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Displaying drugs 826 - 850 of 13645 in total

Flotufolastat F-18

Flotufolastat F-18 (18F-rhPSMA-7.3) is an 18F-labeled ligand that targets the prostate-specific membrane antigen (PSMA).[A259846,L46731] In patients with recurrent prostate cancer that require localized treatment, the use of 18F-labeled ligands for positron emission tomography (PET) offers accurate diagnostic imaging. Unlike 68Ga-labeled PSMA-targeting ligands, 18F-labeled compounds targeting this protein have a longer...
Approved
Investigational
Matched Description: … a high level of accumulation in tumors. ... in men with prostate cancer with suspected metastasis who are candidates for initial definitive therapy ... [A259846] In May 2023, the FDA approved the use of flotufolastat F-18 for PET of PSMA-positive lesions …

Fluprednisolone

A synthetic glucocorticoid with anti-inflammatory properties.
Approved
Matched Iupac: … dihydroxy-1-(2-hydroxyacetyl)-9a,11a-dimethyl-1H,2H,3H,3aH,3bH,4H,5H,7H,9aH,9bH,10H,11H,11aH-cyclopenta[a] …
Matched Description: … A synthetic glucocorticoid with anti-inflammatory properties. …
Matched Categories: … Corticosteroids for Systemic Use …

Fidanacogene elaparvovec

Fidanacogene elaparvovec is a liver-specific adeno-associated virus (AAV) vector containing a codon-optimized human coagulation FIX gene that was investigated as a potential treatment for hemophilia B. Hemophilia B is a rare X-linked genetic disorder characterized by abnormal coagulation due to dysfunctional coagulation factor IX with a male incidence estimated to...
Approved
Investigational
Matched Description: … week for bleeding or as prophylaxis and 2–3 times a week for severe hemophilia, although this carries ... dysfunctional coagulation factor IX with a male incidence estimated to be 1 in 30,000 male births worldwide ... human coagulation FIX gene that was investigated as a potential treatment for hemophilia B. …

Eptifibatide

Synthetic cyclic hexapeptide that binds to platelet receptor glycoprotein and inhibits platelet aggregation. Derived from venom of the Southeastern pygmy rattlesnake (Sistrurus miliarus barbouri), eptifibatide is a cyclic heptapeptide that belongs to the class of arginin-glycin-aspartat-mimetics.
Approved
Investigational
Matched Description: … Derived from venom of the Southeastern pygmy rattlesnake (Sistrurus miliarus barbouri), eptifibatide is a …

Nifurtimox

Chagas disease, caused by a parasite known as Trypanosoma cruzi (T.cruzi), is a vector-transmitted disease affecting animals and humans in the Americas. It is commonly known as American Trypanosomiasis. The CDC estimates that approximately 8 million people in Central America, South America, and Mexico are infected with T. cruzi, without...
Approved
Investigational
Matched Description: … On August 6 2020, accelerated FDA approval was granted for its use in pediatric patients in response ... [L15366] Nifurtimox, developed by Bayer, is a nitrofuran antiprotozoal drug used in the treatment ... without the need for pill-cutting devices. …

Primaquine

An aminoquinoline that is given by mouth to produce a radical cure and prevent relapse of vivax and ovale malarias following treatment with a blood schizontocide. It has also been used to prevent transmission of falciparum malaria by those returning to areas where there is a potential for re-introduction of...
Approved
Matched Description: … potential for re-introduction of malaria. ... malarias following treatment with a blood schizontocide. ... An aminoquinoline that is given by mouth to produce a radical cure and prevent relapse of vivax and ovale …
Matched Categories: … Antibiotics for Pneumocystis Pneumonia …

Influenza B virus B/Victoria/705/2018 BVR-11 antigen (formaldehyde inactivated)

A seasonally-specific component of the influenza vaccine. The influenza vaccine, also known as the "flu shot", is a vaccine that protects against infection from the influenza viruses. Vaccines provide protection from influenza by exposing the immune system to the virus (or parts of the virus) which stimulates an immunological defence...
Approved
Matched Description: … Inactivated vaccines contain a virus particle that has been grown in media and then subsequently killed ... A seasonally-specific component of the influenza vaccine. ... The influenza vaccine, also known as the "flu shot", is a vaccine that protects against infection from …
Matched Mixtures name: … FLUAD Injektionssuspension in einer Fertigspritze ... Sandovac Injektionssuspension in einer Fertigspritze …

Fluorouracil

A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the thymidylate synthetase conversion of deoxyuridylic acid to thymidylic acid.
Approved
Matched Description: … A pyrimidine analog that is an antineoplastic antimetabolite. …
Matched Categories: … Cytochrome P-450 CYP1A2 Substrates with a Narrow Therapeutic Index ... Cytochrome P-450 CYP2A6 Substrates with a Narrow Therapeutic Index ... Cytochrome P-450 CYP2C8 Substrates with a Narrow Therapeutic Index …

Rolitetracycline

A pyrrolidinylmethyl tetracycline.
Approved
Matched Description: … A pyrrolidinylmethyl tetracycline. …
Matched Categories: … Antibacterials for Systemic Use ... Antiinfectives for Systemic Use …

Etomidate

Imidazole derivative anesthetic and hypnotic with little effect on blood gases, ventilation, or the cardiovascular system. It has been proposed as an induction anesthetic.
Approved
Matched Products: … ETOMIDATE-LIPURO 20MG/10ML INJ IN 10ML GA …

Tislelizumab

Tislelizumab is a humanized monoclonal IgG4 antibody against programmed death receptor-1 (PD-1). It was engineered to have a nullified Fc portion, thus minimizing binding to FcγR on macrophages and limiting treatment resistance via antibody-dependent phagocytosis. By blocking PD-L1/PD-L2–mediated cell signaling, tislelizumab restores T-cell function through cytokine production, resulting in immune-mediated...
Approved
Investigational
Matched Description: … [A262924] On September 25, 2023, tislelizumab gained EMA approval as a monotherapy for adults with ... median overall survival rate was observed for tislelizumab treatment compared to 6.3-month for chemotherapy ... mediated cell signaling, tislelizumab restores T-cell function through cytokine production, resulting in …

Ipilimumab

Ipilimumab is a fully humanized IgG1 monoclonal antibody that blocks cytotoxic T lymphocyte antigen-4 (CTLA-4). Blocking CTLA-4 removes an inhibitory signal from reducing the activity of T lymphocytes.[A35065,A35080,L12126] Ipilimumab was developed by Bristol-Myers Squibb and Medarex. Ipilimumab was granted FDA approval on 25 March 2011.
Approved
Matched Description: … Ipilimumab is a fully humanized IgG1 monoclonal antibody that blocks cytotoxic T lymphocyte antigen-4 …

Azficel-T

Azficel-T is an autologous cellular product composed of fibroblasts indicated for improvement of the appearance of moderate to severe nasolabial fold wrinkles in adults. Dermal fibroblasts are collected from the post-auricular biopsy tissue and aseptically expanded using standard tissue-culture procedures until sufficient cells for three doses are obtained [FDA Label]....
Approved
Investigational
Matched Description: … As a replacement for lost dermal constituents in the aging or skin deformation process, treatment with ... Expanded cells are then suspended in a cell medium. ... Azficel-T is marketed in the US as Laviv for intradermal injection. …

Iopanoic acid

Iopanoic acid contains iodine and is useful as a contrast medium in cholecystography.
Approved
Withdrawn
Matched Description: … Iopanoic acid contains iodine and is useful as a contrast medium in cholecystography. …
Matched Categories: … Compounds used in a research, industrial, or household setting …

Lodoxamide

Lodoxamide is a mast-cell stabilizer for topical administration into the eye. Mast-cell stabilizers, first one approved being cromolyn sodium, are used in treatment of ocular hypersensitivity reactions such as vernal conjunctivitis. These conditions often require treatment with anti-inflammatory medications such as ophthalmic NSAIDs or topical steroids which may cause systemic...
Approved
Matched Description: … Lodoxamide is a mast-cell stabilizer for topical administration into the eye. ... Mast-cell stabilizers, first one approved being cromolyn sodium, are used in treatment of ocular hypersensitivity …

Fenoterol

Fenoterol is an adrenergic beta-2 agonist that is used as a bronchodilator and tocolytic.
Approved
Investigational
Matched Description: … Fenoterol is an adrenergic beta-2 agonist that is used as a bronchodilator and tocolytic. …
Matched Mixtures name: … Duovent Nebuliser solution in Unit Dose Vial 4ml …
Matched Categories: … Adrenergics for Systemic Use ... Drugs for Obstructive Airway Diseases …

Iodoform

Iodoform is an organoiodine compound with the formula CHI3 and a tetrahedral molecular geometry. It is a relatively water-insoluble yellow solid that is chemically reactive in free-radical reactions . Due to its antimicrobial properties following topical administration, minimal levels of iodoform may be found in disinfectants and it is more...
Approved
Experimental
Vet approved
Matched Description: … be found in disinfectants and it is more primarily used for veterinary purposes. ... It is a relatively water-insoluble yellow solid that is chemically reactive in free-radical reactions ... Due to its antimicrobial properties following topical administration, minimal levels of iodoform may …

Peach

Peach allergenic extract is used in allergenic testing.
Approved
Matched Description: … Peach allergenic extract is used in allergenic testing. …

Quazepam

Quazepam is a trifluoroethyl benzodiazepine derivative. It was first approved in the US in 1985 and is used as a hypnotic for the treatment of insomnia. It appears to be unique amongst other benzodiazepine derivatives in its relatively high affinity for sleep-promoting α1 subunit-containing GABAA receptors and low affinity for...
Approved
Illicit
Matched Description: … It was first approved in the US in 1985 and is used as a hypnotic for the treatment of insomnia. ... for sleep-promoting α1 subunit-containing GABAA receptors and low affinity for other receptors ... Quazepam is a trifluoroethyl benzodiazepine derivative. …

Besifloxacin

Besifloxacin is a fourth generation fluoroquinolone-type opthalmic antibiotic for the treatment of bacterial conjunctivitis. FDA approved on May 28, 2009.
Approved
Matched Description: … Besifloxacin is a fourth generation fluoroquinolone-type opthalmic antibiotic for the treatment of bacterial …

Glyburide

Glyburide is a second generation sulfonylurea used to treat patients with diabetes mellitus type II. It is typically given to patients who cannot be managed with the standard first line therapy, metformin. Glyburide stimulates insulin secretion through the closure of ATP-sensitive potassium channels on beta cells, raising intracellular potassium and...
Approved
Matched Description: … Glyburide is a second generation sulfonylurea used to treat patients with diabetes mellitus type II. ... [L8117] A formulation with metformin was granted FDA approval on on 31 July 2000.[L8120] …
Matched Categories: … Drugs Used in Diabetes …

Enoximone

Enoximone is a selective phosphodiesterase inhibitor with vasodilating and positive inotropic activity that does not cause changes in myocardial oxygen consumption. It is used in patients with congestive heart failure. Trials were halted in the U.S., but the drug is used in various countries.
Approved
Investigational
Matched Description: … Enoximone is a selective phosphodiesterase inhibitor with vasodilating and positive inotropic activity ... Trials were halted in the U.S., but the drug is used in various countries. ... It is used in patients with congestive heart failure. …
Matched Categories: … Compounds used in a research, industrial, or household setting …

Selumetinib

Activation of the Raf-MEK-ERK signalling pathway is known to be implemented in several types of malignancies; thus, mitogen-activated protein kinase kinase (MEK) inhibitors such as selumetinib are important tools that can target the problematic overactivity of this pathway. Results from clinical trials investigating earlier developed MEK inhibitors were underwhelming. However,...
Approved
Investigational
Matched Description: … of Neurofibromatosis type 1 (NF-1) in a limited age group. ... to its continued investigation for the treatment of various types of tumours in Phase II trials. ... [A193611] Currently, the novel MEK 1 / 2 inhibitor, selumetinib, is approved solely for the treatment …

Dipivefrin

Dipivefrin is a prodrug of adrenaline, which is used to treat glaucoma. It is available as ophthalmic solution (eye drops).
Approved
Matched Description: … Dipivefrin is a prodrug of adrenaline, which is used to treat glaucoma. …
Matched Categories: … Sympathomimetics in Glaucoma Therapy …

Darifenacin

Darifenacin (Enablex®, Novartis) is a medication used to treat urinary incontinence. Darifenacin blocks M3 muscarinic acetylcholine receptors, which mediate bladder muscle contractions. This block reduces the urgency to urinate and so it should not be used in people with urinary retention. It is unknown if M3 receptor selectivity is clinically...
Approved
Investigational
Matched Description: … Darifenacin (Enablex®, Novartis) is a medication used to treat urinary incontinence. ... This block reduces the urgency to urinate and so it should not be used in people with urinary retention ... It is unknown if M3 receptor selectivity is clinically advantageous in overactive bladder syndrome treatments …
Matched Categories: … Drugs for Urinary Frequency and Incontinence …
Displaying drugs 826 - 850 of 13645 in total