Identification

Name
Propoxycaine
Accession Number
DB09342
Type
Small Molecule
Groups
Approved
Description

Propoxycaine is a local anesthetic of the ester type that has a rapid onset of action and a longer duration of action than procaine hydrochloride [3]. This drug was removed from the US market in 1996. Although no longer available in the United States, this medication was used in combination with procaine to aid in anesthesia during dental procedures [5]. Used in combination with procaine, it was the only dental local anesthetic available in cartridge form [5].

Structure
Thumb
Synonyms
Not Available
Product Ingredients
IngredientUNIICASInChI Key
Propoxycaine hydrochlorideK490D39G46550-83-4GITPCGSPKUQZTE-UHFFFAOYSA-N
Categories
UNII
EPD1EH7F53
CAS number
86-43-1
Weight
Average: 294.395
Monoisotopic: 294.194342705
Chemical Formula
C16H26N2O3
InChI Key
CAJIGINSTLKQMM-UHFFFAOYSA-N
InChI
InChI=1S/C16H26N2O3/c1-4-10-20-15-12-13(17)7-8-14(15)16(19)21-11-9-18(5-2)6-3/h7-8,12H,4-6,9-11,17H2,1-3H3
IUPAC Name
2-(diethylamino)ethyl 4-amino-2-propoxybenzoate
SMILES
CCCOC1=CC(N)=CC=C1C(=O)OCCN(CC)CC

Pharmacology

Indication

Propoxycaine is a local anesthetic medication. It was used beginning in the 1950s during dental procedures [4]. It has been combined with procaine to accelerate its onset of action and provide longer-lasting anesthetic effect [5].

It was produced for use when amide local anesthetics were contraindicated due to allergy or when several amide anesthetics were unsuccessful [5].

Pharmacodynamics

Propoxycaine is a local anesthetic which acts to decrease nerve impulses and therefore pain sensation during dental procedures [4, 5, 6].

Mechanism of action

Propoxycaine is a para-aminobenzoic acid ester with local anesthetic activity. Propoxycaine binds to and blocks voltage-gated sodium channels, thereby inhibiting the ionic flux essential for the conduction of nerve impulses. This results in a loss of sensation [3].

In one study, propoxycaine hydrochloride increased annular lipid fluidity in cell lipid bilayers and had a greater fluidizing effect on the inner monolayer than that of the outer monolayer [2]. This may further confirm its role in modulating neural impulses.

TargetActionsOrganism
UVoltage gated sodium channel
antagonist
human
Absorption
Not Available
Volume of distribution
Not Available
Protein binding
Not Available
Metabolism

This drug his hydrolyzed in both the plasma and the liver by plasma esterases [6].

Route of elimination

Renal [5]

Half life
Not Available
Clearance

Via the kidneys, primarily hydrolyzed [5].

Toxicity

The toxicity of this medication (7-8 times higher than that of procaine), has prevented this medication from being used on its own [5].

Ester-type local anesthetics are much more likely to cause an allergic reaction compared to the amide-group local anesthetics because of the formation of PABA (Para-aminobenzoic acid) during the metabolic process. PABA may cause allergic reactions that range from urticaria to anaphylaxis. PABA is also formed during the metabolism of methylparaben (a common preservative) that is normally found in multi-dose vials including lidocaine (MDV) (amide-type local anesthetic) [5, 6].

Affected organisms
Not Available
Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
DrugInteractionDrug group
7-NitroindazoleThe risk or severity of adverse effects can be increased when 7-Nitroindazole is combined with Propoxycaine.Experimental
AcepromazineThe risk or severity of adverse effects can be increased when Acepromazine is combined with Propoxycaine.Approved, Vet Approved
AceprometazineThe risk or severity of adverse effects can be increased when Aceprometazine is combined with Propoxycaine.Approved
AdipiplonThe risk or severity of adverse effects can be increased when Adipiplon is combined with Propoxycaine.Investigational
AgomelatineThe risk or severity of adverse effects can be increased when Agomelatine is combined with Propoxycaine.Approved, Investigational
AlaproclateThe risk or severity of adverse effects can be increased when Propoxycaine is combined with Alaproclate.Experimental
AlfaxaloneThe risk or severity of adverse effects can be increased when Propoxycaine is combined with Alfaxalone.Vet Approved
AlfentanilThe risk or severity of adverse effects can be increased when Alfentanil is combined with Propoxycaine.Approved, Illicit
AllopregnanoloneThe risk or severity of adverse effects can be increased when Propoxycaine is combined with Allopregnanolone.Investigational
AlphacetylmethadolThe risk or severity of adverse effects can be increased when Alphacetylmethadol is combined with Propoxycaine.Experimental, Illicit
AlphaprodineThe risk or severity of adverse effects can be increased when Propoxycaine is combined with Alphaprodine.Illicit
AlprazolamThe risk or severity of adverse effects can be increased when Alprazolam is combined with Propoxycaine.Approved, Illicit, Investigational
AmisulprideThe risk or severity of adverse effects can be increased when Amisulpride is combined with Propoxycaine.Approved, Investigational
AmitriptylineThe risk or severity of adverse effects can be increased when Amitriptyline is combined with Propoxycaine.Approved
AmobarbitalThe risk or severity of adverse effects can be increased when Amobarbital is combined with Propoxycaine.Approved, Illicit
AmoxapineThe risk or severity of adverse effects can be increased when Amoxapine is combined with Propoxycaine.Approved
AmperozideThe risk or severity of adverse effects can be increased when Amperozide is combined with Propoxycaine.Experimental
AripiprazoleThe risk or severity of adverse effects can be increased when Aripiprazole is combined with Propoxycaine.Approved, Investigational
ArticaineThe risk or severity of adverse effects can be increased when Articaine is combined with Propoxycaine.Approved
AsenapineThe risk or severity of adverse effects can be increased when Asenapine is combined with Propoxycaine.Approved
AzaperoneThe risk or severity of adverse effects can be increased when Propoxycaine is combined with Azaperone.Investigational, Vet Approved
AzelastinePropoxycaine may increase the central nervous system depressant (CNS depressant) activities of Azelastine.Approved
BaclofenThe risk or severity of adverse effects can be increased when Baclofen is combined with Propoxycaine.Approved
BarbitalThe risk or severity of adverse effects can be increased when Barbital is combined with Propoxycaine.Illicit
BenperidolThe risk or severity of adverse effects can be increased when Propoxycaine is combined with Benperidol.Approved, Investigational
BrexpiprazoleThe risk or severity of adverse effects can be increased when Brexpiprazole is combined with Propoxycaine.Approved, Investigational
BrimonidineBrimonidine may increase the central nervous system depressant (CNS depressant) activities of Propoxycaine.Approved
BromazepamThe risk or severity of adverse effects can be increased when Bromazepam is combined with Propoxycaine.Approved, Illicit, Investigational
BromisovalThe risk or severity of adverse effects can be increased when Propoxycaine is combined with Bromisoval.Experimental
BromperidolThe risk or severity of adverse effects can be increased when Propoxycaine is combined with Bromperidol.Approved, Investigational
BrotizolamThe risk or severity of adverse effects can be increased when Brotizolam is combined with Propoxycaine.Approved, Investigational, Withdrawn
BupivacaineThe risk or severity of adverse effects can be increased when Bupivacaine is combined with Propoxycaine.Approved, Investigational
BuprenorphinePropoxycaine may increase the central nervous system depressant (CNS depressant) activities of Buprenorphine.Approved, Illicit, Investigational, Vet Approved
BuspironeThe risk or severity of adverse effects can be increased when Buspirone is combined with Propoxycaine.Approved, Investigational
ButabarbitalThe risk or severity of adverse effects can be increased when Butabarbital is combined with Propoxycaine.Approved, Illicit
ButacaineThe risk or severity of adverse effects can be increased when Propoxycaine is combined with Butacaine.Vet Approved
ButalbitalThe risk or severity of adverse effects can be increased when Butalbital is combined with Propoxycaine.Approved, Illicit
ButambenThe risk or severity of adverse effects can be increased when Propoxycaine is combined with Butamben.Approved, Withdrawn
ButethalThe risk or severity of adverse effects can be increased when Butethal is combined with Propoxycaine.Approved, Illicit
ButorphanolThe risk or severity of adverse effects can be increased when Butorphanol is combined with Propoxycaine.Approved, Illicit, Vet Approved
CanertinibThe risk or severity of adverse effects can be increased when Canertinib is combined with Propoxycaine.Investigational
CarbinoxamineThe risk or severity of adverse effects can be increased when Carbinoxamine is combined with Propoxycaine.Approved
CarfentanilThe risk or severity of adverse effects can be increased when Carfentanil is combined with Propoxycaine.Illicit, Investigational, Vet Approved
CarisoprodolThe risk or severity of adverse effects can be increased when Carisoprodol is combined with Propoxycaine.Approved
Chloral hydrateThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Propoxycaine.Approved, Illicit, Investigational, Vet Approved
ChlordiazepoxideThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Propoxycaine.Approved, Illicit, Investigational
ChlormezanoneThe risk or severity of adverse effects can be increased when Chlormezanone is combined with Propoxycaine.Approved, Investigational, Withdrawn
ChloroprocaineThe risk or severity of adverse effects can be increased when Chloroprocaine is combined with Propoxycaine.Approved
ChlorpromazineThe risk or severity of adverse effects can be increased when Chlorpromazine is combined with Propoxycaine.Approved, Investigational, Vet Approved
ChlorprothixeneThe risk or severity of adverse effects can be increased when Chlorprothixene is combined with Propoxycaine.Approved, Investigational, Withdrawn
ChlorzoxazoneThe risk or severity of adverse effects can be increased when Chlorzoxazone is combined with Propoxycaine.Approved
CinchocaineThe risk or severity of adverse effects can be increased when Cinchocaine is combined with Propoxycaine.Approved, Vet Approved
CitalopramThe risk or severity of adverse effects can be increased when Propoxycaine is combined with Citalopram.Approved
ClidiniumThe risk or severity of adverse effects can be increased when Clidinium is combined with Propoxycaine.Approved
ClobazamThe risk or severity of adverse effects can be increased when Clobazam is combined with Propoxycaine.Approved, Illicit
clomethiazoleThe risk or severity of adverse effects can be increased when clomethiazole is combined with Propoxycaine.Investigational
ClomipramineThe risk or severity of adverse effects can be increased when Clomipramine is combined with Propoxycaine.Approved, Investigational, Vet Approved
ClonazepamThe risk or severity of adverse effects can be increased when Clonazepam is combined with Propoxycaine.Approved, Illicit
ClonidineThe risk or severity of adverse effects can be increased when Clonidine is combined with Propoxycaine.Approved
ClopenthixolThe risk or severity of adverse effects can be increased when Propoxycaine is combined with Clopenthixol.Experimental
ClorazepateThe risk or severity of adverse effects can be increased when Clorazepate is combined with Propoxycaine.Approved, Illicit
ClothiapineThe risk or severity of adverse effects can be increased when Propoxycaine is combined with Clothiapine.Experimental
ClozapineThe risk or severity of adverse effects can be increased when Clozapine is combined with Propoxycaine.Approved
CocaineThe risk or severity of adverse effects can be increased when Cocaine is combined with Propoxycaine.Approved, Illicit
CyclizineThe risk or severity of adverse effects can be increased when Cyclizine is combined with Propoxycaine.Approved
CyclopropaneThe risk or severity of adverse effects can be increased when Propoxycaine is combined with Cyclopropane.Experimental
CyproheptadineThe risk or severity of adverse effects can be increased when Cyproheptadine is combined with Propoxycaine.Approved
DantroleneThe risk or severity of adverse effects can be increased when Dantrolene is combined with Propoxycaine.Approved, Investigational
DapiprazoleThe risk or severity of adverse effects can be increased when Dapiprazole is combined with Propoxycaine.Approved
DapoxetineThe risk or severity of adverse effects can be increased when Propoxycaine is combined with Dapoxetine.Investigational
DeramciclaneThe risk or severity of adverse effects can be increased when Deramciclane is combined with Propoxycaine.Investigational
DesfluraneThe risk or severity of adverse effects can be increased when Desflurane is combined with Propoxycaine.Approved
DesipramineThe risk or severity of adverse effects can be increased when Desipramine is combined with Propoxycaine.Approved, Investigational
DesloratadineThe risk or severity of adverse effects can be increased when Desloratadine is combined with Propoxycaine.Approved, Investigational
DetomidineThe risk or severity of adverse effects can be increased when Propoxycaine is combined with Detomidine.Vet Approved
DexmedetomidineThe risk or severity of adverse effects can be increased when Dexmedetomidine is combined with Propoxycaine.Approved, Vet Approved
DextromoramideThe risk or severity of adverse effects can be increased when Dextromoramide is combined with Propoxycaine.Experimental, Illicit
DextropropoxypheneThe risk or severity of adverse effects can be increased when Dextropropoxyphene is combined with Propoxycaine.Approved, Illicit, Investigational, Withdrawn
DiazepamThe risk or severity of adverse effects can be increased when Diazepam is combined with Propoxycaine.Approved, Illicit, Investigational, Vet Approved
Diethyl etherThe risk or severity of adverse effects can be increased when Propoxycaine is combined with Diethyl ether.Experimental
DifenoxinThe risk or severity of adverse effects can be increased when Difenoxin is combined with Propoxycaine.Approved, Illicit
DihydrocodeineThe risk or severity of adverse effects can be increased when Dihydrocodeine is combined with Propoxycaine.Approved, Illicit
DihydroetorphineThe risk or severity of adverse effects can be increased when Dihydroetorphine is combined with Propoxycaine.Experimental, Illicit
DihydromorphineThe risk or severity of adverse effects can be increased when Dihydromorphine is combined with Propoxycaine.Experimental, Illicit
DiphenoxylateThe risk or severity of adverse effects can be increased when Diphenoxylate is combined with Propoxycaine.Approved, Illicit
DixyrazineThe risk or severity of adverse effects can be increased when Propoxycaine is combined with Dixyrazine.Experimental
DoramectinThe risk or severity of adverse effects can be increased when Propoxycaine is combined with Doramectin.Vet Approved
DoxepinThe risk or severity of adverse effects can be increased when Doxepin is combined with Propoxycaine.Approved, Investigational
DPDPEThe risk or severity of adverse effects can be increased when DPDPE is combined with Propoxycaine.Experimental
DronabinolDronabinol may increase the central nervous system depressant (CNS depressant) activities of Propoxycaine.Approved, Illicit
DroperidolDroperidol may increase the central nervous system depressant (CNS depressant) activities of Propoxycaine.Approved, Vet Approved
DrotebanolThe risk or severity of adverse effects can be increased when Drotebanol is combined with Propoxycaine.Experimental, Illicit
DuloxetineThe risk or severity of adverse effects can be increased when Propoxycaine is combined with Duloxetine.Approved
DyclonineThe risk or severity of adverse effects can be increased when Dyclonine is combined with Propoxycaine.Approved
EcgonineThe risk or severity of adverse effects can be increased when Ecgonine is combined with Propoxycaine.Experimental, Illicit
EcopipamThe risk or severity of adverse effects can be increased when Propoxycaine is combined with Ecopipam.Investigational
EfavirenzThe risk or severity of adverse effects can be increased when Efavirenz is combined with Propoxycaine.Approved, Investigational
EltanoloneThe risk or severity of adverse effects can be increased when Propoxycaine is combined with Eltanolone.Investigational
EnfluraneThe risk or severity of adverse effects can be increased when Enflurane is combined with Propoxycaine.Approved, Investigational, Vet Approved
EntacaponeThe risk or severity of adverse effects can be increased when Entacapone is combined with Propoxycaine.Approved, Investigational
EscitalopramThe risk or severity of adverse effects can be increased when Propoxycaine is combined with Escitalopram.Approved, Investigational
EstazolamThe risk or severity of adverse effects can be increased when Estazolam is combined with Propoxycaine.Approved, Illicit
EszopicloneThe risk or severity of adverse effects can be increased when Eszopiclone is combined with Propoxycaine.Approved, Investigational
EthchlorvynolThe risk or severity of adverse effects can be increased when Ethchlorvynol is combined with Propoxycaine.Approved, Illicit, Withdrawn
EthotoinThe risk or severity of adverse effects can be increased when Ethotoin is combined with Propoxycaine.Approved
Ethyl carbamateThe risk or severity of adverse effects can be increased when Ethyl carbamate is combined with Propoxycaine.Withdrawn
Ethyl chlorideThe risk or severity of adverse effects can be increased when Propoxycaine is combined with Ethyl chloride.Approved, Experimental, Investigational
Ethyl loflazepateThe risk or severity of adverse effects can be increased when Ethyl loflazepate is combined with Propoxycaine.Approved, Illicit
EthylmorphineThe risk or severity of adverse effects can be increased when Ethylmorphine is combined with Propoxycaine.Approved, Illicit
EtidocaineThe risk or severity of adverse effects can be increased when Etidocaine is combined with Propoxycaine.Approved
EtifoxineThe risk or severity of adverse effects can be increased when Etifoxine is combined with Propoxycaine.Investigational, Withdrawn
EtizolamThe risk or severity of adverse effects can be increased when Etizolam is combined with Propoxycaine.Approved
EtoperidoneThe risk or severity of adverse effects can be increased when Propoxycaine is combined with Etoperidone.Withdrawn
EtorphineThe risk or severity of adverse effects can be increased when Etorphine is combined with Propoxycaine.Illicit, Vet Approved
EzogabineThe risk or severity of adverse effects can be increased when Ezogabine is combined with Propoxycaine.Approved, Investigational
FelbamateThe risk or severity of adverse effects can be increased when Felbamate is combined with Propoxycaine.Approved
FencamfamineThe risk or severity of adverse effects can be increased when Fencamfamine is combined with Propoxycaine.Approved, Illicit, Withdrawn
FexofenadineThe risk or severity of adverse effects can be increased when Fexofenadine is combined with Propoxycaine.Approved, Investigational
FlibanserinThe risk or severity of adverse effects can be increased when Flibanserin is combined with Propoxycaine.Approved, Investigational
FluanisoneThe risk or severity of adverse effects can be increased when Propoxycaine is combined with Fluanisone.Experimental
FludiazepamThe risk or severity of adverse effects can be increased when Fludiazepam is combined with Propoxycaine.Approved, Illicit
FlunitrazepamThe risk or severity of adverse effects can be increased when Flunitrazepam is combined with Propoxycaine.Approved, Illicit
FlupentixolThe risk or severity of adverse effects can be increased when Flupentixol is combined with Propoxycaine.Approved, Investigational, Withdrawn
FluphenazineThe risk or severity of adverse effects can be increased when Fluphenazine is combined with Propoxycaine.Approved
FlurazepamThe risk or severity of adverse effects can be increased when Flurazepam is combined with Propoxycaine.Approved, Illicit, Investigational
FospropofolThe risk or severity of adverse effects can be increased when Fospropofol is combined with Propoxycaine.Approved, Illicit, Investigational
Gabapentin EnacarbilThe risk or severity of adverse effects can be increased when Gabapentin Enacarbil is combined with Propoxycaine.Approved, Investigational
Gamma Hydroxybutyric AcidThe risk or severity of adverse effects can be increased when Gamma Hydroxybutyric Acid is combined with Propoxycaine.Approved, Illicit, Investigational
GepironeThe risk or severity of adverse effects can be increased when Propoxycaine is combined with Gepirone.Investigational
GlutethimideThe risk or severity of adverse effects can be increased when Glutethimide is combined with Propoxycaine.Approved, Illicit
HalazepamThe risk or severity of adverse effects can be increased when Halazepam is combined with Propoxycaine.Approved, Illicit, Withdrawn
HaloperidolThe risk or severity of adverse effects can be increased when Haloperidol is combined with Propoxycaine.Approved
HalothaneThe risk or severity of adverse effects can be increased when Halothane is combined with Propoxycaine.Approved, Vet Approved
HeroinThe risk or severity of adverse effects can be increased when Heroin is combined with Propoxycaine.Approved, Illicit, Investigational
HexobarbitalThe risk or severity of adverse effects can be increased when Hexobarbital is combined with Propoxycaine.Approved
HyaluronidaseThe risk or severity of adverse effects can be increased when Hyaluronidase is combined with Propoxycaine.Approved, Investigational
HydromorphoneThe risk or severity of adverse effects can be increased when Hydromorphone is combined with Propoxycaine.Approved, Illicit
IloperidoneThe risk or severity of adverse effects can be increased when Iloperidone is combined with Propoxycaine.Approved
ImipramineThe risk or severity of adverse effects can be increased when Imipramine is combined with Propoxycaine.Approved
IndalpineThe risk or severity of adverse effects can be increased when Propoxycaine is combined with Indalpine.Investigational, Withdrawn
IndiplonThe risk or severity of adverse effects can be increased when Propoxycaine is combined with Indiplon.Investigational
IsofluraneThe risk or severity of adverse effects can be increased when Isoflurane is combined with Propoxycaine.Approved, Vet Approved
KetamineThe risk or severity of adverse effects can be increased when Ketamine is combined with Propoxycaine.Approved, Vet Approved
KetazolamThe risk or severity of adverse effects can be increased when Ketazolam is combined with Propoxycaine.Approved
KetobemidoneThe risk or severity of adverse effects can be increased when Ketobemidone is combined with Propoxycaine.Approved, Investigational
LevobupivacaineThe risk or severity of adverse effects can be increased when Levobupivacaine is combined with Propoxycaine.Approved, Investigational
LevocabastineThe risk or severity of adverse effects can be increased when Propoxycaine is combined with Levocabastine.Approved, Investigational
LevocetirizineThe risk or severity of adverse effects can be increased when Levocetirizine is combined with Propoxycaine.Approved
Levomethadyl AcetateThe risk or severity of adverse effects can be increased when Levomethadyl Acetate is combined with Propoxycaine.Approved, Investigational
LevomilnacipranThe risk or severity of adverse effects can be increased when Propoxycaine is combined with Levomilnacipran.Approved, Investigational
LevorphanolThe risk or severity of adverse effects can be increased when Levorphanol is combined with Propoxycaine.Approved
Lithium cationThe risk or severity of adverse effects can be increased when Lithium is combined with Propoxycaine.Experimental
LofentanilThe risk or severity of adverse effects can be increased when Lofentanil is combined with Propoxycaine.Illicit
LofexidineThe therapeutic efficacy of Propoxycaine can be increased when used in combination with Lofexidine.Approved, Investigational
LoprazolamThe risk or severity of adverse effects can be increased when Propoxycaine is combined with Loprazolam.Experimental
LorazepamThe risk or severity of adverse effects can be increased when Lorazepam is combined with Propoxycaine.Approved
LormetazepamThe risk or severity of adverse effects can be increased when Propoxycaine is combined with Lormetazepam.Approved
LoxapineThe risk or severity of adverse effects can be increased when Loxapine is combined with Propoxycaine.Approved
LurasidoneThe risk or severity of adverse effects can be increased when Lurasidone is combined with Propoxycaine.Approved, Investigational
MaprotilineThe risk or severity of adverse effects can be increased when Maprotiline is combined with Propoxycaine.Approved, Investigational
MebicarThe risk or severity of adverse effects can be increased when Propoxycaine is combined with Mebicar.Experimental
MedazepamThe risk or severity of adverse effects can be increased when Propoxycaine is combined with Medazepam.Experimental
MedetomidineThe risk or severity of adverse effects can be increased when Propoxycaine is combined with Medetomidine.Vet Approved
MelatoninThe risk or severity of adverse effects can be increased when Melatonin is combined with Propoxycaine.Approved, Nutraceutical, Vet Approved
MelperoneThe risk or severity of adverse effects can be increased when Melperone is combined with Propoxycaine.Approved, Investigational
MepivacaineThe risk or severity of adverse effects can be increased when Mepivacaine is combined with Propoxycaine.Approved, Vet Approved
MeprobamateThe risk or severity of adverse effects can be increased when Meprobamate is combined with Propoxycaine.Approved, Illicit
MeptazinolThe risk or severity of adverse effects can be increased when Propoxycaine is combined with Meptazinol.Experimental
MesoridazineThe risk or severity of adverse effects can be increased when Mesoridazine is combined with Propoxycaine.Approved, Investigational
MetaxaloneThe risk or severity of adverse effects can be increased when Metaxalone is combined with Propoxycaine.Approved
MethadoneThe risk or severity of adverse effects can be increased when Methadone is combined with Propoxycaine.Approved
Methadyl AcetateThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Propoxycaine.Approved, Illicit
MethapyrileneThe risk or severity of adverse effects can be increased when Methapyrilene is combined with Propoxycaine.Withdrawn
MethaqualoneThe risk or severity of adverse effects can be increased when Methaqualone is combined with Propoxycaine.Illicit, Withdrawn
MethocarbamolThe risk or severity of adverse effects can be increased when Methocarbamol is combined with Propoxycaine.Approved, Vet Approved
MethohexitalThe risk or severity of adverse effects can be increased when Methohexital is combined with Propoxycaine.Approved
MethotrimeprazinePropoxycaine may increase the central nervous system depressant (CNS depressant) activities of Methotrimeprazine.Approved, Investigational
MethoxyfluraneThe risk or severity of adverse effects can be increased when Methoxyflurane is combined with Propoxycaine.Approved, Investigational, Vet Approved
MethylecgonineThe risk or severity of adverse effects can be increased when Methylecgonine is combined with Propoxycaine.Experimental
MethylphenobarbitalThe risk or severity of adverse effects can be increased when Methylphenobarbital is combined with Propoxycaine.Approved
MetyrosinePropoxycaine may increase the sedative activities of Metyrosine.Approved
MidazolamThe risk or severity of adverse effects can be increased when Midazolam is combined with Propoxycaine.Approved, Illicit
MilnacipranThe risk or severity of adverse effects can be increased when Propoxycaine is combined with Milnacipran.Approved, Investigational
MinocyclineMinocycline may increase the central nervous system depressant (CNS depressant) activities of Propoxycaine.Approved, Investigational
MirtazapinePropoxycaine may increase the central nervous system depressant (CNS depressant) activities of Mirtazapine.Approved
MolindoneThe risk or severity of adverse effects can be increased when Molindone is combined with Propoxycaine.Approved
MorphineThe risk or severity of adverse effects can be increased when Morphine is combined with Propoxycaine.Approved, Investigational
NabiloneNabilone may increase the central nervous system depressant (CNS depressant) activities of Propoxycaine.Approved, Investigational
NalbuphineThe risk or severity of adverse effects can be increased when Nalbuphine is combined with Propoxycaine.Approved
NefazodoneThe risk or severity of adverse effects can be increased when Propoxycaine is combined with Nefazodone.Approved, Withdrawn
NitrazepamThe risk or severity of adverse effects can be increased when Nitrazepam is combined with Propoxycaine.Approved
Nitrous oxideThe risk or severity of adverse effects can be increased when Nitrous oxide is combined with Propoxycaine.Approved, Vet Approved
NordazepamThe risk or severity of adverse effects can be increased when Propoxycaine is combined with Nordazepam.Approved
NorfluraneThe risk or severity of adverse effects can be increased when Propoxycaine is combined with Norflurane.Approved, Investigational
NormethadoneThe risk or severity of adverse effects can be increased when Propoxycaine is combined with Normethadone.Approved, Illicit
NortriptylineThe risk or severity of adverse effects can be increased when Nortriptyline is combined with Propoxycaine.Approved
OlanzapineThe risk or severity of adverse effects can be increased when Olanzapine is combined with Propoxycaine.Approved, Investigational
OlopatadineThe risk or severity of adverse effects can be increased when Olopatadine is combined with Propoxycaine.Approved
OpiumThe risk or severity of adverse effects can be increased when Propoxycaine is combined with Opium.Approved, Illicit
OrphenadrinePropoxycaine may increase the central nervous system depressant (CNS depressant) activities of Orphenadrine.Approved
OsanetantThe risk or severity of adverse effects can be increased when Osanetant is combined with Propoxycaine.Investigational
OxazepamThe risk or severity of adverse effects can be increased when Oxazepam is combined with Propoxycaine.Approved
OxprenololThe risk or severity of adverse effects can be increased when Oxprenolol is combined with Propoxycaine.Approved
OxybuprocaineThe risk or severity of adverse effects can be increased when Oxybuprocaine is combined with Propoxycaine.Approved, Investigational
PaliperidoneThe risk or severity of adverse effects can be increased when Paliperidone is combined with Propoxycaine.Approved
ParaldehydePropoxycaine may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.Approved, Investigational
PentazocineThe risk or severity of adverse effects can be increased when Pentazocine is combined with Propoxycaine.Approved, Vet Approved
PentobarbitalThe risk or severity of adverse effects can be increased when Pentobarbital is combined with Propoxycaine.Approved, Investigational, Vet Approved
PerampanelPerampanel may increase the central nervous system depressant (CNS depressant) activities of Propoxycaine.Approved
PerazineThe risk or severity of adverse effects can be increased when Propoxycaine is combined with Perazine.Approved, Investigational
PerospironeThe risk or severity of adverse effects can be increased when Perospirone is combined with Propoxycaine.Approved
PerphenazineThe risk or severity of adverse effects can be increased when Perphenazine is combined with Propoxycaine.Approved
PethidineThe risk or severity of adverse effects can be increased when Pethidine is combined with Propoxycaine.Approved
PhenazocineThe risk or severity of adverse effects can be increased when Propoxycaine is combined with Phenazocine.Experimental
PhenibutThe risk or severity of adverse effects can be increased when Propoxycaine is combined with Phenibut.Experimental
PhenoperidineThe risk or severity of adverse effects can be increased when Propoxycaine is combined with Phenoperidine.Experimental
PhenoxyethanolThe risk or severity of adverse effects can be increased when Propoxycaine is combined with Phenoxyethanol.Approved
PhenytoinThe risk or severity of adverse effects can be increased when Phenytoin is combined with Propoxycaine.Approved, Vet Approved
PimozideThe risk or severity of adverse effects can be increased when Pimozide is combined with Propoxycaine.Approved
PipamperoneThe risk or severity of adverse effects can be increased when Pipamperone is combined with Propoxycaine.Approved, Investigational
PipotiazineThe risk or severity of adverse effects can be increased when Pipotiazine is combined with Propoxycaine.Approved, Investigational
PiritramideThe risk or severity of adverse effects can be increased when Propoxycaine is combined with Piritramide.Approved, Investigational
PizotifenThe risk or severity of adverse effects can be increased when Pizotifen is combined with Propoxycaine.Approved
PomalidomideThe risk or severity of adverse effects can be increased when Pomalidomide is combined with Propoxycaine.Approved
PrazepamThe risk or severity of adverse effects can be increased when Prazepam is combined with Propoxycaine.Approved, Illicit
PrilocaineThe risk or severity of adverse effects can be increased when Prilocaine is combined with Propoxycaine.Approved
PrimidoneThe risk or severity of adverse effects can be increased when Primidone is combined with Propoxycaine.Approved, Vet Approved
ProcaineThe risk or severity of adverse effects can be increased when Procaine is combined with Propoxycaine.Approved, Investigational, Vet Approved
PromazineThe risk or severity of adverse effects can be increased when Promazine is combined with Propoxycaine.Approved, Vet Approved
PropanididThe risk or severity of adverse effects can be increased when Propoxycaine is combined with Propanidid.Experimental
ProparacaineThe risk or severity of adverse effects can be increased when Proparacaine is combined with Propoxycaine.Approved, Vet Approved
PropofolThe risk or severity of adverse effects can be increased when Propofol is combined with Propoxycaine.Approved, Investigational, Vet Approved
ProtriptylineThe risk or severity of adverse effects can be increased when Protriptyline is combined with Propoxycaine.Approved
ProxibarbalThe risk or severity of adverse effects can be increased when Propoxycaine is combined with Proxibarbal.Experimental
PSD502The risk or severity of adverse effects can be increased when PSD502 is combined with Propoxycaine.Investigational
QuazepamThe risk or severity of adverse effects can be increased when Quazepam is combined with Propoxycaine.Approved, Illicit
QuinisocaineThe risk or severity of adverse effects can be increased when Propoxycaine is combined with Quinisocaine.Experimental
RacloprideThe risk or severity of adverse effects can be increased when Propoxycaine is combined with Raclopride.Investigational
RamelteonThe risk or severity of adverse effects can be increased when Ramelteon is combined with Propoxycaine.Approved, Investigational
RemifentanilThe risk or severity of adverse effects can be increased when Remifentanil is combined with Propoxycaine.Approved
RemoxiprideThe risk or severity of adverse effects can be increased when Remoxipride is combined with Propoxycaine.Approved, Withdrawn
ReserpineThe risk or severity of adverse effects can be increased when Reserpine is combined with Propoxycaine.Approved, Investigational
RisperidoneThe risk or severity of adverse effects can be increased when Risperidone is combined with Propoxycaine.Approved, Investigational
RitanserinThe risk or severity of adverse effects can be increased when Propoxycaine is combined with Ritanserin.Investigational
RomifidineThe risk or severity of adverse effects can be increased when Propoxycaine is combined with Romifidine.Vet Approved
RopivacaineThe risk or severity of adverse effects can be increased when Ropivacaine is combined with Propoxycaine.Approved
RotigotinePropoxycaine may increase the sedative activities of Rotigotine.Approved
RufinamideThe risk or severity of adverse effects can be increased when Rufinamide is combined with Propoxycaine.Approved
SecobarbitalThe risk or severity of adverse effects can be increased when Secobarbital is combined with Propoxycaine.Approved, Vet Approved
SepranoloneThe risk or severity of adverse effects can be increased when Propoxycaine is combined with Sepranolone.Investigational
SertindoleThe risk or severity of adverse effects can be increased when Sertindole is combined with Propoxycaine.Approved, Investigational, Withdrawn
SertralineThe risk or severity of adverse effects can be increased when Propoxycaine is combined with Sertraline.Approved
SevofluraneThe risk or severity of adverse effects can be increased when Sevoflurane is combined with Propoxycaine.Approved, Vet Approved
Sodium oxybateSodium oxybate may increase the central nervous system depressant (CNS depressant) activities of Propoxycaine.Approved
StiripentolThe risk or severity of adverse effects can be increased when Stiripentol is combined with Propoxycaine.Approved
SufentanilThe risk or severity of adverse effects can be increased when Sufentanil is combined with Propoxycaine.Approved, Investigational
SulpirideThe risk or severity of adverse effects can be increased when Sulpiride is combined with Propoxycaine.Approved, Investigational
SultoprideThe risk or severity of adverse effects can be increased when Propoxycaine is combined with Sultopride.Experimental
SuvorexantPropoxycaine may increase the central nervous system depressant (CNS depressant) activities of Suvorexant.Approved, Investigational
TandospironeThe risk or severity of adverse effects can be increased when Propoxycaine is combined with Tandospirone.Investigational
TapentadolTapentadol may increase the central nervous system depressant (CNS depressant) activities of Propoxycaine.Approved
TasimelteonThe risk or severity of adverse effects can be increased when Tasimelteon is combined with Propoxycaine.Approved, Investigational
Technetium Tc-99m tilmanoceptPropoxycaine may decrease effectiveness of Technetium Tc-99m tilmanocept as a diagnostic agent.Approved, Investigational
TemazepamThe risk or severity of adverse effects can be increased when Temazepam is combined with Propoxycaine.Approved, Investigational
TetrabenazineThe risk or severity of adverse effects can be increased when Tetrabenazine is combined with Propoxycaine.Approved, Investigational
TetracaineThe risk or severity of adverse effects can be increased when Tetracaine is combined with Propoxycaine.Approved, Vet Approved
TetrodotoxinThe risk or severity of adverse effects can be increased when Tetrodotoxin is combined with Propoxycaine.Investigational
ThalidomidePropoxycaine may increase the central nervous system depressant (CNS depressant) activities of Thalidomide.Approved, Investigational, Withdrawn
ThiamylalThe risk or severity of adverse effects can be increased when Thiamylal is combined with Propoxycaine.Approved, Vet Approved
ThiopentalThe risk or severity of adverse effects can be increased when Thiopental is combined with Propoxycaine.Approved, Vet Approved
ThioridazineThe risk or severity of adverse effects can be increased when Thioridazine is combined with Propoxycaine.Approved, Withdrawn
ThiothixeneThe risk or severity of adverse effects can be increased when Thiothixene is combined with Propoxycaine.Approved
TiagabineThe risk or severity of adverse effects can be increased when Tiagabine is combined with Propoxycaine.Approved, Investigational
TiaprideThe risk or severity of adverse effects can be increased when Propoxycaine is combined with Tiapride.Approved, Investigational
TiletamineThe risk or severity of adverse effects can be increased when Propoxycaine is combined with Tiletamine.Vet Approved
TilidineThe risk or severity of adverse effects can be increased when Propoxycaine is combined with Tilidine.Experimental
TizanidineThe risk or severity of adverse effects can be increased when Tizanidine is combined with Propoxycaine.Approved, Investigational
TolcaponeThe risk or severity of adverse effects can be increased when Tolcapone is combined with Propoxycaine.Approved, Withdrawn
TranylcypromineThe risk or severity of adverse effects can be increased when Tranylcypromine is combined with Propoxycaine.Approved, Investigational
TrazodoneThe risk or severity of adverse effects can be increased when Trazodone is combined with Propoxycaine.Approved, Investigational
TriazolamThe risk or severity of adverse effects can be increased when Triazolam is combined with Propoxycaine.Approved, Investigational
Tricaine methanesulfonateThe risk or severity of adverse effects can be increased when Propoxycaine is combined with Tricaine methanesulfonate.Vet Approved
TrichloroethyleneThe risk or severity of adverse effects can be increased when Propoxycaine is combined with Trichloroethylene.Approved
TrifluoperazineThe risk or severity of adverse effects can be increased when Trifluoperazine is combined with Propoxycaine.Approved, Investigational
TrifluperidolThe risk or severity of adverse effects can be increased when Propoxycaine is combined with Trifluperidol.Experimental
TriflupromazineThe risk or severity of adverse effects can be increased when Triflupromazine is combined with Propoxycaine.Approved, Vet Approved
TrimipramineThe risk or severity of adverse effects can be increased when Trimipramine is combined with Propoxycaine.Approved
TriprolidineThe risk or severity of adverse effects can be increased when Triprolidine is combined with Propoxycaine.Approved
VeraliprideThe risk or severity of adverse effects can be increased when Propoxycaine is combined with Veralipride.Experimental
VigabatrinThe risk or severity of adverse effects can be increased when Vigabatrin is combined with Propoxycaine.Approved
Vinyl etherThe risk or severity of adverse effects can be increased when Propoxycaine is combined with Vinyl ether.Experimental
VortioxetineThe risk or severity of adverse effects can be increased when Vortioxetine is combined with Propoxycaine.Approved, Investigational
XenonThe risk or severity of adverse effects can be increased when Propoxycaine is combined with Xenon.Experimental
XylazineThe risk or severity of adverse effects can be increased when Propoxycaine is combined with Xylazine.Vet Approved
ZaleplonThe risk or severity of adverse effects can be increased when Zaleplon is combined with Propoxycaine.Approved, Illicit, Investigational
ZimelidineThe risk or severity of adverse effects can be increased when Propoxycaine is combined with Zimelidine.Withdrawn
ZiprasidoneThe risk or severity of adverse effects can be increased when Ziprasidone is combined with Propoxycaine.Approved
ZolazepamThe risk or severity of adverse effects can be increased when Propoxycaine is combined with Zolazepam.Vet Approved
ZopicloneThe risk or severity of adverse effects can be increased when Zopiclone is combined with Propoxycaine.Approved
ZotepineThe risk or severity of adverse effects can be increased when Zotepine is combined with Propoxycaine.Approved, Investigational, Withdrawn
ZuclopenthixolThe risk or severity of adverse effects can be increased when Zuclopenthixol is combined with Propoxycaine.Approved, Investigational
Food Interactions
Not Available

References

General References
  1. Hung CH, Liu KS, Shao DZ, Cheng KI, Chen YC, Chen YW: The systemic toxicity of equipotent proxymetacaine, oxybuprocaine, and bupivacaine during continuous intravenous infusion in rats. Anesth Analg. 2010 Jan 1;110(1):238-42. doi: 10.1213/ANE.0b013e3181bf6acf. Epub 2009 Nov 6. [PubMed:19897799]
  2. Lee JH, Kim DI, Mun H, Lee SK, Park JS, Kim JH, Lee JH, Park YH, Jeon YC, Yoon UC, Bae MK, Jang HO, Wood WG, Yun I: The effect of propoxycaine.HCl on the physical properties of neuronal membranes. Chem Phys Lipids. 2008 Jul;154(1):19-25. doi: 10.1016/j.chemphyslip.2008.03.009. Epub 2008 Mar 22. [PubMed:18407836]
  3. PROPOXYCAINE [Link]
  4. New local anesthetic solutions containing propoxycaine [Link]
  5. Handbook of Dental Anesthesia- Ebook [Link]
  6. Essentials of local anesthetic pharmacology [Link]
  7. Propoxycaine Hydrochloride [Link]
External Links
KEGG Compound
C07895
PubChem Compound
6843
PubChem Substance
310265217
ChemSpider
6582
ChEBI
8496
ChEMBL
CHEMBL1195
Wikipedia
Propoxycaine

Clinical Trials

Clinical Trials
Not Available

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage forms
Not Available
Prices
Not Available
Patents
Not Available

Properties

State
Solid
Experimental Properties
PropertyValueSource
melting point (°C)146-151http://www.pharmacopeia.cn/v29240/usp29nf24s0_m70480.html
water solubility10 µg/mL in waterhttp://www.pharmacopeia.cn/v29240/usp29nf24s0_m70480.html
Predicted Properties
PropertyValueSource
Water Solubility1.79 mg/mLALOGPS
logP2.89ALOGPS
logP2.6ChemAxon
logS-2.2ALOGPS
pKa (Strongest Basic)8.96ChemAxon
Physiological Charge1ChemAxon
Hydrogen Acceptor Count4ChemAxon
Hydrogen Donor Count1ChemAxon
Polar Surface Area64.79 Å2ChemAxon
Rotatable Bond Count10ChemAxon
Refractivity86.04 m3·mol-1ChemAxon
Polarizability34.2 Å3ChemAxon
Number of Rings1ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleNoChemAxon
MDDR-like RuleNoChemAxon
Predicted ADMET features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
SpectrumSpectrum TypeSplash Key
Predicted GC-MS Spectrum - GC-MSPredicted GC-MSNot Available
Predicted MS/MS Spectrum - 10V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 20V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 40V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 10V, Negative (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 20V, Negative (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 40V, Negative (Annotated)Predicted LC-MS/MSNot Available

Taxonomy

Description
This compound belongs to the class of organic compounds known as benzoic acid esters. These are ester derivatives of benzoic acid.
Kingdom
Organic compounds
Super Class
Benzenoids
Class
Benzene and substituted derivatives
Sub Class
Benzoic acids and derivatives
Direct Parent
Benzoic acid esters
Alternative Parents
Aminobenzoic acids and derivatives / Aminophenyl ethers / Phenoxy compounds / Benzoyl derivatives / Aniline and substituted anilines / Alkyl aryl ethers / Trialkylamines / Carboxylic acid esters / Amino acids and derivatives / Monocarboxylic acids and derivatives
show 4 more
Substituents
Aminobenzoic acid or derivatives / Benzoate ester / Aminophenyl ether / Phenoxy compound / Benzoyl / Aniline or substituted anilines / Phenol ether / Alkyl aryl ether / Amino acid or derivatives / Tertiary aliphatic amine
show 15 more
Molecular Framework
Aromatic homomonocyclic compounds
External Descriptors
benzoate ester (CHEBI:8496)

Targets

1. Voltage gated sodium channel
Kind
Protein group
Organism
human
Pharmacological action
Unknown
Actions
Antagonist
References
  1. PROPOXYCAINE [Link]

Enzymes

Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Substrate
General Function
Triglyceride lipase activity
Specific Function
Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs. Hydrolyzes aromatic and aliphatic esters, but has no catalytic activity toward amides or a fatty acy...
Gene Name
CES1
Uniprot ID
P23141
Uniprot Name
Liver carboxylesterase 1
Molecular Weight
62520.62 Da
References
  1. Handbook of Dental Anesthesia- Ebook [Link]

Drug created on November 27, 2015 13:23 / Updated on August 02, 2018 07:52