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Identification
NameEdetic Acid
Accession NumberDB00974  (APRD01327)
TypeSmall Molecule
GroupsApproved, Vet Approved
DescriptionA chelating agent (chelating agents) that sequesters a variety of polyvalent cations. It is used in pharmaceutical manufacturing and as a food additive. [PubChem]
Structure
Thumb
Synonyms
(ethylenedinitrilo)tetraacetic acid, ion(4−)
{[-(bis-carboxymethyl-amino)-ethyl]-carboxymethyl-amino}-acetic acid
2,2',2'',2'''-(ethane-1,2-diyldinitrilo)tetraacetate
acide edetique
Acide ethylenediaminetetracetique
Acido edetico
Acidum edeticum
EDTA
EDTA, ion(4-)
Ethylenediaminetetraacetate
Ethylenediaminetetraacetic acid
N,N'-1,2-Ethane diylbis-(N-(carboxymethyl)glycine)
External Identifiers Not Available
Approved Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Calcium Disodium VersenateInjection200 mg/mLIntramuscular; IntravenousMedicis Pharmaceutical Corp2013-06-21Not applicableUs
Calcium Disodium VersenateInjection200 mg/mLIntramuscular3 M Pharmaceuticals2009-07-092015-12-31Us
Calcium Disodium VersenateInjection200 mg/mLIntramuscularGraceway Pharmaceuticals, LLC2009-07-092015-12-31Us
Calcium Disodium Versenate Liq 200mg/mlLiquid200 mgIntramuscular; Intravenous; Subcutaneous3 M Pharmaceuticals, A Division Of 3 M Canada Company1993-12-312006-07-24Canada
Approved Generic Prescription ProductsNot Available
Approved Over the Counter ProductsNot Available
Unapproved/Other Products Not Available
International Brands
NameCompany
CheladratePharmex
Diso-TateO'Neal, Jones
EndrateBersworth
Uni WashUnited
Brand mixtures
NameLabellerIngredients
Foam Care Pcmx Surgical Hand ScrubBallard Medical Products
Largal UltraSeptodont
Murine Supplemental TearsAbbott Laboratories, Limited
Salts
Name/CASStructureProperties
Disodium edetate dihydrate
6381-92-6
Thumb
  • InChI Key: OVBJJZOQPCKUOR-UHFFFAOYSA-L
  • Monoisotopic Mass: 372.075684156
  • Average Mass: 372.2369
DBSALT001820
Edetate calcium disodium
62-33-9
Thumb
  • InChI Key: SHWNNYZBHZIQQV-UHFFFAOYSA-J
  • Monoisotopic Mass: 374.001495875
  • Average Mass: 374.268
DBSALT000837
Edetate copper disodium
14025-15-1
Thumb
  • InChI Key: KCFCAUKZKOSSBI-UHFFFAOYSA-J
  • Monoisotopic Mass: 396.968502
  • Average Mass: 397.738
DBSALT001713
Edetate disodium
139-33-3
Thumb
  • InChI Key: ZGTMUACCHSMWAC-UHFFFAOYSA-L
  • Monoisotopic Mass: 336.054554784
  • Average Mass: 336.2063
DBSALT000838
Categories
UNII9G34HU7RV0
CAS number60-00-4
WeightAverage: 292.2426
Monoisotopic: 292.090665498
Chemical FormulaC10H16N2O8
InChI KeyKCXVZYZYPLLWCC-UHFFFAOYSA-N
InChI
InChI=1S/C10H16N2O8/c13-7(14)3-11(4-8(15)16)1-2-12(5-9(17)18)6-10(19)20/h1-6H2,(H,13,14)(H,15,16)(H,17,18)(H,19,20)
IUPAC Name
2-({2-[bis(carboxymethyl)amino]ethyl}(carboxymethyl)amino)acetic acid
SMILES
OC(=O)CN(CCN(CC(O)=O)CC(O)=O)CC(O)=O
Pharmacology
IndicationFor the reduction of blood levels and depot stores of lead in lead poisoning (acute and chronic) and lead encephalopathy, in both pediatric populations and adults.
Structured Indications
PharmacodynamicsEdetate calcium is a heavy metal chelating agent. The calcium in edetate calcium can be displaced by divalent or trivalent metals to form a stable water soluble complex that can be excreted in the urine. In theory, 1 g of edetate calcium can theoretically bind 620 mg of lead, but in reality only about 5 mg per gram is actually excreted into the urine in lead poisoned patients. In addition to chelating lead, edetate calcium also chelates and eliminates zinc from the body. Edetate calcium also binds cadmium, copper, iron and manganese, but to a much lesser extent than either lead or zinc. Edetate calcium is relatively ineffective for use in treating mercury, gold or arsenic poisoning.
Mechanism of actionThe pharmacologic effects of edetate calcium disodium are due to the formation of chelates with divalent and trivalent metals. A stable chelate will form with any metal that has the ability to displace calcium from the molecule, a feature shared by lead, zinc, cadmium, manganese, iron and mercury. The amounts of manganese and iron metabolized are not significant. Copper is not mobilized and mercury is unavailable for chelation because it is too tightly bound to body ligands or it is stored in inaccessible body compartments. The excretion of calcium by the body is not increased following intravenous administration of edetate calcium disodium, but the excretion of zinc is considerably increased.
TargetKindPharmacological actionActionsOrganismUniProt ID
LeadSmall moleculeyes
chelator
Humannot applicabledetails
IronSmall moleculeunknown
chelator
Humannot applicabledetails
Manganese cationSmall moleculeunknown
chelator
Humannot applicabledetails
Related Articles
AbsorptionPoorly absorbed from the gastrointestinal tract. Well absorbed following intramuscular injection.
Volume of distributionNot Available
Protein bindingNot Available
Metabolism

Almost none of the compound is metabolized.

Route of eliminationIt is excreted primarily by the kidney, with about 50% excreted in one hour and over 95% within 24 hours.2 Almost none of the compound is metabolized.
Half lifeThe half life of edetate calcium disodium is 20 to 60 minutes.
ClearanceNot Available
ToxicityInadvertent administration of 5 times the recommended dose, infused intravenously over a 24 hour period, to an asymptomatic 16 month old patient with a blood lead content of 56 mcg/dl did not cause any ill effects. Edetate calcium disodium can aggravate the symptoms of severe lead poisoning, therefore, most toxic effects (cerebral edema, renal tubular necrosis) appear to be associated with lead poisoning. Because of cerebral edema, a therapeutic dose may be lethal to an adult or a pediatric patient with lead encephalopathy. Higher dosage of edetate calcium disodium may produce a more severe zinc deficiency.
Affected organisms
  • Humans and other mammals
PathwaysNot Available
SNP Mediated EffectsNot Available
SNP Mediated Adverse Drug ReactionsNot Available
Interactions
Drug Interactions
DrugInteractionDrug group
AbciximabAbciximab may increase the anticoagulant activities of Edetic Acid.Approved
AceclofenacAceclofenac may increase the anticoagulant activities of Edetic Acid.Approved
AcenocoumarolEdetic Acid may increase the anticoagulant activities of Acenocoumarol.Approved
AcetovanilloneAcetovanillone may increase the anticoagulant activities of Edetic Acid.Investigational
Acetylsalicylic acidAcetylsalicylic acid may increase the anticoagulant activities of Edetic Acid.Approved, Vet Approved
AdapaleneAdapalene may increase the anticoagulant activities of Edetic Acid.Approved
AllylestrenolThe therapeutic efficacy of Edetic Acid can be decreased when used in combination with Allylestrenol.Approved
AlprostadilAlprostadil may increase the anticoagulant activities of Edetic Acid.Approved, Investigational
AlteplaseAlteplase may increase the anticoagulant activities of Edetic Acid.Approved
AltrenogestThe therapeutic efficacy of Edetic Acid can be decreased when used in combination with Altrenogest.Vet Approved
ALX-0081ALX-0081 may increase the anticoagulant activities of Edetic Acid.Investigational
Aminosalicylic AcidAminosalicylic Acid may increase the anticoagulant activities of Edetic Acid.Approved
AnagrelideAnagrelide may increase the anticoagulant activities of Edetic Acid.Approved
AncrodEdetic Acid may increase the anticoagulant activities of Ancrod.Investigational
AnisodamineAnisodamine may increase the anticoagulant activities of Edetic Acid.Investigational
AnistreplaseAnistreplase may increase the anticoagulant activities of Edetic Acid.Approved
AntipyrineAntipyrine may increase the anticoagulant activities of Edetic Acid.Approved
Antithrombin III humanEdetic Acid may increase the anticoagulant activities of Antithrombin III human.Approved
ApixabanApixaban may increase the anticoagulant activities of Edetic Acid.Approved
ApremilastApremilast may increase the anticoagulant activities of Edetic Acid.Approved, Investigational
ArdeparinArdeparin may increase the anticoagulant activities of Edetic Acid.Approved, Withdrawn
ArgatrobanArgatroban may increase the anticoagulant activities of Edetic Acid.Approved, Investigational
AstaxanthinAstaxanthin may increase the anticoagulant activities of Edetic Acid.Investigational
AzapropazoneAzapropazone may increase the anticoagulant activities of Edetic Acid.Withdrawn
AzelastineAzelastine may increase the anticoagulant activities of Edetic Acid.Approved
BalsalazideBalsalazide may increase the anticoagulant activities of Edetic Acid.Approved, Investigational
BatroxobinBatroxobin may increase the anticoagulant activities of Edetic Acid.Experimental
BazedoxifeneBazedoxifene may decrease the anticoagulant activities of Edetic Acid.Approved, Investigational
BecaplerminBecaplermin may increase the anticoagulant activities of Edetic Acid.Approved, Investigational
BemiparinBemiparin may increase the anticoagulant activities of Edetic Acid.Approved
BenoxaprofenBenoxaprofen may increase the anticoagulant activities of Edetic Acid.Withdrawn
BeraprostBeraprost may increase the anticoagulant activities of Edetic Acid.Investigational
Betulinic AcidBetulinic Acid may increase the anticoagulant activities of Edetic Acid.Investigational
BivalirudinBivalirudin may increase the anticoagulant activities of Edetic Acid.Approved, Investigational
BromfenacBromfenac may increase the anticoagulant activities of Edetic Acid.Approved
BucillamineBucillamine may increase the anticoagulant activities of Edetic Acid.Investigational
ButylphthalideButylphthalide may increase the anticoagulant activities of Edetic Acid.Investigational
CangrelorCangrelor may increase the anticoagulant activities of Edetic Acid.Approved
CarprofenCarprofen may increase the anticoagulant activities of Edetic Acid.Approved, Vet Approved, Withdrawn
CastanospermineCastanospermine may increase the anticoagulant activities of Edetic Acid.Experimental
CelecoxibCelecoxib may increase the anticoagulant activities of Edetic Acid.Approved, Investigational
CertoparinEdetic Acid may increase the anticoagulant activities of Certoparin.Approved
ChloroquineChloroquine may increase the anticoagulant activities of Edetic Acid.Approved, Vet Approved
ChlorotrianiseneChlorotrianisene may decrease the anticoagulant activities of Edetic Acid.Withdrawn
CilostazolCilostazol may increase the anticoagulant activities of Edetic Acid.Approved
Citric AcidEdetic Acid may increase the anticoagulant activities of Citric Acid.Nutraceutical, Vet Approved
ClonixinClonixin may increase the anticoagulant activities of Edetic Acid.Approved
ClopidogrelClopidogrel may increase the anticoagulant activities of Edetic Acid.Approved, Nutraceutical
CollagenaseThe risk or severity of adverse effects can be increased when Edetic Acid is combined with Collagenase.Approved
Conjugated Equine EstrogensConjugated Equine Estrogens may decrease the anticoagulant activities of Edetic Acid.Approved
CurcuminCurcumin may increase the anticoagulant activities of Edetic Acid.Investigational
D-LimoneneD-Limonene may increase the anticoagulant activities of Edetic Acid.Investigational
Dabigatran etexilateDabigatran etexilate may increase the anticoagulant activities of Edetic Acid.Approved
DalteparinEdetic Acid may increase the anticoagulant activities of Dalteparin.Approved
DanaparoidEdetic Acid may increase the anticoagulant activities of Danaparoid.Approved, Withdrawn
DasatinibDasatinib may increase the anticoagulant activities of Edetic Acid.Approved, Investigational
DeferasiroxThe risk or severity of adverse effects can be increased when Edetic Acid is combined with Deferasirox.Approved, Investigational
DefibrotideDefibrotide may increase the anticoagulant activities of Edetic Acid.Approved, Investigational
Deoxycholic AcidThe risk or severity of adverse effects can be increased when Edetic Acid is combined with Deoxycholic Acid.Approved
dersalazinedersalazine may increase the anticoagulant activities of Edetic Acid.Investigational
DesirudinEdetic Acid may increase the anticoagulant activities of Desirudin.Approved
DesmoteplaseDesmoteplase may increase the anticoagulant activities of Edetic Acid.Investigational
DesogestrelThe therapeutic efficacy of Edetic Acid can be decreased when used in combination with Desogestrel.Approved
DextranEdetic Acid may increase the anticoagulant activities of Dextran.Approved, Vet Approved
Dextran 40Edetic Acid may increase the anticoagulant activities of Dextran 40.Approved
Dextran 70Edetic Acid may increase the anticoagulant activities of Dextran 70.Approved
Dextran 75Edetic Acid may increase the anticoagulant activities of Dextran 75.Approved
DiclofenacDiclofenac may increase the anticoagulant activities of Edetic Acid.Approved, Vet Approved
DicoumarolDicoumarol may increase the anticoagulant activities of Edetic Acid.Approved
DienestrolDienestrol may decrease the anticoagulant activities of Edetic Acid.Approved
DienogestThe therapeutic efficacy of Edetic Acid can be decreased when used in combination with Dienogest.Approved
DiethylstilbestrolDiethylstilbestrol may decrease the anticoagulant activities of Edetic Acid.Approved
DiflunisalDiflunisal may increase the anticoagulant activities of Edetic Acid.Approved
DipyridamoleDipyridamole may increase the anticoagulant activities of Edetic Acid.Approved
DitazoleDitazole may increase the anticoagulant activities of Edetic Acid.Approved, Withdrawn
DrospirenoneThe therapeutic efficacy of Edetic Acid can be decreased when used in combination with Drospirenone.Approved
Drotrecogin alfaDrotrecogin alfa may increase the anticoagulant activities of Edetic Acid.Approved, Investigational, Withdrawn
DroxicamDroxicam may increase the anticoagulant activities of Edetic Acid.Approved
DuvelisibDuvelisib may increase the anticoagulant activities of Edetic Acid.Investigational
DydrogesteroneThe therapeutic efficacy of Edetic Acid can be decreased when used in combination with Dydrogesterone.Approved, Withdrawn
E6201E6201 may increase the anticoagulant activities of Edetic Acid.Investigational
EbselenEbselen may increase the anticoagulant activities of Edetic Acid.Investigational
EdoxabanEdoxaban may increase the anticoagulant activities of Edetic Acid.Approved
EnoxaparinEdetic Acid may increase the anticoagulant activities of Enoxaparin.Approved
EpinastineEpinastine may increase the anticoagulant activities of Edetic Acid.Approved, Investigational
EpirizoleEpirizole may increase the anticoagulant activities of Edetic Acid.Approved
eplivanserineeplivanserine may increase the anticoagulant activities of Edetic Acid.Investigational
EpoprostenolEpoprostenol may increase the anticoagulant activities of Edetic Acid.Approved
EptifibatideEptifibatide may increase the anticoagulant activities of Edetic Acid.Approved, Investigational
EstradiolEstradiol may decrease the anticoagulant activities of Edetic Acid.Approved, Investigational, Vet Approved
EstriolEstriol may decrease the anticoagulant activities of Edetic Acid.Approved, Vet Approved
EstroneEstrone may decrease the anticoagulant activities of Edetic Acid.Approved
EtanerceptEtanercept may increase the anticoagulant activities of Edetic Acid.Approved, Investigational
Ethinyl EstradiolEthinyl Estradiol may decrease the anticoagulant activities of Edetic Acid.Approved
Ethyl biscoumacetateEdetic Acid may increase the anticoagulant activities of Ethyl biscoumacetate.Withdrawn
Ethynodiol diacetateThe therapeutic efficacy of Edetic Acid can be decreased when used in combination with Ethynodiol diacetate.Approved
EtodolacEtodolac may increase the anticoagulant activities of Edetic Acid.Approved, Investigational, Vet Approved
EtofenamateEtofenamate may increase the anticoagulant activities of Edetic Acid.Approved
EtonogestrelThe therapeutic efficacy of Edetic Acid can be decreased when used in combination with Etonogestrel.Approved, Investigational
EtoricoxibEtoricoxib may increase the anticoagulant activities of Edetic Acid.Approved, Investigational
Evening primrose oilEvening primrose oil may increase the anticoagulant activities of Edetic Acid.Approved
exisulindexisulind may increase the anticoagulant activities of Edetic Acid.Investigational
FenbufenFenbufen may increase the anticoagulant activities of Edetic Acid.Approved
FenoprofenFenoprofen may increase the anticoagulant activities of Edetic Acid.Approved
FibrinolysinFibrinolysin may increase the anticoagulant activities of Edetic Acid.Approved
FloctafenineFloctafenine may increase the anticoagulant activities of Edetic Acid.Approved, Withdrawn
FluindioneEdetic Acid may increase the anticoagulant activities of Fluindione.Investigational
FlunixinFlunixin may increase the anticoagulant activities of Edetic Acid.Vet Approved
FlurbiprofenFlurbiprofen may increase the anticoagulant activities of Edetic Acid.Approved, Investigational
FondaparinuxEdetic Acid may increase the anticoagulant activities of Fondaparinux.Investigational
Fondaparinux sodiumFondaparinux sodium may increase the anticoagulant activities of Edetic Acid.Approved, Investigational
GabexateEdetic Acid may increase the anticoagulant activities of Gabexate.Investigational
GenisteinGenistein may decrease the anticoagulant activities of Edetic Acid.Investigational
GestodeneThe therapeutic efficacy of Edetic Acid can be decreased when used in combination with Gestodene.Approved
GestrinoneThe therapeutic efficacy of Edetic Acid can be decreased when used in combination with Gestrinone.Approved
HeminHemin may increase the anticoagulant activities of Edetic Acid.Approved
HeparinEdetic Acid may increase the anticoagulant activities of Heparin.Approved, Investigational
HexestrolHexestrol may decrease the anticoagulant activities of Edetic Acid.Withdrawn
HigenamineHigenamine may increase the anticoagulant activities of Edetic Acid.Investigational
HirulogEdetic Acid may increase the anticoagulant activities of Hirulog.Experimental
HMPL-004HMPL-004 may increase the anticoagulant activities of Edetic Acid.Investigational
Hydroxyprogesterone caproateThe therapeutic efficacy of Edetic Acid can be decreased when used in combination with Hydroxyprogesterone caproate.Approved
Ibritumomab tiuxetanThe risk or severity of adverse effects can be increased when Edetic Acid is combined with Ibritumomab tiuxetan.Approved
IbrutinibThe risk or severity of adverse effects can be increased when Ibrutinib is combined with Edetic Acid.Approved
IbudilastIbudilast may increase the anticoagulant activities of Edetic Acid.Approved, Investigational
IbuprofenIbuprofen may increase the anticoagulant activities of Edetic Acid.Approved
IbuproxamIbuproxam may increase the anticoagulant activities of Edetic Acid.Withdrawn
IcatibantIcatibant may increase the anticoagulant activities of Edetic Acid.Approved
Icosapent ethylIcosapent ethyl may increase the anticoagulant activities of Edetic Acid.Approved, Nutraceutical
idraparinuxEdetic Acid may increase the anticoagulant activities of idraparinux.Investigational
IfenprodilIfenprodil may increase the anticoagulant activities of Edetic Acid.Approved, Withdrawn
IloprostIloprost may increase the anticoagulant activities of Edetic Acid.Approved, Investigational
IndobufenIndobufen may increase the anticoagulant activities of Edetic Acid.Investigational
IndomethacinIndomethacin may increase the anticoagulant activities of Edetic Acid.Approved, Investigational
IndoprofenIndoprofen may increase the anticoagulant activities of Edetic Acid.Withdrawn
Insulin PorkEdetic Acid may increase the hypoglycemic activities of Insulin Pork.Approved
IsoxicamIsoxicam may increase the anticoagulant activities of Edetic Acid.Withdrawn
Kct 0809Kct 0809 may increase the anticoagulant activities of Edetic Acid.Investigational
KebuzoneKebuzone may increase the anticoagulant activities of Edetic Acid.Experimental
KetanserinKetanserin may increase the anticoagulant activities of Edetic Acid.Investigational
KetoprofenKetoprofen may increase the anticoagulant activities of Edetic Acid.Approved, Vet Approved
KetorolacKetorolac may increase the anticoagulant activities of Edetic Acid.Approved
LeflunomideLeflunomide may increase the anticoagulant activities of Edetic Acid.Approved, Investigational
LepirudinLepirudin may increase the anticoagulant activities of Edetic Acid.Approved
LevonorgestrelThe therapeutic efficacy of Edetic Acid can be decreased when used in combination with Levonorgestrel.Approved, Investigational
LimaprostThe risk or severity of adverse effects can be increased when Limaprost is combined with Edetic Acid.Approved
LisofyllineLisofylline may increase the anticoagulant activities of Edetic Acid.Investigational
LornoxicamLornoxicam may increase the anticoagulant activities of Edetic Acid.Approved
LoxoprofenLoxoprofen may increase the anticoagulant activities of Edetic Acid.Approved
LumiracoxibLumiracoxib may increase the anticoagulant activities of Edetic Acid.Approved, Investigational
LynestrenolThe therapeutic efficacy of Edetic Acid can be decreased when used in combination with Lynestrenol.Investigational
Magnesium salicylateMagnesium salicylate may increase the anticoagulant activities of Edetic Acid.Approved
MasoprocolMasoprocol may increase the anticoagulant activities of Edetic Acid.Approved
Meclofenamic acidMeclofenamic acid may increase the anticoagulant activities of Edetic Acid.Approved, Vet Approved
MedrogestoneThe therapeutic efficacy of Edetic Acid can be decreased when used in combination with Medrogestone.Approved
Medroxyprogesterone acetateThe therapeutic efficacy of Edetic Acid can be decreased when used in combination with Medroxyprogesterone acetate.Approved, Investigational
Mefenamic acidMefenamic acid may increase the anticoagulant activities of Edetic Acid.Approved
Megestrol acetateThe therapeutic efficacy of Edetic Acid can be decreased when used in combination with Megestrol acetate.Approved, Vet Approved
MeloxicamMeloxicam may increase the anticoagulant activities of Edetic Acid.Approved, Vet Approved
MesalazineMesalazine may increase the anticoagulant activities of Edetic Acid.Approved
MestranolMestranol may decrease the anticoagulant activities of Edetic Acid.Approved
MetamizoleMetamizole may increase the anticoagulant activities of Edetic Acid.Withdrawn
MethallenestrilMethallenestril may decrease the anticoagulant activities of Edetic Acid.Experimental
MilrinoneMilrinone may increase the anticoagulant activities of Edetic Acid.Approved
MizoribineMizoribine may increase the anticoagulant activities of Edetic Acid.Investigational
Mycophenolate mofetilMycophenolate mofetil may increase the anticoagulant activities of Edetic Acid.Approved, Investigational
Mycophenolic acidMycophenolic acid may increase the anticoagulant activities of Edetic Acid.Approved
NabumetoneNabumetone may increase the anticoagulant activities of Edetic Acid.Approved
NadroparinEdetic Acid may increase the anticoagulant activities of Nadroparin.Approved
NafamostatNafamostat may increase the anticoagulant activities of Edetic Acid.Investigational
NaftifineNaftifine may increase the anticoagulant activities of Edetic Acid.Approved
NaftopidilNaftopidil may increase the anticoagulant activities of Edetic Acid.Investigational
NaproxenNaproxen may increase the anticoagulant activities of Edetic Acid.Approved, Vet Approved
NCX 4016NCX 4016 may increase the anticoagulant activities of Edetic Acid.Investigational
NepafenacNepafenac may increase the anticoagulant activities of Edetic Acid.Approved
Niflumic AcidNiflumic Acid may increase the anticoagulant activities of Edetic Acid.Approved
NimesulideNimesulide may increase the anticoagulant activities of Edetic Acid.Approved, Withdrawn
NintedanibThe risk or severity of adverse effects can be increased when Edetic Acid is combined with Nintedanib.Approved
NitroaspirinNitroaspirin may increase the anticoagulant activities of Edetic Acid.Investigational
NomegestrolThe therapeutic efficacy of Edetic Acid can be decreased when used in combination with Nomegestrol.Approved
NorethisteroneThe therapeutic efficacy of Edetic Acid can be decreased when used in combination with Norethisterone.Approved
ObinutuzumabThe risk or severity of adverse effects can be increased when Edetic Acid is combined with Obinutuzumab.Approved
OlopatadineOlopatadine may increase the anticoagulant activities of Edetic Acid.Approved
OlsalazineOlsalazine may increase the anticoagulant activities of Edetic Acid.Approved
Omacetaxine mepesuccinateThe risk or severity of adverse effects can be increased when Edetic Acid is combined with Omacetaxine mepesuccinate.Approved
Omega-3 fatty acidsOmega-3 fatty acids may increase the anticoagulant activities of Edetic Acid.Approved
OrgoteinOrgotein may increase the anticoagulant activities of Edetic Acid.Vet Approved
OtamixabanEdetic Acid may increase the anticoagulant activities of Otamixaban.Investigational
OxaprozinOxaprozin may increase the anticoagulant activities of Edetic Acid.Approved
OxyphenbutazoneOxyphenbutazone may increase the anticoagulant activities of Edetic Acid.Withdrawn
ParecoxibParecoxib may increase the anticoagulant activities of Edetic Acid.Approved
ParnaparinParnaparin may increase the anticoagulant activities of Edetic Acid.Approved
Pentosan PolysulfatePentosan Polysulfate may increase the anticoagulant activities of Edetic Acid.Approved
PentoxifyllinePentoxifylline may increase the anticoagulant activities of Edetic Acid.Approved, Investigational
PhenindionePhenindione may increase the anticoagulant activities of Edetic Acid.Approved
PhenprocoumonPhenprocoumon may increase the anticoagulant activities of Edetic Acid.Approved
PhenylbutazonePhenylbutazone may increase the anticoagulant activities of Edetic Acid.Approved, Vet Approved
PimecrolimusPimecrolimus may increase the anticoagulant activities of Edetic Acid.Approved, Investigational
PirfenidonePirfenidone may increase the anticoagulant activities of Edetic Acid.Investigational
PiroxicamPiroxicam may increase the anticoagulant activities of Edetic Acid.Approved, Investigational
PlasminPlasmin may increase the anticoagulant activities of Edetic Acid.Investigational
Polyestradiol phosphatePolyestradiol phosphate may decrease the anticoagulant activities of Edetic Acid.Approved
PrasugrelPrasugrel may increase the anticoagulant activities of Edetic Acid.Approved
ProgesteroneThe therapeutic efficacy of Edetic Acid can be decreased when used in combination with Progesterone.Approved, Vet Approved
PromestrienePromestriene may decrease the anticoagulant activities of Edetic Acid.Investigational
PropacetamolPropacetamol may increase the anticoagulant activities of Edetic Acid.Approved
Protein CEdetic Acid may increase the anticoagulant activities of Protein C.Approved
Protein S humanEdetic Acid may increase the anticoagulant activities of Protein S human.Approved
ProtocatechualdehydeEdetic Acid may increase the anticoagulant activities of Protocatechualdehyde.Approved
PTC299PTC299 may increase the anticoagulant activities of Edetic Acid.Investigational
QuinestrolQuinestrol may decrease the anticoagulant activities of Edetic Acid.Approved
RamatrobanRamatroban may increase the anticoagulant activities of Edetic Acid.Investigational
ResveratrolResveratrol may increase the anticoagulant activities of Edetic Acid.Experimental, Investigational
ReteplaseReteplase may increase the anticoagulant activities of Edetic Acid.Approved
ReviparinEdetic Acid may increase the anticoagulant activities of Reviparin.Approved
RidogrelRidogrel may increase the anticoagulant activities of Edetic Acid.Approved
RivaroxabanEdetic Acid may increase the anticoagulant activities of Rivaroxaban.Approved
RofecoxibRofecoxib may increase the anticoagulant activities of Edetic Acid.Investigational, Withdrawn
RosiglitazoneRosiglitazone may increase the anticoagulant activities of Edetic Acid.Approved, Investigational
S EquolS Equol may decrease the anticoagulant activities of Edetic Acid.Investigational
SalicylamideSalicylamide may increase the anticoagulant activities of Edetic Acid.Approved
Salicylic acidSalicylic acid may increase the anticoagulant activities of Edetic Acid.Approved, Vet Approved
SalsalateSalsalate may increase the anticoagulant activities of Edetic Acid.Approved
SCH-530348SCH-530348 may increase the anticoagulant activities of Edetic Acid.Investigational
SecoisolariciresinolSecoisolariciresinol may decrease the anticoagulant activities of Edetic Acid.Investigational
SelexipagSelexipag may increase the anticoagulant activities of Edetic Acid.Approved
SeratrodastSeratrodast may increase the anticoagulant activities of Edetic Acid.Approved, Investigational
SevofluraneSevoflurane may increase the anticoagulant activities of Edetic Acid.Approved, Vet Approved
SRT501SRT501 may increase the anticoagulant activities of Edetic Acid.Investigational
StreptokinaseStreptokinase may increase the anticoagulant activities of Edetic Acid.Approved
SugammadexSugammadex may increase the anticoagulant activities of Edetic Acid.Approved
SulfasalazineSulfasalazine may increase the anticoagulant activities of Edetic Acid.Approved
SulindacSulindac may increase the anticoagulant activities of Edetic Acid.Approved
SulodexideEdetic Acid may increase the anticoagulant activities of Sulodexide.Approved, Investigational
SuprofenSuprofen may increase the anticoagulant activities of Edetic Acid.Approved, Withdrawn
Synthetic Conjugated Estrogens, ASynthetic Conjugated Estrogens, A may decrease the anticoagulant activities of Edetic Acid.Approved
Synthetic Conjugated Estrogens, BSynthetic Conjugated Estrogens, B may decrease the anticoagulant activities of Edetic Acid.Approved
TenecteplaseTenecteplase may increase the anticoagulant activities of Edetic Acid.Approved
TenoxicamTenoxicam may increase the anticoagulant activities of Edetic Acid.Approved
TepoxalinTepoxalin may increase the anticoagulant activities of Edetic Acid.Vet Approved
TeriflunomideTeriflunomide may increase the anticoagulant activities of Edetic Acid.Approved
TesmilifeneTesmilifene may increase the anticoagulant activities of Edetic Acid.Investigational
Tiaprofenic acidTiaprofenic acid may increase the anticoagulant activities of Edetic Acid.Approved
TiboloneTibolone may increase the anticoagulant activities of Edetic Acid.Approved
TicagrelorTicagrelor may increase the anticoagulant activities of Edetic Acid.Approved
TiclopidineTiclopidine may increase the anticoagulant activities of Edetic Acid.Approved
TinoridineTinoridine may increase the anticoagulant activities of Edetic Acid.Investigational
TinzaparinTinzaparin may increase the anticoagulant activities of Edetic Acid.Approved
TipranavirTipranavir may increase the anticoagulant activities of Edetic Acid.Approved, Investigational
TirofibanTirofiban may increase the anticoagulant activities of Edetic Acid.Approved
Tolfenamic AcidTolfenamic Acid may increase the anticoagulant activities of Edetic Acid.Approved
TolmetinTolmetin may increase the anticoagulant activities of Edetic Acid.Approved
TositumomabThe risk or severity of adverse effects can be increased when Edetic Acid is combined with Tositumomab.Approved
TranilastTranilast may increase the anticoagulant activities of Edetic Acid.Approved, Investigational
TrapidilTrapidil may increase the anticoagulant activities of Edetic Acid.Approved
TreprostinilTreprostinil may increase the anticoagulant activities of Edetic Acid.Approved, Investigational
TriflusalTriflusal may increase the anticoagulant activities of Edetic Acid.Approved
Trisalicylate-cholineTrisalicylate-choline may increase the anticoagulant activities of Edetic Acid.Approved
UrokinaseUrokinase may increase the anticoagulant activities of Edetic Acid.Approved, Investigational, Withdrawn
ValdecoxibValdecoxib may increase the anticoagulant activities of Edetic Acid.Investigational, Withdrawn
Vitamin EVitamin E may increase the anticoagulant activities of Edetic Acid.Approved, Nutraceutical, Vet Approved
VorapaxarThe risk or severity of adverse effects can be increased when Vorapaxar is combined with Edetic Acid.Approved
WarfarinWarfarin may increase the anticoagulant activities of Edetic Acid.Approved
XimelagatranEdetic Acid may increase the anticoagulant activities of Ximelagatran.Approved, Investigational, Withdrawn
Ym150Edetic Acid may increase the anticoagulant activities of Ym150.Investigational
ZaltoprofenZaltoprofen may increase the anticoagulant activities of Edetic Acid.Approved
ZeranolZeranol may decrease the anticoagulant activities of Edetic Acid.Vet Approved
ZileutonZileuton may increase the anticoagulant activities of Edetic Acid.Approved, Investigational, Withdrawn
ZomepiracZomepirac may increase the anticoagulant activities of Edetic Acid.Withdrawn
Food InteractionsNot Available
References
Synthesis Reference

Bersworth, F.C.; U.S. Patent 2,407,645; September 17,1946; assigned to The Martin Dennis Co.

General ReferencesNot Available
External Links
ATC CodesNot Available
AHFS CodesNot Available
PDB Entries
FDA labelNot Available
MSDSNot Available
ADMET
Predicted ADMET features
PropertyValueProbability
Human Intestinal Absorption-0.8668
Blood Brain Barrier-0.7126
Caco-2 permeable-0.5739
P-glycoprotein substrateSubstrate0.6377
P-glycoprotein inhibitor INon-inhibitor0.9296
P-glycoprotein inhibitor IINon-inhibitor0.972
Renal organic cation transporterNon-inhibitor0.8473
CYP450 2C9 substrateNon-substrate0.8457
CYP450 2D6 substrateNon-substrate0.8271
CYP450 3A4 substrateNon-substrate0.7616
CYP450 1A2 substrateNon-inhibitor0.8959
CYP450 2C9 inhibitorNon-inhibitor0.9225
CYP450 2D6 inhibitorNon-inhibitor0.9306
CYP450 2C19 inhibitorNon-inhibitor0.9174
CYP450 3A4 inhibitorNon-inhibitor0.9288
CYP450 inhibitory promiscuityLow CYP Inhibitory Promiscuity0.9891
Ames testNon AMES toxic0.9132
CarcinogenicityNon-carcinogens0.7715
BiodegradationNot ready biodegradable0.8307
Rat acute toxicity1.8974 LD50, mol/kg Not applicable
hERG inhibition (predictor I)Weak inhibitor0.8158
hERG inhibition (predictor II)Non-inhibitor0.9341
ADMET data is predicted using admetSAR, a free tool for evaluating chemical ADMET properties. (23092397 )
Pharmacoeconomics
Manufacturers
  • Graceway pharmaceuticals llc
  • Watson laboratories inc
  • 3m pharmaceuticals inc
Packagers
Dosage forms
FormRouteStrength
InjectionIntramuscular200 mg/mL
InjectionIntramuscular; Intravenous200 mg/mL
LiquidIntramuscular; Intravenous; Subcutaneous200 mg
LiquidTopical
LiquidDental
LiquidOphthalmic
Prices
Unit descriptionCostUnit
Endrate 150 mg/ml ampul1.44USD ml
DrugBank does not sell nor buy drugs. Pricing information is supplied for informational purposes only.
PatentsNot Available
Properties
StateSolid
Experimental Properties
PropertyValueSource
melting point237 °CNot Available
water solubility1000000 mg/L at 25 °CMEYLAN,WM et al. (1996)
logP-2.6Not Available
Predicted Properties
PropertyValueSource
Water Solubility9.26 mg/mLALOGPS
logP-1.2ALOGPS
logP-5.2ChemAxon
logS-1.5ALOGPS
pKa (Strongest Acidic)1.49ChemAxon
pKa (Strongest Basic)8.13ChemAxon
Physiological Charge-3ChemAxon
Hydrogen Acceptor Count10ChemAxon
Hydrogen Donor Count4ChemAxon
Polar Surface Area155.68 Å2ChemAxon
Rotatable Bond Count11ChemAxon
Refractivity62.35 m3·mol-1ChemAxon
Polarizability25.64 Å3ChemAxon
Number of Rings0ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleYesChemAxon
Spectra
Mass Spec (NIST)Download (10.2 KB)
Spectra
Spectrum TypeDescriptionSplash Key
GC-MSGC-MS Spectrum - GC-MS (4 TMS)splash10-0f6x-2971000000-52370879752b5b63ccc2View in MoNA
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, PositiveNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, PositiveNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, PositiveNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, NegativeNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, NegativeNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, NegativeNot Available
Taxonomy
DescriptionThis compound belongs to the class of organic compounds known as tetracarboxylic acids and derivatives. These are carboxylic acids containing exactly four carboxyl groups.
KingdomOrganic compounds
Super ClassOrganic acids and derivatives
ClassCarboxylic acids and derivatives
Sub ClassTetracarboxylic acids and derivatives
Direct ParentTetracarboxylic acids and derivatives
Alternative Parents
Substituents
  • Tetracarboxylic acid or derivatives
  • Alpha-amino acid or derivatives
  • Alpha-amino acid
  • Tertiary aliphatic amine
  • Tertiary amine
  • Carboxylic acid
  • Hydrocarbon derivative
  • Organooxygen compound
  • Organonitrogen compound
  • Carbonyl group
  • Amine
  • Aliphatic acyclic compound
Molecular FrameworkAliphatic acyclic compounds
External Descriptors

Targets

1. Lead
Kind
Small molecule
Organism
Human
Pharmacological action
yes
Actions
chelator
References
  1. Onnby L, Giorgi C, Plieva FM, Mattiasson B: Removal of heavy metals from water effluents using supermacroporous metal chelating cryogels. Biotechnol Prog. 2010 Sep-Oct;26(5):1295-302. doi: 10.1002/btpr.422. [PubMed:20945486 ]
  2. Chakraborty N, Banerjee A, Pal R: Accumulation of lead by free and immobilized cyanobacteria with special reference to accumulation factor and recovery. Bioresour Technol. 2011 Mar;102(5):4191-5. doi: 10.1016/j.biortech.2010.12.028. Epub 2010 Dec 13. [PubMed:21195608 ]
  3. Tian SK, Lu LL, Yang XE, Huang HG, Brown P, Labavitch J, Liao HB, He ZL: The impact of EDTA on lead distribution and speciation in the accumulator Sedum alfredii by synchrotron X-ray investigation. Environ Pollut. 2011 Mar;159(3):782-8. doi: 10.1016/j.envpol.2010.11.020. Epub 2010 Dec 18. [PubMed:21168940 ]
2. Iron
Kind
Small molecule
Organism
Human
Pharmacological action
unknown
Actions
chelator
References
  1. Hasegawa H, Rahman IM, Kinoshita S, Maki T, Furusho Y: Separation of dissolved iron from the aqueous system with excess ligand. Chemosphere. 2011 Feb;82(8):1161-7. doi: 10.1016/j.chemosphere.2010.12.048. Epub 2011 Jan 3. [PubMed:21208637 ]
3. Manganese cation
Kind
Small molecule
Organism
Human
Pharmacological action
unknown
Actions
chelator
References
  1. Broncel M, Wagner SC, Paul K, Hackenberger CP, Koksch B: Towards understanding secondary structure transitions: phosphorylation and metal coordination in model peptides. Org Biomol Chem. 2010 Jun 7;8(11):2575-9. doi: 10.1039/c001458c. Epub 2010 Mar 29. [PubMed:20485793 ]

Enzymes

Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Zinc ion binding
Specific Function:
Catalyzes the hydrolytic deamination of adenosine and 2-deoxyadenosine. Plays an important role in purine metabolism and in adenosine homeostasis. Modulates signaling by extracellular adenosine, and so contributes indirectly to cellular signaling events. Acts as a positive regulator of T-cell coactivation, by binding DPP4. Its interaction with DPP4 regulates lymphocyte-epithelial cell adhesion.
Gene Name:
ADA
Uniprot ID:
P00813
Molecular Weight:
40764.13 Da
References
  1. Abu-Shady MR, Elshafei AM, el-Beih FM, Mohamed LA: Properties of adenosine deaminase in extracts of Asperigillus terricola. Acta Microbiol Pol. 1994;43(3-4):305-11. [PubMed:7740980 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. Most active in catalyzing 2-hydroxylation. Caffeine is metabolized primarily by cytochrome CYP1A2 in the liver through an initial N...
Gene Name:
CYP1A2
Uniprot ID:
P05177
Molecular Weight:
58293.76 Da
References
  1. Bournique B, Petry M, Gousset G: Usefulness of statistic experimental designs in enzymology: example with recombinant hCYP3A4 and 1A2. Anal Biochem. 1999 Dec 1;276(1):18-26. [PubMed:10585740 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Protein homodimerization activity
Specific Function:
Has low activity towards the organophosphate paraxon and aromatic carboxylic acid esters. Rapidly hydrolyzes lactones such as statin prodrugs (e.g. lovastatin). Hydrolyzes aromatic lactones and 5- or 6-member ring lactones with aliphatic substituents but not simple lactones or those with polar substituents.
Gene Name:
PON3
Uniprot ID:
Q15166
Molecular Weight:
39607.185 Da
References
  1. Pla A, Rodrigo L, Hernandez AF, Gil F, Lopez O: Effect of metal ions and calcium on purified PON1 and PON3 from rat liver. Chem Biol Interact. 2007 Apr 5;167(1):63-70. Epub 2007 Jan 16. [PubMed:17292339 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrate
General Function:
Oxygen binding
Specific Function:
Catalyzes the formation of aromatic C18 estrogens from C19 androgens.
Gene Name:
CYP19A1
Uniprot ID:
P11511
Molecular Weight:
57882.48 Da
References
  1. Moslemi S, Vibet A, Papadopoulos V, Camoin L, Silberzahn P, Gaillard JL: Purification and characterization of equine testicular cytochrome P-450 aromatase: comparison with the human enzyme. Comp Biochem Physiol B Biochem Mol Biol. 1997 Sep;118(1):217-27. [PubMed:9418012 ]
  2. Bellino FL, Holben L: Placental estrogen synthetase (aromatase): evidence for phosphatase-dependent inactivation. Biochem Biophys Res Commun. 1989 Jul 14;162(1):498-504. [PubMed:2546553 ]
  3. Zhang F, Zhou D, Kao YC, Ye J, Chen S: Expression and purification of a recombinant form of human aromatase from Escherichia coli. Biochem Pharmacol. 2002 Nov 1;64(9):1317-24. [PubMed:12392814 ]
  4. Milczarek R, Sokolowska E, Hallmann A, Kaletha K, Klimek J: NADPH- and iron-dependent lipid peroxidation inhibit aromatase activity in human placental microsomes. J Steroid Biochem Mol Biol. 2008 Jun;110(3-5):230-5. doi: 10.1016/j.jsbmb.2007.11.004. Epub 2008 Apr 20. [PubMed:18499441 ]
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Drug created on June 13, 2005 07:24 / Updated on August 17, 2016 12:23