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Displaying drugs 551 - 575 of 15294 in total
Ceritinib is used for the treatment of adults with anaplastic lymphoma kinase (ALK)-positive metastatic non-small cell lung cancer (NSCLC) following failure (secondary to resistance or intolerance) of prior crizotinib therapy. About 4% of patients with NSCLC have a chromosomal rearrangement that generates a fusion gene between EML4 (echinoderm microtubule-associated protein-like...
Approved
Matched Synonyms: … N-{2-[(5-chloro-2-{[2-isopropoxy-5-methyl-4-(piperidin-4-yl)phenyl]amino}pyrimidin-4-yl)amino]phenyl} ... propane-2-sulfonamide …
Matched Iupac: … 5-chloro-N2-[5-methyl-4-(piperidin-4-yl)-2-(propan-2-yloxy)phenyl]-N4-[2-(propane-2-sulfonyl)phenyl]pyrimidine …
Matched Description: … The FDA approved ceritinib in April 2014 due to a surprisingly high response rate (56%) towards crizotinib-resistant ... Ceritinib is used for the treatment of adults with anaplastic lymphoma kinase (ALK)-positive metastatic ... About 4% of patients with NSCLC have a chromosomal rearrangement that generates a fusion gene between …
Matched Categories: … P-glycoprotein substrates with a Narrow Therapeutic Index ... Cytochrome P-450 CYP3A4 Substrates with a Narrow Therapeutic Index …
Carfilzomib is an injectable antineoplastic agent (IV only). Chemically, it is a modified tetrapeptidyl epoxide and an analog of epoxomicin. It is also a selective proteasome inhibitor. FDA approved carfilzomib in July 2012 for the treatment of adults with relapsed or refractory multiple myeloma as monotherapy or combination therapy.
Approved
Investigational
Matched Iupac: … (2S)-4-methyl-N-[(1S)-1-{[(2S)-4-methyl-1-[(2R)-2-methyloxiran-2-yl]-1-oxopentan-2-yl]carbamoyl}-2-phenylethyl ... ]-2-[(2S)-2-[2-(morpholin-4-yl)acetamido]-4-phenylbutanamido]pentanamide …
Matched Description: … FDA approved carfilzomib in July 2012 for the treatment of adults with relapsed or refractory multiple ... It is also a selective proteasome inhibitor. ... Chemically, it is a modified tetrapeptidyl epoxide and an analog of epoxomicin. …
Matched Categories: … P-glycoprotein substrates with a Narrow Therapeutic Index …
Matched Products: … KYPROLIS POWDER FOR SOLUTION FOR INFUSION 60MG/VIAL ... KYPROLIS POWDER FOR SOLUTION FOR INFUSION 30 MG/VIAL ... Kyprolis (carfilzomib) powder for solution for infusion 60mg/vial …
A seasonally-specific component of the influenza vaccine. The influenza vaccine, also known as the "flu shot", is a vaccine that protects against infection from the influenza viruses. Vaccines provide protection from influenza by exposing the immune system to the virus (or parts of the virus) which stimulates an immunological defence...
Approved
Matched Synonyms: … Influenza a Virus H1n1 Live Antigen, A ... Influenza a Virus A/south Dakota/6/2007 (H1n1) Live(attenuated) Antigen ... Influenza a Virus A/south Dakota/6/2007(h1n1) Live(attenuated) Antigen …
Matched Name: … Influenza A virus A/South Dakota/6/2007 (H1N1) live (attenuated) antigen …
Matched Description: … Inactivated vaccines contain a virus particle that has been grown in media and then subsequently killed ... , or inactivated, through exposure to heat or chemicals such as formaldehyde 3. ... A seasonally-specific component of the influenza vaccine. …
A pyrazine that is used therapeutically as an antitubercular agent.
Approved
Investigational
Matched Synonyms: … 2-carbamylpyrazine ... 2-pyrazinecarboxamide ... pyrazine-2-carboxamide …
Matched Iupac: … pyrazine-2-carboxamide …
Matched Description: … A pyrazine that is used therapeutically as an antitubercular agent. …
Matched Mixtures name: … PRO TB 3 KID ... RINCURE ® 3 FDC TABLETAS CON PELICULA …
Matched Categories: … Antiinfectives for Systemic Use ... Drugs for Treatment of Tuberculosis …
Docetaxel is a clinically well established anti-mitotic chemotherapy medication used for the treatment of different types of cancer, including breast, ovarian, and non-small cell lung cancer. Docetaxel is a complex diterpenoid molecule and a semisynthetic analogue of paclitaxel.[A259676,L46466] Docetaxel reversibly binds to microtubulin with high affinity in a 1:1 stoichiometric...
Approved
Investigational
Matched Iupac: … (1S,2S,3R,4S,7R,9S,10S,12R,15S)-4-(acetyloxy)-15-{[(2R,3S)-3-{[(tert-butoxy)carbonyl]amino}-2-hydroxy ... }.0^{4,7}]heptadec-13-en-2-yl benzoate ... -3-phenylpropanoyl]oxy}-1,9,12-trihydroxy-10,14,17,17-tetramethyl-11-oxo-6-oxatetracyclo[11.3.1.0^{3,10 …
Matched Description: … [L46466] Docetaxel was approved by the FDA in 1996 and is available in solution for injection for intravenous ... Docetaxel is a clinically well established anti-mitotic chemotherapy medication used for the treatment ... [A259676,L46466] Docetaxel reversibly binds to microtubulin with high affinity in a 1:1 stoichiometric …
Matched Categories: … P-glycoprotein substrates with a Narrow Therapeutic Index ... Cytochrome P-450 CYP3A4 Substrates with a Narrow Therapeutic Index ... Cytochrome P-450 CYP3A5 Substrates with a Narrow Therapeutic Index ... Cytochrome P-450 CYP3A7 Substrates with a Narrow Therapeutic Index …
Matched Products: … DOCETAXEL DONG-A ... Hospira Docetaxel Concentrate for Solution for Infusion 20 mg / 2 ml ... TAXESPIRA® 20 MG / 2 ML …
Artemether is an antimalarial agent used to treat acute uncomplicated malaria. It is administered in combination with lumefantrine for improved efficacy. This combination therapy exerts its effects against the erythrocytic stages of Plasmodium spp. and may be used to treat infections caused by P. falciparum and unidentified Plasmodium species, including...
Approved
Matched Description: … It is administered in combination with lumefantrine for improved efficacy. ... caused by P. falciparum and unidentified Plasmodium species, including infections acquired in
A clear, colorless, viscous organic solvent and diluent used in pharmaceutical preparations.
Approved
Investigational
Matched Synonyms: … 2-hydroxypropanol …
Matched Description: … A clear, colorless, viscous organic solvent and diluent used in pharmaceutical preparations. …
Matched Categories: … Compounds used in a research, industrial, or household setting …
Crotalus scutulatus antivenin is derived and purified immunoglobulin fragments obtained from other domestic animals such as sheep previously immunized with Crotalus scutulatus (also known as the Mojave rattlesnake ). The final purified antivenin product is obtained by mixing other different monospecific snake antivenins and isolating the antivenin of interest through...
Approved
Experimental
Matched Description: … CROFAB (crotalidae polyvalent immune fab (ovine))is a sheep-derived antivenin used for the management ... Specimens with type A venom, which cause a different pattern of injury than other rattlesnakes, have ... been reported in southern California, Nevada, Utah, Arizona, Texas, and New Mexico [L2856]. …
alpha-Amyl cinnamaldehyde has a jasmine-like odor and is a widely used synthetic fragrance & suspected allergen. It is used in allergenic testing.
Approved
Experimental
Matched Synonyms: … 2-Pentylcinnamaldehyde ... 2-(Phenylmethylene)heptanal …
Matched Iupac: … (2Z)-2-(phenylmethylidene)heptanal …
Matched Description: … It is used in allergenic testing. ... alpha-Amyl cinnamaldehyde has a jasmine-like odor and is a widely used synthetic fragrance & suspected …
Isavuconazole is an triazole antifungal with broad spectrum of activity and good safety profile . It is approved by the FDA and EMA for the treatment of invasive aspergillosis and mucormycosis. It works by inhibiting fungal cell membrane synthesis. Invasive fungal infections pose significant clinical challenges for patients, especially those...
Approved
Investigational
Matched Iupac: … 4-{2-[(2R,3R)-3-(2,5-difluorophenyl)-3-hydroxy-4-(1H-1,2,4-triazol-1-yl)butan-2-yl]-1,3-thiazol-4-yl} …
Matched Description: … facilitating drug solubility; this is because cyclodextrin has a potential for nephrotoxicity [A32029 ... a repeat loading dose when transitioning from an IV to an oral formulation [A32026]. ... In vitro, most of the _Candida_ species, most _Aspergillus_ species, Mucorales, _Cryptococcus_ spp., …
Matched Categories: … Antimycotics for Systemic Use ... Antiinfectives for Systemic Use …
Matched Products: … CRESEMBA (POWDER FOR SOLUTION FOR CONCENTRATE FOR SOLUTION FOR INFUSION 200 MG/VIAL) …
Letermovir recieved approval from the FDA on November 8th, 2017 for use in prophylaxis of cytomegalovirus (CMV) infection in allogeneic hematopoietic stem cell transplant patients. It is the first of a new class of CMV anti-infectives called DNA terminase complex inhibitors. Letermovir has recieved both priority and orphan drug status...
Approved
Investigational
Matched Iupac: … 2-[(4S)-8-fluoro-3-[2-methoxy-5-(trifluoromethyl)phenyl]-2-[4-(3-methoxyphenyl)piperazin-1-yl]-3,4-dihydroquinazolin …
Matched Description: … Letermovir recieved approval from the FDA on November 8th, 2017 for use in prophylaxis of cytomegalovirus ... [L1021] It is the first of a new class of CMV anti-infectives called DNA terminase complex inhibitors ... (CMV) infection in allogeneic hematopoietic stem cell transplant patients. …
Matched Categories: … Heterocyclic Compounds, 2-Ring ... Antivirals for Systemic Use ... Antiinfectives for Systemic Use …
Matched Products: … PREVYMIS CONCENTRATE FOR SOLUTION FOR INFUSION 20MG/ML ... PREVYMIS 240mg/12mL (20mg/mL) concentrate for solution for infusion ... PREVYMIS 480mg/24mL (20mg/mL) concentrate for solution for infusion …
Asparaginase derived from Escherichia coli (L-asparagine amidohydrolase, EC 3.5.1.1) is an enzyme responsible for the metabolism of L-asparagine, by catalyzing L-asparagine into L-aspartic acid and ammonia. It also facilitates the production of oxaloacetate which is needed for general cellular metabolism. Asparaginase from E. coli has clinically shown to exhibit antitumor...
Approved
Investigational
Matched Synonyms: … Asparaginase (E. coli) …
Matched Description: … treatment of acute lymphoblastic leukemia (ALL) as part of a multi-agent chemotherapeutic regimen. ... Therapeutic L-asparaginase from _E. coli_ works by depleting the levels of non-essential amino acid, ... asparagine, in lymphoblastic leukemic cells thus promoting apoptotic cell death [A31999]. …
Matched Products: … LEUNASE FOR INJECTION 10,000 iu/vial …
Eugenol is a naturally occurring phenolic molecule found in several plants such as cinnamon, clove, and bay leaves. It has been used as a topical antiseptic as a counter-irritant and in dental preparations with zinc oxide for root canal sealing and pain control. Although not currently available in any FDA-approved...
Approved
Matched Iupac: … 2-methoxy-4-(prop-2-en-1-yl)phenol …
Matched Description: … It has been used as a topical antiseptic as a counter-irritant and in dental preparations with zinc oxide ... There are a number of unapproved OTC products available containing eugenol that advertise its use for ... Eugenol is a naturally occurring phenolic molecule found in several plants such as cinnamon, clove, and …
Matched Categories: … Compounds used in a research, industrial, or household setting …
Matched Products: … Orajel Naturals FAst Relief for Teething Pain ... Baby Orajel Naturals Remedy for Teething Pain Relief …
Ferric pyrophosphate citrate is a soluble iron replacement product. Free iron presents several side effects as it can catalyze free radical formation and lipid peroxidation as well as the presence of interactions of iron in plasma. The ferric ion is strongly complexed by pyrophosphate and citrate. FPC is categorized in...
Approved
Investigational
Matched Iupac: … tetrairon(3+) bis((phosphonooxy)phosphonic acid) tris(2-hydroxypropane-1,2,3-tricarboxylate) (hydrogen …
Matched Description: … [A31979] FPC is categorized in Japan as a second class OTC drug. ... Ferric pyrophosphate citrate is a soluble iron replacement product. ... catalyze free radical formation and lipid peroxidation as well as the presence of interactions of iron in
Matched Products: … Triferic Solution for Hemodialysis …
Technetium 99m sulfur colloid is a radiopharmaceutical diagnostic agent used in the evaluation of various conditions including lymph node metastases in breast cancer, detection of shunt patency, imaging of reticuloendothelial cells for assessment of liver function, and studies of esophageal transit and gastroesophageal reflux. Following injection or oral administration, single...
Approved
Investigational
Matched Description: … Technetium 99m sulfur colloid is a radiopharmaceutical diagnostic agent used in the evaluation of various ... reticuloendothelial cells for assessment of liver function, and studies of esophageal transit and gastroesophageal ... conditions including lymph node metastases in breast cancer, detection of shunt patency, imaging of …
Matched Categories: … Compounds used in a research, industrial, or household setting …
Matched Products: … Kit for the Prepartion of Technetium Tc99m Sulfur Colloid ... Kit for the Preparation of Technetium Tc 99m Sulfur Colloid …
Salbutamol (Albuterol [USAN]) is a short-acting, selective beta2-adrenergic receptor agonist used in the treatment of asthma and COPD. It is 29 times more selective for beta2 receptors than beta1 receptors giving it higher specificity for pulmonary beta receptors versus beta1-adrenergic receptors located in the heart. Salbutamol is formulated as a...
Approved
Vet approved
Matched Iupac: … 4-[2-(tert-butylamino)-1-hydroxyethyl]-2-(hydroxymethyl)phenol …
Matched Description: … Salbutamol (Albuterol [USAN]) is a short-acting, selective beta2-adrenergic receptor agonist used in ... Salbutamol is formulated as a racemic mixture of the R- and S-isomers. ... pulmonary beta receptors versus beta1-adrenergic receptors located in the heart. …
Matched Mixtures name: … ULAX-C ... SALBUTAMOLO E IPRATROPIO BROMURO EG ... COMBIVENT UNIT DOSE VIAL FOR INHALATION …
Matched Categories: … Drugs for Obstructive Airway Diseases ... Medications that reduce magnesium levels ... Adrenergic beta-2 Receptor Agonists ... Selective Beta 2-adrenergic Agonists …
Matched Products: … Injection 0.5mg Salbutamol In 1 Ml (500mcg/ml) ... VENTOLIN SOLUTION FOR IV INFUSION 1MG/ML ... Bolus Injection 0.25mg Salbutamol In 5ml (50mcg/ml) …
Obinutuzumab is a humanized monoclonal antibody used as a combination treatment with chlorambucil to treat patients with untreated chronic lymphocytic leukemia. It was approved by the FDA in November 2013 and is marketed under the brand name Gazyva. There is a black box warning of fatal Hepatitis B Virus (HBV)...
Approved
Investigational
Matched Description: … It was approved by the FDA in November 2013 and is marketed under the brand name Gazyva. ... Obinutuzumab is a humanized monoclonal antibody used as a combination treatment with chlorambucil to ... There is a black box warning of fatal Hepatitis B Virus (HBV) reactivation and fatal Progressive Multifocal …
Matched Products: … GAZYVA 1000 MG/ 40 ML CONCENTRATE FOR SOLUTION FOR INFUSION ... GAZYVA CONCENTRATE FOR SOLUTION FOR INFUSION 1000MG/40ML …
Baclofen is a gamma-aminobutyric acid (GABA) agonist used as a skeletal muscle relaxant. Although originally designed in 1962 to treat epilepsy, baclofen was not effective in treating this condition but instead was shown to reduce spasticity in selected patients. Baclofen was reintroduced in 1971 as a treatment for spasticity and...
Approved
Matched Synonyms: … 4-Amino-3-(4-chlorophenyl)butyric acid ... DL-4-Amino-3-p-chlorophenylbutanoic acid …
Matched Iupac: … 4-amino-3-(4-chlorophenyl)butanoic acid …
Matched Description: … [A245338] Baclofen was reintroduced in 1971 as a treatment for spasticity and was later approved by the ... [L39429] Baclofen was investigated for use in alcohol dependence and withdrawal; however, evidence ... Baclofen is a gamma-aminobutyric acid (GABA) agonist used as a skeletal muscle relaxant. …
Matched Products: … Baclofen Sintetica 2 mg/ml Intrathekal Infusionslösung …
North American Coral Snake Antivenin (Equine) is a horse-derived antivenin indicated for the treatment of envenomation caused by North American coral snake bites. It is intravenously administered so that the antivenin binds to and neutralizes coral snake venom. The antivenin is a refined, concentrated, and lyophilized preparation of serum globulins...
Approved
Experimental
Matched Description: … North American Coral Snake Antivenin (Equine) is a horse-derived antivenin indicated for the treatment ... The antivenin is a refined, concentrated, and lyophilized preparation of serum globulins obtained by …
A seasonally-specific component of the influenza vaccine. The influenza vaccine, also known as the "flu shot", is a vaccine that protects against infection from the influenza viruses. Vaccines provide protection from influenza by exposing the immune system to the virus (or parts of the virus) which stimulates an immunological defence...
Approved
Matched Description: … Inactivated vaccines contain a virus particle that has been grown in media and then subsequently killed ... , or inactivated, through exposure to heat or chemicals such as formaldehyde 3. ... A seasonally-specific component of the influenza vaccine. …
A complex of related glycopeptide antibiotics from Streptomyces verticillus consisting of bleomycin A2 and B2 (B2 CAS # 9060-10-0). It inhibits DNA metabolism and is used as an antineoplastic, especially for solid tumors. Bleomycin A2 is used as the representative structure for Bleomycin.
Approved
Investigational
Matched Iupac: … (3-{[2-(2-{2-[(2S,3R)-2-[(2S,3S,4R)-4-[(2S,3R)-2-({6-amino-2-[(1S)-1-{[(2S)-2-amino-2-carbamoylethyl] ... amino}-2-carbamoylethyl]-5-methylpyrimidin-4-yl}formamido)-3-[(3-{[4-(carbamoyloxy)-3,5-dihydroxy-6-( ... ]-3-hydroxy-2-methylpentanamido]-3-hydroxybutanamido]ethyl}-1,3-thiazol-4-yl)-1,3-thiazol-4-yl]formamido ... hydroxymethyl)oxan-2-yl]oxy}-4,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl)oxy]-3-(1H-imidazol-4-yl)propanamido …
Matched Description: … A complex of related glycopeptide antibiotics from Streptomyces verticillus consisting of bleomycin ... Bleomycin A2 is used as the representative structure for Bleomycin. ... It inhibits DNA metabolism and is used as an antineoplastic, especially for solid tumors. …
Matched Products: … Bleomycin for Injection ... Bleomycin for Injection USP ... BLOICIN-S FOR INJECTION 15 UNITS …
Avibactam is a non-β-lactam β-lactamase inhibitor that is available in combination with ceftazidime (Avycaz). This combination was approved by the FDA on February 25, 2015 for the treatment of complicated intra-abdominal infections in combination with metronidazole, and the treatment of complicated urinary tract infections, including pyelonephritis caused by antibiotic resistant-pathogens,...
Approved
Matched Iupac: … [(2S,5R)-2-carbamoyl-7-oxo-1,6-diazabicyclo[3.2.1]octan-6-yl]oxidanesulfonic acid …
Matched Description: … Avibactam is a non-β-lactam β-lactamase inhibitor that is available in combination with ceftazidime ( ... infections in combination with metronidazole, and the treatment of complicated urinary tract infections ... As there is limited clinical safety and efficacy data, Avycaz should be reserved for patients over 18 …
Matched Mixtures name: … ZAVİCEFTA 2 G/0.5 G İNFÜZYONLUK ÇÖZELTİ HAZIRLAMAK İÇİN TOZ, 10 ADET …
Matched Products: … ZAVICEFTA POWDER FOR CONCENTRATE FOR SOLUTION FOR INFUSION 2G/0.5G …
Pyrethrum is the crude extract form obtained from flowers of the plant Chrysanthemum cinerariifolium. Pyrethrin refers to a more refined extract of pyrethrum. While pyrethrum extract is composed of 6 esters, both organic compounds mediate insecticidal activities. Pyrethrum-containing mixtures are used as a common insecticide to control specific pest species....
Approved
Matched Description: … Pyrethrin refers to a more refined extract of pyrethrum. ... Pyrethrum-containing mixtures are used as a common insecticide to control specific pest species. …
Matched Mixtures name: … Mata Piojos A Pediculicide Low Foaming ... R & C Shampoo With Conditioner ... CVS 3 Step Lice Solution …
Matched Categories: … Compounds used in a research, industrial, or household setting …
A local anesthetic that is chemically related to bupivacaine but pharmacologically related to lidocaine. It is indicated for infiltration, nerve block, and epidural anesthesia. Mepivacaine is effective topically only in large doses and therefore should not be used by this route. (From AMA Drug Evaluations, 1994, p168)
Approved
Vet approved
Matched Synonyms: … 1-methyl-2',6'-pipecoloxylidide ... (+-)-1-Methyl-2',6'-pipecoloxylidide ... N-(2,6-Dimethylphenyl)-1-methyl-2-piperidinecarboxamide …
Matched Iupac: … N-(2,6-dimethylphenyl)-1-methylpiperidine-2-carboxamide …
Matched Description: … It is indicated for infiltration, nerve block, and epidural anesthesia. ... A local anesthetic that is chemically related to bupivacaine but pharmacologically related to lidocaine ... Mepivacaine is effective topically only in large doses and therefore should not be used by this route …
Matched Mixtures name: … MEPISEAL-E ... Scandonest 2% L ... ODONTOCAINA ® 2% …
Matched Products: … A. T. O. MEPIVACAINE 3% PLAIN. SOLUCION INYECTYABLE ... MEPIVACAINA BONISCONTRO E GAZZONE ... Carbocaine 2% …
An isomer of 1-propanol. It is a colorless liquid having disinfectant properties. It is used in the manufacture of acetone and its derivatives and as a solvent. Topically, it is used as an antiseptic.
Approved
Investigational
Matched Synonyms: … 2-Propanol …
Matched Iupac: … propan-2-ol …
Matched Description: … It is used in the manufacture of acetone and its derivatives and as a solvent. ... It is a colorless liquid having disinfectant properties. …
Matched Mixtures name: … C-tizers 99.9 ... Sooth-a-Sting ... 3เอ็ม ซีเอชจี แพด …
Matched Categories: … Compounds used in a research, industrial, or household setting …
Matched Products: … Alpet E-3 ... Zep Alpet E-3 Sanitizer ... Coghlans Survival In A Can …
Displaying drugs 551 - 575 of 15294 in total