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Displaying drugs 101 - 125 of 650 in total

MM-111

MM-111 is a novel bispecific antibody fusion protein that co-targets the the epidermal growth factor family receptor tyrosine kinases, ERBB2 and ERBB3.
Investigational
Matched Synonyms: … Antibody bispecific for erbb2 and erbb3 …
Matched Description: … fusion protein that co-targets the the epidermal growth factor family receptor tyrosine kinases, ERBB2 and …
Matched Categories: … Amino Acids, Peptides, and Proteins …

CLL1-CD33 compound chimeric antigen receptor T cells

Investigational
Matched Synonyms: … Chimeric Antigen Receptor immunotherapy directed against CLL-1 and CD33 …

Propafenone

An antiarrhythmia agent that is particularly effective in ventricular arrhythmias. It also has weak beta-blocking activity. The drug is generally well tolerated.
Approved
Matched Salts name: … Propafenone hydrochloride …
Matched Products: … Propafenone Hydrochloride ... Propafenone hydrochloride ... Propafenone Hydrochloride SR …

Ketamine

Ketamine is an NMDA receptor antagonist with a potent anesthetic effect. It was developed in 1963 as a replacement for phencyclidine (PCP) by Calvin Stevens at Parke Davis Laboratories. It started being used for veterinary purposes in Belgium and in 1964 was proven that compared to PCP, it produced minor...
Approved
Vet approved
Matched Description: … it produced minor hallucinogenic effects and shorter psychotomimetic effects. ... It started being used for veterinary purposes in Belgium and in 1964 was proven that compared to PCP, ... It was FDA approved in 1970, and from there, it has been used as an anesthetic for children or patients …
Matched Salts name: … Ketamine hydrochloride …
Matched Categories: … Amino Acids, Peptides, and Proteins …
Matched Products: … Ketamine Hydrochloride ... KETAMINE HYDROCHLORIDE ... Ketamine Hydrochloride Injection USP …

3-(Mercaptomethylene)Pyridine

Experimental
Matched Name: … 3-(Mercaptomethylene)Pyridine …

Antihemophilic factor, human recombinant

Human recombinant antihemophilic factor (AHF) or Factor VIII, 2332 residues, glycosylated, produced by CHO cells
Approved
Investigational
Matched Categories: … Blood and Blood Forming Organs ... Amino Acids, Peptides, and Proteins …
Matched Products: … ADVATE 250IU, POWDER AND SOLVENT FOR SOLUTION FOR INJECTION ... ADVATE 500IU, POWDER AND SOLVENT FOR SOLUTION FOR INJECTION ... ADVATE 1000IU, POWDER AND SOLVENT FOR SOLUTION FOR INJECTION …

Dexmethylphenidate

Dexmethylphenidate is the dextrorotary form of methylphenidate introduced in 2002 . It is a norepinephrine-dopamine reuptake inhibitor (NDRI) and thus a psychostimulant . It is used for treatment of Attention Deficit Hyperactivity Disorder (ADHD)[Label,A177181]. The d-isomer is thought to have greater effect with fewer side effects than the l-isomer or...
Approved
Investigational
Matched Description: … It is a norepinephrine-dopamine reuptake inhibitor (NDRI) and thus a psychostimulant[A177193]. …
Matched Salts name: … Dexmethylphenidate hydrochloride …
Matched Categories: … Methylphenidate and isomer ... dexmethylphenidate and serdexmethylphenidate ... Psychostimulants, Agents Used for ADHD and Nootropics …
Matched Products: … Dexmethylphenidate Hydrochloride ... Dexmethylphenidate hydrochloride ... Dexmethylphenidate Hydrochloride Extended-Release …

Coagulation factor VIIa Recombinant Human

Recombinant human coagulation Factor VIIa (rFVIIa), intended for promoting hemostasis by activating the extrinsic pathway of the coagulation cascade. NovoSeven is a vitamin K-dependent glycoprotein consisting of 406 amino acid residues. Cloned and expressed in hamster kidney cells, the protein is catalytically active in a two-chain form.
Approved
Matched Description: … Cloned and expressed in hamster kidney cells, the protein is catalytically active in a two-chain form …
Matched Categories: … Enzymes and Coenzymes ... Blood and Blood Forming Organs ... Amino Acids, Peptides, and Proteins …
Matched Products: … powder and solvent for solution for injection 2mg ... powder and solvent for solution for injection 1mg ... NOVOSEVEN 2MG POWDER AND SOLVENT FOR SOLUTION FOR INJECTION …

Reteplase

Human tissue plasminogen activator, purified, glycosylated, 355 residues purified from CHO cells. Retavase is considered a "third-generation" thrombolytic agent, genetically engineered to retain and delete certain portions of human tPA. Retavase is a deletion mutein of human tPA formed by deleting various amino acids present in endogenous human tPA. Retavase...
Approved
Investigational
Matched Synonyms: … Human t-PA (residues 1-3 and 176-527) …
Matched Description: … Retavase contains 355 of the 527 amino acids of native human tPA (amino acids 1-3 and 176-527), and retains ... the activity-related kringle-2 and serine protease domains of human tPA. ... Retavase is considered a "third-generation" thrombolytic agent, genetically engineered to retain and …
Matched Categories: … Enzymes and Coenzymes ... Blood and Blood Forming Organs ... Amino Acids, Peptides, and Proteins …

Colestipol

Bile acid sequestrants like colestipol have been in use since the 1970s.[FDA Label, F4555, F4567, L6262] And even though such an agent may very well be useful in reducing elevated cholesterol levels and decreasing the risk for atherosclerotic vascular disease due to hypercholesterolemia, colestipol is still generally only employed as...
Approved
Matched Synonyms: … Copolymer of bis(2-aminoethyl)amine and 2-(chloromethyl)oxirane …
Matched Description: … [FDA Label, F4555, F4567, L6262] And even though such an agent may very well be useful in reducing elevated ... , colestipol is still generally only employed as an adjunct therapy and the relatively physical nature ... cholesterol levels and decreasing the risk for atherosclerotic vascular disease due to hypercholesterolemia …
Matched Salts name: … Colestipol hydrochloride …
Matched Products: … Colestipol Hydrochloride ... Colestipol hydrochloride …

Dicyclomine

Dicyclomine is a muscarinic M1, M3, and M2 receptor antagonist as well as a non-competitive inhibitor of histamine and bradykinin used to treat spasms of the intestines seen in functional bowel disorder and irritable bowel syndrome.[A6556,A182555,A234659,L7967] Though it is commonly prescribed, its recommendation may have been based on a small...
Approved
Matched Description: … and irritable bowel syndrome. ... Dicyclomine is a muscarinic M1, M3, and M2 receptor antagonist as well as a non-competitive inhibitor ... of histamine and bradykinin used to treat spasms of the intestines seen in functional bowel disorder …
Matched Salts name: … Dicyclomine hydrochloride …
Matched Categories: … Alimentary Tract and Metabolism …
Matched Products: … Dicyclomine Hydrochloride ... Dicyclomine hydrochloride ... Dicyclomine Hydrochloride USP …

Turoctocog alfa

Turoctocog alfa is a recombinant factor VIII (rFVIII) with a truncated B-domain made from the sequence coding for 10 amino acids from the N-terminus and 11 amino acids from the C-terminus of the naturally occurring B-domain. Turoctocog alfa is produced in Chinese hamster ovary (CHO) cells without addition of any...
Approved
Investigational
Matched Description: … [A31504] It was developped by Novo Nordisk and FDA approved in October 16, 2013.[L1104] ... rFVIII) with a truncated B-domain made from the sequence coding for 10 amino acids from the N-terminus and ... secretion, some rFVIII molecules are cleaved at the C-terminal of the heavy chain (HC) at amino acid 720, and …
Matched Categories: … Amino Acids, Peptides, and Proteins …
Matched Products: … NovoEight 500IU Powder and Solvent for Solution for Injection ... NovoEight 1000IU Powder and Solvent for Solution for Injection ... NovoEight® 250IU Powder and Solvent for Solution for Injection …

Clomipramine

Clomipramine, the 3-chloro analog of imipramine, is a dibenzazepine-derivative tricyclic antidepressant (TCA). TCAs are structurally similar to phenothiazines. They contain a tricyclic ring system with an alkyl amine substituent on the central ring. In non-depressed individuals, clomipramine does not affect mood or arousal, but may cause sedation. In depressed individuals,...
Approved
Investigational
Vet approved
Matched Description: … TCAs are potent inhibitors of serotonin and norepinephrine reuptake. ... , are more potent inhibitors of serotonin reuptake than secondary amine TCAs, such as nortriptyline and ... receptors, which accounts for their sedative, hypotensive and anticholinergic effects (e.g. blurred …
Matched Salts name: … Clomipramine hydrochloride …
Matched Categories: … Tricyclics and Other Norepinephrine-reuptake Inhibitors …
Matched Products: … Clomipramine Hydrochloride ... clomiPRAMINE Hydrochloride ... Clomipramine hydrochloride …

Valganciclovir

Valganciclovir hydrochloride (Valcyte, manufactured by Roche) is an antiviral medication used to treat cytomegalovirus infections. As the L-valyl ester of ganciclovir, it is actually a prodrug for ganciclovir. After oral administration, it is rapidly converted to ganciclovir by intestinal and hepatic esterases.
Approved
Investigational
Matched Description: … Valganciclovir hydrochloride (Valcyte, manufactured by Roche) is an antiviral medication used to treat ... After oral administration, it is rapidly converted to ganciclovir by intestinal and hepatic esterases …
Matched Salts name: … Valganciclovir hydrochloride …
Matched Categories: … Ganciclovir and prodrug ... Nucleosides and Nucleotides ... Nucleosides and Nucleotides Excl. Reverse Transcriptase Inhibitors …
Matched Products: … Valganciclovir Hydrochloride ... Valganciclovir hydrochloride ... Valganciclovir hydrochloride for Oral …

Molindone

An indole derivative effective in schizophrenia and other psychoses and possibly useful in the treatment of the aggressive type of undersocialized conduct disorder. Molindone has much lower affinity for D2 receptors than most antipsychotic agents and has a relatively low affinity for D1 receptors. It has only low to moderate...
Approved
Matched Description: … An indole derivative effective in schizophrenia and other psychoses and possibly useful in the treatment ... It has only low to moderate affinity for cholinergic and alpha-adrenergic receptors. ... Molindone has much lower affinity for D2 receptors than most antipsychotic agents and has a relatively …
Matched Salts name: … Molindone hydrochloride …
Matched Products: … Molindone Hydrochloride …

Mecamylamine

A nicotinic antagonist that is well absorbed from the gastrointestinal tract and crosses the blood-brain barrier. Mecamylamine has been used as a ganglionic blocker in treating hypertension, but, like most ganglionic blockers, is more often used now as a research tool.
Approved
Investigational
Matched Description: … A nicotinic antagonist that is well absorbed from the gastrointestinal tract and crosses the blood-brain …
Matched Salts name: … Mecamylamine hydrochloride …
Matched Categories: … Secondary and Tertiary Amines …
Matched Products: … Mecamylamine Hydrochloride …

Alosetron

Alosetron is a 5-HT3 antagonist used only for the management of severe diarrhoea-predominant irritable bowel syndrome (IBS) in women. Alosetron has an antagonist action on the 5-HT3 receptors and thus may modulate serotonin-sensitive gastrointestinal (GI) processes. Alosetron was voluntarily withdrawn from the US market in November 2000 by the manufacturer...
Approved
Withdrawn
Matched Description: … reports of severe adverse effects including ischemic colitis, severely obstructed or ruptured bowel, and ... Alosetron has an antagonist action on the 5-HT3 receptors and thus may modulate serotonin-sensitive gastrointestinal …
Matched Salts name: … Alosetron hydrochloride …
Matched Categories: … Alimentary Tract and Metabolism …
Matched Products: … Alosetron Hydrochloride …

N-methylnicotinamide

N-methylnicotinamide is an experimental drug with no approved indication or marketed formulation. It is a metabolite of niacinamide/nicotinamide and niacin/nicotinic acid (vitamin B3), and as such N-methylnicotinamide is used to diagnose niacin deficiency by measuring N-methylnicotinamide in the urine.
Experimental
Matched Synonyms: … 3-(Methylcarbamoyl)pyridine ... 3-(N-Methylcarbamoyl)pyridine …
Matched Description: … It is a metabolite of niacinamide/nicotinamide and niacin/nicotinic acid (vitamin B3), and as such N-methylnicotinamide …
Matched Categories: … Bile and Liver Therapy ... Alimentary Tract and Metabolism …

Cyclopentolate

A parasympatholytic anticholinergic used solely to obtain mydriasis or cycloplegia.
Approved
Matched Salts name: … Cyclopentolate hydrochloride …
Matched Categories: … Mydriatics and Cycloplegics …
Matched Products: … Cyclopentolate Hydrochloride ... Minims Cyclopentolate Hydrochloride ... MINIMS CYCLOPENTOLATE HYDROCHLORIDE EYE DROPS 1% w/v …

Romilkimab

Romilkimab is under investigation in clinical trial NCT02345070 (Efficacy and Safety of SAR156597 in the Treatment of Idiopathic Pulmonary Fibrosis).
Investigational
Matched Synonyms: … Bispecific antibody targeting interleukin 4 (IL-4) and interleukin 13 (IL-13) …
Matched Description: … Romilkimab is under investigation in clinical trial NCT02345070 (Efficacy and Safety of SAR156597 in …

Tetracaine

Tetracaine is an ester local anaesthetic currently available in combination with lidocaine as a cream and patch.
Approved
Vet approved
Matched Description: … Tetracaine is an ester local anaesthetic currently available in combination with lidocaine as a cream and …
Matched Mixtures name: … Lidocaine and Tetracaine ... Lidocaine and Tetracaine …
Matched Salts name: … Tetracaine hydrochloride …
Matched Categories: … Antipruritics and Local Anesthetics ... Agents for Treatment of Hemorrhoids and Anal Fissures for Topical Use …
Matched Products: … Tetracaine Hydrochloride ... 0.5% TETRACAINE HYDROCHLORIDE ... Minims Tetracaine Hydrochloride …

Diamorphine

Diamorphine (heroin) is a narcotic analgesic that may be habit-forming. It is a controlled substance (opium derivative) listed in the U.S. Code of Federal Regulations, Title 21 Parts 329.1, 1308.11 (1987). Sale is forbidden in the United States by Federal statute. (Merck Index, 11th ed) Internationally, diamorphine is controlled under...
Approved
Illicit
Investigational
Matched Description: … As heroin, it is illegal to manufacture, possess, or sell in the United States and the UK. ... (Merck Index, 11th ed) Internationally, diamorphine is controlled under Schedules I and IV of the Single …
Matched Salts name: … Diamorphine hydrochloride …
Matched Products: … Diacetylmorphine Hydrochloride ... Diamorphine Hydrochloride Inj 30mg/ml BP ... Diamorphine Hydrochloride Inj 100mg/ml BP …

Carbidopa

Carbidopa presents a chemical denomination of N-amino-alpha-methyl-3-hydroxy-L-tyrosine monohydrate. It potently inhibits aromatic amino acid decarboxylase (DDC) and due to its chemical properties, it does not cross the blood-brain barrier. Due to its activity, carbidopa is always administered concomitantly with levodopa. An individual formulation containing solely carbidopa was generated to treat...
Approved
Matched Description: … It potently inhibits aromatic amino acid decarboxylase (DDC) and due to its chemical properties, it does ... approved product by the FDA containing only carbidopa was developed by Amerigens Pharmaceuticals Ltd and …
Matched Mixtures name: … Carbidopa and Levodopa ... Carbidopa and Levodopa ... Carbidopa and Levodopa …
Matched Products: … Carbidopa and Levodopa ... Carbidopa and levodopa …

DCVAC/OvCa

DCVAC/OvCa is a therapy comprising autologous dendritic cells pulsed with killed ovarian cancer cells and matured by TLR3 ligand ex vivo. It is under investigation for the treatment of ovarian cancer.
Investigational
Matched Synonyms: … Autologous dendritic cells pulsed with killed ovarian cancer cells and matured by TLR3 ligand ex vivo …
Matched Description: … DCVAC/OvCa is a therapy comprising autologous dendritic cells pulsed with killed ovarian cancer cells and …

CHF5633

CHF5633 is a fully synthetic pulmonary surfactant preparation comprising DPPC (dipalmitoylphosphatidylcholine), POPG Na (palmitoyl‐oleoyl‐phosphatidylglycerol sodium), a synthetic SP-C analogue, and a synthetic SP-B analogue.
Investigational
Matched Synonyms: … Synthetic surfactant comprised of DPPC, POPG Na, synthetic SP-C analogue and synthetic SP-B analogue …
Matched Description: … dipalmitoylphosphatidylcholine), POPG Na (palmitoyl‐oleoyl‐phosphatidylglycerol sodium), a synthetic SP-C analogue, and …
Matched Categories: … Amino Acids, Peptides, and Proteins …
Displaying drugs 101 - 125 of 650 in total