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Displaying drugs 851 - 875 of 13643 in total

Pimozide

A diphenylbutylpiperidine that is effective as an antipsychotic agent and as an alternative to haloperidol for the suppression of vocal and motor tics in patients with Tourette syndrome. Although the precise mechanism of action is unknown, blockade of postsynaptic dopamine receptors has been postulated. (From AMA Drug Evaluations Annual, 1994,...
Approved
Matched Description: … for the suppression of vocal and motor tics in patients with Tourette syndrome. ... A diphenylbutylpiperidine that is effective as an antipsychotic agent and as an alternative to haloperidol …
Matched Categories: … Cytochrome P-450 CYP1A2 Substrates with a Narrow Therapeutic Index ... Cytochrome P-450 CYP2D6 Substrates with a Narrow Therapeutic Index ... Cytochrome P-450 CYP3A4 Substrates with a Narrow Therapeutic Index ... Cytochrome P-450 CYP3A5 Substrates with a Narrow Therapeutic Index ... Cytochrome P-450 CYP3A7 Substrates with a Narrow Therapeutic Index …

Eletriptan

Eletriptan is a second generation triptan drug developed by Pfizer Inc for the treatment of migraine headaches.
Approved
Investigational
Matched Description: … Eletriptan is a second generation triptan drug developed by Pfizer Inc for the treatment of migraine …

Hydrocortamate

Hydrocortamate is a synthetic glucocorticoid used for its anti-inflammatory or immunosuppressive properties to treat inflammation due to corticosteroid-responsive dermatoses. Glucocorticoids are a class of steroid hormones characterised by an ability to bind with the cortisol receptor and trigger a variety of important cardiovascular, metabolic, immunologic and homeostatic effects.
Approved
Matched Iupac: … 1,10-dihydroxy-9a,11a-dimethyl-7-oxo-1H,2H,3H,3aH,3bH,4H,5H,7H,8H,9H,9aH,9bH,10H,11H,11aH-cyclopenta[a] …
Matched Description: … Hydrocortamate is a synthetic glucocorticoid used for its anti-inflammatory or immunosuppressive properties ... Glucocorticoids are a class of steroid hormones characterised by an ability to bind with the cortisol ... receptor and trigger a variety of important cardiovascular, metabolic, immunologic and homeostatic effects …

Vorinostat

Vorinostat (rINN) or suberoylanilide hydroxamic acid (SAHA), is a drug currently under investigation for the treatment of cutaneous T cell lymphoma (CTCL), a type of skin cancer, to be used when the disease persists, gets worse, or comes back during or after treatment with other medicines. It is the first...
Approved
Investigational
Matched Description: … for the treatment of cutaneous T cell lymphoma (CTCL), a type of skin cancer, to be used when the disease ... multiforme, resulting in a median overall survival of 5.7 months (compared to 4 - 4.4 months in earlier ... It is the first in a new class of agents known as histone deacetylase inhibitors. …

Piperazine

Piperazine is an organic compound that consists of a six-membered ring containing two opposing nitrogen atoms. First used as a solvent for uric acid, the use of piperazine as an anthelmintic agent was first introduced in 1953. Upon entry into the systemic circulation, the drug is partly oxidized and partly...
Approved
Vet approved
Matched Description: … First used as a solvent for uric acid, the use of piperazine as an anthelmintic agent was first introduced ... in 1953. ... Piperazine was first introduced as an anthelmintic in 1953. …

Copper oxodotreotide Cu-64

Copper Cu 64 dotatate is a newly approved Cu labeled somatostatin analog and has several advantages over 68Ga-labeled somatostatin analogs for positron emission tomography (PET). Copper Cu 64 dotatate has a longer half-life and can be produced once a day as opposed to several times a day, and lower positron...
Approved
Matched Description: … [A220348] In a head-to-head trial, the former tracer detected twice as many lesions as the latter. ... 68Ga-labeled somatostatin analogs for positron emission tomography (PET). ... [A220348] Copper Cu 64 dotatate has a longer half-life and can be produced once a day as opposed to several …

Hetacillin

Hetacillin is a penicillin beta-lactam antibiotic used in the treatment of bacterial infections caused by susceptible, usually gram-positive, organisms. The name "penicillin" can either refer to several variants of penicillin available, or to the group of antibiotics derived from the penicillins. Hetacillin has in vitro activity against gram-positive and gram-negative...
Approved
Vet approved
Withdrawn
Matched Description: … Hetacillin is a penicillin beta-lactam antibiotic used in the treatment of bacterial infections caused ... Hetacillin has in vitro activity against gram-positive and gram-negative aerobic and anaerobic bacteria …
Matched Categories: … Antibacterials for Systemic Use ... Antiinfectives for Systemic Use …

Promazine

A phenothiazine with actions similar to chlorpromazine but with less antipsychotic activity. It is primarily used in short-term treatment of disturbed behavior and as an antiemetic. It is currently not approved for use in the United States.
Approved
Vet approved
Matched Description: … It is currently not approved for use in the United States. ... A phenothiazine with actions similar to chlorpromazine but with less antipsychotic activity. ... It is primarily used in short-term treatment of disturbed behavior and as an antiemetic. …

Dexamethasone acetate

Commonly known as decadron, dexamethasone acetate is a glucocorticosteroid previously marketed in the USA for the treatment of inflammatory respiratory, allergic, autoimmune, and other conditions.[T797,L10695,L14348] Developed in 1957, dexamethasone is structurally similar to other corticosteroids such as hydrocortisone and prednisolone. Dexamethasone acetate has largely been replaced by dexamethasone phosphate and...
Approved
Investigational
Vet approved
Matched Iupac: … 9b-fluoro-1,10-dihydroxy-2,9a,11a-trimethyl-7-oxo-1H,2H,3H,3aH,3bH,4H,5H,7H,9aH,9bH,10H,11H,11aH-cyclopenta[a] …
Matched Description: … In a June 16 2020 press release highlighting early results of a clinical trial, Randomized Evaluation ... Dexamethasone was therefore recommended as a life-saving treatment for COVID-19 patients experiencing ... Commonly known as decadron, dexamethasone acetate is a glucocorticosteroid previously marketed in the …

Prasugrel

Prasugrel, a thienopyridine derivative, is a platelet activation and aggregation inhibitor structurally and pharmacologically related to clopidogrel and ticlopidine. Similar to clopidogrel, prasugrel is a prodrug that requires enzymatic transformation in the liver to its active metabolite, R-138727. R-138727 irreversibly binds to P2Y12 type ADP receptors on platelets thus preventing...
Approved
Matched Description: … in cooperation with Eli Lilly and Company for acute coronary syndromes planned for percutaneous coronary ... Similar to clopidogrel, prasugrel is a prodrug that requires enzymatic transformation in the liver to ... FDA approved in 2009. …

Digitoxin

A cardiac glycoside sometimes used in place of digoxin. It has a longer half-life than digoxin; toxic effects, which are similar to those of digoxin, are longer lasting. (From Martindale, The Extra Pharmacopoeia, 30th ed, p665)
Approved
Investigational
Matched Iupac: … methyloxan-2-yl]oxy}-4-hydroxy-6-methyloxan-2-yl]oxy}-3a-hydroxy-9a,11a-dimethyl-hexadecahydro-1H-cyclopenta[a] …
Matched Description: … A cardiac glycoside sometimes used in place of digoxin. ... It has a longer half-life than digoxin; toxic effects, which are similar to those of digoxin, are longer …
Matched Categories: … Compounds used in a research, industrial, or household setting ... P-glycoprotein substrates with a Narrow Therapeutic Index ... Cytochrome P-450 CYP3A4 Substrates with a Narrow Therapeutic Index …

Ixazomib

Ixazomib a second generation proteasome inhibitor (PI) and the first oral PI approved by the FDA in November 2015 for multiple myeloma treatment in combination with 2 other therapies (lenalidomide and dexamethasone) for patients who have received at least 1 prior therapy. It was found to have similar efficacy to...
Approved
Investigational
Matched Description: … Ixazomib a second generation proteasome inhibitor (PI) and the first oral PI approved by the FDA in November ... 2015 for multiple myeloma treatment in combination with 2 other therapies (lenalidomide and dexamethasone ... ) for patients who have received at least 1 prior therapy. …
Matched Categories: … Cytochrome P-450 CYP1A2 Substrates with a Narrow Therapeutic Index ... Cytochrome P-450 CYP2B6 Substrates with a Narrow Therapeutic Index ... Cytochrome P-450 CYP2C8 Substrates with a Narrow Therapeutic Index ... Cytochrome P-450 CYP2C19 Substrates with a Narrow Therapeutic Index ... Cytochrome P-450 CYP2C9 Substrates with a Narrow Therapeutic Index …

Ammonium chloride

Ammonium chloride is an inorganic compound with the formula NH4Cl. It is highly soluble in water producing mildly acidic solutions.
Approved
Investigational
Vet approved
Matched Description: … It is highly soluble in water producing mildly acidic solutions. …

Trimethaphan

A nicotinic antagonist that has been used as a ganglionic blocker in hypertension, as an adjunct to anesthesia, and to induce hypotension during surgery.
Approved
Investigational
Matched Description: … A nicotinic antagonist that has been used as a ganglionic blocker in hypertension, as an adjunct to anesthesia …

Norfloxacin

A synthetic fluoroquinolone (fluoroquinolones) with broad-spectrum antibacterial activity against most gram-negative and gram-positive bacteria. Norfloxacin inhibits bacterial DNA gyrase.
Approved
Matched Description: … A synthetic fluoroquinolone (fluoroquinolones) with broad-spectrum antibacterial activity against most …
Matched Categories: … Antibacterials for Systemic Use ... Antiinfectives for Systemic Use …

Donislecel

Donislecel is the first allogeneic pancreatic islet cellular from deceased donor pancreatic cells used for the treatment of adult type 1 diabetes with unsuccessful control of glycated hemoglobin, despite intensive diabetes management and treatments.[L47166,L47196] The primary mechanism of action of donislecel is attributed to the secretion of insulin and other...
Approved
Matched Description: … [L47196] Overall, 21 patients achieved insulin independence for a year or more, with 11 patients not ... [L47166,L47196] The approval of donislecel was based on the safety and effectiveness evaluated in 2 clinical ... needing insulin for 1 to 5 years and 10 patients for more than 5 years. …
Matched Categories: … Drugs Used in Diabetes …

4-(Isopropylamino)diphenylamine

4-(Isopropylamino)diphenylamine, also known as IPPD, is a chemical compound commonly used as an antiozonant in rubbers, particularly those used for tires. It is also a known allergen. Sensitivity to this compound may be identified with a clinical patch test.
Approved
Experimental
Matched Description: … in rubbers, particularly those used for tires. ... It is also a known allergen. ... Sensitivity to this compound may be identified with a clinical patch test. …
Matched Categories: … Compounds used in a research, industrial, or household setting …

Orciprenaline

A beta-adrenergic agonist used in the treatment of asthma and bronchospasms. [PubChem]
Approved
Matched Description: … A beta-adrenergic agonist used in the treatment of asthma and bronchospasms. [PubChem] …
Matched Categories: … Adrenergics for Systemic Use ... Drugs for Obstructive Airway Diseases …

Bromfenac

Bromfenac is a nonsteroidal anti-inflammatory drug (NSAID) for ophthalmic use. Ophthalmic NSAIDs are becoming a cornerstone for the management of ocular pain and inflammation. Their well-characterized anti-inflammatory activity, analgesic property, and established safety record have also made NSAIDs an important tool for optimizing surgical outcomes. Non-ophthalmic formulations of bromfenac were...
Approved
Withdrawn
Matched Description: … Bromfenac is a nonsteroidal anti-inflammatory drug (NSAID) for ophthalmic use. ... Ophthalmic NSAIDs are becoming a cornerstone for the management of ocular pain and inflammation. ... Non-ophthalmic formulations of bromfenac were withdrawn in the US in 1998 due to cases of severe liver …

Adiphenine

Approved
Withdrawn

Neurospora intermedia

Neurospora intermedia is a fungus which can provoke allergic reactions. Neurospora intermedia extract is used in allergenic testing.
Approved
Matched Description: … Neurospora intermedia extract is used in allergenic testing. ... Neurospora intermedia is a fungus which can provoke allergic reactions. …
Matched Mixtures name: … A Mold Mixture ... A Mold Mixture ... A Mold Mixture …

Somatrogon

Somatrogon is a long-acting recombinant human growth hormone. Growth hormone is a peptide hormone secreted by the pituitary gland that plays a crucial role in promoting longitudinal growth during childhood and adolescence and regulating metabolic function in adulthood. Recombinant growth hormone therapy for growth hormone deficiency and other conditions has...
Approved
Matched Description: … Growth hormone is a peptide hormone secreted by the pituitary gland that plays a crucial role in promoting ... [L39060] In June 2023, the FDA approved the use of somatrogon also for the treatment of pediatric growth ... available since 1985, with daily administration being the standard treatment for many years. …

Ublituximab

CD20, an antigen expressed by various B and T cells, is an attractive therapeutic target in various cancers and autoimmune conditions.[A244195, A244200, A244205] Monoclonal antibodies for B cell depletion rely on their binding affinity and ability to clear bound cells through mechanisms such as antibody-dependent cellular cytotoxicity (ADCC), mediated by...
Approved
Investigational
Matched Description: … allowing for administration in a one-hour infusion twice-a-year following the starting dose. ... [A244210] Ublituximab is a chimeric anti-CD20 IgG1κ antibody produced in the rat YB2/0 cell line to target ... It has been investigated for use in numerous B cell-dependent conditions, including chronic lymphocytic …

Pancuronium

A bis-quaternary steroid that is a competitive nicotinic antagonist. As a neuromuscular blocking agent it is more potent than curare but has less effect on the circulatory system and on histamine release.
Approved
Matched Iupac: … 11aS)-1,7-bis(acetyloxy)-9a,11a-dimethyl-8-(1-methylpiperidin-1-ium-1-yl)-hexadecahydro-1H-cyclopenta[a] …
Matched Description: … A bis-quaternary steroid that is a competitive nicotinic antagonist. ... As a neuromuscular blocking agent it is more potent than curare but has less effect on the circulatory …

Agomelatine

Agomelatine is structurally closely related to melatonin. Agomelatine is a potent agonist at melatonin receptors and an antagonist at serotonin-2C (5-HT2C) receptors, tested in an animal model of depression. Agomelatine was developed in Europe by Servier Laboratories Ltd. and submitted to the European Medicines Agency (EMA) in 2005. The Committee...
Approved
Investigational
Matched Description: … The development for the US market was discontinued in October 2011. ... Agomelatine is a potent agonist at melatonin receptors and an antagonist at serotonin-2C (5-HT2C) receptors ... The Committee for Medical Products for Human Use (CHMP) recommended refusal of marketing authorization …
Displaying drugs 851 - 875 of 13643 in total