Displaying drugs 3651 - 3675 of 11736 in total
Voxelotor
Voxelotor is a novel hemoglobin S polymerization inhibitor for the treatment of sickle cell disease. This is a genetically inherited condition most prevalent in the Middle East, Africa, and certain parts of India. Sickle cell disease can lead to excruciating pain, stroke, infection, and various other complications arising from the...
Approved
Investigational
Matched Description: … Voxelotor is a novel hemoglobin S polymerization inhibitor for the treatment of sickle cell disease. ... This is a genetically inherited condition most prevalent in the Middle East, Africa, and certain parts ... [T734]
Voxelotor was granted accelerated FDA approval on November 25 2019, as it is likely to be a …
Allenrolfea occidentalis pollen
Allenrolfea occidentalis pollen is the pollen of the Allenrolfea occidentalis plant. Allenrolfea occidentalis pollen is mainly used in allergenic testing.
Approved
Polistes annularis venom protein
Polistes annularis venom protein is an extract of Polistes annularis venom. Polistes annularis venom protein is used in allergenic testing.
Approved
Fluvastatin
Fluvastatin is an antilipemic agent that competitively inhibits hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonic acid, the rate-limiting step in cholesterol biosynthesis. Fluvastatin belongs to a class of medications called statins and is used to reduce plasma cholesterol levels and prevent cardiovascular disease. It...
Approved
Matched Description: … Fluvastatin is a racemate comprising equimolar amounts of (3R,5S)- and (3S,5R)-fluvastatin. ... Fluvastatin is an antilipemic agent that competitively inhibits hydroxymethylglutaryl-coenzyme A (HMG-CoA ... Fluvastatin belongs to a class of medications called statins and is used to reduce plasma cholesterol …
Solifenacin
Solifenacin is a competitive muscarinic receptor antagonist indicated to treat an overactive bladder with urinary incontinence, urgency, and frequency. It has a long duration of action as it is usually taken once daily. Solifenacin was granted FDA approval on 19 November 2004.
Approved
Matched Description: … [L7511] It has a long duration of action as it is usually taken once daily. ... Solifenacin is a competitive muscarinic receptor antagonist indicated to treat an overactive bladder …
Laurocapram
Approved
Human Rho(D) immune globulin
Human Rho(D) immune globulin is a medicine given by intramuscular or intravenous injection that is used to prevent the immunological condition known as Rh disease (or hemolytic disease of newborn). Rho (D) immune globulin is available as a sterile, lyophilized or liquid gamma globulin (IgG) fraction containing antibodies to the...
Approved
Investigational
Matched Description: … Human Rho(D) immune globulin is a medicine given by intramuscular or intravenous injection that is used ... Rho (D) immune globulin is available as a sterile, lyophilized or liquid gamma globulin (IgG) fraction …
Zileuton
Leukotrienes are substances that induce numerous biological effects including augmentation of neutrophil and eosinophil migration, neutrophil and monocyte aggregation, leukocyte adhesion, increased capillary permeability, and smooth muscle contraction. These effects contribute to inflammation, edema, mucus secretion, and bronchoconstriction in the airways of asthmatic patients. Zileuton relieves such symptoms through its...
Approved
Investigational
Withdrawn
Enzalutamide
Enzalutamide is an androgen receptor (AR) inhibitor for the treatment of castration-resistant prostate cancer (CRPC), both metastatic and non-metastatic. It is a second-generation antiandrogen agent that the FDA approved on August 31, 2012.[L40639, A252667] Although androgen deprivation therapy (ADT) is the first-line treatment of prostate cancer and remission can be...
Approved
Matched Description: … [A252667,A252642]
Due to a favorable pharmacological profile, a phase 1 study of enzalutamide was ... [L40639] It is a second-generation antiandrogen agent that the FDA approved on August 31, 2012. ... Compared to the average time of 10 to 15 years for a drug to go from pre-clinical to clinical studies …
Brexpiprazole
Brexpiprazole is an atypical antipsychotic and a novel D2 dopamine and serotonin 1A partial agonist called serotonin-dopamine activity modulator (SDAM). It has a high affinity for serotonin, dopamine and alpha (α)-adrenergic receptors. Although it is structurally similar to aripiprazole, brexpiprazole has different binding affinities for dopamine and serotonin receptors. Compared...
Approved
Investigational
Matched Description: … It has a high affinity for serotonin, dopamine and alpha (α)-adrenergic receptors. ... Brexpiprazole is an atypical antipsychotic and a novel D2 dopamine and serotonin 1A partial agonist called …
Rabies virus inactivated antigen, B
Inactivated rabies virus antigen B is a component of rabies vaccines used for pre- and post-exposure prophylaxis against rabies.
Approved
Matched Description: … Inactivated rabies virus antigen B is a component of rabies vaccines used for pre- and post-exposure …
Diaminopropanol tetraacetic acid
Diaminohydroxypropanetetraacetic acid has been investigated for the treatment of Vascular Disease, Coronary Disease, Myocardial Ischemia, Coronary Restenosis, and Coronary Artery Disease, among others.
Approved
Investigational
Lipegfilgrastim
Lipegfilgrastim, previously known as XM22, is a pegylated, recombinant granulocyte colony-stimulating factor (G-CSF) that was synthetized using a highly site-specific glycoPEGylation technology . It is used as an alternate to DB00019 for prophylactic use in cancer patients receiving chemotherapy and at risk for developing chemotherapy-induced neutropenia. Since July 2013, lipegfilgrastim...
Approved
Investigational
Matched Description: … Lipegfilgrastim is a covalent conjugate of [DB00099] with a single methoxy polyethylene glycol (PEG) ... Lipegfilgrastim, previously known as XM22, is a pegylated, recombinant granulocyte colony-stimulating ... factor (G-CSF) that was synthetized using a highly site-specific glycoPEGylation technology [A32665] …
Vortioxetine
Vortioxetine is an antidepressant medication indicated for the treatment of major depressive disorder (MDD). It is classified as a serotonin modulator and stimulator (SMS) as it has a multimodal mechanism of action towards the serotonin neurotransmitter system whereby it simultaneously modulates one or more serotonin receptors and inhibits the reuptake...
Approved
Investigational
Matched Description: … It is classified as a serotonin modulator and stimulator (SMS) as it has a multimodal mechanism of action ... More specifically, vortioxetine acts via the following biological mechanisms: as a serotonin reuptake ... inhibitor (SRI) through inhibition of the serotonin transporter, as a partial agonist of the 5-HT1B …
Indium In-111 oxyquinoline
Indium In 111 oxyquinoline (oxine) is a diagnostic radiopharmaceutical intended for radiolabeling of autologous leukocytes. It is composed of a 3:1 saturated complex of In-111 isotope and oxyquinoline. Indium-111 decays by isomeric transition and electron capture to cadmium-111, emitting a gamma ray that can be detected with a gamma ray...
Approved
Matched Description: … can be detected with a gamma ray camera. ... It is composed of a 3:1 saturated complex of In-111 isotope and oxyquinoline. ... Indium In 111 oxyquinoline (oxine) is a diagnostic radiopharmaceutical intended for radiolabeling of …
Ranitidine
Ranitidine is a commonly used drug, classified as a histamine H2-receptor antagonist, and belongs to the same drug class as cimetidine and famotidine. This drug helps to prevent and treat gastric-acid associated conditions, including ulcers, because of its ability to decrease gastric acid secretion.[A176759,L10818] Ranitidine is often referred to as...
Approved
Withdrawn
Matched Description: … Ranitidine is a commonly used drug, classified as a histamine H2-receptor antagonist, and belongs to …
Trospium
Trospium is an antispasmodic agent used to treat the symptoms of overactive bladder, a condition that causes the bladder muscles to contract uncontrollably. An overactive bladder leads to an increased urge to urinate, frequent urination, and sometimes, loss of control over urination. Trospium is manufactured by Indevus Pharmaceutical Inc. and...
Approved
Matched Description: … Trospium is an antispasmodic agent used to treat the symptoms of overactive bladder, a condition that …
Ritonavir
Ritonavir is an HIV protease inhibitor that interferes with the reproductive cycle of HIV. Although it was initially developed as an independent antiviral agent, it has been shown to possess advantageous properties in combination regimens with low-dose ritonavir and other protease inhibitors. It is now more commonly used as a...
Approved
Investigational
Matched Description: … Any HCV/HIV-1 co-infected patients treated with ritonavir-containing combination therapies should also ... It is now more commonly used as a booster of other protease inhibitors and is available in both liquid ... HCV) infection, it is added in combination therapies indicated for the treatment of HCV infections as a …
Propoxycaine
Propoxycaine is a local anesthetic of the ester type that has a rapid onset of action and a longer duration of action than procaine hydrochloride . This drug was removed from the US market in 1996. Although no longer available in the United States, this medication was used in combination...
Approved
Matched Description: … Propoxycaine is a local anesthetic of the ester type that has a rapid onset of action and a longer duration …
Toripalimab
The proliferation of some cancers can be attributed, at least in part, to the suppression of host tumor surveillance. One mechanism by which this occurs is through the overexpression of programmed cell death ligand (PD-L1) - the binding of PD-L1 (and PD-L2) to its target receptor (PD-1) results in the...
Approved
Investigational
Matched Description: … [L48681]
Toripalimab is a selective, recombinant, humanized IgG4 monoclonal antibody targeted against …
Pemigatinib
Pemigatinib is a small molecule kinase inhibitor with antitumour activity. It works by inhibiting fibroblast growth factor receptors (FGFRs), which are receptor tyrosine kinases that activate signalling pathways in tumour cells. FGFRs gained attention as potential therapeutic targets in selected cancers, as FGFR gene alterations were observed in a wide...
Approved
Investigational
Matched Description: … Pemigatinib is a small molecule kinase inhibitor with antitumour activity. ... attention as potential therapeutic targets in selected cancers, as FGFR gene alterations were observed in a ... unresectable locally advanced or metastatic cholangiocarcinoma in previously treated adult patients with a …
Liothyronine
Liothyronine is a thyroidal hormone T3 which is normally produced by the thyroid gland in a ratio 4:1 when compared with T4: T3. Liothyronine is the active form of thyroxine which is composed in a basic chemical structure by a tyrosine with bound iodine. The exogenous liothyronine product was developed...
Approved
Vet approved
Matched Description: … Liothyronine is a thyroidal hormone T3 which is normally produced by the thyroid gland in a ratio 4:1 ... Liothyronine is the active form of thyroxine which is composed in a basic chemical structure by a tyrosine …
Telotristat ethyl
Telotristat ethyl is a prodrug of telotristat that was approved by the FDA in March 2017 as Xermelo. It was previously referred to as telotristat etiprate, the hippurate salt form; however, the FDA recommends the use of the name of the neutral form rather than that of the salt.[A252937, A252942]...
Approved
Investigational
Matched Description: … Telotristat ethyl is a prodrug of telotristat that was approved by the FDA in March 2017 as Xermelo. ... can therefore secrete chemical mediators into the bloodstream to cause side effects in distant sites, a …
Displaying drugs 3651 - 3675 of 11736 in total