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Displaying drugs 126 - 150 of 895 in total
Axitinib is a second generation tyrosine kinase inhibitor that works by selectively inhibiting vascular endothelial growth factor receptors (VEGFR-1, VEGFR-2, VEGFR-3). Through this mechanism of action, axitinib blocks angiogenesis, tumour growth and metastases. It is reported to exhibit potency that is 50-450 times higher than that of the first generation...
Approved
Investigational
Matched Description: … endothelial growth factor receptors (VEGFR-1, VEGFR-2, VEGFR-3). ... Axitinib is a second generation tyrosine kinase inhibitor that works by selectively inhibiting vascular ... [L6676] Through this mechanism of action, axitinib blocks angiogenesis, tumour growth and metastases. …
Matched Categories: … Heterocyclic Compounds, 1-Ring ... Benzamides and benzamide derivatives ... Antineoplastic and Immunomodulating Agents ... UGT1A1 Substrates with a Narrow Therapeutic Index ... P-glycoprotein substrates with a Narrow Therapeutic Index …
Matched Products: … INLYTA (TABLETS 1 MG) ... Axitinib STADA 1 mg Filmtabletten ... INLYTA ® 1 MG TABLETA RECUBIERTA …
Cisatracurium is a non-depolarising neuromuscular blocking agent of the benzylisoquinolinium class, available in its salt form, cisatracurium besylate.[A243416,A253592] Cisatracurium has an intermediate duration of action and is one of the most commonly used neuromuscular blocking agents in intensive care.[A253592,A253597]. Cisatracurium acts on cholinergic receptors, blocking neuromuscular transmission. This action is...
Approved
Investigational
Matched Synonyms: … (1r,2r,1'r,2'r)-2,2'-{pentane-1,5-diylbis[oxy(3-oxopropane-3,1-diyl)]}bis[1-(3,4-dimethoxybenzyl)-6,7 …
Matched Iupac: … (1R,2R)-1-[(3,4-dimethoxyphenyl)methyl]-2-(3-{[5-({3-[(1R,2R)-1-[(3,4-dimethoxyphenyl)methyl]-6,7-dimethoxy …
Matched Description: … [A243416] Compared to atracurium, cisatracurium produces a lower degree of histamine release. ... Cisatracurium is a non-depolarising neuromuscular blocking agent of the benzylisoquinolinium class, available ... [A243416,A253592] Cisatracurium has an intermediate duration of action and is one of the most commonly …
Icodextrin is an iso-osmotic peritoneal dialysis solution containing glucose polymers. It is used primarily for ambulatory peritoneal dialysis (CAPD) of diabetic patients and automated peritoneal dialysis (APD) for patients with end-stage renal disease. It is injected as a solution into the peritoneal cavity. The drug is absorbed via convective transport...
Approved
Investigational
Matched Description: … It is injected as a solution into the peritoneal cavity. ... It is used primarily for ambulatory peritoneal dialysis (CAPD) of diabetic patients and automated peritoneal …
Matched Categories: … Compounds used in a research, industrial, or household setting …
Berotralstat is a selective inhibitor of plasma kallikrein used in the prophylaxis of attacks of hereditary angioedema (HAE). It works by blocking the enzymatic activity of plasma kallikrein in releasing bradykinin, the major biologic peptide that promotes swelling and pain associated with attacks of HAE. Berotralstat is strictly used to...
Approved
Matched Synonyms: … (+)-1-(3-(aminomethyl) phenyl)-N-(5-((3-cyanophenyl)(cyclopropylmethylamino)methyl)-2-fluorophenyl)-3 ... (R)-1-(3-(aminomethyl) phenyl)-N-(5-((3- cyanophenyl)(cyclopropylmethylamino)methyl)-2-fluorophenyl)- …
Matched Iupac: … 1-[3-(aminomethyl)phenyl]-N-{5-[(R)-(3-cyanophenyl)[(cyclopropylmethyl)amino]methyl]-2-fluorophenyl}- …
Matched Description: … pediatric patients 12 years and older. ... Berotralstat is a selective inhibitor of plasma kallikrein used in the prophylaxis of attacks of hereditary ... activity of plasma kallikrein in releasing bradykinin, the major biologic peptide that promotes swelling and
Matched Categories: … Blood and Blood Forming Organs ... Heterocyclic Compounds, 1-Ring …
Histrelin is a gonadotropin-releasing hormone (GnRH) agonist that acts as a potent inhibitor of gonadotropin when administered as an implant delivering continuous therapeutic doses. This drug is a synthetic analog of naturally occurring GnRH with a higher potency. Histrelin implants are non-biodegradable, diffusion-controlled, hydrogel polymer reservoirs containing histrelin acetate that...
Approved
Withdrawn
Matched Synonyms: … 5-oxo-L-prolyl-L-histidyl-L-tryptophyl-L-seryl-L-tyrosyl-1-benzyl-D-histidyl-L-leucyl-L-arginyl-N-ethyl-L-prolinamide …
Matched Iupac: … (2S)-1-[(2S)-2-[(2S)-2-[(2R)-3-(1-benzyl-1H-imidazol-4-yl)-2-[(2S)-2-[(2S)-3-hydroxy-2-[(2S)-2-[(2S)- …
Matched Description: … treatment for children with central precocious puberty (CPP) due to their capacity to reduce LH levels and ... This drug is a synthetic analog of naturally occurring GnRH with a higher potency. ... Histrelin is a gonadotropin-releasing hormone (GnRH) agonist that acts as a potent inhibitor of gonadotropin …
Matched Categories: … Hormones and Related Agents ... Amino Acids, Peptides, and Proteins ... Antineoplastic and Immunomodulating Agents ... Hormones, Hormone Substitutes, and Hormone Antagonists …
Nonoxynol-9 (N-9) is a typical surfactant used as a vaginal spermicide. Spermicides are locally acting non-hormonal contraceptives. When present in the vagina during intercourse, they immobilize/inactivate/damage and/or kill sperms without eliciting systemic effects. N-9 has been in use for more than 30 years as an over-the-counter (OTC) drug in creams,...
Approved
Withdrawn
Matched Synonyms: … 26-(Nonylphenoxy)-3,6,9,12,15,18,21,24-octaoxahexacosan-1-ol …
Matched Iupac: … 26-(4-nonylphenoxy)-3,6,9,12,15,18,21,24-octaoxahexacosan-1-ol …
Matched Description: … Nonoxynol-9 (N-9) is a typical surfactant used as a vaginal spermicide. ... It is the most commonly used spermicidal contraceptive in the UK and the USA. ... N-9 has been in use for more than 30 years as an over-the-counter (OTC) drug in creams, gels, foams and
Matched Categories: … Compounds used in a research, industrial, or household setting …
Articaine is a dental local anesthetic. Articaine is widely used around the world and is the most popular local anesthetic in many European countries.
Approved
Matched Description: … Articaine is a dental local anesthetic. ... Articaine is widely used around the world and is the most popular local anesthetic in many European countries …
Matched Mixtures name: … ULTRACAIN D-S FORTE 40 MG/ML+12 MCG/ML ENJEKSİYONLUK ÇÖZELTİ İÇEREN AMPUL ... ULTRACAIN D-S FORT 40 MG/ML+12 MCG/ML ENJEKSİYONLUK ÇÖZELTİ İÇEREN KARPÜL ... Septocaine and Epinephrine …
Matched Categories: … Heterocyclic Compounds, 1-Ring …
Alpha-dihydroergocryptine is usually referred to the mixture of the alpha and beta dihydroergocryptine. These two compounds are differentiated in the position of a methyl group. This structural difference is due to a proteinogenic amino acid replacement from leucine to isoleucine. Both compounds are hydrogenated ergot derivatives. Alpha-dihydroergocryptine approved drug product...
Approved
Matched Iupac: … diazatricyclo[7.3.0.0^{2,6}]dodecan-4-yl]-6-methyl-6,11-diazatetracyclo[7.6.1.0^{2,7}.0^{12,16}]hexadeca-1( …
Matched Description: … Alpha-dihydroergocryptine is usually referred to the mixture of the alpha and beta dihydroergocryptine ... These two compounds are differentiated in the position of a methyl group. ... Alpha-dihydroergocryptine approved drug product is as a part of an ergoloid mixture. …
Hydroxyethyl cellulose is a polysaccharide derivative with gel thickening, emulsifying, bubble-forming, water-retaining and stabilizing properties. It is used as a key ingredient in many household cleaning products, lubricants and cosmetics due to its non-ionic and water-soluble nature. It is often used as an ingredient in ophthalmic pharmaceutical preparations such as...
Approved
Matched Iupac: … 1-{[3,4,5-tris(2-hydroxypropoxy)-6-{[4,5,6-tris(2-hydroxypropoxy)-2-[(2-hydroxypropoxy)methyl]oxan-3- …
Matched Description: … It is used as a key ingredient in many household cleaning products, lubricants and cosmetics due to its ... Hydroxyethyl cellulose is a polysaccharide derivative with gel thickening, emulsifying, bubble-forming ... non-ionic and water-soluble nature. …
Matched Salts name: … Hydroxyethyl cellulose (1500 MPa.s at 1%) ... Hydroxyethyl cellulose (2000 MPa.s at 1%) ... Hydroxyethyl cellulose (3000 MPa.s at 1%) ... Hydroxyethyl cellulose (4000 MPa.s at 1%) ... Hydroxyethyl cellulose (5000 MPa.s at 1%) …
Matched Categories: … Compounds used in a research, industrial, or household setting …
Infigratinib is a pan-fibroblast growth factor receptor (FGFR) kinase inhibitor. By inhibiting the FGFR pathway, which is often aberrated in cancers such as cholangiocarcinoma, infigratinib suppresses tumour growth. Cholangiocarcinoma is the most common primary malignancy affecting the biliary tract and the second most common primary hepatic malignancy. Infitratinib is a...
Approved
Investigational
Matched Iupac: … 3-(2,6-dichloro-3,5-dimethoxyphenyl)-1-(6-{[4-(4-ethylpiperazin-1-yl)phenyl]amino}pyrimidin-4-yl)-1-methylurea …
Matched Description: … [A235174] Cholangiocarcinoma is the most common primary malignancy affecting the biliary tract and the ... Infigratinib is a pan-fibroblast growth factor receptor (FGFR) kinase inhibitor. ... [A198963] Infitratinib is a pan-FGFR inhibitor, as it is an ATP-competitive inhibitor of all four FGFR …
Matched Salts cas: … 1310746-12-3 ... 1310746-10-1
Matched Categories: … Antineoplastic and Immunomodulating Agents ... MATE 1 Inhibitors ... Heterocyclic Compounds, 1-Ring ... Receptor, Fibroblast Growth Factor, Type 1, antagonists & inhibitors …
Secnidazole is a second-generation 5-nitroimidazole antimicrobial agent. It is structurally related to other 5-nitroimidazoles, including DB00916 and DB00911, but displays improved oral absorption and a longer terminal elimination half-life than other drugs in this class. Secnidazole is selective against many anaerobic Gram-positive and Gram-negative bacteria as well as protozoa. Once...
Approved
Matched Synonyms: … 1-(2-methyl-5-nitro-1H-imidazol-1-yl) propan-2­ ol ... 1-(2­ hydroxypropyl)-2-methyl-5-nitroimidazole …
Matched Iupac: … 1-(2-methyl-5-nitro-1H-imidazol-1-yl)propan-2-ol …
Matched Description: … to form a radical anion, thereby damaging and killing the target pathogen. ... improved oral absorption and a longer terminal elimination half-life than other drugs in this class. ... Secnidazole is a second-generation 5-nitroimidazole antimicrobial agent. …
Matched Categories: … Heterocyclic Compounds, 1-Ring ... azithromycin, fluconazole and secnidazole ... Antiparasitic Products, Insecticides and Repellents …
Matched Products: … SECNICHEN POLVO PARA RECONSTITUIR A SUSPENSIÓN ORAL ... SECNIDAZOL PPS (POLVO PARA RECONSTITUIR A SUSPENSIÓN) ... SECNIPEN 750 MG POLVO PARA RECOSTRUIR A SUSPENSION ORAL …
Gemeprost is a prostaglandin E1 (PGE1) analog and antiprogestogen used for preoperative dilation of the cervix before surgical abortion. It is available as vaginal suppositories and also used in combination with the antiprogestin and mifepristone for termination of 1st- and 2nd-trimester pregnancy . It is not FDA-approved but available in...
Approved
Withdrawn
Matched Iupac: … methyl (2E)-7-[(1R,2R,3R)-3-hydroxy-2-[(1E,3R)-3-hydroxy-4,4-dimethyloct-1-en-1-yl]-5-oxocyclopentyl] …
Matched Description: … Gemeprost is a prostaglandin E1 (PGE1) analog and antiprogestogen used for preoperative dilation of the ... It is available as vaginal suppositories and also used in combination with the antiprogestin and mifepristone ... for termination of 1st- and 2nd-trimester pregnancy [A19726]. …
Matched Categories: … Genito Urinary System and Sex Hormones …
Matched Products: … CERVAGEM VAGINAL PESSARY 1 mg …
Levetiracetam is a drug within the pyrrolidine class that is used to treat various types of seizures stemming from epileptic disorders. It was first approved for use in the United States in 1999 and is structurally and mechanistically unrelated to other anti-epileptic drugs (AEDs).[L8606,L8600,L8615] Levetiracetam possesses a wide therapeutic index[L8615,A185918]...
Approved
Matched Iupac: … (2S)-2-(2-oxopyrrolidin-1-yl)butanamide …
Matched Description: … indexes and a propensity for involvement in drug interactions. ... [L8606,L8600,L8615] Levetiracetam possesses a wide therapeutic index[L8615,A185918] and little-to-no ... It was first approved for use in the United States in 1999 and is structurally and mechanistically unrelated …
Matched Categories: … Heterocyclic Compounds, 1-Ring …
Matched Products: … LEVIPIL®1 G ... LEVETIRACETAM 1A PHARM1000 ... LEVETIRACETAM 1A PHARMA250 …
Nebivolol is a racemic mixture of 2 enantiomers where one is a beta adrenergic antagonist and the other acts as a cardiac stimulant without beta adrenergic activity. Treatment with nebivolol leads to a greater decrease in systolic and diastolic blood pressure than atenolol, propranolol, or pindolol. Nebivolol and other beta...
Approved
Investigational
Matched Iupac: … 1-(6-fluoro-3,4-dihydro-2H-1-benzopyran-2-yl)-2-{[2-(6-fluoro-3,4-dihydro-2H-1-benzopyran-2-yl)-2-hydroxyethyl ... ]amino}ethan-1-ol …
Matched Description: … Nebivolol is a racemic mixture of 2 enantiomers where one is a beta adrenergic antagonist and the other ... [A182579] Treatment with nebivolol leads to a greater decrease in systolic and diastolic blood pressure ... acts as a cardiac stimulant without beta adrenergic activity. …
Matched Categories: … Adrenergic beta-1 Receptor Agonists ... Heterocyclic Compounds, 1-Ring ... valsartan and nebivolol ... nebivolol and thiazides ... nebivolol and amlodipine …
Matched Products: … Nebivolol 1A Pharma 5 mg - Tabletten …
Approved
Experimental
Matched Iupac: … 2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-3,4-dihydro-2H-1-benzopyran-6-yl acetate …
Matched Mixtures name: … .-12 ... PNV Tabs 29-1 ... Trinatal Rx 1
Apalutamide is a potent androgen receptor (AR) antagonist that selectively binds to the ligand-binding domain of AR and blocks AR nuclear translocation or binding to androgen response elements . It has been used in trials studying the treatment of Prostate Cancer, Hepatic Impairment, Prostatic Neoplasms, Castration-Resistant Prostate Cancer, and Prostatic...
Approved
Investigational
Matched Description: … In mice bearing human CRPC xenograft models, apalutamide treatment produced tumor regressions in a dose-dependent ... prostate cancer had ≥50% PSA decline at week 12 of apalutamide treatment [A31846]. ... Higher prostate-specific antigen (PSA) and shorter PSA doubling time (PSA DT) are associated with a higher …
Matched Categories: … MATE 1 Inhibitors ... Heterocyclic Compounds, 1-Ring ... Antineoplastic and Immunomodulating Agents ... Hormone Antagonists and Related Agents …
Nifedipine, or BAY a 1040, is a first generation dihydropyridine L-type calcium channel blocker, similar to nicardipine.[A190210,A190273,A175390,L11383] Nifedipine was developed by Bayer and first described in the literature, along with other dihydropyridines, in 1972.[A175390,A190276] Since nifedipine's development, second and third generation dihydropyridines have been developed with slower onsets and longer...
Approved
Matched Description: … Nifedipine, or BAY a 1040, is a first generation dihydropyridine L-type calcium channel blocker, similar ... developed with slower onsets and longer durations of action. ... [A190210,A190273,A175390,L11383] Nifedipine was developed by Bayer and first described in the literature …
Matched Categories: … Heterocyclic Compounds, 1-Ring ... atenolol and nifedipine ... nifedipine and diuretics ... Calcium Channel Blockers and Diuretics ... Calcium-Regulating Hormones and Agents …
Matched Products: … ANHITEN-A ... BECLAZONE30 MG CÁPSULAS DE LIBERACIÓN CONTROLADA 12 HORAS …
Unfractionated heparin (UH) is a heterogenous preparation of anionic, sulfated glycosaminoglycan polymers with weights ranging from 3000 to 30,000 Da. It is a naturally occurring anticoagulant released from mast cells. It binds reversibly to antithrombin III (ATIII) and greatly accelerates the rate at which ATIII inactivates coagulation enzymes thrombin (factor...
Approved
Investigational
Matched Description: … UH has a higher risk of bleeding and higher risk of osteoporosis in long term use. ... It is a naturally occurring anticoagulant released from mast cells. ... coagulation enzymes thrombin (factor IIa) and factor Xa. …
Matched Mixtures name: … BARICUS 50 IU/%1/%10 JEL , 50 G ... Heparin Sod and 0.9% Sod Chloride Inj ... Heparin Sodium and Dextrose 5% Inj USP …
Matched Categories: … Heparin and similars ... Blood and Blood Forming Organs …
Matched Products: … Heparin Sodium and Dextrose ... Heparin Sodium and Sodium Chloride ... BİEMPARİN 25000 IU/5ML IV ENJEKSİYONLUK ÇÖZELTİ İÇEREN FLAKON (1 FLAKON), 1 ADET …
Caffeine is a drug of the methylxanthine class used for a variety of purposes, including certain respiratory conditions of the premature newborn, pain relief, and to combat drowsiness. Caffeine is similar in chemical structure to Theophylline and Theobromine.[A187691,L9851] It can be sourced from coffee beans, but also occurs naturally in...
Approved
Matched Synonyms: … 1-methyltheobromine …
Matched Description: … This correlates to about 1 in 10 births. ... [T716] Caffeine is also used in a variety of cosmetic products and can be administered topically, orally ... Premature birth can lead to apnea and bronchopulmonary dysplasia, a condition that interferes with lung …
Matched Mixtures name: … Pancold A ... Saridon - A ... Ac and C Tab 1/8gr …
Matched Categories: … caffeine and sodium benzoate ... Respiratory and CNS Stimulants ... Caffeine and Caffeine Containing Products ... Anorexigenic Agents & Respiratory and CNS Stimulants ... Psychostimulants, Agents Used for ADHD and Nootropics …
Matched Products: … Caffeine and Sodium Benzoate ... KAFESIT 20 MG/ML IV ENJEKSIYON ICIN COZELTI ICEREN FLAKON, 1 ADET …
A carbamate with hypnotic, sedative, and some muscle relaxant properties, although in therapeutic doses reduction of anxiety rather than a direct effect may be responsible for muscle relaxation. Meprobamate has been reported to have anticonvulsant actions against petit mal seizures, but not against grand mal seizures (which may be exacerbated)....
Approved
Illicit
Matched Description: … A carbamate with hypnotic, sedative, and some muscle relaxant properties, although in therapeutic doses ... It is used in the treatment of anxiety disorders, and also for the short-term management of insomnia ... reduction of anxiety rather than a direct effect may be responsible for muscle relaxation. …
Matched Categories: … Hypnotics and Sedatives …
Dexbrompheniramine maleate is an antihistamine agent that is used for the treatment of allergic conditions, such as hay fever or urticaria.
Approved
Matched Synonyms: … 3-(4-bromophenyl)- N,N-dimethyl- 3-pyridin-2-yl-propan-1-amine …
Matched Mixtures name: … Supress A ... AFRINEX EFX 12 ... Coricidin 'd' Nasal and Sinus Congestion …
Matched Categories: … Heterocyclic Compounds, 1-Ring …
Cyanocobalamin Co-60 is an analog of Vitamin B12 labeled with Co60. Cyanocobalamin Co-60 was used for the diagnosis of pernicious anemia, but now it is withdrawn from the market in the US for unknown reasons.
Approved
Withdrawn
Matched Iupac: … {7,10}.1^{12,15}]tricosa-5(23),6,10(22),11,15(21),16-hexaen-20-ide iminomethanide ... propyl]carbamoyl}ethyl)-2,3,6,8,13,13,16,18-octamethyl-20,21,22,23-tetraazapentacyclo[15.2.1.1^{2,5}.1^ ... carbamoylethyl)-3,8,19-tris(carbamoylmethyl)-18-(2-{[(2R)-2-{[(2R,3S,4R,5S)-5-(5,6-dimethyl-1H-1,3-benzodiazol-1- …
Duchenne muscular dystrophy (DMD) is an X-linked recessive allelic disorder characterized by a lack of functional dystrophin protein, which leads to progressive ambulatory, pulmonary, and cardiac function and is invariably fatal. A related, albeit a less severe, form of muscular dystrophy known as Becker muscular dystrophy (BMD) is characterized by...
Approved
Investigational
Matched Description: … [A218176] Viltolarsen was granted accelerated FDA approval on August 12, 2020, based on data showing ... the five-membered ribofuranosyl ring is replaced with a six-membered morpholino ring, and the phosphodiester ... A related, albeit a less severe, form of muscular dystrophy known as Becker muscular dystrophy (BMD) …
Matched Categories: … Nucleic Acids, Nucleotides, and Nucleosides …
Diamorphine (heroin) is a narcotic analgesic that may be habit-forming. It is a controlled substance (opium derivative) listed in the U.S. Code of Federal Regulations, Title 21 Parts 329.1, 1308.11 (1987). Sale is forbidden in the United States by Federal statute. (Merck Index, 11th ed) Internationally, diamorphine is controlled under...
Approved
Illicit
Investigational
Matched Iupac: … (1S,5R,13R,14S,17R)-10-(acetyloxy)-4-methyl-12-oxa-4-azapentacyclo[9.6.1.0^{1,13}.0^{5,17}.0^{7,18}]octadeca …
Matched Description: … As heroin, it is illegal to manufacture, possess, or sell in the United States and the UK. ... It is a controlled substance (opium derivative) listed in the U.S. ... Diamorphine (heroin) is a narcotic analgesic that may be habit-forming. …
A synthetic anti-inflammatory glucocorticoid derived from cortisone. It is biologically inert and converted to prednisolone in the liver. Prednisone was granted FDA approval on 21 February 1955.
Approved
Vet approved
Matched Iupac: … ,9bH,10H,11H,11aH-cyclopenta[a]phenanthrene-7,10-dione ... (1R,3aS,3bS,9aR,9bS,11aS)-1-hydroxy-1-(2-hydroxyacetyl)-9a,11a-dimethyl-1H,2H,3H,3aH,3bH,4H,5H,7H,9aH …
Matched Description: … A synthetic anti-inflammatory glucocorticoid derived from [cortisone]. ... [A187463] It is biologically inert and converted to [prednisolone] in the liver. …
Matched Categories: … Alimentary Tract and Metabolism ... Prednisolone and Prodrugs ... Sex Hormones and Insulins ... Hormones, Hormone Substitutes, and Hormone Antagonists …
Matched Products: … ROMEZON DR 1 MG TABLET, 30 ADET ... LODOTRA® 1 MG TABLETAS DE CRONO LIBERACION MODIFICADA …
Displaying drugs 126 - 150 of 895 in total