Displaying drugs 276 - 300 of 11740 in total
Calcitriol
Calcitriol is an active metabolite of vitamin D with 3 hydroxyl (OH) groups and is commonly referred to as 1,25-dihydroxycholecalciferol, or 1alpha,25-dihydroxyvitamin D3, 1,25-dihydroxyvitamin D3. It is produced in the body after series of conversion steps of 7-dehydrocholesterol from exposure to UV light. 7-dehydrocholesterol is converted to DB00169 (vitamin D3)...
Approved
Nutraceutical
Matched Description: … is modulated by signaling pathways of classical nuclear receptors (nVDR), where calcitriol acts as a ... Administered orally and intravenously, calcitriol is commonly used as a medication in the treatment of ... Calcitriol plays a role in plasma calcium regulation in concert with parathyroid hormone (PTH) by enhancing …
Flavone
Approved
Experimental
Atriplex canescens pollen
Atriplex canescens pollen is the pollen of the Atriplex canescens plant. Atriplex canescens pollen is mainly used in allergenic testing.
Approved
Fenpropidin
Fenpropidin has been investigated for the treatment of Hernia.
Approved
Experimental
Matched Categories: … Compounds used in a research, industrial, or household setting …
Gestrinone
Gestrinone, also known as ethylnorgestrienone, is a synthetic steroid of the 19-nortestosterone group that is marketed in Europe, Australia, and Latin America, though not the United States or Canada, and is used primarily in the treatment of endometriosis.
Gestrinone was developed in the early 1970s and was tested clinically as...
Approved
Matched Iupac: … (1R,3aS,3bS,11aS)-11a-ethyl-1-ethynyl-1-hydroxy-1H,2H,3H,3aH,3bH,4H,5H,7H,8H,9H,11aH-cyclopenta[a]phenanthren …
Matched Description: … Gestrinone, also known as ethylnorgestrienone, is a synthetic steroid of the 19-nortestosterone group ... Gestrinone was developed in the early 1970s and was tested clinically as a weekly oral contraceptive …
Matched Description: … Gestrinone, also known as ethylnorgestrienone, is a synthetic steroid of the 19-nortestosterone group ... Gestrinone was developed in the early 1970s and was tested clinically as a weekly oral contraceptive …
Estradiol acetate
Estradiol acetate is a pro-drug ester of DB00783, a naturally occurring hormone that circulates endogenously within the human body. Estradiol is the most potent form of all mammalian estrogenic steroids and acts as the major female sex hormone. As a pro-drug of estradiol, estradiol acetate therefore has the same downstream...
Approved
Investigational
Vet approved
Matched Iupac: … (1S,3aS,3bR,9bS,11aS)-1-hydroxy-11a-methyl-1H,2H,3H,3aH,3bH,4H,5H,9bH,10H,11H,11aH-cyclopenta[a]phenanthren …
Matched Description: … Estradiol acetate is a pro-drug ester of [DB00783], a naturally occurring hormone that circulates endogenously ... As a pro-drug of estradiol, estradiol acetate therefore has the same downstream effects within the body ... First-pass metabolism by the gut and the liver quickly degrades the estradiol molecule before it gets a …
Matched Description: … Estradiol acetate is a pro-drug ester of [DB00783], a naturally occurring hormone that circulates endogenously ... As a pro-drug of estradiol, estradiol acetate therefore has the same downstream effects within the body ... First-pass metabolism by the gut and the liver quickly degrades the estradiol molecule before it gets a …
Estradiol benzoate
Estradiol Benzoate is a pro-drug ester of DB00783, a naturally occurring hormone that circulates endogenously within the human body. Estradiol is the most potent form of all mammalian estrogenic steroids and acts as the major female sex hormone. As a pro-drug of estradiol, estradiol benzoate therefore has the same downstream...
Approved
Investigational
Vet approved
Matched Iupac: … (1S,3aS,3bR,9bS,11aS)-1-hydroxy-11a-methyl-1H,2H,3H,3aH,3bH,4H,5H,9bH,10H,11H,11aH-cyclopenta[a]phenanthren …
Matched Description: … Estradiol Benzoate is a pro-drug ester of [DB00783], a naturally occurring hormone that circulates endogenously ... As a pro-drug of estradiol, estradiol benzoate therefore has the same downstream effects within the body ... First-pass metabolism by the gut and the liver quickly degrades the estradiol molecule before it gets a …
Matched Description: … Estradiol Benzoate is a pro-drug ester of [DB00783], a naturally occurring hormone that circulates endogenously ... As a pro-drug of estradiol, estradiol benzoate therefore has the same downstream effects within the body ... First-pass metabolism by the gut and the liver quickly degrades the estradiol molecule before it gets a …
Estrone sulfate
Estrone sulfate (as estropipate) is a form of estrogen. It has several uses such as: alleviate symptoms of menopause as hormone replacement therapy, treatment some types of infertility, treatment of some conditions leading to underdevelopment of female sexual characteristics, treatment of vaginal atrophy, treatment of some types of breast cancer...
Approved
Matched Iupac: … [(3aS,3bR,9bS,11aS)-11a-methyl-1-oxo-1H,2H,3H,3aH,3bH,4H,5H,9bH,10H,11H,11aH-cyclopenta[a]phenanthren …
Matched Description: … Estrone sulfate (as estropipate) is a form of estrogen. …
Matched Description: … Estrone sulfate (as estropipate) is a form of estrogen. …
Estradiol valerate
Estradiol Valerate (also known as E2V) is a pro-drug ester of DB00783, a naturally occurring hormone that circulates endogenously within the human body. Estradiol is the most potent form of all mammalian estrogenic steroids and acts as the major female sex hormone. As a pro-drug of estradiol, estradiol acetate therefore...
Approved
Investigational
Vet approved
Matched Iupac: … (1S,3aS,3bR,9bS,11aS)-7-hydroxy-11a-methyl-1H,2H,3H,3aH,3bH,4H,5H,9bH,10H,11H,11aH-cyclopenta[a]phenanthren …
Matched Description: … Estradiol Valerate (also known as E2V) is a pro-drug ester of [DB00783], a naturally occurring hormone ... As a pro-drug of estradiol, estradiol acetate therefore has the same downstream effects within the body ... First-pass metabolism by the gut and the liver quickly degrades the estradiol molecule before it gets a …
Matched Description: … Estradiol Valerate (also known as E2V) is a pro-drug ester of [DB00783], a naturally occurring hormone ... As a pro-drug of estradiol, estradiol acetate therefore has the same downstream effects within the body ... First-pass metabolism by the gut and the liver quickly degrades the estradiol molecule before it gets a …
Isosulfan blue
Approved
Matched Categories: … Compounds used in a research, industrial, or household setting …
Tannic acid
Tannic acid is a polyphenolic compound. It is a type of the commercially available tannins. It acts as a weak acid. Tannic acid is found in the nutgalls formed by insects on twigs of certain oak trees (Quercus infectoria and other Quercus species). It is removed and used as medicine....
Approved
Matched Description: … It acts as a weak acid. ... Tannic acid is a polyphenolic compound. It is a type of the commercially available tannins. …
Matched Categories: … Compounds used in a research, industrial, or household setting …
Matched Categories: … Compounds used in a research, industrial, or household setting …
Edetic acid
A chelating agent (chelating agents) that sequesters a variety of polyvalent cations. It is used in pharmaceutical manufacturing and as a food additive.
Approved
Vet approved
Matched Description: … A chelating agent (chelating agents) that sequesters a variety of polyvalent cations. ... It is used in pharmaceutical manufacturing and as a food additive. …
Matched Categories: … Compounds used in a research, industrial, or household setting …
Matched Categories: … Compounds used in a research, industrial, or household setting …
Potassium bicarbonate
Potassium bicarbonate is a white, crystalline, slightly alkaline and salty substance. It is produced by the passage of carbon dioxide through an aqueous potassium carbonate solution. It is used in medicine as an antacid. It is registered in the FDA under the section of suitable, safe and effective ingredients for...
Approved
Matched Description: … Potassium bicarbonate is a white, crystalline, slightly alkaline and salty substance. ... [L1836] This FDA denomination classifies potassium bicarbonate as a GRAS ingredient.[L1837] …
Mestranol
The 3-methyl ether of ethinyl estradiol. It must be demethylated to be biologically active. It is used as the estrogen component of many combination ORAL contraceptives.
Approved
Matched Iupac: … 3aS,3bR,9bS,11aS)-1-ethynyl-7-methoxy-11a-methyl-1H,2H,3H,3aH,3bH,4H,5H,9bH,10H,11H,11aH-cyclopenta[a] …
Estradiol cypionate
Estradiol Cypionate is a pro-drug ester of DB00783, a naturally occurring hormone that circulates endogenously within the human body. Estradiol is the most potent form of all mammalian estrogenic steroids and acts as the major female sex hormone. As a pro-drug of estradiol, estradiol cypionate therefore has the same downstream...
Approved
Investigational
Vet approved
Matched Iupac: … (1S,3aS,3bR,9bS,11aS)-7-hydroxy-11a-methyl-1H,2H,3H,3aH,3bH,4H,5H,9bH,10H,11H,11aH-cyclopenta[a]phenanthren …
Matched Description: … Estradiol Cypionate is a pro-drug ester of [DB00783], a naturally occurring hormone that circulates endogenously ... As a pro-drug of estradiol, estradiol cypionate therefore has the same downstream effects within the ... First-pass metabolism by the gut and the liver quickly degrades the estradiol molecule before it gets a …
Matched Description: … Estradiol Cypionate is a pro-drug ester of [DB00783], a naturally occurring hormone that circulates endogenously ... As a pro-drug of estradiol, estradiol cypionate therefore has the same downstream effects within the ... First-pass metabolism by the gut and the liver quickly degrades the estradiol molecule before it gets a …
Dalfampridine
Dalfampridine is a potassium channel blocker used to help multiple sclerosis patients walk. This is the first drug that was specifically approved to help with mobility in these patients. FDA approved on January 22, 2010.
Approved
Matched Description: … Dalfampridine is a potassium channel blocker used to help multiple sclerosis patients walk. …
Matched Categories: … OCT2 Substrates with a Narrow Therapeutic Index ... Cytochrome P-450 CYP2E1 Substrates with a Narrow Therapeutic Index …
Matched Categories: … OCT2 Substrates with a Narrow Therapeutic Index ... Cytochrome P-450 CYP2E1 Substrates with a Narrow Therapeutic Index …
Solriamfetol
Solriamfetol marketed under the brand name Sunosi by Jazz Pharmaceuticals in the United States is a dopamine and norepinephrine reuptake inhibitor (DNRI) indicated in treating daytime sleepiness associated with narcolepsy or obstructive sleep apnea[FDA Label]. Solriamfetol was given FDA approval in 2019[FDA Label].
Approved
Matched Description: … Solriamfetol marketed under the brand name Sunosi by Jazz Pharmaceuticals in the United States is a dopamine …
Baricitinib
Baricitinib is a Janus kinase (JAK) inhibitor. JAKs are tyrosine protein kinases that play an important role in pro-inflammatory signaling pathways. Overactive JAKs have been implicated in autoimmune disorders, such as rheumatoid arthritis. By inhibiting the actions of JAK1 and JAK2, baricitinib attenuates JAK-mediated inflammation and immune responses. Baricitinib was...
Approved
Investigational
Matched Description: … Baricitinib is a Janus kinase (JAK) inhibitor. ... [A248405] While baricitinib was granted emergency use as a treatment for COVID-19 in combination with …
Matched Categories: … MATE 2 Substrates with a Narrow Therapeutic Index ... OAT3/SLC22A8 Substrates with a Narrow Therapeutic Index ... P-glycoprotein substrates with a Narrow Therapeutic Index ... Cytochrome P-450 CYP3A4 Substrates with a Narrow Therapeutic Index …
Matched Categories: … MATE 2 Substrates with a Narrow Therapeutic Index ... OAT3/SLC22A8 Substrates with a Narrow Therapeutic Index ... P-glycoprotein substrates with a Narrow Therapeutic Index ... Cytochrome P-450 CYP3A4 Substrates with a Narrow Therapeutic Index …
Dacomitinib
Dacomitinib, designed as (2E)-N-16-4-(piperidin-1-yl) but-2-enamide, is an oral highly selective quinazalone part of the second-generation tyrosine kinase inhibitors which are characterized by the irreversible binding at the ATP domain of the epidermal growth factor receptor family kinase domains. Dacomitinib was developed by Pfizer Inc and approved by the FDA on...
Approved
Investigational
Matched Categories: … P-glycoprotein substrates with a Narrow Therapeutic Index ... Cytochrome P-450 CYP2C9 Substrates with a Narrow Therapeutic Index ... Cytochrome P-450 CYP2D6 Substrates with a Narrow Therapeutic Index ... Cytochrome P-450 CYP3A4 Substrates with a Narrow Therapeutic Index …
Dutasteride
Dutasteride is an oral synthetic 4-azasteroid commonly marketed under the trade name Avodart. It is a novel dual 5α-reductase inhibitor that works by blocking both isoforms of 5α-reductase enzymes in a potent, selective, and irreversible manner. Type I and II 5α-reductase enzymes convert testosterone into dihydrotestosterone (DHT), a primary hormonal...
Approved
Investigational
Matched Description: … in a potent, selective, and irreversible manner. ... hormonal mediator that plays a role in the development and enlargement of the prostate gland. ... It is a novel dual 5α-reductase inhibitor that works by blocking both isoforms of 5α-reductase enzymes …
Oseltamivir
Oseltamivir (marketed as the product TamifluⓇ), is an antiviral neuraminidase inhibitor used for the treatment and prophylaxis of infection with influenza viruses A (including pandemic H1N1) and B. Oseltamivir exerts its antiviral activity by inhibiting the activity of the viral neuraminidase enzyme found on the surface of the virus, which...
Approved
Matched Description: … "core" drug to a "complementary" drug, due to limited cost-effectiveness. ... neuraminidase inhibitor used for the treatment and prophylaxis of infection with influenza viruses A ... [L7264]
The benefits of oseltamivir use are controversial; a 2014 Cochrane Review of the evidence …
Drometrizole trisiloxane
Drometrizole trisiloxane is a photostable UVA and UVB light filter [A33069, L2780, L2781, L2782, L2783, F81]. The compound is a lipophilic benzotriazole derivative marketed as Meroxyl XL by L'Oreal, although sunscreens with drometrizole trisiloxane are currently only approved for use in the EU, Canada, Australia, and Japan, among other countries....
Approved
Matched Description: … Drometrizole trisiloxane is a photostable UVA and UVB light filter [A33069, L2780, L2781, L2782, L2783 ... The compound is a lipophilic benzotriazole derivative marketed as Meroxyl XL by L'Oreal, although sunscreens …
Matched Categories: … Compounds used in a research, industrial, or household setting …
Matched Categories: … Compounds used in a research, industrial, or household setting …
Artemisia californica pollen
Artemisia californica pollen is the pollen of the Artemisia californica plant. Artemisia californica pollen is mainly used in allergenic testing.
Approved
Niraparib
Niraparib is an orally active poly (ADP-ribose) polymerase (PARP) inhibitor. By blocking the enzymes responsible for DNA repair, niraparib induces cytotoxicity in cancer cells. Niraparib is selective towards PARP-1 and PARP-2. First approved by the FDA on March 27, 2017, niraparib is used to treat epithelial ovarian, fallopian tube, or...
Approved
Investigational
Matched Categories: … MATE 1 Substrates with a Narrow Therapeutic Index ... MATE 2 Substrates with a Narrow Therapeutic Index ... P-glycoprotein substrates with a Narrow Therapeutic Index …
Dasatinib
Dasatinib is an orally available multikinase inhibitor indicated for the treatment of Philadelphia chromosome (Ph)-positive leukemias.[A2224,L45171] Ph is a chromosomal abnormality found in patients with chronic myelogenous leukemia (CML) and acute lymphocytic leukemia (ALL), where the ABL tyrosine kinase and the breakpoint cluster region (BCR) gene transcribe the chimeric protein...
Approved
Investigational
Matched Description: … [A2224,L45171] Ph is a chromosomal abnormality found in patients with chronic myelogenous leukemia (CML ... not interact with some of the residues involved in those mutations, the use of this drug represents a ... [A11377,A33432] Dasatinib also inhibits a spectrum of kinases involved in cancer, including several SRC-family …
Matched Categories: … P-glycoprotein substrates with a Narrow Therapeutic Index ... Cytochrome P-450 CYP1A2 Substrates with a Narrow Therapeutic Index ... Cytochrome P-450 CYP3A4 Substrates with a Narrow Therapeutic Index ... Cytochrome P-450 CYP3A5 Substrates with a Narrow Therapeutic Index …
Matched Categories: … P-glycoprotein substrates with a Narrow Therapeutic Index ... Cytochrome P-450 CYP1A2 Substrates with a Narrow Therapeutic Index ... Cytochrome P-450 CYP3A4 Substrates with a Narrow Therapeutic Index ... Cytochrome P-450 CYP3A5 Substrates with a Narrow Therapeutic Index …
Displaying drugs 276 - 300 of 11740 in total