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Identification
NameIvacaftor
Accession NumberDB08820  (DB05989)
TypeSmall Molecule
GroupsApproved
DescriptionIvacaftor (also known as Kalydeco or VX-770) is a drug for the treatment of cystic fibrosis, developed by Vertex Pharmaceuticals and the Cystic Fibrosis Foundation. FDA approved on January 31, 2012.
Structure
Thumb
Synonyms
Ivacaftorum
Kalydeco
External Identifiers
  • VX-770
Approved Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
KalydecoTablet, film coated150 mg/1OralVertex Pharmaceuticals Incorporated2012-01-31Not applicableUs
KalydecoGranule50 mgOralVertex Pharmaceuticals (Canada) Incorporated2015-09-14Not applicableCanada
KalydecoGranule50 mg/1OralVertex Pharmaceuticals Incorporated2015-03-23Not applicableUs
KalydecoGranule75 mgOralVertex Pharmaceuticals (Canada) Incorporated2015-09-14Not applicableCanada
KalydecoGranule75 mg/1OralVertex Pharmaceuticals Incorporated2015-03-23Not applicableUs
KalydecoTablet150 mgOralVertex Pharmaceuticals (Canada) Incorporated2012-11-27Not applicableCanada
Approved Generic Prescription ProductsNot Available
Approved Over the Counter ProductsNot Available
Unapproved/Other Products Not Available
International BrandsNot Available
Brand mixtures
NameLabellerIngredients
OrkambiVertex Pharmaceuticals (Canada) Incorporated
SaltsNot Available
Categories
UNII1Y740ILL1Z
CAS number873054-44-5
WeightAverage: 392.4907
Monoisotopic: 392.209992772
Chemical FormulaC24H28N2O3
InChI KeyPURKAOJPTOLRMP-UHFFFAOYSA-N
InChI
InChI=1S/C24H28N2O3/c1-23(2,3)16-11-17(24(4,5)6)20(27)12-19(16)26-22(29)15-13-25-18-10-8-7-9-14(18)21(15)28/h7-13,27H,1-6H3,(H,25,28)(H,26,29)
IUPAC Name
N-(2,4-di-tert-butyl-5-hydroxyphenyl)-4-oxo-1,4-dihydroquinoline-3-carboxamide
SMILES
CC(C)(C)C1=CC(=C(O)C=C1NC(=O)C1=CNC2=CC=CC=C2C1=O)C(C)(C)C
Pharmacology
IndicationFor the treatment of cystic fibrosis (CF) in patients age 6 years and older who have a G551D mutation in the CFTR gene.
Structured Indications
PharmacodynamicsIvacaftor is a cystic fibrosis transmembrane conductance regulator (CFTR). In patients with the G551D mutation, Kalydeco, a pill taken two times a day with fat-containing food, helps the protein made by the CFTR gene function better and as a result, improves lung function and other aspects of CF such as increasing weight gain.
Mechanism of actionCystic fibrosis is caused by any one of several defects in a protein, cystic fibrosis transmembrane conductance regulator, which regulates fluid flow within cells and affects the components of sweat, digestive fluids, and mucus. The defect, which is caused by a mutation in the individual's DNA, can be in any of several locations along the protein, each of which interferes with a different function of the protein. One mutation, G551D, lets the CFTR protein reach the epithelial cell surface, but doesn't let it transport chloride through the ion channel. Ivacaftor is a potentiator of the CFTR protein. The CFTR protein is a chloride channel present at the surface of epithelial cells in multiple organs. Ivacaftor facilitates increased chloride transport by potentiating the channel-open probability (or gating) of the G551D-CFTR protein.
TargetKindPharmacological actionActionsOrganismUniProt ID
Cystic fibrosis transmembrane conductance regulatorProteinyes
potentiator
HumanP13569 details
Related Articles
AbsorptionThe pharmacokinetics of ivacaftor is similar between healthy adult volunteers and patients with CF. When given a single oral dose of 150 mg to healthy subjects, the parameters were as follows: Tmax = 4 hours; Cmax = 768 ng/mL; AUC = 10600 ng*hr/mL; Time to steady state, 12 hour dosing = 3-5 days Following repeated doses for ivacaftor, accumulation occurs. When given with a fatty meal, exposure increases 2-4 fold.
Volume of distribution

The mean apparent volume of distribution (Vz/F) of ivacaftor after a single dose of 275 mg of Ivacaftor in the fed state was similar for healthy subjects and patients with CF. After oral administration of 150 mg every 12 hours for 7 days to healthy volunteers in a fed state, the mean (±SD) for apparent volume of distribution was 353 (122) L.

Protein bindingIvacaftor is approximately 99% bound to plasma proteins, primarily to alpha 1-acid glycoprotein and albumin. Ivacaftor does not bind to human red blood cells.
Metabolism

Ivacaftor is extensively metabolized in humans. In vitro and clinical studies indicate that ivacaftor is primarily metabolized by CYP3A. M1 and M6 are the two major metabolites of ivacaftor in humans. M1 has approximately one-sixth the potency of ivacaftor and is considered pharmacologically active. M6 has less than one-fiftieth the potency of ivacaftor and is not considered pharmacologically active.

Route of eliminationFollowing oral administration, the majority of ivacaftor (87.8%) is eliminated in the feces after metabolic conversion. The major metabolites M1 and M6 accounted for approximately 65% of the total dose eliminated with 22% as M1 and 43% as M6. There was negligible urinary excretion of ivacaftor as unchanged parent.
Half life12 hours following a single dose
Clearance

The CL/F (SD) for the 150 mg dose was 17.3 (8.4) L/hr in healthy subjects.

ToxicityThere have been no reports of overdose with Ivacaftor. The highest single dose used in a clinical study was 800 mg in a solution formulation without any treatment-related adverse events.
Affected organisms
  • Humans and other mammals
PathwaysNot Available
SNP Mediated Effects
Interacting Gene/EnzymeSNP RS IDAllele nameDefining changeEffectReference(s)
Cystic fibrosis transmembrane conductance regulator
Gene symbol: CFTR
UniProt: P13569
rs75527207 Not AvailableA allele (G > A)Cystic Fibrosis patients with the A allele will response to ivacaftor23757359
Cystic fibrosis transmembrane conductance regulator
Gene symbol: CFTR
UniProt: P13569
rs75527207 Not AvailableA allele (G > A)Cystic Fibrosis patients with the A allele will response to ivacaftor23891399
SNP Mediated Adverse Drug ReactionsNot Available
Interactions
Drug Interactions
DrugInteractionDrug group
AbirateroneThe serum concentration of Abiraterone can be increased when it is combined with Ivacaftor.Approved
AcebutololThe serum concentration of Acebutolol can be increased when it is combined with Ivacaftor.Approved
AcenocoumarolThe serum concentration of Acenocoumarol can be increased when it is combined with Ivacaftor.Approved
AcetaminophenThe serum concentration of Acetaminophen can be increased when it is combined with Ivacaftor.Approved
Acetylsalicylic acidThe serum concentration of Acetylsalicylic acid can be increased when it is combined with Ivacaftor.Approved, Vet Approved
AdinazolamThe serum concentration of Adinazolam can be increased when it is combined with Ivacaftor.Approved
AfatinibThe serum concentration of Afatinib can be increased when it is combined with Ivacaftor.Approved
AlbendazoleThe serum concentration of Albendazole can be increased when it is combined with Ivacaftor.Approved, Vet Approved
AlclometasoneThe serum concentration of Alclometasone can be increased when it is combined with Ivacaftor.Approved
AldosteroneThe serum concentration of Aldosterone can be increased when it is combined with Ivacaftor.Experimental
AlfentanilThe serum concentration of Alfentanil can be increased when it is combined with Ivacaftor.Approved, Illicit
AlfuzosinThe serum concentration of Alfuzosin can be increased when it is combined with Ivacaftor.Approved, Investigational
AliskirenThe serum concentration of Aliskiren can be increased when it is combined with Ivacaftor.Approved, Investigational
AlitretinoinThe serum concentration of Alitretinoin can be increased when it is combined with Ivacaftor.Approved, Investigational
AllylestrenolThe serum concentration of Allylestrenol can be increased when it is combined with Ivacaftor.Approved
AlmotriptanThe serum concentration of Almotriptan can be increased when it is combined with Ivacaftor.Approved, Investigational
AlogliptinThe serum concentration of Alogliptin can be increased when it is combined with Ivacaftor.Approved
AlosetronThe serum concentration of Alosetron can be increased when it is combined with Ivacaftor.Approved, Withdrawn
AlprazolamThe serum concentration of Alprazolam can be increased when it is combined with Ivacaftor.Approved, Illicit, Investigational
AmbrisentanThe serum concentration of Ambrisentan can be increased when it is combined with Ivacaftor.Approved, Investigational
AmbroxolThe serum concentration of Ambroxol can be increased when it is combined with Ivacaftor.Approved
AminophenazoneThe serum concentration of Aminophenazone can be increased when it is combined with Ivacaftor.Approved, Withdrawn
AminophyllineThe serum concentration of Aminophylline can be increased when it is combined with Ivacaftor.Approved
AmiodaroneThe serum concentration of Ivacaftor can be increased when it is combined with Amiodarone.Approved, Investigational
AmitriptylineThe serum concentration of Amitriptyline can be increased when it is combined with Ivacaftor.Approved
AmlodipineThe serum concentration of Amlodipine can be increased when it is combined with Ivacaftor.Approved
AmprenavirThe serum concentration of Amprenavir can be increased when it is combined with Ivacaftor.Approved
AntipyrineThe serum concentration of Antipyrine can be increased when it is combined with Ivacaftor.Approved
ApixabanThe serum concentration of Apixaban can be increased when it is combined with Ivacaftor.Approved
ApremilastThe serum concentration of Apremilast can be increased when it is combined with Ivacaftor.Approved, Investigational
AprepitantThe serum concentration of Ivacaftor can be increased when it is combined with Aprepitant.Approved, Investigational
ArgatrobanThe serum concentration of Argatroban can be increased when it is combined with Ivacaftor.Approved, Investigational
AripiprazoleThe serum concentration of Aripiprazole can be increased when it is combined with Ivacaftor.Approved, Investigational
Arsenic trioxideThe serum concentration of Arsenic trioxide can be increased when it is combined with Ivacaftor.Approved, Investigational
ArtemetherThe serum concentration of Artemether can be increased when it is combined with Ivacaftor.Approved
AsenapineThe serum concentration of Asenapine can be increased when it is combined with Ivacaftor.Approved
AstemizoleThe serum concentration of Astemizole can be increased when it is combined with Ivacaftor.Approved, Withdrawn
AtazanavirThe serum concentration of Ivacaftor can be increased when it is combined with Atazanavir.Approved, Investigational
AtenololThe serum concentration of Atenolol can be increased when it is combined with Ivacaftor.Approved
AtomoxetineThe serum concentration of Ivacaftor can be increased when it is combined with Atomoxetine.Approved
AtorvastatinThe serum concentration of Atorvastatin can be increased when it is combined with Ivacaftor.Approved
AvanafilThe serum concentration of Avanafil can be increased when it is combined with Ivacaftor.Approved
AxitinibThe serum concentration of Axitinib can be increased when it is combined with Ivacaftor.Approved, Investigational
AzelastineThe serum concentration of Azelastine can be increased when it is combined with Ivacaftor.Approved
AzithromycinThe serum concentration of Azithromycin can be increased when it is combined with Ivacaftor.Approved
BanoxantroneThe serum concentration of Banoxantrone can be increased when it is combined with Ivacaftor.Investigational
BedaquilineThe serum concentration of Bedaquiline can be increased when it is combined with Ivacaftor.Approved
BenzphetamineThe serum concentration of Benzphetamine can be increased when it is combined with Ivacaftor.Approved, Illicit
Benzyl alcoholThe serum concentration of Benzyl alcohol can be increased when it is combined with Ivacaftor.Approved
BetamethasoneThe serum concentration of Betamethasone can be increased when it is combined with Ivacaftor.Approved, Vet Approved
BexaroteneThe serum concentration of Bexarotene can be increased when it is combined with Ivacaftor.Approved, Investigational
BezafibrateThe serum concentration of Bezafibrate can be increased when it is combined with Ivacaftor.Approved
BicalutamideThe serum concentration of Bicalutamide can be increased when it is combined with Ivacaftor.Approved
BisoprololThe serum concentration of Bisoprolol can be increased when it is combined with Ivacaftor.Approved
BoceprevirThe serum concentration of Ivacaftor can be increased when it is combined with Boceprevir.Approved
BortezomibThe serum concentration of Ivacaftor can be increased when it is combined with Bortezomib.Approved, Investigational
BosentanThe serum concentration of Bosentan can be increased when it is combined with Ivacaftor.Approved, Investigational
BosutinibThe serum concentration of Bosutinib can be increased when it is combined with Ivacaftor.Approved
Brentuximab vedotinThe serum concentration of Brentuximab vedotin can be increased when it is combined with Ivacaftor.Approved
BrexpiprazoleThe serum concentration of Brexpiprazole can be increased when it is combined with Ivacaftor.Approved
BrinzolamideThe serum concentration of Brinzolamide can be increased when it is combined with Ivacaftor.Approved
BromazepamThe serum concentration of Bromazepam can be increased when it is combined with Ivacaftor.Approved, Illicit
BromocriptineThe serum concentration of Bromocriptine can be increased when it is combined with Ivacaftor.Approved, Investigational
BrompheniramineThe serum concentration of Brompheniramine can be increased when it is combined with Ivacaftor.Approved
BudesonideThe serum concentration of Budesonide can be increased when it is combined with Ivacaftor.Approved
BupivacaineThe serum concentration of Bupivacaine can be increased when it is combined with Ivacaftor.Approved, Investigational
BuprenorphineThe serum concentration of Buprenorphine can be increased when it is combined with Ivacaftor.Approved, Illicit, Investigational, Vet Approved
BupropionThe serum concentration of Bupropion can be increased when it is combined with Ivacaftor.Approved
BuspironeThe serum concentration of Buspirone can be increased when it is combined with Ivacaftor.Approved, Investigational
BusulfanThe serum concentration of Busulfan can be increased when it is combined with Ivacaftor.Approved, Investigational
CabazitaxelThe serum concentration of Cabazitaxel can be increased when it is combined with Ivacaftor.Approved
CabergolineThe serum concentration of Cabergoline can be increased when it is combined with Ivacaftor.Approved
CabozantinibThe serum concentration of Cabozantinib can be increased when it is combined with Ivacaftor.Approved
CaffeineThe serum concentration of Caffeine can be increased when it is combined with Ivacaftor.Approved
CalcitriolThe serum concentration of Calcitriol can be increased when it is combined with Ivacaftor.Approved, Nutraceutical
CamptothecinThe serum concentration of Camptothecin can be increased when it is combined with Ivacaftor.Experimental
CanagliflozinThe serum concentration of Canagliflozin can be increased when it is combined with Ivacaftor.Approved
CarbamazepineThe serum concentration of Ivacaftor can be decreased when it is combined with Carbamazepine.Approved, Investigational
CarbinoxamineThe serum concentration of Carbinoxamine can be increased when it is combined with Ivacaftor.Approved
CarfilzomibThe serum concentration of Carfilzomib can be increased when it is combined with Ivacaftor.Approved
CariprazineThe serum concentration of Cariprazine can be increased when it is combined with Ivacaftor.Approved
CarvedilolThe serum concentration of Carvedilol can be increased when it is combined with Ivacaftor.Approved, Investigational
CelecoxibThe serum concentration of Celecoxib can be increased when it is combined with Ivacaftor.Approved, Investigational
CeliprololThe serum concentration of Celiprolol can be increased when it is combined with Ivacaftor.Approved, Investigational
CephalexinThe serum concentration of Cephalexin can be increased when it is combined with Ivacaftor.Approved, Vet Approved
CeritinibThe serum concentration of Ivacaftor can be increased when it is combined with Ceritinib.Approved
CerivastatinThe serum concentration of Cerivastatin can be increased when it is combined with Ivacaftor.Withdrawn
CevimelineThe serum concentration of Cevimeline can be increased when it is combined with Ivacaftor.Approved
Chenodeoxycholic acidThe serum concentration of Chenodeoxycholic acid can be increased when it is combined with Ivacaftor.Approved
ChlordiazepoxideThe serum concentration of Chlordiazepoxide can be increased when it is combined with Ivacaftor.Approved, Illicit
ChloroquineThe serum concentration of Chloroquine can be increased when it is combined with Ivacaftor.Approved, Vet Approved
ChlorphenamineThe serum concentration of Chlorphenamine can be increased when it is combined with Ivacaftor.Approved
ChlorpromazineThe serum concentration of Chlorpromazine can be increased when it is combined with Ivacaftor.Approved, Vet Approved
ChlorzoxazoneThe serum concentration of Chlorzoxazone can be increased when it is combined with Ivacaftor.Approved
CholecalciferolThe serum concentration of Cholecalciferol can be increased when it is combined with Ivacaftor.Approved, Nutraceutical
CiclesonideThe serum concentration of Ciclesonide can be increased when it is combined with Ivacaftor.Approved, Investigational
CilostazolThe serum concentration of Cilostazol can be increased when it is combined with Ivacaftor.Approved
CimetidineThe serum concentration of Cimetidine can be increased when it is combined with Ivacaftor.Approved
CinacalcetThe serum concentration of Cinacalcet can be increased when it is combined with Ivacaftor.Approved
CiprofloxacinThe serum concentration of Ciprofloxacin can be increased when it is combined with Ivacaftor.Approved, Investigational
CisaprideThe serum concentration of Cisapride can be increased when it is combined with Ivacaftor.Approved, Investigational, Withdrawn
CisplatinThe serum concentration of Cisplatin can be increased when it is combined with Ivacaftor.Approved
CitalopramThe serum concentration of Citalopram can be increased when it is combined with Ivacaftor.Approved
ClarithromycinThe serum concentration of Ivacaftor can be increased when it is combined with Clarithromycin.Approved
ClemastineThe serum concentration of Ivacaftor can be increased when it is combined with Clemastine.Approved
ClindamycinThe serum concentration of Clindamycin can be increased when it is combined with Ivacaftor.Approved, Vet Approved
ClobazamThe serum concentration of Clobazam can be increased when it is combined with Ivacaftor.Approved, Illicit
ClofazimineThe serum concentration of Clofazimine can be increased when it is combined with Ivacaftor.Approved, Investigational
ClofibrateThe serum concentration of Clofibrate can be increased when it is combined with Ivacaftor.Approved
clomethiazoleThe serum concentration of clomethiazole can be increased when it is combined with Ivacaftor.Investigational
ClomifeneThe serum concentration of Clomifene can be increased when it is combined with Ivacaftor.Approved, Investigational
ClomipramineThe serum concentration of Clomipramine can be increased when it is combined with Ivacaftor.Approved, Vet Approved
ClonazepamThe serum concentration of Clonazepam can be increased when it is combined with Ivacaftor.Approved, Illicit
ClonidineThe serum concentration of Clonidine can be increased when it is combined with Ivacaftor.Approved
ClopidogrelThe serum concentration of Clopidogrel can be increased when it is combined with Ivacaftor.Approved, Nutraceutical
ClorazepateThe serum concentration of Clorazepate can be increased when it is combined with Ivacaftor.Approved, Illicit
ClotiazepamThe serum concentration of Clotiazepam can be increased when it is combined with Ivacaftor.Approved, Illicit
ClotrimazoleThe serum concentration of Ivacaftor can be increased when it is combined with Clotrimazole.Approved, Vet Approved
ClozapineThe serum concentration of Clozapine can be increased when it is combined with Ivacaftor.Approved
CobicistatThe serum concentration of Ivacaftor can be increased when it is combined with Cobicistat.Approved
CobimetinibThe serum concentration of Cobimetinib can be increased when it is combined with Ivacaftor.Approved
CocaineThe serum concentration of Cocaine can be increased when it is combined with Ivacaftor.Approved, Illicit
CodeineThe serum concentration of Codeine can be increased when it is combined with Ivacaftor.Approved, Illicit
ColchicineThe serum concentration of Colchicine can be increased when it is combined with Ivacaftor.Approved
ConivaptanThe serum concentration of Ivacaftor can be increased when it is combined with Conivaptan.Approved, Investigational
Conjugated Equine EstrogensThe serum concentration of Conjugated Equine Estrogens can be increased when it is combined with Ivacaftor.Approved
Cortisone acetateThe serum concentration of Cortisone acetate can be increased when it is combined with Ivacaftor.Approved
CrizotinibThe serum concentration of Ivacaftor can be increased when it is combined with Crizotinib.Approved
CyclobenzaprineThe serum concentration of Cyclobenzaprine can be increased when it is combined with Ivacaftor.Approved
CyclophosphamideThe serum concentration of Cyclophosphamide can be increased when it is combined with Ivacaftor.Approved, Investigational
CyclosporineThe serum concentration of Ivacaftor can be increased when it is combined with Cyclosporine.Approved, Investigational, Vet Approved
CytarabineThe serum concentration of Cytarabine can be increased when it is combined with Ivacaftor.Approved, Investigational
Dabigatran etexilateThe serum concentration of the active metabolites of Dabigatran etexilate can be increased when Dabigatran etexilate is used in combination with Ivacaftor.Approved
DabrafenibThe serum concentration of Ivacaftor can be decreased when it is combined with Dabrafenib.Approved
DaclatasvirThe serum concentration of Daclatasvir can be increased when it is combined with Ivacaftor.Approved
DactinomycinThe serum concentration of Dactinomycin can be increased when it is combined with Ivacaftor.Approved
DantroleneThe serum concentration of Dantrolene can be increased when it is combined with Ivacaftor.Approved
DapagliflozinThe serum concentration of Dapagliflozin can be increased when it is combined with Ivacaftor.Approved
DapsoneThe serum concentration of Dapsone can be increased when it is combined with Ivacaftor.Approved, Investigational
DarifenacinThe serum concentration of Darifenacin can be increased when it is combined with Ivacaftor.Approved, Investigational
DarunavirThe serum concentration of Ivacaftor can be increased when it is combined with Darunavir.Approved
DasabuvirThe serum concentration of Dasabuvir can be increased when it is combined with Ivacaftor.Approved
DasatinibThe serum concentration of Dasatinib can be increased when it is combined with Ivacaftor.Approved, Investigational
DaunorubicinThe serum concentration of Daunorubicin can be increased when it is combined with Ivacaftor.Approved
DebrisoquinThe serum concentration of Debrisoquin can be increased when it is combined with Ivacaftor.Approved
DeferasiroxThe serum concentration of Ivacaftor can be decreased when it is combined with Deferasirox.Approved, Investigational
DelavirdineThe serum concentration of Ivacaftor can be increased when it is combined with Delavirdine.Approved
DesvenlafaxineThe serum concentration of Desvenlafaxine can be increased when it is combined with Ivacaftor.Approved
DexamethasoneThe serum concentration of Dexamethasone can be increased when it is combined with Ivacaftor.Approved, Investigational, Vet Approved
DextromethorphanThe serum concentration of Dextromethorphan can be increased when it is combined with Ivacaftor.Approved
DextropropoxypheneThe serum concentration of Dextropropoxyphene can be increased when it is combined with Ivacaftor.Approved, Illicit, Withdrawn
DiazepamThe serum concentration of Diazepam can be increased when it is combined with Ivacaftor.Approved, Illicit, Vet Approved
DiclofenacThe serum concentration of Diclofenac can be increased when it is combined with Ivacaftor.Approved, Vet Approved
DiethylstilbestrolThe serum concentration of Diethylstilbestrol can be increased when it is combined with Ivacaftor.Approved
DigitoxinThe serum concentration of Digitoxin can be increased when it is combined with Ivacaftor.Approved
DigoxinThe serum concentration of Digoxin can be increased when it is combined with Ivacaftor.Approved
DihydrocodeineThe serum concentration of Dihydrocodeine can be increased when it is combined with Ivacaftor.Approved, Illicit
DihydroergotamineThe serum concentration of Ivacaftor can be increased when it is combined with Dihydroergotamine.Approved
DihydrotestosteroneThe serum concentration of Dihydrotestosterone can be increased when it is combined with Ivacaftor.Illicit
DiltiazemThe serum concentration of Ivacaftor can be increased when it is combined with Diltiazem.Approved
DipyridamoleThe serum concentration of Dipyridamole can be increased when it is combined with Ivacaftor.Approved
DisopyramideThe serum concentration of Disopyramide can be increased when it is combined with Ivacaftor.Approved
DisulfiramThe serum concentration of Disulfiram can be increased when it is combined with Ivacaftor.Approved
DocetaxelThe serum concentration of Docetaxel can be increased when it is combined with Ivacaftor.Approved, Investigational
DofetilideThe serum concentration of Dofetilide can be increased when it is combined with Ivacaftor.Approved
DolasetronThe serum concentration of Dolasetron can be increased when it is combined with Ivacaftor.Approved
DomperidoneThe serum concentration of Domperidone can be increased when it is combined with Ivacaftor.Approved, Investigational, Vet Approved
DonepezilThe serum concentration of Donepezil can be increased when it is combined with Ivacaftor.Approved
DorzolamideThe serum concentration of Dorzolamide can be increased when it is combined with Ivacaftor.Approved
DoxepinThe serum concentration of Doxepin can be increased when it is combined with Ivacaftor.Approved
DoxorubicinThe serum concentration of Doxorubicin can be increased when it is combined with Ivacaftor.Approved, Investigational
DoxycyclineThe serum concentration of Ivacaftor can be increased when it is combined with Doxycycline.Approved, Investigational, Vet Approved
DronabinolThe serum concentration of Dronabinol can be increased when it is combined with Ivacaftor.Approved, Illicit
DronedaroneThe serum concentration of Ivacaftor can be increased when it is combined with Dronedarone.Approved
DutasterideThe serum concentration of Dutasteride can be increased when it is combined with Ivacaftor.Approved, Investigational
EdoxabanThe serum concentration of Edoxaban can be increased when it is combined with Ivacaftor.Approved
EfavirenzThe serum concentration of Efavirenz can be increased when it is combined with Ivacaftor.Approved, Investigational
EletriptanThe serum concentration of Eletriptan can be increased when it is combined with Ivacaftor.Approved, Investigational
EliglustatThe serum concentration of Eliglustat can be increased when it is combined with Ivacaftor.Approved
ElvitegravirThe serum concentration of Elvitegravir can be increased when it is combined with Ivacaftor.Approved
EnalaprilThe serum concentration of Enalapril can be increased when it is combined with Ivacaftor.Approved, Vet Approved
EnzalutamideThe serum concentration of Ivacaftor can be decreased when it is combined with Enzalutamide.Approved
EpinastineThe serum concentration of Epinastine can be increased when it is combined with Ivacaftor.Approved, Investigational
EplerenoneThe serum concentration of Eplerenone can be increased when it is combined with Ivacaftor.Approved
ErgocalciferolThe serum concentration of Ergocalciferol can be increased when it is combined with Ivacaftor.Approved, Nutraceutical
Ergoloid mesylateThe serum concentration of Ergoloid mesylate can be increased when it is combined with Ivacaftor.Approved
ErgonovineThe serum concentration of Ergonovine can be increased when it is combined with Ivacaftor.Approved
ErgotamineThe serum concentration of Ergotamine can be increased when it is combined with Ivacaftor.Approved
ErlotinibThe serum concentration of Erlotinib can be increased when it is combined with Ivacaftor.Approved, Investigational
ErythromycinThe serum concentration of Ivacaftor can be increased when it is combined with Erythromycin.Approved, Vet Approved
EscitalopramThe serum concentration of Escitalopram can be increased when it is combined with Ivacaftor.Approved, Investigational
Eslicarbazepine acetateThe serum concentration of Ivacaftor can be decreased when it is combined with Eslicarbazepine acetate.Approved
EsomeprazoleThe serum concentration of Esomeprazole can be increased when it is combined with Ivacaftor.Approved, Investigational
EstazolamThe serum concentration of Estazolam can be increased when it is combined with Ivacaftor.Approved, Illicit
EstradiolThe serum concentration of Estradiol can be increased when it is combined with Ivacaftor.Approved, Investigational, Vet Approved
Estradiol valerate/DienogestThe serum concentration of Estradiol valerate/Dienogest can be increased when it is combined with Ivacaftor.Approved
EstramustineThe serum concentration of Estramustine can be increased when it is combined with Ivacaftor.Approved
EstriolThe serum concentration of Estriol can be increased when it is combined with Ivacaftor.Approved, Vet Approved
EstroneThe serum concentration of Estrone can be increased when it is combined with Ivacaftor.Approved
Estrone sulfateThe serum concentration of Estrone sulfate can be increased when it is combined with Ivacaftor.Approved
EszopicloneThe serum concentration of Eszopiclone can be increased when it is combined with Ivacaftor.Approved
EthanolThe serum concentration of Ethanol can be increased when it is combined with Ivacaftor.Approved
Ethinyl EstradiolThe serum concentration of Ethinyl Estradiol can be increased when it is combined with Ivacaftor.Approved
EthosuximideThe serum concentration of Ethosuximide can be increased when it is combined with Ivacaftor.Approved
EthylmorphineThe serum concentration of Ethylmorphine can be increased when it is combined with Ivacaftor.Approved, Illicit
EtonogestrelThe serum concentration of Etonogestrel can be increased when it is combined with Ivacaftor.Approved, Investigational
EtoposideThe serum concentration of Etoposide can be increased when it is combined with Ivacaftor.Approved
EtoricoxibThe serum concentration of Etoricoxib can be increased when it is combined with Ivacaftor.Approved, Investigational
EtravirineThe serum concentration of Etravirine can be increased when it is combined with Ivacaftor.Approved
EverolimusThe serum concentration of Everolimus can be increased when it is combined with Ivacaftor.Approved
ExemestaneThe serum concentration of Exemestane can be increased when it is combined with Ivacaftor.Approved, Investigational
EzetimibeThe serum concentration of Ezetimibe can be increased when it is combined with Ivacaftor.Approved
FamciclovirThe serum concentration of Famciclovir can be increased when it is combined with Ivacaftor.Approved
FelbamateThe serum concentration of Felbamate can be increased when it is combined with Ivacaftor.Approved
FelodipineThe serum concentration of Felodipine can be increased when it is combined with Ivacaftor.Approved, Investigational
FenofibrateThe serum concentration of Fenofibrate can be increased when it is combined with Ivacaftor.Approved
FentanylThe serum concentration of Fentanyl can be increased when it is combined with Ivacaftor.Approved, Illicit, Investigational, Vet Approved
FesoterodineThe serum concentration of Fesoterodine can be increased when it is combined with Ivacaftor.Approved
FexofenadineThe serum concentration of Fexofenadine can be increased when it is combined with Ivacaftor.Approved
FidaxomicinThe serum concentration of Fidaxomicin can be increased when it is combined with Ivacaftor.Approved
FinasterideThe serum concentration of Finasteride can be increased when it is combined with Ivacaftor.Approved
FingolimodThe serum concentration of Fingolimod can be increased when it is combined with Ivacaftor.Approved, Investigational
FlibanserinThe serum concentration of Flibanserin can be increased when it is combined with Ivacaftor.Approved
FluconazoleThe serum concentration of Ivacaftor can be increased when it is combined with Fluconazole.Approved
FlunisolideThe serum concentration of Flunisolide can be increased when it is combined with Ivacaftor.Approved, Investigational
FlunitrazepamThe serum concentration of Flunitrazepam can be increased when it is combined with Ivacaftor.Approved, Illicit
FluorometholoneThe serum concentration of Fluorometholone can be increased when it is combined with Ivacaftor.Approved
FluoxetineThe serum concentration of Fluoxetine can be increased when it is combined with Ivacaftor.Approved, Vet Approved
FlurazepamThe serum concentration of Flurazepam can be increased when it is combined with Ivacaftor.Approved, Illicit
FlutamideThe serum concentration of Flutamide can be increased when it is combined with Ivacaftor.Approved
Fluticasone furoateThe serum concentration of Fluticasone furoate can be increased when it is combined with Ivacaftor.Approved
Fluticasone PropionateThe serum concentration of Fluticasone Propionate can be increased when it is combined with Ivacaftor.Approved
FluvastatinThe serum concentration of Fluvastatin can be increased when it is combined with Ivacaftor.Approved
FluvoxamineThe serum concentration of Ivacaftor can be increased when it is combined with Fluvoxamine.Approved, Investigational
FosamprenavirThe serum concentration of Ivacaftor can be increased when it is combined with Fosamprenavir.Approved
FosaprepitantThe serum concentration of Ivacaftor can be increased when it is combined with Fosaprepitant.Approved
FosphenytoinThe serum concentration of Ivacaftor can be decreased when it is combined with Fosphenytoin.Approved
FulvestrantThe serum concentration of Fulvestrant can be increased when it is combined with Ivacaftor.Approved, Investigational
Fusidic AcidThe serum concentration of Ivacaftor can be increased when it is combined with Fusidic Acid.Approved
GalantamineThe serum concentration of Galantamine can be increased when it is combined with Ivacaftor.Approved
GefitinibThe serum concentration of Gefitinib can be increased when it is combined with Ivacaftor.Approved, Investigational
GemcitabineThe serum concentration of Gemcitabine can be increased when it is combined with Ivacaftor.Approved
GemfibrozilThe serum concentration of Gemfibrozil can be increased when it is combined with Ivacaftor.Approved
GlipizideThe serum concentration of Glipizide can be increased when it is combined with Ivacaftor.Approved
GlyburideThe serum concentration of Glyburide can be increased when it is combined with Ivacaftor.Approved
GranisetronThe serum concentration of Granisetron can be increased when it is combined with Ivacaftor.Approved, Investigational
GrazoprevirThe serum concentration of Grazoprevir can be increased when it is combined with Ivacaftor.Approved
GrepafloxacinThe serum concentration of Grepafloxacin can be increased when it is combined with Ivacaftor.Withdrawn
GuanfacineThe serum concentration of Guanfacine can be increased when it is combined with Ivacaftor.Approved, Investigational
HalofantrineThe serum concentration of Halofantrine can be increased when it is combined with Ivacaftor.Approved
HaloperidolThe serum concentration of Haloperidol can be increased when it is combined with Ivacaftor.Approved
HalothaneThe serum concentration of Halothane can be increased when it is combined with Ivacaftor.Approved, Vet Approved
HexobarbitalThe serum concentration of Hexobarbital can be increased when it is combined with Ivacaftor.Approved
Histamine PhosphateThe serum concentration of Histamine Phosphate can be increased when it is combined with Ivacaftor.Approved
HydrocodoneThe serum concentration of Hydrocodone can be increased when it is combined with Ivacaftor.Approved, Illicit
HydrocortisoneThe serum concentration of Hydrocortisone can be increased when it is combined with Ivacaftor.Approved, Vet Approved
HydromorphoneThe serum concentration of Hydromorphone can be increased when it is combined with Ivacaftor.Approved, Illicit
Hydroxyprogesterone caproateThe serum concentration of Hydroxyprogesterone caproate can be increased when it is combined with Ivacaftor.Approved
IbrutinibThe serum concentration of Ibrutinib can be increased when it is combined with Ivacaftor.Approved
IbuprofenThe serum concentration of Ibuprofen can be increased when it is combined with Ivacaftor.Approved
IdelalisibThe serum concentration of Ivacaftor can be increased when it is combined with Idelalisib.Approved
IfosfamideThe serum concentration of Ifosfamide can be increased when it is combined with Ivacaftor.Approved
IloperidoneThe serum concentration of Iloperidone can be increased when it is combined with Ivacaftor.Approved
ImatinibThe serum concentration of Ivacaftor can be increased when it is combined with Imatinib.Approved
ImipramineThe serum concentration of Imipramine can be increased when it is combined with Ivacaftor.Approved
ImiquimodThe serum concentration of Imiquimod can be increased when it is combined with Ivacaftor.Approved, Investigational
IndacaterolThe serum concentration of Indacaterol can be increased when it is combined with Ivacaftor.Approved
IndapamideThe serum concentration of Indapamide can be increased when it is combined with Ivacaftor.Approved
IndinavirThe serum concentration of Ivacaftor can be increased when it is combined with Indinavir.Approved
IndomethacinThe serum concentration of Indomethacin can be increased when it is combined with Ivacaftor.Approved, Investigational
Ipratropium bromideThe serum concentration of Ipratropium bromide can be increased when it is combined with Ivacaftor.Approved
IrinotecanThe serum concentration of Irinotecan can be increased when it is combined with Ivacaftor.Approved, Investigational
IsavuconazoniumThe serum concentration of Ivacaftor can be increased when it is combined with Isavuconazonium.Approved, Investigational
Isosorbide DinitrateThe serum concentration of Isosorbide Dinitrate can be increased when it is combined with Ivacaftor.Approved
Isosorbide MononitrateThe serum concentration of Isosorbide Mononitrate can be increased when it is combined with Ivacaftor.Approved
IsradipineThe serum concentration of Ivacaftor can be increased when it is combined with Isradipine.Approved
ItraconazoleThe serum concentration of Ivacaftor can be increased when it is combined with Itraconazole.Approved, Investigational
IvabradineThe serum concentration of Ivabradine can be increased when it is combined with Ivacaftor.Approved
IvermectinThe serum concentration of Ivermectin can be increased when it is combined with Ivacaftor.Approved, Vet Approved
IxabepiloneThe serum concentration of Ixabepilone can be increased when it is combined with Ivacaftor.Approved, Investigational
IxazomibThe serum concentration of Ixazomib can be increased when it is combined with Ivacaftor.Approved
KetamineThe serum concentration of Ketamine can be increased when it is combined with Ivacaftor.Approved, Vet Approved
KetazolamThe serum concentration of Ketazolam can be increased when it is combined with Ivacaftor.Approved
KetobemidoneThe serum concentration of Ketobemidone can be increased when it is combined with Ivacaftor.Approved
KetoconazoleThe serum concentration of Ivacaftor can be increased when it is combined with Ketoconazole.Approved, Investigational
LamivudineThe serum concentration of Lamivudine can be increased when it is combined with Ivacaftor.Approved, Investigational
LamotrigineThe serum concentration of Lamotrigine can be increased when it is combined with Ivacaftor.Approved, Investigational
LansoprazoleThe serum concentration of Lansoprazole can be increased when it is combined with Ivacaftor.Approved, Investigational
LapatinibThe serum concentration of Lapatinib can be increased when it is combined with Ivacaftor.Approved, Investigational
LaquinimodThe serum concentration of Laquinimod can be increased when it is combined with Ivacaftor.Investigational
LedipasvirThe serum concentration of Ledipasvir can be increased when it is combined with Ivacaftor.Approved
LenalidomideThe serum concentration of Lenalidomide can be increased when it is combined with Ivacaftor.Approved
LenvatinibThe serum concentration of Lenvatinib can be increased when it is combined with Ivacaftor.Approved
LercanidipineThe serum concentration of Lercanidipine can be increased when it is combined with Ivacaftor.Approved, Investigational
LetrozoleThe serum concentration of Letrozole can be increased when it is combined with Ivacaftor.Approved, Investigational
LevetiracetamThe serum concentration of Levetiracetam can be increased when it is combined with Ivacaftor.Approved, Investigational
LevobupivacaineThe serum concentration of Levobupivacaine can be increased when it is combined with Ivacaftor.Approved
LevocetirizineThe serum concentration of Levocetirizine can be increased when it is combined with Ivacaftor.Approved
LevofloxacinThe serum concentration of Levofloxacin can be increased when it is combined with Ivacaftor.Approved, Investigational
Levomethadyl AcetateThe serum concentration of Levomethadyl Acetate can be increased when it is combined with Ivacaftor.Approved
LevomilnacipranThe serum concentration of Levomilnacipran can be increased when it is combined with Ivacaftor.Approved
LevonorgestrelThe serum concentration of Levonorgestrel can be increased when it is combined with Ivacaftor.Approved, Investigational
LevothyroxineThe serum concentration of Levothyroxine can be increased when it is combined with Ivacaftor.Approved
LidocaineThe serum concentration of Lidocaine can be increased when it is combined with Ivacaftor.Approved, Vet Approved
LinagliptinThe serum concentration of Linagliptin can be increased when it is combined with Ivacaftor.Approved
LisurideThe serum concentration of Lisuride can be increased when it is combined with Ivacaftor.Approved
LomitapideThe serum concentration of Lomitapide can be increased when it is combined with Ivacaftor.Approved
LoperamideThe serum concentration of Loperamide can be increased when it is combined with Ivacaftor.Approved
LopinavirThe serum concentration of Ivacaftor can be increased when it is combined with Lopinavir.Approved
LoratadineThe serum concentration of Loratadine can be increased when it is combined with Ivacaftor.Approved
LorcaserinThe serum concentration of Lorcaserin can be increased when it is combined with Ivacaftor.Approved
LosartanThe serum concentration of Losartan can be increased when it is combined with Ivacaftor.Approved
LovastatinThe serum concentration of Ivacaftor can be increased when it is combined with Lovastatin.Approved, Investigational
LuliconazoleThe serum concentration of Ivacaftor can be increased when it is combined with Luliconazole.Approved
LumacaftorThe serum concentration of Ivacaftor can be decreased when it is combined with Lumacaftor.Approved
LumefantrineThe serum concentration of Lumefantrine can be increased when it is combined with Ivacaftor.Approved
LurasidoneThe serum concentration of Lurasidone can be increased when it is combined with Ivacaftor.Approved
MacitentanThe serum concentration of Macitentan can be increased when it is combined with Ivacaftor.Approved
MannitolThe serum concentration of Mannitol can be increased when it is combined with Ivacaftor.Approved, Investigational
MaravirocThe serum concentration of Maraviroc can be increased when it is combined with Ivacaftor.Approved, Investigational
MebendazoleThe serum concentration of Mebendazole can be increased when it is combined with Ivacaftor.Approved, Vet Approved
Medroxyprogesterone acetateThe serum concentration of Medroxyprogesterone acetate can be increased when it is combined with Ivacaftor.Approved, Investigational
MefloquineThe serum concentration of Mefloquine can be increased when it is combined with Ivacaftor.Approved
MeloxicamThe serum concentration of Meloxicam can be increased when it is combined with Ivacaftor.Approved, Vet Approved
MethadoneThe serum concentration of Methadone can be increased when it is combined with Ivacaftor.Approved
MethaqualoneThe serum concentration of Methaqualone can be increased when it is combined with Ivacaftor.Illicit, Withdrawn
MethotrexateThe serum concentration of Methotrexate can be increased when it is combined with Ivacaftor.Approved
MethoxsalenThe serum concentration of Methoxsalen can be increased when it is combined with Ivacaftor.Approved
MethoxyfluraneThe serum concentration of Methoxyflurane can be increased when it is combined with Ivacaftor.Approved, Vet Approved
MethylprednisoloneThe serum concentration of Methylprednisolone can be increased when it is combined with Ivacaftor.Approved, Vet Approved
MethyltestosteroneThe serum concentration of Methyltestosterone can be increased when it is combined with Ivacaftor.Approved
MetoprololThe serum concentration of Metoprolol can be increased when it is combined with Ivacaftor.Approved, Investigational
MetronidazoleThe serum concentration of Metronidazole can be increased when it is combined with Ivacaftor.Approved
MexiletineThe serum concentration of Mexiletine can be increased when it is combined with Ivacaftor.Approved
MianserinThe serum concentration of Mianserin can be increased when it is combined with Ivacaftor.Approved
MibefradilThe serum concentration of Mibefradil can be increased when it is combined with Ivacaftor.Withdrawn
MiconazoleThe serum concentration of Miconazole can be increased when it is combined with Ivacaftor.Approved, Investigational, Vet Approved
MidazolamThe serum concentration of Midazolam can be increased when it is combined with Ivacaftor.Approved, Illicit
MifepristoneThe serum concentration of Ivacaftor can be increased when it is combined with Mifepristone.Approved, Investigational
MirabegronThe serum concentration of Mirabegron can be increased when it is combined with Ivacaftor.Approved
MirtazapineThe serum concentration of Mirtazapine can be increased when it is combined with Ivacaftor.Approved
MitotaneThe serum concentration of Ivacaftor can be decreased when it is combined with Mitotane.Approved
MitoxantroneThe serum concentration of Mitoxantrone can be increased when it is combined with Ivacaftor.Approved, Investigational
ModafinilThe serum concentration of Modafinil can be increased when it is combined with Ivacaftor.Approved, Investigational
MontelukastThe serum concentration of Montelukast can be increased when it is combined with Ivacaftor.Approved
MorphineThe serum concentration of Morphine can be increased when it is combined with Ivacaftor.Approved, Investigational
Mycophenolate mofetilThe serum concentration of Mycophenolate mofetil can be increased when it is combined with Ivacaftor.Approved, Investigational
NadololThe serum concentration of Nadolol can be increased when it is combined with Ivacaftor.Approved
NafcillinThe serum concentration of Ivacaftor can be decreased when it is combined with Nafcillin.Approved
NaloxegolThe serum concentration of Naloxegol can be increased when it is combined with Ivacaftor.Approved
NaloxoneThe serum concentration of Naloxone can be increased when it is combined with Ivacaftor.Approved, Vet Approved
NateglinideThe serum concentration of Nateglinide can be increased when it is combined with Ivacaftor.Approved, Investigational
NefazodoneThe serum concentration of Ivacaftor can be increased when it is combined with Nefazodone.Approved, Withdrawn
NelfinavirThe serum concentration of Ivacaftor can be increased when it is combined with Nelfinavir.Approved
NetupitantThe serum concentration of Ivacaftor can be increased when it is combined with Netupitant.Approved
NevirapineThe serum concentration of Ivacaftor can be decreased when it is combined with Nevirapine.Approved
NicardipineThe serum concentration of Nicardipine can be increased when it is combined with Ivacaftor.Approved
NicotineThe serum concentration of Nicotine can be increased when it is combined with Ivacaftor.Approved
NifedipineThe serum concentration of Nifedipine can be increased when it is combined with Ivacaftor.Approved
NilotinibThe serum concentration of Ivacaftor can be increased when it is combined with Nilotinib.Approved, Investigational
NilvadipineThe serum concentration of Nilvadipine can be increased when it is combined with Ivacaftor.Approved
NimodipineThe serum concentration of Nimodipine can be increased when it is combined with Ivacaftor.Approved
NintedanibThe serum concentration of Nintedanib can be increased when it is combined with Ivacaftor.Approved
NisoldipineThe serum concentration of Nisoldipine can be increased when it is combined with Ivacaftor.Approved
NitrazepamThe serum concentration of Nitrazepam can be increased when it is combined with Ivacaftor.Approved
NitrendipineThe serum concentration of Nitrendipine can be increased when it is combined with Ivacaftor.Approved
NizatidineThe serum concentration of Nizatidine can be increased when it is combined with Ivacaftor.Approved
NorethisteroneThe serum concentration of Norethisterone can be increased when it is combined with Ivacaftor.Approved
NorgestrelThe serum concentration of Norgestrel can be increased when it is combined with Ivacaftor.Approved
NortriptylineThe serum concentration of Nortriptyline can be increased when it is combined with Ivacaftor.Approved
OlanzapineThe serum concentration of Olanzapine can be increased when it is combined with Ivacaftor.Approved, Investigational
OlaparibThe serum concentration of Ivacaftor can be increased when it is combined with Olaparib.Approved
OlopatadineThe serum concentration of Olopatadine can be increased when it is combined with Ivacaftor.Approved
OmbitasvirThe serum concentration of Ombitasvir can be increased when it is combined with Ivacaftor.Approved
OmeprazoleThe serum concentration of Omeprazole can be increased when it is combined with Ivacaftor.Approved, Investigational, Vet Approved
OndansetronThe serum concentration of Ondansetron can be increased when it is combined with Ivacaftor.Approved
OrphenadrineThe serum concentration of Orphenadrine can be increased when it is combined with Ivacaftor.Approved
OsimertinibThe serum concentration of Ivacaftor can be increased when it is combined with Osimertinib.Approved
OspemifeneThe serum concentration of Ospemifene can be increased when it is combined with Ivacaftor.Approved
OxazepamThe serum concentration of Oxazepam can be increased when it is combined with Ivacaftor.Approved
OxybutyninThe serum concentration of Oxybutynin can be increased when it is combined with Ivacaftor.Approved, Investigational
OxycodoneThe serum concentration of Oxycodone can be increased when it is combined with Ivacaftor.Approved, Illicit, Investigational
OxymorphoneThe serum concentration of Oxymorphone can be increased when it is combined with Ivacaftor.Approved, Investigational, Vet Approved
PaclitaxelThe serum concentration of Paclitaxel can be increased when it is combined with Ivacaftor.Approved, Vet Approved
PalbociclibThe serum concentration of Palbociclib can be increased when it is combined with Ivacaftor.Approved
PalonosetronThe serum concentration of Palonosetron can be increased when it is combined with Ivacaftor.Approved, Investigational
PanobinostatThe serum concentration of Panobinostat can be increased when it is combined with Ivacaftor.Approved, Investigational
PantoprazoleThe serum concentration of Pantoprazole can be increased when it is combined with Ivacaftor.Approved
ParamethadioneThe serum concentration of Paramethadione can be increased when it is combined with Ivacaftor.Approved
ParamethasoneThe serum concentration of Paramethasone can be increased when it is combined with Ivacaftor.Approved
ParecoxibThe serum concentration of Parecoxib can be increased when it is combined with Ivacaftor.Approved
ParicalcitolThe serum concentration of Paricalcitol can be increased when it is combined with Ivacaftor.Approved, Investigational
ParitaprevirThe serum concentration of Paritaprevir can be increased when it is combined with Ivacaftor.Approved
PazopanibThe serum concentration of Pazopanib can be increased when it is combined with Ivacaftor.Approved
PentamidineThe serum concentration of Pentamidine can be increased when it is combined with Ivacaftor.Approved
PentobarbitalThe serum concentration of Ivacaftor can be decreased when it is combined with Pentobarbital.Approved, Vet Approved
PerampanelThe serum concentration of Perampanel can be increased when it is combined with Ivacaftor.Approved
PergolideThe serum concentration of Pergolide can be increased when it is combined with Ivacaftor.Approved, Vet Approved, Withdrawn
PerhexilineThe serum concentration of Perhexiline can be increased when it is combined with Ivacaftor.Approved
PermethrinThe serum concentration of Permethrin can be increased when it is combined with Ivacaftor.Approved, Investigational
PerphenazineThe serum concentration of Perphenazine can be increased when it is combined with Ivacaftor.Approved
PethidineThe serum concentration of Pethidine can be increased when it is combined with Ivacaftor.Approved
PhenacetinThe serum concentration of Phenacetin can be increased when it is combined with Ivacaftor.Withdrawn
PhenobarbitalThe serum concentration of Ivacaftor can be decreased when it is combined with Phenobarbital.Approved
PhenoxybenzamineThe serum concentration of Phenoxybenzamine can be increased when it is combined with Ivacaftor.Approved
PhenprocoumonThe serum concentration of Phenprocoumon can be increased when it is combined with Ivacaftor.Approved
PhenytoinThe serum concentration of Ivacaftor can be decreased when it is combined with Phenytoin.Approved, Vet Approved
PilocarpineThe serum concentration of Pilocarpine can be increased when it is combined with Ivacaftor.Approved
PimecrolimusThe serum concentration of Pimecrolimus can be increased when it is combined with Ivacaftor.Approved, Investigational
PimozideThe serum concentration of Pimozide can be increased when it is combined with Ivacaftor.Approved
PinacidilThe serum concentration of Pinacidil can be increased when it is combined with Ivacaftor.Withdrawn
PioglitazoneThe serum concentration of Pioglitazone can be increased when it is combined with Ivacaftor.Approved, Investigational
PipotiazineThe serum concentration of Pipotiazine can be increased when it is combined with Ivacaftor.Approved
PitavastatinThe serum concentration of Pitavastatin can be increased when it is combined with Ivacaftor.Approved
PodofiloxThe serum concentration of Podofilox can be increased when it is combined with Ivacaftor.Approved
PomalidomideThe serum concentration of Pomalidomide can be increased when it is combined with Ivacaftor.Approved
PonatinibThe serum concentration of Ponatinib can be increased when it is combined with Ivacaftor.Approved
PosaconazoleThe serum concentration of Ivacaftor can be increased when it is combined with Posaconazole.Approved, Investigational, Vet Approved
PrasteroneThe serum concentration of Prasterone can be increased when it is combined with Ivacaftor.Approved, Nutraceutical
PrasugrelThe serum concentration of Prasugrel can be increased when it is combined with Ivacaftor.Approved
PravastatinThe serum concentration of Pravastatin can be increased when it is combined with Ivacaftor.Approved
PrazepamThe serum concentration of Prazepam can be increased when it is combined with Ivacaftor.Approved, Illicit
PraziquantelThe serum concentration of Praziquantel can be increased when it is combined with Ivacaftor.Approved, Vet Approved
PrazosinThe serum concentration of Prazosin can be increased when it is combined with Ivacaftor.Approved
PrednisoloneThe serum concentration of Prednisolone can be increased when it is combined with Ivacaftor.Approved, Vet Approved
PrednisoneThe serum concentration of Prednisone can be increased when it is combined with Ivacaftor.Approved, Vet Approved
PrimaquineThe serum concentration of Primaquine can be increased when it is combined with Ivacaftor.Approved
PrimidoneThe serum concentration of Ivacaftor can be decreased when it is combined with Primidone.Approved, Vet Approved
ProchlorperazineThe serum concentration of Prochlorperazine can be increased when it is combined with Ivacaftor.Approved, Vet Approved
ProgesteroneThe serum concentration of Progesterone can be increased when it is combined with Ivacaftor.Approved, Vet Approved
ProguanilThe serum concentration of Proguanil can be increased when it is combined with Ivacaftor.Approved
PromazineThe serum concentration of Promazine can be increased when it is combined with Ivacaftor.Approved, Vet Approved
PropafenoneThe serum concentration of Propafenone can be increased when it is combined with Ivacaftor.Approved
PropofolThe serum concentration of Propofol can be increased when it is combined with Ivacaftor.Approved, Investigational, Vet Approved
PropranololThe serum concentration of Propranolol can be increased when it is combined with Ivacaftor.Approved, Investigational
PrucaloprideThe serum concentration of Prucalopride can be increased when it is combined with Ivacaftor.Approved
PyrazinamideThe serum concentration of Pyrazinamide can be increased when it is combined with Ivacaftor.Approved
QuazepamThe serum concentration of Quazepam can be increased when it is combined with Ivacaftor.Approved, Illicit
QuetiapineThe serum concentration of Quetiapine can be increased when it is combined with Ivacaftor.Approved
QuinacrineThe serum concentration of Quinacrine can be increased when it is combined with Ivacaftor.Approved
QuinidineThe serum concentration of Quinidine can be increased when it is combined with Ivacaftor.Approved
QuinineThe serum concentration of Quinine can be increased when it is combined with Ivacaftor.Approved
RabeprazoleThe serum concentration of Rabeprazole can be increased when it is combined with Ivacaftor.Approved, Investigational
RaloxifeneThe serum concentration of Raloxifene can be increased when it is combined with Ivacaftor.Approved, Investigational
RamelteonThe serum concentration of Ramelteon can be increased when it is combined with Ivacaftor.Approved, Investigational
RanitidineThe serum concentration of Ranitidine can be increased when it is combined with Ivacaftor.Approved
RanolazineThe serum concentration of Ivacaftor can be increased when it is combined with Ranolazine.Approved, Investigational
ReboxetineThe serum concentration of Reboxetine can be increased when it is combined with Ivacaftor.Approved, Investigational
RegorafenibThe serum concentration of Regorafenib can be increased when it is combined with Ivacaftor.Approved
RepaglinideThe serum concentration of Repaglinide can be increased when it is combined with Ivacaftor.Approved, Investigational
ReserpineThe serum concentration of Reserpine can be increased when it is combined with Ivacaftor.Approved
RetapamulinThe serum concentration of Retapamulin can be increased when it is combined with Ivacaftor.Approved
RifabutinThe serum concentration of Ivacaftor can be decreased when it is combined with Rifabutin.Approved
RifampicinThe serum concentration of Ivacaftor can be decreased when it is combined with Rifampicin.Approved
RifapentineThe serum concentration of Ivacaftor can be decreased when it is combined with Rifapentine.Approved
RifaximinThe serum concentration of Rifaximin can be increased when it is combined with Ivacaftor.Approved, Investigational
RilpivirineThe serum concentration of Rilpivirine can be increased when it is combined with Ivacaftor.Approved
RimonabantThe serum concentration of Rimonabant can be increased when it is combined with Ivacaftor.Approved, Investigational
RiociguatThe serum concentration of Riociguat can be increased when it is combined with Ivacaftor.Approved
RisperidoneThe serum concentration of Risperidone can be increased when it is combined with Ivacaftor.Approved, Investigational
RitonavirThe serum concentration of Ivacaftor can be increased when it is combined with Ritonavir.Approved, Investigational
RivaroxabanThe serum concentration of Rivaroxaban can be increased when it is combined with Ivacaftor.Approved
RofecoxibThe serum concentration of Rofecoxib can be increased when it is combined with Ivacaftor.Investigational, Withdrawn
RolapitantThe serum concentration of Rolapitant can be increased when it is combined with Ivacaftor.Approved
RomidepsinThe serum concentration of Romidepsin can be increased when it is combined with Ivacaftor.Approved, Investigational
RopiniroleThe serum concentration of Ropinirole can be increased when it is combined with Ivacaftor.Approved, Investigational
RopivacaineThe serum concentration of Ropivacaine can be increased when it is combined with Ivacaftor.Approved
RosuvastatinThe serum concentration of Rosuvastatin can be increased when it is combined with Ivacaftor.Approved
RotigotineThe serum concentration of Rotigotine can be increased when it is combined with Ivacaftor.Approved
RoxithromycinThe serum concentration of Roxithromycin can be increased when it is combined with Ivacaftor.Approved, Withdrawn
RuxolitinibThe serum concentration of Ruxolitinib can be increased when it is combined with Ivacaftor.Approved
Salicylic acidThe serum concentration of Salicylic acid can be increased when it is combined with Ivacaftor.Approved, Vet Approved
SalmeterolThe serum concentration of Salmeterol can be increased when it is combined with Ivacaftor.Approved
SaquinavirThe serum concentration of Ivacaftor can be increased when it is combined with Saquinavir.Approved, Investigational
SaxagliptinThe serum concentration of Saxagliptin can be increased when it is combined with Ivacaftor.Approved
SelegilineThe serum concentration of Selegiline can be increased when it is combined with Ivacaftor.Approved, Investigational, Vet Approved
SelexipagThe serum concentration of Selexipag can be increased when it is combined with Ivacaftor.Approved
SeratrodastThe serum concentration of Seratrodast can be increased when it is combined with Ivacaftor.Approved, Investigational
SertindoleThe serum concentration of Sertindole can be increased when it is combined with Ivacaftor.Approved, Withdrawn
SertralineThe serum concentration of Sertraline can be increased when it is combined with Ivacaftor.Approved
SevofluraneThe serum concentration of Sevoflurane can be increased when it is combined with Ivacaftor.Approved, Vet Approved
SibutramineThe serum concentration of Sibutramine can be increased when it is combined with Ivacaftor.Approved, Illicit, Investigational, Withdrawn
SildenafilThe serum concentration of Ivacaftor can be increased when it is combined with Sildenafil.Approved, Investigational
SilodosinThe serum concentration of Silodosin can be increased when it is combined with Ivacaftor.Approved
SiltuximabThe serum concentration of Ivacaftor can be decreased when it is combined with Siltuximab.Approved
SimeprevirThe serum concentration of Simeprevir can be increased when it is combined with Ivacaftor.Approved
SimvastatinThe serum concentration of Simvastatin can be increased when it is combined with Ivacaftor.Approved
SirolimusThe serum concentration of Sirolimus can be increased when it is combined with Ivacaftor.Approved, Investigational
SitagliptinThe serum concentration of Sitagliptin can be increased when it is combined with Ivacaftor.Approved, Investigational
SofosbuvirThe serum concentration of Sofosbuvir can be increased when it is combined with Ivacaftor.Approved
SolifenacinThe serum concentration of Solifenacin can be increased when it is combined with Ivacaftor.Approved
SonidegibThe serum concentration of Sonidegib can be increased when it is combined with Ivacaftor.Approved, Investigational
SorafenibThe serum concentration of Sorafenib can be increased when it is combined with Ivacaftor.Approved, Investigational
SparfloxacinThe serum concentration of Sparfloxacin can be increased when it is combined with Ivacaftor.Approved
SphingosineThe serum concentration of Sphingosine can be increased when it is combined with Ivacaftor.Experimental
SpiramycinThe serum concentration of Spiramycin can be increased when it is combined with Ivacaftor.Approved
St. John's WortThe serum concentration of Ivacaftor can be decreased when it is combined with St. John's Wort.Nutraceutical
StiripentolThe serum concentration of Ivacaftor can be increased when it is combined with Stiripentol.Approved
SufentanilThe serum concentration of Sufentanil can be increased when it is combined with Ivacaftor.Approved, Investigational
SulfadiazineThe serum concentration of Sulfadiazine can be increased when it is combined with Ivacaftor.Approved, Vet Approved
SulfamethoxazoleThe serum concentration of Sulfamethoxazole can be increased when it is combined with Ivacaftor.Approved
SulfinpyrazoneThe serum concentration of Sulfinpyrazone can be increased when it is combined with Ivacaftor.Approved
SulfisoxazoleThe serum concentration of Ivacaftor can be increased when it is combined with Sulfisoxazole.Approved, Vet Approved
SunitinibThe serum concentration of Sunitinib can be increased when it is combined with Ivacaftor.Approved, Investigational
Synthetic Conjugated Estrogens, AThe serum concentration of Synthetic Conjugated Estrogens, A can be increased when it is combined with Ivacaftor.Approved
Synthetic Conjugated Estrogens, BThe serum concentration of Synthetic Conjugated Estrogens, B can be increased when it is combined with Ivacaftor.Approved
TacrolimusThe serum concentration of Tacrolimus can be increased when it is combined with Ivacaftor.Approved, Investigational
TadalafilThe serum concentration of Tadalafil can be increased when it is combined with Ivacaftor.Approved, Investigational
TamoxifenThe serum concentration of Tamoxifen can be increased when it is combined with Ivacaftor.Approved
TamsulosinThe serum concentration of Tamsulosin can be increased when it is combined with Ivacaftor.Approved, Investigational
TasosartanThe serum concentration of Tasosartan can be increased when it is combined with Ivacaftor.Approved
Taurochenodeoxycholic acidThe serum concentration of Taurochenodeoxycholic acid can be increased when it is combined with Ivacaftor.Experimental
Taurocholic AcidThe serum concentration of Taurocholic Acid can be increased when it is combined with Ivacaftor.Experimental
Technetium Tc-99m sestamibiThe serum concentration of Technetium Tc-99m sestamibi can be increased when it is combined with Ivacaftor.Approved
TelaprevirThe serum concentration of Ivacaftor can be increased when it is combined with Telaprevir.Approved
TelithromycinThe serum concentration of Ivacaftor can be increased when it is combined with Telithromycin.Approved
TemazepamThe serum concentration of Temazepam can be increased when it is combined with Ivacaftor.Approved
TemsirolimusThe serum concentration of Temsirolimus can be increased when it is combined with Ivacaftor.Approved
TeniposideThe serum concentration of Teniposide can be increased when it is combined with Ivacaftor.Approved
TerbinafineThe serum concentration of Terbinafine can be increased when it is combined with Ivacaftor.Approved, Investigational, Vet Approved
TerfenadineThe serum concentration of Terfenadine can be increased when it is combined with Ivacaftor.Withdrawn
TesmilifeneThe serum concentration of Tesmilifene can be increased when it is combined with Ivacaftor.Investigational
TestosteroneThe serum concentration of Testosterone can be increased when it is combined with Ivacaftor.Approved, Investigational
TetracyclineThe serum concentration of Tetracycline can be increased when it is combined with Ivacaftor.Approved, Vet Approved
TheophyllineThe serum concentration of Theophylline can be increased when it is combined with Ivacaftor.Approved
ThiotepaThe serum concentration of Thiotepa can be increased when it is combined with Ivacaftor.Approved
TiagabineThe serum concentration of Tiagabine can be increased when it is combined with Ivacaftor.Approved
TicagrelorThe serum concentration of Ticagrelor can be increased when it is combined with Ivacaftor.Approved
TiclopidineThe serum concentration of Ivacaftor can be increased when it is combined with Ticlopidine.Approved
TimololThe serum concentration of Timolol can be increased when it is combined with Ivacaftor.Approved
TinidazoleThe serum concentration of Tinidazole can be increased when it is combined with Ivacaftor.Approved, Investigational
TiotropiumThe serum concentration of Tiotropium can be increased when it is combined with Ivacaftor.Approved
TipranavirThe serum concentration of Tipranavir can be increased when it is combined with Ivacaftor.Approved, Investigational
TocilizumabThe serum concentration of Ivacaftor can be decreased when it is combined with Tocilizumab.Approved
TofacitinibThe serum concentration of Tofacitinib can be increased when it is combined with Ivacaftor.Approved, Investigational
TolterodineThe serum concentration of Tolterodine can be increased when it is combined with Ivacaftor.Approved, Investigational
TolvaptanThe serum concentration of Tolvaptan can be increased when it is combined with Ivacaftor.Approved
TopotecanThe serum concentration of Topotecan can be increased when it is combined with Ivacaftor.Approved, Investigational
ToremifeneThe serum concentration of Toremifene can be increased when it is combined with Ivacaftor.Approved, Investigational
TrabectedinThe serum concentration of Trabectedin can be increased when it is combined with Ivacaftor.Approved, Investigational
TramadolThe serum concentration of Tramadol can be increased when it is combined with Ivacaftor.Approved, Investigational
Trastuzumab emtansineThe serum concentration of Trastuzumab emtansine can be increased when it is combined with Ivacaftor.Approved
TrazodoneThe serum concentration of Trazodone can be increased when it is combined with Ivacaftor.Approved, Investigational
TretinoinThe serum concentration of Tretinoin can be increased when it is combined with Ivacaftor.Approved, Investigational, Nutraceutical
TriamcinoloneThe serum concentration of Triamcinolone can be increased when it is combined with Ivacaftor.Approved, Vet Approved
TriazolamThe serum concentration of Triazolam can be increased when it is combined with Ivacaftor.Approved
TrimethadioneThe serum concentration of Trimethadione can be increased when it is combined with Ivacaftor.Approved
TrimethoprimThe serum concentration of Trimethoprim can be increased when it is combined with Ivacaftor.Approved, Vet Approved
TrimipramineThe serum concentration of Trimipramine can be increased when it is combined with Ivacaftor.Approved
TroglitazoneThe serum concentration of Troglitazone can be increased when it is combined with Ivacaftor.Withdrawn
TroleandomycinThe serum concentration of Troleandomycin can be increased when it is combined with Ivacaftor.Approved
UdenafilThe serum concentration of Udenafil can be increased when it is combined with Ivacaftor.Approved, Investigational
UlipristalThe serum concentration of Ulipristal can be increased when it is combined with Ivacaftor.Approved
UmeclidiniumThe serum concentration of Umeclidinium can be increased when it is combined with Ivacaftor.Approved
ValdecoxibThe serum concentration of Valdecoxib can be increased when it is combined with Ivacaftor.Investigational, Withdrawn
VandetanibThe serum concentration of Vandetanib can be increased when it is combined with Ivacaftor.Approved
VanoxerineThe serum concentration of Vanoxerine can be increased when it is combined with Ivacaftor.Investigational
VardenafilThe serum concentration of Vardenafil can be increased when it is combined with Ivacaftor.Approved
VecuroniumThe serum concentration of Vecuronium can be increased when it is combined with Ivacaftor.Approved
VemurafenibThe serum concentration of Vemurafenib can be increased when it is combined with Ivacaftor.Approved
VenetoclaxThe serum concentration of Venetoclax can be increased when it is combined with Ivacaftor.Approved
VenlafaxineThe serum concentration of Ivacaftor can be increased when it is combined with Venlafaxine.Approved
VerapamilThe serum concentration of Ivacaftor can be increased when it is combined with Verapamil.Approved
VicrivirocThe serum concentration of Vicriviroc can be increased when it is combined with Ivacaftor.Investigational
VilanterolThe serum concentration of Vilanterol can be increased when it is combined with Ivacaftor.Approved
VilazodoneThe serum concentration of Vilazodone can be increased when it is combined with Ivacaftor.Approved
VinblastineThe serum concentration of Vinblastine can be increased when it is combined with Ivacaftor.Approved
VincristineThe serum concentration of Vincristine can be increased when it is combined with Ivacaftor.Approved, Investigational
VindesineThe serum concentration of Vindesine can be increased when it is combined with Ivacaftor.Approved
VinorelbineThe serum concentration of Vinorelbine can be increased when it is combined with Ivacaftor.Approved, Investigational
VismodegibThe serum concentration of Vismodegib can be increased when it is combined with Ivacaftor.Approved
VoriconazoleThe serum concentration of Ivacaftor can be increased when it is combined with Voriconazole.Approved, Investigational
VortioxetineThe serum concentration of Vortioxetine can be increased when it is combined with Ivacaftor.Approved
WarfarinThe serum concentration of Warfarin can be increased when it is combined with Ivacaftor.Approved
YohimbineThe serum concentration of Yohimbine can be increased when it is combined with Ivacaftor.Approved, Vet Approved
ZafirlukastThe serum concentration of Zafirlukast can be increased when it is combined with Ivacaftor.Approved, Investigational
ZalcitabineThe serum concentration of Zalcitabine can be increased when it is combined with Ivacaftor.Approved
ZaleplonThe serum concentration of Zaleplon can be increased when it is combined with Ivacaftor.Approved, Illicit, Investigational
ZidovudineThe serum concentration of Zidovudine can be increased when it is combined with Ivacaftor.Approved
ZileutonThe serum concentration of Zileuton can be increased when it is combined with Ivacaftor.Approved, Investigational, Withdrawn
ZiprasidoneThe serum concentration of Ivacaftor can be increased when it is combined with Ziprasidone.Approved
ZolpidemThe serum concentration of Zolpidem can be increased when it is combined with Ivacaftor.Approved
ZomepiracThe serum concentration of Zomepirac can be increased when it is combined with Ivacaftor.Withdrawn
ZonisamideThe serum concentration of Zonisamide can be increased when it is combined with Ivacaftor.Approved, Investigational
ZopicloneThe serum concentration of Zopiclone can be increased when it is combined with Ivacaftor.Approved
Food Interactions
  • Exposure increases 2- to 4- fold when given with a high fat meal. It is recommended that ivacaftor be given this way.
References
Synthesis ReferenceNot Available
General References
  1. Accurso FJ, Rowe SM, Clancy JP, Boyle MP, Dunitz JM, Durie PR, Sagel SD, Hornick DB, Konstan MW, Donaldson SH, Moss RB, Pilewski JM, Rubenstein RC, Uluer AZ, Aitken ML, Freedman SD, Rose LM, Mayer-Hamblett N, Dong Q, Zha J, Stone AJ, Olson ER, Ordonez CL, Campbell PW, Ashlock MA, Ramsey BW: Effect of VX-770 in persons with cystic fibrosis and the G551D-CFTR mutation. N Engl J Med. 2010 Nov 18;363(21):1991-2003. doi: 10.1056/NEJMoa0909825. [PubMed:21083385 ]
  2. Ramsey BW, Davies J, McElvaney NG, Tullis E, Bell SC, Drevinek P, Griese M, McKone EF, Wainwright CE, Konstan MW, Moss R, Ratjen F, Sermet-Gaudelus I, Rowe SM, Dong Q, Rodriguez S, Yen K, Ordonez C, Elborn JS: A CFTR potentiator in patients with cystic fibrosis and the G551D mutation. N Engl J Med. 2011 Nov 3;365(18):1663-72. doi: 10.1056/NEJMoa1105185. [PubMed:22047557 ]
External Links
ATC CodesR07AX30R07AX02
AHFS Codes
  • 48:92
PDB EntriesNot Available
FDA labelDownload (239 KB)
MSDSDownload (353 KB)
ADMET
Predicted ADMET features
PropertyValueProbability
Human Intestinal Absorption+0.9577
Blood Brain Barrier+0.6561
Caco-2 permeable-0.5608
P-glycoprotein substrateNon-substrate0.5474
P-glycoprotein inhibitor INon-inhibitor0.7677
P-glycoprotein inhibitor IINon-inhibitor0.7609
Renal organic cation transporterNon-inhibitor0.945
CYP450 2C9 substrateNon-substrate0.7374
CYP450 2D6 substrateNon-substrate0.8362
CYP450 3A4 substrateSubstrate0.5686
CYP450 1A2 substrateInhibitor0.5438
CYP450 2C9 inhibitorInhibitor0.6456
CYP450 2D6 inhibitorNon-inhibitor0.9469
CYP450 2C19 inhibitorNon-inhibitor0.6422
CYP450 3A4 inhibitorNon-inhibitor0.8404
CYP450 inhibitory promiscuityHigh CYP Inhibitory Promiscuity0.5791
Ames testNon AMES toxic0.8394
CarcinogenicityNon-carcinogens0.8149
BiodegradationNot ready biodegradable1.0
Rat acute toxicity2.2868 LD50, mol/kg Not applicable
hERG inhibition (predictor I)Weak inhibitor0.9961
hERG inhibition (predictor II)Non-inhibitor0.819
ADMET data is predicted using admetSAR, a free tool for evaluating chemical ADMET properties. (23092397 )
Pharmacoeconomics
ManufacturersNot Available
PackagersNot Available
Dosage forms
FormRouteStrength
GranuleOral50 mg/1
GranuleOral50 mg
GranuleOral75 mg/1
GranuleOral75 mg
TabletOral150 mg
Tablet, film coatedOral150 mg/1
TabletOral
Tablet, film coatedOral
PricesNot Available
Patents
Patent NumberPediatric ExtensionApprovedExpires (estimated)
US7495103 No2007-05-202027-05-20Us
US8324242 No2007-04-182027-04-18Us
US8354427 No2006-07-062026-07-06Us
US8410274 No2006-12-282026-12-28Us
US8507534 No2010-09-202030-09-20Us
US8653103 No2008-12-042028-12-04Us
US8716338 No2006-11-082026-11-08Us
US8741933 No2006-11-082026-11-08Us
US8754224 No2006-12-282026-12-28Us
US8846718 No2008-12-042028-12-04Us
US8883206 No2013-02-272033-02-27Us
US8993600 No2010-12-112030-12-11Us
US9216969 No2006-11-082026-11-08Us
Properties
StateSolid
Experimental Properties
PropertyValueSource
water solubilityInsoluble (<0.05 µg/mL)FDA label
Predicted Properties
PropertyValueSource
Water Solubility0.002 mg/mLALOGPS
logP5ALOGPS
logP5.76ChemAxon
logS-5.3ALOGPS
pKa (Strongest Acidic)6.57ChemAxon
pKa (Strongest Basic)-0.95ChemAxon
Physiological Charge-1ChemAxon
Hydrogen Acceptor Count4ChemAxon
Hydrogen Donor Count3ChemAxon
Polar Surface Area78.43 Å2ChemAxon
Rotatable Bond Count4ChemAxon
Refractivity118.68 m3·mol-1ChemAxon
Polarizability43.04 Å3ChemAxon
Number of Rings3ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleYesChemAxon
Spectra
Mass Spec (NIST)Not Available
Spectra
Spectrum TypeDescriptionSplash Key
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, PositiveNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, PositiveNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, PositiveNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, NegativeNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, NegativeNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, NegativeNot Available
Taxonomy
DescriptionThis compound belongs to the class of organic compounds known as quinoline-3-carboxamides. These are quinolines in which the quinoline ring system is substituted by one carboxamide group at the 3-position.
KingdomOrganic compounds
Super ClassOrganoheterocyclic compounds
ClassQuinolines and derivatives
Sub ClassQuinoline carboxamides
Direct ParentQuinoline-3-carboxamides
Alternative Parents
Substituents
  • Quinoline-3-carboxamide
  • Dihydroquinolone
  • N-arylamide
  • Dihydroquinoline
  • Pyridine carboxylic acid or derivatives
  • Phenylpropane
  • Phenol
  • Benzenoid
  • Pyridine
  • Monocyclic benzene moiety
  • Heteroaromatic compound
  • Vinylogous amide
  • Secondary carboxylic acid amide
  • Carboxamide group
  • Azacycle
  • Carboxylic acid derivative
  • Hydrocarbon derivative
  • Organooxygen compound
  • Organonitrogen compound
  • Carbonyl group
  • Aromatic heteropolycyclic compound
Molecular FrameworkAromatic heteropolycyclic compounds
External Descriptors

Targets

Kind
Protein
Organism
Human
Pharmacological action
yes
Actions
potentiator
General Function:
Pdz domain binding
Specific Function:
Involved in the transport of chloride ions. May regulate bicarbonate secretion and salvage in epithelial cells by regulating the SLC4A7 transporter. Can inhibit the chloride channel activity of ANO1. Plays a role in the chloride and bicarbonate homeostasis during sperm epididymal maturation and capacitation.
Gene Name:
CFTR
Uniprot ID:
P13569
Molecular Weight:
168139.895 Da
References
  1. Yu H, Burton B, Huang CJ, Worley J, Cao D, Johnson JP Jr, Urrutia A, Joubran J, Seepersaud S, Sussky K, Hoffman BJ, Van Goor F: Ivacaftor potentiation of multiple CFTR channels with gating mutations. J Cyst Fibros. 2012 May;11(3):237-45. doi: 10.1016/j.jcf.2011.12.005. Epub 2012 Jan 30. [PubMed:22293084 ]

Enzymes

Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrateinhibitor
General Function:
Vitamin d3 25-hydroxylase activity
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It performs a variety of oxidation reactions (e.g. caffeine 8-oxidation, omeprazole sulphoxidation, midazolam 1'-hydroxylation and midazolam 4-hydroxylation) of structurally unrelated compounds, including steroids, fatty acids, and xenobiot...
Gene Name:
CYP3A4
Uniprot ID:
P08684
Molecular Weight:
57342.67 Da

Carriers

Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrate
General Function:
Toxic substance binding
Specific Function:
Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc.
Gene Name:
ALB
Uniprot ID:
P02768
Molecular Weight:
69365.94 Da
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrate
General Function:
Not Available
Specific Function:
Functions as transport protein in the blood stream. Binds various ligands in the interior of its beta-barrel domain. Also binds synthetic drugs and influences their distribution and availability in the body. Appears to function in modulating the activity of the immune system during the acute-phase reaction.
Gene Name:
ORM1
Uniprot ID:
P02763
Molecular Weight:
23511.38 Da

Transporters

Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Xenobiotic-transporting atpase activity
Specific Function:
Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells.
Gene Name:
ABCB1
Uniprot ID:
P08183
Molecular Weight:
141477.255 Da
Comments
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Drug created on February 24, 2012 11:15 / Updated on December 06, 2016 02:50