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Displaying drugs 251 - 275 of 5107 in total
Omidenepag isopropyl
Omidenepag isopropyl is a topical ocular hypotensive agent used to reduce intraocular pressure (IOP) in patients with glaucoma and ocular hypertension. Omidenepag isopropyl is quickly metabolized to its active metabolite, omidenepag, a molecule with high selectivity and agonistic activity towards the prostaglandin E2 (EP2) receptor.[A253263,A253268] Prostanoid FP receptor agonists (FP...
Approved
Investigational
Matched Synonyms: … isopropyl N-(6-(((4-(1H-pyrazol-1-yl)benzyl)(3-pyridinylsulfonyl)amino)methyl)-2-pyridinyl)glycinate …
Matched Iupac: … propan-2-yl 2-({6-[(N-{[4-(1H-pyrazol-1-yl)phenyl]methyl}pyridine-3-sulfonamido)methyl]pyridin-2-yl}amino …
Matched Description: … [A253253] In 2018, omidenepag isopropyl was approved in Japan for the treatment of glaucoma and ocular ... [A253268] In September 2022, the FDA approved the use of omidenepag isopropyl.[L43503] ... Omidenepag isopropyl is a topical ocular hypotensive agent used to reduce intraocular pressure (IOP) …
Matched Iupac: … propan-2-yl 2-({6-[(N-{[4-(1H-pyrazol-1-yl)phenyl]methyl}pyridine-3-sulfonamido)methyl]pyridin-2-yl}amino …
Matched Description: … [A253253] In 2018, omidenepag isopropyl was approved in Japan for the treatment of glaucoma and ocular ... [A253268] In September 2022, the FDA approved the use of omidenepag isopropyl.[L43503] ... Omidenepag isopropyl is a topical ocular hypotensive agent used to reduce intraocular pressure (IOP) …
Calcium glycerophosphate
Calcium glycerophosphate is a DB01373 salt of glycerophosphoric acid that forms a white, fine, slightly hygroscopic powder. The commercial product is a mixture of calcium beta-, and D-, and L -alpha-glycerophosphate. By FDA, calcium glycerophosphate is considered a generally recognized as safe (GRAS) food ingredient as a nutrient supplement (source...
Approved
Matched Iupac: … calcium 2-(phosphonooxy)propane-1,3-diol …
Matched Description: … The commercial product is a mixture of calcium beta-, and D-, and L -alpha-glycerophosphate. ... , and fillings. ... Calcium glycerophosphate is a [DB01373] salt of glycerophosphoric acid that forms a white, fine, slightly …
Matched Mixtures name: … Alsimine W Vitamins A D ... Somarexin and C 1000 ... NUTROPLEX LIQUID WITH IRON AND LYSINE …
Matched Description: … The commercial product is a mixture of calcium beta-, and D-, and L -alpha-glycerophosphate. ... , and fillings. ... Calcium glycerophosphate is a [DB01373] salt of glycerophosphoric acid that forms a white, fine, slightly …
Matched Mixtures name: … Alsimine W Vitamins A D ... Somarexin and C 1000 ... NUTROPLEX LIQUID WITH IRON AND LYSINE …
Betibeglogene autotemcel
Betibeglogene autotemcel is an autologous gene therapy that adds functional copies of the β-globin gene (βA-T87Q-globin) to hematopoietic stem cells in order to treat β-thalassemia. β-thalassemia is a condition caused by mutations in the β-globin gene (HBB) that leads to a significant decrease in the production of β-globin. This affects...
Approved
Investigational
Matched Description: … [A251770,A251785] Betibeglogene autotemcel was approved by the FDA in August 2022 and is the first ex-vivo ... [L42940] β-thalassemia is a condition caused by mutations in the β-globin gene (HBB) that leads to a ... transfusions are required for survival and the prevention of serious complications. …
Matched Categories: … Blood and Blood Forming Organs …
Matched Categories: … Blood and Blood Forming Organs …
Perampanel
Perampanel is a noncompetitive AMPA glutamate receptor antagonist. It is marketed under the name Fycompa™ and is indicated as an adjunct in patients over 12 years old for the treatment of partial-onset seizures that may or may not occur with generalized seizures. The FDA label includes an important black-boxed warning...
Approved
Matched Synonyms: … 3-(2-Cyanophenyl)-5-(2-pyridyl)-1-phenyl-1,2-dihydropyridin-2-one …
Matched Iupac: … 2-{6'-oxo-1'-phenyl-1',6'-dihydro-[2,3'-bipyridine]-5'-yl}benzonitrile …
Matched Description: … Perampanel is a noncompetitive AMPA glutamate receptor antagonist. ... It is marketed under the name Fycompa™ and is indicated as an adjunct in patients over 12 years old for ... The FDA label includes an important black-boxed warning of serious or life-threatening behavioral and …
Matched Products: … FYCOMPA (2 MG) ... FYCOMPA® 2 MG ... Fypalan 2 mg-Filmtabletten …
Matched Iupac: … 2-{6'-oxo-1'-phenyl-1',6'-dihydro-[2,3'-bipyridine]-5'-yl}benzonitrile …
Matched Description: … Perampanel is a noncompetitive AMPA glutamate receptor antagonist. ... It is marketed under the name Fycompa™ and is indicated as an adjunct in patients over 12 years old for ... The FDA label includes an important black-boxed warning of serious or life-threatening behavioral and …
Matched Products: … FYCOMPA (2 MG) ... FYCOMPA® 2 MG ... Fypalan 2 mg-Filmtabletten …
Caspofungin
Caspofungin (brand name Cancidas worldwide) is an antifungal drug and the first member of a new drug class called the echinocandins, as coined by Merck & Co., Inc. It is typically administered intravenously. It shows activity against infections with Aspergillus and Candida, and works by inhibiting β(1,3)-D-Glucan of the fungal...
Approved
Matched Synonyms: … (4R,5S)-5-((2-Aminoethyl)amino)-N(sup 2)-(10,12-dimethyltetradecanoyl)-4-hydroxy-L-ornithyl-L-threonyl-trans ... -4-hydroxy-L-prolyl-(S)-4-hydroxy-4-(p-hydroxyphenyl)-L-threonyl-threo-3-hydroxy-L-ornithyl-trans-3-hydroxy-L-proline …
Matched Iupac: … (10R,12S)-N-[(3S,6S,9S,11R,15S,18S,20R,21S,24S,25S)-3-[(1R)-3-amino-1-hydroxypropyl]-21-[(2-aminoethyl ... )amino]-6-[(1S,2S)-1,2-dihydroxy-2-(4-hydroxyphenyl)ethyl]-11,20,25-trihydroxy-15-[(1R)-1-hydroxyethyl …
Matched Description: … Caspofungin (brand name Cancidas worldwide) is an antifungal drug and the first member of a new drug ... It shows activity against infections with Aspergillus and Candida, and works by inhibiting β(1,3)-D-Glucan …
Matched Salts cas: … 179463-17-3 …
Matched Categories: … Amino Acids, Peptides, and Proteins …
Matched Products: … CASPOFUNGINA 50 MG/VIAL POLVO PARA RECONSTITUIR A SOLUCION INYECTABLE ... CASPOVITAE® 50 MG POLVO LIOFILIZADO PARA RECONSTITUIR A SOLUCION INYECTABLE ... CASPOVITAE ® 70 MG POLVO LIOFILIZADO PARA RECONSTITUIR A SOLUCION INYECTABLE …
Matched Iupac: … (10R,12S)-N-[(3S,6S,9S,11R,15S,18S,20R,21S,24S,25S)-3-[(1R)-3-amino-1-hydroxypropyl]-21-[(2-aminoethyl ... )amino]-6-[(1S,2S)-1,2-dihydroxy-2-(4-hydroxyphenyl)ethyl]-11,20,25-trihydroxy-15-[(1R)-1-hydroxyethyl …
Matched Description: … Caspofungin (brand name Cancidas worldwide) is an antifungal drug and the first member of a new drug ... It shows activity against infections with Aspergillus and Candida, and works by inhibiting β(1,3)-D-Glucan …
Matched Salts cas: … 179463-17-3 …
Matched Categories: … Amino Acids, Peptides, and Proteins …
Matched Products: … CASPOFUNGINA 50 MG/VIAL POLVO PARA RECONSTITUIR A SOLUCION INYECTABLE ... CASPOVITAE® 50 MG POLVO LIOFILIZADO PARA RECONSTITUIR A SOLUCION INYECTABLE ... CASPOVITAE ® 70 MG POLVO LIOFILIZADO PARA RECONSTITUIR A SOLUCION INYECTABLE …
Sodium phosphate P 32
Approved
Lofexidine
Lofexidine is a non-opioid centrally acting alpha2-adrenergic receptor agonist that was first approved for the treatment of opioid withdrawal in the United Kingdom in 1992. It was first studied for use as an antihypertensive in 1980, but its researched was stopped as it was found less effective for the treatment...
Approved
Investigational
Matched Synonyms: … 2-(alpha-(2,6-Dichlorophenoxy)ethyl)2-imidazoline …
Matched Iupac: … 2-[1-(2,6-dichlorophenoxy)ethyl]-4,5-dihydro-1H-imidazole …
Matched Description: … Lofexidine is a non-opioid centrally acting alpha2-adrenergic receptor agonist that was first approved ... [T209] Lofexidine was developed by US Woldmeds LLC and it was approved by the FDA on May 16, 2018. ... Lofexidine was then repurposed for the treatment of opioid withdrawal, as it was seen to be more economical and …
Matched Categories: … Adrenergic alpha-2 Receptor Agonists ... Central alpha-2 Adrenergic Agonist …
Matched Iupac: … 2-[1-(2,6-dichlorophenoxy)ethyl]-4,5-dihydro-1H-imidazole …
Matched Description: … Lofexidine is a non-opioid centrally acting alpha2-adrenergic receptor agonist that was first approved ... [T209] Lofexidine was developed by US Woldmeds LLC and it was approved by the FDA on May 16, 2018. ... Lofexidine was then repurposed for the treatment of opioid withdrawal, as it was seen to be more economical and …
Matched Categories: … Adrenergic alpha-2 Receptor Agonists ... Central alpha-2 Adrenergic Agonist …
Cefapirin
Cefapirin (INN, also spelled cephapirin), commonly marketed under the trade name Cefadyl, is a first-generation cephalosporin antibiotic that is available in injectable formulations. Production for use in humans has been discontinued in the United States. Cefapirin is partly plasma-bound and is effective against gram-negative and gram-positive organisms.
Approved
Vet approved
Matched Synonyms: … -2-ene-2-carboxylic acid ... (6R,7R)-3-(acetoxymethyl)-8-oxo-7-{[(pyridin-4-ylsulfanyl)acetyl]amino}-5-thia-1-azabicyclo[4.2.0]oct …
Matched Iupac: … (6R,7R)-3-[(acetyloxy)methyl]-8-oxo-7-[2-(pyridin-4-ylsulfanyl)acetamido]-5-thia-1-azabicyclo[4.2.0]oct ... -2-ene-2-carboxylic acid …
Matched Description: … Cefapirin is partly plasma-bound and is effective against gram-negative and gram-positive organisms. ... Cefapirin (INN, also spelled cephapirin), commonly marketed under the trade name Cefadyl, is a first-generation …
Matched Salts cas: … 24356-60-3 …
Matched Categories: … Heterocyclic Compounds, 2-Ring …
Matched Iupac: … (6R,7R)-3-[(acetyloxy)methyl]-8-oxo-7-[2-(pyridin-4-ylsulfanyl)acetamido]-5-thia-1-azabicyclo[4.2.0]oct ... -2-ene-2-carboxylic acid …
Matched Description: … Cefapirin is partly plasma-bound and is effective against gram-negative and gram-positive organisms. ... Cefapirin (INN, also spelled cephapirin), commonly marketed under the trade name Cefadyl, is a first-generation …
Matched Salts cas: … 24356-60-3 …
Matched Categories: … Heterocyclic Compounds, 2-Ring …
Mometasone furoate
Mometasone furoate is a corticosteroid drug that can be used for the treatment of asthma, rhinitis, and certain skin conditions[FDA Label][F4292,F4295]. It has a glucocorticoid receptor binding affinity 22 times stronger than dexamethasone and higher than many other corticosteroids as well . Mometasone furoate is formulated as a dry powder...
Approved
Investigational
Vet approved
Matched Iupac: … 2H,3H,3aH,3bH,4H,5H,7H,9aH,9bH,10H,11H,11aH-cyclopenta[a]phenanthren-1-yl furan-2-carboxylate ... (1R,2R,3aS,3bS,9aS,9bR,10S,11aS)-9b-chloro-1-(2-chloroacetyl)-10-hydroxy-2,9a,11a-trimethyl-7-oxo-1H, …
Matched Description: … Mometasone furoate is a corticosteroid drug that can be used for the treatment of asthma, rhinitis, and ... Mometasone furoate is formulated as a dry powder inhaler, nasal spray, and ointment for its different ... It has a glucocorticoid receptor binding affinity 22 times stronger than [dexamethasone] and higher than …
Matched Mixtures name: … M-FURO FA %0.1 + %2 KREM, 30 G ... MATEC 2/200 MCG INHALASYON TOZ IÇEREN KAPSÜL , 60 KAPSÜL ... MATEC 2/200 MCG INHALASYON TOZ IÇEREN KAPSÜL , 120 KAPSÜL …
Matched Categories: … formoterol and mometasone …
Matched Products: … Up and Up Allergy ... Nasonex Allergy and Congestion ... Nasal Allergy and Congestion Relief …
Matched Description: … Mometasone furoate is a corticosteroid drug that can be used for the treatment of asthma, rhinitis, and ... Mometasone furoate is formulated as a dry powder inhaler, nasal spray, and ointment for its different ... It has a glucocorticoid receptor binding affinity 22 times stronger than [dexamethasone] and higher than …
Matched Mixtures name: … M-FURO FA %0.1 + %2 KREM, 30 G ... MATEC 2/200 MCG INHALASYON TOZ IÇEREN KAPSÜL , 60 KAPSÜL ... MATEC 2/200 MCG INHALASYON TOZ IÇEREN KAPSÜL , 120 KAPSÜL …
Matched Categories: … formoterol and mometasone …
Matched Products: … Up and Up Allergy ... Nasonex Allergy and Congestion ... Nasal Allergy and Congestion Relief …
VidPrevtyn Beta
VidPrevtyn Beta is an adjuvanted, recombinant COVID-19 vaccine developed collaboratively by GlaxoSmithKline (GSK) and Sanofi Pasteur. It comprises a recombinant SARS-CoV-2 spike protein (B.1.351 strain) - produced by recombinant DNA technology using a baculovirus expression system in an insect cell line that is
derived from Sf9 cells of the fall...
Approved
Investigational
Matched Synonyms: … SARS-CoV-2 prefusion Spike delta TM protein, recombinant (B.1.351 strain) …
Matched Description: … [L49691] It comprises a recombinant SARS-CoV-2 spike protein (B.1.351 strain) - produced by recombinant ... [A245829,L49696] In October 2022, VidPrevtyn Beta was approved in the European Union for use as a ... Beta is an adjuvanted, recombinant COVID-19 vaccine developed collaboratively by GlaxoSmithKline (GSK) and …
Matched Description: … [L49691] It comprises a recombinant SARS-CoV-2 spike protein (B.1.351 strain) - produced by recombinant ... [A245829,L49696] In October 2022, VidPrevtyn Beta was approved in the European Union for use as a ... Beta is an adjuvanted, recombinant COVID-19 vaccine developed collaboratively by GlaxoSmithKline (GSK) and …
Fenbufen
Fenbufen is a non-steroidal anti-inflammatory drug used primarily to treat inflammation in osteoarthritis, ankylosing spondylitis, and tendinitis. It can also be used to relieve backaches, sprains, and fractures. Fenbufen is available as a capsule or tablet sold with the brand names Cepal, Cinopal, Cybufen, Lederfen, and Reugast. Fenbufen acts by...
Approved
Matched Synonyms: … 3-(4-Phenylbenzoyl)propionic acid ... 3-(4-Biphenylylcarbonyl)propionic acid …
Matched Description: … Fenbufen is available as a capsule or tablet sold with the brand names Cepal, Cinopal, Cybufen, Lederfen ... , and Reugast. ... , ankylosing spondylitis, and tendinitis. …
Matched Categories: … Non COX-2 selective NSAIDS ... Antiinflammatory and Antirheumatic Products ... Antiinflammatory and Antirheumatic Products, Non-Steroids …
Matched Description: … Fenbufen is available as a capsule or tablet sold with the brand names Cepal, Cinopal, Cybufen, Lederfen ... , and Reugast. ... , ankylosing spondylitis, and tendinitis. …
Matched Categories: … Non COX-2 selective NSAIDS ... Antiinflammatory and Antirheumatic Products ... Antiinflammatory and Antirheumatic Products, Non-Steroids …
Polyethylene glycol 300
Polyethylene glycol 300 (PEG 300) is a water-miscible polyether with an average molecular weight of 300 g/mol. It is a clear viscous liquid at room temperature with non-volatile, stable properties . Polyethylene glycols are widely used in biochemistry, structural biology, and medicine in addition to pharmaceutical and chemical industries. They...
Approved
Matched Description: … PEG 300 is found in eye drops as a lubricant to temporarily relieve redness, burning and irritation of ... pharmaceutical and chemical industries. ... It is a clear viscous liquid at room temperature with non-volatile, stable properties [A33116]. …
Matched Mixtures name: … Lubricant and Redness Reliever …
Matched Categories: … Compounds used in a research, industrial, or household setting …
Matched Mixtures name: … Lubricant and Redness Reliever …
Matched Categories: … Compounds used in a research, industrial, or household setting …
Beclomethasone dipropionate
Beclomethasone dipropionate is a second-generation synthetic corticosteroid and diester of beclomethasone, which is structurally similar to dexamethasone. It is a prodrug of an active metabolite beclomethasone 17-monopropionate (17-BMP) which acts on the glucocorticoid receptor to mediates its therapeutic action. Beclomethasone dipropionate itself posesses weak glucocorticoid receptor binding affinity and is...
Approved
Investigational
Matched International brands: … Clenil-A …
Matched Iupac: … ,2H,3H,3aH,3bH,4H,5H,7H,9aH,9bH,10H,11H,11aH-cyclopenta[a]phenanthren-1-yl]-2-oxoethyl propanoate ... 2-[(1R,2S,3aS,3bS,9aS,9bR,10S,11aS)-9b-chloro-10-hydroxy-2,9a,11a-trimethyl-7-oxo-1-(propanoyloxy)-1H …
Matched Description: … later in a dry powder inhaler and an aqueous nasal spray. ... Beclomethasone dipropionate is a second-generation[A179842] synthetic corticosteroid and diester of beclomethasone ... Beclomethasone dipropionate became first available in a pressurized metered-dose inhaler in 1972 and …
Matched Salts cas: … 77011-63-3 …
Matched Mixtures name: … Ibicar S (Salbutamol 100 mcg/actuation and Beclometasone 50 mcg/actuation) Pressurised Inhalation …
Matched Categories: … Alimentary Tract and Metabolism ... formoterol and beclometasone ... salbutamol and beclometasone ... beclometasone and antibiotics ... formoterol, glycopyrronium bromide and beclometasone …
Matched Iupac: … ,2H,3H,3aH,3bH,4H,5H,7H,9aH,9bH,10H,11H,11aH-cyclopenta[a]phenanthren-1-yl]-2-oxoethyl propanoate ... 2-[(1R,2S,3aS,3bS,9aS,9bR,10S,11aS)-9b-chloro-10-hydroxy-2,9a,11a-trimethyl-7-oxo-1-(propanoyloxy)-1H …
Matched Description: … later in a dry powder inhaler and an aqueous nasal spray. ... Beclomethasone dipropionate is a second-generation[A179842] synthetic corticosteroid and diester of beclomethasone ... Beclomethasone dipropionate became first available in a pressurized metered-dose inhaler in 1972 and …
Matched Salts cas: … 77011-63-3 …
Matched Mixtures name: … Ibicar S (Salbutamol 100 mcg/actuation and Beclometasone 50 mcg/actuation) Pressurised Inhalation …
Matched Categories: … Alimentary Tract and Metabolism ... formoterol and beclometasone ... salbutamol and beclometasone ... beclometasone and antibiotics ... formoterol, glycopyrronium bromide and beclometasone …
Trimethoprim
Trimethoprim is an antifolate antibacterial agent that inhibits bacterial dihydrofolate reductase (DHFR), a critical enzyme that catalyzes the formation of tetrahydrofolic acid (THF) - in doing so, it prevents the synthesis of bacterial DNA and ultimately continued bacterial survival. Trimethoprim is often used in combination with sulfamethoxazole due to their...
Approved
Vet approved
Matched Description: … synergistic mechanisms but may be used as a monotherapy in the treatment and/or prophylaxis of urinary ... Trimethoprim is an antifolate antibacterial agent that inhibits bacterial dihydrofolate reductase (DHFR), a ... the formation of tetrahydrofolic acid (THF) - in doing so, it prevents the synthesis of bacterial DNA and …
Matched Salts cas: … 60834-30-2 ... 56585-33-2 …
Matched Mixtures name: … Sulfamethoxazole and Trimethoprim ... Sulfamethoxazole and Trimethoprim ... Sulfamethoxazole and Trimethoprim …
Matched Categories: … MATE 2 Inhibitors ... MATE 2 Substrates ... Trimethoprim and Derivatives ... sulfamoxole and trimethoprim ... Sulfonamides and trimethoprim …
Matched Salts cas: … 60834-30-2 ... 56585-33-2 …
Matched Mixtures name: … Sulfamethoxazole and Trimethoprim ... Sulfamethoxazole and Trimethoprim ... Sulfamethoxazole and Trimethoprim …
Matched Categories: … MATE 2 Inhibitors ... MATE 2 Substrates ... Trimethoprim and Derivatives ... sulfamoxole and trimethoprim ... Sulfonamides and trimethoprim …
Ximelagatran
Ximelagatran is an anticoagulant intended to become a replacement for warfarin by overcoming the dietary restrictions, drug interaction, and monitoring issues associated with the former. In 2006, its manufacturer AstraZeneca announced that it would not attempt to market ximelagatran after reports of hepatotoxicity (liver damage) during trials, and to discontinue...
Approved
Investigational
Withdrawn
Matched Synonyms: … ethyl 2-[[(1R)-1-cyclohexyl-2- [(2S)-2-[[4-(N'-hydroxycarbamimidoyl) phenyl]methylcarbamoyl]azetidin- ... 1-yl]- 2-oxo-ethyl]amino]acetate …
Matched Iupac: … ethyl 2-{[(1R)-1-cyclohexyl-2-[(2S)-2-[({4-[(Z)-N'-hydroxycarbamimidoyl]phenyl}methyl)carbamoyl]azetidin ... -1-yl]-2-oxoethyl]amino}acetate …
Matched Description: … to discontinue its distribution in countries where the drug had been approved. ... Ximelagatran is an anticoagulant intended to become a replacement for warfarin by overcoming the dietary ... restrictions, drug interaction, and monitoring issues associated with the former. …
Matched Categories: … Blood and Blood Forming Organs …
Matched Iupac: … ethyl 2-{[(1R)-1-cyclohexyl-2-[(2S)-2-[({4-[(Z)-N'-hydroxycarbamimidoyl]phenyl}methyl)carbamoyl]azetidin ... -1-yl]-2-oxoethyl]amino}acetate …
Matched Description: … to discontinue its distribution in countries where the drug had been approved. ... Ximelagatran is an anticoagulant intended to become a replacement for warfarin by overcoming the dietary ... restrictions, drug interaction, and monitoring issues associated with the former. …
Matched Categories: … Blood and Blood Forming Organs …
Sparfloxacin
Sparfloxacin is a fluoroquinolone antibiotic indicated for bacterial infections. Sparfloxacin exerts its antibacterial activity by inhibiting DNA gyrase, a bacterial topoisomerase. DNA gyrase is an essential enzyme which controls DNA topology and assists in DNA replication, repair, deactivation, and transcription.
Approved
Investigational
Withdrawn
Matched Synonyms: … cis-5-Amino-1-cyclopropyl-7-(3,5-dimethyl-1-piperazinyl)-6,8-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic …
Matched Iupac: … -amino-1-cyclopropyl-7-[(3R,5S)-3,5-dimethylpiperazin-1-yl]-6,8-difluoro-4-oxo-1,4-dihydroquinoline-3- …
Matched Description: … deactivation, and transcription. ... Sparfloxacin is a fluoroquinolone antibiotic indicated for bacterial infections. ... Sparfloxacin exerts its antibacterial activity by inhibiting DNA gyrase, a bacterial topoisomerase. …
Matched Categories: … Heterocyclic Compounds, 2-Ring …
Matched Iupac: … -amino-1-cyclopropyl-7-[(3R,5S)-3,5-dimethylpiperazin-1-yl]-6,8-difluoro-4-oxo-1,4-dihydroquinoline-3- …
Matched Description: … deactivation, and transcription. ... Sparfloxacin is a fluoroquinolone antibiotic indicated for bacterial infections. ... Sparfloxacin exerts its antibacterial activity by inhibiting DNA gyrase, a bacterial topoisomerase. …
Matched Categories: … Heterocyclic Compounds, 2-Ring …
Dihydroergotamine
A 9,10alpha-dihydro derivative of ergotamine. Dihydroergotamine is used as an abortive therapy for migraines. Its use has largely been supplanted by triptans in current therapy due to the class's greater selectivity and more favourable side effect profile.
Recent improvements have been made in the design of intranasal delivery devices allowing...
Approved
Investigational
Matched Synonyms: … 5'-benzyl-12'-hydroxy-2'-methyl-3',6',18-trioxo-9,10-dihydroergotaman ... 9,10-dihydro-12'-hydroxy-2'-methyl-5'-(phenylmethyl)ergotoman-3',6',18-trione ... (2R,4R,7R)-N-[(1S,2S,4R,7S)-7-benzyl-2-hydroxy-4-methyl-5,8-dioxo-3-oxa-6,9-diazatricyclo[7.3.0.02,6] …
Matched Iupac: … (2R,4R,7R)-N-[(1S,2S,4R,7S)-7-benzyl-2-hydroxy-4-methyl-5,8-dioxo-3-oxa-6,9-diazatricyclo[7.3.0.0^{2,6 …
Matched Description: … technology has correlated with an increase of 3-fold in Cmax and 4-fold in AUC despite the solution ... A 9,10alpha-dihydro derivative of [ergotamine]. ... [A239569] The recently approved Precision Olfactory Delivery technology developed by Impel Neuropharma …
Matched Salts cas: … 6190-39-2 …
Matched Categories: … Ergot Alkaloids and Derivatives ... Cytochrome P-450 CYP3A4 Substrates with a Narrow Therapeutic Index …
Matched Iupac: … (2R,4R,7R)-N-[(1S,2S,4R,7S)-7-benzyl-2-hydroxy-4-methyl-5,8-dioxo-3-oxa-6,9-diazatricyclo[7.3.0.0^{2,6 …
Matched Description: … technology has correlated with an increase of 3-fold in Cmax and 4-fold in AUC despite the solution ... A 9,10alpha-dihydro derivative of [ergotamine]. ... [A239569] The recently approved Precision Olfactory Delivery technology developed by Impel Neuropharma …
Matched Salts cas: … 6190-39-2 …
Matched Categories: … Ergot Alkaloids and Derivatives ... Cytochrome P-450 CYP3A4 Substrates with a Narrow Therapeutic Index …
Ceritinib
Ceritinib is used for the treatment of adults with anaplastic lymphoma kinase (ALK)-positive metastatic non-small cell lung cancer (NSCLC) following failure (secondary to resistance or intolerance) of prior crizotinib therapy. About 4% of patients with NSCLC have a chromosomal rearrangement that generates a fusion gene between EML4 (echinoderm microtubule-associated protein-like...
Approved
Matched Synonyms: … N-{2-[(5-chloro-2-{[2-isopropoxy-5-methyl-4-(piperidin-4-yl)phenyl]amino}pyrimidin-4-yl)amino]phenyl} ... propane-2-sulfonamide …
Matched Iupac: … 5-chloro-N2-[5-methyl-4-(piperidin-4-yl)-2-(propan-2-yloxy)phenyl]-N4-[2-(propane-2-sulfonyl)phenyl]pyrimidine …
Matched Description: … The FDA approved ceritinib in April 2014 due to a surprisingly high response rate (56%) towards crizotinib-resistant ... About 4% of patients with NSCLC have a chromosomal rearrangement that generates a fusion gene between ... tumours and has designated it with orphan drug status. …
Matched Categories: … Antineoplastic and Immunomodulating Agents ... P-glycoprotein substrates with a Narrow Therapeutic Index ... Cytochrome P-450 CYP3A4 Substrates with a Narrow Therapeutic Index …
Matched Iupac: … 5-chloro-N2-[5-methyl-4-(piperidin-4-yl)-2-(propan-2-yloxy)phenyl]-N4-[2-(propane-2-sulfonyl)phenyl]pyrimidine …
Matched Description: … The FDA approved ceritinib in April 2014 due to a surprisingly high response rate (56%) towards crizotinib-resistant ... About 4% of patients with NSCLC have a chromosomal rearrangement that generates a fusion gene between ... tumours and has designated it with orphan drug status. …
Matched Categories: … Antineoplastic and Immunomodulating Agents ... P-glycoprotein substrates with a Narrow Therapeutic Index ... Cytochrome P-450 CYP3A4 Substrates with a Narrow Therapeutic Index …
Pentafluoropropane
Pentafluoropropane is under investigation in clinical trial NCT01673061 (Vapocoolant Spray for Numbing Small Boils Before Incision and Drainage).
Approved
Investigational
Matched Description: … investigation in clinical trial NCT01673061 (Vapocoolant Spray for Numbing Small Boils Before Incision and …
Benzonatate
Benzonatate is an oral antitussive drug used in the relief and suppression of cough in patients older than ten years of age. Currently, benzonatate is the only non-narcotic antitussive available as a prescription drug. It works to reduce the activity of cough reflex by desensitizing the tissues of the lungs...
Approved
Matched Synonyms: … 2-[2-[2-[2-[2-[2-[2-[2-(2-methoxyethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethyl 4-butylaminobenzoate …
Matched Description: … Benzonatate was approved by the FDA in 1958 under the market name Tessalon Perles. ... [A5790] Currently, benzonatate is the only non-narcotic antitussive available as a prescription drug. ... [L11193] Although it not prone to drug misuse or abuse, benzonatate is associated with a risk for severe …
Matched Categories: … Cough and Cold Preparations …
Matched Description: … Benzonatate was approved by the FDA in 1958 under the market name Tessalon Perles. ... [A5790] Currently, benzonatate is the only non-narcotic antitussive available as a prescription drug. ... [L11193] Although it not prone to drug misuse or abuse, benzonatate is associated with a risk for severe …
Matched Categories: … Cough and Cold Preparations …
Nivolumab
Nivolumab is a fully human IgG4 antibody targeting the immune checkpoint programmed death receptor-1 (PD-1). This antibody was produced entirely in mice and grafted onto human kappa and IgG4 Fc region with the mutation S228P for additional stability and reduced variability. It was developed by Bristol Myers Squibb. Nivolumab was...
Approved
Matched Description: … Nivolumab is a fully human IgG4 antibody targeting the immune checkpoint programmed death receptor-1 ... [L12129] It is also available in combination with [relatlimab] under the brand name Opdualag. ... [L12129] This antibody was produced entirely in mice and grafted onto human kappa and IgG4 Fc region …
Matched Categories: … nivolumab and relatlimab ... Amino Acids, Peptides, and Proteins ... Antineoplastic and Immunomodulating Agents ... MONOCLONAL ANTIBODIES AND ANTIBODY DRUG CONJUGATES …
Matched Categories: … nivolumab and relatlimab ... Amino Acids, Peptides, and Proteins ... Antineoplastic and Immunomodulating Agents ... MONOCLONAL ANTIBODIES AND ANTIBODY DRUG CONJUGATES …
Flotufolastat F-18
Flotufolastat F-18 (18F-rhPSMA-7.3) is an 18F-labeled ligand that targets the prostate-specific membrane antigen (PSMA).[A259846,L46731] In patients with recurrent prostate cancer that require localized treatment, the use of 18F-labeled ligands for positron emission tomography (PET) offers accurate diagnostic imaging. Unlike 68Ga-labeled PSMA-targeting ligands, 18F-labeled compounds targeting this protein have a longer...
Approved
Investigational
Matched Iupac: … (2S)-2-({[(1S)-1-carboxy-3-{[(1R)-1-carboxy-4-(3-{[(5R)-5-carboxy-5-[(2R)-2-[(4S)-4-carboxy-4-[4,7,10 ... -tris(carboxymethyl)-1,4,7,10-tetraazacyclododecan-1-yl]butanamido]-3-({4-[di-tert-butyl((18F)fluoro) …
Matched Description: … of this compound, flotufolastat F-18 has a faster clearance from blood pool, liver, and kidney, and ... a good distinction between primary-tumor activity and bladder background activity. ... Flotufolastat F-18 is a diastereoisomer of 18F-rhPSMA-7, and compared to the other diastereoisomers …
Matched Description: … of this compound, flotufolastat F-18 has a faster clearance from blood pool, liver, and kidney, and ... a good distinction between primary-tumor activity and bladder background activity. ... Flotufolastat F-18 is a diastereoisomer of 18F-rhPSMA-7, and compared to the other diastereoisomers …
Cromoglicic acid
A chromone complex that acts by inhibiting the release of chemical mediators from sensitized mast cells. It is used in the prophylactic treatment of both allergic and exercise-induced asthma, but does not affect an established asthmatic attack.
Approved
Matched Synonyms: … 5-[3-(2-carboxy-4-oxo-4H-5-chromenyloxy)-2-hydroxypropoxy]-4-oxo-4H-2-chromenecarboxylic acid …
Matched Iupac: … 5-{3-[(2-carboxy-4-oxo-4H-chromen-5-yl)oxy]-2-hydroxypropoxy}-4-oxo-4H-chromene-2-carboxylic acid …
Matched Description: … A chromone complex that acts by inhibiting the release of chemical mediators from sensitized mast cells ... It is used in the prophylactic treatment of both allergic and exercise-induced asthma, but does not affect …
Matched Categories: … Heterocyclic Compounds, 2-Ring ... Alimentary Tract and Metabolism ... Decongestants and Antiallergics ... reproterol and sodium cromoglicate ... salbutamol and sodium cromoglicate …
Matched Products: … CONVER 2% ... OSMOCROM 2% ... CROMISOL 2% …
Matched Iupac: … 5-{3-[(2-carboxy-4-oxo-4H-chromen-5-yl)oxy]-2-hydroxypropoxy}-4-oxo-4H-chromene-2-carboxylic acid …
Matched Description: … A chromone complex that acts by inhibiting the release of chemical mediators from sensitized mast cells ... It is used in the prophylactic treatment of both allergic and exercise-induced asthma, but does not affect …
Matched Categories: … Heterocyclic Compounds, 2-Ring ... Alimentary Tract and Metabolism ... Decongestants and Antiallergics ... reproterol and sodium cromoglicate ... salbutamol and sodium cromoglicate …
Matched Products: … CONVER 2% ... OSMOCROM 2% ... CROMISOL 2% …
Naratriptan
Naratriptan is a triptan drug that is selective for the 5-hydroxytryptamine1 receptor subtype. It is typically used for the treatment of migraine headaches.
Approved
Investigational
Matched Synonyms: … N-methyl-2-(3-(1-methylpiperiden-4-yl)indole-5-yl)ethanesulfonamide ... N-methyl-2-[3-(1-methyl-4-piperidyl)-1H-indol-5-yl]-ethanesulfonamide …
Matched Iupac: … N-methyl-2-[3-(1-methylpiperidin-4-yl)-1H-indol-5-yl]ethane-1-sulfonamide …
Matched Description: … Naratriptan is a triptan drug that is selective for the 5-hydroxytryptamine1 receptor subtype. …
Matched Categories: … Heterocyclic Compounds, 2-Ring ... Monoamine Oxidase A Substrates ... Serotonin-1b and Serotonin-1d Receptor Agonist …
Matched Products: … NARAMIG 2.5 MG FILM TABLET, 2 ADET …
Matched Iupac: … N-methyl-2-[3-(1-methylpiperidin-4-yl)-1H-indol-5-yl]ethane-1-sulfonamide …
Matched Description: … Naratriptan is a triptan drug that is selective for the 5-hydroxytryptamine1 receptor subtype. …
Matched Categories: … Heterocyclic Compounds, 2-Ring ... Monoamine Oxidase A Substrates ... Serotonin-1b and Serotonin-1d Receptor Agonist …
Matched Products: … NARAMIG 2.5 MG FILM TABLET, 2 ADET …
Tirofiban
Tirofiban prevents the blood from clotting during episodes of chest pain or a heart attack, or while the patient is undergoing a procedure to treat a blocked coronary artery. It is a non-peptide reversible antagonist of the platelet glycoprotein (GP) IIb/IIIa receptor, and inhibits platelet aggregation.
Approved
Matched Synonyms: … (2S)-2-(butylsulfonylamino)-3-[4-(4-piperidin-4-ylbutoxy)phenyl]propanoic acid …
Matched Iupac: … (2S)-2-(butane-1-sulfonamido)-3-{4-[4-(piperidin-4-yl)butoxy]phenyl}propanoic acid …
Matched Description: … It is a non-peptide reversible antagonist of the platelet glycoprotein (GP) IIb/IIIa receptor, and inhibits ... the patient is undergoing a procedure to treat a blocked coronary artery. ... Tirofiban prevents the blood from clotting during episodes of chest pain or a heart attack, or while …
Matched Categories: … Blood and Blood Forming Organs ... Amino Acids, Peptides, and Proteins …
Matched Iupac: … (2S)-2-(butane-1-sulfonamido)-3-{4-[4-(piperidin-4-yl)butoxy]phenyl}propanoic acid …
Matched Description: … It is a non-peptide reversible antagonist of the platelet glycoprotein (GP) IIb/IIIa receptor, and inhibits ... the patient is undergoing a procedure to treat a blocked coronary artery. ... Tirofiban prevents the blood from clotting during episodes of chest pain or a heart attack, or while …
Matched Categories: … Blood and Blood Forming Organs ... Amino Acids, Peptides, and Proteins …
Displaying drugs 251 - 275 of 5107 in total