Identification

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Name
Prednisone
Accession Number
DB00635  (APRD00340)
Type
Small Molecule
Groups
Approved, Vet approved
Description

A synthetic anti-inflammatory glucocorticoid derived from cortisone.1 It is biologically inert and converted to prednisolone in the liver.9

Prednisone was granted FDA approval on 21 February 1955.8

Structure
Thumb
Synonyms
  • 1,2-Dehydrocortisone
  • 1,4-Pregnadiene-17α,21-diol-3,11,20-trione
  • 17,21-Dihydroxypregna-1,4-diene-3,11,20-trione
  • Dehydrocortisone
  • Prednisona
  • Prednisone
  • Prednisonum
External IDs
NSC-10023
Active Moieties
NameKindUNIICASInChI Key
Prednisoloneprodrug9PHQ9Y1OLM50-24-8OIGNJSKKLXVSLS-VWUMJDOOSA-N
Product Images
Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
DeltasoneTablet50 mg/1OralPharmacia and Upjohn and Company2007-03-30Not applicableUs
DeltasoneTablet2.5 mg/1OralPharmacia and Upjohn and Company2007-03-30Not applicableUs
DeltasoneTablet5 mg/1OralPhysicians Total Care, Inc.1992-12-012011-05-31Us
DeltasoneTablet20 mg/1OralPharmacia and Upjohn and Company2007-03-30Not applicableUs
DeltasoneTablet10 mg/1OralPharmacia and Upjohn and Company2007-03-30Not applicableUs
DeltasoneTablet5 mg/1OralPharmacia and Upjohn and Company2007-03-30Not applicableUs
Deltasone 50mgTabletOralPharmacia & Upjohn Inc1972-12-312000-08-02Canada
Deltasone 5mgTabletOralPharmacia & Upjohn Inc1972-12-312000-08-02Canada
Jaa Prednisone Tab 1mg USPTabletOralJaapharm Canada Inc.1993-05-152002-04-02Canada
Jaa Prednisone Tab 50mg USPTabletOralJaapharm Canada Inc.1993-12-312002-04-02Canada
Additional Data Available
  • Application Number
    Application Number

    A unique ID assigned by the FDA when a product is submitted for approval by the labeller.

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  • Product Code
    Product Code

    A governmentally-recognized ID which uniquely identifies the product within its regulatory market.

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Generic Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Alti-prednisone Tab 5mgTabletOralAltimed Pharma Inc.1984-12-311998-08-10Canada
Apo Prednisone Tab 1mg USPTabletOralApotex Corporation1984-12-31Not applicableCanada
Apo Prednisone Tab 50mgTabletOralApotex Corporation1982-12-31Not applicableCanada
Apo Prednisone Tab 5mgTabletOralApotex Corporation1982-12-31Not applicableCanada
DeltasoneTablet20 mg/1OralSonoma Pharmaceuticals, Inc.2003-02-13Not applicableUs
DeltasoneTablet20 mg/20mgOralOculus Innovative Scicences2009-08-03Not applicableUs
Perrigo PrednisoneTablet5 mg/1OralPerrigo International2006-05-192010-11-01Us
Perrigo PrednisoneTablet20 mg/1OralPerrigo International2006-10-112011-02-04Us
Perrigo PrednisoneTablet10 mg/1OralPerrigo International2006-05-192010-11-01Us
PrednisoneTablet5 mg/1OralDispensing Solutions, Inc.2008-05-29Not applicableUs68258 301320180907 15195 57efwu
Additional Data Available
  • Application Number
    Application Number

    A unique ID assigned by the FDA when a product is submitted for approval by the labeller.

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  • Product Code
    Product Code

    A governmentally-recognized ID which uniquely identifies the product within its regulatory market.

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Mixture Products
NameIngredientsDosageRouteLabellerMarketing StartMarketing End
Metreton TabPrednisone (2.5 mg) + Ascorbic acid (75 mg) + Chlorpheniramine maleate (2 mg)TabletOralSchering Plough1956-12-312007-08-03Canada
PrednisonePrednisone (5 mg/5mL) + Ethanol (5 mL/100mL)SolutionOralRoxane Laboratories2006-06-272006-09-01Us
Unapproved/Other Products
NameIngredientsDosageRouteLabellerMarketing StartMarketing End
Contrast Allergy PreMed PackPrednisone (50 mg/50mg) + Diphenhydramine hydrochloride (50 mg/50mg)KitOralShertech Laboratories, Llc2016-09-13Not applicableUs
International/Other Brands
Delta-Cortef (Upjohn) / Meticorten / Orasone
Categories
UNII
VB0R961HZT
CAS number
53-03-2
Weight
Average: 358.4281
Monoisotopic: 358.178023942
Chemical Formula
C21H26O5
InChI Key
XOFYZVNMUHMLCC-ZPOLXVRWSA-N
InChI
InChI=1S/C21H26O5/c1-19-7-5-13(23)9-12(19)3-4-14-15-6-8-21(26,17(25)11-22)20(15,2)10-16(24)18(14)19/h5,7,9,14-15,18,22,26H,3-4,6,8,10-11H2,1-2H3/t14-,15-,18+,19-,20-,21-/m0/s1
IUPAC Name
(1S,2R,10S,11S,14R,15S)-14-hydroxy-14-(2-hydroxyacetyl)-2,15-dimethyltetracyclo[8.7.0.0²,⁷.0¹¹,¹⁵]heptadeca-3,6-diene-5,17-dione
SMILES
[H][C@@]12CC[C@](O)(C(=O)CO)[C@@]1(C)CC(=O)[C@@]1([H])[C@@]2([H])CCC2=CC(=O)C=C[C@]12C

Pharmacology

Indication

Prednisone is indicated as an anti-inflammatory or immunosuppressive drug for allergic, dermatologic, gastrointestinal, hematologic, ophthalmologic, nervous system, renal, respiratory, rheumatologic, infectious, endocrine, or neoplastic conditions as well as in organ transplant.9

Associated Conditions
Pharmacodynamics

Corticosteroids bind to the glucocorticoid receptor, inhibiting pro-inflammatory signals, and promoting anti-inflammatory signals.1 Prednisone has a short duration of action as the half life is 2-3 hours.9 Corticosteroids have a wide therapeutic window as patients make require doses that are multiples of what the body naturally produces.1 Patients taking corticosteroids should be counselled regarding the risk of hypothalamic-pituitary-adrenal axis suppression and increased susceptibility to infections.1

Mechanism of action

Prednisone is first metabolized in the liver to its active form, prednisolone, a glucocorticoid agonist corticosteroid.9

The short term effects of corticosteroids are decreased vasodilation and permeability of capillaries, as well as decreased leukocyte migration to sites of inflammation.1 Corticosteroids binding to the glucocorticoid receptor mediates changes in gene expression that lead to multiple downstream effects over hours to days.1

Glucocorticoids inhibit neutrophil apoptosis and demargination; they inhibit phospholipase A2, which decreases the formation of arachidonic acid derivatives; they inhibit NF-Kappa B and other inflammatory transcription factors; they promote anti-inflammatory genes like interleukin-10.1

Lower doses of corticosteroids provide an anti-inflammatory effect, while higher doses are immunosuppressive.1 High doses of glucocorticoids for an extended period bind to the mineralocorticoid receptor, raising sodium levels and decreasing potassium levels.1

TargetActionsOrganism
AGlucocorticoid receptor
agonist
Humans
Additional Data Available
Adverse Effects

Comprehensive structured data on known drug adverse effects with statistical prevalence. MedDRA and ICD10 ids are provided for adverse effect conditions and symptoms.

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Additional Data Available
Contraindications

Structured data covering drug contraindications. Each contraindication describes a scenario in which the drug is not to be used. Includes restrictions on co-administration, contraindicated populations, and more.

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Additional Data Available
Blackbox Warnings

Structured data representing warnings from the black box section of drug labels. These warnings cover important and dangerous risks, contraindications, or adverse effects.

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Absorption

Oral prednisone has a Tmax of 2 hours, while the delayed-release formulation has a Tmax of 6-6.5 hours.9 A 5mg dose of prednisone has an AUC of 572mL/min/1.73m2, a 20mg dose of prednisone has an AUC of 1034mL/min/1.73m2, and a 50mg dose of prednisone has an AUC of 2271mL/min/1.73m2.5 Data regarding the Cmax of prednisone is not readily available.9

Volume of distribution

Data regarding the volume of distribution for prednisone is not readily available.9 However, a 0.15mg/kg dose of prednisolone has a volume of distribution of 29.3L, while a 0.30mg/kg dose has a volume of distribution of 44.2L.6

Protein binding

Corticosteroids are generally bound to corticosteroid binding globulin7 and serum albumin2 in plasma. Prednisone is <50% bound to protein in plasma.3

Metabolism

Prednisone is metabolized to 17α,21-dihydroxy-pregnan-1,4,6-trien-3,11,30-trione (M-XVII), 20α-dihydro-prednisone (M-V), 6βhydroxy-prednisone (M-XII), 6α-hydroxy-prednisone (M-XIII), or 20β-dihydro-prednisone (M-IV).4 20β-dihydro-prednisone is metabolized to 17α,20ξ,21-trihydroxy-5ξ-pregn-1-en-3,11-dione(M-XVIII).4 Prednison is reversibly metabolized to prednisolone.4 Prednisolone is metabolized to Δ6-prednisolone (M-XI), 20α-dihydro-prednisolone (M-III), 20β-dihydro-prednisolone (M-II), 6αhydroxy-prednisolone (M-VII), or 6βhydroxy-prednisolone(M-VI).4 6αhydroxy-prednisolone is metabolized to 6α,11β,17α,20β,21-pentahydroxypregnan-1,4-diene-3-one (M-X).4 6βhydroxy-prednisolone is metabolized to 6β,11β,17α,20β,21-pentahydroxypregnan-1,4-diene-3-one (M-VIII), 6β,11β,17α,20α,21-pentahydroxypregnan-1,4-diene-3-one (M-IX), and 6β,11β,17α,21-tetrahydroxy-5ξ-pregn-1-en-3,20-dione (M-XIV).4 MVIII is metabolized to 6β,11β,17α,20β,21-pentahydroxy-5ξ-pregn-1-en-3-one (M-XV) and then to MXIV, while MIX is metabolized to 6β,11β,17α,20α,21-pentahydroxy-5ξ-pregn-1-en-3-one (M-XVI) and then to MXIV.4 These metabolites and their glucuronide conjugates are excreted predominantly in the urine.4

Route of elimination

Prednisone is excreted mainly in the urine as sulfate and glucuronide conjugates.9

Half life

Prednisone and its active metabolite prednisolone have half lives of 2-3 hours from both immediate and delayed release preparations.9

Clearance

Data regarding the clearance of prednisone is not readily available.9

A 5.5µg/h/kg infusion of prednisolone has an average clearance of 0.066±0.12L/h/kg, while a 0.15±0.03L/h/kg infusion has an average clearance of 0.15L/h/kg.3

Toxicity

Data regarding acute overdoses of prednisone are rare but prolonged high doses of prednisone can lead to a higher incidence and severity of adverse effects such as mental symptoms, moon face, abnormal fat deposits, fluid retention, excessive appetite, weight gain, hypertrichosis, acne, striae, ecchymosis, increased sweating, pigmentation, dry scaly skin, thinning scalp hair, increased blood pressure, tachycardia, thrombophlebitis, decreased resistance to infection, negative nitrogen balance with delayed bone and wound healing, headache, weakness, menstrual disorders, accentuated menopausal symptoms, neuropathy, fractures, osteoporosis, peptic ulcer, decreased glucose tolerance, hypokalemia, and adrenal insufficiency.9

Affected organisms
  • Humans and other mammals
Pathways
PathwayCategory
Prednisone Action PathwayDrug action
Prednisone Metabolism PathwayDrug metabolism
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
DrugInteraction
(R)-warfarinThe metabolism of (R)-warfarin can be increased when combined with Prednisone.
(S)-WarfarinThe metabolism of (S)-Warfarin can be increased when combined with Prednisone.
1-TestosteroneThe risk or severity of edema formation can be increased when 1-Testosterone is combined with Prednisone.
1,10-PhenanthrolineThe therapeutic efficacy of 1,10-Phenanthroline can be decreased when used in combination with Prednisone.
16-BromoepiandrosteroneThe risk or severity of edema formation can be increased when 16-Bromoepiandrosterone is combined with Prednisone.
19-norandrostenedioneThe risk or severity of edema formation can be increased when 19-norandrostenedione is combined with Prednisone.
1alpha-Hydroxyvitamin D5The therapeutic efficacy of 1alpha-Hydroxyvitamin D5 can be decreased when used in combination with Prednisone.
1alpha,24S-Dihydroxyvitamin D2The therapeutic efficacy of 1alpha,24S-Dihydroxyvitamin D2 can be decreased when used in combination with Prednisone.
2-MethoxyethanolThe risk or severity of adverse effects can be increased when Prednisone is combined with 2-Methoxyethanol.
2,4-thiazolidinedioneThe risk or severity of hyperglycemia can be increased when Prednisone is combined with 2,4-thiazolidinedione.
Additional Data Available
  • Extended Description
    Extended Description

    Extended description of the mechanism of action and particular properties of each drug interaction.

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  • Severity
    Severity

    A severity rating for each drug interaction, from minor to major.

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  • Evidence Level
    Evidence Level

    A rating for the strength of the evidence supporting each drug interaction.

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  • Action
    Action

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Food Interactions
  • Avoid alcohol.
  • Avoid taking with grapefruit juice.
  • Take with food to reduce irritation.
  • When Rayos, the delayed-release tablet, is taken without food, Cmax and bioavailability were lower compared to the fed state.

References

Synthesis Reference

Jean Buendia, Michel Vivat, "Process for the production of prednisone 17.21-diacylates." U.S. Patent US4601854, issued May, 1982.

US4601854
General References
  1. Yasir M, Sonthalia S: Corticosteroid Adverse Effects . [PubMed:30285357]
  2. Czock D, Keller F, Rasche FM, Haussler U: Pharmacokinetics and pharmacodynamics of systemically administered glucocorticoids. Clin Pharmacokinet. 2005;44(1):61-98. doi: 10.2165/00003088-200544010-00003. [PubMed:15634032]
  3. Frey BM, Frey FJ: Clinical pharmacokinetics of prednisone and prednisolone. Clin Pharmacokinet. 1990 Aug;19(2):126-46. doi: 10.2165/00003088-199019020-00003. [PubMed:2199128]
  4. Matabosch X, Pozo OJ, Perez-Mana C, Papaseit E, Segura J, Ventura R: Detection and characterization of prednisolone metabolites in human urine by LC-MS/MS. J Mass Spectrom. 2015 Mar;50(3):633-42. doi: 10.1002/jms.3571. [PubMed:25800201]
  5. Rose JQ, Yurchak AM, Jusko WJ: Dose dependent pharmacokinetics of prednisone and prednisolone in man. J Pharmacokinet Biopharm. 1981 Aug;9(4):389-417. doi: 10.1007/bf01060885. [PubMed:7310640]
  6. Pickup ME: Clinical pharmacokinetics of prednisone and prednisolone. Clin Pharmacokinet. 1979 Mar-Apr;4(2):111-28. doi: 10.2165/00003088-197904020-00004. [PubMed:378499]
  7. Gardill BR, Vogl MR, Lin HY, Hammond GL, Muller YA: Corticosteroid-binding globulin: structure-function implications from species differences. PLoS One. 2012;7(12):e52759. doi: 10.1371/journal.pone.0052759. Epub 2012 Dec 26. [PubMed:23300763]
  8. FDA Approved Drug Products: Meticorten Prednisone Oral Tablets (Discontinued) [Link]
  9. FDA Approved Drug Products: Rayos Prednisone Delayed-Release Oral Tablets [Link]
External Links
Human Metabolome Database
HMDB0014773
KEGG Drug
D00473
KEGG Compound
C07370
PubChem Compound
5865
PubChem Substance
46508166
ChemSpider
5656
ChEBI
8382
ChEMBL
CHEMBL635
Therapeutic Targets Database
DAP001041
PharmGKB
PA451100
HET
PDN
RxList
RxList Drug Page
Drugs.com
Drugs.com Drug Page
Wikipedia
Prednisone
ATC Codes
A07EA03 — PrednisoneH02AB07 — Prednisone
AHFS Codes
  • 68:04.00 — Adrenals
MSDS
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Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount
0CompletedBasic ScienceAtherosclerosis / Diabetes Mellitus (DM) / Dyslipidemias1
0CompletedBasic ScienceDiabetes Mellitus (DM) / Hyperglycemia Steroid-induced1
0CompletedTreatmentLymphoma, Large B-Cell, Diffuse (DLBCL) / Post Transplant Lymphoproliferative Disorder / Primary Mediastinal (Thymic) Large B-cell Lymphoma1
0CompletedTreatmentNonneoplastic Condition1
0Not Yet RecruitingDiagnosticClinical Stage 0 Cutaneous Melanoma AJCC v8 / Clinical Stage I Cutaneous Melanoma AJCC v8 / Clinical Stage IA Cutaneous Melanoma AJCC v8 / Clinical Stage IB Cutaneous Melanoma AJCC v8 / Clinical Stage II Cutaneous Melanoma AJCC v8 / Clinical Stage IIA Cutaneous Melanoma AJCC v8 / Clinical Stage IIB Cutaneous Melanoma AJCC v8 / Clinical Stage IIC Cutaneous Melanoma AJCC v8 / Clinical Stage III Cutaneous Melanoma AJCC v8 / Clinical Stage IV Cutaneous Melanoma AJCC v8 / Colitis / Diarrhea / Malignant Genitourinary System Neoplasm / Pathologic Stage 0 Cutaneous Melanoma AJCC v8 / Pathologic Stage I Cutaneous Melanoma AJCC v8 / Pathologic Stage IA Cutaneous Melanoma AJCC v8 / Pathologic Stage IB Cutaneous Melanoma AJCC v8 / Pathologic Stage II Cutaneous Melanoma AJCC v8 / Pathologic Stage IIA Cutaneous Melanoma AJCC v8 / Pathologic Stage IIB Cutaneous Melanoma AJCC v8 / Pathologic Stage IIC Cutaneous Melanoma AJCC v8 / Pathologic Stage III Cutaneous Melanoma AJCC v8 / Pathologic Stage IIIA Cutaneous Melanoma AJCC v8 / Pathologic Stage IIIB Cutaneous Melanoma AJCC v8 / Pathologic Stage IIIC Cutaneous Melanoma AJCC v8 / Pathologic Stage IIID Cutaneous Melanoma AJCC v8 / Pathologic Stage IV Cutaneous Melanoma AJCC v81
0Not Yet RecruitingTreatmentAnn Arbor Stage I Diffuse Large B-Cell Lymphoma / Ann Arbor Stage II Diffuse Large B-Cell Lymphoma / Ann Arbor Stage III Diffuse Large B-Cell Lymphoma / Ann Arbor Stage IV Diffuse Large B-Cell Lymphoma / Plasmablastic Lymphoma1
0Not Yet RecruitingTreatmentChronic Graft Versus Host Disease1
0RecruitingTreatmentAdenocarcinoma of the Prostate / Advanced Prostate Cancer / Prostate Cancer / Stage IV Prostate Cancer1
0RecruitingTreatmentAdvanced B-cell Lymphoid Malignancies1
0RecruitingTreatmentNK-Cell Leukemia / NK-Cell Lymphoma / Peripheral T Cell Lymphoma (PTCL)1
1Active Not RecruitingOtherGlucocorticoids Toxicity / Impaired Glucose Tolerance1
1Active Not RecruitingTreatmentAIDS Related Non-Hodgkin Lymphoma / AIDS-Related Burkitt Lymphoma / AIDS-Related Diffuse Large B-cell Lymphoma / AIDS-Related Plasmablastic Lymphoma / AIDS-Related Primary Effusion Lymphoma / Human Immunodeficiency Virus (HIV) Infections1
1Active Not RecruitingTreatmentCongenital Hypoplastic Anemia1
1Active Not RecruitingTreatmentFollicular Lymphoma (FL) / Lymphoma, Large B-Cell, Diffuse (DLBCL)1
1Active Not RecruitingTreatmentHigh Grade B-cell Lymphoma / Lymphoma, Large B-Cell, Diffuse (DLBCL)1
1Active Not RecruitingTreatmentLung Cancers / Metastatic Cancers1
1Active Not RecruitingTreatmentMetastatic Castration Resistant Prostate Cancer / Metastatic Castration-Resistant Prostate Cancer (mCRPC) / Prostatic Neoplasms1
1Active Not RecruitingTreatmentMultiple Myeloma (MM)1
1Active Not RecruitingTreatmentProstate Cancer1
1CompletedNot AvailableHealthy Adults1
1CompletedNot AvailableHealthy Volunteers / Pharmacokinetics of Isavuconazole / Pharmacokinetics of Prednisolone1
1CompletedNot AvailableHuman Immunodeficiency Virus (HIV) Infections1
1CompletedBasic ScienceHealthy Volunteers3
1CompletedDiagnosticAllergic Rhinitis (AR)1
1CompletedDiagnosticAsthma1
1CompletedOtherProstate Cancer1
1CompletedSupportive CareChronic Myeloproliferative Disorders / Graft Versus Host Disease (GVHD) / Leukemias / Malignant Lymphomas / Multiple Myeloma and Plasma Cell Neoplasm / Myelodysplastic Syndromes / Precancerous/Nonmalignant Condition1
1CompletedTreatmentAcute Lymphoblastic Leukaemias (ALL)1
1CompletedTreatmentAsthma2
1CompletedTreatmentCancer, Advanced1
1CompletedTreatmentChronic Myeloproliferative Disorders / Leukemias / Malignant Lymphomas / Multiple Myeloma and Plasma Cell Neoplasm / Myelodysplastic Syndromes / Myelodysplastic/Myeloproliferative Neoplasms1
1CompletedTreatmentComposite Lymphoma / Grade 3b Follicular Lymphoma / Stage I Diffuse Large B-Cell Lymphoma / Stage I Follicular Lymphoma / Stage II Diffuse Large B-Cell Lymphoma / Stage II Follicular Lymphoma / Stage III Diffuse Large B-Cell Lymphoma / Stage III Follicular Lymphoma / Stage IV Diffuse Large B-Cell Lymphoma / Stage IV Follicular Lymphoma1
1CompletedTreatmentDisseminated Sclerosis1
1CompletedTreatmentDrug Drug Interaction (DDI)1
1CompletedTreatmentGraft Versus Host Disease, Acute / Graft-versus-host Disease (GVHD)1
1CompletedTreatmentHealthy Volunteers3
1CompletedTreatmentLeukemias / Malignant Lymphomas1
1CompletedTreatmentLeukemias / Malignant Lymphomas / Multiple Myeloma and Plasma Cell Neoplasm / Myelodysplastic Syndromes1
1CompletedTreatmentLymphoma, B-Cell1
1CompletedTreatmentLymphoma, Large-Cell, Anaplastic / Lymphoma, NK-cell / T-Cell Lymphomas1
1CompletedTreatmentMalignant Lymphomas2
1CompletedTreatmentMalignant Lymphomas / Neoplasms / Neoplasms Metastasis1
1CompletedTreatmentMalignant Lymphomas / Unspecified Adult Solid Tumor, Protocol Specific1
1CompletedTreatmentMetastatic Castration Resistant Prostate Cancer1
1CompletedTreatmentNeoplasms1
1CompletedTreatmentNon-Hodgkin's Lymphoma (NHL)2
1CompletedTreatmentPeripheral T-Cell Lymphoma (PTCL)2
1CompletedTreatmentProstate Cancer2
1CompletedTreatmentProstate Neoplasms2
1CompletedTreatmentProstatic Neoplasms1
1CompletedTreatmentRheumatoid Arthritis1
1CompletedTreatmentStatus Asthmaticus1
1Not Yet RecruitingTreatmentB-cell Acute Lymphoblastic Leukemia1
1RecruitingBasic ScienceInfections, Respiratory Syncytial Virus1
1RecruitingPreventionEsophageal Anastomotic Stricture1
1RecruitingTreatmentAcute Leukemias of Ambiguous Lineage / B-cell Adult Acute Lymphoblastic Leukemia / Philadelphia Chromosome Positive Adult Precursor Acute Lymphoblastic Leukemia / Recurrent Adult Acute Lymphoblastic Leukemia / Recurrent Adult Burkitt Lymphoma1
1RecruitingTreatmentAnn Arbor Stage II Diffuse Large B-Cell Lymphoma / Ann Arbor Stage III Diffuse Large B-Cell Lymphoma / Ann Arbor Stage IV Diffuse Large B-Cell Lymphoma / CD20 Negative / CD20 Positive / HIV Positivity / Human Immunodeficiency Virus Positive / Lymphoma, AIDS Related / Stage II Diffuse Large B-Cell Lymphoma / Stage III Diffuse Large B-Cell Lymphoma / Stage IV Diffuse Large B-Cell Lymphoma1
1RecruitingTreatmentB-cell Acute Lymphoblastic Leukemia / Chronic Myeloid Leukemia (CML) in Lymphoid Blast Crisis / Philadelphia Chromosome Positive Acute Lymphoblastic Leukemia Ph+ ALL1
1RecruitingTreatmentBlasts 5 Percent or More of Bone Marrow Nucleated Cells / Blasts 5 Percent or More of Peripheral Blood White Cells / CD22 Positive / Recurrent B Acute Lymphoblastic Leukemia / Recurrent B Lymphoblastic Lymphoma / Refractory B Acute Lymphoblastic Leukemia / Refractory B Lymphoblastic Lymphoma1
1RecruitingTreatmentBreast Cancer / Prostate Cancer1
1RecruitingTreatmentBurkitt's Lymphoma / Castleman's Disease, Multicentric / CD20 Positive / HHV8-Positive Multicentric Castleman Disease / Kaposi s Sarcoma (KS) / KSHV-associated Multicentric Castleman Disease / Lymphoma, Large B-Cell, Diffuse (DLBCL)1
1RecruitingTreatmentBurkitt's Lymphoma / Lymphoma, Large B-Cell, Diffuse (DLBCL) / Malignant Lymphomas / Non-Hodgkin's Lymphoma (NHL)1
1RecruitingTreatmentClinical Stage III Cutaneous Melanoma AJCC v8 / Clinical Stage III Merkel Cell Carcinoma AJCC v8 / Clinical Stage IV Cutaneous Melanoma AJCC v8 / Clinical Stage IV Merkel Cell Carcinoma AJCC v8 / High-Frequency Microsatellite Instability / Metastatic Basal cell carcinoma / Metastatic Melanoma / Metastatic Merkel Cell Carcinoma / Metastatic Skin Squamous Cell Carcinoma / Pathologic Stage III Cutaneous Melanoma AJCC v8 / Pathologic Stage III Merkel Cell Carcinoma AJCC v8 / Pathologic Stage IIIA Cutaneous Melanoma AJCC v8 / Pathologic Stage IIIA Merkel Cell Carcinoma AJCC v8 / Pathologic Stage IIIB Cutaneous Melanoma AJCC v8 / Pathologic Stage IIIB Merkel Cell Carcinoma AJCC v8 / Pathologic Stage IIIC Cutaneous Melanoma AJCC v8 / Pathologic Stage IIID Cutaneous Melanoma AJCC v8 / Pathologic Stage IV Cutaneous Melanoma AJCC v8 / Pathologic Stage IV Merkel Cell Carcinoma AJCC v8 / Renal Transplant Recipient Patients / Unresectable Basal Cell Carcinoma / Unresectable Melanoma / Unresectable Merkel Cell Carcinoma1
1RecruitingTreatmentDiffuse Large B-Cell Lymphoma Activated B-Cell Type / Diffuse Large B-Cell Lymphoma Germinal Center B-Cell Type / Diffuse Large B-Cell Lymphoma, Not Otherwise Specified / High Grade B-Cell Lymphoma With MYC and BCL2 and/or BCL6 Rearrangements / High Grade B-Cell Lymphoma, Not Otherwise Specified / Lymphoma, Large B-Cell, Diffuse (DLBCL) / T-Cell/Histiocyte-Rich Large B-Cell Lymphoma1
1RecruitingTreatmentFollicular Lymphoma (FL) / Lymphoma, B-Cell / Non-Hodgkin's Lymphoma (NHL)1
1RecruitingTreatmentLymphoma, B-Cell1
1RecruitingTreatmentMetastatic Castration Resistant Prostate Cancer / Prostatic Neoplasms1
1RecruitingTreatmentMetastatic Hormone Refractory Prostate Cancer1
1RecruitingTreatmentProstate Cancer1
1RecruitingTreatmentRenal Transplant Recipient Patients / Transplantation, Kidney / Transplantation, Renal1
1RecruitingTreatmentSarcoidosis / Sarcoidosis Lung / Sarcoidosis, Pulmonary1
1RecruitingTreatmentTumors, Solid1
1TerminatedTreatmentAcute Lymphoblastic Leukaemias (ALL) / Leukemia, Lymphoblastic, Acute, T Cell / Lymphoblastic Leukemia, Acute, Childhood1
1TerminatedTreatmentBurkitt's Lymphoma / Follicular Lymphoma (FL) / Lymphoma, Large B-Cell, Diffuse (DLBCL)1
1TerminatedTreatmentProstate Cancer1
1TerminatedTreatmentProstate Cancer / Prostate Cancer Metastatic Disease / Urologic Neoplasms1
1TerminatedTreatmentTransplantation, Liver1
1Unknown StatusTreatmentProstate Cancer1
1WithdrawnTreatmentAcute Lymphoblastic Leukaemias (ALL)1
1WithdrawnTreatmentLymphoma, Large B-Cell, Diffuse (DLBCL)1
1WithdrawnTreatmentMalignancies1
1WithdrawnTreatmentProstate Cancer1
1, 2Active Not RecruitingTreatmentAIDS-Related Diffuse Large Cell Lymphoma / AIDS-Related Plasmablastic Lymphoma / AIDS-Related Primary Effusion Lymphoma / Ann Arbor Stage I Diffuse Large B-Cell Lymphoma / Ann Arbor Stage I Grade 3 Follicular Lymphoma / Ann Arbor Stage II Diffuse Large B-Cell Lymphoma / Ann Arbor Stage II Grade 3 Contiguous Follicular Lymphoma / Ann Arbor Stage II Grade 3 Non-Contiguous Follicular Lymphoma / Ann Arbor Stage III Diffuse Large B-Cell Lymphoma / Ann Arbor Stage III Grade 3 Follicular Lymphoma / Ann Arbor Stage IV Diffuse Large B-Cell Lymphoma / Ann Arbor Stage IV Grade 3 Follicular Lymphoma / CD20 Positive / Grade 3b Follicular Lymphoma / Human Immunodeficiency Virus (HIV) Infections / Plasmablastic Lymphoma / Primary Effusion Lymphomas / Recurrent Adult Diffuse Large Cell Lymphoma / Recurrent Diffuse Large B-Cell Lymphoma / Recurrent Grade 3 Follicular Lymphoma / Stage I Adult Diffuse Large Cell Lymphoma / Stage I Diffuse Large B-Cell Lymphoma / Stage I Grade 3 Follicular Lymphoma / Stage II Contiguous Adult Diffuse Large Cell Lymphoma / Stage II Diffuse Large B-Cell Lymphoma / Stage II Grade 3 Contiguous Follicular Lymphoma / Stage II Grade 3 Non-Contiguous Follicular Lymphoma / Stage II Non-Contiguous Adult Diffuse Large Cell Lymphoma / Stage III Adult Diffuse Large Cell Lymphoma / Stage III Diffuse Large B-Cell Lymphoma / Stage III Grade 3 Follicular Lymphoma / Stage IV Adult Diffuse Large Cell Lymphoma / Stage IV Diffuse Large B-Cell Lymphoma / Stage IV Grade 3 Follicular Lymphoma1
1, 2Active Not RecruitingTreatmentAdenocarcinoma of the Prostate / Hormone-Resistant Prostate Cancer / Recurrent Prostate Cancer / Stage IV Prostate Cancer1
1, 2Active Not RecruitingTreatmentAnaplastic Large Cell Lymphoma, ALK-Negative / Anaplastic Large Cell Lymphoma, ALK-Positive / Hepatosplenic T-Cell Lymphoma / Peripheral T-Cell Lymphoma, Not Otherwise Specified / Stage II Angioimmunoblastic T-cell Lymphoma / Stage II Enteropathy-Associated T-Cell Lymphoma / Stage III Angioimmunoblastic T-cell Lymphoma / Stage III Enteropathy-Associated T-Cell Lymphoma / Stage IV Angioimmunoblastic T-cell Lymphoma / Stage IV Enteropathy-Associated T-Cell Lymphoma1
1, 2Active Not RecruitingTreatmentAnn Arbor Stage II Non-Hodgkin Lymphoma / Ann Arbor Stage III Non-Hodgkin Lymphoma / Ann Arbor Stage IV Non-Hodgkin Lymphoma / Stage II Contiguous Adult Diffuse Large Cell Lymphoma / Stage II Non-Contiguous Adult Diffuse Large Cell Lymphoma / Stage III Adult Diffuse Large Cell Lymphoma / Stage IV Adult Diffuse Large Cell Lymphoma1
1, 2Active Not RecruitingTreatmentDiffuse B-Cell Lymphoma1
1, 2Active Not RecruitingTreatmentDiffuse Large B-Cell Lymphoma, Lymphoma Follicular / Diffuse Large B-Cell Lymphoma, Lymphoma, Follicular1
1, 2Active Not RecruitingTreatmentGiant Cells Arteritis / Temporal Arteritis1
1, 2Active Not RecruitingTreatmentLymphoma, Large B-Cell, Diffuse (DLBCL)2
1, 2Active Not RecruitingTreatmentMalignant Lymphomas1
1, 2Active Not RecruitingTreatmentMultiple Myeloma (MM)2
1, 2Active Not RecruitingTreatmentProstate Cancer1
1, 2CompletedTreatmentAdenocarcinoma of the Prostate / Hormone-Resistant Prostate Cancer / Recurrent Prostate Cancer / Stage IV Prostate Cancer1
1, 2CompletedTreatmentAdenocarcinoma of the Prostate / Recurrent Prostate Cancer / Stage IV Prostate Cancer1
1, 2CompletedTreatmentAdult T-cell lymphomas/leukaemias1
1, 2CompletedTreatmentCNI Side Effects1
1, 2CompletedTreatmentCastrate-resistant Prostate Cancer (CRPC)1
1, 2CompletedTreatmentCastrate-resistant Prostate Cancer (CRPC) / Malignancies / Mestastatic Prostate Cancer / Prostate Cancer1
1, 2CompletedTreatmentFollicular Lymphoma (FL) / Lymphoma, B-Cell1
1, 2CompletedTreatmentFollicular Lymphoma (FL) / Lymphoma, Large B-Cell, Diffuse (DLBCL) / Mantle Cell Lymphoma (MCL) / Marginal Zone B-Cell Lymphoma / Marginal Zone Lymphoma1
1, 2CompletedTreatmentHodgkins Disease (HD)1
1, 2CompletedTreatmentHodgkins Disease (HD) / Malignant Lymphomas1
1, 2CompletedTreatmentKidney Diseases / Transplant, Kidney / Transplantation, Kidney / Transplantation, Renal1
1, 2CompletedTreatmentLeukemias1
1, 2CompletedTreatmentLeukemias / Malignant Lymphomas1
1, 2CompletedTreatmentLymphoma, B-Cell, Non-Hodgkin's Lymphoma / Non-Hodgkin's Lymphoma (NHL)1
1, 2CompletedTreatmentLymphoma, Large B-Cell, Diffuse (DLBCL)2
1, 2CompletedTreatmentMalignant Lymphomas2
1, 2CompletedTreatmentMalignant Lymphomas / Non-Hodgkin's Lymphoma (NHL)1
1, 2CompletedTreatmentMetastatic, Androgen Independent Prostate Cancer / Prostate Cancer1
1, 2CompletedTreatmentMultiple Myeloma (MM)5
1, 2CompletedTreatmentMultiple Myeloma and Plasma Cell Neoplasm1
1, 2CompletedTreatmentNon-Hodgkin's Lymphoma (NHL)1
1, 2CompletedTreatmentPlasma Cell Myeloma1
1, 2CompletedTreatmentProstate Cancer5
1, 2CompletedTreatmentProstate Cancer / Tumors1
1, 2CompletedTreatmentProstate Neoplasms1
1, 2CompletedTreatmentProstatic Neoplasms2
1, 2CompletedTreatmentRecurrent Childhood Acute Lymphoblastic Leukemia1
1, 2CompletedTreatmentRefractory Mantle Cell Lymphoma1
1, 2Not Yet RecruitingTreatmentALK-Positive Anaplastic Large Cell Lymphoma / EBV-Positive DLBCL, Nos / Follicular Lymphoma Grade IIIb / High-grade B-cell Lymphoma / Lymphoma, Large B-Cell, Diffuse (DLBCL) / Transformed Lymphoma1
1, 2Not Yet RecruitingTreatmentAcute T Cell Leukemia1
1, 2Not Yet RecruitingTreatmentLiving-Donor Kidney Transplants / Renal Transplant Recipient Patients1
1, 2Not Yet RecruitingTreatmentMultiple Myeloma (MM)1
1, 2RecruitingSupportive CareCancer Survivors / Cranial nerve disorder / Head and Neck Carcinoma1
1, 2RecruitingTreatmentALK- Anaplastic Large Cell Lymphoma (ALCL) / ALK- Anaplastic Largecell Lymphoma (ALCL) / Angioimmunoblastic T-cell Lymphoma (AITL) / Peripheral T-Cell Lymphoma (PTCL) / Peripheral T-cell Lymphomas Not Otherwise Specified (PTCL-NOS) / PTCL-NOS1
1, 2RecruitingTreatmentAcute Graft-Versus-Host Disease1
1, 2RecruitingTreatmentAcute Lymphoblastic Leukaemias (ALL) / B Acute Lymphoblastic Leukemia, Philadelphia Chromosome Negative / Leukemias / Untreated Adult Acute Lymphoblastic Leukemia1
1, 2RecruitingTreatmentAdult Burkitt Lymphoma / B-Cell Lymphoma, Unclassifiable, With Features Intermediate Between Diffuse Large B-Cell Lymphoma and Burkitt Lymphoma / Lymphoma, Large B-Cell, Diffuse (DLBCL) / MYC Gene Mutation / Plasmablastic Lymphoma1
1, 2RecruitingTreatmentAdult Grade III Lymphomatoid Granulomatosis / B-Cell Chronic Lymphocytic Leukemia / Contiguous Stage II Adult Diffuse Large Cell Lymphoma / Contiguous Stage II Adult Diffuse Mixed Cell Lymphoma / Contiguous Stage II Adult Diffuse Small Cleaved Cell Lymphoma / Contiguous Stage II Adult Immunoblastic Large Cell Lymphoma / Contiguous Stage II Grade 1 Follicular Lymphoma / Contiguous Stage II Grade 2 Follicular Lymphoma / Contiguous Stage II Grade 3 Follicular Lymphoma / Contiguous Stage II Mantle Cell Lymphoma / Contiguous Stage II Marginal Zone Lymphoma / Contiguous Stage II Small Lymphocytic Lymphoma / Cutaneous B-Cell Non-Hodgkin Lymphoma / Extranodal Marginal Zone B-cell Lymphoma of Mucosa-associated Lymphoid Tissue / Intraocular Lymphoma / Nodal marginal zone B-cell lymphomas / Noncontiguous Stage II Adult Diffuse Large Cell Lymphoma / Noncontiguous Stage II Adult Diffuse Mixed Cell Lymphoma / Noncontiguous Stage II Adult Diffuse Small Cleaved Cell Lymphoma / Noncontiguous Stage II Adult Immunoblastic Large Cell Lymphoma / Noncontiguous Stage II Grade 1 Follicular Lymphoma / Noncontiguous Stage II Grade 2 Follicular Lymphoma / Noncontiguous Stage II Grade 3 Follicular Lymphoma / Noncontiguous Stage II Mantle Cell Lymphoma / Noncontiguous Stage II Marginal Zone Lymphoma / Noncontiguous Stage II Small Lymphocytic Lymphoma / Progressive Hairy Cell Leukemia, Initial Treatment / Small Intestine Lymphoma / Splenic Marginal Zone Lymphoma / Stage 0 Chronic Lymphocytic Leukemia / Stage I Adult Diffuse Large Cell Lymphoma / Stage I Adult Diffuse Mixed Cell Lymphoma / Stage I Adult Diffuse Small Cleaved Cell Lymphoma / Stage I Adult Hodgkin Lymphoma / Stage I Adult Immunoblastic Large Cell Lymphoma / Stage I Chronic Lymphocytic Leukemia / Stage I Grade 1 Follicular Lymphoma / Stage I Grade 2 Follicular Lymphoma / Stage I Grade 3 Follicular Lymphoma / Stage I Mantle Cell Lymphoma / Stage I Marginal Zone Lymphoma / Stage I Small Lymphocytic Lymphoma / Stage II Adult Hodgkin Lymphoma / Stage II Chronic Lymphocytic Leukemia / Stage II Small Lymphocytic Lymphoma / Stage III Adult Diffuse Large Cell Lymphoma / Stage III Adult Diffuse Mixed Cell Lymphoma / Stage III Adult Diffuse Small Cleaved Cell Lymphoma / Stage III Adult Hodgkin Lymphoma / Stage III Adult Immunoblastic Large Cell Lymphoma / Stage III Chronic Lymphocytic Leukemia / Stage III Grade 1 Follicular Lymphoma / Stage III Grade 2 Follicular Lymphoma / Stage III Grade 3 Follicular Lymphoma / Stage III Mantle Cell Lymphoma / Stage III Marginal Zone Lymphoma / Stage III Small Lymphocytic Lymphoma / Stage IV Adult Diffuse Large Cell Lymphoma / Stage IV Adult Diffuse Mixed Cell Lymphoma / Stage IV Adult Diffuse Small Cleaved Cell Lymphoma / Stage IV Adult Hodgkin Lymphoma / Stage IV Adult Immunoblastic Large Cell Lymphoma / Stage IV Chronic Lymphocytic Leukemia / Stage IV Grade 1 Follicular Lymphoma / Stage IV Grade 2 Follicular Lymphoma / Stage IV Grade 3 Follicular Lymphoma / Stage IV Mantle Cell Lymphoma / Stage IV Marginal Zone Lymphoma / Stage IV Small Lymphocytic Lymphoma / Testicular Lymphoma / Untreated Hairy Cell Leukemia / Waldenström's Macroglobulinemia (WM)1
1, 2RecruitingTreatmentAggressive Non-Hodgkin Lymphoma / B-cell Non-Hodgkin's Lymphomas / CD20 Positive / Diffuse Large B-Cell Lymphoma Unclassifiable / Intravascular Large B-Cell Lymphoma / Primary Mediastinal (Thymic) Large B-cell Lymphoma / T-Cell/Histiocyte-Rich Large B-Cell Lymphoma / Transformed Follicular Lymphoma to Diffuse Large B-Cell Lymphoma1
1, 2RecruitingTreatmentAirway Inflammation1
1, 2RecruitingTreatmentB-cell Non-Hodgkin's Lymphomas1
1, 2RecruitingTreatmentCastration Levels of Testosterone / Castration-Resistant Prostate Carcinoma / Hormone-Resistant Prostate Cancer / Metastatic Hormone Refractory Prostate Cancer / Recurrent Prostate Carcinoma / Stage IV Prostate Cancer / Stage IV Prostate Cancer AJCC v71
1, 2RecruitingTreatmentContiguous Stage II Adult Diffuse Large Cell Lymphoma / Noncontiguous Stage II Adult Diffuse Large Cell Lymphoma / Stage I Adult Diffuse Large Cell Lymphoma / Stage III Adult Diffuse Large Cell Lymphoma / Stage IV Adult Diffuse Large Cell Lymphoma1
1, 2RecruitingTreatmentDiamond Blackfan Anemia1
1, 2RecruitingTreatmentDisseminated Sclerosis1
1, 2RecruitingTreatmentLeber Congenital Amaurosis (LCA)1
1, 2RecruitingTreatmentLymphoma, B-Cell / Primary Effusion Lymphomas1
1, 2RecruitingTreatmentLymphoma, Hodgkins1
1, 2RecruitingTreatmentLymphoma, Large B-Cell, Diffuse (DLBCL)1
1, 2RecruitingTreatmentMalignant Lymphomas1
1, 2RecruitingTreatmentMetastatic Castration Resistant Prostate Cancer1
1, 2RecruitingTreatmentMetastatic Castration Resistant Prostate Cancer (mCRPC)1
1, 2RecruitingTreatmentNon-Hodgkin's Lymphoma (NHL)1
1, 2RecruitingTreatmentOrnithine Transcarbamylase (OTC) Deficiency1
1, 2RecruitingTreatmentProstate Cancer1
1, 2RecruitingTreatmentProstatic Neoplasms, Castration-Resistant1
1, 2RecruitingTreatmentRecurrent B Acute Lymphoblastic Leukemia / Recurrent T Acute Lymphoblastic Leukemia / Refractory B Acute Lymphoblastic Leukemia / Refractory T Acute Lymphoblastic Leukemia1
1, 2RecruitingTreatmentT Cell Non-Hodgkin's Lymphoma1
1, 2TerminatedTreatmentAdenocarcinoma of the Prostate / Prostate Cancer / Recurrent Prostate Cancer / Stage I Prostate Cancer / Stage III Prostate Cancer / Stage IV Prostate Cancer1
1, 2TerminatedTreatmentCastrate-resistant Prostate Cancer (CRPC) / Castrate-resistant Prostate Cancer Patients1
1, 2TerminatedTreatmentMalignant Lymphomas1
1, 2TerminatedTreatmentPain / Prostate Cancer1
1, 2TerminatedTreatmentProstate Cancer2
1, 2Unknown StatusTreatmentMalignant Lymphomas1
1, 2Unknown StatusTreatmentMultiple Myeloma (MM)1
1, 2WithdrawnTreatmentLarge Cell Lymphoma Arising in KSHV-associated Multicentric Castleman Disease / Primary Effusion Lymphomas1
1, 2WithdrawnTreatmentLarge-Cell Lymphoma, Diffuse / Lymphoma, Diffuse Large-Cell / Lymphoma, Diffuse Large-Cell B-cell / Lymphoma, Large B-Cell, Diffuse (DLBCL)1
2Active Not RecruitingSupportive CareLymphoma, Large B-Cell, Diffuse (DLBCL)1
2Active Not RecruitingTreatmentAIDS-Related Diffuse Large Cell Lymphoma / AIDS-Related Diffuse Mixed Cell Lymphoma / AIDS-Related Diffuse Small Cleaved Cell Lymphoma / AIDS-related Immunoblastic Large Cell Lymphoma / AIDS-Related Lymphoblastic Lymphoma / AIDS-related Peripheral/Systemic Lymphoma / AIDS-related Small Noncleaved Cell Lymphoma / Stage III AIDS-related Lymphoma / Stage IV AIDS-related Lymphoma1
2Active Not RecruitingTreatmentAcute GvHD1
2Active Not RecruitingTreatmentAcute Lymphoblastic Leukaemia Recurrent / Acute Lymphoblastic Leukaemias (ALL) / BCR-ABL1 Fusion Protein Expression / Blast Phase Chronic Myelogenous Leukemia, BCR-ABL1 Positive / Leukemias / Philadelphia Chromosome Positive / T(9;22)1
2Active Not RecruitingTreatmentAcute Lymphoblastic Leukaemias (ALL)1
2Active Not RecruitingTreatmentAcute Lymphoblastic Leukaemias (ALL) / Adult Acute Lymphoblastic Leukemia in Remission / Adult B Acute Lymphoblastic Leukemia / Adult B Acute Lymphoblastic Leukemia With t(9;22)(q34.1;q11.2); BCR-ABL1 / Adult B Acute Lymphoblastic Leukemia With t(9;22)(q34;q11.2); BCR-ABL1 / Adult L1 Acute Lymphoblastic Leukemia / Adult L2 Acute Lymphoblastic Leukemia / Adult T Acute Lymphoblastic Leukemia / Recurrent Adult Acute Lymphoblastic Leukemia / Untreated Adult Acute Lymphoblastic Leukemia1
2Active Not RecruitingTreatmentAcute Lymphoblastic Leukemia in Remission / Acute Lymphocytic Leukemia (ALL) / B Acute Lymphoblastic Leukemia / B Acute Lymphoblastic Leukemia, Philadelphia Chromosome Negative1
2Active Not RecruitingTreatmentAcute Lymphocytic Leukemia (ALL) / Adult Lymphoblastic Lymphoma1
2Active Not RecruitingTreatmentAcute,Leukemia, Lymphoid1
2Active Not RecruitingTreatmentAdenocarcinoma, Prostate / Diseases of Male Genital Organs / Prostate Cancer / PSA Level Greater Than Ten / Stage IIB Prostate Cancer AJCC v8 / Stage IIC Prostate Cancer AJCC v8 / Stage IIIA Prostate Cancer AJCC v8 / Stage IIIC Prostate Cancer AJCC v8 / Testosterone Greater Than 150 ng/dL1
2Active Not RecruitingTreatmentAdenocarcinoma, Prostate / High Risk Prostate Cancer / Prostate Cancer1
2Active Not RecruitingTreatmentAdenocarcinoma, Prostate / Hormone-Resistant Prostate Cancer / Recurrent Prostate Carcinoma / Stage IV Prostate Cancer1
2Active Not RecruitingTreatmentAdenocarcinoma, Prostate / Prostate Cancer / PSA Level Greater Than or Equal to 0.2 / PSA Progression / Recurrent Prostate Carcinoma1
2Active Not RecruitingTreatmentAdvanced Stage Diffuse Large B-Cell Non-Hodgkin's Lymphoma / Non-Hodgkin's Lymphoma (NHL)1
2Active Not RecruitingTreatmentAnn Arbor Stage II Diffuse Large B-Cell Lymphoma / Ann Arbor Stage III Diffuse Large B-Cell Lymphoma / Ann Arbor Stage IV Diffuse Large B-Cell Lymphoma / CD20 Positive / Stage II Diffuse Large B-Cell Lymphoma / Stage III Diffuse Large B-Cell Lymphoma / Stage IV Diffuse Large B-Cell Lymphoma1
2Active Not RecruitingTreatmentCastration Levels of Testosterone / Castration-Resistant Prostate Carcinoma / Hormone-Resistant Prostate Cancer / PSA Progression / Recurrent Prostate Carcinoma / Stage IV Prostate Cancer / Stage IV Prostate Cancer AJCC v71
2Active Not RecruitingTreatmentCastration Levels of Testosterone / Castration-Resistant Prostate Carcinoma / Metastatic Hormone Refractory Prostate Cancer / Prostate Cancer / PSA Progression / Stage IV Prostate Adenocarcinoma AJCC v71
2Active Not RecruitingTreatmentCastration Resistant Prostate Cancer (CRPC)1
2Active Not RecruitingTreatmentCastration-Resistant Prostate Cancer (CRPC)2
2Active Not RecruitingTreatmentClassical Hodgkin Lymphoma1
2Active Not RecruitingTreatmentDiffuse Large B-Cell Lymphoma Unclassifiable / Malignant Lymphomas1
2Active Not RecruitingTreatmentGraft Versus Host Disease (GVHD) / Graft-versus-host Disease (GVHD)1
2Active Not RecruitingTreatmentHodgkins Disease (HD)1
2Active Not RecruitingTreatmentHormone-Resistant Prostate Cancer / Metastatic Hormone Refractory Prostate Cancer / Recurrent Prostate Carcinoma / Stage IV Prostate Adenocarcinoma1
2Active Not RecruitingTreatmentHormone-Resistant Prostate Cancer / Recurrent Prostate Cancer / Stage IV Prostate Cancer1
2Active Not RecruitingTreatmentLarge B-cell Diffuse Lymphoma of Testis / Primary Testicular Diffuse Large B-cell Lymphoma1
2Active Not RecruitingTreatmentLymphoma, Extranodal NK-T-Cell / T-Cell Lymphomas1
2Active Not RecruitingTreatmentLymphoma, Hodgkins3
2Active Not RecruitingTreatmentLymphoma, Large B-Cell, Diffuse (DLBCL)2
2Active Not RecruitingTreatmentLymphoma, Lymphoblastic1
2Active Not RecruitingTreatmentLymphoproliferative Disorders1
2Active Not RecruitingTreatmentMalignant Lymphomas7
2Active Not RecruitingTreatmentMalignant Lymphomas / Nonneoplastic Condition1
2Active Not RecruitingTreatmentMantle Cell Lymphoma (MCL) / Untreated1
2Active Not RecruitingTreatmentMetastatic Castration Resistant Prostate Cancer1
2Active Not RecruitingTreatmentMetastatic Hormone Refractory Prostate Cancer1
2Active Not RecruitingTreatmentMultiple Myeloma (MM)6
2Active Not RecruitingTreatmentMyelodysplastic Syndrome / Smith-Magenis Syndrome1
2Active Not RecruitingTreatmentNHL With Hemophagocytic Lymphohistiocytosis1
2Active Not RecruitingTreatmentNephritis, Lupus1
2Active Not RecruitingTreatmentPrimary Central Nervous System Lymphoma (PCNSL)1
2Active Not RecruitingTreatmentProstate Cancer9
2Active Not RecruitingTreatmentProstate Cancer / Prostatic Neoplasms1
2Active Not RecruitingTreatmentStage II Childhood Hodgkin Lymphoma / Stage III Childhood Hodgkin Lymphoma / Stage IV Childhood Hodgkin Lymphoma1
2Active Not RecruitingTreatmentStage III Prostate Adenocarcinoma / Stage III Prostate Adenocarcinoma AJCC v7 / Stage III Prostate Cancer / Stage III Prostate Cancer AJCC v7 / Stage IV Prostate Adenocarcinoma / Stage IV Prostate Adenocarcinoma AJCC v7 / Stage IV Prostate Cancer / Stage IV Prostate Cancer AJCC v71
2Active Not RecruitingTreatmentSystemic Sclerosis-Associated PAH / Systemic Sclerosis-Associated Pulmonary Arterial Hypertension1
2Active Not RecruitingTreatmentTransplantation, Kidney1
2CompletedNot AvailableMultiple Myeloma (MM)1
2CompletedDiagnosticMalignant Lymphomas1
2CompletedPreventionAdrenal Insufficiency1
2CompletedPreventionChronic Lung Diseases1
2CompletedPreventionSystemic Lupus Erythematosus (SLE)1
2CompletedSupportive CareBreast Cancer / Chronic Myeloproliferative Disorders / Gestational Trophoblastic Disease / Graft Versus Host Disease (GVHD) / Leukemias / Malignant Lymphomas / Multiple Myeloma and Plasma Cell Neoplasm / Myelodysplastic Syndromes / Myelodysplastic/Myeloproliferative Diseases / Neuroblastomas / Ovarian Cancer / Testicular germ cell tumour1
2CompletedSupportive CareItching1
2CompletedSupportive CareMalignancies1
2CompletedTreatmentAIDS-Associated Nephropathy / Human Immunodeficiency Virus (HIV) Infections1
2CompletedTreatmentAIDS-Related Diffuse Large Cell Lymphoma / AIDS-related Immunoblastic Large Cell Lymphoma / AIDS-related Peripheral/Systemic Lymphoma / AIDS-related Small Noncleaved Cell Lymphoma1
2CompletedTreatmentAcute Lymphoblastic Leukaemias (ALL)2
2CompletedTreatmentAdenocarcinoma of the Prostate / Recurrent Prostate Cancer / Stage IV Prostate Cancer1
2CompletedTreatmentAdenocarcinoma of the Prostate / Stage IIA Prostate Cancer / Stage IIB Prostate Cancer / Stage III Prostate Cancer / Stage IV Prostate Cancer1
2CompletedTreatmentAgnogenic Myeloid Metaplasia1
2CompletedTreatmentAgnogenic Myeloid Metaplasia / Myelofibrosis With Myeloid Metaplasia / Myeloid Metaplasia1
2CompletedTreatmentAmyotrophic Lateral Sclerosis (ALS)1
2CompletedTreatmentAnaplastic Large Cell Lymphoma / Angioimmunoblastic T-Cell Lymphoma / Hepatosplenic T-Cell Lymphoma / Peripheral T-Cell Lymphoma (PTCL)1
2CompletedTreatmentAsthma1
2CompletedTreatmentAutoimmune Hemolytic Disease (Cold Type) (Warm Type)1
2CompletedTreatmentB-cell Adult Acute Lymphoblastic Leukemia / B-cell Childhood Acute Lymphoblastic Leukemia / Recurrent Adult Acute Lymphoblastic Leukemia / Recurrent Adult Lymphoblastic Lymphoma / Recurrent Childhood Acute Lymphoblastic Leukemia / Recurrent Childhood Lymphoblastic Lymphoma / T-cell Adult Acute Lymphoblastic Leukemia / T-cell Childhood Acute Lymphoblastic Leukemia1
2CompletedTreatmentBirdshot Chorioretinopathy / Cystoid Macular Edema / Transient Partial Visual Loss1
2CompletedTreatmentBlood and Marrow Transplant (BMT) / Graft Versus Host Disease (GVHD)1
2CompletedTreatmentBrain and Central Nervous System Tumors1
2CompletedTreatmentCardiovascular Heart Disease / Heart Diseases / Myocarditis1
2CompletedTreatmentCastration Resistant Prostate Cancer (CRPC)1
2CompletedTreatmentChildhood Burkitt Lymphoma / Childhood Diffuse Large Cell Lymphoma / Childhood Immunoblastic Large Cell Lymphoma / Stage I Childhood Large Cell Lymphoma / Stage I Childhood Small Noncleaved Cell Lymphoma / Stage II Childhood Large Cell Lymphoma / Stage II Childhood Small Noncleaved Cell Lymphoma / Stage III Childhood Large Cell Lymphoma / Stage III Childhood Small Noncleaved Cell Lymphoma / Stage IV Childhood Large Cell Lymphoma / Stage IV Childhood Small Noncleaved Cell Lymphoma / Untreated Childhood Acute Lymphoblastic Leukemia1
2CompletedTreatmentChronic Graft Versus Host Disease1
2CompletedTreatmentChronic Hepatitis C Virus (HCV) Infection / Hepatitis C Viral Infection / Nonimmune Nonviral Causes of Liver Failure1
2CompletedTreatmentChronic Lung Diseases / Pulmonary Fibrosis / Sarcoidosis1
2CompletedTreatmentChronic Lymphocytic Leukaemia (CLL) / Leukemias1
2CompletedTreatmentChronic Myeloproliferative Disorders / Secondary Myelofibrosis1
2CompletedTreatmentChronic Renal Failure (CRF) / Transplantation, Kidney1
2CompletedTreatmentContiguous Stage II Adult Diffuse Large Cell Lymphoma / Noncontiguous Stage II Adult Diffuse Large Cell Lymphoma / Stage III Adult Diffuse Large Cell Lymphoma / Stage IV Adult Diffuse Large Cell Lymphoma1
2CompletedTreatmentCorticosteroid Resistant (CR) Asthmatics1
2CompletedTreatmentCrohn's Disease (CD)1
2CompletedTreatmentDisseminated Sclerosis / Relapsing Remitting Multiple Sclerosis (RRMS)1
2CompletedTreatmentEssential Thrombocythemia (ET) / Polycythemia Vera (PV) / Primary Myelofibrosis1
2CompletedTreatmentFollicular Lymphoma (FL)2
2CompletedTreatmentGastrointestinal Stromal Tumor(GIST)1
2CompletedTreatmentGiant Cell Myocarditis / Myocarditis1
2CompletedTreatmentGiant Cells Arteritis2
2CompletedTreatmentGranulomatosis With Polyangiitis / Inflammatory Reaction / Vasculitis1
2CompletedTreatmentHemangiomas1
2CompletedTreatmentHepatitis, Autoimmune1
2CompletedTreatmentHigh-risk Diffuse Large B-Cell Lymphoma / High-risk Diffuse Large B-Cell Lymphoma (DLBCL)1
2CompletedTreatmentHodgkins Disease (HD) / Lymphoma, Hodgkin Disease / Lymphoma, Hodgkins / Malignant Lymphomas1
2CompletedTreatmentHodgkins Disease (HD) / Pediatric1
2CompletedTreatmentHormone Refractory Prostate Cancer1
2CompletedTreatmentHormone Resistant Prostate Cancer / Metastatic Hormone Refractory Prostate Cancer1
2CompletedTreatmentHormone-Resistant Prostate Cancer / Stage IV Prostate Adenocarcinoma1
2CompletedTreatmentHuman Immunodeficiency Virus (HIV) Infections1
2CompletedTreatmentHuman Immunodeficiency Virus (HIV) Infections / Lymphoma, AIDS Related1
2CompletedTreatmentIdiopathic Pulmonary Fibrosis (IPF)1
2CompletedTreatmentIgA Glomerulonephritis1
2CompletedTreatmentLeukemias7
2CompletedTreatmentLeukemias / Malignant Lymphomas4
2CompletedTreatmentLeukemias / Malignant Lymphomas / Multiple Myleoma / Myelodysplastic Syndrome / Myeloproliferative Disorders1
2CompletedTreatmentLeukemias / Neutropenia / Thrombocytopenia1
2CompletedTreatmentLymphoma, B-Cell2
2CompletedTreatmentLymphoma, Diffuse Large-Cell1
2CompletedTreatmentLymphoma, Hodgkins2
2CompletedTreatmentLymphoma, Large B-Cell, Diffuse (DLBCL)4
2CompletedTreatmentLymphoma, Large B-Cell, Diffuse (DLBCL) / Poor prognosis1
2CompletedTreatmentMalignant Lymphomas35
2CompletedTreatmentMalignant Lymphomas / Multiple Myeloma and Plasma Cell Neoplasm1
2CompletedTreatmentMalignant Lymphomas / Small Intestine Cancer1
2CompletedTreatmentMantle Cell Lymphoma (MCL)1
2CompletedTreatmentMelanoma1
2CompletedTreatmentMetastatic Castration Resistant Prostate Cancer1
2CompletedTreatmentMetastatic ER+ Her2- Breast Cancer / One to five years postmenopausal1
2CompletedTreatmentMetastatic Hormone Refractory Prostate Cancer2
2CompletedTreatmentMultiple Myeloma (MM)9
2CompletedTreatmentMultiple Myeloma and Plasma Cell Neoplasm3
2CompletedTreatmentMyelodysplastic Syndrome1
2CompletedTreatmentMyelodysplastic Syndromes1
2CompletedTreatmentMyeloproliferative Disorders1
2CompletedTreatmentNephritis, Lupus3
2CompletedTreatmentNephritis, Lupus / Systemic Lupus Erythematosus (SLE)1
2CompletedTreatmentNephrotic Syndrome / Systemic Lupus Erythematosus (SLE)1
2CompletedTreatmentNon-Germinal B-Cell-like (GCB) Diffuse Large B-cell Lymphoma (DLBCL)1
2CompletedTreatmentNon-Hodgkin's Lymphoma (NHL)4
2CompletedTreatmentOral Lichen Planus1
2CompletedTreatmentOvarian Cancer / Prostate Cancer1
2CompletedTreatmentPosttransplant Lymphoproliferative Disorder / PTLD1
2CompletedTreatmentPemphigus Vulgaris (PV)1
2CompletedTreatmentPeripheral T-Cell Lymphoma (PTCL)3
2CompletedTreatmentPolycythemia Vera (PV) / Thrombocythemia1
2CompletedTreatmentPolymorphism, Genetic / Prostate Cancer1
2CompletedTreatmentProstate Cancer24
2CompletedTreatmentProstate Cancer / Prostate Neoplasms1
2CompletedTreatmentProstate Cancer / Prostate Neoplasms / Prostatic Neoplams / Prostatic Neoplasms1
2CompletedTreatmentProstate Cancer / Prostatic Neoplasms1
2CompletedTreatmentProstate Neoplasms1
2CompletedTreatmentProstatic Neoplasms5
2CompletedTreatmentRelapsed Follicular Lymphoma1
2CompletedTreatmentRenal Cancers1
2CompletedTreatmentRheumatoid Arthritis3
2CompletedTreatmentSarcomas1
2CompletedTreatmentSciatica1
2CompletedTreatmentSystemic Lupus Erythematosus (SLE)1
2CompletedTreatmentThymoma and Thymic Carcinoma1
2CompletedTreatmentTransplantation, Kidney1
2CompletedTreatmentTransplantation, Liver1
2CompletedTreatmentUntreated T-Cell Angioimmunoblastic Lymphoma1
2CompletedTreatmentUveitis1
2CompletedTreatmentVestibular Diseases / Vestibular Neuronitis1
2Enrolling by InvitationSupportive CareCastration-Resistant Prostate Cancer (CRPC) / Prostate Cancer1
2Enrolling by InvitationTreatmentAlcoholic Hepatitis (AH)1
2Enrolling by InvitationTreatmentBecker's Muscular Dystrophy (BMD) / Limb-Girdle Muscular Dystrophies1
2Enrolling by InvitationTreatmentGraft Versus Host Disease (GVHD)1
2Not Yet RecruitingTreatmentAdenocarcinoma, Prostate / Castration-Resistant Prostate Cancer (CRPC) / Metastatic Hormone Refractory Prostate Cancer / Prostate Carcinoma Metastatic in the Bone / Prostate Small Cell Carcinoma1
2Not Yet RecruitingTreatmentAdenocarcinoma, Prostate / PSA Level Greater Than or Equal to 0.5 / PSA Level Less Than Ten1
2Not Yet RecruitingTreatmentAlcoholic Hepatitis (AH)1
2Not Yet RecruitingTreatmentLymphoma, Large B-Cell, Diffuse (DLBCL)1
2Not Yet RecruitingTreatmentLymphoma, Large B-Cell, Diffuse (DLBCL) / Malignancies1
2Not Yet RecruitingTreatmentMinimal Change Nephrotic Syndrome (MCNS)1
2Not Yet RecruitingTreatmentProstate Cancer1
2RecruitingScreeningCastrate Sensitive Prostate Cancer1
2RecruitingTreatmentAcute Lymphoblastic Leukaemia Recurrent / AIDS-Related Burkitt Lymphoma / Atypical Burkitt/Burkitt-Like Lymphoma / High Grade B-Cell Lymphoma With MYC and BCL2 or BCL6 Rearrangements / High Grade B-Cell Lymphoma With MYC, BCL2, and BCL6 Rearrangements / High-Grade B-Cell Lymphoma With MYC, BCL2, and BCL6 Rearrangements / Leukemias / Recurrent Adult Acute Lymphoblastic Leukemia / Recurrent Adult Burkitt Lymphoma / Recurrent Burkitt Lymphoma / Recurrent Childhood Acute Lymphoblastic Leukemia / Recurrent Childhood Burkitt Lymphoma / Refractory Acute Lymphoblastic Leukemia / Refractory Adult Acute Lymphoblastic Leukemia / Refractory Burkitt Lymphoma / Refractory Childhood Acute Lymphoblastic Leukemia1
2RecruitingTreatmentALL (Acute Lymphoblastic Leukemia) / B-cell Acute Lymphoblastic Leukemia / Leukemias1
2RecruitingTreatmentAbnormal DNA Repair / Hormone-Resistant Prostate Cancer / Metastatic Hormone Refractory Prostate Cancer / Prostate Cancer Metastatic Castration-Resistant / Stage IV Prostate Cancer1
2RecruitingTreatmentAccelerated Phase Chronic Myelogenous Leukemia, BCR-ABL1 Positive / Acute Lymphoblastic Leukaemias (ALL) / Adult Acute Lymphoblastic Leukemia in Complete Remission / B Acute Lymphoblastic Leukemia With t(9;22)(q34.1;q11.2); BCR-ABL1 / Blast Phase Chronic Myelogenous Leukemia, BCR-ABL1 Positive / Leukemias / Philadelphia Chromosome Positive / Untreated Adult Acute Lymphoblastic Leukemia1
2RecruitingTreatmentAcute Leukemias of Ambiguous Lineage / B Acute Lymphoblastic Leukemia / Childhood B Acute Lymphoblastic Leukemia / KMT2A Gene Rearrangement / Mixed Phenotype Acute Leukemia (MPAL)1
2RecruitingTreatmentAcute Lymphoblastic Leukaemias (ALL) / Adult Acute Lymphoblastic Leukemia / Adult Lymphoblastic Lymphoma / CD20 Positive / Lymphoma, Lymphoblastic / Philadelphia Chromosome Positive1
2RecruitingTreatmentAcute Lymphoblastic Leukaemias (ALL) / B Acute Lymphoblastic Leukemia / B Acute Lymphoblastic Leukemia With t(9;22)(q34.1;q11.2); BCR-ABL1 / B Acute Lymphoblastic Leukemia With t(9;22)(q34;q11.2); BCR-ABL1 / B Acute Lymphoblastic Leukemia, Philadelphia Chromosome Negative / Philadelphia Chromosome Positive / Recurrent Adult Acute Lymphoblastic Leukemia / Refractory Adult Acute Lymphoblastic Leukemia / Untreated Adult Acute Lymphoblastic Leukemia1
2RecruitingTreatmentAcute Lymphoblastic Leukaemias (ALL) / B Acute Lymphoblastic Leukemia / B Lymphoblastic Lymphoma / Leukemias1
2RecruitingTreatmentAcute Lymphoblastic Leukaemias (ALL) / Leukemias / Lymphoma, Lymphoblastic / T Acute Lymphoblastic Leukemia / T Lymphoblastic Lymphoma1
2RecruitingTreatmentAdenocarcinoma, Prostate / Metastatic Hormone Refractory Prostate Cancer / Prostate Carcinoma Metastatic in the Bone / Stage IV Prostate Cancer AJCC v8 / Stage IVA Prostate Cancer AJCC v8 / Stage IVB Prostate Cancer AJCC v81
2RecruitingTreatmentAdult T-Cell Leukemia/Lymphoma / Anaplastic Large Cell Lymphoma, ALK-Negative / Anaplastic Large Cell Lymphoma, ALK-Positive / Angioimmunoblastic T-Cell Lymphoma / Ann Arbor Stage II Noncutaneous Anaplastic Large Cell Lymphoma / Ann Arbor Stage III Noncutaneous Anaplastic Large Cell Lymphoma / Ann Arbor Stage IV Noncutaneous Anaplastic Large Cell Lymphoma / CD30-Positive Neoplastic Cells Present / Enteropathy-Associated T-Cell Lymphoma / Hepatosplenic T-Cell Lymphoma / Mature T-Cell and NK-Cell Non-Hodgkin Lymphoma / Peripheral T-Cell Lymphoma, Not Otherwise Specified / Stage III Anaplastic Large Cell Lymphoma / Stage IV Anaplastic Large Cell Lymphoma1
2RecruitingTreatmentAggressive Non-Hodgkin Lymphoma1
2RecruitingTreatmentAggressive Non-Hodgkin Lymphoma / Ann Arbor Stage I Primary Mediastinal (Thymic) Large B-Cell Cell Lymphoma / Ann Arbor Stage II B-Cell Non-Hodgkin Lymphoma / Ann Arbor Stage II Primary Mediastinal (Thymic) Large B-Cell Cell Lymphoma / Ann Arbor Stage III B-Cell Non-Hodgkin Lymphoma / Ann Arbor Stage III Primary Mediastinal (Thymic) Large B-Cell Cell Lymphoma / Ann Arbor Stage IV B-Cell Non-Hodgkin Lymphoma / Ann Arbor Stage IV Primary Mediastinal (Thymic) Large B-Cell Cell Lymphoma / High Grade B-Cell Lymphoma With MYC and BCL2 and/or BCL6 Rearrangements / High Grade B-Cell Lymphoma, Not Otherwise Specified / Indolent Non-Hodgkin's Lymphomas / Lymphoma, Large B-Cell, Diffuse (DLBCL) / Mediastinal B-Cell Lymphoma, Unclassifiable, With Features Intermediate Between Diffuse Large B-Cell Lymphoma and Classic Hodgkin Lymphoma / Transformed Non-Hodgkin Lymphoma1
2RecruitingTreatmentAll1
2RecruitingTreatmentAngioimmunoblastic T-Cell Lymphoma1
2RecruitingTreatmentAntibody-mediated Rejection / Lung Transplant Rejection1
2RecruitingTreatmentAutoimmune Diseases1
2RecruitingTreatmentAutoimmune Diseases / Autoimmune Disorders / Autologous Transplant Autoimmune / CIDP Transplant / HCT for Neurologic Autoimmune Disorders / MS Stem Cell Transplant / Multiple Sclerosis Stem Cell Transplant / Multiple Sclerosis Transplant / Myasthenia Gravis Transplant / Neurologic Autoimmune Disease / Stiff Person Syndrome1
2RecruitingTreatmentB Acute Lymphoblastic Leukemia / CRLF2 Positive / Leukemias / Recurrent Ph-Like Acute Lymphoblastic Leukemia / Refractory Ph-Like Acute Lymphoblastic Leukemia1
2RecruitingTreatmentB-cell Non-Hodgkin's Lymphomas1
2RecruitingTreatmentCardiac Transplant1
2RecruitingTreatmentCastration Levels of Testosterone / Castration-Resistant Prostate Carcinoma / Metastatic Prostate Carcinoma in the Soft Tissue / Prostate Carcinoma Metastatic in the Bone / PSA Progression / Stage IV Prostate Adenocarcinoma AJCC v7 / Stage IV Prostate Cancer AJCC v71
2RecruitingTreatmentCastration-Resistant Prostate Cancer (CRPC) / Metastatic Castration Resistant Prostate Cancer1
2RecruitingTreatmentCastration-Resistant Prostate Cancer (CRPC) / Prostate Cancer1
2RecruitingTreatmentCastration-Sensitive Prostate Carcinoma / Metastatic Prostatic Adenocarcinoma / Stage IV Prostate Cancer / Stage IVA Prostate Cancer / Stage IVB Prostate Cancer1
2RecruitingTreatmentDouble Expressor Lymphoma1
2RecruitingTreatmentDuchenne's Muscular Dystrophy (DMD)1
2RecruitingTreatmentExperimental Tumor1
2RecruitingTreatmentFocal Segmental Glomerulosclerosis (FSGS) / Transplantation, Kidney1
2RecruitingTreatmentGraft Versus Host Disease, Acute1
2RecruitingTreatmentHHV-8 / Human Immunodeficiency Virus (HIV) / Lymphoproliferative Disorders / Malignancies1
2RecruitingTreatmentHenoch-Schoenlein Purpura Nephritis2
2RecruitingTreatmentHigh-grade B-cell Lymphoma / Lymphoma, B Cell / Lymphoma, B-Cell / Lymphoma, Large B-Cell, Diffuse (DLBCL) / Malignant Lymphomas1
2RecruitingTreatmentHuman Immunodeficiency Virus (HIV) / Lymphoma, Large B-Cell, Diffuse (DLBCL)1
2RecruitingTreatmentLarge B Cell Lymphoma1
2RecruitingTreatmentLeukaemia, Lymphoblastic1
2RecruitingTreatmentLeukemias1
2RecruitingTreatmentAdvanced thymic carcinoma / Lung Cancer Metastatic / Lung Cancer Non-Small Cell Cancer (NSCLC) / Lung Cancer Small Cell Lung Cancer (SCLC) / Lung Cancers / Pleural Mesotheliomas1
2RecruitingTreatmentLymphoma, Hodgkins2
2RecruitingTreatmentLymphoma, Large B-Cell, Diffuse (DLBCL)7
2RecruitingTreatmentLymphoma, Lymphoblastic1
2RecruitingTreatmentMalignancies1
2RecruitingTreatmentMetastatic Castration Resistant Prostate Cancer1
2RecruitingTreatmentMetastatic Hormone Refractory Prostate Cancer1
2RecruitingTreatmentMetastatic Hormone Refractory Prostate Cancer / Prostate Cancer1
2RecruitingTreatmentMetastatic Hormone Refractory Prostate Cancer / Recurrent Prostate Carcinoma / Stage IV Prostate Cancer1
2RecruitingTreatmentMulticentric Castleman Disease1
2RecruitingTreatmentMultiple Myeloma (MM)2
2RecruitingTreatmentNon-Infectious Uveitis / Noninfectious Uveitis1
2RecruitingTreatmentPatients Relapsing Refractory Giant Cell Arteritis1
2RecruitingTreatmentPatients With Newly Diagnosed Active NISU1
2RecruitingTreatmentPeripheral T Cell Lymphoma (PTCL)1
2RecruitingTreatmentPeripheral T-Cell Lymphoma (PTCL)2
2RecruitingTreatmentPolyangiitis, Granulomatosis With1
2RecruitingTreatmentPosttransplant Lymphoproliferative Disorder1
2RecruitingTreatmentPrecursor Cell Lymphoblastic Leukemia-Lymphoma1
2RecruitingTreatmentProstate Cancer11
2RecruitingTreatmentProstate Cancer / Prostate Cancer Aggressiveness1
2RecruitingTreatmentProstatic Neoplasms3
2RecruitingTreatmentStage II Prostate Adenocarcinoma / Stage III Prostate Adenocarcinoma1
2RecruitingTreatmentSudden Sensorineural Hearing Loss (SSNHL)1
2RecruitingTreatmentTransplant, Kidney1
2SuspendedTreatmentGrade 1 Follicular Lymphoma / Grade 2 Follicular Lymphoma / Grade 3a Follicular Lymphoma / Recurrent Follicular Lymphoma / Refractory Follicular Lymphoma1
2TerminatedPreventionCryptogenic Organizing Pneumonia / Lung Diseases, Interstitial / Obliterative Bronchiolitis / Respiratory Tract Infections (RTI)1
2TerminatedSupportive CareDiarrhea / Hormone-Resistant Prostate Cancer / Recurrent Prostate Cancer / Stage I Prostate Cancer / Stage IIA Prostate Cancer / Stage IIB Prostate Cancer / Stage III Prostate Cancer / Stage IV Prostate Cancer1
2TerminatedTreatmentAdenocarcinoma of the Prostate / Stage IV Prostate Cancer1
2TerminatedTreatmentAnaplastic Large Cell Lymphoma1
2TerminatedTreatmentCastration Resistant Prostate Cancer (CRPC) / Prostate Cancer / Prostatic Neoplasms1
2TerminatedTreatmentCholesterol Embolism Systemic1
2TerminatedTreatmentChurg-Strauss Syndrome (CSS)1
2TerminatedTreatmentContiguous Stage II Adult Diffuse Large Cell Lymphoma / Extranodal Marginal Zone B-cell Lymphoma of Mucosa-associated Lymphoid Tissue / Nodal marginal zone B-cell lymphomas / Noncontiguous Stage II Adult Diffuse Large Cell Lymphoma / Splenic Marginal Zone Lymphoma / Stage I Adult Diffuse Large Cell Lymphoma / Testicular Lymphoma / Waldenström's Macroglobulinemia (WM)1
2TerminatedTreatmentContiguous Stage II Adult Diffuse Large Cell Lymphoma / Noncontiguous Stage II Adult Diffuse Large Cell Lymphoma / Stage III Adult Diffuse Large Cell Lymphoma / Stage IV Adult Diffuse Large Cell Lymphoma1
2TerminatedTreatmentCryoglobulinemia / Systemic Vasculitis1
2TerminatedTreatmentEnd-Stage Renal Disease (ESRD)1
2TerminatedTreatmentFollicular Lymphoma, Grade 3b / Lymphoma, Large B-Cell, Diffuse (DLBCL) / Transformed Lymphoma / DLBCL1
2TerminatedTreatmentGraft Versus Host Disease (GVHD)1
2TerminatedTreatmentHaemoglobinopathies congenital / Hemoglobin SC Disease / Sickle Cell Anemia / Thalassaemic disorders / Thalassemia Major (TM)1
2TerminatedTreatmentHemangiomas1
2TerminatedTreatmentHodgkins Disease (HD)1
2TerminatedTreatmentHormone Refractory Prostate Cancer1
2TerminatedTreatmentInflammatory Diseases / Polymyalgia Rheumatica1
2TerminatedTreatmentLeukemias1
2TerminatedTreatmentLeukemias / Lymphoma, Lymphoblastic / Malignant Lymphomas / Precursor-B Acute Lymphoblastic Leukemia1
2TerminatedTreatmentLeukemias / Malignant Lymphomas1
2TerminatedTreatmentLymphatic Diseases / Lymphoma, B-Cell1
2TerminatedTreatmentLymphoma, B-Cell / Lymphoma, Large B-Cell, Diffuse (DLBCL)1
2TerminatedTreatmentLymphoma, Hodgkins1
2TerminatedTreatmentLymphoma, Large B-Cell, Diffuse (DLBCL)1
2TerminatedTreatmentMalignant Lymphomas3
2TerminatedTreatmentMetastatic Castrate-Resistant Prostate Cancer / Prostate Cancer / Prostate Specific Antigen1
2TerminatedTreatmentMetastatic Hormone Refractory Prostate Cancer2
2TerminatedTreatmentMetastatic Renal Cancer1
2TerminatedTreatmentNon-Hodgkin's Lymphoma (NHL)2
2TerminatedTreatmentPlasma Cell Myeloma1
2TerminatedTreatmentPolymyalgia Rheumatica1
2TerminatedTreatmentProstate Cancer4
2TerminatedTreatmentRenal Transplant Recipient Patients1
2TerminatedTreatmentRheumatoid Arthritis2
2TerminatedTreatmentSystemic Lupus Erythematosus (SLE)1
2TerminatedTreatmentT-Cell Non-Hodgkin Lymphoma1
2TerminatedTreatmentTransplantation, Kidney1
2Unknown StatusTreatmentAggressive Non-Hodgkin's Lymphoma in the Elderly1
2Unknown StatusTreatmentAnemia, Hemolytic, Autoimmune / Anemias / Autoimmune Diseases / Hematologic Diseases / Hemolysis / Hemolytic Anemia / Immune System Diseases / Pathologic Processes1
2Unknown StatusTreatmentCellulitis / Erysipelas1
2Unknown StatusTreatmentHIV-associated Hodgkin Lymphoma1
2Unknown StatusTreatmentLeukemias1
2Unknown StatusTreatmentLymphoma, Large B-Cell, Diffuse (DLBCL)1
2Unknown StatusTreatmentLymphoma, Large B-Cell, Diffuse (DLBCL) / Non-Hodgkin's Lymphoma (NHL)1
2Unknown StatusTreatmentLymphoma, Lymphoblastic1
2Unknown StatusTreatmentMalignant Lymphomas7
2Unknown StatusTreatmentMantle Cell Lymphoma (MCL)1
2Unknown StatusTreatmentMyelodysplastic Syndrome1
2Unknown StatusTreatmentRenal Insufficiency,Chronic / Transplantation, Liver1
2Unknown StatusTreatmentRetroperitoneal Fibrosis1
2WithdrawnBasic SciencePost-menopausal ER+ Stage I-IIIA Primary Operable Breast Cancer1
2WithdrawnOtherHepatitis C Viral Infection1
2WithdrawnSupportive CareDuchenne's Muscular Dystrophy (DMD)1
2WithdrawnTreatmentAcute Interstitial Nephritis1
2WithdrawnTreatmentAdenocarcinoma of the Prostate / Prostate Cancer / Stage I Prostate Cancer / Stage II Prostate Cancer1
2WithdrawnTreatmentAsthma1
2WithdrawnTreatmentB Acute Lymphoblastic Leukemia / B Lymphoblastic Lymphoma / Recurrent Adult Acute Lymphoblastic Leukemia / Recurrent B Lymphoblastic Lymphoma / Recurrent T Lymphoblastic Leukemia/Lymphoma / Refractory B Lymphoblastic Lymphoma / Refractory T Lymphoblastic Lymphoma / T Acute Lymphoblastic Leukemia / T Lymphoblastic Lymphoma1
2WithdrawnTreatmentB-cell Adult Acute Lymphoblastic Leukemia / Blastic Phase Chronic Myelogenous Leukemia / Chronic Myelogenous Leukemia, BCR-ABL1 Positive / Philadelphia Chromosome Positive Adult Precursor Acute Lymphoblastic Leukemia / Untreated Adult Acute Lymphoblastic Leukemia1
2WithdrawnTreatmentCastrate-resistant Metastatic Prostate Cancer1
2WithdrawnTreatmentContiguous Stage II Adult Diffuse Large Cell Lymphoma / Noncontiguous Stage II Adult Diffuse Large Cell Lymphoma / Stage I Adult Diffuse Large Cell Lymphoma / Stage III Adult Diffuse Large Cell Lymphoma / Stage IV Adult Diffuse Large Cell Lymphoma1
2WithdrawnTreatmentFibrolamellar Hepatocellular Carcinoma / Hepatocellular Carcinoma (Fibrolamellar Variant) / Hepatocellular,Carcinoma1
2WithdrawnTreatmentLocalized Prostate Cancer / Prostate Cancer1
2WithdrawnTreatmentLung Cancers / Melanoma / Renal Cell Adenocarcinoma1
2WithdrawnTreatmentMalignant Lymphomas3
2WithdrawnTreatmentProstate Cancer3
2, 3Active Not RecruitingTreatmentChildhood B Acute Lymphoblastic Leukemia / Childhood Burkitt Leukemia / Childhood Diffuse Large Cell Lymphoma / Mediastinal (Thymic) Large B-Cell Lymphoma / Stage III Childhood Large Cell Lymphoma / Stage IV Childhood Large Cell Lymphoma1
2, 3CompletedTreatmentAcute Exacerbation of Chronic Obstructive Pulmonary Disease1
2, 3CompletedTreatmentAcute Urticaria1
2, 3CompletedTreatmentAdult B Acute Lymphoblastic Leukemia With t(9;22)(q34;q11.2); BCR-ABL1 / Childhood B Acute Lymphoblastic Leukemia With t(9;22)(q34;q11.2); BCR-ABL1 / Untreated Adult Acute Lymphoblastic Leukemia / Untreated Childhood Acute Lymphoblastic Leukemia1
2, 3CompletedTreatmentAllergies1
2, 3CompletedTreatmentAtherosclerosis / Coronary Artery Disease / Ischemic Heart Disease1
2, 3CompletedTreatmentChronic Graft Versus Host Disease1
2, 3CompletedTreatmentGlomerulonephritis, Membranous1
2, 3CompletedTreatmentGranulomatosis With Polyangiitis / Microscopic Polyangiitis / Vasculitis1
2, 3CompletedTreatmentHeart Failure, Hyperuricemia1
2, 3CompletedTreatmentHepatitis, Autoimmune1
2, 3CompletedTreatmentIdiopathic Membranous Nephropathy / Nephrotic Syndrome1
2, 3CompletedTreatmentImmune Thrombocytopenic Purpura ( ITP )1
2, 3CompletedTreatmentMultiple Myeloma (MM)1
2, 3CompletedTreatmentNephritis, Lupus1
2, 3CompletedTreatmentOptic Neuritis1
2, 3CompletedTreatmentPolymyalgia Rheumatica1
2, 3CompletedTreatmentProstate Cancer1
2, 3CompletedTreatmentRheumatoid Arthritis1
2, 3CompletedTreatmentSystemic Lupus Erythematosus (SLE)1
2, 3Not Yet RecruitingTreatmentAnti-Inflammatory Agents / Takayasu's Disease1
2, 3RecruitingTreatmentAcute Lymphoblastic Leukaemias (ALL) / Acute Lymphoblastic Lymphoma1
2, 3RecruitingTreatmentBCL2 Gene Translocation / C-Myc Translocation / Double-Expressor Lymphoma / High Grade B-Cell Lymphoma With MYC and BCL2 or BCL6 Rearrangements / High Grade B-Cell Lymphoma, Not Otherwise Specified / Lymphoma, Large B-Cell, Diffuse (DLBCL) / Neoplastic Cells With Double Expression of MYC and BCL2 Proteins Present1
2, 3RecruitingTreatmentBell's Palsy / Facial Nerve Paresis1
2, 3RecruitingTreatmentCroticosteroid Therapy / Idiopathic Thrombocytopenic Purpura1
2, 3RecruitingTreatmentFecal Microbiota Transplantation / Ulcerative Colitis1
2, 3RecruitingTreatmentHeart Failure / Hyperuricemia1
2, 3RecruitingTreatmentLangerhans Cell Histiocytosis (LCH)1
2, 3RecruitingTreatmentLymphoma, Large B-Cell, Diffuse (DLBCL)1
2, 3RecruitingTreatmentMature B-Cell Lymphoma1
2, 3RecruitingTreatmentMature B-cell Non-Hodgkin Lymphoma1
2, 3RecruitingTreatmentProstate Cancer1
2, 3SuspendedTreatmentCongestive Heart Failure1
2, 3TerminatedTreatmentDermatomyositis1
2, 3TerminatedTreatmentHemophilia A1
2, 3TerminatedTreatmentMalignant Lymphomas1
2, 3TerminatedTreatmentSystemic Lupus Erythematosus (SLE)1
2, 3Unknown StatusTreatmentIgG4-related Disease1
2, 3Unknown StatusTreatmentLeukemias1
2, 3Unknown StatusTreatmentSudden Loss of Hearing1
3Active Not RecruitingTreatmentAcute Graft-Versus-Host Disease / Graft-versus-host Disease (GVHD)1
3Active Not RecruitingTreatmentAcute Lymphoblastic Leukaemias (ALL)1
3Active Not RecruitingTreatmentAcute Lymphoblastic Leukaemias (ALL) / Adult B Acute Lymphoblastic Leukemia / B Acute Lymphoblastic Leukemia, Philadelphia Chromosome Negative / BCR/ABL1 Fusion Protein Negative / Untreated Adult Acute Lymphoblastic Leukemia1
3Active Not RecruitingTreatmentAcute Lymphoblastic Leukaemias (ALL) / B Acute Lymphoblastic Leukemia / Central Nervous System Leukemia / Cognitive Side Effects of Cancer Therapy / Neurotoxicity Syndrome / Osteonecrosis / Pain / Ph-Like Acute Lymphoblastic Leukemia / Testicular Leukemia / Therapy-Related Toxicity / Untreated Adult Acute Lymphoblastic Leukemia / Untreated Childhood Acute Lymphoblastic Leukemia1
3Active Not RecruitingTreatmentAdenocarcinoma of the Prostate / Hormone-Resistant Prostate Cancer / Recurrent Prostate Cancer / Stage IV Prostate Cancer1
3Active Not RecruitingTreatmentAnaplastic Large-Cell Lymphoma / Lymphoma, Large-Cell, Anaplastic / Non-Hodgkin's Lymphoma (NHL) / T-Cell Lymphomas1
3Active Not RecruitingTreatmentAnn Arbor Stage IIB Hodgkin Lymphoma / Ann Arbor Stage IIIB Hodgkin Lymphoma / Ann Arbor Stage IV Hodgkin Lymphoma / Ann Arbor Stage IVA Hodgkin Lymphoma / Ann Arbor Stage IVB Hodgkin Lymphoma / Childhood Hodgkin Lymphoma / Classic Hodgkin Lymphoma / Classical Hodgkin Lymphoma / Stage IIB Hodgkin Lymphoma / Stage IIIB Hodgkin Lymphoma / Stage IV Hodgkin Lymphoma / Stage IVA Hodgkin Lymphoma / Stage IVB Hodgkin Lymphoma1
3Active Not RecruitingTreatmentAsthma1
3Active Not RecruitingTreatmentB-cell Childhood Acute Lymphoblastic Leukemia / Intermediate Risk Recurrent Childhood Acute Lymphoblastic Leukemia / L1 Childhood Acute Lymphoblastic Leukemia / L2 Childhood Acute Lymphoblastic Leukemia1
3Active Not RecruitingTreatmentChildhood Favorable Prognosis Hodgkin Lymphoma / Childhood Lymphocyte Depletion Hodgkin Lymphoma / Childhood Mixed Cellularity Hodgkin Lymphoma / Childhood Nodular Sclerosis Hodgkin Lymphoma / Stage I Childhood Hodgkin Lymphoma / Stage II Childhood Hodgkin Lymphoma1
3Active Not RecruitingTreatmentChildhood Nodular Lymphocyte Predominant Hodgkin Lymphoma / Stage III Childhood Hodgkin Lymphoma / Stage IV Childhood Hodgkin Lymphoma1
3Active Not RecruitingTreatmentChronic Graft Versus Host Disease1
3Active Not RecruitingTreatmentDuchenne's Muscular Dystrophy (DMD)1
3Active Not RecruitingTreatmentFailing Renal Allograft / Transplant, Kidney1
3Active Not RecruitingTreatmentFollicular Lymphoma (FL) / Lymphoplasmacytic Lymphoma / Marginal Zone Lymphoma / Small Lymphocytic Lymphoma1
3Active Not RecruitingTreatmentFollicular Non-Hodgkin's Lymphoma1
3Active Not RecruitingTreatmentGeneral Surgery / Stage, Prostate Cancer1
3Active Not RecruitingTreatmentLarge B Cell Lymphoma1
3Active Not RecruitingTreatmentLeukemias1
3Active Not RecruitingTreatmentLymphoma, Hodgkins2
3Active Not RecruitingTreatmentLymphoma, Large B-Cell, Diffuse (DLBCL)1
3Active Not RecruitingTreatmentMalignant Lymphomas8
3Active Not RecruitingTreatmentMalignant Lymphomas / Non-Hodgkin's Lymphoma (NHL)1
3Active Not RecruitingTreatmentMantle Cell Lymphoma (MCL)2
3Active Not RecruitingTreatmentMetastatic Breast Cancer / Metastatic Castration Resistant Prostate Cancer1
3Active Not RecruitingTreatmentMultiple Myeloma (MM)3
3Active Not RecruitingTreatmentMultiple Myeloma (MM) / Newly Diagnosed Patients1
3Active Not RecruitingTreatmentNon-Hodgkin's Lymphoma (NHL)1
3Active Not RecruitingTreatmentPlasma Cell Myeloma / Stage I Multiple Myeloma / Stage II Multiple Myeloma / Stage III Multiple Myeloma1
3Active Not RecruitingTreatmentProstate Cancer2
3Active Not RecruitingTreatmentProstate Neoplasms1
3Active Not RecruitingTreatmentProstatic Neoplasms2
3Active Not RecruitingTreatmentThrombotic Thrombocytopenic Purpura (TTP)1
3CompletedPreventionChronic Renal Failure (CRF)1
3CompletedPreventionHuman Immunodeficiency Virus (HIV) / Immune Reconstitution Inflammatory Syndrome / Tuberculosis Infection1
3CompletedPreventionPediatric Kidney Transplantation1
3CompletedSupportive CareCardiac Toxicity / Leukemias / Malignant Lymphomas1
3CompletedSupportive CareGraft Versus Host Disease (GVHD)2
3CompletedSupportive CareGraft Versus Host Disease (GVHD) / Recurrent Adult Acute Lymphoblastic Leukemia1
3CompletedTreatmentANCA-Associated Vasculitis (AAV)1
3CompletedTreatmentAcute Lymphoblastic Leukaemias (ALL)2
3CompletedTreatmentAcute Lymphoblastic Leukaemias (ALL) / Acute Undifferentiated Leukemia (AUL) / Childhood T Acute Lymphoblastic Leukemia / T-cell Childhood Acute Lymphoblastic Leukemia / Untreated Childhood Acute Lymphoblastic Leukemia1
3CompletedTreatmentAcute Lymphoblastic Leukaemias (ALL) / Adult T Acute Lymphoblastic Leukemia / Ann Arbor Stage II Adult T-Cell Leukemia/Lymphoma / Ann Arbor Stage II Childhood Lymphoblastic Lymphoma / Ann Arbor Stage II Contiguous Adult Lymphoblastic Lymphoma / Ann Arbor Stage II Non-Contiguous Adult Lymphoblastic Lymphoma / Ann Arbor Stage III Adult Lymphoblastic Lymphoma / Ann Arbor Stage III Adult T-Cell Leukemia/Lymphoma / Ann Arbor Stage III Childhood Lymphoblastic Lymphoma / Ann Arbor Stage IV Adult Lymphoblastic Lymphoma / Ann Arbor Stage IV Adult T-Cell Leukemia/Lymphoma / Ann Arbor Stage IV Childhood Lymphoblastic Lymphoma / Childhood T Acute Lymphoblastic Leukemia / Stage II Adult T-Cell Leukemia/Lymphoma / Stage II Childhood Lymphoblastic Lymphoma / Stage II Contiguous Adult Lymphoblastic Lymphoma / Stage II Non-Contiguous Adult Lymphoblastic Lymphoma / Stage III Adult Lymphoblastic Lymphoma / Stage III Adult T-Cell Leukemia/Lymphoma / Stage III Childhood Lymphoblastic Lymphoma / Stage IV Adult Lymphoblastic Lymphoma / Stage IV Adult T-Cell Leukemia/Lymphoma / Stage IV Childhood Lymphoblastic Lymphoma / T Acute Lymphoblastic Leukemia / T Lymphoblastic Lymphoma / Untreated Adult Acute Lymphoblastic Leukemia / Untreated Childhood Acute Lymphoblastic Leukemia1
3CompletedTreatmentAdenocarcinoma of the Prostate / Hormone-Resistant Prostate Cancer / Recurrent Prostate Cancer / Stage IV Prostate Cancer1
3CompletedTreatmentAdvanced Hodgkin Disease1
3CompletedTreatmentAllergies / Conjunctivitis / Rhinitis / Rhinoconjunctivitis2
3CompletedTreatmentAlzheimer's Disease (AD)1
3CompletedTreatmentAsthma6
3CompletedTreatmentCardiac Toxicity / Malignant Lymphomas1
3CompletedTreatmentCastration Resistant Prostate Cancer (CRPC) / Pain / Prostate Cancer / Prostatic Neoplasms1
3CompletedTreatmentChildhood Lymphocyte-Depleted Classical Hodgkin Lymphoma / Childhood Mixed Cellularity Classical Hodgkin Lymphoma / Childhood Nodular Lymphocyte Predominant Hodgkin Lymphoma / Childhood Nodular Sclerosis Classical Hodgkin Lymphoma / Malignant Lymphomas / Stage I Childhood Hodgkin Lymphoma / Stage II Childhood Hodgkin Lymphoma / Stage III Childhood Hodgkin Lymphoma / Stage IV Childhood Hodgkin Lymphoma1
3CompletedTreatmentChronic Kidney Disease (CKD) / IgA Nephropathy1
3CompletedTreatmentChronic Obstructive Pulmonary Disease (COPD)1
3CompletedTreatmentChronic Rhinosinusitis With Polyposis1
3CompletedTreatmentCommunity Acquired Pneumonia (CAP)1
3CompletedTreatmentCongenital Adrenal Hyperplasia (CAH)1
3CompletedTreatmentCrohn's Disease (CD)1
3CompletedTreatmentDemyelinating Polyneuropathy1
3CompletedTreatmentDermatomyositis / Polymyositis1
3CompletedTreatmentDiffuse Large B-Cell Lymphoma, Non-Hodgkin's Lymphoma1
3CompletedTreatmentDisseminated Neuroblastoma / Localized Resectable Neuroblastoma / Localized Unresectable Neuroblastoma / Regional Neuroblastoma / Stage 4S Neuroblastoma1
3CompletedTreatmentDuchenne's Muscular Dystrophy (DMD)2
3CompletedTreatmentElderly Patients (>65 Years) / Lymphoma, Large B-Cell, Diffuse (DLBCL)1
3CompletedTreatmentFollicular Lymphoma (FL)1
3CompletedTreatmentFollicular Lymphoma (FL) / Immunocytomas / Lymphocytic Lymphomas / Marginal Zone Lymphomas / Non-Hodgkin's Lymphoma (NHL)1
3CompletedTreatmentGiant Cells Arteritis1
3CompletedTreatmentHeart Diseases / Heart Transplantation1
3CompletedTreatmentHeart Failure1
3CompletedTreatmentHormone Refractory Prostate Cancer / Prostate Cancer1
3CompletedTreatmentHuman Immunodeficiency Virus (HIV) Infections / Tuberculosis Infection1
3CompletedTreatmentHypereosinophilic Syndromes1
3CompletedTreatmentIdiopathic Thrombocytopenic Purpura1
3CompletedTreatmentIgA Nephropathy1
3CompletedTreatmentKidney Diseases2
3CompletedTreatmentLeukemia, Myelocytic, Acute1
3CompletedTreatmentLeukemias8
3CompletedTreatmentLeukemias / Malignant Lymphomas3
3CompletedTreatmentLymphoma, High-Grade1
3CompletedTreatmentLymphoma, Hodgkins3
3CompletedTreatmentLymphoma, Large B-Cell, Diffuse (DLBCL)3
3CompletedTreatmentMalignant Lymphomas19
3CompletedTreatmentMantle Cell Lymphoma (MCL) / Non-Hodgkin's Lymphoma (NHL)1
3CompletedTreatmentMetastatic Cancers / Prostate Cancer1
3CompletedTreatmentMetastatic Castration Resistant Prostate Cancer1
3CompletedTreatmentMultiple Myeloma (MM)6
3CompletedTreatmentMultiple Myeloma and Plasma Cell Neoplasm2
3CompletedTreatmentMyasthenia Gravis1
3CompletedTreatmentNeoplasms Metastasis / Prostatic Neoplasms1
3CompletedTreatmentNeoplasms / Prostatic Neoplasms1
3CompletedTreatmentNephritis, Lupus3
3CompletedTreatmentNephrotic Syndrome1
3CompletedTreatmentNewly Diagnosed Multiple Myeloma1
3CompletedTreatmentNon-Hodgkin's Lymphoma (NHL)2
3CompletedTreatmentNonneoplastic Condition1
3CompletedTreatmentOrgan Transplantation, Renal Transplantation1
3CompletedTreatmentPain / Prostate Cancer / Quality of Life1
3CompletedTreatmentPerennial Allergic Rhinitis (PAR)1
3CompletedTreatmentPneumonia1
3CompletedTreatmentPolyps, Nasal1
3CompletedTreatmentProstate Cancer13
3CompletedTreatmentProstate Neoplasms2
3CompletedTreatmentProstatic Neoplasms3
3CompletedTreatmentRheumatoid Arthritis2
3CompletedTreatmentSarcoidosis, Pulmonary1
3CompletedTreatmentSciatica1
3CompletedTreatmentSickle Cell Disorders / Vaso-occlusive Crisis1
3CompletedTreatmentStage I Multiple Myeloma / Stage II Multiple Myeloma / Stage III Multiple Myeloma1
3CompletedTreatmentStage III Grade 1 Follicular Lymphoma / Stage III Grade 2 Follicular Lymphoma / Stage III Grade 3 Follicular Lymphoma / Stage III Small Lymphocytic Lymphoma / Stage IV Grade 1 Follicular Lymphoma / Stage IV Grade 2 Follicular Lymphoma / Stage IV Grade 3 Follicular Lymphoma / Stage IV Small Lymphocytic Lymphoma1
3CompletedTreatmentSudden Deafness1
3CompletedTreatmentTransplantation, Kidney2
3CompletedTreatmentTransplantation, Renal1
3CompletedTreatmentUveitis3
3No Longer AvailableNot AvailableMultiple Myeloma (MM)1
3Not Yet RecruitingPreventionTransplantation, Liver1
3Not Yet RecruitingTreatmentAdenocarcinoma, Prostate / Positive Lymph Node / PSA Level Greater Than Zero / Stage I Prostate Cancer AJCC v8 / Stage II Prostate Cancer AJCC v8 / Stage IIA Prostate Cancer AJCC v8 / Stage IIB Prostate Cancer AJCC v8 / Stage IIC Prostate Cancer AJCC v8 / Stage III Prostate Cancer AJCC v8 / Stage IIIA Prostate Cancer AJCC v8 / Stage IIIB Prostate Cancer AJCC v8 / Stage IIIC Prostate Cancer AJCC v8 / Stage IVA Prostate Cancer AJCC v81
3Not Yet RecruitingTreatmentDiffuse Large B-Cell Lymphoma, Unspecified Site1
3Not Yet RecruitingTreatmentGiant Cells Arteritis / Patients Diagnosed of Giant-cell Arteritis1
3Not Yet RecruitingTreatmentPeripheral T Cell Lymphoma (PTCL)1
3Not Yet RecruitingTreatmentPeripheral T-Cell Lymphoma (PTCL)1
3Not Yet RecruitingTreatmentProstate Cancer1
3RecruitingOtherAsthma1
3RecruitingTreatmentAcute Lymphoblastic Leukaemias (ALL) / Acute Lymphocytic Leukemia (ALL) / Leukaemia, Lymphoblastic / Leukemia, Lymphoblastic, Acute, Philadelphia-Positive / Lymphoblastic Leukemia, Acute, Adult / Ph1 Chromosome1
3RecruitingTreatmentAcute Lymphoblastic Leukaemias (ALL) / B Acute Lymphoblastic Leukemia / B Acute Lymphoblastic Leukemia With t(9;22)(q34.1;q11.2); BCR-ABL1 / BCR-ABL1 Fusion Protein Expression / Minimal Residual Disease / Philadelphia Chromosome Positive / T Acute Lymphoblastic Leukemia / Untreated Adult Acute Lymphoblastic Leukemia / Untreated Childhood Acute Lymphoblastic Leukemia1
3RecruitingTreatmentAcute Lymphoblastic Leukemia, Pediatric1
3RecruitingTreatmentAdult Immune Thrombocytopenia (ITP) / Dapsone1
3RecruitingTreatmentAsthma2
3RecruitingTreatmentB Acute Lymphoblastic Leukemia / B Lymphoblastic Lymphoma / Blasts More Than 25 Percent of Bone Marrow Nucleated Cells / Central Nervous System Leukemia / Mixed Phenotype Acute Leukemia (MPAL) / Testicular Leukemia1
3RecruitingTreatmentB Acute Lymphoblastic Leukemia / B Lymphoblastic Lymphoma / Blasts More Than 25 Percent of Bone Marrow Nucleated Cells / Down Syndrome (DS)1
3RecruitingTreatmentB Acute Lymphoblastic Leukemia / Central Nervous System Leukemia / Cognitive Side Effects of Cancer Therapy / Neurotoxicity Syndrome / Osteonecrosis / Pain / Testicular Leukemia / Therapy-Related Toxicity / Untreated Adult Acute Lymphoblastic Leukemia / Untreated Childhood Acute Lymphoblastic Leukemia1
3RecruitingTreatmentCardiac Sarcoidosis / Sarcoidosis1
3RecruitingTreatmentCastration Levels of Testosterone / Metastatic Prostatic Adenocarcinoma / Stage IV Prostate Cancer AJCC v8 / Stage IVA Prostate Cancer AJCC v8 / Stage IVB Prostate Cancer AJCC v81
3RecruitingTreatmentChondrocalcinosis pyrophosphate1
3RecruitingTreatmentChronic Graft Versus Host Disease1
3RecruitingTreatmentChronic Inflammation / Cognitive Impairments / Fatigue / Pain, Chronic1
3RecruitingTreatmentChronic Rhinosinusitis / Sinusitis1
3RecruitingTreatmentClassical Hodgkin Lymphoma2
3RecruitingTreatmentCystic Fibrosis Pulmonary Exacerbation1
3RecruitingTreatmentFollicular Lymphoma (FL)1
3RecruitingTreatmentGiant Cells Arteritis1
3RecruitingTreatmentGlomerulosclerosis, Focal Segmental / Idiopathic Nephrotic Syndrome / Nephrotic Syndrome1
3RecruitingTreatmentGranulomatosis With Polyangiitis1
3RecruitingTreatmentGranulomatosis With Polyangiitis / Vasculitis1
3RecruitingTreatmentLangerhans Cell Histiocytosis (LCH)1
3RecruitingTreatmentLymphoblastic Lymphoma, Childhood1
3RecruitingTreatmentLymphoma, Large B-Cell, Diffuse (DLBCL)8
3RecruitingTreatmentLymphoma, Lymphoblastic1
3RecruitingTreatmentMalignant Lymphomas1
3RecruitingTreatmentMantle Cell Lymphoma (MCL)2
3RecruitingTreatmentMetastatic Castrate Resistant Prostate Cancer1
3RecruitingTreatmentMetastatic Hormone Refractory Prostate Cancer2
3RecruitingTreatmentMultiple Myeloma (MM)1
3RecruitingTreatmentNephrotic Syndrome1
3RecruitingTreatmentNewly Diagnosed Multiple Myeloma1
3RecruitingTreatmentNon-Hodgkin's Lymphoma (NHL)1
3RecruitingTreatmentPeripheral T-Cell Lymphoma (PTCL)1
3RecruitingTreatmentPolymyalgia Rheumatica1
3RecruitingTreatmentProstate Cancer2
3RecruitingTreatmentProstatic Neoplasms2
3RecruitingTreatmentSystemic Lupus Erythematosus (SLE)1
3RecruitingTreatmentThalidomide1
3RecruitingTreatmentUlcerative Colitis1
3RecruitingTreatmentVasculitis1
3SuspendedTreatmentCongenital Adrenal Hyperplasia (CAH)1
3SuspendedTreatmentMalignant Lymphomas1
3TerminatedHealth Services ResearchFollicular Lymphoma (FL)1
3TerminatedTreatmentANCA Associated Systemic Vasculitis Including Wegener’s / Granulomatosis and Microscopic Polyangiitis and / Renal Limited Vasculitis1
3TerminatedTreatmentAcute Lymphoblastic Leukaemias (ALL)1
3TerminatedTreatmentAtherosclerosis / Renal Failure1
3TerminatedTreatmentCastrate-resistant Prostate Cancer (CRPC) / Hormone Refractory Prostate Cancer1
3TerminatedTreatmentCastration Resistant Prostate Cancer (CRPC) / Pain / Prostate Cancer / Prostatic Neoplasms1
3TerminatedTreatmentDiffuse Large B Cell Lymphoma CD20 Positive / Diffuse Large B Cell Lymphoma CD20+1
3TerminatedTreatmentDuchenne's Muscular Dystrophy (DMD)1
3TerminatedTreatmentGiant Cells Arteritis1
3TerminatedTreatmentGraft Versus Host Disease (GVHD)1
3TerminatedTreatmentImmune Thrombocytopenic Purpura ( ITP )1
3TerminatedTreatmentLymphoma, B Cell1
3TerminatedTreatmentLymphoma, B-Cell / Lymphoma, Large B-Cell, Diffuse (DLBCL)1
3TerminatedTreatmentLymphoma, Extranodal NK-T-Cell1
3TerminatedTreatmentLymphoma, Large-Cell, Diffuse1
3TerminatedTreatmentMalignant Lymphomas1
3TerminatedTreatmentNephritis, Lupus2
3TerminatedTreatmentNewly Diagnosed, Multiple Myeloma1
3TerminatedTreatmentOcular Myasthenia Gravis1
3TerminatedTreatmentPemphigus1
3TerminatedTreatmentPolymyalgia Rheumatica1
3TerminatedTreatmentProstate Cancer3
3TerminatedTreatmentProstatic Neoplasms2
3Unknown StatusTreatmentBrain and Central Nervous System Tumors1
3Unknown StatusTreatmentChronic Periaortitis / Idiopathic Retroperitoneal Fibrosis / Perianeurysmal Retroperitoneal Fibrosis1
3Unknown StatusTreatmentDisseminated Sclerosis / Optic Neuritis1
3Unknown StatusTreatmentFollicular Lymphoma (FL)1
3Unknown StatusTreatmentIPI≥2 / Lymphoma, Large B-Cell, Diffuse (DLBCL)1
3Unknown StatusTreatmentInflammatory Cardiomyopathy1
3Unknown StatusTreatmentLeukemias1
3Unknown StatusTreatmentMalignant Lymphomas7
3Unknown StatusTreatmentMantle Cell Lymphoma (MCL)1
3Unknown StatusTreatmentMultiple Myeloma (MM)1
3Unknown StatusTreatmentMultiple Myeloma and Plasma Cell Neoplasm3
3WithdrawnTreatmentAnemias / Hyper-reactive Malarial Splenomegaly / Plasmodium Infections1
3WithdrawnTreatmentLeukemias1
3WithdrawnTreatmentLymphoma, Large B-Cell, Diffuse (DLBCL)1
4Active Not RecruitingBasic ScienceChronic Obstructive Pulmonary Disease (COPD)1
4Active Not RecruitingPreventionAsthma / Upper Respiratory Tract Infection1
4Active Not RecruitingPreventionEnd-Stage Renal Disease (ESRD)1
4Active Not RecruitingTreatmentALK-negative Anaplastic Large Cell Lymphoma / Angioimmunoblastic T Cell Lymphoma / Enteropathy Associated T Cell Lymphoma / Hepatosplenic T Cell Lymphoma / Peripherial T Cell Lymphoma,Not Otherwise Specified / Subcutaneous Panniculitis Like T Cell Lymphoma1
4Active Not RecruitingTreatmentAcute Lymphoblastic Leukaemias (ALL)1
4Active Not RecruitingTreatmentCytomegalovirus / Transplantation, Kidney1
4Active Not RecruitingTreatmentFatigue / Lupus Erythematosus / Systemic Lupus Erythematosus (SLE)1
4Active Not RecruitingTreatmentIgA Nephropathy1
4Active Not RecruitingTreatmentImmunosuppression1
4Active Not RecruitingTreatmentKidney Transplant Rejection / Other Complications of Kidney Transplant1
4Active Not RecruitingTreatmentMetastatic Hormone Refractory Prostate Cancer1
4Active Not RecruitingTreatmentProstate Cancer1
4Active Not RecruitingTreatmentTransplantation, Renal1
4CompletedNot AvailableInflammatory Bowel Disease 111
4CompletedNot AvailableMultiple Myeloma (MM)1
4CompletedBasic ScienceBrown Adipose Tissue1
4CompletedDiagnosticAdrenal Gland Hypofunction1
4CompletedPreventionAdverse Effects / Transplantation, Kidney1
4CompletedPreventionEsophageal Strictures1
4CompletedPreventionInfections, Cytomegalovirus / Transplantation Infection1
4CompletedPreventionTransplantation, Kidney2
4CompletedPreventionTransplantation, Liver1
4CompletedTreatmentAcute Lymphoblastic Leukaemias (ALL)4
4CompletedTreatmentAsthma1
4CompletedTreatmentAsthma / Asthma Acute / Reactive Airway Exacerbation1
4CompletedTreatmentAsthma / Reactive Airways Disease (RAD)1
4CompletedTreatmentBullous Pemphigoid (BP)1
4CompletedTreatmentChronic Kidney Disease (CKD) / End Stage Renal Disease (ESRD) / Hemodialysis Treatment / Renal Replacement Therapies / Transplantation, Renal1
4CompletedTreatmentChronic Kidney Disease (CKD) / Transplantation, Kidney1
4CompletedTreatmentChronic Obstructive (MeSH) / Pulmonary Diseases1
4CompletedTreatmentChronic Obstructive Pulmonary Disease (COPD)1
4CompletedTreatmentChronic Renal Failure (CRF) / Renal Insufficiency,Chronic / Transplantation, Kidney1
4CompletedTreatmentChurg-Strauss Syndrome (CSS) / Granulomatosis With Polyangiitis / Microscopic Polyangiitis / Polyarteritis Nodosa / Vasculitis1
4CompletedTreatmentComparative Study / Immunosuppressive Agents1
4CompletedTreatmentCroup1
4CompletedTreatmentDisorder Related to Renal Transplantation / Infections, Cytomegalovirus1
4CompletedTreatmentGraft Versus Host Disease (GVHD) / Renal Failure1
4CompletedTreatmentGranulomatosis With Polyangiitis / Microscopic Polyangiitis1
4CompletedTreatmentHeart Failure / Hyperuricemia1
4CompletedTreatmentHenoch Schönlein Purpura1
4CompletedTreatmentHenoch-Schoenlein Purpura Nephritis1
4CompletedTreatmentHepatitis, Autoimmune1
4CompletedTreatmentHuman Immunodeficiency Virus (HIV) Infections1
4CompletedTreatmentHuman Immunodeficiency Virus (HIV) Infections / Lymphoma, Large B-Cell, Diffuse (DLBCL)1
4CompletedTreatmentIdiopathic Thrombocytopenic Purpura1
4CompletedTreatmentImmunoglobulin G4 Related Sclerosing Disease1
4CompletedTreatmentJuvenile Chronic Polyarthritis / Juvenile Idiopathic Arthritis (JIA) / Rheumatoid Arthritis, Juvenile1
4CompletedTreatmentKidney Diseases1
4CompletedTreatmentLiver Cirrhosis / Liver Transplant Disorder1
4CompletedTreatmentMetastatic Hormone Refractory Prostate Cancer1
4CompletedTreatmentMyasthenia Gravis1
4CompletedTreatmentPeripheral T-Cell Lymphoma (PTCL)1
4CompletedTreatmentPolymyalgia Rheumatica1
4CompletedTreatmentProstate Cancer1
4CompletedTreatmentRenal Transplant Recipient Patients1
4CompletedTreatmentRheumatoid Arthritis4
4CompletedTreatmentSevere Alcoholic Hepatitis1
4CompletedTreatmentTransplantation, Kidney2
4CompletedTreatmentTransplantation, Liver1
4CompletedTreatmentTransplantation, Renal1
4CompletedTreatmentUlcerative Colitis1
4CompletedTreatmentNon-suppurative Thyroiditis1
4Enrolling by InvitationBasic ScienceRheumatoid Arthritis1
4Enrolling by InvitationTreatmentAchalasia1
4Enrolling by InvitationTreatmentEfficacy and Safety / Mycophenolate Mofetil / Neuromyelitis Optica Spectrum Disorders1
4Not Yet RecruitingDiagnosticImmunosuppression / Kidney Transplant Rejection1
4Not Yet RecruitingTreatmentIgA Glomerulonephritis / Renal Insufficiency,Chronic1
4Not Yet RecruitingTreatmentInterstitial Lung Disease (ILD) / Lung neoplasm malignant1
4Not Yet RecruitingTreatmentNephrotic Syndrome, Minimal Change1
4Not Yet RecruitingTreatmentPneumonia Hospital Acquired1
4Not Yet RecruitingTreatmentSjögren's Syndrome1
4Not Yet RecruitingTreatmentPh+ Acute Lymphoblastic Leukemia1
4RecruitingOtherUlcerative Colitis1
4RecruitingPreventionConnective Tissue Diseases / Long qt Syndrome / Rheumatoid Arthritis1
4RecruitingPreventionDisseminated Sclerosis1
4RecruitingSupportive CareCastration-Resistant Prostatic Cancer / Hormone-Refractory Prostate Cancer / Metastatic Hormone Refractory Prostate Cancer / Recurrent Prostate Carcinoma / Stage IV Prostate Cancer1
4RecruitingSupportive CareRheumatoid Arthritis1
4RecruitingTreatmentAcute Lymphobkastic Leukemia1
4RecruitingTreatmentAdhesive Capsulitis / Adhesive Capsulitis of Shoulder / Adhesive Capsulitis of Unspecified Shoulder1
4RecruitingTreatmentAdvanced Follicular Lymphoma1
4RecruitingTreatmentAutoimmune / Inflammatory Disorder1
4RecruitingTreatmentChronic Obstructive Pulmonary Disease (COPD)1
4RecruitingTreatmentChronic Obstructive Pulmonary Disease (COPD) / Heart Failure1
4RecruitingTreatmentChronic Renal Failure (CRF) / Graft Failure / Kidney Transplant Rejection / Transplant; Failure, Kidney1
4RecruitingTreatmentChronic Rhinosinusitis Without Nasal Polyps1
4RecruitingTreatmentCongenital Adrenal Hyperplasia (CAH)1
4RecruitingTreatmentCopd Exacerbation Acute / Ventilations, Mechanical1
4RecruitingTreatmentCrohn's Disease (CD)2
4RecruitingTreatmentEosinophilia / Hematologic Diseases / Hypereosinophilia / Leukocyte Disorders1
4RecruitingTreatmentGiant Cells Arteritis1
4RecruitingTreatmentHemophilia A With Inhibitors1
4RecruitingTreatmentImmunosuppression / Transplantation, Kidney1
4RecruitingTreatmentKidney Transplant Patients1
4RecruitingTreatmentLymphoma, Large B-Cell, Diffuse (DLBCL)3
4RecruitingTreatmentMantle Cell Lymphoma (MCL)1
4RecruitingTreatmentMultiple Myeloma (MM)2
4RecruitingTreatmentNephrotic Syndrome1
4RecruitingTreatmentNewly Diagnosed Peripheral T-cell Lymphoma1
4RecruitingTreatmentNon-Hodgkin's Lymphoma (NHL)1
4RecruitingTreatmentRecurrent Pregnancy Losses1
4RecruitingTreatmentRheumatoid Arthritis1
4RecruitingTreatmentWegener's Granulomatosis or Microscopic Polyangiitis / Wegener's Granulomatosis, Microscopic Polyangiitis1
4TerminatedTreatmentAcute Adrenal Insufficiency / Shock, Septic1
4TerminatedTreatmentAcute maxillary sinusitis caused by M. catarrhalis / Chronic Rhinosinusitis / Polyps, Nasal1
4TerminatedTreatmentAsthma / Status Asthmaticus / Wheezing1
4TerminatedTreatmentCrohn's Disease (CD)1
4TerminatedTreatmentCrohn's Disease (CD) / Inflammatory Bowel Diseases (IBD)1
4TerminatedTreatmentDisseminated Sclerosis1
4TerminatedTreatmentRelapsing Remitting Multiple Sclerosis (RRMS)1
4TerminatedTreatmentTransplantation, Kidney1
4TerminatedTreatmentTransplants and Implants1
4Unknown StatusNot AvailableKidney Diseases1
4Unknown StatusPreventionDiabetes Mellitus (DM) / Rejection, Transplant1
4Unknown StatusPreventionDisorder Related to Renal Transplantation1
4Unknown StatusTreatmentAcute Lymphoblastic Leukaemias (ALL) / Non-Hodgkin's Lymphoma (NHL)1
4Unknown StatusTreatmentAsthma1
4Unknown StatusTreatmentCrohn's Disease (CD)1
4Unknown StatusTreatmentEndocrine ophthalmopathy1
4Unknown StatusTreatmentGiant Cells Arteritis1
4Unknown StatusTreatmentGlomerular Diseases1
4Unknown StatusTreatmentInfections, Cytomegalovirus1
4Unknown StatusTreatmentPituitary Neoplasms / Postsurgical craniopharyngioma1
4WithdrawnNot AvailableProstate Neoplasms1
4WithdrawnTreatmentAcute Cellular Graft Rejection / Liver Transplant Rejection1
4WithdrawnTreatmentAntibody Mediated Rejection / End Stage Renal Disease (ESRD)1
4WithdrawnTreatmentCardiac Sarcoidosis / Sarcoidosis1
4WithdrawnTreatmentCardiovascular Heart Disease / Cardiovascular Outcomes / Renal Transplant Recipient Patients / Transplantation, Kidney1
4WithdrawnTreatmentChronic Rhinosinusitis Without Nasal Polyps (CRSsNP)1
4WithdrawnTreatmentPneumonia, Pneumocystis Carinii1
Not AvailableActive Not RecruitingTreatmentChildhood Acute Lymphoblastic Leukemia1
Not AvailableActive Not RecruitingTreatmentChildhood Lymphocyte Predominant Hodgkin Lymphoma / Stage I Childhood Hodgkin Lymphoma / Stage II Childhood Hodgkin Lymphoma1
Not AvailableActive Not RecruitingTreatmentEnd-Stage Renal Disease (ESRD)1
Not AvailableActive Not RecruitingTreatmentNephrotic Syndrome,Idiopathic1
Not AvailableActive Not RecruitingTreatmentProstate Cancer1
Not AvailableApproved for MarketingNot AvailableGenital Diseases, Male / Genital Neoplasms, Male / Genitourinary tract neoplasm / Prostate Neoplasms1
Not AvailableCompletedNot AvailableCrohn's Disease (CD) / Inflammatory Bowel Diseases (IBD)1
Not AvailableCompletedNot AvailableDermatomyositis / Polymyositis1
Not AvailableCompletedNot AvailableInflammatory Bowel Diseases (IBD)1
Not AvailableCompletedNot AvailableLymphoma, Lymphoma, Large B-Cell, Diffuse, Non-Hodgkin's Lymphoma, Lymphoma, Non Hodgkin, Relapsed or Refractory Diffuse Large B-Cell Lymphoma1
Not AvailableCompletedNot AvailablePediatric Heart Transplant Recipients / Pediatric Heart Transplantation1
Not AvailableCompletedNot AvailableRheumatoid Arthritis2
Not AvailableCompletedDiagnosticAsthma1
Not AvailableCompletedOtherChoroid Disease / Inflammatory Reaction / Uveomeningoencephalitic Syndrome / Visual Impairment1
Not AvailableCompletedPreventionEsophageal Strictures1
Not AvailableCompletedTreatmentAtaxia-Telangiectasia1
Not AvailableCompletedTreatmentAtrial Fibrillation (AF)1
Not AvailableCompletedTreatmentB-cell Adult Acute Lymphoblastic Leukemia / B-cell Childhood Acute Lymphoblastic Leukemia / Untreated Adult Acute Lymphoblastic Leukemia / Untreated Childhood Acute Lymphoblastic Leukemia2
Not AvailableCompletedTreatmentBell's Palsy2
Not AvailableCompletedTreatmentBlood and Marrow Transplant (BMT) / Graft Versus Host Disease (GVHD)1
Not AvailableCompletedTreatmentChronic Rhinosinusitis / Chronic Rhinosinusitis Without Polyps / Endoscopic Sinus Surgery / Oral Steroids1
Not AvailableCompletedTreatmentChronic Rhinosinusitis / Nasal Polyposis1
Not AvailableCompletedTreatmentEnd-Stage Renal Disease (ESRD)1
Not AvailableCompletedTreatmentHemangiomas1
Not AvailableCompletedTreatmentIdiopathic Membranous Nephropathy1
Not AvailableCompletedTreatmentIgA Nephropathy1
Not AvailableCompletedTreatmentIgA Nephropathy (IgAN)1
Not AvailableCompletedTreatmentImmunosuppression1
Not AvailableCompletedTreatmentL1 Childhood Acute Lymphoblastic Leukemia / L2 Childhood Acute Lymphoblastic Leukemia / Non-T, Non-B Childhood Acute Lymphoblastic Leukemia / Recurrent Childhood Acute Lymphoblastic Leukemia / T-cell Childhood Acute Lymphoblastic Leukemia1
Not AvailableCompletedTreatmentLeukemias2
Not AvailableCompletedTreatmentLeukopenia / Men Infertility / Oxidative Stress / Postinfection Inflammation1
Not AvailableCompletedTreatmentLymphoma, Hodgkins1
Not AvailableCompletedTreatmentLymphoma, Large B-Cell, Diffuse (DLBCL)1
Not AvailableCompletedTreatmentLymphoma, Large Cell / Non-Hodgkin's Lymphoma (NHL)1
Not AvailableCompletedTreatmentLymphoma, Lymphoblastic1
Not AvailableCompletedTreatmentMalignant Lymphomas2
Not AvailableCompletedTreatmentPneumonia, Pneumocystis Jerovici1
Not AvailableCompletedTreatmentPost Traumatic Stress Disorder (PTSD)1
Not AvailableCompletedTreatmentSinusitis1
Not AvailableCompletedTreatmentT-cell Childhood Acute Lymphoblastic Leukemia / Untreated Childhood Acute Lymphoblastic Leukemia1
Not AvailableCompletedTreatmentTotal Hip Replacement1
Not AvailableNot Yet RecruitingNot AvailableGlucocorticoid therapy1
Not AvailableNot Yet RecruitingNot AvailableTo Evaluate the Efficacy and Safety of R-EPOCH and R-CHOP Regimen for Patients With AIDS Associated CD20+ Diffuse Large B Lymphoma1
Not AvailableNot Yet RecruitingTreatmentGlucocorticoid therapy / Systemic Lupus Erythematosus (SLE) / Therapy Withdrawal1
Not AvailableNot Yet RecruitingTreatmentIdiopathic Membranous Nephropathy1
Not AvailableNot Yet RecruitingTreatmentPrimary IgA Nephropathy1
Not AvailableNot Yet RecruitingTreatmentSudden hearing loss / Vestibular Vertigo1
Not AvailableRecruitingNot AvailableAcute Lymphoblastic Leukaemias (ALL)1
Not AvailableRecruitingNot AvailableAsthma1
Not AvailableRecruitingNot AvailableBullous Pemphigoid (BP)1
Not AvailableRecruitingNot AvailableChildren / Immunosuppressive Treatment / Nephritis, Lupus / Steroid1
Not AvailableRecruitingNot AvailableDiffuse Large B-Cell / Large B-Cell / Malignant Lymphomas1
Not AvailableRecruitingNot AvailableIgA Nephropathy / Immunosuppressive Treatment / Proteinuria in Nephrotic Range1
Not AvailableRecruitingNot AvailableMyasthenia Gravis1
Not AvailableRecruitingNot AvailableOcular Myasthenia Gravis1
Not AvailableRecruitingDiagnosticSarcoidosis, Pulmonary1
Not AvailableRecruitingOtherDelayed Type Hypersensitivity1
Not AvailableRecruitingPreventionGranulomatosis With Polyangitis / Granulomatosis With Polyangitis and Microscopic Polyangitis / Wegener1
Not AvailableRecruitingTreatmentAdverse Effect of Glucocorticoids and Synthetic Analogues / Chronic Obstructive Pulmonary Disease (COPD) / Disease Exacerbation1
Not AvailableRecruitingTreatmentAutoimmune Diseases1
Not AvailableRecruitingTreatmentClassical Hodgkins Lymphoma in Children and Adolescents1
Not AvailableRecruitingTreatmentClinical Trial / Idiopathic Membranous Nephropathy / Tacrolimus1
Not AvailableRecruitingTreatmentDrug Reaction With Eosinophilia and Systemic Symptoms1
Not AvailableRecruitingTreatmentIdiopathic Membranous Nephropathy1
Not AvailableRecruitingTreatmentLeukemias1
Not AvailableRecruitingTreatmentLymphoma, Large B-Cell, Diffuse (DLBCL)1
Not AvailableRecruitingTreatmentLymphoma, Large B-Cell, Diffuse (DLBCL) / Non-Hodgkin's Lymphoma (NHL)1
Not AvailableRecruitingTreatmentPeripheral T Cell Lymphoma (PTCL)1
Not AvailableRecruitingTreatmentRecurrent Pregnancy Losses / Undifferentiated Connective Tissue Disease1
Not AvailableRecruitingTreatmentSystemic Lupus Erythematosus (SLE)1
Not AvailableTerminatedNot AvailableOsteoporosis1
Not AvailableTerminatedBasic ScienceAtopic Dermatitis (AD)1
Not AvailableTerminatedHealth Services ResearchAsthma / Chronic Obstructive Pulmonary Disease (COPD)1
Not AvailableTerminatedTreatmentBruton's agammaglobulinemia / Chediak-Higashi Syndrome / Chronic Granulomatous Disease (CGD) / Common Variable Immunodeficiency / Familial Erythrophagocytic Lymphohistiocytosis / Graft Versus Host Disease (GVHD) / Immunologic Deficiency Syndromes / Leukocyte Adhesion Deficiency Syndrome / Lymphohistiocytosis, Hemophagocytic / Severe Combined Immunodeficiency / Virus-Associated Hemophagocytic Syndrome / Wiskott-Aldrich Syndrome (WAS) / X-Linked Hyper IgM Syndrome / X-Linked Lymphoproliferative Syndrome1
Not AvailableTerminatedTreatmentContiguous Stage II Adult Diffuse Large Cell Lymphoma / Noncontiguous Stage II Adult Diffuse Large Cell Lymphoma / Stage I Adult Diffuse Large Cell Lymphoma / Stage III Adult Diffuse Large Cell Lymphoma / Stage IV Adult Diffuse Large Cell Lymphoma1
Not AvailableTerminatedTreatmentFollicular Lymphoma (FL) / Malignant Lymphomas / Marginal Zone Lymphoma1
Not AvailableTerminatedTreatmentPolycystic Liver Disease (PLD)1
Not AvailableTerminatedTreatmentT-Cell Lymphomas1
Not AvailableUnknown StatusNot AvailableExacerbation of asthma1
Not AvailableUnknown StatusNot AvailableExercise Performance in Copd Patients1
Not AvailableUnknown StatusNot AvailableHormone Refractory Prostate Cancer1
Not AvailableUnknown StatusNot AvailablePlasma Cell Myeloma1
Not AvailableUnknown StatusSupportive CareCellulitis1
Not AvailableUnknown StatusSupportive CareNon-Hodgkin's Lymphoma (NHL)1
Not AvailableUnknown StatusTreatmentAnemia, Hemolytic, Autoimmune / Autoimmune Thrombocytopenic Purpura / Churg-Strauss Syndrome (CSS) / Giant Cells Arteritis / Graft Versus Host Disease (GVHD) / Granulomatosis With Polyangiitis / Henoch Schönlein Purpura / Polyarteritis Nodosa / Pure Red Cell Aplasia / Rheumatoid Arthritis / Rheumatoid Arthritis, Juvenile / Systemic Lupus Erythematosus (SLE) / Takayasu's Disease / Vasculitis, Hypersensitivity1
Not AvailableUnknown StatusTreatmentDisseminated Sclerosis / Optic Neuritis1
Not AvailableUnknown StatusTreatmentGlomerulosclerosis, Focal Segmental1
Not AvailableUnknown StatusTreatmentIgA Glomerulonephritis1
Not AvailableUnknown StatusTreatmentIgA Nephropathy1
Not AvailableUnknown StatusTreatmentMalignant Lymphomas1
Not AvailableWithdrawnNot AvailableAcute Lymphoblastic Leukaemias (ALL) / Leukemias / Untreated Childhood Acute Lymphoblastic Leukemia1
Not AvailableWithdrawnDiagnosticMalignant Lymphomas1
Not AvailableWithdrawnTreatmentAsthma1
Not AvailableWithdrawnTreatmentHepatitis B Chronic Infection1
Not AvailableWithdrawnTreatmentMalignant Lymphomas1

Pharmacoeconomics

Manufacturers
  • Schering corp sub schering plough corp
  • Roxane laboratories inc
  • Wockhardt eu operations (swiss) ag
  • Muro pharmaceutical inc
  • Halsey drug co inc
  • Bayer pharmaceuticals corp
  • Pharmacia and upjohn co
  • Ferndale laboratories inc
  • Solvay pharmaceuticals
  • Parke davis div warner lambert co
  • Schwarz pharma inc
  • American therapeutics inc
  • Amneal pharmaceuticals ny llc
  • Cm bundy co
  • Cadista pharmaceuticals inc
  • Contract pharmacal corp
  • Duramed pharmaceuticals inc sub barr laboratories inc
  • Elkins sinn div ah robins co inc
  • Everylife
  • John j ferrante
  • Heather drug co inc
  • Impax laboratories inc
  • Inwood laboratories inc sub forest laboratories inc
  • Ivax pharmaceuticals inc sub teva pharmaceuticals usa
  • Kv pharmaceutical co
  • Lannett co inc
  • Lederle laboratories div american cyanamid co
  • Marshall pharmacal corp
  • Mutual pharmaceutical co inc
  • Nylos trading co inc
  • Panray corp sub ormont drug and chemical co inc
  • L perrigo co
  • Pharmavite pharmaceuticals
  • Phoenix laboratories inc
  • Purepac pharmaceutical co
  • Private formulations inc
  • Rexall drug co
  • Sandoz inc
  • Scherer laboratories inc
  • Sperti drug products inc
  • Superpharm corp
  • Teva pharmaceuticals usa inc
  • Udl laboratories inc
  • Upsher smith laboratories inc
  • Valeant pharmaceuticals international
  • Vangard laboratories inc div midway medical co
  • Vintage pharmaceuticals inc
  • Vitarine pharmaceuticals inc
  • Watson laboratories inc
  • West ward pharmaceutical corp
  • Whiteworth towne paulsen inc
Packagers
  • Advanced Pharmaceutical Services Inc.
  • Amend
  • Amerisource Health Services Corp.
  • Apotheca Inc.
  • Apothecary Shop Wholesale
  • AQ Pharmaceuticals Inc.
  • A-S Medication Solutions LLC
  • Breckenridge Pharmaceuticals
  • Bryant Ranch Prepack
  • C.O. Truxton Inc.
  • Cadista Pharmaceuticals Inc.
  • Cardinal Health
  • Carlisle Laboratories Inc.
  • Comprehensive Consultant Services Inc.
  • Corepharma LLC
  • Darby Dental Supply Co. Inc.
  • Dept Health Central Pharmacy
  • Direct Dispensing Inc.
  • Dispensing Solutions
  • Diversified Healthcare Services Inc.
  • H.J. Harkins Co. Inc.
  • Heartland Repack Services LLC
  • Innoviant Pharmacy Inc.
  • Kaiser Foundation Hospital
  • Keltman Pharmaceuticals Inc.
  • Lake Erie Medical and Surgical Supply
  • Liberty Pharmaceuticals
  • Major Pharmaceuticals
  • Mckesson Corp.
  • Merz Pharmaceuticals LLC
  • Murfreesboro Pharmaceutical Nursing Supply
  • Mutual Pharmaceutical Co.
  • Neuman Distributors Inc.
  • Nucare Pharmaceuticals Inc.
  • Palmetto Pharmaceuticals Inc.
  • PCA LLC
  • PD-Rx Pharmaceuticals Inc.
  • Perrigo Co.
  • Pharmacia Inc.
  • Pharmedix
  • Physicians Total Care Inc.
  • Preferred Pharmaceuticals Inc.
  • Prepackage Specialists
  • Prepak Systems Inc.
  • Prescription Dispensing Service Inc.
  • Qualitest
  • Rebel Distributors Corp.
  • Redpharm Drug
  • Remedy Repack
  • Resource Optimization and Innovation LLC
  • Roxane Labs
  • Sandhills Packaging Inc.
  • Southwood Pharmaceuticals
  • St Mary's Medical Park Pharmacy
  • Stat Rx Usa
  • Stat Scripts LLC
  • Tya Pharmaceuticals
  • UDL Laboratories
  • Vangard Labs Inc.
  • Vedco Inc.
  • Veratex Corp.
  • Vintage Pharmaceuticals Inc.
  • Wa Butler Co.
  • Watson Pharmaceuticals
  • West-Ward Pharmaceuticals
Dosage forms
FormRouteStrength
KitOral
TabletOral2.5 mg/1
TabletOral20 mg/20mg
TabletOral5 mg/1
TabletOral
SolutionOral
SolutionOral5 mg/5mL
SolutionOral5 mg/1mL
TabletOral1 mg/1
TabletOral1.0 mg/1
TabletOral10 mg/1
TabletOral10 mg/201
TabletOral20 mg/1
TabletOral20 mg/201
TabletOral5.0 mg/1
TabletOral50 mg/1
Solution, concentrateOral5 mg/1mL
Tablet, delayed releaseOral1 mg/1
Tablet, delayed releaseOral2 mg/1
Tablet, delayed releaseOral5 mg/1
TabletOral
Prices
Unit descriptionCostUnit
Sterapred DS 21 10 mg tablet Disp Pack64.0USD disp
Prednisone powder3.36USD g
Sterapred ds 10 mg tablet unipak2.93USD tablet
Prednisone 5 mg/ml solution1.17USD ml
PredniSONE 5 mg/5ml Solution0.5USD ml
Prednisone 50 mg tablet0.47USD tablet
Prednisone 20 mg tablet0.29USD tablet
Prednisone 10 mg tablet0.27USD tablet
Prednisone 2.5 mg tablet0.25USD tablet
Prednisone 1 mg tablet0.23USD tablet
Apo-Prednisone 50 mg Tablet0.18USD tablet
Winpred 1 mg Tablet0.12USD tablet
Apo-Prednisone 1 mg Tablet0.11USD tablet
Prednisone 5 mg tablet0.08USD tablet
Apo-Prednisone 5 mg Tablet0.04USD tablet
DrugBank does not sell nor buy drugs. Pricing information is supplied for informational purposes only.
Patents
Patent NumberPediatric ExtensionApprovedExpires (estimated)
US9186332No2015-11-172024-04-23Us
US8168218No2012-05-012028-01-07Us
US8309124No2012-11-132024-04-23Us
US8394407No2013-03-122024-04-23Us
US9040085No2015-05-262024-04-23Us
US6488960No2002-12-032020-03-14Us
US6677326No2004-01-132020-03-14Us
US9504699No2016-11-292027-08-03Us
Additional Data Available
  • Filed On
    Filed On

    The date on which a patent was filed with the relevant government.

    Learn more

Properties

State
Solid
Experimental Properties
PropertyValueSource
melting point (°C)230 - 235 °C (decomposes)MSDS
water solubilityVery slightly solubleMSDS
logP1.46MSDS
Predicted Properties
PropertyValueSource
Water Solubility0.111 mg/mLALOGPS
logP2.07ALOGPS
logP1.66ChemAxon
logS-3.5ALOGPS
pKa (Strongest Acidic)12.58ChemAxon
pKa (Strongest Basic)-3.3ChemAxon
Physiological Charge0ChemAxon
Hydrogen Acceptor Count5ChemAxon
Hydrogen Donor Count2ChemAxon
Polar Surface Area91.67 Å2ChemAxon
Rotatable Bond Count2ChemAxon
Refractivity97.57 m3·mol-1ChemAxon
Polarizability38.17 Å3ChemAxon
Number of Rings4ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleNoChemAxon
MDDR-like RuleNoChemAxon
Predicted ADMET features
PropertyValueProbability
Human Intestinal Absorption+0.9918
Blood Brain Barrier+0.9383
Caco-2 permeable-0.5096
P-glycoprotein substrateSubstrate0.7861
P-glycoprotein inhibitor INon-inhibitor0.7847
P-glycoprotein inhibitor IINon-inhibitor0.8383
Renal organic cation transporterNon-inhibitor0.7463
CYP450 2C9 substrateNon-substrate0.8496
CYP450 2D6 substrateNon-substrate0.9138
CYP450 3A4 substrateSubstrate0.7407
CYP450 1A2 substrateNon-inhibitor0.9406
CYP450 2C9 inhibitorNon-inhibitor0.9072
CYP450 2D6 inhibitorNon-inhibitor0.9418
CYP450 2C19 inhibitorNon-inhibitor0.9253
CYP450 3A4 inhibitorNon-inhibitor0.8902
CYP450 inhibitory promiscuityLow CYP Inhibitory Promiscuity0.9095
Ames testNon AMES toxic0.9132
CarcinogenicityNon-carcinogens0.9597
BiodegradationNot ready biodegradable0.925
Rat acute toxicity1.8914 LD50, mol/kg Not applicable
hERG inhibition (predictor I)Weak inhibitor0.95
hERG inhibition (predictor II)Non-inhibitor0.584
ADMET data is predicted using admetSAR, a free tool for evaluating chemical ADMET properties. (23092397)

Spectra

Mass Spec (NIST)
Download (12.5 KB)
Spectra
SpectrumSpectrum TypeSplash Key
Predicted GC-MS Spectrum - GC-MSPredicted GC-MSNot Available
Mass Spectrum (Electron Ionization)MSsplash10-05fs-2951000000-1a9b3a7e18f6088d28db
Predicted MS/MS Spectrum - 10V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 20V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 40V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 10V, Negative (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 20V, Negative (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 40V, Negative (Annotated)Predicted LC-MS/MSNot Available
LC-MS/MS Spectrum - LC-ESI-qTof , PositiveLC-MS/MSNot Available
LC-MS/MS Spectrum - LC-ESI-qTof , PositiveLC-MS/MSNot Available
LC-MS/MS Spectrum - LC-ESI-qTof , PositiveLC-MS/MSNot Available
LC-MS/MS Spectrum - LC-ESI-QFT , negativeLC-MS/MSsplash10-00di-0900000000-1ea12664a8edc235b05c
LC-MS/MS Spectrum - LC-ESI-QFT , negativeLC-MS/MSsplash10-00di-1900000000-06d289c40615662ab14e
LC-MS/MS Spectrum - LC-ESI-QFT , negativeLC-MS/MSsplash10-00di-0900000000-f76738c3bedb48d0c7a3
LC-MS/MS Spectrum - LC-ESI-QTOF , positiveLC-MS/MSsplash10-0a4i-0019000000-d5b5ef89fce8ee6966ba
LC-MS/MS Spectrum - LC-ESI-QTOF , positiveLC-MS/MSsplash10-00r5-0493000000-ae479d92cc77796a5177
LC-MS/MS Spectrum - LC-ESI-QTOF , positiveLC-MS/MSsplash10-00ds-0690000000-f3df1438f8c0623811c1
LC-MS/MS Spectrum - LC-ESI-QTOF , positiveLC-MS/MSsplash10-00dj-0970000000-b61d7f78a4036739cb07
LC-MS/MS Spectrum - LC-ESI-QTOF , positiveLC-MS/MSsplash10-05fs-0940000000-a9c08e5a06f9684fb000
LC-MS/MS Spectrum - LC-ESI-QFT , positiveLC-MS/MSsplash10-0a4l-0149000000-088a79de5c16e3384162
LC-MS/MS Spectrum - LC-ESI-QFT , positiveLC-MS/MSsplash10-006w-2930000000-f901c87bc4fd3221d37e
MS/MS Spectrum - , positiveLC-MS/MSsplash10-05tg-0695000000-35841a4b47ea1535be95
MS/MS Spectrum - , positiveLC-MS/MSsplash10-0a4m-0597000000-c12dc88504062b28c4be
MS/MS Spectrum - , positiveLC-MS/MSsplash10-0002-2960000000-10bdddfba8bd2889acde

Taxonomy

Description
This compound belongs to the class of organic compounds known as 21-hydroxysteroids. These are steroids carrying a hydroxyl group at the 21-position of the steroid backbone.
Kingdom
Organic compounds
Super Class
Lipids and lipid-like molecules
Class
Steroids and steroid derivatives
Sub Class
Hydroxysteroids
Direct Parent
21-hydroxysteroids
Alternative Parents
Gluco/mineralocorticoids, progestogins and derivatives / 20-oxosteroids / 3-oxo delta-1,4-steroids / 17-hydroxysteroids / 11-oxosteroids / Delta-1,4-steroids / Tertiary alcohols / Alpha-hydroxy ketones / Cyclic ketones / Cyclic alcohols and derivatives
show 3 more
Substituents
21-hydroxysteroid / Progestogin-skeleton / Pregnane-skeleton / 20-oxosteroid / 3-oxo-delta-1,4-steroid / 3-oxosteroid / 17-hydroxysteroid / Oxosteroid / 11-oxosteroid / Delta-1,4-steroid
show 13 more
Molecular Framework
Aliphatic homopolycyclic compounds
External Descriptors
17alpha-hydroxy steroid, glucocorticoid, 20-oxo steroid, 3-oxo-Delta(1),Delta(4)-steroid, 11-oxo steroid, 21-hydroxy steroid (CHEBI:8382) / Pregnane and derivatives [Fig] (C07370) / C21 steroids (gluco/mineralocorticoids, progestogins) and derivatives (LMST02030180)

Targets

Kind
Protein
Organism
Humans
Pharmacological action
Yes
Actions
Agonist
General Function
Zinc ion binding
Specific Function
Receptor for glucocorticoids (GC). Has a dual mode of action: as a transcription factor that binds to glucocorticoid response elements (GRE), both for nuclear and mitochondrial DNA, and as a modula...
Gene Name
NR3C1
Uniprot ID
P04150
Uniprot Name
Glucocorticoid receptor
Molecular Weight
85658.57 Da
References
  1. Liu BG, Li ZY, Du M: [Effects of jingui shenqi pill combined prednisone on expression of glucocorticoid receptor and its clinical effect in treating bullous pemphigoid patients]. Zhongguo Zhong Xi Yi Jie He Za Zhi. 2006 Oct;26(10):881-4. [PubMed:17121036]
  2. Friel PN, Alexander T, Wright JV: Suppression of adrenal function by low-dose prednisone: assessment with 24-hour urinary steroid hormone profiles--a review of five cases. Altern Med Rev. 2006 Mar;11(1):40-6. [PubMed:16597193]
  3. Diez JJ, Iglesias P: Pharmacological therapy of Cushing's syndrome: drugs and indications. Mini Rev Med Chem. 2007 May;7(5):467-80. [PubMed:17504182]
  4. Yano A, Fujii Y, Iwai A, Kawakami S, Kageyama Y, Kihara K: Glucocorticoids suppress tumor lymphangiogenesis of prostate cancer cells. Clin Cancer Res. 2006 Oct 15;12(20 Pt 1):6012-7. [PubMed:17062674]
  5. Yano A, Fujii Y, Iwai A, Kageyama Y, Kihara K: Glucocorticoids suppress tumor angiogenesis and in vivo growth of prostate cancer cells. Clin Cancer Res. 2006 May 15;12(10):3003-9. [PubMed:16707595]
  6. Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. [PubMed:11752352]
  7. Czock D, Keller F, Rasche FM, Haussler U: Pharmacokinetics and pharmacodynamics of systemically administered glucocorticoids. Clin Pharmacokinet. 2005;44(1):61-98. doi: 10.2165/00003088-200544010-00003. [PubMed:15634032]

Enzymes

Kind
Protein
Organism
Humans
Pharmacological action
Unknown
Actions
Substrate
Inducer
General Function
Vitamin d3 25-hydroxylase activity
Specific Function
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It performs a variety of oxidation react...
Gene Name
CYP3A4
Uniprot ID
P08684
Uniprot Name
Cytochrome P450 3A4
Molecular Weight
57342.67 Da
References
  1. Hardy KW, Crocker JF, McLellan H, Goralski KB, Renton KW, Acott PD: Paradoxical cyclosporine A requirements in pediatric renal transplants receiving high-dose steroids. J Clin Pharmacol. 2005 Feb;45(2):161-7. doi: 10.1177/0091270004271403. [PubMed:15647408]
  2. Pichard L, Fabre I, Daujat M, Domergue J, Joyeux H, Maurel P: Effect of corticosteroids on the expression of cytochromes P450 and on cyclosporin A oxidase activity in primary cultures of human hepatocytes. Mol Pharmacol. 1992 Jun;41(6):1047-55. [PubMed:1614409]
  3. Miura M, Inoue K, Kagaya H, Saito M, Habuchi T, Satoh S: Inter-individual difference determinant of prednisolone pharmacokinetics for Japanese renal transplant recipients in the maintenance stage. Xenobiotica. 2009 Dec;39(12):939-45. doi: 10.3109/00498250903294361. [PubMed:19795924]
  4. Usui T, Saitoh Y, Komada F: Induction of CYP3As in HepG2 cells by several drugs. Association between induction of CYP3A4 and expression of glucocorticoid receptor. Biol Pharm Bull. 2003 Apr;26(4):510-7. doi: 10.1248/bpb.26.510. [PubMed:12673034]
  5. Matoulkova P, Pavek P, Maly J, Vlcek J: Cytochrome P450 enzyme regulation by glucocorticoids and consequences in terms of drug interaction. Expert Opin Drug Metab Toxicol. 2014 Mar;10(3):425-35. doi: 10.1517/17425255.2014.878703. Epub 2014 Jan 23. [PubMed:24451000]
Kind
Protein
Organism
Humans
Pharmacological action
Unknown
Actions
Inducer
General Function
Steroid hydroxylase activity
Specific Function
Responsible for the metabolism of a number of therapeutic agents such as the anticonvulsant drug S-mephenytoin, omeprazole, proguanil, certain barbiturates, diazepam, propranolol, citalopram and im...
Gene Name
CYP2C19
Uniprot ID
P33261
Uniprot Name
Cytochrome P450 2C19
Molecular Weight
55930.545 Da
References
  1. Helsby NA, Hui CY, Goldthorpe MA, Coller JK, Soh MC, Gow PJ, De Zoysa JZ, Tingle MD: The combined impact of CYP2C19 and CYP2B6 pharmacogenetics on cyclophosphamide bioactivation. Br J Clin Pharmacol. 2010 Dec;70(6):844-53. doi: 10.1111/j.1365-2125.2010.03789.x. [PubMed:21175440]
  2. Matoulkova P, Pavek P, Maly J, Vlcek J: Cytochrome P450 enzyme regulation by glucocorticoids and consequences in terms of drug interaction. Expert Opin Drug Metab Toxicol. 2014 Mar;10(3):425-35. doi: 10.1517/17425255.2014.878703. Epub 2014 Jan 23. [PubMed:24451000]
  3. Cytochrome P450 drug interactions [File]
  4. Mayo medical laboratory document [File]
Kind
Protein
Organism
Humans
Pharmacological action
Unknown
Actions
Inducer
General Function
Oxygen binding
Specific Function
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally un...
Gene Name
CYP3A5
Uniprot ID
P20815
Uniprot Name
Cytochrome P450 3A5
Molecular Weight
57108.065 Da
References
  1. Dvorak Z, Pavek P: Regulation of drug-metabolizing cytochrome P450 enzymes by glucocorticoids. Drug Metab Rev. 2010 Nov;42(4):621-35. doi: 10.3109/03602532.2010.484462. [PubMed:20482443]
Kind
Protein group
Organism
Humans
Pharmacological action
Unknown
Actions
Inducer
General Function
Vitamin d3 25-hydroxylase activity
Specific Function
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It performs a variety of oxidation react...

Components:
References
  1. Matoulkova P, Pavek P, Maly J, Vlcek J: Cytochrome P450 enzyme regulation by glucocorticoids and consequences in terms of drug interaction. Expert Opin Drug Metab Toxicol. 2014 Mar;10(3):425-35. doi: 10.1517/17425255.2014.878703. Epub 2014 Jan 23. [PubMed:24451000]
Kind
Protein
Organism
Humans
Pharmacological action
Unknown
Actions
Inducer
General Function
Steroid hydroxylase activity
Specific Function
Exhibits a high coumarin 7-hydroxylase activity. Can act in the hydroxylation of the anti-cancer drugs cyclophosphamide and ifosphamide. Competent in the metabolic activation of aflatoxin B1. Const...
Gene Name
CYP2A6
Uniprot ID
P11509
Uniprot Name
Cytochrome P450 2A6
Molecular Weight
56501.005 Da
References
  1. Matoulkova P, Pavek P, Maly J, Vlcek J: Cytochrome P450 enzyme regulation by glucocorticoids and consequences in terms of drug interaction. Expert Opin Drug Metab Toxicol. 2014 Mar;10(3):425-35. doi: 10.1517/17425255.2014.878703. Epub 2014 Jan 23. [PubMed:24451000]
Kind
Protein
Organism
Humans
Pharmacological action
Unknown
Actions
Inducer
General Function
Oxygen binding
Specific Function
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally un...
Gene Name
CYP1B1
Uniprot ID
Q16678
Uniprot Name
Cytochrome P450 1B1
Molecular Weight
60845.33 Da
References
  1. Matoulkova P, Pavek P, Maly J, Vlcek J: Cytochrome P450 enzyme regulation by glucocorticoids and consequences in terms of drug interaction. Expert Opin Drug Metab Toxicol. 2014 Mar;10(3):425-35. doi: 10.1517/17425255.2014.878703. Epub 2014 Jan 23. [PubMed:24451000]
Kind
Protein
Organism
Humans
Pharmacological action
Unknown
Actions
Inducer
General Function
Steroid hydroxylase activity
Specific Function
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally un...
Gene Name
CYP2B6
Uniprot ID
P20813
Uniprot Name
Cytochrome P450 2B6
Molecular Weight
56277.81 Da
References
  1. Matoulkova P, Pavek P, Maly J, Vlcek J: Cytochrome P450 enzyme regulation by glucocorticoids and consequences in terms of drug interaction. Expert Opin Drug Metab Toxicol. 2014 Mar;10(3):425-35. doi: 10.1517/17425255.2014.878703. Epub 2014 Jan 23. [PubMed:24451000]
Kind
Protein
Organism
Humans
Pharmacological action
Unknown
Actions
Inducer
General Function
Steroid hydroxylase activity
Specific Function
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally un...
Gene Name
CYP2C8
Uniprot ID
P10632
Uniprot Name
Cytochrome P450 2C8
Molecular Weight
55824.275 Da
References
  1. Matoulkova P, Pavek P, Maly J, Vlcek J: Cytochrome P450 enzyme regulation by glucocorticoids and consequences in terms of drug interaction. Expert Opin Drug Metab Toxicol. 2014 Mar;10(3):425-35. doi: 10.1517/17425255.2014.878703. Epub 2014 Jan 23. [PubMed:24451000]
Kind
Protein
Organism
Humans
Pharmacological action
Unknown
Actions
Inducer
General Function
Steroid hydroxylase activity
Specific Function
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally un...
Gene Name
CYP2C9
Uniprot ID
P11712
Uniprot Name
Cytochrome P450 2C9
Molecular Weight
55627.365 Da
References
  1. Matoulkova P, Pavek P, Maly J, Vlcek J: Cytochrome P450 enzyme regulation by glucocorticoids and consequences in terms of drug interaction. Expert Opin Drug Metab Toxicol. 2014 Mar;10(3):425-35. doi: 10.1517/17425255.2014.878703. Epub 2014 Jan 23. [PubMed:24451000]
Kind
Protein
Organism
Humans
Pharmacological action
Unknown
Actions
Substrate
General Function
11-beta-hydroxysteroid dehydrogenase [nad(p)] activity
Specific Function
Catalyzes reversibly the conversion of cortisol to the inactive metabolite cortisone. Catalyzes reversibly the conversion of 7-ketocholesterol to 7-beta-hydroxycholesterol. In intact cells, the rea...
Gene Name
HSD11B1
Uniprot ID
P28845
Uniprot Name
Corticosteroid 11-beta-dehydrogenase isozyme 1
Molecular Weight
32400.665 Da
References
  1. Raza K, Hardy R, Cooper MS: The 11beta-hydroxysteroid dehydrogenase enzymes--arbiters of the effects of glucocorticoids in synovium and bone. Rheumatology (Oxford). 2010 Nov;49(11):2016-23. doi: 10.1093/rheumatology/keq212. Epub 2010 Jul 15. [PubMed:20634231]

Carriers

Kind
Protein
Organism
Humans
Pharmacological action
Unknown
Actions
Substrate
General Function
Toxic substance binding
Specific Function
Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloid...
Gene Name
ALB
Uniprot ID
P02768
Uniprot Name
Serum albumin
Molecular Weight
69365.94 Da
References
  1. Ferry JJ, Wagner JG: The nonlinear pharmacokinetics of prednisone and prednisolone. II. Plasma protein binding of prednisone and prednisolone in rabbit and human plasma. Biopharm Drug Dispos. 1987 May-Jun;8(3):261-72. [PubMed:3593903]
  2. Czock D, Keller F, Rasche FM, Haussler U: Pharmacokinetics and pharmacodynamics of systemically administered glucocorticoids. Clin Pharmacokinet. 2005;44(1):61-98. doi: 10.2165/00003088-200544010-00003. [PubMed:15634032]
Kind
Protein
Organism
Humans
Pharmacological action
Unknown
Actions
Binder
General Function
Steroid binding
Specific Function
Major transport protein for glucocorticoids and progestins in the blood of almost all vertebrate species.
Gene Name
SERPINA6
Uniprot ID
P08185
Uniprot Name
Corticosteroid-binding globulin
Molecular Weight
45140.49 Da
References
  1. Gardill BR, Vogl MR, Lin HY, Hammond GL, Muller YA: Corticosteroid-binding globulin: structure-function implications from species differences. PLoS One. 2012;7(12):e52759. doi: 10.1371/journal.pone.0052759. Epub 2012 Dec 26. [PubMed:23300763]

Transporters

Kind
Protein
Organism
Humans
Pharmacological action
Unknown
Actions
Substrate
Inducer
General Function
Xenobiotic-transporting atpase activity
Specific Function
Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells.
Gene Name
ABCB1
Uniprot ID
P08183
Uniprot Name
Multidrug resistance protein 1
Molecular Weight
141477.255 Da
References
  1. Nagy H, Goda K, Fenyvesi F, Bacso Z, Szilasi M, Kappelmayer J, Lustyik G, Cianfriglia M, Szabo G Jr: Distinct groups of multidrug resistance modulating agents are distinguished by competition of P-glycoprotein-specific antibodies. Biochem Biophys Res Commun. 2004 Mar 19;315(4):942-9. [PubMed:14985103]
  2. Yates CR, Chang C, Kearbey JD, Yasuda K, Schuetz EG, Miller DD, Dalton JT, Swaan PW: Structural determinants of P-glycoprotein-mediated transport of glucocorticoids. Pharm Res. 2003 Nov;20(11):1794-803. [PubMed:14661924]
  3. Dilger K, Schwab M, Fromm MF: Identification of budesonide and prednisone as substrates of the intestinal drug efflux pump P-glycoprotein. Inflamm Bowel Dis. 2004 Sep;10(5):578-83. [PubMed:15472518]
  4. Matoulkova P, Pavek P, Maly J, Vlcek J: Cytochrome P450 enzyme regulation by glucocorticoids and consequences in terms of drug interaction. Expert Opin Drug Metab Toxicol. 2014 Mar;10(3):425-35. doi: 10.1517/17425255.2014.878703. Epub 2014 Jan 23. [PubMed:24451000]
Kind
Protein
Organism
Humans
Pharmacological action
Unknown
Actions
Inhibitor
General Function
Sodium-independent organic anion transmembrane transporter activity
Specific Function
Mediates the Na(+)-independent transport of organic anions such as sulfobromophthalein (BSP) and conjugated (taurocholate) and unconjugated (cholate) bile acids (By similarity). Selectively inhibit...
Gene Name
SLCO1A2
Uniprot ID
P46721
Uniprot Name
Solute carrier organic anion transporter family member 1A2
Molecular Weight
74144.105 Da
References
  1. Bossuyt X, Muller M, Hagenbuch B, Meier PJ: Polyspecific drug and steroid clearance by an organic anion transporter of mammalian liver. J Pharmacol Exp Ther. 1996 Mar;276(3):891-6. [PubMed:8786566]

Drug created on June 13, 2005 07:24 / Updated on December 11, 2019 03:30