thumb
Synonyms
Elafax
Venlafaxina
Venlafaxine
Venlafaxinum
External Identifiers Not Available
Approved Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Act Venlafaxine XRCapsule, extended release37.5 mgOralActavis Pharma Company2008-02-13Not applicableCanada
Act Venlafaxine XRCapsule, extended release75.0 mgOralActavis Pharma Company2008-02-13Not applicableCanada
Act Venlafaxine XRCapsule, extended release150.0 mgOralActavis Pharma Company2008-02-13Not applicableCanada
Auro-venlafaxine XRCapsule, extended release37.5 mgOralAuro Pharma Inc2016-03-14Not applicableCanada
Auro-venlafaxine XRCapsule, extended release75 mgOralAuro Pharma Inc2016-03-14Not applicableCanada
Auro-venlafaxine XRCapsule, extended release150 mgOralAuro Pharma Inc2016-03-14Not applicableCanada
Dom-venlafaxine XRCapsule, extended release150 mgOralDominion Pharmacal2013-05-30Not applicableCanada
Dom-venlafaxine XRCapsule, extended release37.5 mgOralDominion Pharmacal2013-05-23Not applicableCanada
Dom-venlafaxine XRCapsule, extended release75 mgOralDominion Pharmacal2013-05-23Not applicableCanada
Effexor Tablets, 37.5mgTablet37.5 mgOralWyeth Canada1994-12-312004-08-19Canada
Effexor Tablets, 50mgTablet50 mgOralWyeth Canada1995-12-312004-08-19Canada
Effexor Tablets, 75mgTablet75 mgOralWyeth Canada1994-12-312004-08-19Canada
Effexor XRCapsule, extended release150 mg/1OralLake Erie Medical DBA Quality Care Products LLC2011-05-25Not applicableUs
Effexor XRCapsule, extended release37.5 mg/1OralStat Rx USA1997-11-01Not applicableUs
Effexor XRCapsule, extended release37.5 mg/1OralCardinal Health1997-11-01Not applicableUs
Effexor XRCapsule, extended release75 mg/1OralWyeth Pharmaceuticals Inc., a subsidiary of Pfizer Inc.1997-11-01Not applicableUs
Effexor XRCapsule, extended release75 mg/1OralPhysicians Total Care, Inc.2003-04-25Not applicableUs
Effexor XRCapsule, extended release75 mg/1OralStat Rx USA1997-11-01Not applicableUs
Effexor XRCapsule, extended release150 mg/1OralCardinal Health1997-11-01Not applicableUs
Effexor XRCapsule, extended release150 mg/1OralWyeth Pharmaceuticals Inc., a subsidiary of Pfizer Inc.1997-11-01Not applicableUs
Effexor XRCapsule, extended release37.5 mgOralPfizer Canada Inc1998-03-04Not applicableCanada
Effexor XRCapsule, extended release37.5 mg/1OralPhysicians Total Care, Inc.2004-04-07Not applicableUs
Effexor XRCapsule, extended release150 mg/1OralStat Rx USA1997-11-01Not applicableUs
Effexor XRCapsule, extended release37.5 mg/1OralWyeth Pharmaceuticals Inc., a subsidiary of Pfizer Inc.1997-11-01Not applicableUs
Effexor XRCapsule, extended release75 mg/1OralPd Rx Pharmaceuticals, Inc.1997-11-01Not applicableUs
Effexor XRCapsule, extended release75 mgOralPfizer Canada Inc1998-03-04Not applicableCanada
Effexor XRCapsule, extended release150 mg/1Oralbryant ranch prepack1997-11-01Not applicableUs
Effexor XRCapsule, extended release75 mg/1OralREMEDYREPACK INC.2016-05-22Not applicableUs
Effexor XRCapsule, extended release75 mg/1OralLake Erie Medical DBA Quality Care Products LLC2011-01-31Not applicableUs
Effexor XRCapsule, extended release150 mg/1OralPhysicians Total Care, Inc.2001-08-28Not applicableUs
Effexor XRCapsule, extended release150 mgOralPfizer Canada Inc1998-03-04Not applicableCanada
Effexor XRCapsule, extended release75 mg/1OralCardinal Health1997-11-01Not applicableUs
Effexor XR Extended-releaseCapsule, extended release75 mg/1OralRebel Distributors Corp1997-11-01Not applicableUs
Effexor XR Extended-releaseCapsule, extended release150 mg/1OralAphena Pharma Solutions Tennessee, Inc.1997-11-01Not applicableUs
Effexor XR Extended-releaseCapsule, extended release150 mg/1OralRebel Distributors Corp1997-11-01Not applicableUs
Effexor XR Extended-releaseCapsule, extended release37.5 mg/1OralRebel Distributors Corp1997-11-01Not applicableUs
Gd-venlafaxine XRCapsule, extended release37.5 mgOralGenmed A Division Of Pfizer Canada Inc2011-10-28Not applicableCanada
Gd-venlafaxine XRCapsule, extended release75 mgOralGenmed A Division Of Pfizer Canada Inc2011-10-28Not applicableCanada
Gd-venlafaxine XRCapsule, extended release150 mgOralGenmed A Division Of Pfizer Canada Inc2011-10-28Not applicableCanada
Mylan-venlafaxine XRCapsule, extended release75 mgOralMylan Pharmaceuticals Ulc2008-05-07Not applicableCanada
Mylan-venlafaxine XRCapsule, extended release150 mgOralMylan Pharmaceuticals Ulc2008-05-07Not applicableCanada
Mylan-venlafaxine XRCapsule, extended release37.5 mgOralMylan Pharmaceuticals Ulc2008-05-07Not applicableCanada
Ntp-venlafaxine XRCapsule, extended release75 mgOralTeva Canada LimitedNot applicableNot applicableCanada
Ntp-venlafaxine XRCapsule, extended release150 mgOralTeva Canada LimitedNot applicableNot applicableCanada
Ntp-venlafaxine XRCapsule, extended release37.5 mgOralTeva Canada LimitedNot applicableNot applicableCanada
PHL-venlafaxine XRCapsule, extended release37.5 mgOralPharmel IncNot applicableNot applicableCanada
PHL-venlafaxine XRCapsule, extended release75 mgOralPharmel IncNot applicableNot applicableCanada
PHL-venlafaxine XRCapsule, extended release150 mgOralPharmel IncNot applicableNot applicableCanada
PMS-venlafaxine XRCapsule, extended release75 mgOralPharmascience Inc2007-08-17Not applicableCanada
PMS-venlafaxine XRCapsule, extended release150 mgOralPharmascience Inc2007-08-17Not applicableCanada
PMS-venlafaxine XRCapsule, extended release37.5 mgOralPharmascience Inc2007-08-17Not applicableCanada
Ran-venlafaxine XRCapsule, extended release75 mgOralRanbaxy Pharmaceuticals Canada Inc.2012-02-17Not applicableCanada
Ran-venlafaxine XRCapsule, extended release150 mgOralRanbaxy Pharmaceuticals Canada Inc.2012-02-16Not applicableCanada
Ran-venlafaxine XRCapsule, extended release37.5 mgOralRanbaxy Pharmaceuticals Canada Inc.2012-02-17Not applicableCanada
Riva-venlafaxine XRCapsule, extended release37.5 mgOralLaboratoire Riva Inc2008-05-22Not applicableCanada
Riva-venlafaxine XRCapsule, extended release75 mgOralLaboratoire Riva Inc2008-05-22Not applicableCanada
Riva-venlafaxine XRCapsule, extended release150 mgOralLaboratoire Riva Inc2008-05-22Not applicableCanada
Sandoz Venlafaxine XRCapsule, extended release75.0 mgOralSandoz Canada Incorporated2008-05-09Not applicableCanada
Sandoz Venlafaxine XRCapsule, extended release150.0 mgOralSandoz Canada Incorporated2008-05-09Not applicableCanada
Sandoz Venlafaxine XRCapsule, extended release37.5 mgOralSandoz Canada Incorporated2008-05-09Not applicableCanada
Teva-venlafaxine XRCapsule, extended release75 mgOralTeva Canada Limited2006-12-01Not applicableCanada
Teva-venlafaxine XRCapsule, extended release150 mgOralTeva Canada Limited2006-12-01Not applicableCanada
Teva-venlafaxine XRCapsule, extended release37.5 mgOralTeva Canada Limited2006-12-01Not applicableCanada
Venlafaxine HydrochlorideTablet, film coated, extended release37.5 mg/1OralUpstate Pharma, LLC2008-09-30Not applicableUs
Venlafaxine HydrochlorideCapsule, extended release37.5 mg/1OralGreenstone LLC2011-06-02Not applicableUs
Venlafaxine HydrochlorideCapsule, extended release37.5 mg/1OralCarilion Materials Management2011-06-02Not applicableUs
Venlafaxine HydrochlorideTablet, extended release150 mg/1OralTrigen Laboratories, LLC2010-04-29Not applicableUs
Venlafaxine HydrochlorideCapsule, extended release150 mg/1OralRebel Distributors Corp2011-06-10Not applicableUs
Venlafaxine HydrochlorideCapsule, extended release75 mg/1OralApotex Corp.2011-06-102016-11-10Us
Venlafaxine HydrochlorideTablet, extended release75 mg/1OralKremers Urban Pharmaceuticals Inc.2010-04-29Not applicableUs
Venlafaxine HydrochlorideCapsule, extended release150 mg/1OralClinical Solutions Wholesale2011-06-10Not applicableUs
Venlafaxine HydrochlorideCapsule, extended release75 mg/1OralCarilion Materials Management2011-06-02Not applicableUs
Venlafaxine HydrochlorideTablet, extended release150 mg/1OralVertical Pharmaceuticals, LLC2010-04-29Not applicableUs
Venlafaxine HydrochlorideTablet, extended release75 mg/1OralREMEDYREPACK INC.2011-11-172016-11-03Us
Venlafaxine HydrochlorideTablet, film coated, extended release75 mg/1OralUpstate Pharma, LLC2008-10-10Not applicableUs
Venlafaxine HydrochlorideCapsule, extended release75 mg/1OralGreenstone LLC2011-06-02Not applicableUs
Venlafaxine HydrochlorideCapsule, extended release75 mg/1OralUnit Dose Services2011-06-10Not applicableUs
Venlafaxine HydrochlorideTablet, extended release225 mg/1OralTrigen Laboratories, LLC2010-04-29Not applicableUs
Venlafaxine HydrochlorideCapsule, extended release75 mg/1OralLake Erie Medical DBA Quality Care Products LLC2011-06-10Not applicableUs
Venlafaxine HydrochlorideCapsule, extended release150 mg/1OralApotex Corp.2011-06-102016-11-10Us
Venlafaxine HydrochlorideTablet, extended release225 mg/1OralVertical Pharmaceuticals, LLC2010-04-29Not applicableUs
Venlafaxine HydrochlorideCapsule, extended release75 mg/1OralREMEDYREPACK INC.2012-03-14Not applicableUs
Venlafaxine HydrochlorideTablet, extended release150 mg/1OralKremers Urban Pharmaceuticals Inc.2010-04-29Not applicableUs
Venlafaxine HydrochlorideCapsule, delayed release75 mg/1OralDIRECT RX2015-01-01Not applicableUs
Venlafaxine HydrochlorideCapsule, extended release37.5 mg/1OralPreferred Pharmaceuticals, Inc.2014-04-18Not applicableUs
Venlafaxine HydrochlorideTablet, film coated, extended release150 mg/1OralUpstate Pharma, LLC2008-10-10Not applicableUs
Venlafaxine HydrochlorideCapsule, extended release150 mg/1OralGreenstone LLC2011-06-02Not applicableUs
Venlafaxine HydrochlorideCapsule, extended release75 mg/1OralREMEDYREPACK INC.2013-05-08Not applicableUs
Venlafaxine HydrochlorideTablet, extended release37.5 mg/1OralVertical Pharmaceuticals, LLC2010-04-29Not applicableUs
Venlafaxine HydrochlorideCapsule, extended release37.5 mg/1OralMedsource Pharmaceuticals2011-06-10Not applicableUs
Venlafaxine HydrochlorideTablet, extended release37.5 mg/1OralTrigen Laboratories, LLC2010-04-29Not applicableUs
Venlafaxine HydrochlorideTablet, extended release37.5 mg/1OralPhysicians Total Care, Inc.2010-06-11Not applicableUs
Venlafaxine HydrochlorideCapsule, extended release37.5 mg/1OralRebel Distributors Corp2011-06-10Not applicableUs
Venlafaxine HydrochlorideCapsule, extended release150 mg/1OralDIRECT RX2014-01-01Not applicableUs
Venlafaxine HydrochlorideTablet, extended release225 mg/1OralKremers Urban Pharmaceuticals Inc.2010-04-29Not applicableUs
Venlafaxine HydrochlorideTablet, film coated, extended release225 mg/1OralUpstate Pharma, LLC2008-10-17Not applicableUs
Venlafaxine HydrochlorideCapsule, extended release37.5 mg/1OralApotex Corp.2011-06-102016-11-10Us
Venlafaxine HydrochlorideTablet, extended release37.5 mg/1OralKremers Urban Pharmaceuticals Inc.2010-04-29Not applicableUs
Venlafaxine HydrochlorideTablet, extended release225 mg/1OralClinical Solutions Wholesale2010-04-29Not applicableUs
Venlafaxine HydrochlorideTablet, extended release75 mg/1OralVertical Pharmaceuticals, LLC2010-04-29Not applicableUs
Venlafaxine HydrochlorideCapsule, extended release75 mg/1OralMedsource Pharmaceuticals2011-06-10Not applicableUs
Venlafaxine HydrochlorideTablet, extended release75 mg/1OralTrigen Laboratories, LLC2010-04-29Not applicableUs
Venlafaxine HydrochlorideCapsule, extended release75 mg/1OralRebel Distributors Corp2011-06-10Not applicableUs
Venlafaxine Hydrochloride Extended-release CapsulesCapsule, extended release75 mgOralDr Reddys Laboratories IncNot applicableNot applicableCanada
Venlafaxine Hydrochloride Extended-release CapsulesCapsule, extended release150 mgOralDr Reddys Laboratories IncNot applicableNot applicableCanada
Venlafaxine Hydrochloride Extended-release CapsulesCapsule, extended release37.5 mgOralDr Reddys Laboratories IncNot applicableNot applicableCanada
Venlafaxine XRCapsule, extended release75 mgOralSivem Pharmaceuticals Ulc2012-06-10Not applicableCanada
Venlafaxine XRCapsule, extended release37.5 mgOralCobalt Pharmaceuticals CompanyNot applicableNot applicableCanada
Venlafaxine XRCapsule, extended release37.5 mgOralPharmascience Inc2007-08-02Not applicableCanada
Venlafaxine XRCapsule, extended release150 mgOralPro Doc Limitee2010-02-03Not applicableCanada
Venlafaxine XRCapsule, extended release150 mgOralRanbaxy Pharmaceuticals Canada Inc.Not applicableNot applicableCanada
Venlafaxine XRCapsule, extended release150 mgOralSivem Pharmaceuticals Ulc2012-06-10Not applicableCanada
Venlafaxine XRCapsule, extended release75.0 mgOralCobalt Pharmaceuticals CompanyNot applicableNot applicableCanada
Venlafaxine XRCapsule, extended release75 mgOralPharmascience Inc2007-08-02Not applicableCanada
Venlafaxine XRCapsule, extended release37.5 mgOralSanis Health Inc2010-07-27Not applicableCanada
Venlafaxine XRCapsule, extended release37.5 mgOralTeva Canada LimitedNot applicableNot applicableCanada
Venlafaxine XRCapsule, extended release37.5 mgOralRanbaxy Pharmaceuticals Canada Inc.Not applicableNot applicableCanada
Venlafaxine XRCapsule, extended release37.5 mgOralPro Doc Limitee2010-02-03Not applicableCanada
Venlafaxine XRCapsule, extended release150.0 mgOralCobalt Pharmaceuticals CompanyNot applicableNot applicableCanada
Venlafaxine XRCapsule, extended release150 mgOralPharmascience Inc2007-08-02Not applicableCanada
Venlafaxine XRCapsule, extended release75 mgOralSanis Health Inc2010-07-27Not applicableCanada
Venlafaxine XRCapsule, extended release75 mgOralTeva Canada LimitedNot applicableNot applicableCanada
Venlafaxine XRCapsule, extended release37.5 mgOralSivem Pharmaceuticals Ulc2012-06-10Not applicableCanada
Venlafaxine XRCapsule, extended release75 mgOralRanbaxy Pharmaceuticals Canada Inc.Not applicableNot applicableCanada
Venlafaxine XRCapsule, extended release75 mgOralPro Doc Limitee2010-02-03Not applicableCanada
Venlafaxine XRCapsule, extended release150 mgOralTeva Canada LimitedNot applicableNot applicableCanada
Venlafaxine XRCapsule, extended release150 mgOralSanis Health Inc2010-07-27Not applicableCanada
Approved Generic Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Apo-venlafaxine XRCapsule, extended release150.0 mgOralApotex Inc2013-04-16Not applicableCanada
Apo-venlafaxine XRCapsule, extended release37.5 mgOralApotex Inc2013-04-16Not applicableCanada
Apo-venlafaxine XRCapsule, extended release75.0 mgOralApotex Inc2013-04-16Not applicableCanada
EffexorTablet50 mg/1OralDIRECT RX2016-02-02Not applicableUs
VenlafaxineTablet37.5 mg/1OralTrupharma, Llc2016-04-19Not applicableUs
VenlafaxineTablet75 mg/1OralZydus Pharmaceuticals (USA) Inc.2008-06-13Not applicableUs
VenlafaxineTablet75 mg/1OralAlembic Pharmaceuticals Inc.2015-10-01Not applicableUs
VenlafaxineTablet50 mg/1OralKAISER FOUNDATION HOSPITALS2014-09-03Not applicableUs
VenlafaxineTablet37.5 mg/1OralHeritage Pharmaceuticals Inc.2012-11-30Not applicableUs
VenlafaxineTablet100 mg/1OralAmerican Health Packaging2015-02-15Not applicableUs
VenlafaxineTablet75 mg/1OralCitron Pharma LLC2010-04-07Not applicableUs
VenlafaxineTablet75 mg/1OralREMEDYREPACK INC.2013-05-29Not applicableUs
VenlafaxineTablet100 mg/1OralAurobindo Pharma Limited2010-04-07Not applicableUs
VenlafaxineTablet37.5 mg/1OralBlue Point Laboratories2013-11-25Not applicableUs
VenlafaxineTablet75 mg/1OralState of Florida DOH Central Pharmacy2014-01-01Not applicableUs
VenlafaxineTablet37.5 mg/1OralClinical Solutions Wholesale2010-08-04Not applicableUs
VenlafaxineTablet37.5 mg/1OralQualitest Pharmaceuticals2010-08-042016-10-13Us
VenlafaxineTablet100 mg/1OralREMEDYREPACK INC.2015-10-06Not applicableUs
VenlafaxineTablet75 mg/1OralA S Medication Solutions2010-08-04Not applicableUs
VenlafaxineTablet50 mg/1OralQualitest Pharmaceuticals2010-08-042016-10-13Us
VenlafaxineTablet37.5 mg/1OralAmerican Health Packaging2015-02-15Not applicableUs
VenlafaxineTablet25 mg/1OralAurobindo Pharma Limited2010-04-07Not applicableUs
VenlafaxineTablet50 mg/1OralClinical Solutions Wholesale2010-08-04Not applicableUs
VenlafaxineTablet75 mg/1OralNorth Star Rx Llc2010-12-21Not applicableUs
VenlafaxineTablet25 mg/1OralAlembic Pharmaceuticals Inc.2015-10-01Not applicableUs
VenlafaxineTablet37.5 mg/1OralA S Medication Solutions2012-11-30Not applicableUs
VenlafaxineTablet50 mg/1Oralbryant ranch prepack2012-11-30Not applicableUs
VenlafaxineTablet75 mg/1OralSun Pharmaceutical Industries, Inc.2008-06-13Not applicableUs
VenlafaxineTablet37.5 mg/1OralMylan Institutional Inc.2008-07-15Not applicableUs
VenlafaxineTablet25 mg/1OralZydus Pharmaceuticals (USA) Inc.2008-06-13Not applicableUs
VenlafaxineTablet50 mg/1OralTrigen Laboratories, LLC2010-12-21Not applicableUs
VenlafaxineTablet100 mg/1OralNcs Health Care Of Ky, Inc Dba Vangard Labs2008-06-13Not applicableUs
VenlafaxineTablet50 mg/1OralHeritage Pharmaceuticals Inc.2012-11-30Not applicableUs
VenlafaxineTablet50 mg/1OralTrupharma, Llc2016-04-19Not applicableUs
VenlafaxineTablet75 mg/1OralA S Medication Solutions2008-06-13Not applicableUs
VenlafaxineTablet100 mg/1OralREMEDYREPACK INC.2014-02-19Not applicableUs
VenlafaxineTablet100 mg/1OralZydus Pharmaceuticals (USA) Inc.2008-06-13Not applicableUs
VenlafaxineTablet100 mg/1OralAlembic Pharmaceuticals Inc.2015-10-01Not applicableUs
VenlafaxineTablet100 mg/1OralKAISER FOUNDATION HOSPITALS2014-09-03Not applicableUs
VenlafaxineTablet100 mg/1OralCitron Pharma LLC2010-04-07Not applicableUs
VenlafaxineTablet37.5 mg/1OralREMEDYREPACK INC.2013-05-29Not applicableUs
VenlafaxineTablet25 mg/1OralSun Pharmaceutical Industries, Inc.2008-06-13Not applicableUs
VenlafaxineTablet50 mg/1OralBlue Point Laboratories2013-11-25Not applicableUs
VenlafaxineTablet37.5 mg/1OralNcs Health Care Of Ky, Inc Dba Vangard Labs2008-06-13Not applicableUs
VenlafaxineTablet25 mg/1OralNorth Star Rx Llc2010-12-21Not applicableUs
VenlafaxineTablet37.5 mg/1OralREMEDYREPACK INC.2015-10-16Not applicableUs
VenlafaxineTablet75 mg/1OralQualitest Pharmaceuticals2010-08-042016-10-13Us
VenlafaxineTablet75 mg/1OralAmerican Health Packaging2015-02-15Not applicableUs
VenlafaxineTablet37.5 mg/1OralAurobindo Pharma Limited2010-04-07Not applicableUs
VenlafaxineTablet25 mg/1OralCitron Pharma LLC2010-04-07Not applicableUs
VenlafaxineTablet75 mg/1OralA S Medication Solutions2008-06-13Not applicableUs
VenlafaxineTablet37.5 mg/1OralAidarex Pharmaceuticals LLC2012-11-30Not applicableUs
VenlafaxineTablet75 mg/1OralClinical Solutions Wholesale2010-08-04Not applicableUs
VenlafaxineTablet75 mg/1OralDIRECT RX2015-01-01Not applicableUs
VenlafaxineTablet100 mg/1OralNorth Star Rx Llc2010-12-21Not applicableUs
VenlafaxineTablet37.5 mg/1OralAlembic Pharmaceuticals Inc.2015-10-01Not applicableUs
VenlafaxineTablet75 mg/1OralA S Medication Solutions2008-06-13Not applicableUs
VenlafaxineTablet100 mg/1OralProficient Rx LP2015-10-01Not applicableUs
VenlafaxineTablet75 mg/1OralREMEDYREPACK INC.2016-01-25Not applicableUs
VenlafaxineTablet100 mg/1OralSun Pharmaceutical Industries, Inc.2008-06-13Not applicableUs
VenlafaxineTablet75 mg/1OralMylan Institutional Inc.2008-07-15Not applicableUs
VenlafaxineTablet37.5 mg/1OralZydus Pharmaceuticals (USA) Inc.2008-06-13Not applicableUs
VenlafaxineTablet75 mg/1OralTrigen Laboratories, LLC2010-12-21Not applicableUs
VenlafaxineTablet37.5 mg/1OralSt Marys Medical Park Pharmacy2016-04-01Not applicableUs
VenlafaxineTablet75 mg/1OralHeritage Pharmaceuticals Inc.2012-11-30Not applicableUs
VenlafaxineTablet75 mg/1OralTrupharma, Llc2016-04-19Not applicableUs
VenlafaxineTablet37.5 mg/1OralA S Medication Solutions2008-06-13Not applicableUs
VenlafaxineTablet37.5 mg/1OralAidarex Pharmaceuticals LLC2008-06-13Not applicableUs
VenlafaxineTablet50 mg/1OralREMEDYREPACK INC.2015-10-27Not applicableUs
VenlafaxineTablet37.5 mg/1OralSun Pharmaceutical Industries, Inc.2008-06-13Not applicableUs
VenlafaxineTablet75 mg/1OralBlue Point Laboratories2013-11-25Not applicableUs
VenlafaxineTablet25 mg/1OralTrigen Laboratories, LLC2010-12-21Not applicableUs
VenlafaxineTablet75 mg/1OralNcs Health Care Of Ky, Inc Dba Vangard Labs2008-06-13Not applicableUs
VenlafaxineTablet75 mg/1OralPd Rx Pharmaceuticals, Inc.2008-06-13Not applicableUs
VenlafaxineTablet37.5 mg/1OralNorth Star Rx Llc2010-12-21Not applicableUs
VenlafaxineTablet100 mg/1OralClinical Solutions Wholesale2010-08-04Not applicableUs
VenlafaxineTablet75 mg/1OralREMEDYREPACK INC.2015-09-28Not applicableUs
VenlafaxineTablet100 mg/1OralQualitest Pharmaceuticals2010-08-042016-10-13Us
VenlafaxineTablet25 mg/1OralAmerican Health Packaging2015-02-15Not applicableUs
VenlafaxineTablet50 mg/1OralAurobindo Pharma Limited2010-04-07Not applicableUs
VenlafaxineTablet37.5 mg/1OralCitron Pharma LLC2010-04-07Not applicableUs
VenlafaxineTablet25 mg/1OralREMEDYREPACK INC.2013-05-28Not applicableUs
VenlafaxineTablet100 mg/1OralBlue Point Laboratories2013-11-25Not applicableUs
VenlafaxineTablet75 mg/1OralAidarex Pharmaceuticals LLC2012-11-30Not applicableUs
VenlafaxineTablet50 mg/1OralZydus Pharmaceuticals (USA) Inc.2008-06-13Not applicableUs
VenlafaxineTablet100 mg/1OralTrigen Laboratories, LLC2010-12-21Not applicableUs
VenlafaxineTablet37.5 mg/1OralDIRECT RX2015-01-01Not applicableUs
VenlafaxineTablet50 mg/1OralAlembic Pharmaceuticals Inc.2015-10-01Not applicableUs
VenlafaxineTablet25 mg/1OralKAISER FOUNDATION HOSPITALS2014-09-03Not applicableUs
VenlafaxineTablet25 mg/1OralHeritage Pharmaceuticals Inc.2012-11-30Not applicableUs
VenlafaxineTablet25 mg/1OralTrupharma, Llc2016-04-19Not applicableUs
VenlafaxineTablet50 mg/1OralDIRECT RX2014-01-01Not applicableUs
VenlafaxineTablet25 mg/1OralREMEDYREPACK INC.2016-05-25Not applicableUs
VenlafaxineTablet100 mg/1OralHeritage Pharmaceuticals Inc.2012-11-30Not applicableUs
VenlafaxineTablet100 mg/1OralTrupharma, Llc2016-04-19Not applicableUs
VenlafaxineTablet50 mg/1OralAidarex Pharmaceuticals LLC2008-06-13Not applicableUs
VenlafaxineTablet75 mg/1OralProficient Rx LP2008-06-13Not applicableUs
VenlafaxineTablet50 mg/1OralNorth Star Rx Llc2010-12-21Not applicableUs
VenlafaxineTablet75 mg/1OralDIRECT RX2014-01-01Not applicableUs
VenlafaxineTablet50 mg/1OralSun Pharmaceutical Industries, Inc.2008-06-13Not applicableUs
VenlafaxineTablet37.5 mg/1OralTrigen Laboratories, LLC2010-12-21Not applicableUs
VenlafaxineTablet50 mg/1OralNcs Health Care Of Ky, Inc Dba Vangard Labs2008-06-13Not applicableUs
VenlafaxineTablet25 mg/1OralBlue Point Laboratories2013-11-25Not applicableUs
VenlafaxineTablet25 mg/1OralClinical Solutions Wholesale2010-08-04Not applicableUs
VenlafaxineTablet25 mg/1OralREMEDYREPACK INC.2015-09-30Not applicableUs
VenlafaxineTablet25 mg/1OralQualitest Pharmaceuticals2010-08-042016-10-13Us
VenlafaxineTablet50 mg/1OralAmerican Health Packaging2015-02-15Not applicableUs
VenlafaxineTablet75 mg/1OralAurobindo Pharma Limited2010-04-07Not applicableUs
VenlafaxineTablet50 mg/1OralCitron Pharma LLC2010-04-07Not applicableUs
VenlafaxineTablet50 mg/1OralREMEDYREPACK INC.2013-05-29Not applicableUs
Venlafaxine HydrochlorideCapsule, extended release37.5 mg/1OralClinical Solutions Wholesale, Llc2011-06-01Not applicableUs
Venlafaxine HydrochlorideCapsule, extended release75 mg/1OralA S Medication Solutions2011-06-01Not applicableUs
Venlafaxine HydrochlorideTablet75 mg/1OralREMEDYREPACK INC.2013-05-03Not applicableUs
Venlafaxine HydrochlorideTablet37.5 mg/1OralSTAT Rx USA LLC2009-11-27Not applicableUs
Venlafaxine HydrochlorideCapsule, extended release37.5 mg/1OralDr.Reddy's laboratories Ltd.2011-06-01Not applicableUs
Venlafaxine HydrochlorideCapsule, extended release150 mg/1OralWockhardt Limited2011-04-14Not applicableUs
Venlafaxine HydrochlorideCapsule, extended release75 mg/1OralProficient Rx LP2010-07-01Not applicableUs
Venlafaxine HydrochlorideCapsule, extended release150 mg/1OralNcs Health Care Of Ky, Inc Dba Vangard Labs2010-07-01Not applicableUs
Venlafaxine HydrochlorideTablet, extended release75 mg/1OralSun Pharma Global Inc.2010-08-18Not applicableUs
Venlafaxine HydrochlorideCapsule, extended release150 mg/1OralAphena Pharma Solutions Tennessee, Llc2013-06-12Not applicableUs
Venlafaxine HydrochlorideTablet37.5 mg/1OralAv Kare, Inc.2012-05-07Not applicableUs
Venlafaxine HydrochlorideTablet37.5 mg/1OralAv Pak2016-05-31Not applicableUs
Venlafaxine HydrochlorideCapsule, extended release37.5 mg/1OralWockhardt USA LLC.2011-04-14Not applicableUs
Venlafaxine HydrochlorideCapsule, extended release150 mg/1OralA S Medication Solutions2010-07-01Not applicableUs
Venlafaxine HydrochlorideTablet75 mg/1OralAmerican Health Packaging2009-01-132016-06-30Us
Venlafaxine HydrochlorideCapsule, extended release75 mg/1OralOrchid Healthcare (a division of Orchid Chemicals & Pharmaceuticals Ltd.)2012-07-07Not applicableUs
Venlafaxine HydrochlorideTablet50 mg/1OralREMEDYREPACK INC.2011-05-02Not applicableUs
Venlafaxine HydrochlorideCapsule, extended release75 mg/1OralTorrent Pharmaceuticals Limited2011-01-06Not applicableUs
Venlafaxine HydrochlorideCapsule, extended release37.5 mg/1OralCardinal Health2011-06-07Not applicableUs
Venlafaxine HydrochlorideCapsule, extended release75 mg/1OralAidarex Pharmaceuticals LLC2010-07-01Not applicableUs
Venlafaxine HydrochlorideTablet37.5 mg/1OralPd Rx Pharmaceuticals, Inc.2009-11-27Not applicableUs
Venlafaxine HydrochlorideTablet100 mg/1OralMylan Pharmaceuticals Inc.2008-06-14Not applicableUs
Venlafaxine HydrochlorideCapsule, extended release37.5 mg/1OralTeva Pharmaceuticals USA Inc2010-07-01Not applicableUs
Venlafaxine HydrochlorideCapsule, extended release75 mg/1Oralbryant ranch prepack2010-06-28Not applicableUs
Venlafaxine HydrochlorideTablet100 mg/1OralYaopharma Co., Ltd.2016-09-06Not applicableUs
Venlafaxine HydrochlorideTablet75 mg/1OralCadila Healthcare Limited2008-06-13Not applicableUs
Venlafaxine HydrochlorideTablet25 mg/1OralTeva Pharmaceuticals Usa, Inc.2006-08-04Not applicableUs
Venlafaxine HydrochlorideTablet75 mg/1OralRebel Distributors Corp2008-06-13Not applicableUs
Venlafaxine HydrochlorideTablet, extended release37.5 mg/1OralSun Pharma Global FZE2014-12-15Not applicableUs
Venlafaxine HydrochlorideCapsule, extended release75 mg/1OralREMEDYREPACK INC.2015-03-27Not applicableUs
Venlafaxine HydrochlorideTablet100 mg/1OralAmneal Pharmaceuticals of New York, LLC2010-05-11Not applicableUs
Venlafaxine HydrochlorideTablet25 mg/1OralYaopharma Co., Ltd.2016-09-06Not applicableUs
Venlafaxine HydrochlorideCapsule, extended release150 mg/1OralTYA Pharmaceuticals2011-06-01Not applicableUs
Venlafaxine HydrochlorideCapsule, extended release75 mg/1OralREMEDYREPACK INC.2016-08-31Not applicableUs
Venlafaxine HydrochlorideCapsule, extended release150 mg/1OralAmerican Health Packaging2011-06-012015-12-31Us
Venlafaxine HydrochlorideCapsule, extended release75 mg/1OralClinical Solutions Wholesale, Llc2010-07-01Not applicableUs
Venlafaxine HydrochlorideTablet25 mg/1OralMylan Pharmaceuticals Inc.2008-06-14Not applicableUs
Venlafaxine HydrochlorideTablet37.5 mg/1OralDIRECT RX2014-01-01Not applicableUs
Venlafaxine HydrochlorideTablet100 mg/1OralREMEDYREPACK INC.2014-03-24Not applicableUs
Venlafaxine HydrochlorideCapsule, extended release37.5 mg/1OralPreferred Pharmaceuticals Inc.2016-11-22Not applicableUs
Venlafaxine HydrochlorideTablet100 mg/1OralRebel Distributors Corp.2009-09-03Not applicableUs
Venlafaxine HydrochlorideTablet37.5 mg/1OralDr. Reddy's Laboratories Limited2008-06-16Not applicableUs
Venlafaxine HydrochlorideCapsule, extended release150 mg/1OralProficient Rx LP2010-07-01Not applicableUs
Venlafaxine HydrochlorideCapsule, extended release37.5 mg/1OralMajor Pharmaceuticals2015-04-06Not applicableUs
Venlafaxine HydrochlorideCapsule, extended release150 mg/1OralLake Erie Medical DBA Quality Care Products LLC2010-07-01Not applicableUs
Venlafaxine HydrochlorideTablet75 mg/1OralAphena Pharma Solutions Tennessee, Llc2010-08-04Not applicableUs
Venlafaxine HydrochlorideTablet50 mg/1OralKAISER FOUNDATION HOSPITALS2012-01-05Not applicableUs
Venlafaxine HydrochlorideCapsule, extended release150 mg/1OralAidarex Pharmaceuticals LLC2011-06-01Not applicableUs
Venlafaxine HydrochlorideCapsule, extended release150 mg/1OralCadila Healthcare Limited2011-06-01Not applicableUs
Venlafaxine HydrochlorideTablet100 mg/1OralTeva Pharmaceuticals Usa, Inc.2006-08-04Not applicableUs
Venlafaxine HydrochlorideCapsule, extended release150 mg/1OralZydus Pharmaceuticals (USA) Inc.2011-06-01Not applicableUs
Venlafaxine HydrochlorideCapsule, extended release150 mg/1OralAurobindo Pharma Limited2011-11-23Not applicableUs
Venlafaxine HydrochlorideCapsule, extended release150 mg/1OralPhysicians Total Care, Inc.2010-08-02Not applicableUs
Venlafaxine HydrochlorideCapsule, extended release150 mg/1OralCardinal Health2011-06-01Not applicableUs
Venlafaxine HydrochlorideTablet75 mg/1OralSt. Marys Medical Park Pharmacy2011-01-30Not applicableUs
Venlafaxine HydrochlorideCapsule, extended release37.5 mg/1OralAmerican Health Packaging2014-02-03Not applicableUs
Venlafaxine HydrochlorideCapsule, extended release150 mg/1OralOrchid Healthcare (a division of Orchid Chemicals & Pharmaceuticals Ltd.)2012-07-07Not applicableUs
Venlafaxine HydrochlorideCapsule, extended release75 mg/1OralClinical Solutions Wholesale, Llc2011-06-01Not applicableUs
Venlafaxine HydrochlorideTablet25 mg/1OralRebel Distributors Corp.2009-09-03Not applicableUs
Venlafaxine HydrochlorideCapsule, extended release75 mg/1OralDr.Reddy's laboratories Ltd.2011-06-01Not applicableUs
Venlafaxine HydrochlorideTablet75 mg/1OralLake Erie Medical DBA Quality Care Products LLC2010-08-04Not applicableUs
Venlafaxine HydrochlorideCapsule, extended release150 mg/1OralProficient Rx LP2011-06-10Not applicableUs
Venlafaxine HydrochlorideCapsule, extended release37.5 mg/1OralMajor Pharmaceuticals2011-06-07Not applicableUs
Venlafaxine HydrochlorideTablet, extended release37.5 mg/1OralSun Pharma Global Inc.2010-08-18Not applicableUs
Venlafaxine HydrochlorideCapsule, extended release75 mg/1OralAphena Pharma Solutions Tennessee, Llc2013-06-12Not applicableUs
Venlafaxine HydrochlorideTablet50 mg/1OralAv Kare, Inc.2012-05-07Not applicableUs
Venlafaxine HydrochlorideTablet50 mg/1OralAv Pak2016-05-31Not applicableUs
Venlafaxine HydrochlorideCapsule, extended release75 mg/1OralWockhardt USA LLC.2011-04-14Not applicableUs
Venlafaxine HydrochlorideCapsule, extended release150 mg/1OralA S Medication Solutions2010-07-01Not applicableUs
Venlafaxine HydrochlorideCapsule, extended release150 mg/1Oralbryant ranch prepack2010-07-01Not applicableUs
Venlafaxine HydrochlorideCapsule, extended release37.5 mg/1OralLucid Pharma Llc2011-06-01Not applicableUs
Venlafaxine HydrochlorideTablet100 mg/1OralCadila Healthcare Limited2008-06-13Not applicableUs
Venlafaxine HydrochlorideTablet37.5 mg/1OralTeva Pharmaceuticals Usa, Inc.2006-08-04Not applicableUs
Venlafaxine HydrochlorideTablet25 mg/1OralCarilion Materials Management2006-08-04Not applicableUs
Venlafaxine HydrochlorideCapsule, extended release150 mg/1OralREMEDYREPACK INC.2011-08-04Not applicableUs
Venlafaxine HydrochlorideCapsule, extended release150 mg/1OralTorrent Pharmaceuticals Limited2011-01-06Not applicableUs
Venlafaxine HydrochlorideTablet37.5 mg/1OralPhysicians Total Care, Inc.2007-07-19Not applicableUs
Venlafaxine HydrochlorideCapsule, extended release150 mg/1OralCardinal Health2011-06-07Not applicableUs
Venlafaxine HydrochlorideCapsule, extended release37.5 mg/1OralGolden State Medical Supply, Inc2013-06-12Not applicableUs
Venlafaxine HydrochlorideCapsule, extended release75 mg/1OralRx Change Co.2014-11-27Not applicableUs
Venlafaxine HydrochlorideCapsule, extended release37.5 mg/1OralPd Rx Pharmaceuticals, Inc.2011-06-01Not applicableUs
Venlafaxine HydrochlorideTablet75 mg/1OralA S Medication Solutions2010-05-11Not applicableUs
Venlafaxine HydrochlorideCapsule, extended release75 mg/1OralTeva Pharmaceuticals USA Inc2010-07-01Not applicableUs
Venlafaxine HydrochlorideCapsule, extended release37.5 mg/1OralAv Kare, Inc.2013-07-10Not applicableUs
Venlafaxine HydrochlorideTablet75 mg/1OralREMEDYREPACK INC.2013-05-142016-10-13Us
Venlafaxine HydrochlorideCapsule, extended release150 mg/1OralREMEDYREPACK INC.2015-05-30Not applicableUs
Venlafaxine HydrochlorideTablet50 mg/1OralAmneal Pharmaceuticals of New York, LLC2010-05-11Not applicableUs
Venlafaxine HydrochlorideTablet37.5 mg/1OralYaopharma Co., Ltd.2016-09-06Not applicableUs
Venlafaxine HydrochlorideTablet25 mg/1OralCadila Healthcare Limited2008-06-13Not applicableUs
Venlafaxine HydrochlorideCapsule, extended release150 mg/1OralClinical Solutions Wholesale, Llc2010-07-01Not applicableUs
Venlafaxine HydrochlorideTablet37.5 mg/1OralMylan Pharmaceuticals Inc.2008-06-14Not applicableUs
Venlafaxine HydrochlorideTablet50 mg/1OralREMEDYREPACK INC.2014-04-09Not applicableUs
Venlafaxine HydrochlorideTablet50 mg/1OralDr. Reddy's Laboratories Limited2008-06-16Not applicableUs
Venlafaxine HydrochlorideCapsule, extended release37.5 mg/1OralProficient Rx LP2010-07-01Not applicableUs
Venlafaxine HydrochlorideCapsule, extended release75 mg/1OralMajor Pharmaceuticals2015-04-06Not applicableUs
Venlafaxine HydrochlorideCapsule, extended release37.5 mg/1OralNcs Health Care Of Ky, Inc Dba Vangard Labs2010-06-28Not applicableUs
Venlafaxine HydrochlorideCapsule, extended release37.5 mg/1OralLake Erie Medical DBA Quality Care Products LLC2011-06-01Not applicableUs
Venlafaxine HydrochlorideTablet75 mg/1OralAphena Pharma Solutions Tennessee, Llc2012-05-07Not applicableUs
Venlafaxine HydrochlorideCapsule, extended release37.5 mg/1OralA S Medication Solutions2010-07-01Not applicableUs
Venlafaxine HydrochlorideTablet100 mg/1OralKAISER FOUNDATION HOSPITALS2012-01-05Not applicableUs
Venlafaxine HydrochlorideCapsule, extended release150 mg/1OralMc Kesson Packaging Services A Business Unit Of Mc Kesson Corporation2012-10-15Not applicableUs
Venlafaxine HydrochlorideCapsule, extended release75 mg/1OralMed Vantx, Inc.2010-07-01Not applicableUs
Venlafaxine HydrochlorideCapsule, extended release75 mg/1OralPreferred Pharmaceuticals Inc.2015-09-11Not applicableUs
Venlafaxine HydrochlorideCapsule, extended release150 mg/1OralUnit Dose Services2010-07-01Not applicableUs
Venlafaxine HydrochlorideCapsule, extended release37.5 mg/1OralPhysicians Total Care, Inc.2010-11-08Not applicableUs
Venlafaxine HydrochlorideCapsule, extended release37.5 mg/1OralWockhardt Limited2011-04-14Not applicableUs
Venlafaxine HydrochlorideTablet75 mg/1OralAv Pak2016-05-31Not applicableUs
Venlafaxine HydrochlorideCapsule, extended release37.5 mg/1OralKAISER FOUNDATION HOSPITALS2014-10-27Not applicableUs
Venlafaxine HydrochlorideCapsule, extended release150 mg/1OralWockhardt USA LLC.2011-04-14Not applicableUs
Venlafaxine HydrochlorideCapsule, extended release75 mg/1OralAmerican Health Packaging2014-02-03Not applicableUs
Venlafaxine HydrochlorideCapsule, extended release37.5 mg/1OralAmerican Health Packaging2011-06-012015-12-31Us
Venlafaxine HydrochlorideCapsule, extended release150 mg/1OralClinical Solutions Wholesale, Llc2011-11-23Not applicableUs
Venlafaxine HydrochlorideTablet37.5 mg/1OralREMEDYREPACK INC.2014-03-11Not applicableUs
Venlafaxine HydrochlorideTablet37.5 mg/1OralRebel Distributors Corp.2009-09-03Not applicableUs
Venlafaxine HydrochlorideCapsule, extended release150 mg/1OralDr.Reddy's laboratories Ltd.2011-06-01Not applicableUs
Venlafaxine HydrochlorideTablet75 mg/1OralClinical Solutions Wholesale, Llc2006-08-04Not applicableUs
Venlafaxine HydrochlorideCapsule, extended release37.5 mg/1OralProficient Rx LP2011-06-10Not applicableUs
Venlafaxine HydrochlorideCapsule, extended release75 mg/1OralMajor Pharmaceuticals2011-06-07Not applicableUs
Venlafaxine HydrochlorideTablet25 mg/1OralRebel Distributors Corp2008-06-13Not applicableUs
Venlafaxine HydrochlorideTablet, extended release150 mg/1OralSun Pharma Global FZE2014-12-15Not applicableUs
Venlafaxine HydrochlorideTablet75 mg/1OralAv Kare, Inc.2012-05-07Not applicableUs
Venlafaxine HydrochlorideTablet25 mg/1OralAmneal Pharmaceuticals of New York, LLC2010-05-11Not applicableUs
Venlafaxine HydrochlorideCapsule, extended release75 mg/1OralA S Medication Solutions2010-07-01Not applicableUs
Venlafaxine HydrochlorideCapsule, extended release150 mg/1OralTeva Pharmaceuticals USA Inc2010-07-01Not applicableUs
Venlafaxine HydrochlorideTablet100 mg/1Oralbryant ranch prepack2010-05-11Not applicableUs
Venlafaxine HydrochlorideCapsule, extended release75 mg/1OralLucid Pharma Llc2011-06-01Not applicableUs
Venlafaxine HydrochlorideCapsule, extended release37.5 mg/1OralCadila Healthcare Limited2011-06-01Not applicableUs
Venlafaxine HydrochlorideTablet50 mg/1OralTeva Pharmaceuticals Usa, Inc.2006-08-04Not applicableUs
Venlafaxine HydrochlorideCapsule, extended release37.5 mg/1OralZydus Pharmaceuticals (USA) Inc.2011-06-01Not applicableUs
Venlafaxine HydrochlorideCapsule, extended release37.5 mg/1OralAurobindo Pharma Limited2011-06-01Not applicableUs
Venlafaxine HydrochlorideCapsule, extended release75 mg/1OralREMEDYREPACK INC.2011-08-05Not applicableUs
Venlafaxine HydrochlorideTablet75 mg/1OralPhysicians Total Care, Inc.2007-02-02Not applicableUs
Venlafaxine HydrochlorideCapsule, extended release37.5 mg/1OralCardinal Health2011-06-01Not applicableUs
Venlafaxine HydrochlorideCapsule, extended release75 mg/1OralGolden State Medical Supply, Inc2013-06-12Not applicableUs
Venlafaxine HydrochlorideTablet75 mg/1OralLake Erie Medical DBA Quality Care Products LLC2008-06-13Not applicableUs
Venlafaxine HydrochlorideTablet37.5 mg/1Oralbryant ranch prepack2010-05-11Not applicableUs
Venlafaxine HydrochlorideCapsule, extended release150 mg/1OralMajor Pharmaceuticals2015-04-06Not applicableUs
Venlafaxine HydrochlorideCapsule, extended release75 mg/1OralAv Kare, Inc.2013-07-10Not applicableUs
Venlafaxine HydrochlorideTablet37.5 mg/1OralREMEDYREPACK INC.2010-11-23Not applicableUs
Venlafaxine HydrochlorideTablet75 mg/1OralAmneal Pharmaceuticals of New York, LLC2010-05-11Not applicableUs
Venlafaxine HydrochlorideTablet50 mg/1OralYaopharma Co., Ltd.2016-09-06Not applicableUs
Venlafaxine HydrochlorideTablet37.5 mg/1OralCadila Healthcare Limited2008-06-13Not applicableUs
Venlafaxine HydrochlorideCapsule, extended release75 mg/1OralPreferred Pharmaceuticals Inc.2016-06-20Not applicableUs
Venlafaxine HydrochlorideTablet50 mg/1OralMylan Pharmaceuticals Inc.2008-06-14Not applicableUs
Venlafaxine HydrochlorideTablet100 mg/1OralREMEDYREPACK INC.2014-04-15Not applicableUs
Venlafaxine HydrochlorideTablet75 mg/1OralDr. Reddy's Laboratories Limited2008-06-16Not applicableUs
Venlafaxine HydrochlorideTablet100 mg/1OralPhysicians Total Care, Inc.2011-04-22Not applicableUs
Venlafaxine HydrochlorideCapsule, extended release75 mg/1OralWockhardt Limited2011-04-14Not applicableUs
Venlafaxine HydrochlorideCapsule, extended release75 mg/1OralNcs Health Care Of Ky, Inc Dba Vangard Labs2010-07-01Not applicableUs
Venlafaxine HydrochlorideTablet, extended release150 mg/1OralSun Pharma Global Inc.2010-08-18Not applicableUs
Venlafaxine HydrochlorideTablet37.5 mg/1OralAphena Pharma Solutions Tennessee, Llc2012-05-07Not applicableUs
Venlafaxine HydrochlorideTablet25 mg/1OralAv Kare, Inc.2012-05-07Not applicableUs
Venlafaxine HydrochlorideTablet25 mg/1OralAv Pak2016-05-31Not applicableUs
Venlafaxine HydrochlorideCapsule, extended release150 mg/1OralMc Kesson Packaging Services A Business Unit Of Mc Kesson Corporation2014-05-27Not applicableUs
Venlafaxine HydrochlorideCapsule, extended release75 mg/1OralA S Medication Solutions2011-06-01Not applicableUs
Venlafaxine HydrochlorideTablet37.5 mg/1OralAmerican Health Packaging2009-01-132016-06-30Us
Venlafaxine HydrochlorideCapsule, extended release37.5 mg/1OralOrchid Healthcare (a division of Orchid Chemicals & Pharmaceuticals Ltd.)2012-07-07Not applicableUs
Venlafaxine HydrochlorideCapsule, extended release75 mg/1OralAvera Mc Kennan Hospital2015-07-27Not applicableUs
Venlafaxine HydrochlorideTablet25 mg/1OralREMEDYREPACK INC.2013-02-20Not applicableUs
Venlafaxine HydrochlorideTablet100 mg/1OralAv Kare, Inc.2012-05-07Not applicableUs
Venlafaxine HydrochlorideTablet37.5 mg/1OralAmneal Pharmaceuticals of New York, LLC2010-05-11Not applicableUs
Venlafaxine HydrochlorideTablet100 mg/1OralAv Pak2016-05-31Not applicableUs
Venlafaxine HydrochlorideCapsule, extended release75 mg/1OralKAISER FOUNDATION HOSPITALS2014-10-27Not applicableUs
Venlafaxine HydrochlorideCapsule, extended release37.5 mg/1OralTYA Pharmaceuticals2011-06-01Not applicableUs
Venlafaxine HydrochlorideCapsule, extended release150 mg/1OralAmerican Health Packaging2014-02-03Not applicableUs
Venlafaxine HydrochlorideCapsule, extended release75 mg/1OralAmerican Health Packaging2011-06-012015-12-31Us
Venlafaxine HydrochlorideCapsule, extended release37.5 mg/1OralClinical Solutions Wholesale, Llc2010-07-01Not applicableUs
Venlafaxine HydrochlorideCapsule, extended release37.5 mg/1OralA S Medication Solutions2011-06-01Not applicableUs
Venlafaxine HydrochlorideTablet25 mg/1OralREMEDYREPACK INC.2014-03-11Not applicableUs
Venlafaxine HydrochlorideTablet75 mg/1OralRebel Distributors Corp.2009-09-03Not applicableUs
Venlafaxine HydrochlorideTablet25 mg/1OralDr. Reddy's Laboratories Limited2008-06-16Not applicableUs
Venlafaxine HydrochlorideTablet37.5 mg/1OralClinical Solutions Wholesale, Llc2006-08-04Not applicableUs
Venlafaxine HydrochlorideCapsule, extended release150 mg/1OralMajor Pharmaceuticals2011-06-07Not applicableUs
Venlafaxine HydrochlorideTablet100 mg/1OralRebel Distributors Corp2008-06-13Not applicableUs
Venlafaxine HydrochlorideTablet, extended release75 mg/1OralSun Pharma Global FZE2014-12-15Not applicableUs
Venlafaxine HydrochlorideTablet37.5 mg/1OralAphena Pharma Solutions Tennessee, Llc2010-08-04Not applicableUs
Venlafaxine HydrochlorideCapsule, extended release75 mg/1OralA S Medication Solutions2011-04-14Not applicableUs
Venlafaxine HydrochlorideTablet25 mg/1OralKAISER FOUNDATION HOSPITALS2012-01-05Not applicableUs
Venlafaxine HydrochlorideCapsule, extended release37.5 mg/1Oralbryant ranch prepack2010-07-01Not applicableUs
Venlafaxine HydrochlorideCapsule, extended release150 mg/1OralLucid Pharma Llc2011-11-23Not applicableUs
Venlafaxine HydrochlorideCapsule, extended release75 mg/1OralCadila Healthcare Limited2011-06-01Not applicableUs
Venlafaxine HydrochlorideTablet75 mg/1OralTeva Pharmaceuticals Usa, Inc.2006-08-04Not applicableUs
Venlafaxine HydrochlorideCapsule, extended release75 mg/1OralZydus Pharmaceuticals (USA) Inc.2011-06-01Not applicableUs
Venlafaxine HydrochlorideCapsule, extended release75 mg/1OralAurobindo Pharma Limited2011-06-01Not applicableUs
Venlafaxine HydrochlorideTablet, extended release75 mg/1OralREMEDYREPACK INC.2013-04-11Not applicableUs
Venlafaxine HydrochlorideCapsule, extended release150 mg/1OralPreferred Pharmaceuticals Inc.2016-11-07Not applicableUs
Venlafaxine HydrochlorideCapsule, extended release75 mg/1OralPhysicians Total Care, Inc.2010-11-08Not applicableUs
Venlafaxine HydrochlorideCapsule, extended release75 mg/1OralCardinal Health2011-06-01Not applicableUs
Venlafaxine HydrochlorideCapsule, extended release150 mg/1OralGolden State Medical Supply, Inc2013-06-12Not applicableUs
Venlafaxine HydrochlorideTablet, extended release75 mg/1OralLake Erie Medical & Surgical Supply DBA Quality Care Products LLC2011-12-06Not applicableUs
Venlafaxine HydrochlorideTablet75 mg/1OralH.J. Harkins Company, Inc.2008-06-13Not applicableUs
Venlafaxine HydrochlorideCapsule, extended release150 mg/1OralAidarex Pharmaceuticals LLC2010-07-01Not applicableUs
Venlafaxine HydrochlorideTablet100 mg/1OralDr. Reddy's Laboratories Limited2008-06-16Not applicableUs
Venlafaxine HydrochlorideTablet75 mg/1Oralbryant ranch prepack2008-06-13Not applicableUs
Venlafaxine HydrochlorideCapsule, extended release37.5 mg/1OralTorrent Pharmaceuticals Limited2011-01-06Not applicableUs
Venlafaxine HydrochlorideCapsule, extended release150 mg/1OralAv Kare, Inc.2013-07-10Not applicableUs
Venlafaxine HydrochlorideTablet25 mg/1OralREMEDYREPACK INC.2011-04-25Not applicableUs
Venlafaxine HydrochlorideCapsule, extended release37.5 mg/1OralREMEDYREPACK INC.2016-01-11Not applicableUs
Venlafaxine HydrochlorideTablet75 mg/1OralYaopharma Co., Ltd.2016-09-06Not applicableUs
Venlafaxine HydrochlorideTablet50 mg/1OralCadila Healthcare Limited2008-06-13Not applicableUs
Venlafaxine HydrochlorideCapsule, coated, extended release75 mg/1OralDIRECT RX2014-01-01Not applicableUs
Venlafaxine HydrochlorideTablet75 mg/1OralMylan Pharmaceuticals Inc.2008-06-14Not applicableUs
Approved Over the Counter ProductsNot Available
Unapproved/Other Products Not Available
International Brands
NameCompany
EffexorNot Available
ElafaxNot Available
Brand mixturesNot Available
Salts
Name/CASStructureProperties
Venlafaxine Hydrochloride
Thumb
  • InChI Key: QYRYFNHXARDNFZ-UHFFFAOYNA-N
  • Monoisotopic Mass: 313.180856852
  • Average Mass: 313.863
DBSALT000186
Categories
UNIIGRZ5RCB1QG
CAS number93413-69-5
WeightAverage: 277.4018
Monoisotopic: 277.204179113
Chemical FormulaC17H27NO2
InChI KeyPNVNVHUZROJLTJ-UHFFFAOYSA-N
InChI
InChI=1S/C17H27NO2/c1-18(2)13-16(17(19)11-5-4-6-12-17)14-7-9-15(20-3)10-8-14/h7-10,16,19H,4-6,11-13H2,1-3H3
IUPAC Name
1-[2-(dimethylamino)-1-(4-methoxyphenyl)ethyl]cyclohexan-1-ol
SMILES
COC1=CC=C(C=C1)C(CN(C)C)C1(O)CCCCC1
Pharmacology
IndicationFor the management of major depressive disorder (MDD), generalized anxiety disorder (GAD), social anxiety disorder (social phobia), panic disorder with or without agoraphobia, vasomotor symptoms in women with breast cancer and in postmenopausal women, and neuropathic pain.
Structured Indications
PharmacodynamicsVenlafaxine potentiates the neurotransmitter activity in the central nervous system. Furthermore, venlafaxine and its metabolite, O-desmethylvenlafaxine (ODV) potently inhibit the reuptake of serotonin and norepinephrine and weakly inhibit dopamine reuptake. Both molecules do not bind to muscarinic, histaminergic, or alpha-1 adrenergic receptors. Pharmacologic activity at these receptors is hypothesized to be associated with the various anticholinergic, sedative, and cardiovascular effects seen with other psychotropic drugs. Both also do not have any monoamine oxidase (MAO) inhibitory activity.
Mechanism of actionThe exact mechanism of action of venlafaxine is unknown, but appears to be associated with the its potentiation of neurotransmitter activity in the CNS. Venlafaxine and its active metabolite, O-desmethylvenlafaxine (ODV), inhibit the reuptake of both serotonin and norepinephrine with a potency greater for the 5-HT than for the NE reuptake process. Both venlafaxine and the ODV metabolite have weak inhibitory effects on the reuptake of dopamine but, unlike the tricyclics and similar to SSRIs, they are not active at histaminergic, muscarinic, or alpha(1)-adrenergic receptors.
TargetKindPharmacological actionActionsOrganismUniProt ID
Sodium-dependent serotonin transporterProteinyes
inhibitor
HumanP31645 details
Sodium-dependent noradrenaline transporterProteinyes
inhibitor
HumanP23975 details
Sodium-dependent dopamine transporterProteinunknown
inhibitor
HumanQ01959 details
Related Articles
AbsorptionVenlafaxine is well absorbed. Food does not effect the absorption of venlafaxine or its subsequent metabolism into ODV. Bioavailability is 45% following oral administration. Time to steady state = 3 days.
Volume of distribution
  • 7.5 ± 3.7 L/kg [venlafaxine]
  • 5.7 ± 1.8 L/kg [O-desmethylvenlafaxine(active metabolite)]
Protein bindingThe degree of binding of venlafaxine to human plasma is 27% ± 2% at concentrations ranging from 2.5 to 2215 ng/mL. The degree of ODV binding to human plasma is 30% ± 12% at concentrations ranging from 100 to 500 ng/mL. Protein-binding-induced drug interactions with venlafaxine are not expected.
Metabolism

Undergoes extensive first pass metabolism in the liver to its major, active metabolite, ODV, and two minor, less active metabolites, N-desmethylvenlafaxine and N,O-didesmethylvenlafaxine. Formation of ODV is catalyzed by cytochrome P450 (CYP) 2D6, whereas N-demethylation is catalyzed by CYP3A4, 2C19 and 2C9. ODV possesses antidepressant activity that is comparable to that of venlfaxine.

SubstrateEnzymesProduct
Venlafaxine
O-DesmethylvenlafaxineDetails
Venlafaxine
N-DesmethylvenlafaxineDetails
O-Desmethylvenlafaxine
N,O-DidesmethylvenlafaxineDetails
N,O-Didesmethylvenlafaxine
Not Available
N,O-didesmethylvenlafaxine glucuronideDetails
N,O-Didesmethylvenlafaxine
Not Available
N,N,O-TridesmethylvenlafaxineDetails
O-Desmethylvenlafaxine
Not Available
O-Desmethylvenlafaxine glucuronideDetails
N-Desmethylvenlafaxine
N,O-DidesmethylvenlafaxineDetails
Route of eliminationRenal elimination of venlafaxine and its metabolites is the primary route of excretion. Approximately 87% of a venlafaxine dose is recovered in the urine within 48 hours as either unchanged venlafaxine (5%), unconjugated ODV (29%), conjugated ODV (26%), or other minor inactive metabolites (27%).
Half life5 hours
Clearance

Steady state plasma clearance, venlafaxine = 1.3 ± 0.6 L/h/kg;
Steady state plasma clearance, ODV = 0.4 ± 0.2 L/h/kg.

ToxicityMost patients overdosing with venlafaxine develop only mild symptoms. However, severe toxicity is reported with the most common symptoms being CNS depression, serotonin toxicity, seizure, or cardiac conduction abnormalities. Venlafaxine's toxicity appears to be higher than other SSRIs, with a fatal toxic dose closer to that of the tricyclic antidepressants than the SSRIs. Doses of 900 mg or more are likely to cause moderate toxicity. Deaths have been reported following large doses.
Affected organisms
  • Humans and other mammals
Pathways
PathwayCategorySMPDB ID
Venlafaxine Metabolism PathwayDrug metabolismSMP00636
SNP Mediated Effects
Interacting Gene/EnzymeSNP RS IDAllele nameDefining changeEffectReference(s)
Cytochrome P450 2D6
Gene symbol: CYP2D6
UniProt: P10635
Not AvailableCYP2D6*4A AllelePoor drug metabolizer, lower dose requirements, nausea, vomiting and diarrhea16958828
Cytochrome P450 2D6
Gene symbol: CYP2D6
UniProt: P10635
rs5030655 CYP2D6*6T deletionPoor drug metabolizer, lower dose requirements, nausea, vomiting and diarrhea16958828
Cytochrome P450 2D6
Gene symbol: CYP2D6
UniProt: P10635
rs5030655 CYP2D6*6T deletion, homozygotePoor drug metabolizer, lower dose requirements, nausea, vomiting and diarrhea16958828
Cytochrome P450 2D6
Gene symbol: CYP2D6
UniProt: P10635
Not AvailableCYP2D6*5DeletionPoor drug metabolizer, lower dose requirements, nausea, vomiting and diarrhea16958828
Cytochrome P450 2D6
Gene symbol: CYP2D6
UniProt: P10635
rs3892097 CYP2D6*4A AllelePoor drug metabolizer, lower dose requirements, nausea, vomiting and diarrhea16958828
Multidrug resistance protein 1
Gene symbol: ABCB1
UniProt: P08183
rs2032583 Not AvailableC AlleleImproved response to antidepressant medication17913323
Multidrug resistance protein 1
Gene symbol: ABCB1
UniProt: P08183
rs2032583 Not AvailableA > GIncrease risk of adverse effects22641028
SNP Mediated Adverse Drug Reactions
Interacting Gene/EnzymeSNP RS IDAllele nameDefining changeAdverse ReactionReference(s)
Cytochrome P450 2D6
Gene symbol: CYP2D6
UniProt: P10635
rs5030655 CYP2D6*4del T alleleNausea, vomiting diarrhea16958828
Cytochrome P450 2D6
Gene symbol: CYP2D6
UniProt: P10635
rs3892097 CYP2D6*6A alleleNausea, vomiting diarrhea16958828
Interactions
Drug Interactions
DrugInteractionDrug group
1,1,1,2 TetrafluoroethaneThe risk or severity of adverse effects can be increased when 1,1,1,2 Tetrafluoroethane is combined with Venlafaxine.Investigational
4-MethoxyamphetamineThe metabolism of 4-Methoxyamphetamine can be decreased when combined with Venlafaxine.Experimental, Illicit
7-NitroindazoleThe risk or severity of adverse effects can be increased when 7-Nitroindazole is combined with Venlafaxine.Experimental
7,8-DICHLORO-1,2,3,4-TETRAHYDROISOQUINOLINE7,8-DICHLORO-1,2,3,4-TETRAHYDROISOQUINOLINE may increase the serotonergic activities of Venlafaxine.Experimental
AbirateroneThe serum concentration of Venlafaxine can be increased when it is combined with Abiraterone.Approved
AcarboseVenlafaxine may increase the hypoglycemic activities of Acarbose.Approved, Investigational
AcebutololThe serum concentration of Acebutolol can be increased when it is combined with Venlafaxine.Approved
AcenocoumarolThe risk or severity of adverse effects can be increased when Venlafaxine is combined with Acenocoumarol.Approved
AcepromazineThe risk or severity of adverse effects can be increased when Venlafaxine is combined with Acepromazine.Approved, Vet Approved
AceprometazineThe risk or severity of adverse effects can be increased when Venlafaxine is combined with Aceprometazine.Approved
AcetaminophenThe metabolism of Acetaminophen can be decreased when combined with Venlafaxine.Approved
AcetophenazineThe risk or severity of adverse effects can be increased when Venlafaxine is combined with Acetophenazine.Approved
AcetylcholineThe metabolism of Acetylcholine can be decreased when combined with Venlafaxine.Approved
Acetylsalicylic acidVenlafaxine may increase the antiplatelet activities of Acetylsalicylic acid.Approved, Vet Approved
AdinazolamThe metabolism of Adinazolam can be decreased when combined with Venlafaxine.Approved
adipiplonThe risk or severity of adverse effects can be increased when adipiplon is combined with Venlafaxine.Investigational
AdrafinilVenlafaxine may increase the tachycardic activities of Adrafinil.Withdrawn
AfatinibThe serum concentration of Afatinib can be increased when it is combined with Venlafaxine.Approved
AgmatineVenlafaxine may decrease the antihypertensive activities of Agmatine.Experimental, Investigational
AgomelatineThe risk or severity of adverse effects can be increased when Agomelatine is combined with Venlafaxine.Approved, Investigational
AjmalineThe metabolism of Ajmaline can be decreased when combined with Venlafaxine.Approved
AlbendazoleThe metabolism of Albendazole can be decreased when combined with Venlafaxine.Approved, Vet Approved
AlbiglutideVenlafaxine may increase the hypoglycemic activities of Albiglutide.Approved
AlclometasoneThe metabolism of Alclometasone can be decreased when combined with Venlafaxine.Approved
AldosteroneThe serum concentration of Venlafaxine can be decreased when it is combined with Aldosterone.Experimental
AlectinibThe serum concentration of Venlafaxine can be increased when it is combined with Alectinib.Approved
AlfaxaloneThe risk or severity of adverse effects can be increased when Alfaxalone is combined with Venlafaxine.Vet Approved
AlfentanilThe metabolism of Alfentanil can be decreased when combined with Venlafaxine.Approved, Illicit
AlfuzosinThe metabolism of Alfuzosin can be decreased when combined with Venlafaxine.Approved, Investigational
AliskirenThe metabolism of Aliskiren can be decreased when combined with Venlafaxine.Approved, Investigational
AlitretinoinThe serum concentration of Alitretinoin can be increased when it is combined with Venlafaxine.Approved, Investigational
AllylestrenolThe metabolism of Allylestrenol can be decreased when combined with Venlafaxine.Approved
AlmotriptanThe risk or severity of adverse effects can be increased when Venlafaxine is combined with Almotriptan.Approved, Investigational
AlogliptinThe metabolism of Alogliptin can be decreased when combined with Venlafaxine.Approved
AlosetronThe metabolism of Alosetron can be decreased when combined with Venlafaxine.Approved, Withdrawn
AlphacetylmethadolAlphacetylmethadol may increase the serotonergic activities of Venlafaxine.Experimental, Illicit
AlprazolamThe metabolism of Alprazolam can be decreased when combined with Venlafaxine.Approved, Illicit, Investigational
AlprenololThe metabolism of Alprenolol can be decreased when combined with Venlafaxine.Approved, Withdrawn
AmantadineThe serum concentration of Venlafaxine can be increased when it is combined with Amantadine.Approved
AmbrisentanThe metabolism of Ambrisentan can be decreased when combined with Venlafaxine.Approved, Investigational
AmbroxolThe metabolism of Ambroxol can be decreased when combined with Venlafaxine.Approved
Aminohippuric acidThe serum concentration of Venlafaxine can be increased when it is combined with Aminohippuric acid.Approved
AminophenazoneThe metabolism of Aminophenazone can be decreased when combined with Venlafaxine.Approved, Withdrawn
AminophyllineThe metabolism of Aminophylline can be decreased when combined with Venlafaxine.Approved
AmiodaroneThe metabolism of Venlafaxine can be decreased when combined with Amiodarone.Approved, Investigational
AmisulprideThe risk or severity of adverse effects can be increased when Venlafaxine is combined with Amisulpride.Approved, Investigational
AmitrazVenlafaxine may increase the tachycardic activities of Amitraz.Vet Approved
AmitriptylineThe risk or severity of adverse effects can be increased when Venlafaxine is combined with Amitriptyline.Approved
AmlodipineThe metabolism of Amlodipine can be decreased when combined with Venlafaxine.Approved
AmobarbitalThe risk or severity of adverse effects can be increased when Amobarbital is combined with Venlafaxine.Approved, Illicit
AmoxapineThe risk or severity of adverse effects can be increased when Venlafaxine is combined with Amoxapine.Approved
AmperozideThe risk or severity of adverse effects can be increased when Venlafaxine is combined with Amperozide.Experimental
AmphetamineThe metabolism of Amphetamine can be decreased when combined with Venlafaxine.Approved, Illicit
AmprenavirThe metabolism of Amprenavir can be decreased when combined with Venlafaxine.Approved
AmsacrineThe serum concentration of Venlafaxine can be increased when it is combined with Amsacrine.Approved
AnagrelideVenlafaxine may increase the QTc-prolonging activities of Anagrelide.Approved
AnisodamineVenlafaxine may increase the tachycardic activities of Anisodamine.Investigational
AntipyrineThe metabolism of Antipyrine can be decreased when combined with Venlafaxine.Approved
Aop200704The serum concentration of Aop200704 can be increased when it is combined with Venlafaxine.Investigational
ApixabanThe serum concentration of Apixaban can be increased when it is combined with Venlafaxine.Approved
ApomorphineVenlafaxine may decrease the antihypertensive activities of Apomorphine.Approved, Investigational
ApraclonidineVenlafaxine may increase the tachycardic activities of Apraclonidine.Approved
ApremilastThe metabolism of Apremilast can be decreased when combined with Venlafaxine.Approved, Investigational
AprepitantThe serum concentration of Venlafaxine can be increased when it is combined with Aprepitant.Approved, Investigational
AprindineThe metabolism of Aprindine can be decreased when combined with Venlafaxine.Approved
ArbutamineVenlafaxine may increase the tachycardic activities of Arbutamine.Approved
ArformoterolVenlafaxine may increase the tachycardic activities of Arformoterol.Approved, Investigational
ArgatrobanThe metabolism of Argatroban can be decreased when combined with Venlafaxine.Approved, Investigational
AripiprazoleThe serum concentration of Aripiprazole can be increased when it is combined with Venlafaxine.Approved, Investigational
ArmodafinilThe metabolism of Venlafaxine can be decreased when combined with Armodafinil.Approved, Investigational
ArotinololThe serum concentration of Arotinolol can be increased when it is combined with Venlafaxine.Approved
Arsenic trioxideVenlafaxine may increase the QTc-prolonging activities of Arsenic trioxide.Approved, Investigational
ArtemetherVenlafaxine may increase the QTc-prolonging activities of Artemether.Approved
ArticaineThe risk or severity of adverse effects can be increased when Articaine is combined with Venlafaxine.Approved
AsenapineVenlafaxine may increase the QTc-prolonging activities of Asenapine.Approved
AstemizoleThe metabolism of Astemizole can be decreased when combined with Venlafaxine.Approved, Withdrawn
AtazanavirThe metabolism of Venlafaxine can be decreased when combined with Atazanavir.Approved, Investigational
AtenololThe serum concentration of Venlafaxine can be increased when it is combined with Atenolol.Approved
AtomoxetineThe metabolism of Venlafaxine can be decreased when combined with Atomoxetine.Approved
AtorvastatinThe metabolism of Atorvastatin can be decreased when combined with Venlafaxine.Approved
AvanafilThe serum concentration of Avanafil can be increased when it is combined with Venlafaxine.Approved
AxitinibThe metabolism of Axitinib can be decreased when combined with Venlafaxine.Approved, Investigational
AzaperoneThe risk or severity of adverse effects can be increased when Venlafaxine is combined with Azaperone.Vet Approved
AzelastineThe metabolism of Azelastine can be decreased when combined with Venlafaxine.Approved
AzithromycinVenlafaxine may increase the QTc-prolonging activities of Azithromycin.Approved
BaclofenThe risk or severity of adverse effects can be increased when Baclofen is combined with Venlafaxine.Approved
BanoxantroneThe metabolism of Banoxantrone can be decreased when combined with Venlafaxine.Investigational
BarbitalThe risk or severity of adverse effects can be increased when Barbital is combined with Venlafaxine.Illicit
BedaquilineVenlafaxine may increase the QTc-prolonging activities of Bedaquiline.Approved
BefunololVenlafaxine may increase the tachycardic activities of Befunolol.Experimental
BendroflumethiazideVenlafaxine may increase the hyponatremic activities of Bendroflumethiazide.Approved
BenmoxinBenmoxin may increase the serotonergic activities of Venlafaxine.Withdrawn
BenperidolThe risk or severity of adverse effects can be increased when Venlafaxine is combined with Benperidol.Investigational
BenzatropineThe metabolism of Benzatropine can be decreased when combined with Venlafaxine.Approved
BenzocaineThe serum concentration of Venlafaxine can be increased when it is combined with Benzocaine.Approved
BenzphetamineThe metabolism of Benzphetamine can be decreased when combined with Venlafaxine.Approved, Illicit
Benzyl alcoholThe metabolism of Benzyl alcohol can be decreased when combined with Venlafaxine.Approved
BepridilThe serum concentration of Venlafaxine can be increased when it is combined with Bepridil.Approved, Withdrawn
BetamethasoneThe serum concentration of Betamethasone can be increased when it is combined with Venlafaxine.Approved, Vet Approved
BetaxololThe metabolism of Betaxolol can be decreased when combined with Venlafaxine.Approved
BethanidineVenlafaxine may decrease the antihypertensive activities of Bethanidine.Approved
BevantololThe serum concentration of Bevantolol can be increased when it is combined with Venlafaxine.Approved
BexaroteneThe serum concentration of Venlafaxine can be decreased when it is combined with Bexarotene.Approved, Investigational
BezafibrateThe metabolism of Bezafibrate can be decreased when combined with Venlafaxine.Approved
BezitramideBezitramide may increase the serotonergic activities of Venlafaxine.Experimental, Illicit, Withdrawn
BicalutamideThe metabolism of Bicalutamide can be decreased when combined with Venlafaxine.Approved
BifeprunoxThe risk or severity of adverse effects can be increased when Venlafaxine is combined with Bifeprunox.Investigational
BiperidenThe serum concentration of Venlafaxine can be increased when it is combined with Biperiden.Approved
BisoprololThe metabolism of Bisoprolol can be decreased when combined with Venlafaxine.Approved
BitolterolVenlafaxine may increase the tachycardic activities of Bitolterol.Withdrawn
BoceprevirThe metabolism of Venlafaxine can be decreased when combined with Boceprevir.Approved
BopindololThe serum concentration of Bopindolol can be increased when it is combined with Venlafaxine.Approved
BortezomibThe metabolism of Venlafaxine can be decreased when combined with Bortezomib.Approved, Investigational
BosentanThe serum concentration of Bosentan can be increased when it is combined with Venlafaxine.Approved, Investigational
BosutinibThe serum concentration of Bosutinib can be increased when it is combined with Venlafaxine.Approved
Brentuximab vedotinThe serum concentration of Brentuximab vedotin can be increased when it is combined with Venlafaxine.Approved
BrexpiprazoleThe serum concentration of Brexpiprazole can be increased when it is combined with Venlafaxine.Approved
BrimonidineVenlafaxine may increase the tachycardic activities of Brimonidine.Approved
BrinzolamideThe metabolism of Brinzolamide can be decreased when combined with Venlafaxine.Approved
BromazepamThe metabolism of Bromazepam can be decreased when combined with Venlafaxine.Approved, Illicit
BromocriptineThe risk or severity of adverse effects can be increased when Venlafaxine is combined with Bromocriptine.Approved, Investigational
BromperidolThe risk or severity of adverse effects can be increased when Venlafaxine is combined with Bromperidol.Investigational
BrompheniramineThe metabolism of Brompheniramine can be decreased when combined with Venlafaxine.Approved
BrotizolamThe risk or severity of adverse effects can be increased when Brotizolam is combined with Venlafaxine.Approved, Withdrawn
BucindololThe serum concentration of Bucindolol can be increased when it is combined with Venlafaxine.Investigational
BudesonideThe serum concentration of Budesonide can be increased when it is combined with Venlafaxine.Approved
BudesonideThe metabolism of Budesonide can be decreased when combined with Venlafaxine.Approved
BufuralolThe metabolism of Bufuralol can be decreased when combined with Venlafaxine.Experimental, Investigational
BupivacaineThe metabolism of Bupivacaine can be decreased when combined with Venlafaxine.Approved, Investigational
BupranololThe serum concentration of Bupranolol can be increased when it is combined with Venlafaxine.Approved
BuprenorphineThe metabolism of Buprenorphine can be decreased when combined with Venlafaxine.Approved, Illicit, Investigational, Vet Approved
BupropionThe serum concentration of Bupropion can be increased when it is combined with Venlafaxine.Approved
BuspironeBuspirone may increase the serotonergic activities of Venlafaxine.Approved, Investigational
BusulfanThe metabolism of Busulfan can be decreased when combined with Venlafaxine.Approved, Investigational
ButabarbitalThe risk or severity of adverse effects can be increased when Butabarbital is combined with Venlafaxine.Approved, Illicit
ButacaineThe risk or severity of adverse effects can be increased when Butacaine is combined with Venlafaxine.Vet Approved
ButalbitalThe risk or severity of adverse effects can be increased when Butalbital is combined with Venlafaxine.Approved, Illicit
ButambenThe risk or severity of adverse effects can be increased when Butamben is combined with Venlafaxine.Approved
ButethalThe risk or severity of adverse effects can be increased when Butethal is combined with Venlafaxine.Approved, Illicit
ButorphanolButorphanol may increase the serotonergic activities of Venlafaxine.Approved, Illicit, Vet Approved
CabazitaxelThe metabolism of Cabazitaxel can be decreased when combined with Venlafaxine.Approved
CabergolineThe risk or severity of adverse effects can be increased when Cabergoline is combined with Venlafaxine.Approved
CabozantinibThe metabolism of Cabozantinib can be decreased when combined with Venlafaxine.Approved
CaffeineThe metabolism of Caffeine can be decreased when combined with Venlafaxine.Approved
CalcitriolThe metabolism of Calcitriol can be decreased when combined with Venlafaxine.Approved, Nutraceutical
CamptothecinThe serum concentration of Camptothecin can be increased when it is combined with Venlafaxine.Experimental
CanagliflozinThe metabolism of Canagliflozin can be decreased when combined with Venlafaxine.Approved
CandesartanThe serum concentration of Venlafaxine can be increased when it is combined with Candesartan.Approved
CapecitabineThe metabolism of Venlafaxine can be decreased when combined with Capecitabine.Approved, Investigational
CaptoprilThe serum concentration of Venlafaxine can be increased when it is combined with Captopril.Approved
CarbamazepineThe metabolism of Carbamazepine can be decreased when combined with Venlafaxine.Approved, Investigational
CarbinoxamineThe metabolism of Carbinoxamine can be decreased when combined with Venlafaxine.Approved
CarfentanilCarfentanil may increase the serotonergic activities of Venlafaxine.Illicit, Vet Approved
CarfilzomibThe serum concentration of Carfilzomib can be increased when it is combined with Venlafaxine.Approved
CariprazineThe metabolism of Cariprazine can be decreased when combined with Venlafaxine.Approved
CarisoprodolThe risk or severity of adverse effects can be increased when Carisoprodol is combined with Venlafaxine.Approved
CaroxazoneCaroxazone may increase the serotonergic activities of Venlafaxine.Withdrawn
CarteololThe metabolism of Carteolol can be decreased when combined with Venlafaxine.Approved
CarvedilolThe metabolism of Carvedilol can be decreased when combined with Venlafaxine.Approved, Investigational
CaspofunginThe serum concentration of Venlafaxine can be increased when it is combined with Caspofungin.Approved
CelecoxibVenlafaxine may increase the antiplatelet activities of Celecoxib.Approved, Investigational
CeliprololThe metabolism of Celiprolol can be decreased when combined with Venlafaxine.Approved, Investigational
CephalexinThe metabolism of Cephalexin can be decreased when combined with Venlafaxine.Approved, Vet Approved
CeritinibThe serum concentration of Venlafaxine can be increased when it is combined with Ceritinib.Approved
CerivastatinThe metabolism of Cerivastatin can be decreased when combined with Venlafaxine.Withdrawn
CetirizineThe risk or severity of adverse effects can be increased when Cetirizine is combined with Venlafaxine.Approved
CevimelineThe metabolism of Cevimeline can be decreased when combined with Venlafaxine.Approved
Chenodeoxycholic acidThe metabolism of Chenodeoxycholic acid can be decreased when combined with Venlafaxine.Approved
Chloral hydrateThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Venlafaxine.Approved, Illicit, Vet Approved
ChloramphenicolThe metabolism of Venlafaxine can be decreased when combined with Chloramphenicol.Approved, Vet Approved
ChlordiazepoxideThe metabolism of Chlordiazepoxide can be decreased when combined with Venlafaxine.Approved, Illicit
ChlormezanoneThe risk or severity of adverse effects can be increased when Chlormezanone is combined with Venlafaxine.Approved, Withdrawn
ChloroprocaineThe risk or severity of adverse effects can be increased when Chloroprocaine is combined with Venlafaxine.Approved
ChloroquineVenlafaxine may increase the QTc-prolonging activities of Chloroquine.Approved, Vet Approved
ChlorothiazideVenlafaxine may increase the hyponatremic activities of Chlorothiazide.Approved, Vet Approved
ChlorphenamineThe metabolism of Chlorphenamine can be decreased when combined with Venlafaxine.Approved
ChlorpromazineVenlafaxine may increase the QTc-prolonging activities of Chlorpromazine.Approved, Vet Approved
ChlorpropamideThe serum concentration of Venlafaxine can be increased when it is combined with Chlorpropamide.Approved
ChlorprothixeneThe serum concentration of Venlafaxine can be increased when it is combined with Chlorprothixene.Approved, Withdrawn
ChlorthalidoneVenlafaxine may increase the hyponatremic activities of Chlorthalidone.Approved
ChlorzoxazoneThe metabolism of Chlorzoxazone can be decreased when combined with Venlafaxine.Approved
CholecalciferolThe metabolism of Cholecalciferol can be decreased when combined with Venlafaxine.Approved, Nutraceutical
CholesterolThe serum concentration of Venlafaxine can be increased when it is combined with Cholesterol.Experimental
Cholic AcidThe serum concentration of Venlafaxine can be decreased when it is combined with Cholic Acid.Approved
CiclesonideThe metabolism of Ciclesonide can be decreased when combined with Venlafaxine.Approved, Investigational
CilazaprilThe serum concentration of Venlafaxine can be increased when it is combined with Cilazapril.Approved
CilostazolThe serum concentration of Cilostazol can be increased when it is combined with Venlafaxine.Approved
CimetidineThe metabolism of Venlafaxine can be decreased when combined with Cimetidine.Approved
CinacalcetThe metabolism of Venlafaxine can be decreased when combined with Cinacalcet.Approved
CinchocaineThe risk or severity of adverse effects can be increased when Cinchocaine is combined with Venlafaxine.Approved, Vet Approved
CinnarizineThe metabolism of Cinnarizine can be decreased when combined with Venlafaxine.Approved
CiprofloxacinVenlafaxine may increase the QTc-prolonging activities of Ciprofloxacin.Approved, Investigational
CirazolineVenlafaxine may increase the tachycardic activities of Cirazoline.Experimental
CisaprideVenlafaxine may increase the QTc-prolonging activities of Cisapride.Approved, Investigational, Withdrawn
CisplatinThe serum concentration of Cisplatin can be increased when it is combined with Venlafaxine.Approved
CitalopramVenlafaxine may increase the QTc-prolonging activities of Citalopram.Approved
ClarithromycinThe metabolism of Venlafaxine can be decreased when combined with Clarithromycin.Approved
ClemastineThe metabolism of Venlafaxine can be decreased when combined with Clemastine.Approved
ClenbuterolVenlafaxine may increase the tachycardic activities of Clenbuterol.Approved, Vet Approved
ClevidipineThe metabolism of Clevidipine can be decreased when combined with Venlafaxine.Approved
ClidiniumThe risk or severity of adverse effects can be increased when Clidinium is combined with Venlafaxine.Approved
ClindamycinThe metabolism of Clindamycin can be decreased when combined with Venlafaxine.Approved, Vet Approved
ClobazamThe metabolism of Clobazam can be decreased when combined with Venlafaxine.Approved, Illicit
ClofazimineThe metabolism of Clofazimine can be decreased when combined with Venlafaxine.Approved, Investigational
ClofibrateThe metabolism of Clofibrate can be decreased when combined with Venlafaxine.Approved
clomethiazoleThe metabolism of clomethiazole can be decreased when combined with Venlafaxine.Investigational
ClomifeneThe serum concentration of Clomifene can be increased when it is combined with Venlafaxine.Approved, Investigational
ClomipramineThe risk or severity of adverse effects can be increased when Venlafaxine is combined with Clomipramine.Approved, Vet Approved
ClonazepamThe metabolism of Clonazepam can be decreased when combined with Venlafaxine.Approved, Illicit
ClonidineVenlafaxine may increase the tachycardic activities of Clonidine.Approved
ClopidogrelThe metabolism of Clopidogrel can be decreased when combined with Venlafaxine.Approved, Nutraceutical
ClorazepateThe metabolism of Clorazepate can be decreased when combined with Venlafaxine.Approved, Illicit
ClotiazepamThe metabolism of Clotiazepam can be decreased when combined with Venlafaxine.Approved, Illicit
ClotrimazoleThe metabolism of Venlafaxine can be decreased when combined with Clotrimazole.Approved, Vet Approved
ClozapineThe serum concentration of Clozapine can be increased when it is combined with Venlafaxine.Approved
CobicistatThe serum concentration of Venlafaxine can be increased when it is combined with Cobicistat.Approved
CobimetinibThe serum concentration of Cobimetinib can be increased when it is combined with Venlafaxine.Approved
CocaineThe metabolism of Venlafaxine can be decreased when combined with Cocaine.Approved, Illicit
CodeineThe therapeutic efficacy of Codeine can be decreased when used in combination with Venlafaxine.Approved, Illicit
ColchicineThe serum concentration of Colchicine can be increased when it is combined with Venlafaxine.Approved
ColforsinThe serum concentration of Venlafaxine can be increased when it is combined with Colforsin.Experimental
ConivaptanThe serum concentration of Venlafaxine can be increased when it is combined with Conivaptan.Approved, Investigational
Conjugated Equine EstrogensThe metabolism of Conjugated Equine Estrogens can be decreased when combined with Venlafaxine.Approved
Cortisone acetateThe metabolism of Cortisone acetate can be decreased when combined with Venlafaxine.Approved
CrizotinibVenlafaxine may increase the QTc-prolonging activities of Crizotinib.Approved
CyamemazineThe risk or severity of adverse effects can be increased when Venlafaxine is combined with Cyamemazine.Approved
CyclizineThe risk or severity of adverse effects can be increased when Cyclizine is combined with Venlafaxine.Approved
CyclobenzaprineThe risk or severity of adverse effects can be increased when Venlafaxine is combined with Cyclobenzaprine.Approved
CyclophosphamideThe metabolism of Cyclophosphamide can be decreased when combined with Venlafaxine.Approved, Investigational
CyclosporineThe metabolism of Cyclosporine can be decreased when combined with Venlafaxine.Approved, Investigational, Vet Approved
CyproheptadineThe therapeutic efficacy of Venlafaxine can be decreased when used in combination with Cyproheptadine.Approved
CytarabineThe metabolism of Cytarabine can be decreased when combined with Venlafaxine.Approved, Investigational
Dabigatran etexilateThe serum concentration of the active metabolites of Dabigatran etexilate can be increased when Dabigatran etexilate is used in combination with Venlafaxine.Approved
DabrafenibThe serum concentration of Venlafaxine can be decreased when it is combined with Dabrafenib.Approved
DaclatasvirThe metabolism of Daclatasvir can be decreased when combined with Venlafaxine.Approved
DactinomycinThe serum concentration of Venlafaxine can be increased when it is combined with Dactinomycin.Approved
DantroleneThe metabolism of Dantrolene can be decreased when combined with Venlafaxine.Approved
DapagliflozinThe metabolism of Dapagliflozin can be decreased when combined with Venlafaxine.Approved
DapiprazoleThe risk or severity of adverse effects can be increased when Venlafaxine is combined with Dapiprazole.Approved
DapoxetineThe risk or severity of adverse effects can be increased when Dapoxetine is combined with Venlafaxine.Investigational
DapsoneThe metabolism of Dapsone can be decreased when combined with Venlafaxine.Approved, Investigational
DarifenacinThe metabolism of Darifenacin can be decreased when combined with Venlafaxine.Approved, Investigational
DarunavirThe serum concentration of Venlafaxine can be increased when it is combined with Darunavir.Approved
DasabuvirThe metabolism of Dasabuvir can be decreased when combined with Venlafaxine.Approved
DasatinibThe serum concentration of Venlafaxine can be increased when it is combined with Dasatinib.Approved, Investigational
DaunorubicinThe metabolism of Daunorubicin can be decreased when combined with Venlafaxine.Approved
DebrisoquinThe serum concentration of Debrisoquin can be increased when it is combined with Venlafaxine.Approved
DeferasiroxThe serum concentration of Venlafaxine can be decreased when it is combined with Deferasirox.Approved, Investigational
DelavirdineThe metabolism of Venlafaxine can be decreased when combined with Delavirdine.Approved
deramciclaneThe risk or severity of adverse effects can be increased when deramciclane is combined with Venlafaxine.Investigational
DesfluraneThe risk or severity of adverse effects can be increased when Desflurane is combined with Venlafaxine.Approved
DesipramineThe risk or severity of adverse effects can be increased when Venlafaxine is combined with Desipramine.Approved
DesloratadineThe serum concentration of Venlafaxine can be increased when it is combined with Desloratadine.Approved, Investigational
DesmopressinThe risk or severity of adverse effects can be increased when Venlafaxine is combined with Desmopressin.Approved
DesvenlafaxineThe risk or severity of adverse effects can be increased when Venlafaxine is combined with Desvenlafaxine.Approved
DetomidineVenlafaxine may increase the tachycardic activities of Detomidine.Vet Approved
DexamethasoneThe serum concentration of Venlafaxine can be decreased when it is combined with Dexamethasone.Approved, Investigational, Vet Approved
DexbrompheniramineThe risk or severity of adverse effects can be increased when Dexbrompheniramine is combined with Venlafaxine.Approved
DexfenfluramineThe metabolism of Dexfenfluramine can be decreased when combined with Venlafaxine.Approved, Illicit, Withdrawn
DexmedetomidineVenlafaxine may increase the tachycardic activities of Dexmedetomidine.Approved, Vet Approved
DexmethylphenidateThe metabolism of Dexmethylphenidate can be decreased when combined with Venlafaxine.Approved
DextroamphetamineThe metabolism of Dextroamphetamine can be decreased when combined with Venlafaxine.Approved, Illicit
DextromethorphanVenlafaxine may increase the serotonergic activities of Dextromethorphan.Approved
DextromoramideDextromoramide may increase the serotonergic activities of Venlafaxine.Experimental, Illicit
DextropropoxypheneThe metabolism of Dextropropoxyphene can be decreased when combined with Venlafaxine.Approved, Illicit, Withdrawn
DezocineDezocine may increase the serotonergic activities of Venlafaxine.Approved
DiazepamThe metabolism of Diazepam can be decreased when combined with Venlafaxine.Approved, Illicit, Vet Approved
DiclofenacThe metabolism of Diclofenac can be decreased when combined with Venlafaxine.Approved, Vet Approved
DicoumarolThe risk or severity of adverse effects can be increased when Venlafaxine is combined with Dicoumarol.Approved
DiethylstilbestrolThe serum concentration of Diethylstilbestrol can be increased when it is combined with Venlafaxine.Approved
DifenoxinThe risk or severity of adverse effects can be increased when Difenoxin is combined with Venlafaxine.Approved, Illicit
DigitoxinThe metabolism of Digitoxin can be decreased when combined with Venlafaxine.Approved
DigoxinThe metabolism of Digoxin can be decreased when combined with Venlafaxine.Approved
DihydrocodeineThe metabolism of Dihydrocodeine can be decreased when combined with Venlafaxine.Approved, Illicit
DihydroergotamineThe risk or severity of adverse effects can be increased when Venlafaxine is combined with Dihydroergotamine.Approved
DihydroetorphineDihydroetorphine may increase the serotonergic activities of Venlafaxine.Experimental, Illicit
DihydromorphineDihydromorphine may increase the serotonergic activities of Venlafaxine.Experimental, Illicit
DihydrotestosteroneThe serum concentration of Dihydrotestosterone can be increased when it is combined with Venlafaxine.Illicit
DiltiazemThe metabolism of Venlafaxine can be decreased when combined with Diltiazem.Approved
DimenhydrinateThe risk or severity of adverse effects can be increased when Dimenhydrinate is combined with Venlafaxine.Approved
DiphenhydramineThe metabolism of Diphenhydramine can be decreased when combined with Venlafaxine.Approved
DiphenoxylateDiphenoxylate may increase the serotonergic activities of Venlafaxine.Approved, Illicit
DipivefrinVenlafaxine may increase the tachycardic activities of Dipivefrin.Approved
DipyridamoleThe serum concentration of Venlafaxine can be increased when it is combined with Dipyridamole.Approved
DisopyramideVenlafaxine may increase the QTc-prolonging activities of Disopyramide.Approved
DisulfiramThe metabolism of Disulfiram can be decreased when combined with Venlafaxine.Approved
DobutamineVenlafaxine may increase the tachycardic activities of Dobutamine.Approved
DocetaxelThe metabolism of Docetaxel can be decreased when combined with Venlafaxine.Approved, Investigational
DofetilideThe serum concentration of Dofetilide can be increased when it is combined with Venlafaxine.Approved
DolasetronVenlafaxine may increase the QTc-prolonging activities of Dolasetron.Approved
DomperidoneThe serum concentration of Domperidone can be increased when it is combined with Venlafaxine.Approved, Investigational, Vet Approved
DonepezilThe metabolism of Donepezil can be decreased when combined with Venlafaxine.Approved
DopamineThe metabolism of Dopamine can be decreased when combined with Venlafaxine.Approved
DoramectinThe risk or severity of adverse effects can be increased when Doramectin is combined with Venlafaxine.Vet Approved
DorzolamideThe metabolism of Dorzolamide can be decreased when combined with Venlafaxine.Approved
DosulepinThe serum concentration of Dosulepin can be increased when it is combined with Venlafaxine.Approved
DoxazosinThe serum concentration of Venlafaxine can be increased when it is combined with Doxazosin.Approved
DoxepinThe risk or severity of adverse effects can be increased when Venlafaxine is combined with Doxepin.Approved
DoxorubicinThe serum concentration of Doxorubicin can be increased when it is combined with Venlafaxine.Approved, Investigational
DoxorubicinThe metabolism of Doxorubicin can be decreased when combined with Venlafaxine.Approved, Investigational
DoxycyclineThe metabolism of Venlafaxine can be decreased when combined with Doxycycline.Approved, Investigational, Vet Approved
DoxylamineThe risk or severity of adverse effects can be increased when Doxylamine is combined with Venlafaxine.Approved, Vet Approved
DPDPEDPDPE may increase the serotonergic activities of Venlafaxine.Investigational
DronabinolThe serum concentration of Dronabinol can be increased when it is combined with Venlafaxine.Approved, Illicit
DronedaroneVenlafaxine may increase the QTc-prolonging activities of Dronedarone.Approved
DroperidolVenlafaxine may increase the QTc-prolonging activities of Droperidol.Approved, Vet Approved
DrotebanolThe risk or severity of adverse effects can be increased when Drotebanol is combined with Venlafaxine.Experimental, Illicit
DroxidopaVenlafaxine may increase the tachycardic activities of Droxidopa.Approved, Investigational
DulaglutideVenlafaxine may increase the hypoglycemic activities of Dulaglutide.Approved
DuloxetineThe risk or severity of adverse effects can be increased when Venlafaxine is combined with Duloxetine.Approved
DutasterideThe metabolism of Dutasteride can be decreased when combined with Venlafaxine.Approved, Investigational
DyclonineThe risk or severity of adverse effects can be increased when Dyclonine is combined with Venlafaxine.Approved
EcgonineThe risk or severity of adverse effects can be increased when Ecgonine is combined with Venlafaxine.Experimental, Illicit
ECGONINE METHYL ESTERThe risk or severity of adverse effects can be increased when ECGONINE METHYL ESTER is combined with Venlafaxine.Experimental
EcopipamThe risk or severity of adverse effects can be increased when Venlafaxine is combined with Ecopipam.Investigational
EdoxabanThe serum concentration of Edoxaban can be increased when it is combined with Venlafaxine.Approved
EfavirenzThe serum concentration of Venlafaxine can be decreased when it is combined with Efavirenz.Approved, Investigational
ElbasvirThe serum concentration of Venlafaxine can be increased when it is combined with Elbasvir.Approved
EletriptanThe serum concentration of Eletriptan can be increased when it is combined with Venlafaxine.Approved, Investigational
EliglustatThe serum concentration of Eliglustat can be increased when it is combined with Venlafaxine.Approved
ElvitegravirThe metabolism of Elvitegravir can be decreased when combined with Venlafaxine.Approved
EmpagliflozinVenlafaxine may increase the hypoglycemic activities of Empagliflozin.Approved
EnalaprilThe metabolism of Enalapril can be decreased when combined with Venlafaxine.Approved, Vet Approved
EncainideThe metabolism of Encainide can be decreased when combined with Venlafaxine.Approved, Withdrawn
EnclomipheneThe metabolism of Enclomiphene can be decreased when combined with Venlafaxine.Investigational
EnfluraneThe risk or severity of adverse effects can be increased when Enflurane is combined with Venlafaxine.Approved, Vet Approved
EntacaponeThe risk or severity of adverse effects can be increased when Entacapone is combined with Venlafaxine.Approved, Investigational
EnzalutamideThe serum concentration of Venlafaxine can be decreased when it is combined with Enzalutamide.Approved
EphedraVenlafaxine may decrease the antihypertensive activities of Ephedra.Approved, Nutraceutical, Withdrawn
EphedrineVenlafaxine may increase the tachycardic activities of Ephedrine.Approved
EpinastineThe metabolism of Epinastine can be decreased when combined with Venlafaxine.Approved, Investigational
EpinephrineVenlafaxine may increase the tachycardic activities of Epinephrine.Approved, Vet Approved
EplerenoneThe serum concentration of Eplerenone can be increased when it is combined with Venlafaxine.Approved
ErgocalciferolThe metabolism of Ergocalciferol can be decreased when combined with Venlafaxine.Approved, Nutraceutical
Ergoloid mesylateThe risk or severity of adverse effects can be increased when Venlafaxine is combined with Ergoloid mesylate.Approved
ErgonovineThe risk or severity of adverse effects can be increased when Venlafaxine is combined with Ergonovine.Approved
ErgotamineThe risk or severity of adverse effects can be increased when Venlafaxine is combined with Ergotamine.Approved
ErlotinibThe metabolism of Erlotinib can be decreased when combined with Venlafaxine.Approved, Investigational
ErythromycinVenlafaxine may increase the QTc-prolonging activities of Erythromycin.Approved, Vet Approved
EscitalopramVenlafaxine may increase the QTc-prolonging activities of Escitalopram.Approved, Investigational
Eslicarbazepine acetateThe serum concentration of Venlafaxine can be decreased when it is combined with Eslicarbazepine acetate.Approved
EsmirtazapineThe metabolism of Esmirtazapine can be decreased when combined with Venlafaxine.Investigational
EsmololThe serum concentration of Esmolol can be increased when it is combined with Venlafaxine.Approved
EsomeprazoleThe metabolism of Esomeprazole can be decreased when combined with Venlafaxine.Approved, Investigational
EstazolamThe metabolism of Estazolam can be decreased when combined with Venlafaxine.Approved, Illicit
EstradiolThe metabolism of Estradiol can be decreased when combined with Venlafaxine.Approved, Investigational, Vet Approved
Estradiol valerate/DienogestThe metabolism of Estradiol valerate/Dienogest can be decreased when combined with Venlafaxine.Approved
EstramustineThe metabolism of Estramustine can be decreased when combined with Venlafaxine.Approved
EstriolThe serum concentration of Venlafaxine can be decreased when it is combined with Estriol.Approved, Vet Approved
EstroneThe metabolism of Estrone can be decreased when combined with Venlafaxine.Approved
Estrone sulfateThe metabolism of Estrone sulfate can be decreased when combined with Venlafaxine.Approved
EszopicloneThe metabolism of Eszopiclone can be decreased when combined with Venlafaxine.Approved
EthanolThe risk or severity of adverse effects can be increased when Ethanol is combined with Venlafaxine.Approved
EthchlorvynolThe risk or severity of adverse effects can be increased when Ethchlorvynol is combined with Venlafaxine.Approved, Illicit, Withdrawn
Ethinyl EstradiolThe metabolism of Ethinyl Estradiol can be decreased when combined with Venlafaxine.Approved
EthosuximideThe metabolism of Ethosuximide can be decreased when combined with Venlafaxine.Approved
EthotoinThe risk or severity of adverse effects can be increased when Ethotoin is combined with Venlafaxine.Approved
Ethyl biscoumacetateThe risk or severity of adverse effects can be increased when Venlafaxine is combined with Ethyl biscoumacetate.Withdrawn
Ethyl carbamateThe risk or severity of adverse effects can be increased when Ethyl carbamate is combined with Venlafaxine.Withdrawn
Ethyl loflazepateThe risk or severity of adverse effects can be increased when Ethyl loflazepate is combined with Venlafaxine.Approved, Illicit
EthylmorphineThe metabolism of Ethylmorphine can be decreased when combined with Venlafaxine.Approved, Illicit
EtidocaineThe risk or severity of adverse effects can be increased when Etidocaine is combined with Venlafaxine.Approved
EtifoxineThe risk or severity of adverse effects can be increased when Etifoxine is combined with Venlafaxine.Withdrawn
EtilefrineVenlafaxine may increase the tachycardic activities of Etilefrine.Withdrawn
EtizolamThe risk or severity of adverse effects can be increased when Etizolam is combined with Venlafaxine.Approved
EtodolacVenlafaxine may increase the antiplatelet activities of Etodolac.Approved, Investigational, Vet Approved
EtomidateVenlafaxine may decrease the antihypertensive activities of Etomidate.Approved
EtonogestrelThe metabolism of Etonogestrel can be decreased when combined with Venlafaxine.Approved, Investigational
EtoperidoneVenlafaxine may increase the serotonergic activities of Etoperidone.Approved
EtoposideThe metabolism of Etoposide can be decreased when combined with Venlafaxine.Approved
EtoricoxibVenlafaxine may increase the antiplatelet activities of Etoricoxib.Approved, Investigational
EtorphineEtorphine may increase the serotonergic activities of Venlafaxine.Illicit, Vet Approved
EtravirineThe serum concentration of Venlafaxine can be decreased when it is combined with Etravirine.Approved
EverolimusThe serum concentration of Everolimus can be increased when it is combined with Venlafaxine.Approved
ExemestaneThe metabolism of Exemestane can be decreased when combined with Venlafaxine.Approved, Investigational
ExenatideVenlafaxine may increase the hypoglycemic activities of Exenatide.Approved, Investigational
EzetimibeThe serum concentration of Ezetimibe can be increased when it is combined with Venlafaxine.Approved
EzogabineThe risk or severity of adverse effects can be increased when Ezogabine is combined with Venlafaxine.Approved
FamciclovirThe metabolism of Famciclovir can be decreased when combined with Venlafaxine.Approved
FelbamateThe metabolism of Felbamate can be decreased when combined with Venlafaxine.Approved
FelodipineThe metabolism of Felodipine can be decreased when combined with Venlafaxine.Approved, Investigational
FencamfamineThe risk or severity of adverse effects can be increased when Venlafaxine is combined with Fencamfamine.Approved, Illicit, Withdrawn
FenfluramineVenlafaxine may increase the serotonergic activities of Fenfluramine.Illicit, Withdrawn
FenofibrateThe metabolism of Fenofibrate can be decreased when combined with Venlafaxine.Approved
FenoterolVenlafaxine may increase the tachycardic activities of Fenoterol.Approved
FentanylThe serum concentration of Fentanyl can be increased when it is combined with Venlafaxine.Approved, Illicit, Investigational, Vet Approved
FesoterodineThe serum concentration of the active metabolites of Fesoterodine can be increased when Fesoterodine is used in combination with Venlafaxine.Approved
FexofenadineThe serum concentration of Fexofenadine can be increased when it is combined with Venlafaxine.Approved
FidaxomicinThe serum concentration of Fidaxomicin can be increased when it is combined with Venlafaxine.Approved
FinasterideThe metabolism of Finasteride can be decreased when combined with Venlafaxine.Approved
FingolimodThe metabolism of Fingolimod can be decreased when combined with Venlafaxine.Approved, Investigational
FlecainideVenlafaxine may increase the QTc-prolonging activities of Flecainide.Approved, Withdrawn
FlibanserinThe serum concentration of Flibanserin can be increased when it is combined with Venlafaxine.Approved
FloxuridineThe metabolism of Venlafaxine can be decreased when combined with Floxuridine.Approved
FluconazoleThe metabolism of Venlafaxine can be decreased when combined with Fluconazole.Approved
FludiazepamThe risk or severity of adverse effects can be increased when Fludiazepam is combined with Venlafaxine.Approved, Illicit
FluindioneThe risk or severity of adverse effects can be increased when Venlafaxine is combined with Fluindione.Investigational
FlunarizineThe metabolism of Flunarizine can be decreased when combined with Venlafaxine.Approved
FlunisolideThe metabolism of Flunisolide can be decreased when combined with Venlafaxine.Approved, Investigational
FlunitrazepamThe metabolism of Flunitrazepam can be decreased when combined with Venlafaxine.Approved, Illicit
FluorometholoneThe metabolism of Fluorometholone can be decreased when combined with Venlafaxine.Approved
FluorouracilThe metabolism of Venlafaxine can be decreased when combined with Fluorouracil.Approved
FluoxetineVenlafaxine may increase the QTc-prolonging activities of Fluoxetine.Approved, Vet Approved
FlupentixolVenlafaxine may increase the QTc-prolonging activities of Flupentixol.Approved, Withdrawn
FluphenazineThe serum concentration of Venlafaxine can be increased when it is combined with Fluphenazine.Approved
FlurazepamThe metabolism of Flurazepam can be decreased when combined with Venlafaxine.Approved, Illicit
FluspirileneThe risk or severity of adverse effects can be increased when Venlafaxine is combined with Fluspirilene.Approved
FlutamideThe metabolism of Flutamide can be decreased when combined with Venlafaxine.Approved
Fluticasone furoateThe metabolism of Fluticasone furoate can be decreased when combined with Venlafaxine.Approved
Fluticasone PropionateThe metabolism of Fluticasone Propionate can be decreased when combined with Venlafaxine.Approved
FluvastatinThe metabolism of Fluvastatin can be decreased when combined with Venlafaxine.Approved
FluvoxamineThe metabolism of Venlafaxine can be decreased when combined with Fluvoxamine.Approved, Investigational
FormoterolVenlafaxine may increase the tachycardic activities of Formoterol.Approved, Investigational
FosamprenavirThe metabolism of Fosamprenavir can be decreased when combined with Venlafaxine.Approved
FosaprepitantThe serum concentration of Venlafaxine can be increased when it is combined with Fosaprepitant.Approved
FosphenytoinThe metabolism of Venlafaxine can be increased when combined with Fosphenytoin.Approved
FospropofolThe risk or severity of adverse effects can be increased when Fospropofol is combined with Venlafaxine.Approved, Illicit
FrovatriptanThe risk or severity of adverse effects can be increased when Venlafaxine is combined with Frovatriptan.Approved, Investigational
FulvestrantThe metabolism of Fulvestrant can be decreased when combined with Venlafaxine.Approved, Investigational
FurazolidoneFurazolidone may increase the serotonergic activities of Venlafaxine.Approved, Vet Approved
Fusidic AcidThe serum concentration of Venlafaxine can be increased when it is combined with Fusidic Acid.Approved
GabapentinThe risk or severity of adverse effects can be increased when Gabapentin is combined with Venlafaxine.Approved, Investigational
gabapentin enacarbilThe risk or severity of adverse effects can be increased when gabapentin enacarbil is combined with Venlafaxine.Approved
Gadobenic acidVenlafaxine may increase the QTc-prolonging activities of Gadobenic acid.Approved
GalantamineThe metabolism of Galantamine can be decreased when combined with Venlafaxine.Approved
Gamma Hydroxybutyric AcidThe risk or severity of adverse effects can be increased when Gamma Hydroxybutyric Acid is combined with Venlafaxine.Approved, Illicit
GefitinibThe metabolism of Gefitinib can be decreased when combined with Venlafaxine.Approved, Investigational
GemcitabineThe serum concentration of Gemcitabine can be increased when it is combined with Venlafaxine.Approved
GemfibrozilThe metabolism of Venlafaxine can be decreased when combined with Gemfibrozil.Approved
GemifloxacinVenlafaxine may increase the QTc-prolonging activities of Gemifloxacin.Approved, Investigational
GenisteinThe serum concentration of Venlafaxine can be increased when it is combined with Genistein.Investigational
GepironeThe risk or severity of adverse effects can be increased when Gepirone is combined with Venlafaxine.Investigational
GliclazideVenlafaxine may increase the hypoglycemic activities of Gliclazide.Approved
GlimepirideVenlafaxine may increase the hypoglycemic activities of Glimepiride.Approved
GlipizideThe metabolism of Glipizide can be decreased when combined with Venlafaxine.Approved
GlutethimideThe risk or severity of adverse effects can be increased when Glutethimide is combined with Venlafaxine.Approved, Illicit
GlyburideThe metabolism of Glyburide can be decreased when combined with Venlafaxine.Approved
GlycerolThe serum concentration of Venlafaxine can be increased when it is combined with Glycerol.Experimental
GoserelinVenlafaxine may increase the QTc-prolonging activities of Goserelin.Approved
Gramicidin DThe serum concentration of Venlafaxine can be increased when it is combined with Gramicidin D.Approved
GranisetronVenlafaxine may increase the QTc-prolonging activities of Granisetron.Approved, Investigational
GrazoprevirThe serum concentration of Grazoprevir can be increased when it is combined with Venlafaxine.Approved
GrepafloxacinThe metabolism of Grepafloxacin can be decreased when combined with Venlafaxine.Withdrawn
GuanabenzVenlafaxine may increase the tachycardic activities of Guanabenz.Approved
GuanfacineVenlafaxine may increase the tachycardic activities of Guanfacine.Approved, Investigational
HalazepamThe risk or severity of adverse effects can be increased when Halazepam is combined with Venlafaxine.Approved, Illicit, Withdrawn
HalofantrineThe serum concentration of Halofantrine can be increased when it is combined with Venlafaxine.Approved
HaloperidolVenlafaxine may increase the QTc-prolonging activities of Haloperidol.Approved
HalothaneThe metabolism of Halothane can be decreased when combined with Venlafaxine.Approved, Vet Approved
HeroinHeroin may increase the serotonergic activities of Venlafaxine.Approved, Illicit
HexobarbitalThe metabolism of Hexobarbital can be decreased when combined with Venlafaxine.Approved
HexoprenalineVenlafaxine may increase the tachycardic activities of Hexoprenaline.Approved, Withdrawn
HigenamineVenlafaxine may increase the tachycardic activities of Higenamine.Investigational
Histamine PhosphateThe metabolism of Histamine Phosphate can be decreased when combined with Venlafaxine.Approved
HydracarbazineHydracarbazine may increase the serotonergic activities of Venlafaxine.Approved
HydrochlorothiazideVenlafaxine may increase the hyponatremic activities of Hydrochlorothiazide.Approved, Vet Approved
HydrocodoneThe serum concentration of Hydrocodone can be increased when it is combined with Venlafaxine.Approved, Illicit
HydrocortisoneThe metabolism of Hydrocortisone can be decreased when combined with Venlafaxine.Approved, Vet Approved
HydroflumethiazideVenlafaxine may increase the hyponatremic activities of Hydroflumethiazide.Approved
HydromorphoneThe metabolism of Hydromorphone can be decreased when combined with Venlafaxine.Approved, Illicit
Hydroxyprogesterone caproateThe metabolism of Hydroxyprogesterone caproate can be decreased when combined with Venlafaxine.Approved
HydroxyzineThe risk or severity of adverse effects can be increased when Hydroxyzine is combined with Venlafaxine.Approved
IbrutinibThe serum concentration of Ibrutinib can be increased when it is combined with Venlafaxine.Approved
IbuprofenThe serum concentration of Ibuprofen can be increased when it is combined with Venlafaxine.Approved
IbutilideVenlafaxine may increase the QTc-prolonging activities of Ibutilide.Approved
IdarubicinThe metabolism of Idarubicin can be decreased when combined with Venlafaxine.Approved
IdelalisibThe serum concentration of Venlafaxine can be increased when it is combined with Idelalisib.Approved
IfosfamideThe serum concentration of the active metabolites of Ifosfamide can be reduced when Ifosfamide is used in combination with Venlafaxine resulting in a loss in efficacy.Approved
IloperidoneVenlafaxine may increase the QTc-prolonging activities of Iloperidone.Approved
ImatinibThe serum concentration of Imatinib can be increased when it is combined with Venlafaxine.Approved
ImipramineThe risk or severity of adverse effects can be increased when Venlafaxine is combined with Imipramine.Approved
ImiquimodThe metabolism of Imiquimod can be decreased when combined with Venlafaxine.Approved, Investigational
IndacaterolThe metabolism of Indacaterol can be decreased when combined with Venlafaxine.Approved
IndalpineVenlafaxine may increase the serotonergic activities of Indalpine.Investigational, Withdrawn
IndapamideThe metabolism of Indapamide can be decreased when combined with Venlafaxine.Approved
IndenololThe serum concentration of Indenolol can be increased when it is combined with Venlafaxine.Withdrawn
IndinavirThe serum concentration of Indinavir can be decreased when it is combined with Venlafaxine.Approved
IndomethacinThe serum concentration of Venlafaxine can be increased when it is combined with Indomethacin.Approved, Investigational
Insulin AspartVenlafaxine may increase the hypoglycemic activities of Insulin Aspart.Approved
Insulin DetemirVenlafaxine may increase the hypoglycemic activities of Insulin Detemir.Approved
Insulin GlargineVenlafaxine may increase the hypoglycemic activities of Insulin Glargine.Approved
Insulin GlulisineVenlafaxine may increase the hypoglycemic activities of Insulin Glulisine.Approved
Insulin HumanVenlafaxine may increase the hypoglycemic activities of Insulin Human.Approved, Investigational
Insulin LisproVenlafaxine may increase the hypoglycemic activities of Insulin Lispro.Approved
IobenguaneThe therapeutic efficacy of Iobenguane can be decreased when used in combination with Venlafaxine.Approved
Ioflupane I-123Venlafaxine may decrease effectiveness of Ioflupane I-123 as a diagnostic agent.Approved
Ipratropium bromideThe metabolism of Ipratropium bromide can be decreased when combined with Venlafaxine.Approved
IproclozideIproclozide may increase the serotonergic activities of Venlafaxine.Withdrawn
IproniazidIproniazid may increase the serotonergic activities of Venlafaxine.Withdrawn
IrbesartanThe metabolism of Venlafaxine can be decreased when combined with Irbesartan.Approved, Investigational
IrinotecanThe metabolism of Irinotecan can be decreased when combined with Venlafaxine.Approved, Investigational
IsavuconazoniumThe metabolism of Isavuconazonium can be decreased when combined with Venlafaxine.Approved, Investigational
IsocarboxazidIsocarboxazid may increase the serotonergic activities of Venlafaxine.Approved
IsoetarineVenlafaxine may increase the tachycardic activities of Isoetarine.Approved
IsofluraneThe metabolism of Isoflurane can be decreased when combined with Venlafaxine.Approved, Vet Approved
IsoniazidThe metabolism of Venlafaxine can be decreased when combined with Isoniazid.Approved
IsoprenalineVenlafaxine may increase the tachycardic activities of Isoprenaline.Approved
Isosorbide DinitrateThe metabolism of Isosorbide Dinitrate can be decreased when combined with Venlafaxine.Approved
Isosorbide MononitrateThe metabolism of Isosorbide Mononitrate can be decreased when combined with Venlafaxine.Approved
IsoxsuprineVenlafaxine may increase the tachycardic activities of Isoxsuprine.Approved, Withdrawn
IsradipineThe metabolism of Venlafaxine can be decreased when combined with Isradipine.Approved
ItraconazoleThe metabolism of Venlafaxine can be decreased when combined with Itraconazole.Approved, Investigational
IvabradineThe serum concentration of Ivabradine can be increased when it is combined with Venlafaxine.Approved
IvacaftorThe serum concentration of Ivacaftor can be increased when it is combined with Venlafaxine.Approved
IvermectinThe metabolism of Ivermectin can be decreased when combined with Venlafaxine.Approved, Vet Approved
IxabepiloneThe metabolism of Ixabepilone can be decreased when combined with Venlafaxine.Approved, Investigational
IxazomibThe metabolism of Ixazomib can be decreased when combined with Venlafaxine.Approved
KetamineThe metabolism of Ketamine can be decreased when combined with Venlafaxine.Approved, Vet Approved
KetazolamThe metabolism of Ketazolam can be decreased when combined with Venlafaxine.Approved
KetobemidoneThe metabolism of Ketobemidone can be decreased when combined with Venlafaxine.Approved
KetoconazoleThe metabolism of Venlafaxine can be decreased when combined with Ketoconazole.Approved, Investigational
L-TryptophanL-Tryptophan may increase the serotonergic activities of Venlafaxine.Approved, Nutraceutical
LabetalolThe metabolism of Labetalol can be decreased when combined with Venlafaxine.Approved
LamivudineThe serum concentration of Lamivudine can be increased when it is combined with Venlafaxine.Approved, Investigational
LamotrigineThe serum concentration of Lamotrigine can be increased when it is combined with Venlafaxine.Approved, Investigational
LanreotideVenlafaxine may increase the hypoglycemic activities of Lanreotide.Approved
LansoprazoleThe metabolism of Lansoprazole can be decreased when combined with Venlafaxine.Approved, Investigational
LapatinibThe metabolism of Lapatinib can be decreased when combined with Venlafaxine.Approved, Investigational
LaquinimodThe metabolism of Laquinimod can be decreased when combined with Venlafaxine.Investigational
LedipasvirThe serum concentration of Ledipasvir can be increased when it is combined with Venlafaxine.Approved
LeflunomideThe metabolism of Venlafaxine can be decreased when combined with Leflunomide.Approved, Investigational
LenalidomideThe serum concentration of Lenalidomide can be increased when it is combined with Venlafaxine.Approved
LenvatinibVenlafaxine may increase the QTc-prolonging activities of Lenvatinib.Approved
LercanidipineThe metabolism of Lercanidipine can be decreased when combined with Venlafaxine.Approved, Investigational
LetrozoleThe metabolism of Letrozole can be decreased when combined with Venlafaxine.Approved, Investigational
LeuprolideVenlafaxine may increase the QTc-prolonging activities of Leuprolide.Approved, Investigational
LevetiracetamThe serum concentration of Levetiracetam can be increased when it is combined with Venlafaxine.Approved, Investigational
LevobunololThe serum concentration of Levobunolol can be increased when it is combined with Venlafaxine.Approved
LevobupivacaineThe metabolism of Levobupivacaine can be decreased when combined with Venlafaxine.Approved
LevocabastineThe risk or severity of adverse effects can be increased when Levocabastine is combined with Venlafaxine.Approved
LevocetirizineThe metabolism of Levocetirizine can be decreased when combined with Venlafaxine.Approved
LevodopaThe metabolism of Levodopa can be decreased when combined with Venlafaxine.Approved
LevofloxacinVenlafaxine may increase the QTc-prolonging activities of Levofloxacin.Approved, Investigational
Levomethadyl AcetateThe metabolism of Levomethadyl Acetate can be decreased when combined with Venlafaxine.Approved
LevomilnacipranThe risk or severity of adverse effects can be increased when Venlafaxine is combined with Levomilnacipran.Approved
LevonorgestrelThe metabolism of Levonorgestrel can be decreased when combined with Venlafaxine.Approved, Investigational
LevorphanolLevorphanol may increase the serotonergic activities of Venlafaxine.Approved
LevothyroxineThe metabolism of Levothyroxine can be decreased when combined with Venlafaxine.Approved
LidocaineThe metabolism of Lidocaine can be decreased when combined with Venlafaxine.Approved, Vet Approved
LinagliptinThe serum concentration of Linagliptin can be increased when it is combined with Venlafaxine.Approved
LinezolidLinezolid may increase the serotonergic activities of Venlafaxine.Approved, Investigational
LiothyronineThe serum concentration of Venlafaxine can be decreased when it is combined with Liothyronine.Approved, Vet Approved
LiotrixThe serum concentration of Venlafaxine can be decreased when it is combined with Liotrix.Approved
LiraglutideVenlafaxine may increase the hypoglycemic activities of Liraglutide.Approved
LisinoprilThe serum concentration of Venlafaxine can be increased when it is combined with Lisinopril.Approved, Investigational
LisurideThe metabolism of Lisuride can be decreased when combined with Venlafaxine.Approved
LithiumLithium may increase the serotonergic activities of Venlafaxine.Approved
LofentanilLofentanil may increase the serotonergic activities of Venlafaxine.Illicit
LofexidineVenlafaxine may increase the tachycardic activities of Lofexidine.Approved, Investigational
LomitapideThe serum concentration of Lomitapide can be increased when it is combined with Venlafaxine.Approved
LomustineThe metabolism of Lomustine can be decreased when combined with Venlafaxine.Approved
LoperamideThe metabolism of Loperamide can be decreased when combined with Venlafaxine.Approved
LopinavirThe metabolism of Venlafaxine can be decreased when combined with Lopinavir.Approved
LoratadineThe metabolism of Loratadine can be decreased when combined with Venlafaxine.Approved
LorazepamThe risk or severity of adverse effects can be increased when Lorazepam is combined with Venlafaxine.Approved
LorcaserinThe risk or severity of adverse effects can be increased when Venlafaxine is combined with Lorcaserin.Approved
LosartanThe metabolism of Losartan can be decreased when combined with Venlafaxine.Approved
LovastatinThe metabolism of Venlafaxine can be decreased when combined with Lovastatin.Approved, Investigational
LoxapineThe risk or severity of adverse effects can be increased when Venlafaxine is combined with Loxapine.Approved
Lu AA21004Venlafaxine may increase the serotonergic activities of Lu AA21004.Investigational
LuliconazoleThe serum concentration of Venlafaxine can be increased when it is combined with Luliconazole.Approved
LumacaftorThe serum concentration of Venlafaxine can be decreased when it is combined with Lumacaftor.Approved
LumefantrineVenlafaxine may increase the QTc-prolonging activities of Lumefantrine.Approved
LumiracoxibVenlafaxine may increase the antiplatelet activities of Lumiracoxib.Approved, Investigational
LurasidoneThe serum concentration of Lurasidone can be increased when it is combined with Venlafaxine.Approved
MacitentanThe metabolism of Macitentan can be decreased when combined with Venlafaxine.Approved
Magnesium SulfateThe risk or severity of adverse effects can be increased when Magnesium Sulfate is combined with Venlafaxine.Approved, Vet Approved
MalathionThe metabolism of Malathion can be decreased when combined with Venlafaxine.Approved, Investigational
MannitolThe serum concentration of Mannitol can be increased when it is combined with Venlafaxine.Approved, Investigational
MaprotilineThe risk or severity of adverse effects can be increased when Venlafaxine is combined with Maprotiline.Approved
MaravirocThe metabolism of Maraviroc can be decreased when combined with Venlafaxine.Approved, Investigational
MebanazineMebanazine may increase the serotonergic activities of Venlafaxine.Withdrawn
MebendazoleThe metabolism of Mebendazole can be decreased when combined with Venlafaxine.Approved, Vet Approved
MecaserminVenlafaxine may increase the hypoglycemic activities of Mecasermin.Approved, Investigational
MeclizineThe risk or severity of adverse effects can be increased when Meclizine is combined with Venlafaxine.Approved
MedetomidineVenlafaxine may increase the tachycardic activities of Medetomidine.Vet Approved
Medroxyprogesterone acetateThe metabolism of Medroxyprogesterone acetate can be decreased when combined with Venlafaxine.Approved, Investigational
MefloquineThe metabolism of Mefloquine can be decreased when combined with Venlafaxine.Approved
Megestrol acetateThe serum concentration of Venlafaxine can be increased when it is combined with Megestrol acetate.Approved, Vet Approved
MelatoninThe risk or severity of adverse effects can be increased when Melatonin is combined with Venlafaxine.Approved, Nutraceutical, Vet Approved
MeloxicamThe metabolism of Meloxicam can be decreased when combined with Venlafaxine.Approved, Vet Approved
MelperoneThe risk or severity of adverse effects can be increased when Venlafaxine is combined with Melperone.Approved
MephentermineVenlafaxine may increase the tachycardic activities of Mephentermine.Approved
MephenytoinThe metabolism of Mephenytoin can be decreased when combined with Venlafaxine.Investigational, Withdrawn
MepivacaineThe risk or severity of adverse effects can be increased when Mepivacaine is combined with Venlafaxine.Approved, Vet Approved
MeprobamateThe serum concentration of Venlafaxine can be increased when it is combined with Meprobamate.Approved, Illicit
MequitazineThe metabolism of Mequitazine can be decreased when combined with Venlafaxine.Approved
MesoridazineThe metabolism of Mesoridazine can be decreased when combined with Venlafaxine.Approved
MetaraminolVenlafaxine may increase the tachycardic activities of Metaraminol.Approved, Investigational
MetaxaloneThe risk or severity of adverse effects can be increased when Metaxalone is combined with Venlafaxine.Approved
MetforminVenlafaxine may increase the hypoglycemic activities of Metformin.Approved
MethadoneThe metabolism of Methadone can be decreased when combined with Venlafaxine.Approved
Methadyl AcetateMethadyl Acetate may increase the serotonergic activities of Venlafaxine.Approved, Illicit
MethamphetamineThe metabolism of Methamphetamine can be decreased when combined with Venlafaxine.Approved, Illicit
MethapyrileneThe risk or severity of adverse effects can be increased when Methapyrilene is combined with Venlafaxine.Withdrawn
MethaqualoneThe metabolism of Methaqualone can be decreased when combined with Venlafaxine.Illicit, Withdrawn
MethocarbamolThe risk or severity of adverse effects can be increased when Methocarbamol is combined with Venlafaxine.Approved, Vet Approved
MethohexitalThe risk or severity of adverse effects can be increased when Methohexital is combined with Venlafaxine.Approved
MethotrexateThe serum concentration of Methotrexate can be increased when it is combined with Venlafaxine.Approved
MethotrimeprazineThe metabolism of Venlafaxine can be decreased when combined with Methotrimeprazine.Approved
MethoxamineVenlafaxine may increase the tachycardic activities of Methoxamine.Approved
MethoxsalenThe metabolism of Methoxsalen can be decreased when combined with Venlafaxine.Approved
MethoxyfluraneThe metabolism of Methoxyflurane can be decreased when combined with Venlafaxine.Approved, Vet Approved
MethsuximideThe risk or severity of adverse effects can be increased when Methsuximide is combined with Venlafaxine.Approved
MethyclothiazideVenlafaxine may increase the hyponatremic activities of Methyclothiazide.Approved
MethyldopaVenlafaxine may increase the tachycardic activities of Methyldopa.Approved
Methylene blueVenlafaxine may increase the serotonergic activities of Methylene blue.Investigational
MethylphenidateThe metabolism of Methylphenidate can be decreased when combined with Venlafaxine.Approved, Investigational
MethylphenobarbitalThe metabolism of Methylphenobarbital can be decreased when combined with Venlafaxine.Approved
MethylprednisoloneThe metabolism of Methylprednisolone can be decreased when combined with Venlafaxine.Approved, Vet Approved
MethyltestosteroneThe metabolism of Methyltestosterone can be decreased when combined with Venlafaxine.Approved
MethyprylonThe metabolism of Methyprylon can be decreased when combined with Venlafaxine.Approved, Illicit, Withdrawn
MetipranololThe serum concentration of Metipranolol can be increased when it is combined with Venlafaxine.Approved
MetoclopramideThe risk or severity of adverse effects can be increased when Metoclopramide is combined with Venlafaxine.Approved, Investigational
MetolazoneVenlafaxine may increase the hyponatremic activities of Metolazone.Approved
MetoprololThe serum concentration of Metoprolol can be increased when it is combined with Venlafaxine.Approved, Investigational
MetronidazoleThe metabolism of Metronidazole can be decreased when combined with Venlafaxine.Approved
MetyrosineThe risk or severity of adverse effects can be increased when Metyrosine is combined with Venlafaxine.Approved
MexiletineThe metabolism of Mexiletine can be decreased when combined with Venlafaxine.Approved
MianserinThe metabolism of Mianserin can be decreased when combined with Venlafaxine.Approved
MibefradilThe metabolism of Mibefradil can be decreased when combined with Venlafaxine.Withdrawn
MiconazoleThe metabolism of Miconazole can be decreased when combined with Venlafaxine.Approved, Investigational, Vet Approved
MidazolamThe metabolism of Midazolam can be decreased when combined with Venlafaxine.Approved, Illicit
MidodrineVenlafaxine may increase the tachycardic activities of Midodrine.Approved
MifepristoneThe serum concentration of Venlafaxine can be increased when it is combined with Mifepristone.Approved, Investigational
MiglitolVenlafaxine may increase the hypoglycemic activities of Miglitol.Approved
MilnacipranThe risk or severity of adverse effects can be increased when Venlafaxine is combined with Milnacipran.Approved
MinaprineMinaprine may increase the serotonergic activities of Venlafaxine.Approved
MirabegronVenlafaxine may increase the tachycardic activities of Mirabegron.Approved
MirtazapineThe risk or severity of adverse effects can be increased when Venlafaxine is combined with Mirtazapine.Approved
MitomycinThe serum concentration of Venlafaxine can be increased when it is combined with Mitomycin.Approved
MitotaneThe serum concentration of Venlafaxine can be decreased when it is combined with Mitotane.Approved
MitoxantroneThe serum concentration of Venlafaxine can be decreased when it is combined with Mitoxantrone.Approved, Investigational
MoclobemideMoclobemide may increase the serotonergic activities of Venlafaxine.Approved
ModafinilThe serum concentration of Venlafaxine can be decreased when it is combined with Modafinil.Approved, Investigational
MolindoneThe risk or severity of adverse effects can be increased when Venlafaxine is combined with Molindone.Approved
MontelukastThe metabolism of Montelukast can be decreased when combined with Venlafaxine.Approved
MorphineThe metabolism of Morphine can be decreased when combined with Venlafaxine.Approved, Investigational
MoxifloxacinVenlafaxine may increase the QTc-prolonging activities of Moxifloxacin.Approved, Investigational
Mycophenolate mofetilThe metabolism of Mycophenolate mofetil can be decreased when combined with Venlafaxine.Approved, Investigational
NabiloneThe risk or severity of adverse effects can be increased when Nabilone is combined with Venlafaxine.Approved, Investigational
NabumetoneVenlafaxine may increase the antiplatelet activities of Nabumetone.Approved
NadololThe serum concentration of Nadolol can be increased when it is combined with Venlafaxine.Approved
NafcillinThe serum concentration of Venlafaxine can be decreased when it is combined with Nafcillin.Approved
NalbuphineNalbuphine may increase the serotonergic activities of Venlafaxine.Approved
NaloxegolThe serum concentration of Naloxegol can be increased when it is combined with Venlafaxine.Approved
NaloxoneThe metabolism of Naloxone can be decreased when combined with Venlafaxine.Approved, Vet Approved
NaltrexoneThe serum concentration of Venlafaxine can be increased when it is combined with Naltrexone.Approved, Investigational, Vet Approved
NaphazolineVenlafaxine may increase the tachycardic activities of Naphazoline.Approved
NaratriptanThe risk or severity of adverse effects can be increased when Venlafaxine is combined with Naratriptan.Approved, Investigational
NaringeninThe serum concentration of Venlafaxine can be increased when it is combined with Naringenin.Experimental
NateglinideThe metabolism of Nateglinide can be decreased when combined with Venlafaxine.Approved, Investigational
NebivololThe serum concentration of Nebivolol can be increased when it is combined with Venlafaxine.Approved, Investigational
NefazodoneThe metabolism of Venlafaxine can be decreased when combined with Nefazodone.Approved, Withdrawn
NelfinavirThe metabolism of Venlafaxine can be decreased when combined with Nelfinavir.Approved
NeostigmineThe serum concentration of Venlafaxine can be increased when it is combined with Neostigmine.Approved, Vet Approved
NetupitantThe serum concentration of Venlafaxine can be increased when it is combined with Netupitant.Approved
NevirapineThe metabolism of Venlafaxine can be increased when combined with Nevirapine.Approved
NialamideNialamide may increase the serotonergic activities of Venlafaxine.Withdrawn
NicardipineThe metabolism of Venlafaxine can be decreased when combined with Nicardipine.Approved
NicergolineThe metabolism of Nicergoline can be decreased when combined with Venlafaxine.Approved
NicotineThe metabolism of Nicotine can be decreased when combined with Venlafaxine.Approved
NifedipineThe metabolism of Nifedipine can be decreased when combined with Venlafaxine.Approved
NilotinibVenlafaxine may increase the QTc-prolonging activities of Nilotinib.Approved, Investigational
NilvadipineThe metabolism of Nilvadipine can be decreased when combined with Venlafaxine.Approved
NimodipineThe serum concentration of Nimodipine can be increased when it is combined with Venlafaxine.Approved
NintedanibThe serum concentration of Nintedanib can be increased when it is combined with Venlafaxine.Approved
NisoldipineThe metabolism of Nisoldipine can be decreased when combined with Venlafaxine.Approved
NitrazepamThe metabolism of Nitrazepam can be decreased when combined with Venlafaxine.Approved
NitrendipineThe metabolism of Nitrendipine can be decreased when combined with Venlafaxine.Approved
NitrofuralThe metabolism of Nitrofural can be decreased when combined with Venlafaxine.Approved, Vet Approved
Nitrous oxideThe risk or severity of adverse effects can be increased when Nitrous oxide is combined with Venlafaxine.Approved, Vet Approved
NizatidineThe serum concentration of Nizatidine can be increased when it is combined with Venlafaxine.Approved
NorepinephrineVenlafaxine may increase the tachycardic activities of Norepinephrine.Approved
NorethisteroneThe metabolism of Norethisterone can be decreased when combined with Venlafaxine.Approved
NorgestrelThe metabolism of Norgestrel can be decreased when combined with Venlafaxine.Approved
NormethadoneNormethadone may increase the serotonergic activities of Venlafaxine.Approved, Illicit
NortriptylineThe risk or severity of adverse effects can be increased when Venlafaxine is combined with Nortriptyline.Approved
NylidrinVenlafaxine may increase the tachycardic activities of Nylidrin.Approved
OctamoxinOctamoxin may increase the serotonergic activities of Venlafaxine.Withdrawn
OctreotideVenlafaxine may increase the hypoglycemic activities of Octreotide.Approved, Investigational
OfloxacinVenlafaxine may increase the QTc-prolonging activities of Ofloxacin.Approved
OlanzapineVenlafaxine may increase the serotonergic activities of Olanzapine.Approved, Investigational
OlaparibThe serum concentration of Olaparib can be increased when it is combined with Venlafaxine.Approved
OlodaterolVenlafaxine may increase the tachycardic activities of Olodaterol.Approved
OlopatadineThe metabolism of Olopatadine can be decreased when combined with Venlafaxine.Approved
OmbitasvirThe serum concentration of Ombitasvir can be increased when it is combined with Venlafaxine.Approved
OmeprazoleThe metabolism of Omeprazole can be decreased when combined with Venlafaxine.Approved, Investigational, Vet Approved
OndansetronVenlafaxine may increase the QTc-prolonging activities of Ondansetron.Approved
OpiumOpium may increase the serotonergic activities of Venlafaxine.Approved, Illicit
OrciprenalineVenlafaxine may increase the tachycardic activities of Orciprenaline.Approved
OrphenadrineThe metabolism of Orphenadrine can be decreased when combined with Venlafaxine.Approved
OsanetantThe risk or severity of adverse effects can be increased when Venlafaxine is combined with Osanetant.Investigational
OsimertinibThe serum concentration of Venlafaxine can be increased when it is combined with Osimertinib.Approved
OspemifeneThe metabolism of Ospemifene can be decreased when combined with Venlafaxine.Approved
OxazepamThe metabolism of Oxazepam can be decreased when combined with Venlafaxine.Approved
OxetacaineThe risk or severity of adverse effects can be increased when Oxetacaine is combined with Venlafaxine.Investigational
OxprenololThe serum concentration of Oxprenolol can be increased when it is combined with Venlafaxine.Approved
OxybuprocaineThe risk or severity of adverse effects can be increased when Oxybuprocaine is combined with Venlafaxine.Approved
OxybutyninThe metabolism of Oxybutynin can be decreased when combined with Venlafaxine.Approved, Investigational
OxycodoneThe risk or severity of adverse effects can be increased when Venlafaxine is combined with Oxycodone.Approved, Illicit, Investigational
OxymetazolineVenlafaxine may increase the tachycardic activities of Oxymetazoline.Approved
OxymorphoneThe metabolism of Oxymorphone can be decreased when combined with Venlafaxine.Approved, Investigational, Vet Approved
P-NitrophenolThe serum concentration of Venlafaxine can be increased when it is combined with P-Nitrophenol.Experimental
PaclitaxelThe metabolism of Paclitaxel can be decreased when combined with Venlafaxine.Approved, Vet Approved
PalbociclibThe serum concentration of Venlafaxine can be increased when it is combined with Palbociclib.Approved
PaliperidoneVenlafaxine may increase the QTc-prolonging activities of Paliperidone.Approved
Palmitic AcidThe serum concentration of Venlafaxine can be increased when it is combined with Palmitic Acid.Experimental
PalonosetronThe metabolism of Palonosetron can be decreased when combined with Venlafaxine.Approved, Investigational
PanobinostatThe serum concentration of Venlafaxine can be increased when it is combined with Panobinostat.Approved, Investigational
PantoprazoleThe metabolism of Pantoprazole can be decreased when combined with Venlafaxine.Approved
ParaldehydeThe risk or severity of adverse effects can be increased when Paraldehyde is combined with Venlafaxine.Approved
ParamethadioneThe metabolism of Paramethadione can be decreased when combined with Venlafaxine.Approved
ParamethasoneThe metabolism of Paramethasone can be decreased when combined with Venlafaxine.Approved
ParecoxibVenlafaxine may increase the antiplatelet activities of Parecoxib.Approved
PargylinePargyline may increase the serotonergic activities of Venlafaxine.Approved
ParicalcitolThe metabolism of Paricalcitol can be decreased when combined with Venlafaxine.Approved, Investigational
ParitaprevirThe metabolism of Paritaprevir can be decreased when combined with Venlafaxine.Approved
ParoxetineThe metabolism of Venlafaxine can be decreased when combined with Paroxetine.Approved, Investigational
PasireotideVenlafaxine may increase the hypoglycemic activities of Pasireotide.Approved
PazopanibThe serum concentration of Pazopanib can be increased when it is combined with Venlafaxine.Approved
Peginterferon alfa-2bThe serum concentration of Venlafaxine can be decreased when it is combined with Peginterferon alfa-2b.Approved
PenbutololThe serum concentration of Penbutolol can be increased when it is combined with Venlafaxine.Approved, Investigational
PentamidineVenlafaxine may increase the QTc-prolonging activities of Pentamidine.Approved
PentazocinePentazocine may increase the serotonergic activities of Venlafaxine.Approved, Vet Approved
PentobarbitalThe metabolism of Venlafaxine can be increased when combined with Pentobarbital.Approved, Vet Approved
PerampanelThe metabolism of Perampanel can be decreased when combined with Venlafaxine.Approved
PerazineThe risk or severity of adverse effects can be increased when Venlafaxine is combined with Perazine.Investigational
PerflutrenVenlafaxine may increase the QTc-prolonging activities of Perflutren.Approved
PergolideThe metabolism of Pergolide can be decreased when combined with Venlafaxine.Approved, Vet Approved, Withdrawn
PerhexilineThe metabolism of Perhexiline can be decreased when combined with Venlafaxine.Approved
PerindoprilThe serum concentration of Venlafaxine can be increased when it is combined with Perindopril.Approved
PermethrinThe metabolism of Permethrin can be decreased when combined with Venlafaxine.Approved, Investigational
PerospironeThe risk or severity of adverse effects can be increased when Venlafaxine is combined with Perospirone.Approved
PerphenazineThe metabolism of Perphenazine can be decreased when combined with Venlafaxine.Approved
PethidineThe risk or severity of adverse effects can be increased when Venlafaxine is combined with Pethidine.Approved
PhenacetinThe metabolism of Phenacetin can be decreased when combined with Venlafaxine.Withdrawn
PhenelzinePhenelzine may increase the serotonergic activities of Venlafaxine.Approved
PhenforminThe metabolism of Phenformin can be decreased when combined with Venlafaxine.Approved, Withdrawn
PhenindioneThe risk or severity of adverse effects can be increased when Venlafaxine is combined with Phenindione.Approved
PheniprazinePheniprazine may increase the serotonergic activities of Venlafaxine.Withdrawn
PhenobarbitalThe metabolism of Venlafaxine can be increased when combined with Phenobarbital.Approved
PhenoxybenzamineThe metabolism of Phenoxybenzamine can be decreased when combined with Venlafaxine.Approved
PhenoxyethanolThe risk or severity of adverse effects can be increased when Phenoxyethanol is combined with Venlafaxine.Approved
PhenoxypropazinePhenoxypropazine may increase the serotonergic activities of Venlafaxine.Withdrawn
PhenprocoumonThe risk or severity of adverse effects can be increased when Venlafaxine is combined with Phenprocoumon.Approved
PhenylephrineVenlafaxine may increase the tachycardic activities of Phenylephrine.Approved
PhenylpropanolamineVenlafaxine may increase the tachycardic activities of Phenylpropanolamine.Approved, Vet Approved, Withdrawn
PhenytoinThe metabolism of Venlafaxine can be increased when combined with Phenytoin.Approved, Vet Approved
PilocarpineThe metabolism of Pilocarpine can be decreased when combined with Venlafaxine.Approved
PimecrolimusThe metabolism of Pimecrolimus can be decreased when combined with Venlafaxine.Approved, Investigational
PimozideThe serum concentration of Pimozide can be increased when it is combined with Venlafaxine.Approved
PinacidilThe metabolism of Pinacidil can be decreased when combined with Venlafaxine.Withdrawn
PindololThe metabolism of Pindolol can be decreased when combined with Venlafaxine.Approved
PioglitazoneThe metabolism of Pioglitazone can be decreased when combined with Venlafaxine.Approved, Investigational
PipamperoneThe risk or severity of adverse effects can be increased when Venlafaxine is combined with Pipamperone.Approved
PiperazineThe metabolism of Piperazine can be decreased when combined with Venlafaxine.Approved, Vet Approved
PipotiazineThe metabolism of Pipotiazine can be decreased when combined with Venlafaxine.Approved
PirbuterolVenlafaxine may increase the tachycardic activities of Pirbuterol.Approved
PiritramidePiritramide may increase the serotonergic activities of Venlafaxine.Investigational
PirlindolePirlindole may increase the serotonergic activities of Venlafaxine.Approved
PitavastatinThe serum concentration of Pitavastatin can be increased when it is combined with Venlafaxine.Approved
PivhydrazinePivhydrazine may increase the serotonergic activities of Venlafaxine.Withdrawn
PizotifenThe risk or severity of adverse effects can be increased when Pizotifen is combined with Venlafaxine.Approved
Platelet Activating FactorThe serum concentration of Venlafaxine can be decreased when it is combined with Platelet Activating Factor.Experimental
PodofiloxThe metabolism of Podofilox can be decreased when combined with Venlafaxine.Approved
PolythiazideVenlafaxine may increase the hyponatremic activities of Polythiazide.Approved
PomalidomideThe metabolism of Pomalidomide can be decreased when combined with Venlafaxine.Approved
PonatinibThe metabolism of Ponatinib can be decreased when combined with Venlafaxine.Approved
PosaconazoleThe metabolism of Venlafaxine can be decreased when combined with Posaconazole.Approved, Investigational, Vet Approved
PractololThe serum concentration of Practolol can be increased when it is combined with Venlafaxine.Approved
PramlintideVenlafaxine may increase the hypoglycemic activities of Pramlintide.Approved, Investigational
PramocaineThe risk or severity of adverse effects can be increased when Pramocaine is combined with Venlafaxine.Approved
PrasteroneThe metabolism of Prasterone can be decreased when combined with Venlafaxine.Approved, Nutraceutical
PrasugrelThe metabolism of Prasugrel can be decreased when combined with Venlafaxine.Approved
PravastatinThe metabolism of Pravastatin can be decreased when combined with Venlafaxine.Approved
PrazepamThe metabolism of Prazepam can be decreased when combined with Venlafaxine.Approved, Illicit
PraziquantelThe metabolism of Praziquantel can be decreased when combined with Venlafaxine.Approved, Vet Approved
PrazosinThe serum concentration of Venlafaxine can be increased when it is combined with Prazosin.Approved
PrednisoloneThe metabolism of Prednisolone can be decreased when combined with Venlafaxine.Approved, Vet Approved
PrednisoneThe metabolism of Prednisone can be decreased when combined with Venlafaxine.Approved, Vet Approved
PregabalinThe risk or severity of adverse effects can be increased when Pregabalin is combined with Venlafaxine.Approved, Illicit, Investigational
PregnanoloneThe risk or severity of adverse effects can be increased when Pregnanolone is combined with Venlafaxine.Investigational
PrilocaineThe risk or severity of adverse effects can be increased when Prilocaine is combined with Venlafaxine.Approved
PrimaquineVenlafaxine may increase the QTc-prolonging activities of Primaquine.Approved
PrimidoneThe metabolism of Venlafaxine can be increased when combined with Primidone.Approved, Vet Approved
ProbenecidThe serum concentration of Venlafaxine can be increased when it is combined with Probenecid.Approved
ProcainamideVenlafaxine may increase the QTc-prolonging activities of Procainamide.Approved
ProcaineThe risk or severity of adverse effects can be increased when Procaine is combined with Venlafaxine.Approved, Investigational, Vet Approved
ProcarbazineThe risk or severity of adverse effects can be increased when Venlafaxine is combined with Procarbazine.Approved
ProcaterolVenlafaxine may increase the tachycardic activities of Procaterol.Approved
ProchlorperazineThe metabolism of Prochlorperazine can be decreased when combined with Venlafaxine.Approved, Vet Approved
ProgesteroneThe metabolism of Progesterone can be decreased when combined with Venlafaxine.Approved, Vet Approved
ProguanilThe metabolism of Proguanil can be decreased when combined with Venlafaxine.Approved
PromazineVenlafaxine may increase the QTc-prolonging activities of Promazine.Approved, Vet Approved
PromethazineThe risk or severity of adverse effects can be increased when Venlafaxine is combined with Promethazine.Approved
PropafenoneThe serum concentration of Venlafaxine can be increased when it is combined with Propafenone.Approved
ProparacaineThe risk or severity of adverse effects can be increased when Proparacaine is combined with Venlafaxine.Approved, Vet Approved
PropericiazineThe risk or severity of adverse effects can be increased when Venlafaxine is combined with Propericiazine.Approved
PropofolThe metabolism of Propofol can be decreased when combined with Venlafaxine.Approved, Investigational, Vet Approved
PropoxycaineThe risk or severity of adverse effects can be increased when Propoxycaine is combined with Venlafaxine.Approved
PropranololThe metabolism of Propranolol can be decreased when combined with Venlafaxine.Approved, Investigational
ProthipendylThe risk or severity of adverse effects can be increased when Venlafaxine is combined with Prothipendyl.Investigational
ProtriptylineThe risk or severity of adverse effects can be increased when Venlafaxine is combined with Protriptyline.Approved
PrucaloprideThe serum concentration of Prucalopride can be increased when it is combined with Venlafaxine.Approved
PSD502The risk or severity of adverse effects can be increased when PSD502 is combined with Venlafaxine.Investigational
PseudoephedrineVenlafaxine may increase the tachycardic activities of Pseudoephedrine.Approved
PyrazinamideThe metabolism of Pyrazinamide can be decreased when combined with Venlafaxine.Approved
PyrimethamineThe metabolism of Venlafaxine can be decreased when combined with Pyrimethamine.Approved, Vet Approved
QuazepamThe metabolism of Quazepam can be decreased when combined with Venlafaxine.Approved, Illicit
QuercetinThe serum concentration of Venlafaxine can be increased when it is combined with Quercetin.Experimental
QuetiapineVenlafaxine may increase the QTc-prolonging activities of Quetiapine.Approved
QuinacrineThe metabolism of Quinacrine can be decreased when combined with Venlafaxine.Approved
QuinethazoneVenlafaxine may increase the hyponatremic activities of Quinethazone.Approved
QuinidineVenlafaxine may increase the QTc-prolonging activities of Quinidine.Approved
QuinineVenlafaxine may increase the QTc-prolonging activities of Quinine.Approved
RabeprazoleThe metabolism of Rabeprazole can be decreased when combined with Venlafaxine.Approved, Investigational
RacepinephrineVenlafaxine may increase the tachycardic activities of Racepinephrine.Approved
RacloprideThe risk or severity of adverse effects can be increased when Venlafaxine is combined with Raclopride.Investigational
RactopamineVenlafaxine may increase the tachycardic activities of Ractopamine.Vet Approved
RaloxifeneThe metabolism of Raloxifene can be decreased when combined with Venlafaxine.Approved, Investigational
RamelteonThe metabolism of Ramelteon can be decreased when combined with Venlafaxine.Approved, Investigational
RanitidineThe serum concentration of Venlafaxine can be increased when it is combined with Ranitidine.Approved
RanolazineThe serum concentration of Ranolazine can be increased when it is combined with Venlafaxine.Approved, Investigational
RasagilineRasagiline may increase the serotonergic activities of Venlafaxine.Approved
ReboxetineThe metabolism of Reboxetine can be decreased when combined with Venlafaxine.Approved, Investigational
RegorafenibThe metabolism of Regorafenib can be decreased when combined with Venlafaxine.Approved
RemifentanilRemifentanil may increase the serotonergic activities of Venlafaxine.Approved
RemoxiprideThe metabolism of Remoxipride can be decreased when combined with Venlafaxine.Approved, Withdrawn
RepaglinideThe metabolism of Repaglinide can be decreased when combined with Venlafaxine.Approved, Investigational
repinotanThe metabolism of repinotan can be decreased when combined with Venlafaxine.Investigational
ReserpineThe serum concentration of Venlafaxine can be decreased when it is combined with Reserpine.Approved
RetapamulinThe metabolism of Retapamulin can be decreased when combined with Venlafaxine.Approved
RifabutinThe metabolism of Venlafaxine can be increased when combined with Rifabutin.Approved
RifampicinThe metabolism of Venlafaxine can be increased when combined with Rifampicin.Approved
RifapentineThe metabolism of Venlafaxine can be increased when combined with Rifapentine.Approved
RifaximinThe serum concentration of Rifaximin can be increased when it is combined with Venlafaxine.Approved, Investigational
RilmenidineVenlafaxine may increase the tachycardic activities of Rilmenidine.Investigational
RilpivirineThe metabolism of Rilpivirine can be decreased when combined with Venlafaxine.Approved
RimonabantThe metabolism of Rimonabant can be decreased when combined with Venlafaxine.Approved, Investigational
RiociguatThe metabolism of Riociguat can be decreased when combined with Venlafaxine.Approved
RisperidoneThe metabolism of Risperidone can be decreased when combined with Venlafaxine.Approved, Investigational
RitanserinThe risk or severity of adverse effects can be increased when Venlafaxine is combined with Ritanserin.Investigational
RitobegronVenlafaxine may increase the tachycardic activities of Ritobegron.Investigational
RitodrineVenlafaxine may increase the tachycardic activities of Ritodrine.Approved
RitonavirThe metabolism of Venlafaxine can be decreased when combined with Ritonavir.Approved, Investigational
RivaroxabanThe metabolism of Rivaroxaban can be decreased when combined with Venlafaxine.Approved
RizatriptanThe risk or severity of adverse effects can be increased when Venlafaxine is combined with Rizatriptan.Approved
RofecoxibVenlafaxine may increase the antiplatelet activities of Rofecoxib.Investigational, Withdrawn
RolapitantThe metabolism of Rolapitant can be decreased when combined with Venlafaxine.Approved
RomidepsinThe metabolism of Romidepsin can be decreased when combined with Venlafaxine.Approved, Investigational
RomifidineVenlafaxine may increase the tachycardic activities of Romifidine.Vet Approved
RopiniroleThe metabolism of Ropinirole can be decreased when combined with Venlafaxine.Approved, Investigational
RopivacaineThe metabolism of Ropivacaine can be decreased when combined with Venlafaxine.Approved
RosiglitazoneVenlafaxine may increase the hypoglycemic activities of Rosiglitazone.Approved, Investigational
RosuvastatinThe metabolism of Rosuvastatin can be decreased when combined with Venlafaxine.Approved
RotigotineThe metabolism of Rotigotine can be decreased when combined with Venlafaxine.Approved
RoxithromycinThe metabolism of Roxithromycin can be decreased when combined with Venlafaxine.Approved, Withdrawn
RuxolitinibThe metabolism of Ruxolitinib can be decreased when combined with Venlafaxine.Approved
S-EthylisothioureaThe risk or severity of adverse effects can be increased when S-Ethylisothiourea is combined with Venlafaxine.Experimental
SafrazineSafrazine may increase the serotonergic activities of Venlafaxine.Withdrawn
Sage 547The risk or severity of adverse effects can be increased when Sage 547 is combined with Venlafaxine.Investigational
SalbutamolVenlafaxine may increase the tachycardic activities of Salbutamol.Approved, Vet Approved
Salicylic acidThe serum concentration of Salicylic acid can be increased when it is combined with Venlafaxine.Approved, Vet Approved
SalmeterolThe serum concentration of Salmeterol can be increased when it is combined with Venlafaxine.Approved
SaquinavirThe metabolism of Venlafaxine can be decreased when combined with Saquinavir.Approved, Investigational
SaxagliptinThe serum concentration of Saxagliptin can be increased when it is combined with Venlafaxine.Approved
ScopolamineThe serum concentration of Venlafaxine can be increased when it is combined with Scopolamine.Approved
SecobarbitalThe metabolism of Venlafaxine can be increased when combined with Secobarbital.Approved, Vet Approved
SelegilineSelegiline may increase the serotonergic activities of Venlafaxine.Approved, Investigational, Vet Approved
SelexipagThe metabolism of Selexipag can be decreased when combined with Venlafaxine.Approved
SeratrodastThe metabolism of Seratrodast can be decreased when combined with Venlafaxine.Approved, Investigational
SertindoleThe metabolism of Sertindole can be decreased when combined with Venlafaxine.Approved, Withdrawn
SertralineThe risk or severity of adverse effects can be increased when Venlafaxine is combined with Sertraline.Approved
SevofluraneThe metabolism of Sevoflurane can be decreased when combined with Venlafaxine.Approved, Vet Approved
SibutramineThe metabolism of Sibutramine can be decreased when combined with Venlafaxine.Approved, Illicit, Investigational, Withdrawn
SildenafilThe metabolism of Venlafaxine can be decreased when combined with Sildenafil.Approved, Investigational
SilodosinThe serum concentration of Silodosin can be increased when it is combined with Venlafaxine.Approved
SiltuximabThe serum concentration of Venlafaxine can be decreased when it is combined with Siltuximab.Approved
SimeprevirThe serum concentration of Simeprevir can be increased when it is combined with Venlafaxine.Approved
SimvastatinThe metabolism of Simvastatin can be decreased when combined with Venlafaxine.Approved
SirolimusThe metabolism of Sirolimus can be decreased when combined with Venlafaxine.Approved, Investigational
SitagliptinThe metabolism of Sitagliptin can be decreased when combined with Venlafaxine.Approved, Investigational
Sodium oxybateThe risk or severity of adverse effects can be increased when Sodium oxybate is combined with Venlafaxine.Approved
SofosbuvirThe serum concentration of Sofosbuvir can be increased when it is combined with Venlafaxine.Approved
SolabegronVenlafaxine may increase the tachycardic activities of Solabegron.Investigational
SolifenacinThe metabolism of Solifenacin can be decreased when combined with Venlafaxine.Approved
SonidegibThe serum concentration of Sonidegib can be increased when it is combined with Venlafaxine.Approved, Investigational
SorafenibThe metabolism of Sorafenib can be decreased when combined with Venlafaxine.Approved, Investigational
SotalolVenlafaxine may increase the QTc-prolonging activities of Sotalol.Approved
SparfloxacinThe serum concentration of Sparfloxacin can be increased when it is combined with Venlafaxine.Approved
SparteineThe metabolism of Sparteine can be decreased when combined with Venlafaxine.Experimental
SphingosineThe serum concentration of Sphingosine can be increased when it is combined with Venlafaxine.Experimental
SpiramycinThe metabolism of Spiramycin can be decreased when combined with Venlafaxine.Approved
SpironolactoneThe serum concentration of Venlafaxine can be increased when it is combined with Spironolactone.Approved
SR 58611Venlafaxine may increase the tachycardic activities of SR 58611.Investigational
St. John's WortThe serum concentration of Venlafaxine can be decreased when it is combined with St. John's Wort.Nutraceutical
StaurosporineThe serum concentration of Venlafaxine can be increased when it is combined with Staurosporine.Experimental
StiripentolThe serum concentration of Venlafaxine can be increased when it is combined with Stiripentol.Approved
StreptozocinThe serum concentration of Venlafaxine can be decreased when it is combined with Streptozocin.Approved
SufentanilThe metabolism of Sufentanil can be decreased when combined with Venlafaxine.Approved, Investigational
SulfadiazineThe metabolism of Venlafaxine can be decreased when combined with Sulfadiazine.Approved, Vet Approved
SulfamethoxazoleThe metabolism of Sulfamethoxazole can be decreased when combined with Venlafaxine.Approved
SulfinpyrazoneThe metabolism of Sulfinpyrazone can be decreased when combined with Venlafaxine.Approved
SulfisoxazoleThe metabolism of Venlafaxine can be decreased when combined with Sulfisoxazole.Approved, Vet Approved
SulpirideThe risk or severity of adverse effects can be increased when Venlafaxine is combined with Sulpiride.Approved
SumatriptanThe risk or severity of adverse effects can be increased when Venlafaxine is combined with Sumatriptan.Approved, Investigational
SunitinibThe metabolism of Sunitinib can be decreased when combined with Venlafaxine.Approved, Investigational
SuvorexantThe serum concentration of Suvorexant can be increased when it is combined with Venlafaxine.Approved
SynephrineVenlafaxine may increase the tachycardic activities of Synephrine.Experimental
Synthetic Conjugated Estrogens, AThe metabolism of Synthetic Conjugated Estrogens, A can be decreased when combined with Venlafaxine.Approved
Synthetic Conjugated Estrogens, BThe metabolism of Synthetic Conjugated Estrogens, B can be decreased when combined with Venlafaxine.Approved
TacrineThe serum concentration of Venlafaxine can be increased when it is combined with Tacrine.Withdrawn
TacrolimusThe metabolism of Tacrolimus can be decreased when combined with Venlafaxine.Approved, Investigational
TadalafilThe metabolism of Tadalafil can be decreased when combined with Venlafaxine.Approved, Investigational
TamoxifenThe serum concentration of the active metabolites of Tamoxifen can be reduced when Tamoxifen is used in combination with Venlafaxine resulting in a loss in efficacy.Approved
TamsulosinThe metabolism of Tamsulosin can be decreased when combined with Venlafaxine.Approved, Investigational
TandospironeThe risk or severity of adverse effects can be increased when Tandospirone is combined with Venlafaxine.Investigational
TapentadolThe risk or severity of adverse effects can be increased when Venlafaxine is combined with Tapentadol.Approved
TasimelteonThe risk or severity of adverse effects can be increased when Tasimelteon is combined with Venlafaxine.Approved
TasosartanThe metabolism of Tasosartan can be decreased when combined with Venlafaxine.Approved
Taurochenodeoxycholic acidThe metabolism of Taurochenodeoxycholic acid can be decreased when combined with Venlafaxine.Experimental
Taurocholic AcidThe serum concentration of Taurocholic Acid can be increased when it is combined with Venlafaxine.Experimental
Technetium Tc-99m sestamibiThe serum concentration of Technetium Tc-99m sestamibi can be increased when it is combined with Venlafaxine.Approved
Tedizolid PhosphateTedizolid Phosphate may increase the serotonergic activities of Venlafaxine.Approved
TegaserodThe metabolism of Tegaserod can be decreased when combined with Venlafaxine.Investigational, Withdrawn
TelaprevirThe metabolism of Venlafaxine can be decreased when combined with Telaprevir.Approved
TelavancinVenlafaxine may increase the QTc-prolonging activities of Telavancin.Approved
TelithromycinThe metabolism of Venlafaxine can be decreased when combined with Telithromycin.Approved
TelmisartanThe serum concentration of Venlafaxine can be increased when it is combined with Telmisartan.Approved, Investigational
TemazepamThe metabolism of Temazepam can be decreased when combined with Venlafaxine.Approved
TemsirolimusThe metabolism of Temsirolimus can be decreased when combined with Venlafaxine.Approved
TeniposideThe metabolism of Teniposide can be decreased when combined with Venlafaxine.Approved
TerazosinThe serum concentration of Venlafaxine can be increased when it is combined with Terazosin.Approved
TerbinafineThe metabolism of Venlafaxine can be decreased when combined with Terbinafine.Approved, Investigational, Vet Approved
TerbutalineVenlafaxine may increase the tachycardic activities of Terbutaline.Approved
TerfenadineThe metabolism of Terfenadine can be decreased when combined with Venlafaxine.Withdrawn
TesmilifeneThe metabolism of Tesmilifene can be decreased when combined with Venlafaxine.Investigational
TestosteroneThe metabolism of Testosterone can be decreased when combined with Venlafaxine.Approved, Investigational
TetrabenazineVenlafaxine may increase the QTc-prolonging activities of Tetrabenazine.Approved
TetracaineThe risk or severity of adverse effects can be increased when Tetracaine is combined with Venlafaxine.Approved, Vet Approved
TetracyclineThe metabolism of Tetracycline can be decreased when combined with Venlafaxine.Approved, Vet Approved
TetrodotoxinThe risk or severity of adverse effects can be increased when Tetrodotoxin is combined with Venlafaxine.Investigational
ThalidomideThe risk or severity of adverse effects can be increased when Thalidomide is combined with Venlafaxine.Approved, Investigational, Withdrawn
TheophyllineThe metabolism of Theophylline can be decreased when combined with Venlafaxine.Approved
ThiamylalThe risk or severity of adverse effects can be increased when Thiamylal is combined with Venlafaxine.Approved, Vet Approved
ThiopentalThe risk or severity of adverse effects can be increased when Thiopental is combined with Venlafaxine.Approved, Vet Approved
ThioproperazineThe risk or severity of adverse effects can be increased when Venlafaxine is combined with Thioproperazine.Approved
ThioridazineThe serum concentration of Thioridazine can be increased when it is combined with Venlafaxine.Approved
ThiotepaThe metabolism of Thiotepa can be decreased when combined with Venlafaxine.Approved
ThiothixeneThe risk or severity of adverse effects can be increased when Venlafaxine is combined with Thiothixene.Approved
Thyroid, porcineThe therapeutic efficacy of Thyroid, porcine can be decreased when used in combination with Venlafaxine.Approved
TiagabineThe metabolism of Tiagabine can be decreased when combined with Venlafaxine.Approved
TiaprideThe risk or severity of adverse effects can be increased when Venlafaxine is combined with Tiapride.Investigational
TicagrelorThe metabolism of Ticagrelor can be decreased when combined with Venlafaxine.Approved
TiclopidineThe metabolism of Venlafaxine can be decreased when combined with Ticlopidine.Approved
TiletamineThe risk or severity of adverse effects can be increased when Tiletamine is combined with Venlafaxine.Vet Approved
TimololThe serum concentration of Timolol can be increased when it is combined with Venlafaxine.Approved
TinidazoleThe metabolism of Tinidazole can be decreased when combined with Venlafaxine.Approved, Investigational
TiotropiumThe metabolism of Tiotropium can be decreased when combined with Venlafaxine.Approved
TipranavirThe metabolism of Venlafaxine can be decreased when combined with Tipranavir.Approved, Investigational
TizanidineVenlafaxine may increase the tachycardic activities of Tizanidine.Approved
TocilizumabThe serum concentration of Venlafaxine can be decreased when it is combined with Tocilizumab.Approved
TofacitinibThe metabolism of Tofacitinib can be decreased when combined with Venlafaxine.Approved, Investigational
TolazamideVenlafaxine may increase the hypoglycemic activities of Tolazamide.Approved
TolbutamideThe metabolism of Venlafaxine can be decreased when combined with Tolbutamide.Approved
TolcaponeThe risk or severity of adverse effects can be increased when Tolcapone is combined with Venlafaxine.Approved, Withdrawn
ToloxatoneToloxatone may increase the serotonergic activities of Venlafaxine.Approved
TolterodineThe metabolism of Tolterodine can be decreased when combined with Venlafaxine.Approved, Investigational
TolvaptanThe serum concentration of Tolvaptan can be increased when it is combined with Venlafaxine.Approved
TopiramateThe metabolism of Venlafaxine can be decreased when combined with Topiramate.Approved
TopotecanThe serum concentration of Topotecan can be increased when it is combined with Venlafaxine.Approved, Investigational
ToremifeneVenlafaxine may increase the QTc-prolonging activities of Toremifene.Approved, Investigational
TrabectedinThe serum concentration of Trabectedin can be increased when it is combined with Venlafaxine.Approved, Investigational
TramadolVenlafaxine may increase the neuroexcitatory activities of Tramadol.Approved, Investigational
Trans-2-PhenylcyclopropylamineTrans-2-Phenylcyclopropylamine may increase the serotonergic activities of Venlafaxine.Experimental
TranylcypromineTranylcypromine may increase the serotonergic activities of Venlafaxine.Approved
Trastuzumab emtansineThe metabolism of Trastuzumab emtansine can be decreased when combined with Venlafaxine.Approved
TrazodoneVenlafaxine may increase the serotonergic activities of Trazodone.Approved, Investigational
TretinoinThe metabolism of Tretinoin can be decreased when combined with Venlafaxine.Approved, Investigational, Nutraceutical
TriamcinoloneThe metabolism of Triamcinolone can be decreased when combined with Venlafaxine.Approved, Vet Approved
TriazolamThe metabolism of Triazolam can be decreased when combined with Venlafaxine.Approved
TrichlormethiazideVenlafaxine may increase the hyponatremic activities of Trichlormethiazide.Approved, Vet Approved
TrifluoperazineThe serum concentration of Venlafaxine can be increased when it is combined with Trifluoperazine.Approved
TriflupromazineThe serum concentration of Venlafaxine can be increased when it is combined with Triflupromazine.Approved, Vet Approved
TrimethadioneThe metabolism of Trimethadione can be decreased when combined with Venlafaxine.Approved
TrimethoprimThe metabolism of Trimethoprim can be decreased when combined with Venlafaxine.Approved, Vet Approved
TrimipramineThe risk or severity of adverse effects can be increased when Venlafaxine is combined with Trimipramine.Approved
TriprolidineThe risk or severity of adverse effects can be increased when Triprolidine is combined with Venlafaxine.Approved
TroglitazoneThe metabolism of Troglitazone can be decreased when combined with Venlafaxine.Withdrawn
TroleandomycinThe metabolism of Troleandomycin can be decreased when combined with Venlafaxine.Approved
TropisetronTropisetron may increase the serotonergic activities of Venlafaxine.Investigational
TulobuterolVenlafaxine may increase the tachycardic activities of Tulobuterol.Investigational
Uc1010The risk or severity of adverse effects can be increased when Uc1010 is combined with Venlafaxine.Investigational
UdenafilThe metabolism of Udenafil can be decreased when combined with Venlafaxine.Approved, Investigational
UlipristalThe serum concentration of Ulipristal can be increased when it is combined with Venlafaxine.Approved
UmeclidiniumThe serum concentration of Umeclidinium can be increased when it is combined with Venlafaxine.Approved
ValdecoxibVenlafaxine may increase the antiplatelet activities of Valdecoxib.Investigational, Withdrawn
Valproic AcidThe metabolism of Venlafaxine can be decreased when combined with Valproic Acid.Approved, Investigational
ValsartanThe metabolism of Venlafaxine can be decreased when combined with Valsartan.Approved, Investigational
VandetanibVenlafaxine may increase the QTc-prolonging activities of Vandetanib.Approved
VanoxerineThe metabolism of Vanoxerine can be decreased when combined with Venlafaxine.Investigational
VardenafilThe metabolism of Vardenafil can be decreased when combined with Venlafaxine.Approved
VecuroniumThe serum concentration of Vecuronium can be increased when it is combined with Venlafaxine.Approved
VemurafenibVenlafaxine may increase the QTc-prolonging activities of Vemurafenib.Approved
VenetoclaxThe metabolism of Venetoclax can be decreased when combined with Venlafaxine.Approved
VerapamilThe metabolism of Verapamil can be decreased when combined with Venlafaxine.Approved
VicrivirocThe metabolism of Vicriviroc can be decreased when combined with Venlafaxine.Investigational
VigabatrinThe risk or severity of adverse effects can be increased when Vigabatrin is combined with Venlafaxine.Approved
VilanterolThe metabolism of Vilanterol can be decreased when combined with Venlafaxine.Approved
VilazodoneThe serum concentration of Vilazodone can be increased when it is combined with Venlafaxine.Approved
VinblastineThe metabolism of Vinblastine can be decreased when combined with Venlafaxine.Approved
VincristineThe serum concentration of Vincristine can be increased when it is combined with Venlafaxine.Approved, Investigational
VincristineThe metabolism of Vincristine can be decreased when combined with Venlafaxine.Approved, Investigational
VindesineThe serum concentration of Vindesine can be increased when it is combined with Venlafaxine.Approved
VinorelbineThe metabolism of Vinorelbine can be decreased when combined with Venlafaxine.Approved, Investigational
VismodegibThe metabolism of Vismodegib can be decreased when combined with Venlafaxine.Approved
VoriconazoleThe risk or severity of adverse effects can be increased when Voriconazole is combined with Venlafaxine.Approved, Investigational
VortioxetineThe risk or severity of adverse effects can be increased when Venlafaxine is combined with Vortioxetine.Approved
WarfarinThe risk or severity of adverse effects can be increased when Venlafaxine is combined with Warfarin.Approved
XylazineVenlafaxine may increase the tachycardic activities of Xylazine.Vet Approved
XylometazolineVenlafaxine may decrease the antihypertensive activities of Xylometazoline.Approved
YM-178Venlafaxine may increase the tachycardic activities of YM-178.Investigational
YohimbineThe metabolism of Yohimbine can be decreased when combined with Venlafaxine.Approved, Vet Approved
ZafirlukastThe metabolism of Zafirlukast can be decreased when combined with Venlafaxine.Approved, Investigational
ZalcitabineThe metabolism of Zalcitabine can be decreased when combined with Venlafaxine.Approved
ZaleplonThe metabolism of Zaleplon can be decreased when combined with Venlafaxine.Approved, Illicit, Investigational
ZiconotideThe risk or severity of adverse effects can be increased when Ziconotide is combined with Venlafaxine.Approved
ZidovudineThe metabolism of Zidovudine can be decreased when combined with Venlafaxine.Approved
ZileutonThe metabolism of Zileuton can be decreased when combined with Venlafaxine.Approved, Investigational, Withdrawn
ZimelidineVenlafaxine may increase the serotonergic activities of Zimelidine.Withdrawn
ZiprasidoneVenlafaxine may increase the QTc-prolonging activities of Ziprasidone.Approved
ZolazepamThe risk or severity of adverse effects can be increased when Zolazepam is combined with Venlafaxine.Vet Approved
ZolmitriptanThe risk or severity of adverse effects can be increased when Venlafaxine is combined with Zolmitriptan.Approved, Investigational
ZolpidemThe metabolism of Zolpidem can be decreased when combined with Venlafaxine.Approved
ZomepiracThe metabolism of Zomepirac can be decreased when combined with Venlafaxine.Withdrawn
ZonisamideThe metabolism of Zonisamide can be decreased when combined with Venlafaxine.Approved, Investigational
ZopicloneThe serum concentration of Zopiclone can be increased when it is combined with Venlafaxine.Approved
ZotepineThe risk or severity of adverse effects can be increased when Venlafaxine is combined with Zotepine.Approved
ZuclopenthixolThe serum concentration of Zuclopenthixol can be increased when it is combined with Venlafaxine.Approved, Investigational
Food Interactions
  • Avoid alcohol.
  • Avoid St.John's Wort.
  • Take with food.
References
Synthesis Reference

Thomas P. Jerussi, Chrisantha H. Senanayake, “Derivatives of (+)-venlafaxine and methods of preparing and using the same.” U.S. Patent US6197828, issued June, 1994.

US6197828
General References
  1. Golden RN, Nicholas L: Antidepressant efficacy of venlafaxine. Depress Anxiety. 2000;12 Suppl 1:45-9. [PubMed:11098413 ]
  2. Thase ME, Clayton AH, Haight BR, Thompson AH, Modell JG, Johnston JA: A double-blind comparison between bupropion XL and venlafaxine XR: sexual functioning, antidepressant efficacy, and tolerability. J Clin Psychopharmacol. 2006 Oct;26(5):482-8. [PubMed:16974189 ]
  3. Bielski RJ, Ventura D, Chang CC: A double-blind comparison of escitalopram and venlafaxine extended release in the treatment of major depressive disorder. J Clin Psychiatry. 2004 Sep;65(9):1190-6. [PubMed:15367045 ]
  4. Rowbotham MC, Goli V, Kunz NR, Lei D: Venlafaxine extended release in the treatment of painful diabetic neuropathy: a double-blind, placebo-controlled study. Pain. 2004 Aug;110(3):697-706. [PubMed:15288411 ]
  5. Ozyalcin SN, Talu GK, Kiziltan E, Yucel B, Ertas M, Disci R: The efficacy and safety of venlafaxine in the prophylaxis of migraine. Headache. 2005 Feb;45(2):144-52. [PubMed:15705120 ]
  6. Whirl-Carrillo M, McDonagh EM, Hebert JM, Gong L, Sangkuhl K, Thorn CF, Altman RB, Klein TE: Pharmacogenomics knowledge for personalized medicine. Clin Pharmacol Ther. 2012 Oct;92(4):414-7. doi: 10.1038/clpt.2012.96. [PubMed:22992668 ]
  7. Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. [PubMed:19515014 ]
External Links
ATC CodesN06AX16
AHFS Codes
  • 28:16.04.92
PDB EntriesNot Available
FDA labelDownload (3.38 MB)
MSDSDownload (36.5 KB)
ADMET
Predicted ADMET features
PropertyValueProbability
Human Intestinal Absorption+0.9782
Blood Brain Barrier+0.9382
Caco-2 permeable+0.852
P-glycoprotein substrateSubstrate0.6534
P-glycoprotein inhibitor IInhibitor0.7031
P-glycoprotein inhibitor IIInhibitor0.8031
Renal organic cation transporterNon-inhibitor0.5792
CYP450 2C9 substrateNon-substrate0.7583
CYP450 2D6 substrateSubstrate0.8919
CYP450 3A4 substrateSubstrate0.7407
CYP450 1A2 substrateNon-inhibitor0.7664
CYP450 2C9 inhibitorNon-inhibitor0.6876
CYP450 2D6 inhibitorInhibitor0.7287
CYP450 2C19 inhibitorNon-inhibitor0.7199
CYP450 3A4 inhibitorNon-inhibitor0.8308
CYP450 inhibitory promiscuityLow CYP Inhibitory Promiscuity0.8666
Ames testNon AMES toxic0.8
CarcinogenicityNon-carcinogens0.6762
BiodegradationNot ready biodegradable0.9941
Rat acute toxicity2.5404 LD50, mol/kg Not applicable
hERG inhibition (predictor I)Weak inhibitor0.5486
hERG inhibition (predictor II)Inhibitor0.6627
ADMET data is predicted using admetSAR, a free tool for evaluating chemical ADMET properties. (23092397 )
Pharmacoeconomics
Manufacturers
  • Wyeth pharmaceuticals inc
  • Teva pharmaceuticals usa inc
  • Osmotica pharmaceutical corp
  • Actavis totowa llc
  • Amneal pharmaceuticals
  • Aurobindo pharma ltd
  • Caraco pharmaceutical laboratories ltd
  • Dr reddys laboratories ltd
  • Mylan pharmaceuticals inc
  • Pliva hrvatska doo
  • Sandoz inc
  • Vintage pharmaceuticals llc
  • Zydus pharmaceuticals usa inc
  • Wyeth
Packagers
Dosage forms
FormRouteStrength
Capsule, extended releaseOral150.0 mg
Capsule, extended releaseOral75.0 mg
TabletOral37.5 mg
TabletOral50 mg
TabletOral75 mg
Capsule, extended releaseOral150 mg
Capsule, extended releaseOral150 mg/1
Capsule, extended releaseOral37.5 mg
Capsule, extended releaseOral37.5 mg/1
Capsule, extended releaseOral75 mg/1
Capsule, extended releaseOral75 mg
TabletOral37.5 mg/1
TabletOral75 mg/1
Capsule, coated, extended releaseOral75 mg/1
Capsule, delayed releaseOral75 mg/1
TabletOral100 mg/1
TabletOral25 mg/1
TabletOral50 mg/1
Tablet, extended releaseOral150 mg/1
Tablet, extended releaseOral225 mg/1
Tablet, extended releaseOral37.5 mg/1
Tablet, extended releaseOral75 mg/1
Tablet, film coated, extended releaseOral150 mg/1
Tablet, film coated, extended releaseOral225 mg/1
Tablet, film coated, extended releaseOral37.5 mg/1
Tablet, film coated, extended releaseOral75 mg/1
Prices
Unit descriptionCostUnit
Venlafaxine HCl 30 225 mg 24 Hour tablet Bottle276.98USD bottle
Effexor XR 30 37.5 mg 24 Hour Capsule Bottle144.33USD bottle
Venlafaxine HCl 30 37.5 mg 24 Hour tablet Bottle114.46USD bottle
Effexor 30 75 mg tablet Bottle87.83USD bottle
Effexor 30 25 mg tablet Bottle74.82USD bottle
Effexor XR 150 mg 24 Hour Capsule5.87USD capsule
Effexor xr 150 mg capsule5.65USD capsule
Effexor XR 75 mg 24 Hour Capsule5.39USD capsule
Effexor xr 75 mg capsule4.76USD capsule
Venlafaxine HCl 150 mg 24 Hour tablet4.72USD tablet
Effexor xr 37.5 mg capsule4.63USD capsule
Venlafaxine HCl 75 mg 24 Hour tablet4.42USD tablet
Effexor 100 mg tablet2.92USD tablet
Effexor 75 mg tablet2.7USD tablet
Effexor 50 mg tablet2.6USD tablet
Effexor 37.5 mg tablet2.5USD tablet
Effexor 25 mg tablet2.4USD tablet
Venlafaxine hcl 100 mg tablet2.36USD tablet
Venlafaxine hcl 75 mg tablet2.23USD tablet
Effexor Xr 150 mg Extended-Release Capsule2.16USD capsule
Venlafaxine hcl 50 mg tablet2.1USD tablet
Effexor Xr 75 mg Extended-Release Capsule2.05USD capsule
Venlafaxine hcl 37.5 mg tablet2.04USD tablet
Venlafaxine hcl 25 mg tablet1.98USD tablet
Apo-Venlafaxine Xr 150 mg Extended-Release Capsule1.2USD capsule
Co Venlafaxine Xr 150 mg Extended-Release Capsule1.2USD capsule
Mylan-Venlafaxine Xr 150 mg Extended-Release Capsule1.2USD capsule
Novo-Venlafaxine Xr 150 mg Extended-Release Capsule1.2USD capsule
Pms-Venlafaxine Xr 150 mg Extended-Release Capsule1.2USD capsule
Ratio-Venlafaxine Xr 150 mg Extended-Release Capsule1.2USD capsule
Sandoz Venlafaxine Xr 150 mg Extended-Release Capsule1.2USD capsule
Apo-Venlafaxine Xr 75 mg Extended-Release Capsule1.14USD capsule
Co Venlafaxine Xr 75 mg Extended-Release Capsule1.14USD capsule
Mylan-Venlafaxine Xr 75 mg Extended-Release Capsule1.14USD capsule
Novo-Venlafaxine Xr 75 mg Extended-Release Capsule1.14USD capsule
Pms-Venlafaxine Xr 75 mg Extended-Release Capsule1.14USD capsule
Ratio-Venlafaxine Xr 75 mg Extended-Release Capsule1.14USD capsule
Sandoz Venlafaxine Xr 75 mg Extended-Release Capsule1.14USD capsule
Effexor Xr 37.5 mg Extended-Release Capsule1.02USD capsule
Apo-Venlafaxine Xr 37.5 mg Extended-Release Capsule0.57USD capsule
Co Venlafaxine Xr 37.5 mg Extended-Release Capsule0.57USD capsule
Mylan-Venlafaxine Xr 37.5 mg Extended-Release Capsule0.57USD capsule
Novo-Venlafaxine Xr 37.5 mg Extended-Release Capsule0.57USD capsule
Pms-Venlafaxine Xr 37.5 mg Extended-Release Capsule0.57USD capsule
Ratio-Venlafaxine Xr 37.5 mg Extended-Release Capsule0.57USD capsule
Sandoz Venlafaxine Xr 37.5 mg Extended-Release Capsule0.57USD capsule
DrugBank does not sell nor buy drugs. Pricing information is supplied for informational purposes only.
Patents
Patent NumberPediatric ExtensionApprovedExpires (estimated)
CA2126305 No2006-10-172014-06-20Canada
CA2199778 No2005-12-202017-03-12Canada
US5916923 No1993-06-282013-06-28Us
US6274171 Yes1997-09-202017-09-20Us
US6403120 Yes1997-09-202017-09-20Us
US6419958 Yes1997-09-202017-09-20Us
Properties
StateSolid
Experimental Properties
PropertyValueSource
melting point215-217 °C (Hydrochloride salt)Not Available
water solubility572 mg/ml (Hydrochloride salt)Not Available
Predicted Properties
PropertyValueSource
Water Solubility0.23 mg/mLALOGPS
logP2.69ALOGPS
logP2.74ChemAxon
logS-3.1ALOGPS
pKa (Strongest Acidic)14.42ChemAxon
pKa (Strongest Basic)8.91ChemAxon
Physiological Charge1ChemAxon
Hydrogen Acceptor Count3ChemAxon
Hydrogen Donor Count1ChemAxon
Polar Surface Area32.7 Å2ChemAxon
Rotatable Bond Count5ChemAxon
Refractivity83.02 m3·mol-1ChemAxon
Polarizability32.33 Å3ChemAxon
Number of Rings2ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleYesChemAxon
Spectra
Mass Spec (NIST)Not Available
Spectra
Spectrum TypeDescriptionSplash Key
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, PositiveNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, PositiveNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, PositiveNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, NegativeNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, NegativeNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, NegativeNot Available
1D NMR1H NMR SpectrumNot Available
2D NMR[1H,13C] 2D NMR SpectrumNot Available
Taxonomy
DescriptionThis compound belongs to the class of organic compounds known as phenylpropylamines. These are compounds containing a phenylpropylamine moiety, which consists of a phenyl group substituted at the third carbon by an propan-1-amine.
KingdomOrganic compounds
Super ClassBenzenoids
ClassBenzene and substituted derivatives
Sub ClassPhenylpropylamines
Direct ParentPhenylpropylamines
Alternative Parents
Substituents
  • Phenylpropylamine
  • Methoxybenzene
  • Phenol ether
  • Anisole
  • Aralkylamine
  • Cyclohexanol
  • Alkyl aryl ether
  • Tertiary alcohol
  • Cyclic alcohol
  • 1,3-aminoalcohol
  • Tertiary aliphatic amine
  • Tertiary amine
  • Ether
  • Hydrocarbon derivative
  • Organooxygen compound
  • Organonitrogen compound
  • Amine
  • Alcohol
  • Aromatic homomonocyclic compound
Molecular FrameworkAromatic homomonocyclic compounds
External DescriptorsNot Available

Targets

Kind
Protein
Organism
Human
Pharmacological action
yes
Actions
inhibitor
General Function:
Serotonin:sodium symporter activity
Specific Function:
Serotonin transporter whose primary function in the central nervous system involves the regulation of serotonergic signaling via transport of serotonin molecules from the synaptic cleft back into the pre-synaptic terminal for re-utilization. Plays a key role in mediating regulation of the availability of serotonin to other receptors of serotonergic systems. Terminates the action of serotonin an...
Gene Name:
SLC6A4
Uniprot ID:
P31645
Molecular Weight:
70324.165 Da
References
  1. Chen F, Larsen MB, Sanchez C, Wiborg O: The S-enantiomer of R,S-citalopram, increases inhibitor binding to the human serotonin transporter by an allosteric mechanism. Comparison with other serotonin transporter inhibitors. Eur Neuropsychopharmacol. 2005 Mar;15(2):193-8. [PubMed:15695064 ]
  2. Gould GG, Altamirano AV, Javors MA, Frazer A: A comparison of the chronic treatment effects of venlafaxine and other antidepressants on serotonin and norepinephrine transporters. Biol Psychiatry. 2006 Mar 1;59(5):408-14. Epub 2005 Sep 2. [PubMed:16140280 ]
  3. Shang Y, Gibbs MA, Marek GJ, Stiger T, Burstein AH, Marek K, Seibyl JP, Rogers JF: Displacement of serotonin and dopamine transporters by venlafaxine extended release capsule at steady state: a [123I]2beta-carbomethoxy-3beta-(4-iodophenyl)-tropane single photon emission computed tomography imaging study. J Clin Psychopharmacol. 2007 Feb;27(1):71-5. [PubMed:17224717 ]
  4. Malizia AL, Melichar JM, Brown DJ, Gunn RN, Reynolds A, Jones T, Nutt DJ: Demonstration of clomipramine and venlafaxine occupation at serotonin reuptake sites in man in vivo. J Psychopharmacol. 1997;11(3):279-81. [PubMed:9305421 ]
  5. Tatsumi M, Groshan K, Blakely RD, Richelson E: Pharmacological profile of antidepressants and related compounds at human monoamine transporters. Eur J Pharmacol. 1997 Dec 11;340(2-3):249-58. [PubMed:9537821 ]
  6. Van Ameringen M, Mancini C, Patterson B, Simpson W: Pharmacotherapy for social anxiety disorder: an update. Isr J Psychiatry Relat Sci. 2009;46(1):53-61. [PubMed:19728573 ]
  7. Beique J, de Montigny C, Blier P, Debonnel G: Effects of sustained administration of the serotonin and norepinephrine reuptake inhibitor venlafaxine: I. in vivo electrophysiological studies in the rat. Neuropharmacology. 2000 Jul 24;39(10):1800-12. [PubMed:10884561 ]
  8. Westenberg HG: Recent advances in understanding and treating social anxiety disorder. CNS Spectr. 2009 Feb;14(2 Suppl 3):24-33. [PubMed:19238127 ]
  9. Sindrup SH, Otto M, Finnerup NB, Jensen TS: Antidepressants in the treatment of neuropathic pain. Basic Clin Pharmacol Toxicol. 2005 Jun;96(6):399-409. [PubMed:15910402 ]
Kind
Protein
Organism
Human
Pharmacological action
yes
Actions
inhibitor
General Function:
Norepinephrine:sodium symporter activity
Specific Function:
Amine transporter. Terminates the action of noradrenaline by its high affinity sodium-dependent reuptake into presynaptic terminals.
Gene Name:
SLC6A2
Uniprot ID:
P23975
Molecular Weight:
69331.42 Da
References
  1. Vaishnavi SN, Nemeroff CB, Plott SJ, Rao SG, Kranzler J, Owens MJ: Milnacipran: a comparative analysis of human monoamine uptake and transporter binding affinity. Biol Psychiatry. 2004 Feb 1;55(3):320-2. [PubMed:14744476 ]
  2. Mitchell HA, Ahern TH, Liles LC, Javors MA, Weinshenker D: The effects of norepinephrine transporter inactivation on locomotor activity in mice. Biol Psychiatry. 2006 Nov 15;60(10):1046-52. Epub 2006 Aug 7. [PubMed:16893531 ]
  3. Beique JC, Lavoie N, de Montigny C, Debonnel G: Affinities of venlafaxine and various reuptake inhibitors for the serotonin and norepinephrine transporters. Eur J Pharmacol. 1998 May 15;349(1):129-32. [PubMed:9669506 ]
  4. Van Ameringen M, Mancini C, Patterson B, Simpson W: Pharmacotherapy for social anxiety disorder: an update. Isr J Psychiatry Relat Sci. 2009;46(1):53-61. [PubMed:19728573 ]
  5. Beique J, de Montigny C, Blier P, Debonnel G: Effects of sustained administration of the serotonin and norepinephrine reuptake inhibitor venlafaxine: I. in vivo electrophysiological studies in the rat. Neuropharmacology. 2000 Jul 24;39(10):1800-12. [PubMed:10884561 ]
  6. Westenberg HG: Recent advances in understanding and treating social anxiety disorder. CNS Spectr. 2009 Feb;14(2 Suppl 3):24-33. [PubMed:19238127 ]
  7. Sindrup SH, Otto M, Finnerup NB, Jensen TS: Antidepressants in the treatment of neuropathic pain. Basic Clin Pharmacol Toxicol. 2005 Jun;96(6):399-409. [PubMed:15910402 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Monoamine transmembrane transporter activity
Specific Function:
Amine transporter. Terminates the action of dopamine by its high affinity sodium-dependent reuptake into presynaptic terminals.
Gene Name:
SLC6A3
Uniprot ID:
Q01959
Molecular Weight:
68494.255 Da
References
  1. Dawson LA, Nguyen HQ, Geiger A: Effects of venlafaxine on extracellular concentrations of 5-HT and noradrenaline in the rat frontal cortex: augmentation via 5-HT1A receptor antagonism. Neuropharmacology. 1999 Aug;38(8):1153-63. [PubMed:10462128 ]
  2. Bourin M: [Psychopharmacological profile of venlafaxine]. Encephale. 1999 Jun;25 Spec No 2:21-2; discussion 23-5. [PubMed:10434156 ]
  3. Barkin RL, Fawcett J: The management challenges of chronic pain: the role of antidepressants. Am J Ther. 2000 Jan;7(1):31-47. [PubMed:11319571 ]
  4. Lemke MR: [Antidepressant effects of dopamine agonists. Experimental and clinical findings]. Nervenarzt. 2007 Jan;78(1):31-8. [PubMed:17187269 ]

Enzymes

Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrateinhibitor
General Function:
Steroid hydroxylase activity
Specific Function:
Responsible for the metabolism of many drugs and environmental chemicals that it oxidizes. It is involved in the metabolism of drugs such as antiarrhythmics, adrenoceptor antagonists, and tricyclic antidepressants.
Gene Name:
CYP2D6
Uniprot ID:
P10635
Molecular Weight:
55768.94 Da
References
  1. Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. [PubMed:19515014 ]
  2. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
  3. Fogelman SM, Schmider J, Venkatakrishnan K, von Moltke LL, Harmatz JS, Shader RI, Greenblatt DJ: O- and N-demethylation of venlafaxine in vitro by human liver microsomes and by microsomes from cDNA-transfected cells: effect of metabolic inhibitors and SSRI antidepressants. Neuropsychopharmacology. 1999 May;20(5):480-90. [PubMed:10192828 ]
  4. Drug Interactions: Cytochrome P450 Drug Interaction Table [Link]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrateinhibitor
General Function:
Vitamin d3 25-hydroxylase activity
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It performs a variety of oxidation reactions (e.g. caffeine 8-oxidation, omeprazole sulphoxidation, midazolam 1'-hydroxylation and midazolam 4-hydroxylation) of structurally unrelated compounds, including steroids, fatty acids, and xenobiot...
Gene Name:
CYP3A4
Uniprot ID:
P08684
Molecular Weight:
57342.67 Da
References
  1. Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. [PubMed:19515014 ]
  2. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrate
General Function:
Steroid hydroxylase activity
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. This enzyme contributes to the wide pharmacokinetics variability of the metabolism of drugs such as S-warfarin, diclofenac, phenyto...
Gene Name:
CYP2C9
Uniprot ID:
P11712
Molecular Weight:
55627.365 Da
References
  1. Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. [PubMed:19515014 ]
  2. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrate
General Function:
Steroid hydroxylase activity
Specific Function:
Responsible for the metabolism of a number of therapeutic agents such as the anticonvulsant drug S-mephenytoin, omeprazole, proguanil, certain barbiturates, diazepam, propranolol, citalopram and imipramine.
Gene Name:
CYP2C19
Uniprot ID:
P33261
Molecular Weight:
55930.545 Da
References
  1. Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. [PubMed:19515014 ]
  2. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Steroid hydroxylase activity
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. Acts as a 1,4-cineole 2-exo-monooxygenase.
Gene Name:
CYP2B6
Uniprot ID:
P20813
Molecular Weight:
56277.81 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]

Transporters

Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrateinhibitor
General Function:
Xenobiotic-transporting atpase activity
Specific Function:
Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells.
Gene Name:
ABCB1
Uniprot ID:
P08183
Molecular Weight:
141477.255 Da
References
  1. Weiss J, Dormann SM, Martin-Facklam M, Kerpen CJ, Ketabi-Kiyanvash N, Haefeli WE: Inhibition of P-glycoprotein by newer antidepressants. J Pharmacol Exp Ther. 2003 Apr;305(1):197-204. [PubMed:12649369 ]
  2. Uhr M, Grauer MT, Holsboer F: Differential enhancement of antidepressant penetration into the brain in mice with abcb1ab (mdr1ab) P-glycoprotein gene disruption. Biol Psychiatry. 2003 Oct 15;54(8):840-6. [PubMed:14550684 ]
  3. Karlsson L, Schmitt U, Josefsson M, Carlsson B, Ahlner J, Bengtsson F, Kugelberg FC, Hiemke C: Blood-brain barrier penetration of the enantiomers of venlafaxine and its metabolites in mice lacking P-glycoprotein. Eur Neuropsychopharmacol. 2010 Sep;20(9):632-40. doi: 10.1016/j.euroneuro.2010.04.004. Epub 2010 May 13. [PubMed:20466523 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inducer
General Function:
Xenobiotic-transporting atpase activity
Specific Function:
High-capacity urate exporter functioning in both renal and extrarenal urate excretion. Plays a role in porphyrin homeostasis as it is able to mediates the export of protoporhyrin IX (PPIX) both from mitochondria to cytosol and from cytosol to extracellular space, and cellular export of hemin, and heme. Xenobiotic transporter that may play an important role in the exclusion of xenobiotics from t...
Gene Name:
ABCG2
Uniprot ID:
Q9UNQ0
Molecular Weight:
72313.47 Da
References
  1. Bachmeier CJ, Beaulieu-Abdelahad D, Ganey NJ, Mullan MJ, Levin GM: Induction of drug efflux protein expression by venlafaxine but not desvenlafaxine. Biopharm Drug Dispos. 2011 May;32(4):233-44. doi: 10.1002/bdd.753. Epub 2011 Mar 28. [PubMed:21446053 ]
Comments
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Drug created on June 13, 2005 07:24 / Updated on December 07, 2016 03:54