| 2,5-Dimethoxy-4-ethylamphetamine | Promazine may decrease the stimulatory activities of 2,5-Dimethoxy-4-ethylamphetamine. | Experimental, Illicit |
| 3,4-Methylenedioxyamphetamine | Promazine may decrease the stimulatory activities of 3,4-Methylenedioxyamphetamine. | Experimental, Illicit |
| 3,4-Methylenedioxymethamphetamine | Promazine may decrease the stimulatory activities of 3,4-Methylenedioxymethamphetamine. | Experimental, Illicit |
| 4-Bromo-2,5-dimethoxyamphetamine | Promazine may decrease the stimulatory activities of 4-Bromo-2,5-dimethoxyamphetamine. | Experimental, Illicit |
| 4-Methoxyamphetamine | The metabolism of 4-Methoxyamphetamine can be decreased when combined with Promazine. | Experimental, Illicit |
| 5'-Deoxy-5'-Methylthioadenosine | The serum concentration of Promazine can be increased when it is combined with 5'-Deoxy-5'-Methylthioadenosine. | Experimental |
| 7-Nitroindazole | The risk or severity of adverse effects can be increased when Promazine is combined with 7-Nitroindazole. | Experimental |
| Abiraterone | The serum concentration of Promazine can be increased when it is combined with Abiraterone. | Approved |
| Acebutolol | Promazine may increase the hypotensive activities of Acebutolol. | Approved |
| Acepromazine | The risk or severity of adverse effects can be increased when Promazine is combined with Acepromazine. | Approved, Vet Approved |
| Aceprometazine | The risk or severity of adverse effects can be increased when Promazine is combined with Aceprometazine. | Approved |
| Acetaminophen | The metabolism of Acetaminophen can be decreased when combined with Promazine. | Approved |
| Acetylcholine | The metabolism of Acetylcholine can be decreased when combined with Promazine. | Approved |
| Adipiplon | The risk or severity of adverse effects can be increased when Promazine is combined with adipiplon. | Investigational |
| Agomelatine | The risk or severity of adverse effects can be increased when Promazine is combined with Agomelatine. | Approved, Investigational |
| Ajmaline | The metabolism of Ajmaline can be decreased when combined with Promazine. | Approved |
| Alfaxalone | The risk or severity of adverse effects can be increased when Promazine is combined with Alfaxalone. | Vet Approved |
| Alfentanil | The risk or severity of adverse effects can be increased when Promazine is combined with Alfentanil. | Approved, Illicit |
| Alfuzosin | Alfuzosin may increase the QTc-prolonging activities of Promazine. | Approved, Investigational |
| Allopregnanolone | The risk or severity of adverse effects can be increased when Promazine is combined with Sage 547. | Investigational |
| Almotriptan | The metabolism of Almotriptan can be decreased when combined with Promazine. | Approved, Investigational |
| Alogliptin | The metabolism of Alogliptin can be decreased when combined with Promazine. | Approved |
| Alphacetylmethadol | The risk or severity of adverse effects can be increased when Promazine is combined with Alphacetylmethadol. | Experimental, Illicit |
| Alprazolam | The risk or severity of adverse effects can be increased when Alprazolam is combined with Promazine. | Approved, Illicit, Investigational |
| Alprenolol | The metabolism of Alprenolol can be decreased when combined with Promazine. | Approved, Withdrawn |
| Aluminum hydroxide | Aluminum hydroxide can cause a decrease in the absorption of Promazine resulting in a reduced serum concentration and potentially a decrease in efficacy. | Approved |
| Amantadine | The therapeutic efficacy of Promazine can be decreased when used in combination with Amantadine. | Approved |
| Aminophenazone | The metabolism of Aminophenazone can be decreased when combined with Promazine. | Approved, Withdrawn |
| Amiodarone | Promazine may increase the QTc-prolonging activities of Amiodarone. | Approved, Investigational |
| Amisulpride | The risk or severity of adverse effects can be increased when Promazine is combined with Amisulpride. | Approved, Investigational |
| Amitriptyline | Amitriptyline may increase the QTc-prolonging activities of Promazine. | Approved |
| Amobarbital | The risk or severity of adverse effects can be increased when Promazine is combined with Amobarbital. | Approved, Illicit |
| Amodiaquine | The serum concentration of Promazine can be increased when it is combined with Amodiaquine. | Approved |
| Amoxapine | Amoxapine may increase the QTc-prolonging activities of Promazine. | Approved |
| Amperozide | The risk or severity of adverse effects can be increased when Promazine is combined with Amperozide. | Experimental |
| Amphetamine | The metabolism of Amphetamine can be decreased when combined with Promazine. | Approved, Illicit |
| Amprenavir | The metabolism of Amprenavir can be decreased when combined with Promazine. | Approved |
| Amsacrine | The metabolism of Amsacrine can be decreased when combined with Promazine. | Approved |
| Anagrelide | Promazine may increase the QTc-prolonging activities of Anagrelide. | Approved |
| Antipyrine | The metabolism of Antipyrine can be decreased when combined with Promazine. | Approved |
| Apomorphine | The therapeutic efficacy of Promazine can be decreased when used in combination with Apomorphine. | Approved, Investigational |
| Aprepitant | The serum concentration of Promazine can be increased when it is combined with Aprepitant. | Approved, Investigational |
| Aprindine | The metabolism of Aprindine can be decreased when combined with Promazine. | Approved |
| Arformoterol | Arformoterol may increase the QTc-prolonging activities of Promazine. | Approved, Investigational |
| Aripiprazole | The serum concentration of Aripiprazole can be increased when it is combined with Promazine. | Approved, Investigational |
| Armodafinil | The metabolism of Promazine can be decreased when combined with Armodafinil. | Approved, Investigational |
| Arotinolol | Promazine may increase the hypotensive activities of Arotinolol. | Approved |
| Arsenic trioxide | Promazine may increase the QTc-prolonging activities of Arsenic trioxide. | Approved, Investigational |
| Artemether | Promazine may increase the QTc-prolonging activities of Artemether. | Approved |
| Artemisinin | The serum concentration of Promazine can be increased when it is combined with Artemisinin. | Investigational |
| Artesunate | The serum concentration of Promazine can be increased when it is combined with Artesunate. | Approved |
| Articaine | The risk or severity of adverse effects can be increased when Promazine is combined with Articaine. | Approved |
| Asenapine | Promazine may increase the QTc-prolonging activities of Asenapine. | Approved |
| Astemizole | The metabolism of Astemizole can be decreased when combined with Promazine. | Approved, Withdrawn |
| Atazanavir | The metabolism of Promazine can be decreased when combined with Atazanavir. | Approved, Investigational |
| Atenolol | Promazine may increase the hypotensive activities of Atenolol. | Approved |
| Atomoxetine | Atomoxetine may increase the QTc-prolonging activities of Promazine. | Approved |
| Atovaquone | The serum concentration of Promazine can be increased when it is combined with Atovaquone. | Approved |
| Azelastine | Promazine may increase the central nervous system depressant (CNS depressant) activities of Azelastine. | Approved |
| Azelastine | The metabolism of Azelastine can be decreased when combined with Promazine. | Approved |
| Azithromycin | Azithromycin may increase the QTc-prolonging activities of Promazine. | Approved |
| Baclofen | The risk or severity of adverse effects can be increased when Promazine is combined with Baclofen. | Approved |
| Barbital | The risk or severity of adverse effects can be increased when Promazine is combined with Barbital. | Illicit |
| Bedaquiline | Promazine may increase the QTc-prolonging activities of Bedaquiline. | Approved |
| Befunolol | Promazine may increase the hypotensive activities of Befunolol. | Experimental |
| Benperidol | The risk or severity of adverse effects can be increased when Promazine is combined with Benperidol. | Investigational |
| Benzatropine | The metabolism of Benzatropine can be decreased when combined with Promazine. | Approved |
| Benzocaine | The risk or severity of adverse effects can be increased when Promazine is combined with Benzocaine. | Approved |
| Benzphetamine | Promazine may decrease the stimulatory activities of Benzphetamine. | Approved, Illicit |
| Benzyl alcohol | The metabolism of Benzyl alcohol can be decreased when combined with Promazine. | Approved |
| Bepridil | The metabolism of Bepridil can be decreased when combined with Promazine. | Approved, Withdrawn |
| Betaxolol | The metabolism of Betaxolol can be decreased when combined with Promazine. | Approved |
| Betulinic Acid | The serum concentration of Promazine can be increased when it is combined with Betulinic Acid. | Investigational |
| Bevantolol | Promazine may increase the hypotensive activities of Bevantolol. | Approved |
| Bexarotene | The serum concentration of Promazine can be decreased when it is combined with Bexarotene. | Approved, Investigational |
| Bezitramide | Promazine may increase the hypotensive activities of Bezitramide. | Experimental, Illicit, Withdrawn |
| Bismuth Subcitrate | Bismuth Subcitrate can cause a decrease in the absorption of Promazine resulting in a reduced serum concentration and potentially a decrease in efficacy. | Approved |
| Bisoprolol | The metabolism of Bisoprolol can be decreased when combined with Promazine. | Approved |
| Boceprevir | The metabolism of Promazine can be decreased when combined with Boceprevir. | Approved, Investigational |
| Bopindolol | Promazine may increase the hypotensive activities of Bopindolol. | Approved |
| Bortezomib | Bortezomib may increase the QTc-prolonging activities of Promazine. | Approved, Investigational |
| Bosentan | The serum concentration of Promazine can be decreased when it is combined with Bosentan. | Approved, Investigational |
| Brexpiprazole | The serum concentration of Brexpiprazole can be increased when it is combined with Promazine. | Approved |
| Brimonidine | The risk or severity of adverse effects can be increased when Promazine is combined with Brimonidine. | Approved |
| Brimonidine | Brimonidine may increase the central nervous system depressant (CNS depressant) activities of Promazine. | Approved |
| Bromazepam | The risk or severity of adverse effects can be increased when Promazine is combined with Bromazepam. | Approved, Illicit |
| Bromocriptine | The therapeutic efficacy of Promazine can be decreased when used in combination with Bromocriptine. | Approved, Investigational |
| Brompheniramine | The metabolism of Brompheniramine can be decreased when combined with Promazine. | Approved |
| Brotizolam | The risk or severity of adverse effects can be increased when Promazine is combined with Brotizolam. | Approved, Withdrawn |
| Bucindolol | Promazine may increase the hypotensive activities of Bucindolol. | Investigational |
| Bufuralol | The metabolism of Bufuralol can be decreased when combined with Promazine. | Experimental, Investigational |
| Bupivacaine | The metabolism of Bupivacaine can be decreased when combined with Promazine. | Approved, Investigational |
| Bupranolol | Promazine may increase the hypotensive activities of Bupranolol. | Approved |
| Buprenorphine | Promazine may increase the central nervous system depressant (CNS depressant) activities of Buprenorphine. | Approved, Illicit, Investigational, Vet Approved |
| Bupropion | The metabolism of Bupropion can be decreased when combined with Promazine. | Approved |
| Buserelin | Buserelin may increase the QTc-prolonging activities of Promazine. | Approved |
| Buspirone | The metabolism of Buspirone can be decreased when combined with Promazine. | Approved, Investigational |
| Butabarbital | The risk or severity of adverse effects can be increased when Butabarbital is combined with Promazine. | Approved, Illicit |
| Butalbital | The risk or severity of adverse effects can be increased when Promazine is combined with Butalbital. | Approved, Illicit |
| Butethal | The risk or severity of adverse effects can be increased when Promazine is combined with Butethal. | Approved, Illicit |
| Butorphanol | The risk or severity of adverse effects can be increased when Promazine is combined with Butorphanol. | Approved, Illicit, Vet Approved |
| Cabergoline | The risk or severity of adverse effects can be increased when Cabergoline is combined with Promazine. | Approved |
| Caffeine | The metabolism of Promazine can be decreased when combined with Caffeine. | Approved |
| Calcium Carbonate | Calcium carbonate can cause a decrease in the absorption of Promazine resulting in a reduced serum concentration and potentially a decrease in efficacy. | Approved |
| Capecitabine | The metabolism of Promazine can be decreased when combined with Capecitabine. | Approved, Investigational |
| Captopril | The metabolism of Captopril can be decreased when combined with Promazine. | Approved |
| Carbamazepine | The metabolism of Promazine can be increased when combined with Carbamazepine. | Approved, Investigational |
| Carbinoxamine | The risk or severity of adverse effects can be increased when Promazine is combined with Carbinoxamine. | Approved |
| Carfentanil | The risk or severity of adverse effects can be increased when Promazine is combined with Carfentanil. | Illicit, Vet Approved |
| Cariprazine | The metabolism of Cariprazine can be decreased when combined with Promazine. | Approved |
| Carisoprodol | The risk or severity of adverse effects can be increased when Promazine is combined with Carisoprodol. | Approved |
| Carteolol | The metabolism of Carteolol can be decreased when combined with Promazine. | Approved |
| Carvedilol | The metabolism of Carvedilol can be decreased when combined with Promazine. | Approved, Investigational |
| Celiprolol | Promazine may increase the hypotensive activities of Celiprolol. | Approved, Investigational |
| Cephalexin | The metabolism of Cephalexin can be decreased when combined with Promazine. | Approved, Vet Approved |
| Ceritinib | The serum concentration of Promazine can be increased when it is combined with Ceritinib. | Approved |
| Cetirizine | The risk or severity of adverse effects can be increased when Promazine is combined with Cetirizine. | Approved |
| Cevimeline | The metabolism of Cevimeline can be decreased when combined with Promazine. | Approved |
| Chloral hydrate | The risk or severity of adverse effects can be increased when Promazine is combined with Chloral hydrate. | Approved, Illicit, Vet Approved |
| Chloramphenicol | The metabolism of Promazine can be decreased when combined with Chloramphenicol. | Approved, Vet Approved |
| Chlordiazepoxide | The metabolism of Chlordiazepoxide can be decreased when combined with Promazine. | Approved, Illicit |
| Chlormezanone | The risk or severity of adverse effects can be increased when Promazine is combined with Chlormezanone. | Approved, Withdrawn |
| Chloroprocaine | The risk or severity of adverse effects can be increased when Promazine is combined with Chloroprocaine. | Approved |
| Chloroquine | Promazine may increase the QTc-prolonging activities of Chloroquine. | Approved, Vet Approved |
| Chlorphenamine | The metabolism of Chlorphenamine can be decreased when combined with Promazine. | Approved |
| Chlorphentermine | Promazine may decrease the stimulatory activities of Chlorphentermine. | Illicit, Withdrawn |
| Chlorpromazine | Promazine may increase the QTc-prolonging activities of Chlorpromazine. | Approved, Vet Approved |
| Chlorprothixene | The risk or severity of adverse effects can be increased when Promazine is combined with Chlorprothixene. | Approved, Withdrawn |
| Chlorzoxazone | The metabolism of Chlorzoxazone can be decreased when combined with Promazine. | Approved |
| Cholecalciferol | The metabolism of Promazine can be decreased when combined with Cholecalciferol. | Approved, Nutraceutical |
| Cilostazol | The metabolism of Cilostazol can be decreased when combined with Promazine. | Approved |
| Cimetidine | The metabolism of Promazine can be decreased when combined with Cimetidine. | Approved |
| Cinchocaine | The risk or severity of adverse effects can be increased when Promazine is combined with Cinchocaine. | Approved, Vet Approved |
| Cinnarizine | The metabolism of Cinnarizine can be decreased when combined with Promazine. | Approved |
| Ciprofloxacin | Promazine may increase the QTc-prolonging activities of Ciprofloxacin. | Approved, Investigational |
| Cisapride | Promazine may increase the QTc-prolonging activities of Cisapride. | Approved, Investigational, Withdrawn |
| Citalopram | Promazine may increase the QTc-prolonging activities of Citalopram. | Approved |
| Clarithromycin | Promazine may increase the QTc-prolonging activities of Clarithromycin. | Approved |
| Clemastine | The metabolism of Promazine can be decreased when combined with Clemastine. | Approved |
| Clevidipine | The metabolism of Clevidipine can be decreased when combined with Promazine. | Approved |
| Clidinium | The risk or severity of adverse effects can be increased when Promazine is combined with Clidinium. | Approved |
| Clobazam | The risk or severity of adverse effects can be increased when Promazine is combined with Clobazam. | Approved, Illicit |
| Clomipramine | Clomipramine may increase the QTc-prolonging activities of Promazine. | Approved, Vet Approved |
| Clonazepam | The risk or severity of adverse effects can be increased when Promazine is combined with Clonazepam. | Approved, Illicit |
| Clonidine | The metabolism of Clonidine can be decreased when combined with Promazine. | Approved |
| Clorazepate | The risk or severity of adverse effects can be increased when Promazine is combined with Clorazepate. | Approved, Illicit |
| Clotrimazole | The metabolism of Promazine can be decreased when combined with Clotrimazole. | Approved, Vet Approved |
| Clozapine | Clozapine may increase the QTc-prolonging activities of Promazine. | Approved |
| Cobicistat | The metabolism of Promazine can be decreased when combined with Cobicistat. | Approved |
| Cocaine | The risk or severity of adverse effects can be increased when Promazine is combined with Cocaine. | Approved, Illicit |
| Codeine | The therapeutic efficacy of Codeine can be decreased when used in combination with Promazine. | Approved, Illicit |
| Conivaptan | The serum concentration of Promazine can be increased when it is combined with Conivaptan. | Approved, Investigational |
| Crizotinib | Promazine may increase the QTc-prolonging activities of Crizotinib. | Approved |
| Cyclizine | The risk or severity of adverse effects can be increased when Promazine is combined with Cyclizine. | Approved |
| Cyclobenzaprine | The metabolism of Cyclobenzaprine can be decreased when combined with Promazine. | Approved |
| Cyclophosphamide | The metabolism of Cyclophosphamide can be decreased when combined with Promazine. | Approved, Investigational |
| Cyclosporine | The metabolism of Promazine can be decreased when combined with Cyclosporine. | Approved, Investigational, Vet Approved |
| Cyproheptadine | The risk or severity of adverse effects can be increased when Promazine is combined with Cyproheptadine. | Approved |
| Cyproterone acetate | The serum concentration of Promazine can be decreased when it is combined with Cyproterone acetate. | Approved, Investigational |
| Dabrafenib | The serum concentration of Promazine can be decreased when it is combined with Dabrafenib. | Approved |
| Dantrolene | The risk or severity of adverse effects can be increased when Promazine is combined with Dantrolene. | Approved |
| Dapagliflozin | The metabolism of Dapagliflozin can be decreased when combined with Promazine. | Approved |
| Dapiprazole | The risk or severity of adverse effects can be increased when Dapiprazole is combined with Promazine. | Approved |
| Dapoxetine | The risk or severity of adverse effects can be increased when Promazine is combined with Dapoxetine. | Investigational |
| Dapsone | The serum concentration of Promazine can be increased when it is combined with Dapsone. | Approved, Investigational |
| Darifenacin | The metabolism of Darifenacin can be decreased when combined with Promazine. | Approved, Investigational |
| Darunavir | The metabolism of Promazine can be decreased when combined with Darunavir. | Approved |
| Dasabuvir | The metabolism of Dasabuvir can be decreased when combined with Promazine. | Approved |
| Dasatinib | The serum concentration of Promazine can be increased when it is combined with Dasatinib. | Approved, Investigational |
| Debrisoquin | The metabolism of Debrisoquin can be decreased when combined with Promazine. | Approved |
| Deferasirox | The serum concentration of Promazine can be decreased when it is combined with Deferasirox. | Approved, Investigational |
| Degarelix | Degarelix may increase the QTc-prolonging activities of Promazine. | Approved |
| Delavirdine | The metabolism of Promazine can be decreased when combined with Delavirdine. | Approved |
| Deramciclane | The risk or severity of adverse effects can be increased when Promazine is combined with deramciclane. | Investigational |
| Desflurane | Desflurane may increase the QTc-prolonging activities of Promazine. | Approved |
| Desipramine | Desipramine may increase the QTc-prolonging activities of Promazine. | Approved |
| Desloratadine | The risk or severity of adverse effects can be increased when Promazine is combined with Desloratadine. | Approved, Investigational |
| Desvenlafaxine | The risk or severity of adverse effects can be increased when Desvenlafaxine is combined with Promazine. | Approved |
| Dexamethasone | The serum concentration of Promazine can be decreased when it is combined with Dexamethasone. | Approved, Investigational, Vet Approved |
| Dexbrompheniramine | The risk or severity of adverse effects can be increased when Promazine is combined with Dexbrompheniramine. | Approved |
| Dexfenfluramine | The metabolism of Dexfenfluramine can be decreased when combined with Promazine. | Approved, Illicit, Withdrawn |
| Dexmedetomidine | The risk or severity of adverse effects can be increased when Promazine is combined with Dexmedetomidine. | Approved, Vet Approved |
| Dexmethylphenidate | The metabolism of Dexmethylphenidate can be decreased when combined with Promazine. | Approved |
| Dextroamphetamine | The metabolism of Dextroamphetamine can be decreased when combined with Promazine. | Approved, Illicit |
| Dextromethorphan | The metabolism of Dextromethorphan can be decreased when combined with Promazine. | Approved |
| Dextromoramide | The risk or severity of adverse effects can be increased when Promazine is combined with Dextromoramide. | Experimental, Illicit |
| Dextropropoxyphene | The risk or severity of adverse effects can be increased when Promazine is combined with Dextropropoxyphene. | Approved, Illicit, Withdrawn |
| Dezocine | The risk or severity of adverse effects can be increased when Promazine is combined with Dezocine. | Approved |
| Diazepam | The risk or severity of adverse effects can be increased when Promazine is combined with Diazepam. | Approved, Illicit, Vet Approved |
| Diethylpropion | Promazine may decrease the stimulatory activities of Diethylpropion. | Approved, Illicit |
| Difenoxin | The risk or severity of adverse effects can be increased when Promazine is combined with Difenoxin. | Approved, Illicit |
| Dihydrocodeine | The metabolism of Dihydrocodeine can be decreased when combined with Promazine. | Approved, Illicit |
| Dihydroergotamine | The metabolism of Promazine can be decreased when combined with Dihydroergotamine. | Approved |
| Dihydroetorphine | The risk or severity of adverse effects can be increased when Promazine is combined with Dihydroetorphine. | Experimental, Illicit |
| Dihydromorphine | The risk or severity of adverse effects can be increased when Promazine is combined with Dihydromorphine. | Experimental, Illicit |
| Diltiazem | The metabolism of Promazine can be decreased when combined with Diltiazem. | Approved |
| Dimenhydrinate | The risk or severity of adverse effects can be increased when Promazine is combined with Dimenhydrinate. | Approved |
| Diphenhydramine | Diphenhydramine may increase the QTc-prolonging activities of Promazine. | Approved |
| Diphenoxylate | The risk or severity of adverse effects can be increased when Promazine is combined with Diphenoxylate. | Approved, Illicit |
| Disopyramide | Promazine may increase the QTc-prolonging activities of Disopyramide. | Approved |
| Dofetilide | Promazine may increase the QTc-prolonging activities of Dofetilide. | Approved |
| Dolasetron | Promazine may increase the QTc-prolonging activities of Dolasetron. | Approved |
| Domperidone | Promazine may increase the QTc-prolonging activities of Domperidone. | Approved, Investigational, Vet Approved |
| Donepezil | The metabolism of Donepezil can be decreased when combined with Promazine. | Approved |
| Dopamine | The metabolism of Dopamine can be decreased when combined with Promazine. | Approved |
| Doxazosin | The metabolism of Doxazosin can be decreased when combined with Promazine. | Approved |
| Doxepin | Doxepin may increase the QTc-prolonging activities of Promazine. | Approved |
| Doxorubicin | The serum concentration of Doxorubicin can be increased when it is combined with Promazine. | Approved, Investigational |
| Doxorubicin | The metabolism of Doxorubicin can be decreased when combined with Promazine. | Approved, Investigational |
| Doxycycline | The serum concentration of Promazine can be increased when it is combined with Doxycycline. | Approved, Investigational, Vet Approved |
| Doxylamine | Doxylamine may increase the central nervous system depressant (CNS depressant) activities of Promazine. | Approved, Vet Approved |
| Dronabinol | Dronabinol may increase the central nervous system depressant (CNS depressant) activities of Promazine. | Approved, Illicit |
| Dronedarone | Promazine may increase the QTc-prolonging activities of Dronedarone. | Approved |
| Droperidol | Droperidol may increase the central nervous system depressant (CNS depressant) activities of Promazine. | Approved, Vet Approved |
| Drotebanol | The risk or severity of adverse effects can be increased when Promazine is combined with Drotebanol. | Experimental, Illicit |
| Duloxetine | The metabolism of Duloxetine can be decreased when combined with Promazine. | Approved |
| Dyclonine | The risk or severity of adverse effects can be increased when Promazine is combined with Dyclonine. | Approved |
| Ecgonine | The risk or severity of adverse effects can be increased when Promazine is combined with Ecgonine. | Experimental, Illicit |
| Ecopipam | The risk or severity of adverse effects can be increased when Promazine is combined with Ecopipam. | Investigational |
| Efavirenz | The serum concentration of Promazine can be decreased when it is combined with Efavirenz. | Approved, Investigational |
| Eletriptan | The metabolism of Eletriptan can be decreased when combined with Promazine. | Approved, Investigational |
| Eliglustat | The serum concentration of Eliglustat can be increased when it is combined with Promazine. | Approved |
| Eltanolone | The risk or severity of adverse effects can be increased when Promazine is combined with Pregnanolone. | Investigational |
| Encainide | The metabolism of Encainide can be decreased when combined with Promazine. | Approved, Withdrawn |
| Enclomiphene | The metabolism of Enclomiphene can be decreased when combined with Promazine. | Investigational |
| Enflurane | The risk or severity of adverse effects can be increased when Enflurane is combined with Promazine. | Approved, Vet Approved |
| Entacapone | The risk or severity of adverse effects can be increased when Promazine is combined with Entacapone. | Approved, Investigational |
| Enzalutamide | The serum concentration of Promazine can be decreased when it is combined with Enzalutamide. | Approved |
| Epinastine | The metabolism of Epinastine can be decreased when combined with Promazine. | Approved, Investigational |
| Ergoloid mesylate | The risk or severity of adverse effects can be increased when Ergoloid mesylate is combined with Promazine. | Approved |
| Ergonovine | The risk or severity of adverse effects can be increased when Ergonovine is combined with Promazine. | Approved |
| Ergotamine | The risk or severity of adverse effects can be increased when Ergotamine is combined with Promazine. | Approved |
| Eribulin | Eribulin may increase the QTc-prolonging activities of Promazine. | Approved, Investigational |
| Erlotinib | The metabolism of Erlotinib can be decreased when combined with Promazine. | Approved, Investigational |
| Erythromycin | Erythromycin may increase the QTc-prolonging activities of Promazine. | Approved, Vet Approved |
| Escitalopram | Promazine may increase the QTc-prolonging activities of Escitalopram. | Approved, Investigational |
| Eslicarbazepine acetate | The serum concentration of Promazine can be decreased when it is combined with Eslicarbazepine acetate. | Approved |
| Esmirtazapine | The metabolism of Esmirtazapine can be decreased when combined with Promazine. | Investigational |
| Esmolol | Promazine may increase the hypotensive activities of Esmolol. | Approved |
| Esomeprazole | The metabolism of Promazine can be decreased when combined with Esomeprazole. | Approved, Investigational |
| Estazolam | The risk or severity of adverse effects can be increased when Promazine is combined with Estazolam. | Approved, Illicit |
| Eszopiclone | The risk or severity of adverse effects can be increased when Eszopiclone is combined with Promazine. | Approved |
| Ethanol | Promazine may increase the central nervous system depressant (CNS depressant) activities of Ethanol. | Approved |
| Ethchlorvynol | The risk or severity of adverse effects can be increased when Ethchlorvynol is combined with Promazine. | Approved, Illicit, Withdrawn |
| Ethosuximide | The risk or severity of adverse effects can be increased when Promazine is combined with Ethosuximide. | Approved |
| Ethotoin | The risk or severity of adverse effects can be increased when Promazine is combined with Ethotoin. | Approved |
| Ethyl carbamate | The risk or severity of adverse effects can be increased when Promazine is combined with Ethyl carbamate. | Withdrawn |
| Ethyl loflazepate | The risk or severity of adverse effects can be increased when Promazine is combined with Ethyl loflazepate. | Approved, Illicit |
| Ethylmorphine | The metabolism of Ethylmorphine can be decreased when combined with Promazine. | Approved, Illicit |
| Etidocaine | The risk or severity of adverse effects can be increased when Promazine is combined with Etidocaine. | Approved |
| Etifoxine | The risk or severity of adverse effects can be increased when Promazine is combined with Etifoxine. | Withdrawn |
| Etizolam | The risk or severity of adverse effects can be increased when Promazine is combined with Etizolam. | Approved |
| Etomidate | The risk or severity of adverse effects can be increased when Etomidate is combined with Promazine. | Approved |
| Etoperidone | The risk or severity of adverse effects can be increased when Promazine is combined with Etoperidone. | Approved |
| Etoricoxib | The metabolism of Etoricoxib can be decreased when combined with Promazine. | Approved, Investigational |
| Etorphine | The risk or severity of adverse effects can be increased when Promazine is combined with Etorphine. | Illicit, Vet Approved |
| Etravirine | The serum concentration of Promazine can be decreased when it is combined with Etravirine. | Approved |
| Ezogabine | Ezogabine may increase the QTc-prolonging activities of Promazine. | Approved |
| Famotidine | Famotidine may increase the QTc-prolonging activities of Promazine. | Approved |
| Felbamate | Felbamate may increase the QTc-prolonging activities of Promazine. | Approved |
| Fencamfamine | The risk or severity of adverse effects can be increased when Promazine is combined with Fencamfamine. | Approved, Illicit, Withdrawn |
| Fenfluramine | The risk or severity of adverse effects can be increased when Promazine is combined with Fenfluramine. | Illicit, Withdrawn |
| Fentanyl | The risk or severity of adverse effects can be increased when Promazine is combined with Fentanyl. | Approved, Illicit, Investigational, Vet Approved |
| Fesoterodine | The metabolism of Fesoterodine can be decreased when combined with Promazine. | Approved |
| Fexofenadine | The risk or severity of adverse effects can be increased when Promazine is combined with Fexofenadine. | Approved |
| Fingolimod | Fingolimod may increase the QTc-prolonging activities of Promazine. | Approved, Investigational |
| Flecainide | Promazine may increase the QTc-prolonging activities of Flecainide. | Approved, Withdrawn |
| Flibanserin | The risk or severity of adverse effects can be increased when Promazine is combined with Flibanserin. | Approved |
| Floxuridine | The metabolism of Promazine can be decreased when combined with Floxuridine. | Approved |
| Fluconazole | The metabolism of Promazine can be decreased when combined with Fluconazole. | Approved |
| Fludiazepam | The risk or severity of adverse effects can be increased when Promazine is combined with Fludiazepam. | Approved, Illicit |
| Flunarizine | The metabolism of Flunarizine can be decreased when combined with Promazine. | Approved |
| Flunitrazepam | The risk or severity of adverse effects can be increased when Promazine is combined with Flunitrazepam. | Approved, Illicit |
| Fluorouracil | The metabolism of Promazine can be decreased when combined with Fluorouracil. | Approved |
| Fluoxetine | Promazine may increase the QTc-prolonging activities of Fluoxetine. | Approved, Vet Approved |
| Flupentixol | Promazine may increase the QTc-prolonging activities of Flupentixol. | Approved, Withdrawn |
| Fluphenazine | The metabolism of Fluphenazine can be decreased when combined with Promazine. | Approved |
| Flurazepam | The risk or severity of adverse effects can be increased when Promazine is combined with Flurazepam. | Approved, Illicit |
| Fluspirilene | The risk or severity of adverse effects can be increased when Promazine is combined with Fluspirilene. | Approved |
| Fluticasone propionate | The risk or severity of adverse effects can be increased when Promazine is combined with Fluticasone Propionate. | Approved |
| Fluvastatin | The metabolism of Fluvastatin can be decreased when combined with Promazine. | Approved |
| Fluvoxamine | The metabolism of Promazine can be decreased when combined with Fluvoxamine. | Approved, Investigational |
| Formoterol | Formoterol may increase the QTc-prolonging activities of Promazine. | Approved, Investigational |
| Fosamprenavir | The metabolism of Promazine can be decreased when combined with Fosamprenavir. | Approved |
| Fosaprepitant | The serum concentration of Promazine can be increased when it is combined with Fosaprepitant. | Approved |
| Foscarnet | Foscarnet may increase the QTc-prolonging activities of Promazine. | Approved |
| Fosphenytoin | The metabolism of Promazine can be increased when combined with Fosphenytoin. | Approved |
| Fospropofol | The risk or severity of adverse effects can be increased when Promazine is combined with Fospropofol. | Approved, Illicit |
| Frovatriptan | The risk or severity of adverse effects can be increased when Frovatriptan is combined with Promazine. | Approved, Investigational |
| Fusidic Acid | The serum concentration of Promazine can be increased when it is combined with Fusidic Acid. | Approved |
| Gabapentin | The risk or severity of adverse effects can be increased when Promazine is combined with Gabapentin. | Approved, Investigational |
| Gabapentin Enacarbil | The risk or severity of adverse effects can be increased when Promazine is combined with gabapentin enacarbil. | Approved |
| Gadobenic acid | Promazine may increase the QTc-prolonging activities of Gadobenic acid. | Approved |
| Galantamine | Galantamine may increase the QTc-prolonging activities of Promazine. | Approved |
| Gamma Hydroxybutyric Acid | The risk or severity of adverse effects can be increased when Promazine is combined with Gamma Hydroxybutyric Acid. | Approved, Illicit |
| Gefitinib | The metabolism of Gefitinib can be decreased when combined with Promazine. | Approved, Investigational |
| Gemfibrozil | The metabolism of Promazine can be decreased when combined with Gemfibrozil. | Approved |
| Gemifloxacin | Promazine may increase the QTc-prolonging activities of Gemifloxacin. | Approved, Investigational |
| Gepirone | The risk or severity of adverse effects can be increased when Promazine is combined with Gepirone. | Investigational |
| Glutethimide | The risk or severity of adverse effects can be increased when Promazine is combined with Glutethimide. | Approved, Illicit |
| Goserelin | Goserelin may increase the QTc-prolonging activities of Promazine. | Approved |
| Granisetron | Promazine may increase the QTc-prolonging activities of Granisetron. | Approved, Investigational |
| Guanfacine | The risk or severity of adverse effects can be increased when Promazine is combined with Guanfacine. | Approved, Investigational |
| Halazepam | The risk or severity of adverse effects can be increased when Promazine is combined with Halazepam. | Approved, Illicit, Withdrawn |
| Halofantrine | The serum concentration of Promazine can be increased when it is combined with Halofantrine. | Approved |
| Haloperidol | Promazine may increase the QTc-prolonging activities of Haloperidol. | Approved |
| Halothane | The metabolism of Halothane can be decreased when combined with Promazine. | Approved, Vet Approved |
| Heroin | The risk or severity of adverse effects can be increased when Promazine is combined with Heroin. | Approved, Illicit |
| Hexobarbital | The risk or severity of adverse effects can be increased when Promazine is combined with Hexobarbital. | Approved |
| Histrelin | Histrelin may increase the QTc-prolonging activities of Promazine. | Approved |
| Hydrocodone | Promazine may increase the central nervous system depressant (CNS depressant) activities of Hydrocodone. | Approved, Illicit |
| Hydromorphone | The metabolism of Hydromorphone can be decreased when combined with Promazine. | Approved, Illicit |
| Hydroxyamphetamine | Promazine may decrease the stimulatory activities of Hydroxyamphetamine hydrobromide. | Approved |
| Hydroxychloroquine | The serum concentration of Promazine can be increased when it is combined with Hydroxychloroquine. | Approved |
| Hydroxyzine | Hydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Promazine. | Approved |
| Ibandronate | Ibandronate may increase the QTc-prolonging activities of Promazine. | Approved, Investigational |
| Ibrutinib | The metabolism of Ibrutinib can be decreased when combined with Promazine. | Approved |
| Ibutilide | Promazine may increase the QTc-prolonging activities of Ibutilide. | Approved |
| Idarubicin | The metabolism of Idarubicin can be decreased when combined with Promazine. | Approved |
| Idelalisib | The serum concentration of Promazine can be increased when it is combined with Idelalisib. | Approved |
| Iloperidone | Promazine may increase the QTc-prolonging activities of Iloperidone. | Approved |
| Imatinib | The metabolism of Promazine can be decreased when combined with Imatinib. | Approved |
| Imipramine | Imipramine may increase the QTc-prolonging activities of Promazine. | Approved |
| Indacaterol | Indacaterol may increase the QTc-prolonging activities of Promazine. | Approved |
| Indalpine | The risk or severity of adverse effects can be increased when Promazine is combined with Indalpine. | Investigational, Withdrawn |
| Indapamide | Indapamide may increase the QTc-prolonging activities of Promazine. | Approved |
| Indenolol | Promazine may increase the hypotensive activities of Indenolol. | Withdrawn |
| Indinavir | The metabolism of Promazine can be decreased when combined with Indinavir. | Approved |
| Ipratropium bromide | The metabolism of Ipratropium bromide can be decreased when combined with Promazine. | Approved |
| Irbesartan | The metabolism of Promazine can be decreased when combined with Irbesartan. | Approved, Investigational |
| Isavuconazonium | The metabolism of Promazine can be decreased when combined with Isavuconazonium. | Approved, Investigational |
| Isocarboxazid | The risk or severity of adverse effects can be increased when Isocarboxazid is combined with Promazine. | Approved |
| Isoflurane | Isoflurane may increase the QTc-prolonging activities of Promazine. | Approved, Vet Approved |
| Isoniazid | The metabolism of Promazine can be decreased when combined with Isoniazid. | Approved |
| Isradipine | Isradipine may increase the QTc-prolonging activities of Promazine. | Approved |
| Itraconazole | The metabolism of Promazine can be decreased when combined with Itraconazole. | Approved, Investigational |
| Ivabradine | Ivabradine may increase the QTc-prolonging activities of Promazine. | Approved |
| Ivacaftor | The serum concentration of Promazine can be increased when it is combined with Ivacaftor. | Approved |
| Ixazomib | The metabolism of Ixazomib can be decreased when combined with Promazine. | Approved |
| Ketamine | The risk or severity of adverse effects can be increased when Promazine is combined with Ketamine. | Approved, Vet Approved |
| Ketazolam | The risk or severity of adverse effects can be increased when Promazine is combined with Ketazolam. | Approved |
| Ketobemidone | The risk or severity of adverse effects can be increased when Promazine is combined with Ketobemidone. | Approved |
| Ketoconazole | The metabolism of Promazine can be decreased when combined with Ketoconazole. | Approved, Investigational |
| Labetalol | The metabolism of Labetalol can be decreased when combined with Promazine. | Approved |
| Lamotrigine | The risk or severity of adverse effects can be increased when Promazine is combined with Lamotrigine. | Approved, Investigational |
| Landiolol | Promazine may increase the hypotensive activities of Aop200704. | Investigational |
| Lapatinib | Lapatinib may increase the QTc-prolonging activities of Promazine. | Approved, Investigational |
| Leflunomide | The metabolism of Promazine can be decreased when combined with Leflunomide. | Approved, Investigational |
| Lenvatinib | Promazine may increase the QTc-prolonging activities of Lenvatinib. | Approved |
| Leuprolide | Leuprolide may increase the QTc-prolonging activities of Promazine. | Approved, Investigational |
| Levetiracetam | The risk or severity of adverse effects can be increased when Promazine is combined with Levetiracetam. | Approved, Investigational |
| Levobunolol | Promazine may increase the hypotensive activities of Levobunolol. | Approved |
| Levobupivacaine | The risk or severity of adverse effects can be increased when Promazine is combined with Levobupivacaine. | Approved |
| Levocabastine | The risk or severity of adverse effects can be increased when Promazine is combined with Levocabastine. | Approved |
| Levocetirizine | The risk or severity of adverse effects can be increased when Promazine is combined with Levocetirizine. | Approved |
| Levodopa | The therapeutic efficacy of Promazine can be decreased when used in combination with Levodopa. | Approved |
| Levofloxacin | Promazine may increase the QTc-prolonging activities of Levofloxacin. | Approved, Investigational |
| Levomethadyl Acetate | The risk or severity of adverse effects can be increased when Promazine is combined with Levomethadyl Acetate. | Approved |
| Levomilnacipran | The metabolism of Levomilnacipran can be decreased when combined with Promazine. | Approved |
| Levorphanol | The risk or severity of adverse effects can be increased when Promazine is combined with Levorphanol. | Approved |
| Lidocaine | The metabolism of Promazine can be decreased when combined with Lidocaine. | Approved, Vet Approved |
| Linezolid | The risk or severity of adverse effects can be increased when Linezolid is combined with Promazine. | Approved, Investigational |
| Lisdexamfetamine | Promazine may decrease the stimulatory activities of Lisdexamfetamine. | Approved, Investigational |
| Lisuride | The metabolism of Lisuride can be decreased when combined with Promazine. | Approved |
| Lithium | Lithium may increase the neurotoxic activities of Promazine. | Approved |
| Lofentanil | The risk or severity of adverse effects can be increased when Promazine is combined with Lofentanil. | Illicit |
| Lomustine | The metabolism of Lomustine can be decreased when combined with Promazine. | Approved |
| Loperamide | The metabolism of Loperamide can be decreased when combined with Promazine. | Approved |
| Lopinavir | Promazine may increase the QTc-prolonging activities of Lopinavir. | Approved |
| Loratadine | The metabolism of Loratadine can be decreased when combined with Promazine. | Approved |
| Lorazepam | The risk or severity of adverse effects can be increased when Lorazepam is combined with Promazine. | Approved |
| Lorcaserin | The metabolism of Lorcaserin can be decreased when combined with Promazine. | Approved |
| Losartan | The metabolism of Promazine can be decreased when combined with Losartan. | Approved |
| Lovastatin | The metabolism of Promazine can be decreased when combined with Lovastatin. | Approved, Investigational |
| Loxapine | The risk or severity of adverse effects can be increased when Loxapine is combined with Promazine. | Approved |
| Luliconazole | The serum concentration of Promazine can be increased when it is combined with Luliconazole. | Approved |
| Lumacaftor | The serum concentration of Promazine can be decreased when it is combined with Lumacaftor. | Approved |
| Lumefantrine | Promazine may increase the QTc-prolonging activities of Lumefantrine. | Approved |
| Lurasidone | The risk or severity of adverse effects can be increased when Promazine is combined with Lurasidone. | Approved |
| Magaldrate | Magaldrate can cause a decrease in the absorption of Promazine resulting in a reduced serum concentration and potentially a decrease in efficacy. | Withdrawn |
| Magnesium carbonate | Magnesium carbonate can cause a decrease in the absorption of Promazine resulting in a reduced serum concentration and potentially a decrease in efficacy. | Approved |
| Magnesium Hydroxide | Magnesium hydroxide can cause a decrease in the absorption of Promazine resulting in a reduced serum concentration and potentially a decrease in efficacy. | Approved |
| Magnesium oxide | Magnesium oxide can cause a decrease in the absorption of Promazine resulting in a reduced serum concentration and potentially a decrease in efficacy. | Approved |
| Magnesium Sulfate | Magnesium Sulfate may increase the central nervous system depressant (CNS depressant) activities of Promazine. | Approved, Vet Approved |
| Magnesium Trisilicate | Magnesium Trisilicate can cause a decrease in the absorption of Promazine resulting in a reduced serum concentration and potentially a decrease in efficacy. | Approved |
| Maprotiline | Maprotiline may increase the QTc-prolonging activities of Promazine. | Approved |
| Meclizine | The risk or severity of adverse effects can be increased when Promazine is combined with Meclizine. | Approved |
| Mefloquine | The serum concentration of Promazine can be increased when it is combined with Mefloquine. | Approved |
| Melatonin | The risk or severity of adverse effects can be increased when Promazine is combined with Melatonin. | Approved, Nutraceutical, Vet Approved |
| Melperone | The risk or severity of adverse effects can be increased when Promazine is combined with Melperone. | Approved |
| Mephedrone | Promazine may decrease the stimulatory activities of Mephedrone. | Investigational |
| Mephentermine | Promazine may decrease the stimulatory activities of Mephentermine. | Approved |
| Mephenytoin | The metabolism of Mephenytoin can be decreased when combined with Promazine. | Investigational, Withdrawn |
| Mepivacaine | The risk or severity of adverse effects can be increased when Promazine is combined with Mepivacaine. | Approved, Vet Approved |
| Meprobamate | The risk or severity of adverse effects can be increased when Meprobamate is combined with Promazine. | Approved, Illicit |
| Mequitazine | Promazine may increase the arrhythmogenic activities of Mequitazine. | Approved |
| Mesoridazine | The metabolism of Mesoridazine can be decreased when combined with Promazine. | Approved |
| Metaxalone | The risk or severity of adverse effects can be increased when Promazine is combined with Metaxalone. | Approved |
| Methadone | Methadone may increase the QTc-prolonging activities of Promazine. | Approved |
| Methadyl Acetate | The risk or severity of adverse effects can be increased when Promazine is combined with Methadyl Acetate. | Approved, Illicit |
| Methamphetamine | The metabolism of Methamphetamine can be decreased when combined with Promazine. | Approved, Illicit |
| Methapyrilene | The risk or severity of adverse effects can be increased when Promazine is combined with Methapyrilene. | Withdrawn |
| Methaqualone | The risk or severity of adverse effects can be increased when Promazine is combined with Methaqualone. | Illicit, Withdrawn |
| Methocarbamol | The risk or severity of adverse effects can be increased when Promazine is combined with Methocarbamol. | Approved, Vet Approved |
| Methohexital | The risk or severity of adverse effects can be increased when Promazine is combined with Methohexital. | Approved |
| Methotrimeprazine | Promazine may increase the central nervous system depressant (CNS depressant) activities of Methotrimeprazine. | Approved |
| Methoxyflurane | The metabolism of Methoxyflurane can be decreased when combined with Promazine. | Approved, Vet Approved |
| Methsuximide | The risk or severity of adverse effects can be increased when Promazine is combined with Methsuximide. | Approved |
| Methylecgonine | The risk or severity of adverse effects can be increased when Promazine is combined with ECGONINE METHYL ESTER. | Experimental |
| Methylphenidate | The risk or severity of adverse effects can be increased when Promazine is combined with Methylphenidate. | Approved, Investigational |
| Methylphenobarbital | The risk or severity of adverse effects can be increased when Promazine is combined with Methylphenobarbital. | Approved |
| Methyprylon | The metabolism of Methyprylon can be decreased when combined with Promazine. | Approved, Illicit, Withdrawn |
| Metipranolol | Promazine may increase the hypotensive activities of Metipranolol. | Approved |
| Metoclopramide | The risk or severity of adverse effects can be increased when Metoclopramide is combined with Promazine. | Approved, Investigational |
| Metoprolol | The metabolism of Metoprolol can be decreased when combined with Promazine. | Approved, Investigational |
| Metronidazole | Metronidazole may increase the QTc-prolonging activities of Promazine. | Approved |
| Metyrosine | Promazine may increase the sedative activities of Metyrosine. | Approved |
| Mexiletine | The metabolism of Promazine can be decreased when combined with Mexiletine. | Approved |
| Mianserin | The metabolism of Mianserin can be decreased when combined with Promazine. | Approved |
| Midazolam | The risk or severity of adverse effects can be increased when Promazine is combined with Midazolam. | Approved, Illicit |
| Mifepristone | Mifepristone may increase the QTc-prolonging activities of Promazine. | Approved, Investigational |
| Milnacipran | The risk or severity of adverse effects can be increased when Promazine is combined with Milnacipran. | Approved |
| Minaprine | The metabolism of Minaprine can be decreased when combined with Promazine. | Approved |
| Minocycline | Minocycline may increase the central nervous system depressant (CNS depressant) activities of Promazine. | Approved, Investigational |
| Mirabegron | Mirabegron may increase the QTc-prolonging activities of Promazine. | Approved |
| Mirtazapine | Promazine may increase the central nervous system depressant (CNS depressant) activities of Mirtazapine. | Approved |
| Mitotane | The serum concentration of Promazine can be decreased when it is combined with Mitotane. | Approved |
| Mizoribine | The serum concentration of Promazine can be increased when it is combined with Mizoribine. | Investigational |
| MMDA | Promazine may decrease the stimulatory activities of MMDA. | Experimental, Illicit |
| Moclobemide | The metabolism of Moclobemide can be decreased when combined with Promazine. | Approved |
| Modafinil | The serum concentration of Promazine can be decreased when it is combined with Modafinil. | Approved, Investigational |
| Moexipril | Moexipril may increase the QTc-prolonging activities of Promazine. | Approved |
| Molindone | The risk or severity of adverse effects can be increased when Promazine is combined with Molindone. | Approved |
| Morphine | The metabolism of Morphine can be decreased when combined with Promazine. | Approved, Investigational |
| Moxifloxacin | Moxifloxacin may increase the QTc-prolonging activities of Promazine. | Approved, Investigational |
| Nabilone | Nabilone may increase the central nervous system depressant (CNS depressant) activities of Promazine. | Approved, Investigational |
| Nadolol | Promazine may increase the hypotensive activities of Nadolol. | Approved |
| Nafcillin | The serum concentration of Promazine can be decreased when it is combined with Nafcillin. | Approved |
| Nalbuphine | The risk or severity of adverse effects can be increased when Promazine is combined with Nalbuphine. | Approved |
| Naratriptan | The risk or severity of adverse effects can be increased when Naratriptan is combined with Promazine. | Approved, Investigational |
| Nateglinide | The metabolism of Nateglinide can be decreased when combined with Promazine. | Approved, Investigational |
| Nebivolol | The serum concentration of Nebivolol can be increased when it is combined with Promazine. | Approved, Investigational |
| Nefazodone | The metabolism of Promazine can be decreased when combined with Nefazodone. | Approved, Withdrawn |
| Nelfinavir | The metabolism of Promazine can be decreased when combined with Nelfinavir. | Approved |
| Netupitant | The serum concentration of Promazine can be increased when it is combined with Netupitant. | Approved |
| Nevirapine | The metabolism of Promazine can be increased when combined with Nevirapine. | Approved |
| Nicardipine | The metabolism of Promazine can be decreased when combined with Nicardipine. | Approved |
| Nicergoline | The metabolism of Nicergoline can be decreased when combined with Promazine. | Approved |
| Nicotine | The metabolism of Nicotine can be decreased when combined with Promazine. | Approved |
| Nifedipine | The metabolism of Nifedipine can be decreased when combined with Promazine. | Approved |
| Nilotinib | Promazine may increase the QTc-prolonging activities of Nilotinib. | Approved, Investigational |
| Nitrazepam | The risk or severity of adverse effects can be increased when Promazine is combined with Nitrazepam. | Approved |
| Nitrofural | The metabolism of Nitrofural can be decreased when combined with Promazine. | Approved, Vet Approved |
| Nitrous oxide | The risk or severity of adverse effects can be increased when Promazine is combined with Nitrous oxide. | Approved, Vet Approved |
| Norfloxacin | Norfloxacin may increase the QTc-prolonging activities of Promazine. | Approved |
| Norflurane | The risk or severity of adverse effects can be increased when Promazine is combined with 1,1,1,2 Tetrafluoroethane. | Investigational |
| Normethadone | The risk or severity of adverse effects can be increased when Promazine is combined with Normethadone. | Approved, Illicit |
| Nortriptyline | Nortriptyline may increase the QTc-prolonging activities of Promazine. | Approved |
| Octreotide | Octreotide may increase the QTc-prolonging activities of Promazine. | Approved, Investigational |
| Ofloxacin | Promazine may increase the QTc-prolonging activities of Ofloxacin. | Approved |
| Olanzapine | Olanzapine may increase the QTc-prolonging activities of Promazine. | Approved, Investigational |
| Olaparib | The metabolism of Promazine can be decreased when combined with Olaparib. | Approved |
| Olodaterol | Olodaterol may increase the QTc-prolonging activities of Promazine. | Approved |
| Olopatadine | The risk or severity of adverse effects can be increased when Promazine is combined with Olopatadine. | Approved |
| Omeprazole | The metabolism of Promazine can be decreased when combined with Omeprazole. | Approved, Investigational, Vet Approved |
| Ondansetron | Promazine may increase the QTc-prolonging activities of Ondansetron. | Approved |
| Opium | The risk or severity of adverse effects can be increased when Promazine is combined with Opium. | Approved, Illicit |
| Orphenadrine | Promazine may increase the central nervous system depressant (CNS depressant) activities of Orphenadrine. | Approved |
| Osanetant | The risk or severity of adverse effects can be increased when Promazine is combined with Osanetant. | Investigational |
| Osimertinib | The serum concentration of Promazine can be increased when it is combined with Osimertinib. | Approved |
| Oxazepam | The risk or severity of adverse effects can be increased when Promazine is combined with Oxazepam. | Approved |
| Oxethazaine | The risk or severity of adverse effects can be increased when Promazine is combined with Oxetacaine. | Investigational |
| Oxprenolol | The risk or severity of adverse effects can be increased when Promazine is combined with Oxprenolol. | Approved |
| Oxybuprocaine | The risk or severity of adverse effects can be increased when Promazine is combined with Oxybuprocaine. | Approved |
| Oxycodone | The metabolism of Oxycodone can be decreased when combined with Promazine. | Approved, Illicit, Investigational |
| Oxymorphone | The metabolism of Oxymorphone can be decreased when combined with Promazine. | Approved, Investigational, Vet Approved |
| Oxytocin | Oxytocin may increase the QTc-prolonging activities of Promazine. | Approved, Vet Approved |
| Palbociclib | The serum concentration of Promazine can be increased when it is combined with Palbociclib. | Approved |
| Paliperidone | Promazine may increase the QTc-prolonging activities of Paliperidone. | Approved |
| Palonosetron | The metabolism of Palonosetron can be decreased when combined with Promazine. | Approved, Investigational |
| Panobinostat | Promazine may increase the QTc-prolonging activities of Panobinostat. | Approved, Investigational |
| Pantoprazole | The metabolism of Promazine can be decreased when combined with Pantoprazole. | Approved |
| Paraldehyde | Promazine may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde. | Approved |
| Paroxetine | Paroxetine may increase the QTc-prolonging activities of Promazine. | Approved, Investigational |
| Pasireotide | Pasireotide may increase the QTc-prolonging activities of Promazine. | Approved |
| Pazopanib | Promazine may increase the QTc-prolonging activities of Pazopanib. | Approved |
| Peginterferon alfa-2b | The serum concentration of Promazine can be increased when it is combined with Peginterferon alfa-2b. | Approved |
| Penbutolol | Promazine may increase the hypotensive activities of Penbutolol. | Approved, Investigational |
| Pentamidine | Promazine may increase the QTc-prolonging activities of Pentamidine. | Approved |
| Pentazocine | The risk or severity of adverse effects can be increased when Promazine is combined with Pentazocine. | Approved, Vet Approved |
| Pentobarbital | The metabolism of Promazine can be increased when combined with Pentobarbital. | Approved, Vet Approved |
| Perampanel | Perampanel may increase the central nervous system depressant (CNS depressant) activities of Promazine. | Approved |
| Perazine | The risk or severity of adverse effects can be increased when Promazine is combined with Perazine. | Investigational |
| Perflutren | Promazine may increase the QTc-prolonging activities of Perflutren. | Approved |
| Perhexiline | The metabolism of Perhexiline can be decreased when combined with Promazine. | Approved |
| Perospirone | The risk or severity of adverse effects can be increased when Promazine is combined with Perospirone. | Approved |
| Perphenazine | The metabolism of Perphenazine can be decreased when combined with Promazine. | Approved |
| Pethidine | The metabolism of Pethidine can be decreased when combined with Promazine. | Approved |
| Phenacetin | The metabolism of Phenacetin can be decreased when combined with Promazine. | Withdrawn |
| Phenelzine | The risk or severity of adverse effects can be increased when Phenelzine is combined with Promazine. | Approved |
| Phenformin | The metabolism of Phenformin can be decreased when combined with Promazine. | Approved, Withdrawn |
| Phenobarbital | The metabolism of Promazine can be increased when combined with Phenobarbital. | Approved |
| Phentermine | Promazine may decrease the stimulatory activities of Phentermine. | Approved, Illicit |
| Phenytoin | The metabolism of Promazine can be increased when combined with Phenytoin. | Approved, Vet Approved |
| Pimozide | Promazine may increase the QTc-prolonging activities of Pimozide. | Approved |
| Pindolol | The metabolism of Pindolol can be decreased when combined with Promazine. | Approved |
| Pipamperone | The risk or severity of adverse effects can be increased when Promazine is combined with Pipamperone. | Approved |
| Piperazine | The metabolism of Piperazine can be decreased when combined with Promazine. | Approved, Vet Approved |
| Pipotiazine | The metabolism of Pipotiazine can be decreased when combined with Promazine. | Approved |
| Piribedil | The therapeutic efficacy of Promazine can be decreased when used in combination with Piribedil. | Investigational |
| Piritramide | The risk or severity of adverse effects can be increased when Promazine is combined with Piritramide. | Investigational |
| Pomalidomide | The risk or severity of adverse effects can be increased when Promazine is combined with Pomalidomide. | Approved |
| Ponatinib | The metabolism of Ponatinib can be decreased when combined with Promazine. | Approved |
| Posaconazole | The metabolism of Promazine can be decreased when combined with Posaconazole. | Approved, Investigational, Vet Approved |
| Practolol | Promazine may increase the hypotensive activities of Practolol. | Approved |
| Pramipexole | Promazine may increase the sedative activities of Pramipexole. | Approved, Investigational |
| Pramocaine | The risk or severity of adverse effects can be increased when Promazine is combined with Pramocaine. | Approved |
| Prazepam | The risk or severity of adverse effects can be increased when Promazine is combined with Prazepam. | Approved, Illicit |
| Pregabalin | The risk or severity of adverse effects can be increased when Pregabalin is combined with Promazine. | Approved, Illicit, Investigational |
| Prilocaine | The risk or severity of adverse effects can be increased when Promazine is combined with Prilocaine. | Approved |
| Primaquine | Promazine may increase the QTc-prolonging activities of Primaquine. | Approved |
| Primidone | The metabolism of Promazine can be increased when combined with Primidone. | Approved, Vet Approved |
| Procainamide | Promazine may increase the QTc-prolonging activities of Procainamide. | Approved |
| Procaine | The risk or severity of adverse effects can be increased when Promazine is combined with Procaine. | Approved, Investigational, Vet Approved |
| Procarbazine | The risk or severity of adverse effects can be increased when Procarbazine is combined with Promazine. | Approved |
| Prochlorperazine | The metabolism of Prochlorperazine can be decreased when combined with Promazine. | Approved, Vet Approved |
| Progesterone | The metabolism of Progesterone can be decreased when combined with Promazine. | Approved, Vet Approved |
| Proguanil | The serum concentration of Promazine can be increased when it is combined with Proguanil. | Approved |
| Promethazine | Promethazine may increase the QTc-prolonging activities of Promazine. | Approved |
| Propafenone | The serum concentration of Promazine can be increased when it is combined with Propafenone. | Approved |
| Proparacaine | The risk or severity of adverse effects can be increased when Promazine is combined with Proparacaine. | Approved, Vet Approved |
| Propofol | Propofol may increase the QTc-prolonging activities of Promazine. | Approved, Investigational, Vet Approved |
| Propoxycaine | The risk or severity of adverse effects can be increased when Promazine is combined with Propoxycaine. | Approved |
| Propranolol | The metabolism of Propranolol can be decreased when combined with Promazine. | Approved, Investigational |
| Protriptyline | Protriptyline may increase the QTc-prolonging activities of Promazine. | Approved |
| Pseudoephedrine | The metabolism of Pseudoephedrine can be decreased when combined with Promazine. | Approved |
| Pyrimethamine | The serum concentration of Promazine can be increased when it is combined with Pyrimethamine. | Approved, Vet Approved |
| Pyronaridine | The serum concentration of Promazine can be increased when it is combined with Pyronaridine. | Investigational |
| Quazepam | The risk or severity of adverse effects can be increased when Promazine is combined with Quazepam. | Approved, Illicit |
| Quetiapine | Promazine may increase the QTc-prolonging activities of Quetiapine. | Approved |
| Quinacrine | The serum concentration of Promazine can be increased when it is combined with Quinacrine. | Approved |
| Quinagolide | The therapeutic efficacy of Quinagolide can be decreased when used in combination with Promazine. | Approved |
| Quinidine | Promazine may increase the QTc-prolonging activities of Quinidine. | Approved |
| Quinine | Promazine may increase the QTc-prolonging activities of Quinine. | Approved |
| Raclopride | The risk or severity of adverse effects can be increased when Promazine is combined with Raclopride. | Investigational |
| Radicicol | The serum concentration of Promazine can be increased when it is combined with Radicicol. | Experimental |
| Ramelteon | The risk or severity of adverse effects can be increased when Promazine is combined with Ramelteon. | Approved, Investigational |
| Ranitidine | The metabolism of Ranitidine can be decreased when combined with Promazine. | Approved |
| Ranolazine | Ranolazine may increase the QTc-prolonging activities of Promazine. | Approved, Investigational |
| Rasagiline | The risk or severity of adverse effects can be increased when Rasagiline is combined with Promazine. | Approved |
| Remifentanil | The risk or severity of adverse effects can be increased when Promazine is combined with Remifentanil. | Approved |
| Remoxipride | The metabolism of Remoxipride can be decreased when combined with Promazine. | Approved, Withdrawn |
| Reserpine | The risk or severity of adverse effects can be increased when Reserpine is combined with Promazine. | Approved |
| Rifabutin | The metabolism of Promazine can be increased when combined with Rifabutin. | Approved |
| Rifampicin | The metabolism of Promazine can be increased when combined with Rifampicin. | Approved |
| Rifapentine | The metabolism of Promazine can be increased when combined with Rifapentine. | Approved |
| Rilpivirine | Rilpivirine may increase the QTc-prolonging activities of Promazine. | Approved |
| Risperidone | Risperidone may increase the QTc-prolonging activities of Promazine. | Approved, Investigational |
| Ritanserin | The risk or severity of adverse effects can be increased when Promazine is combined with Ritanserin. | Investigational |
| Ritobegron | Promazine may decrease the stimulatory activities of Ritobegron. | Investigational |
| Ritonavir | The metabolism of Promazine can be decreased when combined with Ritonavir. | Approved, Investigational |
| Rizatriptan | The risk or severity of adverse effects can be increased when Rizatriptan is combined with Promazine. | Approved |
| Ropinirole | Promazine may increase the sedative activities of Ropinirole. | Approved, Investigational |
| Ropivacaine | The metabolism of Ropivacaine can be decreased when combined with Promazine. | Approved |
| Rotigotine | Promazine may increase the sedative activities of Rotigotine. | Approved |
| Rufinamide | The risk or severity of adverse effects can be increased when Rufinamide is combined with Promazine. | Approved |
| Salbutamol | Salbutamol may increase the QTc-prolonging activities of Promazine. | Approved, Vet Approved |
| Salmeterol | Salmeterol may increase the QTc-prolonging activities of Promazine. | Approved |
| Saquinavir | Promazine may increase the QTc-prolonging activities of Saquinavir. | Approved, Investigational |
| Scopolamine | The risk or severity of adverse effects can be increased when Promazine is combined with Scopolamine. | Approved |
| Secobarbital | The metabolism of Promazine can be increased when combined with Secobarbital. | Approved, Vet Approved |
| Selegiline | The risk or severity of adverse effects can be increased when Selegiline is combined with Promazine. | Approved, Investigational, Vet Approved |
| Sepranolone | The risk or severity of adverse effects can be increased when Promazine is combined with Uc1010. | Investigational |
| Sertindole | The metabolism of Sertindole can be decreased when combined with Promazine. | Approved, Withdrawn |
| Sertraline | Sertraline may increase the QTc-prolonging activities of Promazine. | Approved |
| Sevoflurane | Sevoflurane may increase the QTc-prolonging activities of Promazine. | Approved, Vet Approved |
| Sildenafil | The metabolism of Promazine can be decreased when combined with Sildenafil. | Approved, Investigational |
| Siltuximab | The serum concentration of Promazine can be decreased when it is combined with Siltuximab. | Approved |
| Simeprevir | The serum concentration of Promazine can be increased when it is combined with Simeprevir. | Approved |
| Simvastatin | The metabolism of Simvastatin can be decreased when combined with Promazine. | Approved |
| Sinefungin | The serum concentration of Promazine can be increased when it is combined with Sinefungin. | Experimental |
| Sodium oxybate | Sodium oxybate may increase the central nervous system depressant (CNS depressant) activities of Promazine. | Approved |
| Solifenacin | Solifenacin may increase the QTc-prolonging activities of Promazine. | Approved |
| Sorafenib | Sorafenib may increase the QTc-prolonging activities of Promazine. | Approved, Investigational |
| Sotalol | Promazine may increase the QTc-prolonging activities of Sotalol. | Approved |
| Sparteine | The metabolism of Sparteine can be decreased when combined with Promazine. | Experimental |
| St. John's Wort | The serum concentration of Promazine can be decreased when it is combined with St. John's Wort. | Nutraceutical |
| Stiripentol | The serum concentration of Promazine can be increased when it is combined with Stiripentol. | Approved |
| Sufentanil | The risk or severity of adverse effects can be increased when Promazine is combined with Sufentanil. | Approved, Investigational |
| Sulfadiazine | The metabolism of Promazine can be decreased when combined with Sulfadiazine. | Approved, Vet Approved |
| Sulfadoxine | The serum concentration of Promazine can be increased when it is combined with Sulfadoxine. | Approved |
| Sulfamethoxazole | Sulfamethoxazole may increase the QTc-prolonging activities of Promazine. | Approved |
| Sulfametopyrazine | The serum concentration of Promazine can be increased when it is combined with Sulfametopyrazine. | Approved, Withdrawn |
| Sulfisoxazole | Sulfisoxazole may increase the QTc-prolonging activities of Promazine. | Approved, Vet Approved |
| Sulpiride | The risk or severity of adverse effects can be increased when Promazine is combined with Sulpiride. | Approved |
| Sumatriptan | The risk or severity of adverse effects can be increased when Sumatriptan is combined with Promazine. | Approved, Investigational |
| Sunitinib | Sunitinib may increase the QTc-prolonging activities of Promazine. | Approved, Investigational |
| Suvorexant | Promazine may increase the central nervous system depressant (CNS depressant) activities of Suvorexant. | Approved |
| Tamoxifen | The serum concentration of the active metabolites of Tamoxifen can be reduced when Tamoxifen is used in combination with Promazine resulting in a loss in efficacy. | Approved |
| Tamsulosin | The metabolism of Tamsulosin can be decreased when combined with Promazine. | Approved, Investigational |
| Tandospirone | The risk or severity of adverse effects can be increased when Promazine is combined with Tandospirone. | Investigational |
| Tapentadol | Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Promazine. | Approved |
| Tasimelteon | The risk or severity of adverse effects can be increased when Promazine is combined with Tasimelteon. | Approved |
| Tedizolid Phosphate | The risk or severity of adverse effects can be increased when Tedizolid Phosphate is combined with Promazine. | Approved |
| Tegaserod | The metabolism of Tegaserod can be decreased when combined with Promazine. | Investigational, Withdrawn |
| Telaprevir | The metabolism of Promazine can be decreased when combined with Telaprevir. | Withdrawn |
| Telavancin | Promazine may increase the QTc-prolonging activities of Telavancin. | Approved |
| Telithromycin | Promazine may increase the QTc-prolonging activities of Telithromycin. | Approved |
| Temazepam | The risk or severity of adverse effects can be increased when Temazepam is combined with Promazine. | Approved |
| Tenofovir disoproxil | The metabolism of Promazine can be decreased when combined with Tenofovir. | Approved, Investigational |
| Terbutaline | Terbutaline may increase the QTc-prolonging activities of Promazine. | Approved |
| Terfenadine | The metabolism of Terfenadine can be decreased when combined with Promazine. | Withdrawn |
| Teriflunomide | The serum concentration of Promazine can be decreased when it is combined with Teriflunomide. | Approved |
| Tesmilifene | The metabolism of Tesmilifene can be decreased when combined with Promazine. | Investigational |
| Tetrabenazine | The risk or severity of adverse effects can be increased when Tetrabenazine is combined with Promazine. | Approved |
| Tetracaine | The risk or severity of adverse effects can be increased when Promazine is combined with Tetracaine. | Approved, Vet Approved |
| Tetrodotoxin | The risk or severity of adverse effects can be increased when Promazine is combined with Tetrodotoxin. | Investigational |
| Thalidomide | Promazine may increase the central nervous system depressant (CNS depressant) activities of Thalidomide. | Approved, Investigational, Withdrawn |
| Theophylline | The metabolism of Promazine can be decreased when combined with Theophylline. | Approved |
| Thiamylal | The risk or severity of adverse effects can be increased when Promazine is combined with Thiamylal. | Approved, Vet Approved |
| Thiopental | The risk or severity of adverse effects can be increased when Promazine is combined with Thiopental. | Approved, Vet Approved |
| Thioridazine | Promazine may increase the QTc-prolonging activities of Thioridazine. | Withdrawn |
| Thiothixene | Thiothixene may increase the QTc-prolonging activities of Promazine. | Approved |
| Tiagabine | The risk or severity of adverse effects can be increased when Promazine is combined with Tiagabine. | Approved |
| Tiapride | The risk or severity of adverse effects can be increased when Promazine is combined with Tiapride. | Approved, Investigational |
| Ticagrelor | The metabolism of Promazine can be decreased when combined with Ticagrelor. | Approved |
| Ticlopidine | The metabolism of Promazine can be decreased when combined with Ticlopidine. | Approved |
| Timolol | The metabolism of Timolol can be decreased when combined with Promazine. | Approved |
| Tiotropium | The metabolism of Tiotropium can be decreased when combined with Promazine. | Approved |
| Tipranavir | The metabolism of Tipranavir can be decreased when combined with Promazine. | Approved, Investigational |
| Tizanidine | Tizanidine may increase the QTc-prolonging activities of Promazine. | Approved |
| Tocilizumab | The serum concentration of Promazine can be decreased when it is combined with Tocilizumab. | Approved |
| Tolbutamide | The metabolism of Promazine can be decreased when combined with Tolbutamide. | Approved |
| Tolcapone | The risk or severity of adverse effects can be increased when Promazine is combined with Tolcapone. | Approved, Withdrawn |
| Tolterodine | Tolterodine may increase the QTc-prolonging activities of Promazine. | Approved, Investigational |
| Topiramate | The risk or severity of adverse effects can be increased when Promazine is combined with Topiramate. | Approved |
| Toremifene | Promazine may increase the QTc-prolonging activities of Toremifene. | Approved, Investigational |
| Trabectedin | The metabolism of Trabectedin can be decreased when combined with Promazine. | Approved, Investigational |
| Tramadol | The therapeutic efficacy of Tramadol can be decreased when used in combination with Promazine. | Approved, Investigational |
| Trans-2-Phenylcyclopropylamine | The risk or severity of adverse effects can be increased when Promazine is combined with Trans-2-Phenylcyclopropylamine. | Experimental |
| Tranylcypromine | The risk or severity of adverse effects can be increased when Promazine is combined with Tranylcypromine. | Approved |
| Trazodone | Trazodone may increase the QTc-prolonging activities of Promazine. | Approved, Investigational |
| Treprostinil | Treprostinil may increase the QTc-prolonging activities of Promazine. | Approved, Investigational |
| Triazolam | The risk or severity of adverse effects can be increased when Promazine is combined with Triazolam. | Approved |
| Trifluoperazine | The risk or severity of adverse effects can be increased when Promazine is combined with Trifluoperazine. | Approved |
| Triflupromazine | The risk or severity of adverse effects can be increased when Promazine is combined with Triflupromazine. | Approved, Vet Approved |
| Trimethoprim | The serum concentration of Promazine can be increased when it is combined with Trimethoprim. | Approved, Vet Approved |
| Trimipramine | Trimipramine may increase the QTc-prolonging activities of Promazine. | Approved |
| Triprolidine | The risk or severity of adverse effects can be increased when Promazine is combined with Triprolidine. | Approved |
| Triptorelin | Triptorelin may increase the QTc-prolonging activities of Promazine. | Approved, Vet Approved |
| Umeclidinium | The metabolism of Umeclidinium can be decreased when combined with Promazine. | Approved |
| Valproic Acid | The risk or severity of adverse effects can be increased when Valproic Acid is combined with Promazine. | Approved, Investigational |
| Valsartan | The metabolism of Promazine can be decreased when combined with Valsartan. | Approved, Investigational |
| Vandetanib | Promazine may increase the QTc-prolonging activities of Vandetanib. | Approved |
| Vardenafil | Vardenafil may increase the QTc-prolonging activities of Promazine. | Approved |
| Vemurafenib | The serum concentration of Promazine can be increased when it is combined with Vemurafenib. | Approved |
| Venlafaxine | Venlafaxine may increase the QTc-prolonging activities of Promazine. | Approved |
| Verapamil | The metabolism of Promazine can be decreased when combined with Verapamil. | Approved |
| Vigabatrin | The risk or severity of adverse effects can be increased when Promazine is combined with Vigabatrin. | Approved |
| Vilanterol | Vilanterol may increase the QTc-prolonging activities of Promazine. | Approved |
| Vilazodone | The metabolism of Vilazodone can be decreased when combined with Promazine. | Approved |
| Vinblastine | The metabolism of Vinblastine can be decreased when combined with Promazine. | Approved |
| Vinorelbine | The metabolism of Vinorelbine can be decreased when combined with Promazine. | Approved, Investigational |
| Voriconazole | The metabolism of Promazine can be decreased when combined with Voriconazole. | Approved, Investigational |
| Vorinostat | Vorinostat may increase the QTc-prolonging activities of Promazine. | Approved, Investigational |
| Vortioxetine | The metabolism of Vortioxetine can be decreased when combined with Promazine. | Approved |
| Yohimbine | The metabolism of Yohimbine can be decreased when combined with Promazine. | Approved, Vet Approved |
| Zafirlukast | The metabolism of Promazine can be decreased when combined with Zafirlukast. | Approved, Investigational |
| Zalcitabine | The metabolism of Zalcitabine can be decreased when combined with Promazine. | Approved |
| Zaleplon | The risk or severity of adverse effects can be increased when Promazine is combined with Zaleplon. | Approved, Illicit, Investigational |
| Ziconotide | The risk or severity of adverse effects can be increased when Promazine is combined with Ziconotide. | Approved |
| Zimelidine | The risk or severity of adverse effects can be increased when Promazine is combined with Zimelidine. | Withdrawn |
| Ziprasidone | Promazine may increase the QTc-prolonging activities of Ziprasidone. | Approved |
| Zolmitriptan | The risk or severity of adverse effects can be increased when Zolmitriptan is combined with Promazine. | Approved, Investigational |
| Zolpidem | Promazine may increase the central nervous system depressant (CNS depressant) activities of Zolpidem. | Approved |
| Zonisamide | The risk or severity of adverse effects can be increased when Promazine is combined with Zonisamide. | Approved, Investigational |
| Zopiclone | The risk or severity of adverse effects can be increased when Promazine is combined with Zopiclone. | Approved |
| Zotepine | The risk or severity of adverse effects can be increased when Promazine is combined with Zotepine. | Approved |
| Zuclopenthixol | Promazine may increase the QTc-prolonging activities of Zuclopenthixol. | Approved, Investigational |
