Displaying drugs 751 - 775 of 11590 in total
Itraconazole
First synthesized in the early 1980s, itraconazole is a broad-spectrum triazole antifungal agent used to treat a variety of infections. It is a 1:1:1:1 racemic mixture of four diastereomers, made up of two enantiomeric pairs, each possessing three chiral centers. Itraconazole was first approved in the US in 1992 and...
Approved
Investigational
Matched Description: … to treat a variety of infections. ... First synthesized in the early 1980s, itraconazole is a broad-spectrum triazole antifungal agent used ... [A34257] It is a 1:1:1:1 racemic mixture of four diastereomers, made up of two enantiomeric pairs, each …
Entecavir
Entecavir is an oral antiviral drug used in the treatment of hepatitis B infection. It is marketed under the trade name Baraclude (BMS).
Entecavir is a guanine analogue that inhibits all three steps in the viral replication process, and the manufacturer claims that it is more efficacious than previous agents...
Approved
Investigational
Matched Description: … Entecavir is a guanine analogue that inhibits all three steps in the viral replication process, and the …
Decamethonium
Decamethonium is used in anesthesia to cause paralysis. It is a short acting depolarizing muscle relaxant. It is similar to acetylcholine and acts as a partial agonist of the nicotinic acetylcholine receptor.
Approved
Matched Description: … It is a short acting depolarizing muscle relaxant. ... It is similar to acetylcholine and acts as a partial agonist of the nicotinic acetylcholine receptor. …
Periciazine
Periciazine is a phenothiazine of the piperidine group. It has been shown to reduce pathologic arousal and affective tension in some psychotic patients, while the symptoms of abnormal mental integration are relatively unaffected. It is a sedative phenothiazine with weak antipsychotic properties. It also has adrenolytic, anticholinergic, metabolic and endocrine...
Approved
Investigational
Matched Description: … Periciazine is a phenothiazine of the piperidine group. ... It is a sedative phenothiazine with weak antipsychotic properties. ... phenothiazines, is presumed to act principally in the subcortical areas, by producing what has been described as a …
Voxelotor
Voxelotor is a novel hemoglobin S polymerization inhibitor for the treatment of sickle cell disease. This is a genetically inherited condition most prevalent in the Middle East, Africa, and certain parts of India. Sickle cell disease can lead to excruciating pain, stroke, infection, and various other complications arising from the...
Approved
Investigational
Matched Description: … Voxelotor is a novel hemoglobin S polymerization inhibitor for the treatment of sickle cell disease. ... This is a genetically inherited condition most prevalent in the Middle East, Africa, and certain parts ... [T734]
Voxelotor was granted accelerated FDA approval on November 25 2019, as it is likely to be a …
Ceftobiprole medocaril
Ceftobiprole medocaril is a prodrug of ceftobiprole, a fifth-generation semisynthetic cephalosporin antibacterial. Ceftobiprole is a broad-spectrum agent with demonstrated activity against both Gram-positive and Gram-negative bacteria, including antibiotic-resistant strains of Staphylcoccus aureus (methicillin-resistant Staphylococcus aureus; MRSA).
The EMA's Committee for Medicinal Products for Human Use (CHMP) adopted a negative opinion...
Approved
Experimental
Investigational
Matched Description: … Ceftobiprole medocaril is a prodrug of [ceftobiprole], a fifth-generation semisynthetic cephalosporin ... Ceftobiprole is a broad-spectrum agent with demonstrated activity against both Gram-positive and Gram-negative ... The EMA's Committee for Medicinal Products for Human Use (CHMP) adopted a negative opinion of ceftobiprole …
Metoprolol
Metoprolol is a selective beta-1 blocker commonly employed as the succinate and tartrate derivatives depending if the formulation is designed to be of immediate release or extended release.[A175159, L5530] The possibility of the generation of these formulations comes from the lower systemic bioavailability of the succinate derivative. To this date,...
Approved
Investigational
Matched Description: … Metoprolol is a selective beta-1 blocker commonly employed as the succinate and tartrate derivatives …
Matched Mixtures name: … METOPROLOL COM ABZ100/12.5 …
Matched Mixtures name: … METOPROLOL COM ABZ100/12.5 …
Fedratinib
Fedratinib, also known as SAR302503 and TG101348, is a tyrosine kinase inhibitor used to treat intermediate-2 and high risk primary and secondary myelofibrosis.[A183176,L8090] It is an anilinopyrimidine derivative. Fedratinib was granted FDA approval on August 16, 2019.
Approved
Investigational
Matched Description: … Fedratinib, also known as SAR302503 and TG101348, is a tyrosine kinase inhibitor used to treat intermediate …
Triptorelin
Triptorelin is a synthetic decapeptide agonist analog of luteinizing hormone releasing hormone (LHRH). Possessing greater potency than endogenous LHRH, triptorelin reversibly represses gonadotropin secretion. After chronic, continuous administration, this agent effects sustained decreases in LH and FSH production and testicular and ovarian steroidogenesis. Serum testosterone concentrations may fall to levels...
Approved
Vet approved
Matched Description: … Triptorelin is a synthetic decapeptide agonist analog of luteinizing hormone releasing hormone (LHRH) …
Dalbavancin
Dalbavancin is a second-generation lipoglycopeptide antibiotic that was designed to improve on the natural glycopeptides currently available, such as vancomycin and teicoplanin [A4072, A4073]. Modifications from these older glycoprotein classes facilitated a similar mechanism of action for dalbavancin but with increased activity and once-weekly dosing [FDA Label, F2356, A4072, A4073]....
Approved
Investigational
Matched Description: … Dalbavancin is a second-generation lipoglycopeptide antibiotic that was designed to improve on the natural ... Modifications from these older glycoprotein classes facilitated a similar mechanism of action for dalbavancin …
Cefotiam
One of the cephalosporins that has a broad spectrum of activity against both gram-positive and gram-negative microorganisms.
Approved
Investigational
Matched Description: … One of the cephalosporins that has a broad spectrum of activity against both gram-positive and gram-negative …
Fluoxymesterone
An anabolic steroid that has been used in the treatment of male hypogonadism, delayed puberty in males, and in the treatment of breast neoplasms in women.
Approved
Illicit
Matched Iupac: … 9b-fluoro-1,10-dihydroxy-1,9a,11a-trimethyl-1H,2H,3H,3aH,3bH,4H,5H,7H,8H,9H,9aH,9bH,10H,11H,11aH-cyclopenta[a] …
Pentosan polysulfate
Pentosan polysulfate is a sulfated pentosyl polysaccharide with heparin-like properties.
Approved
Matched Description: … Pentosan polysulfate is a sulfated pentosyl polysaccharide with heparin-like properties. …
Hydrocortisone butyrate
Approved
Vet approved
Matched Iupac: … hydroxyacetyl)-9a,11a-dimethyl-7-oxo-1H,2H,3H,3aH,3bH,4H,5H,7H,8H,9H,9aH,9bH,10H,11H,11aH-cyclopenta[a] …
Diflorasone
Diflorasone is a topical corticosteroid used to treat itching and inflammation of the skin.
Approved
Matched Iupac: … dihydroxy-1-(2-hydroxyacetyl)-2,9a,11a-trimethyl-1H,2H,3H,3aH,3bH,4H,5H,7H,9aH,9bH,10H,11H,11aH-cyclopenta[a] …
Matched Description: … Diflorasone is a topical corticosteroid used to treat itching and inflammation of the skin. …
Matched Description: … Diflorasone is a topical corticosteroid used to treat itching and inflammation of the skin. …
Ganciclovir
An acyclovir analog that is a potent inhibitor of the Herpesvirus family including cytomegalovirus. Ganciclovir is used to treat complications from AIDS-associated cytomegalovirus infections.
Approved
Investigational
Matched Description: … An acyclovir analog that is a potent inhibitor of the Herpesvirus family including cytomegalovirus. …
Cobalt chloride
Approved
Experimental
Matched Categories: … Compounds used in a research, industrial, or household setting …
Nitric Oxide
Nitric oxide or Nitrogen monoxide is a chemical compound with chemical formula NO. This gas is an important signaling molecule in the body of mammals including humans and is an extremely important intermediate in the chemical industry. It is also a toxic air pollutant produced by automobile engines and power...
Approved
Matched Description: … Nitric oxide or Nitrogen monoxide is a chemical compound with chemical formula NO. ... It is also a toxic air pollutant produced by automobile engines and power plants. ... The nitric oxide molecule is a free radical, which is relevant to understanding its high reactivity. …
Matched Categories: … Compounds used in a research, industrial, or household setting …
Matched Categories: … Compounds used in a research, industrial, or household setting …
Nelfinavir
Nelfinavir is a potent HIV-1 protease inhibitor. It is used in combination with other antiviral drugs in the treatment of HIV in both adults and children. Nelfinavir inhibits the HIV viral proteinase enzyme which prevents cleavage of the gag-pol polyprotein, resulting in noninfectious, immature viral particles.
Approved
Matched Description: … Nelfinavir is a potent HIV-1 protease inhibitor. …
Human adenovirus e serotype 4 strain cl-68578 antigen
Human adenovirus e serotype 4 strain cl-68578 antigen is a vaccine.
Approved
Matched Description: … Human adenovirus e serotype 4 strain cl-68578 antigen is a vaccine. …
Ofloxacin
A synthetic fluoroquinolone (fluoroquinolones) antibacterial agent that inhibits the supercoiling activity of bacterial DNA gyrase, halting DNA replication.
Approved
Matched Description: … A synthetic fluoroquinolone (fluoroquinolones) antibacterial agent that inhibits the supercoiling activity …
Alcloxa
Approved
Nirmatrelvir
Nirmatrelvir (PF-07321332) is an orally bioavailable 3C-like protease (3CLPRO) inhibitor that is the subject of clinical trial NCT04756531. 3CLPRO is responsible for cleaving polyproteins 1a and 1ab of SARS-CoV-2. Without the activity of the SARS-CoV-2 3CLPRO, nonstructural proteins (including proteases) cannot be released to perform their functions, inhibiting viral replication.[A234224,A234229,A234234]...
Approved
Investigational
Matched Description: … [L33359]
In December 2021, the FDA granted an emergency use authorization to Paxlovid, a co-packaged …
Lapyrium
Lapyrium is a quaternary ammonium cation used as a surfactant, antistatic agent, and biocide in various cosmetic products . It is commonly found formulated as lapyrium chloride.
Approved
Matched Description: … Lapyrium is a quaternary ammonium cation used as a surfactant, antistatic agent, and biocide in various …
Displaying drugs 751 - 775 of 11590 in total