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Identification
NameRifapentine
Accession NumberDB01201  (APRD01217)
TypeSmall Molecule
GroupsApproved
DescriptionRifapentine is an antibiotic drug used in the treatment of tuberculosis. It inhibits DNA-dependent RNA polymerase activity in susceptible cells. Specifically, it interacts with bacterial RNA polymerase but does not inhibit the mammalian enzyme.
Structure
Thumb
Synonyms
3-(((4-Cyclopentyl-1-piperazinyl)imino)methyl)rifamycin
Cyclopentylrifampicin
Priftin (tn)
External Identifiers Not Available
Approved Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
PriftinTablet, film coated150 mg/1OralSanofi Aventis U.S. Llc1998-06-22Not applicableUs
Approved Generic Prescription ProductsNot Available
Approved Over the Counter ProductsNot Available
Unapproved/Other Products Not Available
International BrandsNot Available
Brand mixturesNot Available
SaltsNot Available
Categories
UNIIXJM390A33U
CAS number61379-65-5
WeightAverage: 877.0307
Monoisotopic: 876.452073532
Chemical FormulaC47H64N4O12
InChI KeyWDZCUPBHRAEYDL-GZAUEHORSA-N
InChI
InChI=1S/C47H64N4O12/c1-24-13-12-14-25(2)46(59)49-37-32(23-48-51-20-18-50(19-21-51)31-15-10-11-16-31)41(56)34-35(42(37)57)40(55)29(6)44-36(34)45(58)47(8,63-44)61-22-17-33(60-9)26(3)43(62-30(7)52)28(5)39(54)27(4)38(24)53/h12-14,17,22-24,26-28,31,33,38-39,43,53-57H,10-11,15-16,18-21H2,1-9H3,(H,49,59)/b13-12+,22-17+,25-14-,48-23+/t24-,26+,27+,28+,33-,38-,39+,43+,47-/m0/s1
IUPAC Name
(7S,9E,11S,12R,13S,14R,15R,16R,17S,18S,19E,21Z)-26-[(1E)-[(4-cyclopentylpiperazin-1-yl)imino]methyl]-2,15,17,27,29-pentahydroxy-11-methoxy-3,7,12,14,16,18,22-heptamethyl-6,23-dioxo-8,30-dioxa-24-azatetracyclo[23.3.1.1⁴,⁷.0⁵,²⁸]triaconta-1(28),2,4,9,19,21,25(29),26-octaen-13-yl acetate
SMILES
CO[[email protected]]1\C=C\O[C@@]2(C)OC3=C(C2=O)C2=C(C(O)=C3C)C(O)=C(NC(=O)\C(C)=C/C=C/[[email protected]](C)[[email protected]](O)[C@@H](C)[C@@H](O)[C@@H](C)[[email protected]](OC(C)=O)[C@@H]1C)C(\C=N\N1CCN(CC1)C1CCCC1)=C2O
Pharmacology
IndicationFor the treatment of pulmonary tuberculosis.
Structured Indications
PharmacodynamicsRifapentine is an antibiotic that inhibits DNA-dependent RNA polymerase activity in susceptible cells. Specifically, it interacts with bacterial RNA polymerase but does not inhibit the mammalian enzyme. It is bactericidal and has a very broad spectrum of activity against most gram-positive and gram-negative organisms (including Pseudomonas aeruginosa) and specifically Mycobacterium tuberculosis. Because of rapid emergence of resistant bacteria, use is restricted to treatment of mycobacterial infections and a few other indications. Rifampin is well absorbed when taken orally and is distributed widely in body tissues and fluids, including the CSF. It is metabolized in the liver and eliminated in bile and, to a much lesser extent, in urine, but dose adjustments are unnecessary with renal insufficiency.
Mechanism of actionRifapentine has shown higher bacteriostatic and bactericidal activities especially against intracellular bacteria growing in human monocyte-derived macrophages. Rifapentine inhibits DNA-dependent RNA polymerase in susceptible strains of M. tuberculosis. Rifapentine acts via the inhibition of DNA-dependent RNA polymerase, leading to a suppression of RNA synthesis and cell death.
TargetKindPharmacological actionActionsOrganismUniProt ID
DNA-directed RNA polymerase subunit beta'Proteinyes
inhibitor
Mycobacterium tuberculosisP0A674 details
Related Articles
AbsorptionRapidly and well absorbed from the gastrointestinal tract.
Volume of distribution
  • 70.2 ± 9.1 L
Protein binding97.7% (bound to plasma proteins)
Metabolism

Hepatic

Route of eliminationFollowing a single 600 mg oral dose of radiolabeled rifapentine to healthy volunteers (n=4), 87% of the total 14C rifapentine was recovered in the urine (17%) and feces (70%).
Half lifeNot Available
Clearance
  • Apparent Oral cl=2.51 +/- 0.14 L/h [Male tuberculosis patients who received 600 mg rifapentine in combination with isoniazid, pyrazinamide and ethambutol]
  • Apparent Oral cl=1.69 +/- 0.41 L/h [Female tuberculosis patients who received 600 mg rifapentine in combination with isoniazid, pyrazinamide and ethambutol]
ToxicityNot Available
Affected organisms
  • Mycobacterium tuberculosis
  • Mycobacterium
PathwaysNot Available
SNP Mediated EffectsNot Available
SNP Mediated Adverse Drug ReactionsNot Available
Interactions
Drug Interactions
DrugInteractionDrug group
16-BromoepiandrosteroneThe serum concentration of 16-Bromoepiandrosterone can be decreased when it is combined with Rifapentine.Investigational
19-norandrostenedioneThe serum concentration of 19-norandrostenedione can be decreased when it is combined with Rifapentine.Experimental, Illicit
2-HYDROXY-1,4-NAPHTHOQUINONEThe serum concentration of Rifapentine can be increased when it is combined with 2-HYDROXY-1,4-NAPHTHOQUINONE.Experimental
2-mercaptobenzothiazoleThe serum concentration of Rifapentine can be increased when it is combined with 2-mercaptobenzothiazole.Vet Approved
4-AndrostenedioneThe serum concentration of 4-Androstenedione can be decreased when it is combined with Rifapentine.Experimental, Illicit
5-androstenedioneThe serum concentration of 5-androstenedione can be decreased when it is combined with Rifapentine.Experimental, Illicit
AbirateroneThe serum concentration of Abiraterone can be decreased when it is combined with Rifapentine.Approved
AcebutololThe serum concentration of Acebutolol can be decreased when it is combined with Rifapentine.Approved
AceclofenacThe metabolism of Aceclofenac can be increased when combined with Rifapentine.Approved
AcenocoumarolThe metabolism of Acenocoumarol can be increased when combined with Rifapentine.Approved
AcetaminophenThe metabolism of Acetaminophen can be increased when combined with Rifapentine.Approved
Acetylsalicylic acidThe metabolism of Acetylsalicylic acid can be increased when combined with Rifapentine.Approved, Vet Approved
AdinazolamThe metabolism of Adinazolam can be increased when combined with Rifapentine.Approved
AlbendazoleThe metabolism of Albendazole can be increased when combined with Rifapentine.Approved, Vet Approved
AlclometasoneThe metabolism of Alclometasone can be increased when combined with Rifapentine.Approved
AldosteroneThe serum concentration of Aldosterone can be decreased when it is combined with Rifapentine.Experimental
AlfentanilThe serum concentration of Alfentanil can be decreased when it is combined with Rifapentine.Approved, Illicit
AlfuzosinThe metabolism of Alfuzosin can be increased when combined with Rifapentine.Approved, Investigational
AliskirenThe metabolism of Aliskiren can be increased when combined with Rifapentine.Approved, Investigational
AllylestrenolThe metabolism of Allylestrenol can be increased when combined with Rifapentine.Approved
AlmotriptanThe metabolism of Almotriptan can be increased when combined with Rifapentine.Approved, Investigational
AlogliptinThe metabolism of Alogliptin can be increased when combined with Rifapentine.Approved
AlosetronThe metabolism of Alosetron can be increased when combined with Rifapentine.Approved, Withdrawn
AlprazolamThe metabolism of Alprazolam can be increased when combined with Rifapentine.Approved, Illicit, Investigational
AlprenololThe serum concentration of Alprenolol can be decreased when it is combined with Rifapentine.Approved, Withdrawn
AmbrisentanThe metabolism of Ambrisentan can be increased when combined with Rifapentine.Approved, Investigational
AmbroxolThe metabolism of Ambroxol can be increased when combined with Rifapentine.Approved
AmcinonideThe serum concentration of Amcinonide can be decreased when it is combined with Rifapentine.Approved
AminophenazoneThe metabolism of Aminophenazone can be increased when combined with Rifapentine.Approved, Withdrawn
AminophyllineThe metabolism of Aminophylline can be increased when combined with Rifapentine.Approved
AmiodaroneThe metabolism of Amiodarone can be increased when combined with Rifapentine.Approved, Investigational
AmitriptylineThe metabolism of Amitriptyline can be increased when combined with Rifapentine.Approved
AmlodipineThe metabolism of Amlodipine can be increased when combined with Rifapentine.Approved
AmobarbitalThe metabolism of Amobarbital can be increased when combined with Rifapentine.Approved, Illicit
AmodiaquineThe metabolism of Amodiaquine can be increased when combined with Rifapentine.Approved
AmorolfineThe serum concentration of Rifapentine can be increased when it is combined with Amorolfine.Approved
Amphotericin BThe serum concentration of Rifapentine can be increased when it is combined with Amphotericin B.Approved, Investigational
AmprenavirThe metabolism of Amprenavir can be increased when combined with Rifapentine.Approved
AmrinoneThe serum concentration of Amrinone can be decreased when it is combined with Rifapentine.Approved
AN2690The serum concentration of Rifapentine can be increased when it is combined with AN2690.Investigational
AnecortaveThe serum concentration of Anecortave can be decreased when it is combined with Rifapentine.Investigational
AnidulafunginThe serum concentration of Rifapentine can be increased when it is combined with Anidulafungin.Approved, Investigational
AntipyrineThe metabolism of Antipyrine can be increased when combined with Rifapentine.Approved
Aop200704The serum concentration of Aop200704 can be decreased when it is combined with Rifapentine.Investigational
ApixabanThe serum concentration of Apixaban can be decreased when it is combined with Rifapentine.Approved
ApremilastThe serum concentration of Apremilast can be decreased when it is combined with Rifapentine.Approved, Investigational
AprepitantThe metabolism of Aprepitant can be increased when combined with Rifapentine.Approved, Investigational
Arachidonic AcidThe metabolism of Arachidonic Acid can be increased when combined with Rifapentine.Experimental
ArformoterolThe metabolism of Arformoterol can be increased when combined with Rifapentine.Approved, Investigational
ArgatrobanThe metabolism of Argatroban can be increased when combined with Rifapentine.Approved, Investigational
AripiprazoleThe serum concentration of Aripiprazole can be decreased when it is combined with Rifapentine.Approved, Investigational
ArotinololThe serum concentration of Arotinolol can be decreased when it is combined with Rifapentine.Approved
ArtemetherThe serum concentration of the active metabolites of Artemether can be reduced when Artemether is used in combination with Rifapentine resulting in a loss in efficacy.Approved
AsenapineThe metabolism of Asenapine can be increased when combined with Rifapentine.Approved
AstemizoleThe metabolism of Astemizole can be increased when combined with Rifapentine.Approved, Withdrawn
AtazanavirThe metabolism of Atazanavir can be increased when combined with Rifapentine.Approved, Investigational
AtenololThe serum concentration of Atenolol can be decreased when it is combined with Rifapentine.Approved
AtorvastatinThe metabolism of Atorvastatin can be increased when combined with Rifapentine.Approved
AtovaquoneThe serum concentration of Atovaquone can be decreased when it is combined with Rifapentine.Approved
AvanafilThe metabolism of Avanafil can be increased when combined with Rifapentine.Approved
AxitinibThe serum concentration of Axitinib can be decreased when it is combined with Rifapentine.Approved, Investigational
AzelastineThe metabolism of Azelastine can be increased when combined with Rifapentine.Approved
AzelnidipineThe serum concentration of Azelnidipine can be decreased when it is combined with Rifapentine.Approved
AzimilideThe serum concentration of Azimilide can be decreased when it is combined with Rifapentine.Investigational
AzithromycinThe metabolism of Azithromycin can be increased when combined with Rifapentine.Approved
Bafilomycin A1The serum concentration of Rifapentine can be increased when it is combined with Bafilomycin A1.Experimental
BanoxantroneThe metabolism of Banoxantrone can be increased when combined with Rifapentine.Investigational
BarbexacloneThe metabolism of Barbexaclone can be increased when combined with Rifapentine.Experimental
BarbitalThe metabolism of Barbital can be increased when combined with Rifapentine.Illicit
BarnidipineThe serum concentration of Barnidipine can be decreased when it is combined with Rifapentine.Approved
BcgThe therapeutic efficacy of Bcg can be decreased when used in combination with Rifapentine.Investigational
BeclomethasoneThe serum concentration of Beclomethasone can be decreased when it is combined with Rifapentine.Investigational
Beclomethasone dipropionateThe serum concentration of Beclomethasone dipropionate can be decreased when it is combined with Rifapentine.Approved, Investigational
BedaquilineThe serum concentration of Bedaquiline can be decreased when it is combined with Rifapentine.Approved
BefunololThe serum concentration of Befunolol can be decreased when it is combined with Rifapentine.Experimental
BenidipineThe serum concentration of Benidipine can be decreased when it is combined with Rifapentine.Approved
Benzoic AcidThe serum concentration of Rifapentine can be increased when it is combined with Benzoic Acid.Approved
BenzphetamineThe metabolism of Benzphetamine can be increased when combined with Rifapentine.Approved, Illicit
Benzyl alcoholThe metabolism of Benzyl alcohol can be increased when combined with Rifapentine.Approved
BepridilThe serum concentration of Bepridil can be decreased when it is combined with Rifapentine.Approved, Withdrawn
BeraprostThe metabolism of Beraprost can be increased when combined with Rifapentine.Investigational
BetamethasoneThe serum concentration of Betamethasone can be decreased when it is combined with Rifapentine.Approved, Vet Approved
BetaxololThe serum concentration of Betaxolol can be decreased when it is combined with Rifapentine.Approved
BevantololThe serum concentration of Bevantolol can be decreased when it is combined with Rifapentine.Approved
BexaroteneThe metabolism of Bexarotene can be increased when combined with Rifapentine.Approved, Investigational
BezafibrateThe metabolism of Bezafibrate can be increased when combined with Rifapentine.Approved
BicalutamideThe metabolism of Bicalutamide can be increased when combined with Rifapentine.Approved
BifonazoleThe serum concentration of Rifapentine can be increased when it is combined with Bifonazole.Approved
BisoprololThe metabolism of Bisoprolol can be increased when combined with Rifapentine.Approved
BoceprevirThe serum concentration of Boceprevir can be decreased when it is combined with Rifapentine.Approved
BopindololThe serum concentration of Bopindolol can be decreased when it is combined with Rifapentine.Approved
BortezomibThe serum concentration of Bortezomib can be decreased when it is combined with Rifapentine.Approved, Investigational
BosentanThe metabolism of Bosentan can be increased when combined with Rifapentine.Approved, Investigational
BosutinibThe serum concentration of Bosutinib can be decreased when it is combined with Rifapentine.Approved
Brentuximab vedotinThe serum concentration of Brentuximab vedotin can be decreased when it is combined with Rifapentine.Approved
BrexpiprazoleThe serum concentration of Brexpiprazole can be decreased when it is combined with Rifapentine.Approved
BrinzolamideThe metabolism of Brinzolamide can be increased when combined with Rifapentine.Approved
BromazepamThe metabolism of Bromazepam can be increased when combined with Rifapentine.Approved, Illicit
BromocriptineThe metabolism of Bromocriptine can be increased when combined with Rifapentine.Approved, Investigational
BrompheniramineThe metabolism of Brompheniramine can be increased when combined with Rifapentine.Approved
BucindololThe serum concentration of Bucindolol can be decreased when it is combined with Rifapentine.Investigational
BudesonideThe metabolism of Budesonide can be increased when combined with Rifapentine.Approved
BufuralolThe serum concentration of Bufuralol can be decreased when it is combined with Rifapentine.Experimental, Investigational
BupivacaineThe metabolism of Bupivacaine can be increased when combined with Rifapentine.Approved, Investigational
BupranololThe serum concentration of Bupranolol can be decreased when it is combined with Rifapentine.Approved
BuprenorphineThe metabolism of Buprenorphine can be increased when combined with Rifapentine.Approved, Illicit, Investigational, Vet Approved
BupropionThe metabolism of Bupropion can be increased when combined with Rifapentine.Approved
BuspironeThe serum concentration of Buspirone can be decreased when it is combined with Rifapentine.Approved, Investigational
BusulfanThe metabolism of Busulfan can be increased when combined with Rifapentine.Approved, Investigational
ButenafineThe serum concentration of Rifapentine can be increased when it is combined with Butenafine.Approved
ButoconazoleThe serum concentration of Rifapentine can be increased when it is combined with Butoconazole.Approved
CabazitaxelThe metabolism of Cabazitaxel can be increased when combined with Rifapentine.Approved
CabergolineThe metabolism of Cabergoline can be increased when combined with Rifapentine.Approved
CabozantinibThe serum concentration of Cabozantinib can be decreased when it is combined with Rifapentine.Approved
CaffeineThe metabolism of Caffeine can be increased when combined with Rifapentine.Approved
CaiThe serum concentration of Cai can be decreased when it is combined with Rifapentine.Investigational
CalcitriolThe metabolism of Calcitriol can be increased when combined with Rifapentine.Approved, Nutraceutical
CanagliflozinThe metabolism of Canagliflozin can be increased when combined with Rifapentine.Approved
CandesartanThe metabolism of Candesartan can be increased when combined with Rifapentine.Approved
CandicidinThe serum concentration of Rifapentine can be increased when it is combined with Candicidin.Withdrawn
CannabidiolThe serum concentration of Cannabidiol can be decreased when it is combined with Rifapentine.Approved, Investigational
CarbamazepineThe metabolism of Carbamazepine can be increased when combined with Rifapentine.Approved, Investigational
CarbinoxamineThe metabolism of Carbinoxamine can be increased when combined with Rifapentine.Approved
CariprazineThe metabolism of Cariprazine can be increased when combined with Rifapentine.Approved
CarteololThe serum concentration of Carteolol can be decreased when it is combined with Rifapentine.Approved
CarvedilolThe metabolism of Carvedilol can be increased when combined with Rifapentine.Approved, Investigational
CaspofunginThe serum concentration of Rifapentine can be increased when it is combined with Caspofungin.Approved
CelecoxibThe metabolism of Celecoxib can be increased when combined with Rifapentine.Approved, Investigational
CeliprololThe metabolism of Celiprolol can be increased when combined with Rifapentine.Approved, Investigational
CephalexinThe metabolism of Cephalexin can be increased when combined with Rifapentine.Approved, Vet Approved
CeritinibThe serum concentration of Ceritinib can be decreased when it is combined with Rifapentine.Approved
CerivastatinThe metabolism of Cerivastatin can be increased when combined with Rifapentine.Withdrawn
CeruleninThe serum concentration of Rifapentine can be increased when it is combined with Cerulenin.Approved
CevimelineThe metabolism of Cevimeline can be increased when combined with Rifapentine.Approved
Chenodeoxycholic acidThe metabolism of Chenodeoxycholic acid can be increased when combined with Rifapentine.Approved
ChlordiazepoxideThe metabolism of Chlordiazepoxide can be increased when combined with Rifapentine.Approved, Illicit
ChloroquineThe metabolism of Chloroquine can be increased when combined with Rifapentine.Approved, Vet Approved
ChlorotrianiseneThe serum concentration of Chlorotrianisene can be decreased when it is combined with Rifapentine.Withdrawn
ChloroxineThe serum concentration of Rifapentine can be increased when it is combined with Chloroxine.Approved
ChlorphenamineThe metabolism of Chlorphenamine can be increased when combined with Rifapentine.Approved
ChlorpromazineThe metabolism of Chlorpromazine can be increased when combined with Rifapentine.Approved, Vet Approved
ChlorpropamideThe metabolism of Chlorpropamide can be increased when combined with Rifapentine.Approved
ChlorzoxazoneThe metabolism of Chlorzoxazone can be increased when combined with Rifapentine.Approved
CholecalciferolThe metabolism of Cholecalciferol can be increased when combined with Rifapentine.Approved, Nutraceutical
CiclesonideThe metabolism of Ciclesonide can be increased when combined with Rifapentine.Approved, Investigational
CiclopiroxThe serum concentration of Rifapentine can be increased when it is combined with Ciclopirox.Approved, Investigational
CilnidipineThe serum concentration of Cilnidipine can be decreased when it is combined with Rifapentine.Approved
CilostazolThe metabolism of Cilostazol can be increased when combined with Rifapentine.Approved
CinacalcetThe metabolism of Cinacalcet can be increased when combined with Rifapentine.Approved
CinnarizineThe metabolism of Cinnarizine can be increased when combined with Rifapentine.Approved
CisaprideThe metabolism of Cisapride can be increased when combined with Rifapentine.Approved, Investigational, Withdrawn
CitalopramThe metabolism of Citalopram can be increased when combined with Rifapentine.Approved
ClarithromycinThe serum concentration of the active metabolites of Clarithromycin can be increased when Clarithromycin is used in combination with Rifapentine.Approved
ClevidipineThe serum concentration of Clevidipine can be decreased when it is combined with Rifapentine.Approved
ClindamycinThe metabolism of Clindamycin can be increased when combined with Rifapentine.Approved, Vet Approved
ClobazamThe metabolism of Clobazam can be increased when combined with Rifapentine.Approved, Illicit
ClobetasolThe serum concentration of Clobetasol can be decreased when it is combined with Rifapentine.Investigational
Clobetasol propionateThe serum concentration of Clobetasol propionate can be decreased when it is combined with Rifapentine.Approved
ClocortoloneThe serum concentration of Clocortolone can be decreased when it is combined with Rifapentine.Approved
ClofazimineThe metabolism of Clofazimine can be increased when combined with Rifapentine.Approved, Investigational
ClofibrateThe metabolism of Clofibrate can be increased when combined with Rifapentine.Approved
clomethiazoleThe metabolism of clomethiazole can be increased when combined with Rifapentine.Investigational
ClomipramineThe metabolism of Clomipramine can be increased when combined with Rifapentine.Approved, Vet Approved
ClonazepamThe metabolism of Clonazepam can be increased when combined with Rifapentine.Approved, Illicit
ClonidineThe metabolism of Clonidine can be increased when combined with Rifapentine.Approved
ClopidogrelThe risk or severity of adverse effects can be increased when Rifapentine is combined with Clopidogrel.Approved, Nutraceutical
ClorazepateThe metabolism of Clorazepate can be increased when combined with Rifapentine.Approved, Illicit
ClotiazepamThe metabolism of Clotiazepam can be increased when combined with Rifapentine.Approved, Illicit
ClotrimazoleThe serum concentration of Rifapentine can be increased when it is combined with Clotrimazole.Approved, Vet Approved
ClozapineThe serum concentration of Clozapine can be decreased when it is combined with Rifapentine.Approved
CobicistatThe serum concentration of Cobicistat can be decreased when it is combined with Rifapentine.Approved
CobimetinibThe serum concentration of Cobimetinib can be decreased when it is combined with Rifapentine.Approved
CocaineThe metabolism of Cocaine can be increased when combined with Rifapentine.Approved, Illicit
CodeineThe metabolism of Codeine can be increased when combined with Rifapentine.Approved, Illicit
Coenzyme Q10The serum concentration of Coenzyme Q10 can be decreased when it is combined with Rifapentine.Experimental
ColchicineThe metabolism of Colchicine can be increased when combined with Rifapentine.Approved
ConivaptanThe metabolism of Conivaptan can be increased when combined with Rifapentine.Approved, Investigational
Conjugated Equine EstrogensThe metabolism of Conjugated Equine Estrogens can be increased when combined with Rifapentine.Approved
CordycepinThe serum concentration of Rifapentine can be increased when it is combined with Cordycepin.Investigational
Cortisone acetateThe metabolism of Cortisone acetate can be increased when combined with Rifapentine.Approved
CrizotinibThe serum concentration of Crizotinib can be decreased when it is combined with Rifapentine.Approved
CyclobenzaprineThe metabolism of Cyclobenzaprine can be increased when combined with Rifapentine.Approved
CyclophosphamideThe metabolism of Cyclophosphamide can be increased when combined with Rifapentine.Approved, Investigational
CyclosporineThe metabolism of Cyclosporine can be increased when combined with Rifapentine.Approved, Investigational, Vet Approved
CytarabineThe metabolism of Cytarabine can be increased when combined with Rifapentine.Approved, Investigational
DabrafenibThe metabolism of Dabrafenib can be increased when combined with Rifapentine.Approved
DaclatasvirThe serum concentration of Daclatasvir can be decreased when it is combined with Rifapentine.Approved
DantroleneThe metabolism of Dantrolene can be increased when combined with Rifapentine.Approved
DapagliflozinThe metabolism of Dapagliflozin can be increased when combined with Rifapentine.Approved
DapsoneThe metabolism of Dapsone can be increased when combined with Rifapentine.Approved, Investigational
DarifenacinThe metabolism of Darifenacin can be increased when combined with Rifapentine.Approved, Investigational
DarodipineThe serum concentration of Darodipine can be decreased when it is combined with Rifapentine.Experimental
DarunavirThe serum concentration of Darunavir can be decreased when it is combined with Rifapentine.Approved
DasabuvirThe serum concentration of Dasabuvir can be decreased when it is combined with Rifapentine.Approved
DasatinibThe serum concentration of Dasatinib can be decreased when it is combined with Rifapentine.Approved, Investigational
DaunorubicinThe metabolism of Daunorubicin can be increased when combined with Rifapentine.Approved
Decanoic AcidThe serum concentration of Rifapentine can be increased when it is combined with Decanoic Acid.Experimental
dehydroepiandrosterone sulfateThe serum concentration of dehydroepiandrosterone sulfate can be decreased when it is combined with Rifapentine.Investigational
DelavirdineThe metabolism of Delavirdine can be increased when combined with Rifapentine.Approved
DesogestrelThe serum concentration of Desogestrel can be decreased when it is combined with Rifapentine.Approved
DesoximetasoneThe serum concentration of Desoximetasone can be decreased when it is combined with Rifapentine.Approved
Desoxycorticosterone acetateThe serum concentration of Desoxycorticosterone acetate can be decreased when it is combined with Rifapentine.Approved
Desoxycorticosterone PivalateThe serum concentration of Desoxycorticosterone Pivalate can be decreased when it is combined with Rifapentine.Experimental, Vet Approved
DesvenlafaxineThe metabolism of Desvenlafaxine can be increased when combined with Rifapentine.Approved
DexamethasoneThe serum concentration of Dexamethasone can be decreased when it is combined with Rifapentine.Approved, Investigational, Vet Approved
DexamethasoneThe metabolism of Dexamethasone can be increased when combined with Rifapentine.Approved, Investigational, Vet Approved
Dexamethasone isonicotinateThe serum concentration of Dexamethasone isonicotinate can be decreased when it is combined with Rifapentine.Vet Approved
DextromethorphanThe metabolism of Dextromethorphan can be increased when combined with Rifapentine.Approved
DextropropoxypheneThe metabolism of Dextropropoxyphene can be increased when combined with Rifapentine.Approved, Illicit, Withdrawn
DiazepamThe metabolism of Diazepam can be increased when combined with Rifapentine.Approved, Illicit, Vet Approved
DiclofenacThe metabolism of Diclofenac can be increased when combined with Rifapentine.Approved, Vet Approved
DiclofenacThe serum concentration of Diclofenac can be decreased when it is combined with Rifapentine.Approved, Vet Approved
DicoumarolThe metabolism of Dicoumarol can be increased when combined with Rifapentine.Approved
DienestrolThe serum concentration of Dienestrol can be decreased when it is combined with Rifapentine.Approved
DienogestThe serum concentration of Dienogest can be decreased when it is combined with Rifapentine.Approved
DiethylstilbestrolThe serum concentration of Diethylstilbestrol can be decreased when it is combined with Rifapentine.Approved
DiflorasoneThe serum concentration of Diflorasone can be decreased when it is combined with Rifapentine.Approved
DifluocortoloneThe serum concentration of Difluocortolone can be decreased when it is combined with Rifapentine.Approved
DifluprednateThe serum concentration of Difluprednate can be decreased when it is combined with Rifapentine.Approved
DigitoxinThe metabolism of Digitoxin can be increased when combined with Rifapentine.Approved
DigoxinThe metabolism of Digoxin can be increased when combined with Rifapentine.Approved
DihydrocodeineThe metabolism of Dihydrocodeine can be increased when combined with Rifapentine.Approved, Illicit
DihydroergotamineThe metabolism of Dihydroergotamine can be increased when combined with Rifapentine.Approved
DiltiazemThe metabolism of Diltiazem can be increased when combined with Rifapentine.Approved
DiphenhydramineThe metabolism of Diphenhydramine can be increased when combined with Rifapentine.Approved
DisopyramideThe metabolism of Disopyramide can be increased when combined with Rifapentine.Approved
DisulfiramThe metabolism of Disulfiram can be increased when combined with Rifapentine.Approved
DocetaxelThe metabolism of Docetaxel can be increased when combined with Rifapentine.Approved, Investigational
DofetilideThe metabolism of Dofetilide can be increased when combined with Rifapentine.Approved
DolasetronThe metabolism of Dolasetron can be increased when combined with Rifapentine.Approved
DomperidoneThe metabolism of Domperidone can be increased when combined with Rifapentine.Approved, Investigational, Vet Approved
DonepezilThe metabolism of Donepezil can be increased when combined with Rifapentine.Approved
DopamineThe metabolism of Dopamine can be increased when combined with Rifapentine.Approved
DorzolamideThe metabolism of Dorzolamide can be increased when combined with Rifapentine.Approved
DotarizineThe serum concentration of Dotarizine can be decreased when it is combined with Rifapentine.Investigational
DoxepinThe metabolism of Doxepin can be increased when combined with Rifapentine.Approved
DoxorubicinThe serum concentration of Doxorubicin can be decreased when it is combined with Rifapentine.Approved, Investigational
DoxorubicinThe metabolism of Doxorubicin can be increased when combined with Rifapentine.Approved, Investigational
DronabinolThe serum concentration of Dronabinol can be decreased when it is combined with Rifapentine.Approved, Illicit
DronedaroneThe serum concentration of Dronedarone can be decreased when it is combined with Rifapentine.Approved
DrospirenoneThe serum concentration of Drospirenone can be decreased when it is combined with Rifapentine.Approved
DutasterideThe metabolism of Dutasteride can be increased when combined with Rifapentine.Approved, Investigational
EconazoleThe serum concentration of Rifapentine can be increased when it is combined with Econazole.Approved
EfavirenzThe metabolism of Efavirenz can be increased when combined with Rifapentine.Approved, Investigational
EfinaconazoleThe serum concentration of Rifapentine can be increased when it is combined with Efinaconazole.Approved
EfonidipineThe serum concentration of Efonidipine can be decreased when it is combined with Rifapentine.Approved
EletriptanThe metabolism of Eletriptan can be increased when combined with Rifapentine.Approved, Investigational
EliglustatThe serum concentration of Eliglustat can be decreased when it is combined with Rifapentine.Approved
EltrombopagThe metabolism of Eltrombopag can be increased when combined with Rifapentine.Approved
ElvitegravirThe serum concentration of Elvitegravir can be decreased when it is combined with Rifapentine.Approved
EnalaprilThe metabolism of Enalapril can be increased when combined with Rifapentine.Approved, Vet Approved
EnzalutamideThe serum concentration of Enzalutamide can be decreased when it is combined with Rifapentine.Approved
EperisoneThe serum concentration of Eperisone can be decreased when it is combined with Rifapentine.Approved, Investigational
EpinastineThe metabolism of Epinastine can be increased when combined with Rifapentine.Approved, Investigational
EplerenoneThe metabolism of Eplerenone can be increased when combined with Rifapentine.Approved
EpoprostenolThe metabolism of Epoprostenol can be increased when combined with Rifapentine.Approved
EquileninThe serum concentration of Equilenin can be decreased when it is combined with Rifapentine.Experimental
EquilinThe serum concentration of Equilin can be decreased when it is combined with Rifapentine.Approved
ErgocalciferolThe metabolism of Ergocalciferol can be increased when combined with Rifapentine.Approved, Nutraceutical
Ergoloid mesylateThe metabolism of Ergoloid mesylate can be increased when combined with Rifapentine.Approved
ErgonovineThe metabolism of Ergonovine can be increased when combined with Rifapentine.Approved
ErgotamineThe metabolism of Ergotamine can be increased when combined with Rifapentine.Approved
ErlotinibThe serum concentration of Erlotinib can be decreased when it is combined with Rifapentine.Approved, Investigational
ErythromycinThe metabolism of Erythromycin can be increased when combined with Rifapentine.Approved, Vet Approved
EscitalopramThe metabolism of Escitalopram can be increased when combined with Rifapentine.Approved, Investigational
EsmololThe serum concentration of Esmolol can be decreased when it is combined with Rifapentine.Approved
EsomeprazoleThe metabolism of Esomeprazole can be increased when combined with Rifapentine.Approved, Investigational
EstazolamThe metabolism of Estazolam can be increased when combined with Rifapentine.Approved, Illicit
EstradiolThe metabolism of Estradiol can be increased when combined with Rifapentine.Approved, Investigational, Vet Approved
Estradiol valerate/DienogestThe metabolism of Estradiol valerate/Dienogest can be increased when combined with Rifapentine.Approved
EstramustineThe metabolism of Estramustine can be increased when combined with Rifapentine.Approved
Estrogens, esterifiedThe serum concentration of Estrogens, esterified can be decreased when it is combined with Rifapentine.Approved
EstroneThe metabolism of Estrone can be increased when combined with Rifapentine.Approved
Estrone sulfateThe metabolism of Estrone sulfate can be increased when combined with Rifapentine.Approved
EszopicloneThe metabolism of Eszopiclone can be increased when combined with Rifapentine.Approved
EthanolThe metabolism of Ethanol can be increased when combined with Rifapentine.Approved
Ethinyl EstradiolThe metabolism of Ethinyl Estradiol can be increased when combined with Rifapentine.Approved
EthosuximideThe metabolism of Ethosuximide can be increased when combined with Rifapentine.Approved
Ethyl biscoumacetateThe metabolism of Ethyl biscoumacetate can be increased when combined with Rifapentine.Withdrawn
EthylmorphineThe metabolism of Ethylmorphine can be increased when combined with Rifapentine.Approved, Illicit
Ethynodiol diacetateThe serum concentration of Ethynodiol diacetate can be decreased when it is combined with Rifapentine.Approved
EtodolacThe metabolism of Etodolac can be increased when combined with Rifapentine.Approved, Investigational, Vet Approved
EtonogestrelThe metabolism of Etonogestrel can be increased when combined with Rifapentine.Approved, Investigational
EtoposideThe serum concentration of Etoposide can be decreased when it is combined with Rifapentine.Approved
EtoricoxibThe metabolism of Etoricoxib can be increased when combined with Rifapentine.Approved, Investigational
EtravirineThe serum concentration of Etravirine can be decreased when it is combined with Rifapentine.Approved
EverolimusThe serum concentration of Everolimus can be decreased when it is combined with Rifapentine.Approved
ExemestaneThe serum concentration of Exemestane can be decreased when it is combined with Rifapentine.Approved, Investigational
FamciclovirThe metabolism of Famciclovir can be increased when combined with Rifapentine.Approved
FelbamateThe metabolism of Felbamate can be increased when combined with Rifapentine.Approved
FelodipineThe metabolism of Felodipine can be increased when combined with Rifapentine.Approved, Investigational
FendilineThe serum concentration of Fendiline can be decreased when it is combined with Rifapentine.Withdrawn
FenofibrateThe metabolism of Fenofibrate can be increased when combined with Rifapentine.Approved
FentanylThe serum concentration of Fentanyl can be decreased when it is combined with Rifapentine.Approved, Illicit, Investigational, Vet Approved
FesoterodineThe metabolism of Fesoterodine can be increased when combined with Rifapentine.Approved
FinasterideThe metabolism of Finasteride can be increased when combined with Rifapentine.Approved
FingolimodThe metabolism of Fingolimod can be increased when combined with Rifapentine.Approved, Investigational
FlibanserinThe serum concentration of Flibanserin can be decreased when it is combined with Rifapentine.Approved
fluasteroneThe serum concentration of fluasterone can be decreased when it is combined with Rifapentine.Investigational
FluconazoleThe serum concentration of Rifapentine can be increased when it is combined with Fluconazole.Approved
FlucytosineThe serum concentration of Rifapentine can be increased when it is combined with Flucytosine.Approved
FludrocortisoneThe serum concentration of Fludrocortisone can be decreased when it is combined with Rifapentine.Approved
FluindioneThe metabolism of Fluindione can be increased when combined with Rifapentine.Investigational
FlumethasoneThe serum concentration of Flumethasone can be decreased when it is combined with Rifapentine.Approved, Vet Approved
FlunarizineThe metabolism of Flunarizine can be increased when combined with Rifapentine.Approved
FlunisolideThe metabolism of Flunisolide can be increased when combined with Rifapentine.Approved, Investigational
FlunitrazepamThe metabolism of Flunitrazepam can be increased when combined with Rifapentine.Approved, Illicit
Fluocinolone AcetonideThe serum concentration of Fluocinolone Acetonide can be decreased when it is combined with Rifapentine.Approved, Investigational, Vet Approved
FluocinonideThe serum concentration of Fluocinonide can be decreased when it is combined with Rifapentine.Approved, Investigational
FluocortoloneThe serum concentration of Fluocortolone can be decreased when it is combined with Rifapentine.Approved, Withdrawn
FluorometholoneThe metabolism of Fluorometholone can be increased when combined with Rifapentine.Approved
FluorouracilThe metabolism of Fluorouracil can be increased when combined with Rifapentine.Approved
FluoxetineThe metabolism of Fluoxetine can be increased when combined with Rifapentine.Approved, Vet Approved
FluprednideneThe serum concentration of Fluprednidene can be decreased when it is combined with Rifapentine.Approved, Withdrawn
FluprednisoloneThe serum concentration of Fluprednisolone can be decreased when it is combined with Rifapentine.Approved
FlurandrenolideThe serum concentration of Flurandrenolide can be decreased when it is combined with Rifapentine.Approved
FlurazepamThe metabolism of Flurazepam can be increased when combined with Rifapentine.Approved, Illicit
FlurbiprofenThe metabolism of Flurbiprofen can be increased when combined with Rifapentine.Approved, Investigational
FlutamideThe metabolism of Flutamide can be increased when combined with Rifapentine.Approved
Fluticasone furoateThe metabolism of Fluticasone furoate can be increased when combined with Rifapentine.Approved
Fluticasone PropionateThe metabolism of Fluticasone Propionate can be increased when combined with Rifapentine.Approved
FluvastatinThe metabolism of Fluvastatin can be increased when combined with Rifapentine.Approved
FormestaneThe serum concentration of Formestane can be decreased when it is combined with Rifapentine.Approved, Investigational, Withdrawn
FormoterolThe metabolism of Formoterol can be increased when combined with Rifapentine.Approved, Investigational
FosamprenavirThe metabolism of Fosamprenavir can be increased when combined with Rifapentine.Approved
FosphenytoinThe metabolism of Fosphenytoin can be increased when combined with Rifapentine.Approved
FulvestrantThe metabolism of Fulvestrant can be increased when combined with Rifapentine.Approved, Investigational
GabapentinThe serum concentration of Gabapentin can be decreased when it is combined with Rifapentine.Approved, Investigational
GalantamineThe metabolism of Galantamine can be increased when combined with Rifapentine.Approved
GallopamilThe serum concentration of Gallopamil can be decreased when it is combined with Rifapentine.Investigational
GavestinelThe metabolism of Gavestinel can be increased when combined with Rifapentine.Investigational
GefitinibThe serum concentration of Gefitinib can be decreased when it is combined with Rifapentine.Approved, Investigational
GemfibrozilThe metabolism of Gemfibrozil can be increased when combined with Rifapentine.Approved
GestodeneThe serum concentration of Gestodene can be decreased when it is combined with Rifapentine.Approved
GliclazideThe metabolism of Gliclazide can be increased when combined with Rifapentine.Approved
GlimepirideThe metabolism of Glimepiride can be increased when combined with Rifapentine.Approved
GlipizideThe metabolism of Glipizide can be increased when combined with Rifapentine.Approved
GlyburideThe metabolism of Glyburide can be increased when combined with Rifapentine.Approved
GlyphosateThe serum concentration of Rifapentine can be increased when it is combined with Glyphosate.Experimental
GranisetronThe metabolism of Granisetron can be increased when combined with Rifapentine.Approved, Investigational
GrepafloxacinThe metabolism of Grepafloxacin can be increased when combined with Rifapentine.Withdrawn
GriseofulvinThe serum concentration of Rifapentine can be increased when it is combined with Griseofulvin.Approved, Vet Approved
GuanfacineThe serum concentration of Guanfacine can be decreased when it is combined with Rifapentine.Approved, Investigational
HalofantrineThe metabolism of Halofantrine can be increased when combined with Rifapentine.Approved
HaloperidolThe metabolism of Haloperidol can be increased when combined with Rifapentine.Approved
HaloproginThe serum concentration of Rifapentine can be increased when it is combined with Haloprogin.Approved, Withdrawn
HalothaneThe metabolism of Halothane can be increased when combined with Rifapentine.Approved, Vet Approved
HE3286The serum concentration of HE3286 can be decreased when it is combined with Rifapentine.Investigational
HexestrolThe serum concentration of Hexestrol can be decreased when it is combined with Rifapentine.Withdrawn
HexetidineThe serum concentration of Rifapentine can be increased when it is combined with Hexetidine.Approved
HexobarbitalThe metabolism of Hexobarbital can be increased when combined with Rifapentine.Approved
Histamine PhosphateThe metabolism of Histamine Phosphate can be increased when combined with Rifapentine.Approved
HydrocodoneThe serum concentration of Hydrocodone can be decreased when it is combined with Rifapentine.Approved, Illicit
HydrocortisoneThe metabolism of Hydrocortisone can be increased when combined with Rifapentine.Approved, Vet Approved
HydrocortisoneThe serum concentration of Hydrocortisone can be decreased when it is combined with Rifapentine.Approved, Vet Approved
HydromorphoneThe metabolism of Hydromorphone can be increased when combined with Rifapentine.Approved, Illicit
Hydroxyprogesterone caproateThe metabolism of Hydroxyprogesterone caproate can be increased when combined with Rifapentine.Approved
IbrutinibThe serum concentration of Ibrutinib can be decreased when it is combined with Rifapentine.Approved
IbuprofenThe metabolism of Ibuprofen can be increased when combined with Rifapentine.Approved
IdarubicinThe metabolism of Idarubicin can be increased when combined with Rifapentine.Approved
IdelalisibThe serum concentration of Idelalisib can be decreased when it is combined with Rifapentine.Approved
IfosfamideThe serum concentration of the active metabolites of Ifosfamide can be increased when Ifosfamide is used in combination with Rifapentine.Approved
IloperidoneThe metabolism of Iloperidone can be increased when combined with Rifapentine.Approved
ImatinibThe serum concentration of Imatinib can be decreased when it is combined with Rifapentine.Approved
ImipramineThe metabolism of Imipramine can be increased when combined with Rifapentine.Approved
ImiquimodThe metabolism of Imiquimod can be increased when combined with Rifapentine.Approved, Investigational
IndacaterolThe metabolism of Indacaterol can be increased when combined with Rifapentine.Approved
IndapamideThe metabolism of Indapamide can be increased when combined with Rifapentine.Approved
IndenololThe serum concentration of Indenolol can be decreased when it is combined with Rifapentine.Withdrawn
IndinavirThe metabolism of Indinavir can be increased when combined with Rifapentine.Approved
indisulamThe metabolism of indisulam can be increased when combined with Rifapentine.Investigational
IndomethacinThe metabolism of Indomethacin can be increased when combined with Rifapentine.Approved, Investigational
Ipratropium bromideThe metabolism of Ipratropium bromide can be increased when combined with Rifapentine.Approved
IrbesartanThe metabolism of Irbesartan can be increased when combined with Rifapentine.Approved, Investigational
IrinotecanThe serum concentration of the active metabolites of Irinotecan can be reduced when Irinotecan is used in combination with Rifapentine resulting in a loss in efficacy.Approved, Investigational
IsavuconazoniumThe serum concentration of the active metabolites of Isavuconazonium can be reduced when Isavuconazonium is used in combination with Rifapentine resulting in a loss in efficacy.Approved, Investigational
IsoconazoleThe serum concentration of Rifapentine can be increased when it is combined with Isoconazole.Approved
IsoniazidRifapentine may increase the hepatotoxic activities of Isoniazid.Approved
Isosorbide DinitrateThe metabolism of Isosorbide Dinitrate can be increased when combined with Rifapentine.Approved
Isosorbide MononitrateThe metabolism of Isosorbide Mononitrate can be increased when combined with Rifapentine.Approved
IsradipineThe metabolism of Isradipine can be increased when combined with Rifapentine.Approved
IstaroximeThe serum concentration of Istaroxime can be decreased when it is combined with Rifapentine.Investigational
ItraconazoleThe serum concentration of Itraconazole can be decreased when it is combined with Rifapentine.Approved, Investigational
IvabradineThe serum concentration of Ivabradine can be decreased when it is combined with Rifapentine.Approved
IvacaftorThe serum concentration of Ivacaftor can be decreased when it is combined with Rifapentine.Approved
IvermectinThe metabolism of Ivermectin can be increased when combined with Rifapentine.Approved, Vet Approved
IxabepiloneThe serum concentration of Ixabepilone can be decreased when it is combined with Rifapentine.Approved, Investigational
IxazomibThe serum concentration of Ixazomib can be decreased when it is combined with Rifapentine.Approved
KetamineThe metabolism of Ketamine can be increased when combined with Rifapentine.Approved, Vet Approved
KetazolamThe metabolism of Ketazolam can be increased when combined with Rifapentine.Approved
KetobemidoneThe metabolism of Ketobemidone can be increased when combined with Rifapentine.Approved
KetoconazoleThe metabolism of Ketoconazole can be increased when combined with Rifapentine.Approved, Investigational
KetoprofenThe metabolism of Ketoprofen can be increased when combined with Rifapentine.Approved, Vet Approved
LabetalolThe serum concentration of Labetalol can be decreased when it is combined with Rifapentine.Approved
LacidipineThe serum concentration of Lacidipine can be decreased when it is combined with Rifapentine.Approved
LamotrigineThe serum concentration of Lamotrigine can be decreased when it is combined with Rifapentine.Approved, Investigational
LansoprazoleThe metabolism of Lansoprazole can be increased when combined with Rifapentine.Approved, Investigational
LapatinibThe serum concentration of Lapatinib can be decreased when it is combined with Rifapentine.Approved, Investigational
LaquinimodThe metabolism of Laquinimod can be increased when combined with Rifapentine.Investigational
LedipasvirThe serum concentration of Ledipasvir can be decreased when it is combined with Rifapentine.Approved
LeflunomideThe metabolism of Leflunomide can be increased when combined with Rifapentine.Approved, Investigational
LenvatinibThe metabolism of Lenvatinib can be increased when combined with Rifapentine.Approved
LercanidipineThe metabolism of Lercanidipine can be increased when combined with Rifapentine.Approved, Investigational
LesinuradThe metabolism of Lesinurad can be increased when combined with Rifapentine.Approved
LetrozoleThe metabolism of Letrozole can be increased when combined with Rifapentine.Approved, Investigational
LevobunololThe serum concentration of Levobunolol can be decreased when it is combined with Rifapentine.Approved
LevobupivacaineThe metabolism of Levobupivacaine can be increased when combined with Rifapentine.Approved
LevocetirizineThe metabolism of Levocetirizine can be increased when combined with Rifapentine.Approved
Levomethadyl AcetateThe metabolism of Levomethadyl Acetate can be increased when combined with Rifapentine.Approved
LevomilnacipranThe metabolism of Levomilnacipran can be increased when combined with Rifapentine.Approved
LevonorgestrelThe metabolism of Levonorgestrel can be increased when combined with Rifapentine.Approved, Investigational
LevothyroxineThe metabolism of Levothyroxine can be increased when combined with Rifapentine.Approved
LicofeloneThe metabolism of Licofelone can be increased when combined with Rifapentine.Investigational
LidocaineThe metabolism of Lidocaine can be increased when combined with Rifapentine.Approved, Vet Approved
LinagliptinThe serum concentration of Linagliptin can be decreased when it is combined with Rifapentine.Approved
LisurideThe metabolism of Lisuride can be increased when combined with Rifapentine.Approved
LomitapideThe metabolism of Lomitapide can be increased when combined with Rifapentine.Approved
LoperamideThe metabolism of Loperamide can be increased when combined with Rifapentine.Approved
LopinavirThe metabolism of Lopinavir can be increased when combined with Rifapentine.Approved
LoratadineThe metabolism of Loratadine can be increased when combined with Rifapentine.Approved
LorcaserinThe metabolism of Lorcaserin can be increased when combined with Rifapentine.Approved
LornoxicamThe metabolism of Lornoxicam can be increased when combined with Rifapentine.Approved
LosartanThe metabolism of Losartan can be increased when combined with Rifapentine.Approved
LovastatinThe metabolism of Lovastatin can be increased when combined with Rifapentine.Approved, Investigational
LumefantrineThe serum concentration of Lumefantrine can be decreased when it is combined with Rifapentine.Approved
LumiracoxibThe metabolism of Lumiracoxib can be increased when combined with Rifapentine.Approved, Investigational
LurasidoneThe serum concentration of Lurasidone can be decreased when it is combined with Rifapentine.Approved
LynestrenolThe serum concentration of Lynestrenol can be decreased when it is combined with Rifapentine.Investigational
MacitentanThe serum concentration of Macitentan can be decreased when it is combined with Rifapentine.Approved
Magnesium SulfateThe serum concentration of Magnesium Sulfate can be decreased when it is combined with Rifapentine.Approved, Vet Approved
ManidipineThe serum concentration of Manidipine can be decreased when it is combined with Rifapentine.Approved
MaravirocThe serum concentration of Maraviroc can be decreased when it is combined with Rifapentine.Approved, Investigational
ME-609The serum concentration of ME-609 can be decreased when it is combined with Rifapentine.Investigational
MebendazoleThe metabolism of Mebendazole can be increased when combined with Rifapentine.Approved, Vet Approved
Medroxyprogesterone acetateThe metabolism of Medroxyprogesterone acetate can be increased when combined with Rifapentine.Approved, Investigational
MedrysoneThe serum concentration of Medrysone can be decreased when it is combined with Rifapentine.Approved
Mefenamic acidThe metabolism of Mefenamic acid can be increased when combined with Rifapentine.Approved
MefloquineThe metabolism of Mefloquine can be increased when combined with Rifapentine.Approved
MelatoninThe metabolism of Melatonin can be increased when combined with Rifapentine.Approved, Nutraceutical, Vet Approved
MelengestrolThe serum concentration of Melengestrol can be decreased when it is combined with Rifapentine.Vet Approved
MeloxicamThe metabolism of Meloxicam can be increased when combined with Rifapentine.Approved, Vet Approved
MephenytoinThe metabolism of Mephenytoin can be increased when combined with Rifapentine.Investigational, Withdrawn
MestranolThe metabolism of Mestranol can be increased when combined with Rifapentine.Approved
MethadoneThe serum concentration of Methadone can be decreased when it is combined with Rifapentine.Approved
MethallenestrilThe serum concentration of Methallenestril can be decreased when it is combined with Rifapentine.Experimental
MethaqualoneThe metabolism of Methaqualone can be increased when combined with Rifapentine.Illicit, Withdrawn
MethohexitalThe metabolism of Methohexital can be increased when combined with Rifapentine.Approved
MethoxsalenThe metabolism of Methoxsalen can be increased when combined with Rifapentine.Approved
MethoxyfluraneThe metabolism of Methoxyflurane can be increased when combined with Rifapentine.Approved, Vet Approved
MethylphenobarbitalThe metabolism of Methylphenobarbital can be increased when combined with Rifapentine.Approved
MethylprednisoloneThe serum concentration of Methylprednisolone can be decreased when it is combined with Rifapentine.Approved, Vet Approved
MethyltestosteroneThe metabolism of Methyltestosterone can be increased when combined with Rifapentine.Approved
MetipranololThe serum concentration of Metipranolol can be decreased when it is combined with Rifapentine.Approved
MetoprololThe serum concentration of Metoprolol can be decreased when it is combined with Rifapentine.Approved, Investigational
MetronidazoleThe metabolism of Metronidazole can be increased when combined with Rifapentine.Approved
MevastatinThe serum concentration of Mevastatin can be decreased when it is combined with Rifapentine.Experimental
MexiletineThe metabolism of Mexiletine can be increased when combined with Rifapentine.Approved
MianserinThe metabolism of Mianserin can be increased when combined with Rifapentine.Approved
MibefradilThe metabolism of Mibefradil can be increased when combined with Rifapentine.Withdrawn
MicafunginThe serum concentration of Rifapentine can be increased when it is combined with Micafungin.Approved, Investigational
MiconazoleThe metabolism of Miconazole can be increased when combined with Rifapentine.Approved, Investigational, Vet Approved
MidazolamThe metabolism of Midazolam can be increased when combined with Rifapentine.Approved, Illicit
MifepristoneThe serum concentration of Mifepristone can be decreased when it is combined with Rifapentine.Approved, Investigational
MiltefosineThe serum concentration of Rifapentine can be increased when it is combined with Miltefosine.Approved
MirabegronThe metabolism of Mirabegron can be increased when combined with Rifapentine.Approved
MirtazapineThe metabolism of Mirtazapine can be increased when combined with Rifapentine.Approved
MoclobemideThe metabolism of Moclobemide can be increased when combined with Rifapentine.Approved
ModafinilThe metabolism of Modafinil can be increased when combined with Rifapentine.Approved, Investigational
MometasoneThe serum concentration of Mometasone can be decreased when it is combined with Rifapentine.Approved, Vet Approved
MonensinThe serum concentration of Rifapentine can be increased when it is combined with Monensin.Vet Approved
MontelukastThe metabolism of Montelukast can be increased when combined with Rifapentine.Approved
MorphineThe metabolism of Morphine can be increased when combined with Rifapentine.Approved, Investigational
MorphineThe serum concentration of Morphine can be decreased when it is combined with Rifapentine.Approved, Investigational
muraglitazarThe metabolism of muraglitazar can be increased when combined with Rifapentine.Investigational
Mycophenolate mofetilThe metabolism of Mycophenolate mofetil can be increased when combined with Rifapentine.Approved, Investigational
Mycophenolic acidThe serum concentration of Mycophenolic acid can be decreased when it is combined with Rifapentine.Approved
MyxothiazolThe serum concentration of Rifapentine can be increased when it is combined with Myxothiazol.Experimental
NadololThe serum concentration of Nadolol can be decreased when it is combined with Rifapentine.Approved
NaftifineThe serum concentration of Rifapentine can be increased when it is combined with Naftifine.Approved
NaftopidilThe serum concentration of Naftopidil can be decreased when it is combined with Rifapentine.Investigational
NaloxegolThe serum concentration of Naloxegol can be decreased when it is combined with Rifapentine.Approved
NaloxoneThe metabolism of Naloxone can be increased when combined with Rifapentine.Approved, Vet Approved
NaproxenThe metabolism of Naproxen can be increased when combined with Rifapentine.Approved, Vet Approved
NatamycinThe serum concentration of Rifapentine can be increased when it is combined with Natamycin.Approved
NateglinideThe metabolism of Nateglinide can be increased when combined with Rifapentine.Approved, Investigational
NCX 1022The serum concentration of NCX 1022 can be decreased when it is combined with Rifapentine.Investigational
NefazodoneThe metabolism of Nefazodone can be increased when combined with Rifapentine.Approved, Withdrawn
NelfinavirThe metabolism of Nelfinavir can be increased when combined with Rifapentine.Approved
NetupitantThe serum concentration of Netupitant can be decreased when it is combined with Rifapentine.Approved
NevirapineThe metabolism of Nevirapine can be increased when combined with Rifapentine.Approved
NicardipineThe metabolism of Nicardipine can be increased when combined with Rifapentine.Approved
NiclosamideThe metabolism of Niclosamide can be increased when combined with Rifapentine.Approved, Vet Approved
NicotineThe metabolism of Nicotine can be increased when combined with Rifapentine.Approved
NifedipineThe serum concentration of Nifedipine can be decreased when it is combined with Rifapentine.Approved
NiguldipineThe serum concentration of Niguldipine can be decreased when it is combined with Rifapentine.Experimental
NilotinibThe serum concentration of Nilotinib can be decreased when it is combined with Rifapentine.Approved, Investigational
NiludipineThe serum concentration of Niludipine can be decreased when it is combined with Rifapentine.Experimental
NilvadipineThe metabolism of Nilvadipine can be increased when combined with Rifapentine.Approved
NimesulideThe serum concentration of Nimesulide can be decreased when it is combined with Rifapentine.Approved, Withdrawn
NimodipineThe serum concentration of Nimodipine can be decreased when it is combined with Rifapentine.Approved
NisoldipineThe serum concentration of Nisoldipine can be decreased when it is combined with Rifapentine.Approved
NitrazepamThe metabolism of Nitrazepam can be increased when combined with Rifapentine.Approved
NitrendipineThe metabolism of Nitrendipine can be increased when combined with Rifapentine.Approved
NitroxolineThe serum concentration of Rifapentine can be increased when it is combined with Nitroxoline.Approved
NorelgestrominThe serum concentration of Norelgestromin can be decreased when it is combined with Rifapentine.Approved
NorethisteroneThe metabolism of Norethisterone can be increased when combined with Rifapentine.Approved
NorgestimateThe serum concentration of Norgestimate can be decreased when it is combined with Rifapentine.Approved
NorgestrelThe metabolism of Norgestrel can be increased when combined with Rifapentine.Approved
NortriptylineThe metabolism of Nortriptyline can be increased when combined with Rifapentine.Approved
NystatinThe serum concentration of Rifapentine can be increased when it is combined with Nystatin.Approved, Vet Approved
OlaparibThe serum concentration of Olaparib can be decreased when it is combined with Rifapentine.Approved
Oleoyl estroneThe serum concentration of Oleoyl estrone can be decreased when it is combined with Rifapentine.Investigational
OlodaterolThe metabolism of Olodaterol can be increased when combined with Rifapentine.Approved
OlopatadineThe metabolism of Olopatadine can be increased when combined with Rifapentine.Approved
OmbitasvirThe serum concentration of Ombitasvir can be decreased when it is combined with Rifapentine.Approved
OmeprazoleThe metabolism of Omeprazole can be increased when combined with Rifapentine.Approved, Investigational, Vet Approved
OndansetronThe metabolism of Ondansetron can be increased when combined with Rifapentine.Approved
OrphenadrineThe metabolism of Orphenadrine can be increased when combined with Rifapentine.Approved
OsimertinibThe serum concentration of Osimertinib can be decreased when it is combined with Rifapentine.Approved
OspemifeneThe metabolism of Ospemifene can be increased when combined with Rifapentine.Approved
OxaprozinThe metabolism of Oxaprozin can be increased when combined with Rifapentine.Approved
OxazepamThe metabolism of Oxazepam can be increased when combined with Rifapentine.Approved
OxiconazoleThe serum concentration of Rifapentine can be increased when it is combined with Oxiconazole.Approved
OxprenololThe serum concentration of Oxprenolol can be decreased when it is combined with Rifapentine.Approved
OxybutyninThe metabolism of Oxybutynin can be increased when combined with Rifapentine.Approved, Investigational
OxycodoneThe metabolism of Oxycodone can be increased when combined with Rifapentine.Approved, Illicit, Investigational
OxymorphoneThe metabolism of Oxymorphone can be increased when combined with Rifapentine.Approved, Investigational, Vet Approved
PaclitaxelThe metabolism of Paclitaxel can be increased when combined with Rifapentine.Approved, Vet Approved
pafuramidineThe serum concentration of Rifapentine can be increased when it is combined with pafuramidine.Investigational
PalbociclibThe serum concentration of Palbociclib can be decreased when it is combined with Rifapentine.Approved
PalonosetronThe metabolism of Palonosetron can be increased when combined with Rifapentine.Approved, Investigational
PanobinostatThe serum concentration of Panobinostat can be decreased when it is combined with Rifapentine.Approved, Investigational
PantoprazoleThe metabolism of Pantoprazole can be increased when combined with Rifapentine.Approved
ParamethadioneThe metabolism of Paramethadione can be increased when combined with Rifapentine.Approved
ParamethasoneThe metabolism of Paramethasone can be increased when combined with Rifapentine.Approved
ParecoxibThe metabolism of Parecoxib can be increased when combined with Rifapentine.Approved
ParicalcitolThe metabolism of Paricalcitol can be increased when combined with Rifapentine.Approved, Investigational
ParitaprevirThe serum concentration of Paritaprevir can be decreased when it is combined with Rifapentine.Approved
PazopanibThe serum concentration of Pazopanib can be decreased when it is combined with Rifapentine.Approved
PenbutololThe serum concentration of Penbutolol can be decreased when it is combined with Rifapentine.Approved, Investigational
PentamidineThe metabolism of Pentamidine can be increased when combined with Rifapentine.Approved
PentobarbitalThe metabolism of Pentobarbital can be increased when combined with Rifapentine.Approved, Vet Approved
PerampanelThe serum concentration of Perampanel can be decreased when it is combined with Rifapentine.Approved
PergolideThe metabolism of Pergolide can be increased when combined with Rifapentine.Approved, Vet Approved, Withdrawn
PerhexilineThe metabolism of Perhexiline can be increased when combined with Rifapentine.Approved
PermethrinThe metabolism of Permethrin can be increased when combined with Rifapentine.Approved, Investigational
PerphenazineThe metabolism of Perphenazine can be increased when combined with Rifapentine.Approved
PethidineThe metabolism of Pethidine can be increased when combined with Rifapentine.Approved
PhenacetinThe metabolism of Phenacetin can be increased when combined with Rifapentine.Withdrawn
PhenindioneThe metabolism of Phenindione can be increased when combined with Rifapentine.Approved
PhenobarbitalThe metabolism of Phenobarbital can be increased when combined with Rifapentine.Approved
PhenoxybenzamineThe metabolism of Phenoxybenzamine can be increased when combined with Rifapentine.Approved
PhenprocoumonThe metabolism of Phenprocoumon can be increased when combined with Rifapentine.Approved
PhenylbutazoneThe metabolism of Phenylbutazone can be increased when combined with Rifapentine.Approved, Vet Approved
PhenytoinThe metabolism of Phenytoin can be increased when combined with Rifapentine.Approved, Vet Approved
Picosulfuric acidThe therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Rifapentine.Approved
PilocarpineThe metabolism of Pilocarpine can be increased when combined with Rifapentine.Approved
PimecrolimusThe metabolism of Pimecrolimus can be increased when combined with Rifapentine.Approved, Investigational
PimozideThe metabolism of Pimozide can be increased when combined with Rifapentine.Approved
PinacidilThe metabolism of Pinacidil can be increased when combined with Rifapentine.Withdrawn
PinaveriumThe serum concentration of Pinaverium can be decreased when it is combined with Rifapentine.Approved
PindololThe serum concentration of Pindolol can be decreased when it is combined with Rifapentine.Approved
PioglitazoneThe metabolism of Pioglitazone can be increased when combined with Rifapentine.Approved, Investigational
PipotiazineThe metabolism of Pipotiazine can be increased when combined with Rifapentine.Approved
PiroxicamThe metabolism of Piroxicam can be increased when combined with Rifapentine.Approved, Investigational
PitavastatinThe serum concentration of Pitavastatin can be increased when it is combined with Rifapentine.Approved
PodofiloxThe metabolism of Podofilox can be increased when combined with Rifapentine.Approved
PomalidomideThe metabolism of Pomalidomide can be increased when combined with Rifapentine.Approved
PonatinibThe serum concentration of Ponatinib can be decreased when it is combined with Rifapentine.Approved
PosaconazoleThe metabolism of Posaconazole can be increased when combined with Rifapentine.Approved, Investigational, Vet Approved
PractololThe serum concentration of Practolol can be decreased when it is combined with Rifapentine.Approved
PrasteroneThe metabolism of Prasterone can be increased when combined with Rifapentine.Approved, Nutraceutical
PrasugrelThe metabolism of Prasugrel can be increased when combined with Rifapentine.Approved
PravastatinThe metabolism of Pravastatin can be increased when combined with Rifapentine.Approved
PrazepamThe metabolism of Prazepam can be increased when combined with Rifapentine.Approved, Illicit
PraziquantelThe serum concentration of Praziquantel can be decreased when it is combined with Rifapentine.Approved, Vet Approved
PrednicarbateThe serum concentration of Prednicarbate can be decreased when it is combined with Rifapentine.Approved
PrednisoloneThe metabolism of Prednisolone can be increased when combined with Rifapentine.Approved, Vet Approved
PrednisoloneThe serum concentration of Prednisolone can be decreased when it is combined with Rifapentine.Approved, Vet Approved
PrednisoneThe serum concentration of Prednisone can be decreased when it is combined with Rifapentine.Approved, Vet Approved
PregabalinThe serum concentration of Pregabalin can be decreased when it is combined with Rifapentine.Approved, Illicit, Investigational
PregnenoloneThe serum concentration of Pregnenolone can be decreased when it is combined with Rifapentine.Experimental
PrenylamineThe serum concentration of Prenylamine can be decreased when it is combined with Rifapentine.Withdrawn
PrimaquineThe metabolism of Primaquine can be increased when combined with Rifapentine.Approved
PrimidoneThe metabolism of Primidone can be increased when combined with Rifapentine.Approved, Vet Approved
ProchlorperazineThe metabolism of Prochlorperazine can be increased when combined with Rifapentine.Approved, Vet Approved
ProgesteroneThe metabolism of Progesterone can be increased when combined with Rifapentine.Approved, Vet Approved
ProguanilThe metabolism of Proguanil can be increased when combined with Rifapentine.Approved
PromazineThe metabolism of Promazine can be increased when combined with Rifapentine.Approved, Vet Approved
PropafenoneThe serum concentration of Propafenone can be decreased when it is combined with Rifapentine.Approved
PropofolThe metabolism of Propofol can be increased when combined with Rifapentine.Approved, Investigational, Vet Approved
PropranololThe metabolism of Propranolol can be increased when combined with Rifapentine.Approved, Investigational
PyrazinamideThe metabolism of Pyrazinamide can be increased when combined with Rifapentine.Approved
QuazepamThe metabolism of Quazepam can be increased when combined with Rifapentine.Approved, Illicit
QuetiapineThe serum concentration of Quetiapine can be decreased when it is combined with Rifapentine.Approved
QuinacrineThe metabolism of Quinacrine can be increased when combined with Rifapentine.Approved
QuinidineThe serum concentration of Quinidine can be decreased when it is combined with Rifapentine.Approved
QuinineThe metabolism of Quinine can be increased when combined with Rifapentine.Approved
RabeprazoleThe metabolism of Rabeprazole can be increased when combined with Rifapentine.Approved, Investigational
RadicicolThe serum concentration of Rifapentine can be increased when it is combined with Radicicol.Experimental
RaloxifeneThe metabolism of Raloxifene can be increased when combined with Rifapentine.Approved, Investigational
RaltegravirThe serum concentration of Raltegravir can be increased when it is combined with Rifapentine.Approved
RamelteonThe metabolism of Ramelteon can be increased when combined with Rifapentine.Approved, Investigational
RanolazineThe serum concentration of Ranolazine can be decreased when it is combined with Rifapentine.Approved, Investigational
ReboxetineThe metabolism of Reboxetine can be increased when combined with Rifapentine.Approved, Investigational
RegorafenibThe serum concentration of Regorafenib can be decreased when it is combined with Rifapentine.Approved
RepaglinideThe metabolism of Repaglinide can be increased when combined with Rifapentine.Approved, Investigational
RetapamulinThe metabolism of Retapamulin can be increased when combined with Rifapentine.Approved
RifabutinThe metabolism of Rifabutin can be increased when combined with Rifapentine.Approved
RifampicinThe metabolism of Rifampicin can be increased when combined with Rifapentine.Approved
RilpivirineThe serum concentration of Rilpivirine can be decreased when it is combined with Rifapentine.Approved
RimexoloneThe serum concentration of Rimexolone can be decreased when it is combined with Rifapentine.Approved
RimonabantThe metabolism of Rimonabant can be increased when combined with Rifapentine.Approved, Investigational
RiociguatThe metabolism of Riociguat can be increased when combined with Rifapentine.Approved
RisedronateThe serum concentration of Risedronate can be decreased when it is combined with Rifapentine.Approved, Investigational
RisperidoneThe metabolism of Risperidone can be increased when combined with Rifapentine.Approved, Investigational
RitonavirThe serum concentration of Ritonavir can be decreased when it is combined with Rifapentine.Approved, Investigational
RivaroxabanThe serum concentration of Rivaroxaban can be decreased when it is combined with Rifapentine.Approved
RofecoxibThe metabolism of Rofecoxib can be increased when combined with Rifapentine.Investigational, Withdrawn
RoflumilastThe serum concentration of Roflumilast can be decreased when it is combined with Rifapentine.Approved
RolapitantThe serum concentration of Rolapitant can be decreased when it is combined with Rifapentine.Approved
RomidepsinThe serum concentration of Romidepsin can be decreased when it is combined with Rifapentine.Approved, Investigational
RopiniroleThe metabolism of Ropinirole can be increased when combined with Rifapentine.Approved, Investigational
RopivacaineThe metabolism of Ropivacaine can be increased when combined with Rifapentine.Approved
RosiglitazoneThe metabolism of Rosiglitazone can be increased when combined with Rifapentine.Approved, Investigational
RosuvastatinThe metabolism of Rosuvastatin can be increased when combined with Rifapentine.Approved
RotigotineThe metabolism of Rotigotine can be increased when combined with Rifapentine.Approved
RoxithromycinThe metabolism of Roxithromycin can be increased when combined with Rifapentine.Approved, Withdrawn
RuxolitinibThe metabolism of Ruxolitinib can be increased when combined with Rifapentine.Approved
Salicylhydroxamic AcidThe serum concentration of Rifapentine can be increased when it is combined with Salicylhydroxamic Acid.Experimental
Salicylic acidThe metabolism of Salicylic acid can be increased when combined with Rifapentine.Approved, Vet Approved
SalmeterolThe metabolism of Salmeterol can be increased when combined with Rifapentine.Approved
SaquinavirThe metabolism of Saquinavir can be increased when combined with Rifapentine.Approved, Investigational
SaxagliptinThe serum concentration of Saxagliptin can be decreased when it is combined with Rifapentine.Approved
SecobarbitalThe metabolism of Secobarbital can be increased when combined with Rifapentine.Approved, Vet Approved
SelegilineThe metabolism of Selegiline can be increased when combined with Rifapentine.Approved, Investigational, Vet Approved
SelexipagThe metabolism of Selexipag can be increased when combined with Rifapentine.Approved
SeratrodastThe metabolism of Seratrodast can be increased when combined with Rifapentine.Approved, Investigational
SertaconazoleThe serum concentration of Rifapentine can be increased when it is combined with Sertaconazole.Approved
SertindoleThe metabolism of Sertindole can be increased when combined with Rifapentine.Approved, Withdrawn
SertralineThe metabolism of Sertraline can be increased when combined with Rifapentine.Approved
SevofluraneThe metabolism of Sevoflurane can be increased when combined with Rifapentine.Approved, Vet Approved
SibutramineThe metabolism of Sibutramine can be increased when combined with Rifapentine.Approved, Illicit, Investigational, Withdrawn
SildenafilThe metabolism of Sildenafil can be increased when combined with Rifapentine.Approved, Investigational
SilodosinThe metabolism of Silodosin can be increased when combined with Rifapentine.Approved
SimeprevirThe serum concentration of Simeprevir can be decreased when it is combined with Rifapentine.Approved
SimvastatinThe metabolism of Simvastatin can be increased when combined with Rifapentine.Approved
SinefunginThe serum concentration of Rifapentine can be increased when it is combined with Sinefungin.Experimental
SirolimusThe metabolism of Sirolimus can be increased when combined with Rifapentine.Approved, Investigational
SitagliptinThe metabolism of Sitagliptin can be increased when combined with Rifapentine.Approved, Investigational
SitaxentanThe metabolism of Sitaxentan can be increased when combined with Rifapentine.Approved, Investigational, Withdrawn
SofosbuvirThe serum concentration of Sofosbuvir can be decreased when it is combined with Rifapentine.Approved
SolifenacinThe metabolism of Solifenacin can be increased when combined with Rifapentine.Approved
SonidegibThe serum concentration of Sonidegib can be decreased when it is combined with Rifapentine.Approved, Investigational
SorafenibThe serum concentration of Sorafenib can be decreased when it is combined with Rifapentine.Approved, Investigational
SotalolThe serum concentration of Sotalol can be decreased when it is combined with Rifapentine.Approved
SpiramycinThe metabolism of Spiramycin can be increased when combined with Rifapentine.Approved
SufentanilThe metabolism of Sufentanil can be increased when combined with Rifapentine.Approved, Investigational
SulconazoleThe serum concentration of Rifapentine can be increased when it is combined with Sulconazole.Approved
SulfadiazineThe metabolism of Sulfadiazine can be increased when combined with Rifapentine.Approved, Vet Approved
SulfamethoxazoleThe metabolism of Sulfamethoxazole can be increased when combined with Rifapentine.Approved
SulfamoxoleThe metabolism of Sulfamoxole can be increased when combined with Rifapentine.Approved
SulfinpyrazoneThe metabolism of Sulfinpyrazone can be increased when combined with Rifapentine.Approved
SulfisoxazoleThe metabolism of Sulfisoxazole can be increased when combined with Rifapentine.Approved, Vet Approved
SunitinibThe serum concentration of Sunitinib can be decreased when it is combined with Rifapentine.Approved, Investigational
SuprofenThe metabolism of Suprofen can be increased when combined with Rifapentine.Approved, Withdrawn
SuvorexantThe serum concentration of Suvorexant can be decreased when it is combined with Rifapentine.Approved
Synthetic Conjugated Estrogens, AThe metabolism of Synthetic Conjugated Estrogens, A can be increased when combined with Rifapentine.Approved
Synthetic Conjugated Estrogens, BThe metabolism of Synthetic Conjugated Estrogens, B can be increased when combined with Rifapentine.Approved
TacrolimusThe metabolism of Tacrolimus can be increased when combined with Rifapentine.Approved, Investigational
TacrolimusThe serum concentration of Tacrolimus can be decreased when it is combined with Rifapentine.Approved, Investigational
TadalafilThe serum concentration of Tadalafil can be decreased when it is combined with Rifapentine.Approved, Investigational
TamoxifenThe metabolism of Tamoxifen can be increased when combined with Rifapentine.Approved
TamsulosinThe metabolism of Tamsulosin can be increased when combined with Rifapentine.Approved, Investigational
TapentadolThe metabolism of Tapentadol can be increased when combined with Rifapentine.Approved
TasimelteonThe serum concentration of Tasimelteon can be decreased when it is combined with Rifapentine.Approved
TasosartanThe metabolism of Tasosartan can be increased when combined with Rifapentine.Approved
Taurochenodeoxycholic acidThe metabolism of Taurochenodeoxycholic acid can be increased when combined with Rifapentine.Experimental
TavaboroleThe serum concentration of Rifapentine can be increased when it is combined with Tavaborole.Approved
TazaroteneThe metabolism of Tazarotene can be increased when combined with Rifapentine.Approved, Investigational
TelaprevirThe serum concentration of Telaprevir can be decreased when it is combined with Rifapentine.Approved
TelithromycinThe metabolism of Telithromycin can be increased when combined with Rifapentine.Approved
TemazepamThe metabolism of Temazepam can be increased when combined with Rifapentine.Approved
TemsirolimusThe serum concentration of Temsirolimus can be decreased when it is combined with Rifapentine.Approved
TeniposideThe metabolism of Teniposide can be increased when combined with Rifapentine.Approved
TenoxicamThe metabolism of Tenoxicam can be increased when combined with Rifapentine.Approved
TerbinafineThe metabolism of Terbinafine can be increased when combined with Rifapentine.Approved, Investigational, Vet Approved
TerconazoleThe serum concentration of Rifapentine can be increased when it is combined with Terconazole.Approved
TerfenadineThe metabolism of Terfenadine can be increased when combined with Rifapentine.Withdrawn
TesmilifeneThe metabolism of Tesmilifene can be increased when combined with Rifapentine.Investigational
TestosteroneThe metabolism of Testosterone can be increased when combined with Rifapentine.Approved, Investigational
TetracyclineThe metabolism of Tetracycline can be increased when combined with Rifapentine.Approved, Vet Approved
ThalidomideThe metabolism of Thalidomide can be increased when combined with Rifapentine.Approved, Investigational, Withdrawn
TheophyllineThe metabolism of Theophylline can be increased when combined with Rifapentine.Approved
ThiamylalThe metabolism of Thiamylal can be increased when combined with Rifapentine.Approved, Vet Approved
ThiopentalThe metabolism of Thiopental can be increased when combined with Rifapentine.Approved, Vet Approved
ThiotepaThe metabolism of Thiotepa can be increased when combined with Rifapentine.Approved
ThymolThe serum concentration of Rifapentine can be increased when it is combined with Thymol.Approved
TiagabineThe metabolism of Tiagabine can be increased when combined with Rifapentine.Approved
TicagrelorThe serum concentration of the active metabolites of Ticagrelor can be reduced when Ticagrelor is used in combination with Rifapentine resulting in a loss in efficacy.Approved
TiclopidineThe metabolism of Ticlopidine can be increased when combined with Rifapentine.Approved
TimololThe serum concentration of Timolol can be decreased when it is combined with Rifapentine.Approved
TinidazoleThe metabolism of Tinidazole can be increased when combined with Rifapentine.Approved, Investigational
TioconazoleThe serum concentration of Rifapentine can be increased when it is combined with Tioconazole.Approved
TiotropiumThe metabolism of Tiotropium can be increased when combined with Rifapentine.Approved
TipranavirThe metabolism of Tipranavir can be increased when combined with Rifapentine.Approved, Investigational
TixocortolThe serum concentration of Tixocortol can be decreased when it is combined with Rifapentine.Approved
TofacitinibThe serum concentration of Tofacitinib can be decreased when it is combined with Rifapentine.Approved, Investigational
TolbutamideThe metabolism of Tolbutamide can be increased when combined with Rifapentine.Approved
Tolfenamic AcidThe serum concentration of Tolfenamic Acid can be decreased when it is combined with Rifapentine.Approved
TolnaftateThe serum concentration of Rifapentine can be increased when it is combined with Tolnaftate.Approved, Vet Approved
TolterodineThe metabolism of Tolterodine can be increased when combined with Rifapentine.Approved, Investigational
TolvaptanThe serum concentration of Tolvaptan can be decreased when it is combined with Rifapentine.Approved
TorasemideThe metabolism of Torasemide can be increased when combined with Rifapentine.Approved
ToremifeneThe serum concentration of Toremifene can be decreased when it is combined with Rifapentine.Approved, Investigational
TrabectedinThe serum concentration of Trabectedin can be decreased when it is combined with Rifapentine.Approved, Investigational
TramadolThe metabolism of Tramadol can be increased when combined with Rifapentine.Approved, Investigational
TranilastThe serum concentration of Tranilast can be decreased when it is combined with Rifapentine.Approved, Investigational
Trastuzumab emtansineThe metabolism of Trastuzumab emtansine can be increased when combined with Rifapentine.Approved
TrazodoneThe metabolism of Trazodone can be increased when combined with Rifapentine.Approved, Investigational
TreprostinilThe serum concentration of Treprostinil can be decreased when it is combined with Rifapentine.Approved, Investigational
TretinoinThe metabolism of Tretinoin can be increased when combined with Rifapentine.Approved, Investigational, Nutraceutical
TriamcinoloneThe metabolism of Triamcinolone can be increased when combined with Rifapentine.Approved, Vet Approved
TriazolamThe metabolism of Triazolam can be increased when combined with Rifapentine.Approved
TrimethadioneThe metabolism of Trimethadione can be increased when combined with Rifapentine.Approved
TrimethoprimThe metabolism of Trimethoprim can be increased when combined with Rifapentine.Approved, Vet Approved
TrimetrexateThe serum concentration of Rifapentine can be increased when it is combined with Trimetrexate.Approved, Investigational
TrimipramineThe metabolism of Trimipramine can be increased when combined with Rifapentine.Approved
TroglitazoneThe metabolism of Troglitazone can be increased when combined with Rifapentine.Withdrawn
TroleandomycinThe metabolism of Troleandomycin can be increased when combined with Rifapentine.Approved
UdenafilThe metabolism of Udenafil can be increased when combined with Rifapentine.Approved, Investigational
UlipristalThe serum concentration of Ulipristal can be decreased when it is combined with Rifapentine.Approved
ValdecoxibThe metabolism of Valdecoxib can be increased when combined with Rifapentine.Investigational, Withdrawn
Valproic AcidThe metabolism of Valproic Acid can be increased when combined with Rifapentine.Approved, Investigational
ValsartanThe metabolism of Valsartan can be increased when combined with Rifapentine.Approved, Investigational
VandetanibThe serum concentration of Vandetanib can be decreased when it is combined with Rifapentine.Approved
VanoxerineThe metabolism of Vanoxerine can be increased when combined with Rifapentine.Investigational
VardenafilThe metabolism of Vardenafil can be increased when combined with Rifapentine.Approved
VemurafenibThe serum concentration of Vemurafenib can be decreased when it is combined with Rifapentine.Approved
VenetoclaxThe metabolism of Venetoclax can be increased when combined with Rifapentine.Approved
VenlafaxineThe metabolism of Venlafaxine can be increased when combined with Rifapentine.Approved
VerapamilThe metabolism of Verapamil can be increased when combined with Rifapentine.Approved
VicrivirocThe metabolism of Vicriviroc can be increased when combined with Rifapentine.Investigational
VilanterolThe metabolism of Vilanterol can be increased when combined with Rifapentine.Approved
VilazodoneThe serum concentration of Vilazodone can be decreased when it is combined with Rifapentine.Approved
VinblastineThe metabolism of Vinblastine can be increased when combined with Rifapentine.Approved
VincristineThe serum concentration of Vincristine can be decreased when it is combined with Rifapentine.Approved, Investigational
VincristineThe metabolism of Vincristine can be increased when combined with Rifapentine.Approved, Investigational
VindesineThe metabolism of Vindesine can be increased when combined with Rifapentine.Approved
VinorelbineThe metabolism of Vinorelbine can be increased when combined with Rifapentine.Approved, Investigational
VinpocetineThe serum concentration of Vinpocetine can be decreased when it is combined with Rifapentine.Investigational
VismodegibThe metabolism of Vismodegib can be increased when combined with Rifapentine.Approved
VorapaxarThe serum concentration of Vorapaxar can be decreased when it is combined with Rifapentine.Approved
VoriconazoleThe serum concentration of Rifapentine can be increased when it is combined with Voriconazole.Approved, Investigational
VortioxetineThe serum concentration of Vortioxetine can be decreased when it is combined with Rifapentine.Approved
WarfarinThe metabolism of Warfarin can be increased when combined with Rifapentine.Approved
XimelagatranThe metabolism of Ximelagatran can be increased when combined with Rifapentine.Approved, Investigational, Withdrawn
XylometazolineThe serum concentration of Xylometazoline can be decreased when it is combined with Rifapentine.Approved
YohimbineThe metabolism of Yohimbine can be increased when combined with Rifapentine.Approved, Vet Approved
ZafirlukastThe metabolism of Zafirlukast can be increased when combined with Rifapentine.Approved, Investigational
ZalcitabineThe metabolism of Zalcitabine can be increased when combined with Rifapentine.Approved
ZaleplonThe serum concentration of Zaleplon can be decreased when it is combined with Rifapentine.Approved, Illicit, Investigational
ZaltoprofenThe metabolism of Zaltoprofen can be increased when combined with Rifapentine.Approved
ZiconotideThe serum concentration of Ziconotide can be decreased when it is combined with Rifapentine.Approved
ZidovudineThe serum concentration of Zidovudine can be decreased when it is combined with Rifapentine.Approved
ZileutonThe metabolism of Zileuton can be increased when combined with Rifapentine.Approved, Investigational, Withdrawn
ZiprasidoneThe metabolism of Ziprasidone can be increased when combined with Rifapentine.Approved
ZolpidemThe serum concentration of Zolpidem can be decreased when it is combined with Rifapentine.Approved
ZomepiracThe metabolism of Zomepirac can be increased when combined with Rifapentine.Withdrawn
ZonisamideThe metabolism of Zonisamide can be increased when combined with Rifapentine.Approved, Investigational
ZopicloneThe metabolism of Zopiclone can be increased when combined with Rifapentine.Approved
ZuclopenthixolThe serum concentration of Zuclopenthixol can be decreased when it is combined with Rifapentine.Approved, Investigational
Food InteractionsNot Available
References
Synthesis ReferenceNot Available
General ReferencesNot Available
External Links
ATC CodesJ04AB05
AHFS CodesNot Available
PDB EntriesNot Available
FDA labelDownload (1.74 MB)
MSDSDownload (58.3 KB)
ADMET
Predicted ADMET features
PropertyValueProbability
Human Intestinal Absorption+0.6848
Blood Brain Barrier-0.9659
Caco-2 permeable-0.6609
P-glycoprotein substrateSubstrate0.8997
P-glycoprotein inhibitor IInhibitor0.7632
P-glycoprotein inhibitor IINon-inhibitor0.5252
Renal organic cation transporterNon-inhibitor0.8267
CYP450 2C9 substrateNon-substrate0.8555
CYP450 2D6 substrateNon-substrate0.9115
CYP450 3A4 substrateSubstrate0.7246
CYP450 1A2 substrateNon-inhibitor0.8865
CYP450 2C9 inhibitorNon-inhibitor0.8436
CYP450 2D6 inhibitorNon-inhibitor0.9073
CYP450 2C19 inhibitorNon-inhibitor0.8449
CYP450 3A4 inhibitorNon-inhibitor0.7042
CYP450 inhibitory promiscuityLow CYP Inhibitory Promiscuity0.8274
Ames testNon AMES toxic0.598
CarcinogenicityNon-carcinogens0.8187
BiodegradationNot ready biodegradable1.0
Rat acute toxicity2.3722 LD50, mol/kg Not applicable
hERG inhibition (predictor I)Weak inhibitor0.9221
hERG inhibition (predictor II)Inhibitor0.6821
ADMET data is predicted using admetSAR, a free tool for evaluating chemical ADMET properties. (23092397 )
Pharmacoeconomics
ManufacturersNot Available
Packagers
Dosage forms
FormRouteStrength
Tablet, film coatedOral150 mg/1
Prices
Unit descriptionCostUnit
Priftin 150 mg tablet3.96USD tablet
DrugBank does not sell nor buy drugs. Pricing information is supplied for informational purposes only.
PatentsNot Available
Properties
StateSolid
Experimental Properties
PropertyValueSource
logP4Not Available
Predicted Properties
PropertyValueSource
Water Solubility0.0213 mg/mLALOGPS
logP4.83ALOGPS
logP3.56ChemAxon
logS-4.6ALOGPS
pKa (Strongest Acidic)7.01ChemAxon
pKa (Strongest Basic)7.98ChemAxon
Physiological Charge1ChemAxon
Hydrogen Acceptor Count14ChemAxon
Hydrogen Donor Count6ChemAxon
Polar Surface Area220.15 Å2ChemAxon
Rotatable Bond Count6ChemAxon
Refractivity242 m3·mol-1ChemAxon
Polarizability93.14 Å3ChemAxon
Number of Rings6ChemAxon
Bioavailability0ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleYesChemAxon
Spectra
Mass Spec (NIST)Not Available
SpectraNot Available
Taxonomy
ClassificationNot classified

Targets

Kind
Protein
Organism
Mycobacterium tuberculosis
Pharmacological action
yes
Actions
inhibitor
General Function:
Transcription
Specific Function:
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
Gene Name:
rpoC
Uniprot ID:
P0A674
Molecular Weight:
146771.0 Da
References
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284 ]
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423 ]
  3. Williams DL, Spring L, Collins L, Miller LP, Heifets LB, Gangadharam PR, Gillis TP: Contribution of rpoB mutations to development of rifamycin cross-resistance in Mycobacterium tuberculosis. Antimicrob Agents Chemother. 1998 Jul;42(7):1853-7. [PubMed:9661035 ]
  4. Tupin A, Gualtieri M, Roquet-Baneres F, Morichaud Z, Brodolin K, Leonetti JP: Resistance to rifampicin: at the crossroads between ecological, genomic and medical concerns. Int J Antimicrob Agents. 2010 Jun;35(6):519-23. doi: 10.1016/j.ijantimicag.2009.12.017. Epub 2010 Feb 24. [PubMed:20185278 ]

Enzymes

Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inducer
General Function:
Steroid hydroxylase activity
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. In the epoxidation of arachidonic acid it generates only 14,15- and 11,12-cis-epoxyeicosatrienoic acids. It is the principal enzyme...
Gene Name:
CYP2C8
Uniprot ID:
P10632
Molecular Weight:
55824.275 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inducer
General Function:
Steroid hydroxylase activity
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. This enzyme contributes to the wide pharmacokinetics variability of the metabolism of drugs such as S-warfarin, diclofenac, phenyto...
Gene Name:
CYP2C9
Uniprot ID:
P11712
Molecular Weight:
55627.365 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inducer
General Function:
Vitamin d3 25-hydroxylase activity
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It performs a variety of oxidation reactions (e.g. caffeine 8-oxidation, omeprazole sulphoxidation, midazolam 1'-hydroxylation and midazolam 4-hydroxylation) of structurally unrelated compounds, including steroids, fatty acids, and xenobiot...
Gene Name:
CYP3A4
Uniprot ID:
P08684
Molecular Weight:
57342.67 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inducer
General Function:
Steroid hydroxylase activity
Specific Function:
Responsible for the metabolism of many drugs and environmental chemicals that it oxidizes. It is involved in the metabolism of drugs such as antiarrhythmics, adrenoceptor antagonists, and tricyclic antidepressants.
Gene Name:
CYP2D6
Uniprot ID:
P10635
Molecular Weight:
55768.94 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inducer
General Function:
Monooxygenase activity
Specific Function:
Exhibits low testosterone 6-beta-hydroxylase activity.
Gene Name:
CYP3A43
Uniprot ID:
Q9HB55
Molecular Weight:
57669.21 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inducer
General Function:
Oxygen binding
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
Gene Name:
CYP3A5
Uniprot ID:
P20815
Molecular Weight:
57108.065 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inducer
General Function:
Oxygen binding
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
Gene Name:
CYP3A7
Uniprot ID:
P24462
Molecular Weight:
57525.03 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
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Drug created on June 13, 2005 07:24 / Updated on August 17, 2016 12:23