Displaying drugs 3601 - 3625 of 11853 in total
Ropeginterferon alfa-2b
Polycythemia vera (PV) is the most common Philadelphia chromosome-negative myeloproliferative neoplasm (MPN), characterized by increased hematocrit and platelet/leukocyte counts, an increased risk for hemorrhage and thromboembolic events, and a long-term propensity for myelofibrosis and leukemia.[A242000, A242005] Interferon alfa-2b has been used for decades to treat PV but requires frequent dosing...
Approved
Investigational
Matched Description: … proline-IFN-α-2b in _Escherichia coli_ that has high tolerability and a long half-life. ... [A242005] Ropeginterferon alfa-2b is a next-generation mono-pegylated type I interferon produced from ... hematocrit and platelet/leukocyte counts, an increased risk for hemorrhage and thromboembolic events, and a …
Anthrax immune globulin human
Anthrax immune globulin is a human antibody given with antibiotics for the treatment of anthrax. It is derived from the plasma of humans immunized with BioThrax (adsorbed anthrax vaccine), which is then further purified. Available as the product Anthrasil (FDA), the result is a solution for slow IV infusion containing...
Approved
Matched Description: … Anthrax immune globulin is a human antibody given with antibiotics for the treatment of anthrax. ... Available as the product Anthrasil (FDA), the result is a solution for slow IV infusion containing polyclonal …
Hydromorphone
Hydromorphone is a pure opioid, a semi-synthetic hydrogenated ketone derivative of morphine that has been available clinically since 1920. Structurally, hydromorphone derived from morphine in the modification of the hydroxyl group in the carbon 6 to a carbonyl and the absence of a double bond between the carbon 7 and...
Approved
Illicit
Matched Description: … Hydromorphone is a pure opioid,[A176468] a semi-synthetic hydrogenated ketone derivative of [morphine ... carbonyl and the absence of a double bond between the carbon 7 and 8. ... hydromorphone derived from [morphine] in the modification of the hydroxyl group in the carbon 6 to a …
Salix lasiolepis pollen
Salix lasiolepis pollen is the pollen of the Salix lasiolepis plant. Salix lasiolepis pollen is mainly used in allergenic testing.
Approved
Protamine sulfate
Since it's earliest discovery in salmon rine sperm heads in the late 1800's to its formal introduction via US FDA approval in 1939, protamine sulfate has occupied an important therapeutic niche as perhaps the only viable option for reversing the anticoagulant effect of heparin use for over 77 years [A174778,...
Approved
Matched Description: … relative importance of protamine sulfate's medical indication, the medication can notoriously cause a ... As a consequence, whenever protamine sulfate use is clinically considered, careful consideration must ... to whether the use of the agent could decrease the safety of the procedure or worsen the recovery of a …
Juniperus ashei pollen
Juniperus ashei pollen is the pollen of the Juniperus ashei plant. Juniperus ashei pollen is mainly used in allergenic testing.
Approved
Sodium aurotiosulfate
Approved
Experimental
Oxyphenisatin acetate
Oxyphenisatin acetate is the pro-drug of oxyphenisatin (3,3-bis(4-hydroxyphenyl)-1H-indol-2-one). The FDA withdrew its approval for the use of oxyphenisatin acetate due to safety reasons.
Approved
Investigational
Withdrawn
Belumosudil
Belumosudil is used in the treatment of chronic graft-versus-host disease (GVHD) and has been investigated for the treatment of pulmonary arterial hypertension. It is an inhibitor of rho-associated coiled-coil-containing protein kinases (ROCK), with significantly more selectivity for ROCK2 as compared to ROCK1 (IC50 100 nM vs. 3 μM, respectively). In...
Approved
Investigational
Matched Description: … [L34749] In the treatment of GVHD, a condition in which donor T-cells begin to attack recipient tissues …
Nedosiran
Nedosiran is an RNA interference targeting hepatic lactate dehydrogenase, the enzyme responsible for the conversion of glyoxylate to oxalate. Oxalate, particularly calcium oxalate, precipitation is the main cause of kidney stones formation; therefore, blocking the production of oxalate can help alleviate renal symptoms. Nedosiran was approved by the FDA on...
Approved
Investigational
Benzthiazide
Benzthiazide is used to treat hypertension and edema. Like other thiazides, benzthiazide promotes water loss from the body (diuretics). They inhibit Na+/Cl- reabsorption from the distal convoluted tubules in the kidneys. Thiazides also cause loss of potassium and an increase in serum uric acid. Thiazides are often used to treat...
Approved
Bufexamac
Bufexamac is a non-steroidal anti-inflammatory drug (NSAID) under the market name Droxaryl, Malipuran, Paraderm and Parfenac. It is typically administered topically for the treatment of subacute and chronic eczema of the skin, including atopic eczema and other inflammatory dermatoses, as well as sunburn and other minor burns, and itching. It...
Approved
Withdrawn
Matched Description: … Bufexamac is a non-steroidal anti-inflammatory drug (NSAID) under the market name Droxaryl, Malipuran ... discontinued in Canada and the United States, which may be due to undetermined clinical efficacy and a …
Procinonide
Approved
Investigational
Nelarabine
Nelarabine is an antineoplastic agent that is typically used to treat acute T-cell lymphoblastic leukemia, particularly T-cell acute lymphoblastic leukemia (T-ALL) and T-cell lymphoblastic lymphoma (T-LBL), in both adult and pediatric patients whose disease has not responded to or has relapsed following at least two chemotherapy regimens. T-cell acute lymphoblastic...
Approved
Investigational
Matched Description: … Due to the rarity of these T-cell malignancies, nelarabine was first granted orphan drug status and a ... [A2331]
Nelarabine is a purine nucleoside analog converted to its corresponding arabinosylguanine ... Results from 2 phase 2 studies on adult and pediatric T-ALL/T-LBL indicated that nelarabine can yield a …
Ivacaftor
Ivacaftor (also known as Kalydeco or VX-770) is a drug used for the management of Cystic Fibrosis (CF). It is manufactured and distributed by Vertex Pharmaceuticals. It was approved by the Food and Drug Administration on January 31, 2012 , and by Health Canada in late 2012. Ivacaftor is administered...
Approved
Matched Description: … Ivacaftor (also known as Kalydeco or VX-770) is a drug used for the management of Cystic Fibrosis (CF ... [L6841] Ivacaftor is administered as a monotherapy and also administered in combination with other drugs ... [A20298, A20299] As a result, CF patients produce thick, sticky mucus that clogs the ducts of organs …
Dimethicone 410
Dimethicone is a silicone-based polymer used as a moisturizer in different skin OTC products. It is formed by repeated polymeric units of -(CH3)2SiO- with a terminal trimethyl siloxy unit. It is currently recognized by the FDA as a skin protectant OTC ingredient for human use in a concentration of 1-30%....
Approved
Matched Description: … Dimethicone is a silicone-based polymer used as a moisturizer in different skin OTC products. ... [L1769] It is currently recognized by the FDA as a skin protectant OTC ingredient for human use in a ... [A32462] It is formed by repeated polymeric units of -(CH3)2SiO- with a terminal trimethyl siloxy unit …
Trastuzumab
Produced in CHO cell cultures, trastuzumab is a recombinant IgG1 kappa, humanized monoclonal antibody that selectively binds with high affinity in a cell-based assay (Kd = 5 nM) to the extracellular domain of the human epidermal growth factor receptor protein (HER2). It is used as a treatment of human epidermal...
Approved
Investigational
Matched Description: … Produced in CHO cell cultures, trastuzumab is a recombinant IgG1 kappa, humanized monoclonal antibody ... [A40276] that selectively binds with high affinity in a cell-based assay (Kd = 5 nM) to the extracellular ... cancer, where there is a proven amplification of the HER-2 oncogene or over-expression of the HER-2 …
Rifapentine
Rifapentine is an antibiotic drug used in the treatment of tuberculosis. It inhibits DNA-dependent RNA polymerase activity in susceptible cells. Specifically, it interacts with bacterial RNA polymerase but does not inhibit the mammalian enzyme.
Approved
Investigational
Nitisinone
Nitisinone is a synthetic reversible inhibitor of 4-hydroxyphenylpyruvate dioxygenase. It is used in the treatment of hereditary tyrosinemia type 1. It is sold under the brand name Orfadin.
Approved
Investigational
Matched Description: … Nitisinone is a synthetic reversible inhibitor of 4-hydroxyphenylpyruvate dioxygenase. …
Uracil mustard
Nitrogen mustard derivative of uracil. It is a alkylating antineoplastic agent that is used in lymphatic malignancies, and causes mainly gastrointestinal and bone marrow damage.
Approved
Matched Description: … It is a alkylating antineoplastic agent that is used in lymphatic malignancies, and causes mainly gastrointestinal …
Northern brown shrimp
Northern brown shrimp allergenic extract is used in allergenic testing.
Approved
Oxaprozin
Oxaprozin is a non-narcotic, non-steroidal anti-inflammatory drug (NSAID), used to relieve the inflammation, swelling, stiffness, and joint pain associated with osteoarthritis and rheumatoid arthritis.
Approved
Matched Description: … Oxaprozin is a non-narcotic, non-steroidal anti-inflammatory drug (NSAID), used to relieve the inflammation …
Fluclorolone acetonide
Fluclorolone acetonide (INN) or flucloronide (USAN) is a topical corticosteroid. It is marketed under the brand names Cutanit and Topicon.
Approved
Withdrawn
Matched Description: … Fluclorolone acetonide (INN) or flucloronide (USAN) is a topical corticosteroid. …
Displaying drugs 3601 - 3625 of 11853 in total