Identification

Name
Perampanel
Accession Number
DB08883
Type
Small Molecule
Groups
Approved
Description

Perampanel is a noncompetitive AMPA glutamate receptor antagonist. It is marketed under the name Fycompa™ and is indicated as an adjunct in patients over 12 years old for the treatment of partial-onset seizures that may or may not occur with generalized seizures. The FDA label includes an important black-boxed warning of serious or life-threatening behavioral and psychiatric reactions in patients taking Fycompa™.

Structure
Thumb
Synonyms
  • 3-(2-Cyanophenyl)-5-(2-pyridyl)-1-phenyl-1,2-dihydropyridin-2-one
  • perampanel
  • pérampanel
  • Perampanelum
External IDs
E-2007 / E2007 / ER-155055-90
Product Ingredients
IngredientUNIICASInChI Key
Perampanel hydrate8LIX22217M1571982-04-1PDWMJDKMSASBNE-UHFFFAOYSA-N
Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
FycompaTablet, film coated6 mgOralEisai Europe Ltd2012-07-23Not applicableEu
FycompaTablet, film coated4 mgOralEisai Europe Ltd2012-07-23Not applicableEu
FycompaTablet, film coated12 mgOralEisai Europe Ltd2012-07-23Not applicableEu
FycompaTablet, film coated2 mgOralEisai Europe Ltd2012-07-23Not applicableEu
FycompaSuspension.5 mg/mLOralEisai Limited2016-04-30Not applicableUs
FycompaTablet6 mg/1OralEisai Limited2012-10-22Not applicableUs
FycompaKitEisai Limited2012-10-222016-10-13Us
FycompaTablet, film coated8 mgOralEisai Europe Ltd2012-07-23Not applicableEu
FycompaTablet12 mg/1OralEisai Limited2012-10-22Not applicableUs
FycompaTablet4.0 mgOralEisai Limited2013-06-19Not applicableCanada
Categories
UNII
H821664NPK
CAS number
380917-97-5
Weight
Average: 349.393
Monoisotopic: 349.121512115
Chemical Formula
C23H15N3O
InChI Key
PRMWGUBFXWROHD-UHFFFAOYSA-N
InChI
InChI=1S/C23H15N3O/c24-15-17-8-4-5-11-20(17)21-14-18(22-12-6-7-13-25-22)16-26(23(21)27)19-9-2-1-3-10-19/h1-14,16H
IUPAC Name
2-{6'-oxo-1'-phenyl-1',6'-dihydro-[2,3'-bipyridine]-5'-yl}benzonitrile
SMILES
O=C1N(C=C(C=C1C1=CC=CC=C1C#N)C1=NC=CC=C1)C1=CC=CC=C1

Pharmacology

Indication

Used in patients over 12 years old for the treatment of partial-onset seizures that may or may not occur with generalized seizures.

Structured Indications
Pharmacodynamics

Perampanel is involved in inhibiting neuronal excitation in the central nervous system leading to such effects as decreased pyschomotor performance.

Mechanism of action

The exact mechanism of action of perampanel in seizures is not yet determined, but it is known that perampanel decreases neuronal excitation by non-competitive ihibition of the AMPA receptor.

TargetActionsOrganism
AGlutamate receptor 1
antagonist
Human
Absorption

After oral adminitration, perampanel is absorbed rapidly and completely.

Volume of distribution

The volume of distribution of perampanel was not quantified.

Protein binding

Perampanel is 95-96% plasma protein bound with most binding to the plasma proteins α1-acid glycoprotein and albumin.

Metabolism

Perampanel is highly metabolized by CYP3A4 and/or CYP3A5 primary oxidation and by sequential glucuronidation.

Route of elimination

Perampanel is eliminated mostely in the feces (48%) and to a lesser exten in the urine (22%).

Half life

Perampanel has a long elmination half-life of about 105 hours.

Clearance

In healthy patients, perampanel has a clearance of about 12 mL/min.

Toxicity

The FDA label includes an important warning of serious or life-threatening behavioral and psychiatric adverse reactions including aggression, hostility, irritability, anger, and homicidal thoughts in patients taking perampanel.

Affected organisms
  • Humans and other mammals
Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
DrugInteractionDrug group
7-NitroindazolePerampanel may increase the central nervous system depressant (CNS depressant) activities of 7-Nitroindazole.Experimental
AcepromazinePerampanel may increase the central nervous system depressant (CNS depressant) activities of Acepromazine.Approved, Vet Approved
AceprometazinePerampanel may increase the central nervous system depressant (CNS depressant) activities of Aceprometazine.Approved
AdipiplonPerampanel may increase the central nervous system depressant (CNS depressant) activities of Adipiplon.Investigational
AgomelatinePerampanel may increase the central nervous system depressant (CNS depressant) activities of Agomelatine.Approved, Investigational
AlaproclateThe risk or severity of adverse effects can be increased when Perampanel is combined with Alaproclate.Experimental
AlfaxalonePerampanel may increase the central nervous system depressant (CNS depressant) activities of Alfaxalone.Vet Approved
AlfentanilPerampanel may increase the central nervous system depressant (CNS depressant) activities of Alfentanil.Approved, Illicit
AllopregnanolonePerampanel may increase the central nervous system depressant (CNS depressant) activities of Allopregnanolone.Investigational
AlphacetylmethadolPerampanel may increase the central nervous system depressant (CNS depressant) activities of Alphacetylmethadol.Experimental, Illicit
AlphaprodinePerampanel may increase the central nervous system depressant (CNS depressant) activities of Alphaprodine.Illicit
AlprazolamPerampanel may increase the central nervous system depressant (CNS depressant) activities of Alprazolam.Approved, Illicit, Investigational
AmiodaroneThe metabolism of Perampanel can be decreased when combined with Amiodarone.Approved, Investigational
AmisulpridePerampanel may increase the central nervous system depressant (CNS depressant) activities of Amisulpride.Approved, Investigational
AmitriptylinePerampanel may increase the central nervous system depressant (CNS depressant) activities of Amitriptyline.Approved
AmobarbitalPerampanel may increase the central nervous system depressant (CNS depressant) activities of Amobarbital.Approved, Illicit
AmoxapinePerampanel may increase the central nervous system depressant (CNS depressant) activities of Amoxapine.Approved
AmperozidePerampanel may increase the central nervous system depressant (CNS depressant) activities of Amperozide.Experimental
AprepitantThe serum concentration of Perampanel can be increased when it is combined with Aprepitant.Approved, Investigational
AripiprazolePerampanel may increase the central nervous system depressant (CNS depressant) activities of Aripiprazole.Approved, Investigational
ArticainePerampanel may increase the central nervous system depressant (CNS depressant) activities of Articaine.Approved
AsenapinePerampanel may increase the central nervous system depressant (CNS depressant) activities of Asenapine.Approved
AtazanavirThe metabolism of Perampanel can be decreased when combined with Atazanavir.Approved, Investigational
AtomoxetineThe metabolism of Perampanel can be decreased when combined with Atomoxetine.Approved
AzaperonePerampanel may increase the central nervous system depressant (CNS depressant) activities of Azaperone.Investigational, Vet Approved
AzelastinePerampanel may increase the central nervous system depressant (CNS depressant) activities of Azelastine.Approved
BaclofenPerampanel may increase the central nervous system depressant (CNS depressant) activities of Baclofen.Approved
BarbitalPerampanel may increase the central nervous system depressant (CNS depressant) activities of Barbital.Illicit
BenperidolPerampanel may increase the central nervous system depressant (CNS depressant) activities of Benperidol.Investigational
BenzocainePerampanel may increase the central nervous system depressant (CNS depressant) activities of Benzocaine.Approved
Benzyl alcoholPerampanel may increase the central nervous system depressant (CNS depressant) activities of Benzyl alcohol.Approved
BoceprevirThe metabolism of Perampanel can be decreased when combined with Boceprevir.Approved, Withdrawn
BortezomibThe metabolism of Perampanel can be decreased when combined with Bortezomib.Approved, Investigational
BosentanThe serum concentration of Perampanel can be decreased when it is combined with Bosentan.Approved, Investigational
BrexpiprazolePerampanel may increase the central nervous system depressant (CNS depressant) activities of Brexpiprazole.Approved
BrimonidinePerampanel may increase the central nervous system depressant (CNS depressant) activities of Brimonidine.Approved
BromazepamPerampanel may increase the central nervous system depressant (CNS depressant) activities of Bromazepam.Approved, Illicit
BromisovalPerampanel may increase the central nervous system depressant (CNS depressant) activities of Bromisoval.Experimental
BromperidolPerampanel may increase the central nervous system depressant (CNS depressant) activities of Bromperidol.Investigational
BrompheniraminePerampanel may increase the central nervous system depressant (CNS depressant) activities of Brompheniramine.Approved
BrotizolamPerampanel may increase the central nervous system depressant (CNS depressant) activities of Brotizolam.Approved, Investigational, Withdrawn
BupivacainePerampanel may increase the central nervous system depressant (CNS depressant) activities of Bupivacaine.Approved, Investigational
BuprenorphinePerampanel may increase the central nervous system depressant (CNS depressant) activities of Buprenorphine.Approved, Illicit, Investigational, Vet Approved
BuspironePerampanel may increase the central nervous system depressant (CNS depressant) activities of Buspirone.Approved, Investigational
ButabarbitalPerampanel may increase the central nervous system depressant (CNS depressant) activities of Butabarbital.Approved, Illicit
ButacainePerampanel may increase the central nervous system depressant (CNS depressant) activities of Butacaine.Vet Approved
ButalbitalPerampanel may increase the central nervous system depressant (CNS depressant) activities of Butalbital.Approved, Illicit
ButambenPerampanel may increase the central nervous system depressant (CNS depressant) activities of Butamben.Approved
ButethalPerampanel may increase the central nervous system depressant (CNS depressant) activities of Butethal.Approved, Illicit
ButorphanolPerampanel may increase the central nervous system depressant (CNS depressant) activities of Butorphanol.Approved, Illicit, Vet Approved
CanertinibPerampanel may increase the central nervous system depressant (CNS depressant) activities of Canertinib.Investigational
CarbamazepineThe serum concentration of Perampanel can be decreased when it is combined with Carbamazepine.Approved, Investigational
CarbinoxaminePerampanel may increase the central nervous system depressant (CNS depressant) activities of Carbinoxamine.Approved
CarfentanilPerampanel may increase the central nervous system depressant (CNS depressant) activities of Carfentanil.Illicit, Investigational, Vet Approved
CarisoprodolPerampanel may increase the central nervous system depressant (CNS depressant) activities of Carisoprodol.Approved
CeritinibThe serum concentration of Perampanel can be increased when it is combined with Ceritinib.Approved
CetirizinePerampanel may increase the central nervous system depressant (CNS depressant) activities of Cetirizine.Approved
Chloral hydratePerampanel may increase the central nervous system depressant (CNS depressant) activities of Chloral hydrate.Approved, Illicit, Vet Approved
ChlordiazepoxidePerampanel may increase the central nervous system depressant (CNS depressant) activities of Chlordiazepoxide.Approved, Illicit
ChlormezanonePerampanel may increase the central nervous system depressant (CNS depressant) activities of Chlormezanone.Approved, Investigational, Withdrawn
ChloroprocainePerampanel may increase the central nervous system depressant (CNS depressant) activities of Chloroprocaine.Approved
ChlorphenaminePerampanel may increase the central nervous system depressant (CNS depressant) activities of Chlorphenamine.Approved
ChlorpromazinePerampanel may increase the central nervous system depressant (CNS depressant) activities of Chlorpromazine.Approved, Vet Approved
ChlorprothixenePerampanel may increase the central nervous system depressant (CNS depressant) activities of Chlorprothixene.Approved, Investigational, Withdrawn
ChlorzoxazonePerampanel may increase the central nervous system depressant (CNS depressant) activities of Chlorzoxazone.Approved
CinchocainePerampanel may increase the central nervous system depressant (CNS depressant) activities of Cinchocaine.Approved, Vet Approved
CitalopramThe risk or severity of adverse effects can be increased when Perampanel is combined with Citalopram.Approved
ClarithromycinThe metabolism of Perampanel can be decreased when combined with Clarithromycin.Approved
ClemastinePerampanel may increase the central nervous system depressant (CNS depressant) activities of Clemastine.Approved
ClidiniumPerampanel may increase the central nervous system depressant (CNS depressant) activities of Clidinium.Approved
ClobazamPerampanel may increase the central nervous system depressant (CNS depressant) activities of Clobazam.Approved, Illicit
clomethiazolePerampanel may increase the central nervous system depressant (CNS depressant) activities of clomethiazole.Investigational
ClomipraminePerampanel may increase the central nervous system depressant (CNS depressant) activities of Clomipramine.Approved, Vet Approved
ClonazepamPerampanel may increase the central nervous system depressant (CNS depressant) activities of Clonazepam.Approved, Illicit
ClonidinePerampanel may increase the central nervous system depressant (CNS depressant) activities of Clonidine.Approved
ClopenthixolPerampanel may increase the central nervous system depressant (CNS depressant) activities of Clopenthixol.Experimental
ClorazepatePerampanel may increase the central nervous system depressant (CNS depressant) activities of Clorazepate.Approved, Illicit
ClothiapinePerampanel may increase the central nervous system depressant (CNS depressant) activities of Clothiapine.Experimental
ClotrimazoleThe metabolism of Perampanel can be decreased when combined with Clotrimazole.Approved, Vet Approved
ClozapinePerampanel may increase the central nervous system depressant (CNS depressant) activities of Clozapine.Approved
CobicistatThe metabolism of Perampanel can be decreased when combined with Cobicistat.Approved
CocainePerampanel may increase the central nervous system depressant (CNS depressant) activities of Cocaine.Approved, Illicit
CodeinePerampanel may increase the central nervous system depressant (CNS depressant) activities of Codeine.Approved, Illicit
ConivaptanThe serum concentration of Perampanel can be increased when it is combined with Conivaptan.Approved, Investigational
CrizotinibThe metabolism of Perampanel can be decreased when combined with Crizotinib.Approved
CyclizinePerampanel may increase the central nervous system depressant (CNS depressant) activities of Cyclizine.Approved
CyclobenzaprinePerampanel may increase the central nervous system depressant (CNS depressant) activities of Cyclobenzaprine.Approved
CyclosporineThe metabolism of Perampanel can be decreased when combined with Cyclosporine.Approved, Investigational, Vet Approved
CyproheptadinePerampanel may increase the central nervous system depressant (CNS depressant) activities of Cyproheptadine.Approved
DabrafenibThe serum concentration of Perampanel can be decreased when it is combined with Dabrafenib.Approved
DantrolenePerampanel may increase the central nervous system depressant (CNS depressant) activities of Dantrolene.Approved
DapiprazolePerampanel may increase the central nervous system depressant (CNS depressant) activities of Dapiprazole.Approved
DapoxetineThe risk or severity of adverse effects can be increased when Perampanel is combined with Dapoxetine.Investigational
DarunavirThe metabolism of Perampanel can be decreased when combined with Darunavir.Approved
DasatinibThe serum concentration of Perampanel can be increased when it is combined with Dasatinib.Approved, Investigational
DeferasiroxThe serum concentration of Perampanel can be decreased when it is combined with Deferasirox.Approved, Investigational
DelavirdineThe metabolism of Perampanel can be decreased when combined with Delavirdine.Approved
DeramciclanePerampanel may increase the central nervous system depressant (CNS depressant) activities of Deramciclane.Investigational
DesfluranePerampanel may increase the central nervous system depressant (CNS depressant) activities of Desflurane.Approved
DesipraminePerampanel may increase the central nervous system depressant (CNS depressant) activities of Desipramine.Approved
DesloratadinePerampanel may increase the central nervous system depressant (CNS depressant) activities of Desloratadine.Approved, Investigational
DesogestrelThe serum concentration of Desogestrel can be decreased when it is combined with Perampanel.Approved
DesvenlafaxineThe risk or severity of adverse effects can be increased when Perampanel is combined with Desvenlafaxine.Approved
DetomidinePerampanel may increase the central nervous system depressant (CNS depressant) activities of Detomidine.Vet Approved
DexbrompheniraminePerampanel may increase the central nervous system depressant (CNS depressant) activities of Dexbrompheniramine.Approved
DexmedetomidinePerampanel may increase the central nervous system depressant (CNS depressant) activities of Dexmedetomidine.Approved, Vet Approved
DextromoramidePerampanel may increase the central nervous system depressant (CNS depressant) activities of Dextromoramide.Experimental, Illicit
DextropropoxyphenePerampanel may increase the central nervous system depressant (CNS depressant) activities of Dextropropoxyphene.Approved, Illicit, Investigational, Withdrawn
DezocinePerampanel may increase the central nervous system depressant (CNS depressant) activities of Dezocine.Approved, Investigational
DiazepamPerampanel may increase the central nervous system depressant (CNS depressant) activities of Diazepam.Approved, Illicit, Vet Approved
DienogestThe serum concentration of Dienogest can be decreased when it is combined with Perampanel.Approved
Diethyl etherPerampanel may increase the central nervous system depressant (CNS depressant) activities of Diethyl ether.Experimental
DifenoxinPerampanel may increase the central nervous system depressant (CNS depressant) activities of Difenoxin.Approved, Illicit
DihydrocodeinePerampanel may increase the central nervous system depressant (CNS depressant) activities of Dihydrocodeine.Approved, Illicit
DihydroergotamineThe metabolism of Perampanel can be decreased when combined with Dihydroergotamine.Approved
DihydroetorphinePerampanel may increase the central nervous system depressant (CNS depressant) activities of Dihydroetorphine.Experimental, Illicit
DihydromorphinePerampanel may increase the central nervous system depressant (CNS depressant) activities of Dihydromorphine.Experimental, Illicit
DiltiazemThe metabolism of Perampanel can be decreased when combined with Diltiazem.Approved
DimenhydrinatePerampanel may increase the central nervous system depressant (CNS depressant) activities of Dimenhydrinate.Approved
DiphenhydraminePerampanel may increase the central nervous system depressant (CNS depressant) activities of Diphenhydramine.Approved
DiphenoxylatePerampanel may increase the central nervous system depressant (CNS depressant) activities of Diphenoxylate.Approved, Illicit
DixyrazinePerampanel may increase the central nervous system depressant (CNS depressant) activities of Dixyrazine.Experimental
DoramectinPerampanel may increase the central nervous system depressant (CNS depressant) activities of Doramectin.Vet Approved
DoxepinPerampanel may increase the central nervous system depressant (CNS depressant) activities of Doxepin.Approved
DoxycyclineThe metabolism of Perampanel can be decreased when combined with Doxycycline.Approved, Investigational, Vet Approved
DoxylaminePerampanel may increase the central nervous system depressant (CNS depressant) activities of Doxylamine.Approved, Vet Approved
DPDPEPerampanel may increase the central nervous system depressant (CNS depressant) activities of DPDPE.Investigational
DronabinolDronabinol may increase the central nervous system depressant (CNS depressant) activities of Perampanel.Approved, Illicit
DronedaroneThe metabolism of Perampanel can be decreased when combined with Dronedarone.Approved
DroperidolDroperidol may increase the central nervous system depressant (CNS depressant) activities of Perampanel.Approved, Vet Approved
DrospirenoneThe serum concentration of Drospirenone can be decreased when it is combined with Perampanel.Approved
DrotebanolPerampanel may increase the central nervous system depressant (CNS depressant) activities of Drotebanol.Experimental, Illicit
DuloxetineThe risk or severity of adverse effects can be increased when Perampanel is combined with Duloxetine.Approved
DycloninePerampanel may increase the central nervous system depressant (CNS depressant) activities of Dyclonine.Approved
EcgoninePerampanel may increase the central nervous system depressant (CNS depressant) activities of Ecgonine.Experimental, Illicit
EcopipamPerampanel may increase the central nervous system depressant (CNS depressant) activities of Ecopipam.Investigational
EfavirenzPerampanel may increase the central nervous system depressant (CNS depressant) activities of Efavirenz.Approved, Investigational
EltanolonePerampanel may increase the central nervous system depressant (CNS depressant) activities of Eltanolone.Investigational
EnfluranePerampanel may increase the central nervous system depressant (CNS depressant) activities of Enflurane.Approved, Investigational, Vet Approved
EntacaponePerampanel may increase the central nervous system depressant (CNS depressant) activities of Entacapone.Approved, Investigational
ErythromycinThe metabolism of Perampanel can be decreased when combined with Erythromycin.Approved, Vet Approved
EscitalopramThe risk or severity of adverse effects can be increased when Perampanel is combined with Escitalopram.Approved, Investigational
EstazolamPerampanel may increase the central nervous system depressant (CNS depressant) activities of Estazolam.Approved, Illicit
EszopiclonePerampanel may increase the central nervous system depressant (CNS depressant) activities of Eszopiclone.Approved
EthanolPerampanel may increase the central nervous system depressant (CNS depressant) activities of Ethanol.Approved
EthchlorvynolPerampanel may increase the central nervous system depressant (CNS depressant) activities of Ethchlorvynol.Approved, Illicit, Withdrawn
EthosuximidePerampanel may increase the central nervous system depressant (CNS depressant) activities of Ethosuximide.Approved
EthotoinPerampanel may increase the central nervous system depressant (CNS depressant) activities of Ethotoin.Approved
Ethyl carbamatePerampanel may increase the central nervous system depressant (CNS depressant) activities of Ethyl carbamate.Withdrawn
Ethyl chloridePerampanel may increase the central nervous system depressant (CNS depressant) activities of Ethyl chloride.Experimental, Investigational
Ethyl loflazepatePerampanel may increase the central nervous system depressant (CNS depressant) activities of Ethyl loflazepate.Approved, Illicit
EthylmorphinePerampanel may increase the central nervous system depressant (CNS depressant) activities of Ethylmorphine.Approved, Illicit
Ethynodiol diacetateThe serum concentration of Ethynodiol diacetate can be decreased when it is combined with Perampanel.Approved
EtidocainePerampanel may increase the central nervous system depressant (CNS depressant) activities of Etidocaine.Approved
EtifoxinePerampanel may increase the central nervous system depressant (CNS depressant) activities of Etifoxine.Investigational, Withdrawn
EtizolamPerampanel may increase the central nervous system depressant (CNS depressant) activities of Etizolam.Approved
EtomidatePerampanel may increase the central nervous system depressant (CNS depressant) activities of Etomidate.Approved
EtonogestrelThe serum concentration of Etonogestrel can be decreased when it is combined with Perampanel.Approved, Investigational
EtoperidoneThe risk or severity of adverse effects can be increased when Perampanel is combined with Etoperidone.Withdrawn
EtorphinePerampanel may increase the central nervous system depressant (CNS depressant) activities of Etorphine.Illicit, Vet Approved
EzogabinePerampanel may increase the central nervous system depressant (CNS depressant) activities of Ezogabine.Approved
FelbamatePerampanel may increase the central nervous system depressant (CNS depressant) activities of Felbamate.Approved
FencamfaminePerampanel may increase the central nervous system depressant (CNS depressant) activities of Fencamfamine.Approved, Illicit, Withdrawn
FentanylPerampanel may increase the central nervous system depressant (CNS depressant) activities of Fentanyl.Approved, Illicit, Investigational, Vet Approved
FexofenadinePerampanel may increase the central nervous system depressant (CNS depressant) activities of Fexofenadine.Approved
FlibanserinPerampanel may increase the central nervous system depressant (CNS depressant) activities of Flibanserin.Approved
FluanisonePerampanel may increase the central nervous system depressant (CNS depressant) activities of Fluanisone.Experimental
FluconazoleThe metabolism of Perampanel can be decreased when combined with Fluconazole.Approved
FludiazepamPerampanel may increase the central nervous system depressant (CNS depressant) activities of Fludiazepam.Approved, Illicit
FlunarizinePerampanel may increase the central nervous system depressant (CNS depressant) activities of Flunarizine.Approved
FlunitrazepamPerampanel may increase the central nervous system depressant (CNS depressant) activities of Flunitrazepam.Approved, Illicit
FluoxetineThe risk or severity of adverse effects can be increased when Perampanel is combined with Fluoxetine.Approved, Vet Approved
FlupentixolPerampanel may increase the central nervous system depressant (CNS depressant) activities of Flupentixol.Approved, Withdrawn
FluphenazinePerampanel may increase the central nervous system depressant (CNS depressant) activities of Fluphenazine.Approved
FlurazepamPerampanel may increase the central nervous system depressant (CNS depressant) activities of Flurazepam.Approved, Illicit
FluspirilenePerampanel may increase the central nervous system depressant (CNS depressant) activities of Fluspirilene.Approved, Investigational
Fluticasone propionatePerampanel may increase the central nervous system depressant (CNS depressant) activities of Fluticasone propionate.Approved
FluvoxaminePerampanel may increase the central nervous system depressant (CNS depressant) activities of Fluvoxamine.Approved, Investigational
FosamprenavirThe metabolism of Perampanel can be decreased when combined with Fosamprenavir.Approved
FosaprepitantThe serum concentration of Perampanel can be increased when it is combined with Fosaprepitant.Approved
FosphenytoinThe serum concentration of Perampanel can be decreased when it is combined with Fosphenytoin.Approved
FospropofolPerampanel may increase the central nervous system depressant (CNS depressant) activities of Fospropofol.Approved, Illicit, Investigational
Fusidic AcidThe serum concentration of Perampanel can be increased when it is combined with Fusidic Acid.Approved
GabapentinPerampanel may increase the central nervous system depressant (CNS depressant) activities of Gabapentin.Approved, Investigational
Gabapentin EnacarbilPerampanel may increase the central nervous system depressant (CNS depressant) activities of Gabapentin Enacarbil.Approved
Gamma Hydroxybutyric AcidPerampanel may increase the central nervous system depressant (CNS depressant) activities of Gamma Hydroxybutyric Acid.Approved, Illicit, Investigational
GepironePerampanel may increase the central nervous system depressant (CNS depressant) activities of Gepirone.Investigational
GestodeneThe serum concentration of Gestodene can be decreased when it is combined with Perampanel.Approved, Investigational
GlutethimidePerampanel may increase the central nervous system depressant (CNS depressant) activities of Glutethimide.Approved, Illicit
GuanfacinePerampanel may increase the central nervous system depressant (CNS depressant) activities of Guanfacine.Approved, Investigational
HalazepamPerampanel may increase the central nervous system depressant (CNS depressant) activities of Halazepam.Approved, Illicit, Withdrawn
HaloperidolPerampanel may increase the central nervous system depressant (CNS depressant) activities of Haloperidol.Approved
HalothanePerampanel may increase the central nervous system depressant (CNS depressant) activities of Halothane.Approved, Vet Approved
HeroinPerampanel may increase the central nervous system depressant (CNS depressant) activities of Heroin.Approved, Illicit, Investigational
HexobarbitalPerampanel may increase the central nervous system depressant (CNS depressant) activities of Hexobarbital.Approved
HydrocodonePerampanel may increase the central nervous system depressant (CNS depressant) activities of Hydrocodone.Approved, Illicit
HydromorphonePerampanel may increase the central nervous system depressant (CNS depressant) activities of Hydromorphone.Approved, Illicit
HydroxyzinePerampanel may increase the central nervous system depressant (CNS depressant) activities of Hydroxyzine.Approved
IdelalisibThe serum concentration of Perampanel can be increased when it is combined with Idelalisib.Approved
IloperidonePerampanel may increase the central nervous system depressant (CNS depressant) activities of Iloperidone.Approved
ImatinibThe metabolism of Perampanel can be decreased when combined with Imatinib.Approved
ImipraminePerampanel may increase the central nervous system depressant (CNS depressant) activities of Imipramine.Approved
IndalpineThe risk or severity of adverse effects can be increased when Perampanel is combined with Indalpine.Investigational, Withdrawn
IndinavirThe metabolism of Perampanel can be decreased when combined with Indinavir.Approved
IndiplonPerampanel may increase the central nervous system depressant (CNS depressant) activities of Indiplon.Investigational
IsavuconazoniumThe metabolism of Perampanel can be decreased when combined with Isavuconazonium.Approved, Investigational
IsofluranePerampanel may increase the central nervous system depressant (CNS depressant) activities of Isoflurane.Approved, Vet Approved
IsradipineThe metabolism of Perampanel can be decreased when combined with Isradipine.Approved
ItraconazoleThe metabolism of Perampanel can be decreased when combined with Itraconazole.Approved, Investigational
IvacaftorThe serum concentration of Perampanel can be increased when it is combined with Ivacaftor.Approved
KetaminePerampanel may increase the central nervous system depressant (CNS depressant) activities of Ketamine.Approved, Vet Approved
KetazolamPerampanel may increase the central nervous system depressant (CNS depressant) activities of Ketazolam.Approved
KetobemidonePerampanel may increase the central nervous system depressant (CNS depressant) activities of Ketobemidone.Approved, Investigational
KetoconazoleThe metabolism of Perampanel can be decreased when combined with Ketoconazole.Approved, Investigational
LamotriginePerampanel may increase the central nervous system depressant (CNS depressant) activities of Lamotrigine.Approved, Investigational
LevetiracetamPerampanel may increase the central nervous system depressant (CNS depressant) activities of Levetiracetam.Approved, Investigational
LevobupivacainePerampanel may increase the central nervous system depressant (CNS depressant) activities of Levobupivacaine.Approved, Investigational
LevocabastinePerampanel may increase the central nervous system depressant (CNS depressant) activities of Levocabastine.Approved
LevocetirizinePerampanel may increase the central nervous system depressant (CNS depressant) activities of Levocetirizine.Approved
LevodopaPerampanel may increase the central nervous system depressant (CNS depressant) activities of Levodopa.Approved
Levomethadyl AcetatePerampanel may increase the central nervous system depressant (CNS depressant) activities of Levomethadyl Acetate.Approved, Investigational
LevomilnacipranThe risk or severity of adverse effects can be increased when Perampanel is combined with Levomilnacipran.Approved
LevonorgestrelThe serum concentration of Levonorgestrel can be decreased when it is combined with Perampanel.Approved, Investigational
LevorphanolPerampanel may increase the central nervous system depressant (CNS depressant) activities of Levorphanol.Approved
LidocainePerampanel may increase the central nervous system depressant (CNS depressant) activities of Lidocaine.Approved, Vet Approved
LithiumPerampanel may increase the central nervous system depressant (CNS depressant) activities of Lithium.Approved
LofentanilPerampanel may increase the central nervous system depressant (CNS depressant) activities of Lofentanil.Illicit
LopinavirThe metabolism of Perampanel can be decreased when combined with Lopinavir.Approved
LoprazolamPerampanel may increase the central nervous system depressant (CNS depressant) activities of Loprazolam.Experimental
LoratadinePerampanel may increase the central nervous system depressant (CNS depressant) activities of Loratadine.Approved
LorazepamPerampanel may increase the central nervous system depressant (CNS depressant) activities of Lorazepam.Approved
LormetazepamPerampanel may increase the central nervous system depressant (CNS depressant) activities of Lormetazepam.Approved
LovastatinThe metabolism of Perampanel can be decreased when combined with Lovastatin.Approved, Investigational
LoxapinePerampanel may increase the central nervous system depressant (CNS depressant) activities of Loxapine.Approved
LuliconazoleThe serum concentration of Perampanel can be increased when it is combined with Luliconazole.Approved
LumacaftorThe serum concentration of Perampanel can be decreased when it is combined with Lumacaftor.Approved
LurasidonePerampanel may increase the central nervous system depressant (CNS depressant) activities of Lurasidone.Approved
LynestrenolThe serum concentration of Lynestrenol can be decreased when it is combined with Perampanel.Investigational
Magnesium SulfatePerampanel may increase the central nervous system depressant (CNS depressant) activities of Magnesium Sulfate.Approved, Vet Approved
MaprotilinePerampanel may increase the central nervous system depressant (CNS depressant) activities of Maprotiline.Approved
MebicarPerampanel may increase the central nervous system depressant (CNS depressant) activities of Mebicar.Experimental
MeclizinePerampanel may increase the central nervous system depressant (CNS depressant) activities of Meclizine.Approved
MedazepamPerampanel may increase the central nervous system depressant (CNS depressant) activities of Medazepam.Experimental
MedetomidinePerampanel may increase the central nervous system depressant (CNS depressant) activities of Medetomidine.Vet Approved
Medroxyprogesterone acetateThe serum concentration of Medroxyprogesterone acetate can be decreased when it is combined with Perampanel.Approved, Investigational
MefloquineThe therapeutic efficacy of Perampanel can be decreased when used in combination with Mefloquine.Approved
MelatoninPerampanel may increase the central nervous system depressant (CNS depressant) activities of Melatonin.Approved, Nutraceutical, Vet Approved
MelperonePerampanel may increase the central nervous system depressant (CNS depressant) activities of Melperone.Approved, Investigational
MepivacainePerampanel may increase the central nervous system depressant (CNS depressant) activities of Mepivacaine.Approved, Vet Approved
MeprobamatePerampanel may increase the central nervous system depressant (CNS depressant) activities of Meprobamate.Approved, Illicit
MeptazinolPerampanel may increase the central nervous system depressant (CNS depressant) activities of Meptazinol.Experimental
MesoridazinePerampanel may increase the central nervous system depressant (CNS depressant) activities of Mesoridazine.Approved, Investigational
MetaxalonePerampanel may increase the central nervous system depressant (CNS depressant) activities of Metaxalone.Approved
MethadonePerampanel may increase the central nervous system depressant (CNS depressant) activities of Methadone.Approved
Methadyl AcetatePerampanel may increase the central nervous system depressant (CNS depressant) activities of Methadyl Acetate.Approved, Illicit
MethapyrilenePerampanel may increase the central nervous system depressant (CNS depressant) activities of Methapyrilene.Withdrawn
MethaqualonePerampanel may increase the central nervous system depressant (CNS depressant) activities of Methaqualone.Illicit, Withdrawn
MethocarbamolPerampanel may increase the central nervous system depressant (CNS depressant) activities of Methocarbamol.Approved, Vet Approved
MethohexitalPerampanel may increase the central nervous system depressant (CNS depressant) activities of Methohexital.Approved
MethotrimeprazinePerampanel may increase the central nervous system depressant (CNS depressant) activities of Methotrimeprazine.Approved
MethoxyfluranePerampanel may increase the central nervous system depressant (CNS depressant) activities of Methoxyflurane.Approved, Investigational, Vet Approved
MethsuximidePerampanel may increase the central nervous system depressant (CNS depressant) activities of Methsuximide.Approved
MethylecgoninePerampanel may increase the central nervous system depressant (CNS depressant) activities of Methylecgonine.Experimental
MethylphenobarbitalPerampanel may increase the central nervous system depressant (CNS depressant) activities of Methylphenobarbital.Approved
MetyrosinePerampanel may increase the sedative activities of Metyrosine.Approved
MianserinThe therapeutic efficacy of Perampanel can be decreased when used in combination with Mianserin.Approved, Investigational
MidazolamPerampanel may increase the central nervous system depressant (CNS depressant) activities of Midazolam.Approved, Illicit
MifepristoneThe serum concentration of Perampanel can be increased when it is combined with Mifepristone.Approved, Investigational
MilnacipranThe risk or severity of adverse effects can be increased when Perampanel is combined with Milnacipran.Approved
MinocyclineMinocycline may increase the central nervous system depressant (CNS depressant) activities of Perampanel.Approved, Investigational
MirtazapinePerampanel may increase the central nervous system depressant (CNS depressant) activities of Mirtazapine.Approved
MolindonePerampanel may increase the central nervous system depressant (CNS depressant) activities of Molindone.Approved
MorphinePerampanel may increase the central nervous system depressant (CNS depressant) activities of Morphine.Approved, Investigational
NabilonePerampanel may increase the central nervous system depressant (CNS depressant) activities of Nabilone.Approved, Investigational
NalbuphinePerampanel may increase the central nervous system depressant (CNS depressant) activities of Nalbuphine.Approved
NefazodoneThe metabolism of Perampanel can be decreased when combined with Nefazodone.Approved, Withdrawn
NelfinavirThe metabolism of Perampanel can be decreased when combined with Nelfinavir.Approved
NetupitantThe serum concentration of Perampanel can be increased when it is combined with Netupitant.Approved
NevirapineThe serum concentration of Perampanel can be decreased when it is combined with Nevirapine.Approved
NilotinibThe metabolism of Perampanel can be decreased when combined with Nilotinib.Approved, Investigational
NitrazepamPerampanel may increase the central nervous system depressant (CNS depressant) activities of Nitrazepam.Approved
Nitrous oxidePerampanel may increase the central nervous system depressant (CNS depressant) activities of Nitrous oxide.Approved, Vet Approved
NorelgestrominThe serum concentration of Norelgestromin can be decreased when it is combined with Perampanel.Approved
NorfluranePerampanel may increase the central nervous system depressant (CNS depressant) activities of Norflurane.Investigational
NorgestimateThe serum concentration of Norgestimate can be decreased when it is combined with Perampanel.Approved
NorgestrelThe serum concentration of Norgestrel can be decreased when it is combined with Perampanel.Approved
NormethadonePerampanel may increase the central nervous system depressant (CNS depressant) activities of Normethadone.Approved, Illicit
NortriptylinePerampanel may increase the central nervous system depressant (CNS depressant) activities of Nortriptyline.Approved
OlanzapinePerampanel may increase the central nervous system depressant (CNS depressant) activities of Olanzapine.Approved, Investigational
OlaparibThe metabolism of Perampanel can be decreased when combined with Olaparib.Approved
OlopatadinePerampanel may increase the central nervous system depressant (CNS depressant) activities of Olopatadine.Approved
OndansetronPerampanel may increase the central nervous system depressant (CNS depressant) activities of Ondansetron.Approved
OpiumPerampanel may increase the central nervous system depressant (CNS depressant) activities of Opium.Approved, Illicit
OrlistatThe serum concentration of Perampanel can be decreased when it is combined with Orlistat.Approved, Investigational
OsanetantPerampanel may increase the central nervous system depressant (CNS depressant) activities of Osanetant.Investigational
OsimertinibThe serum concentration of Perampanel can be increased when it is combined with Osimertinib.Approved
OxazepamPerampanel may increase the central nervous system depressant (CNS depressant) activities of Oxazepam.Approved
OxcarbazepineThe serum concentration of Oxcarbazepine can be increased when it is combined with Perampanel.Approved
OxethazainePerampanel may increase the central nervous system depressant (CNS depressant) activities of Oxethazaine.Approved, Investigational
OxprenololPerampanel may increase the central nervous system depressant (CNS depressant) activities of Oxprenolol.Approved
OxybuprocainePerampanel may increase the central nervous system depressant (CNS depressant) activities of Oxybuprocaine.Approved
OxycodonePerampanel may increase the central nervous system depressant (CNS depressant) activities of Oxycodone.Approved, Illicit, Investigational
OxymorphonePerampanel may increase the central nervous system depressant (CNS depressant) activities of Oxymorphone.Approved, Investigational, Vet Approved
PalbociclibThe serum concentration of Perampanel can be increased when it is combined with Palbociclib.Approved
PaliperidonePerampanel may increase the central nervous system depressant (CNS depressant) activities of Paliperidone.Approved
ParoxetineThe risk or severity of adverse effects can be increased when Perampanel is combined with Paroxetine.Approved, Investigational
PenfluridolPerampanel may increase the central nervous system depressant (CNS depressant) activities of Penfluridol.Experimental
PentazocinePerampanel may increase the central nervous system depressant (CNS depressant) activities of Pentazocine.Approved, Vet Approved
PentobarbitalPerampanel may increase the central nervous system depressant (CNS depressant) activities of Pentobarbital.Approved, Vet Approved
PerazinePerampanel may increase the central nervous system depressant (CNS depressant) activities of Perazine.Investigational
PerospironePerampanel may increase the central nervous system depressant (CNS depressant) activities of Perospirone.Approved
PerphenazinePerampanel may increase the central nervous system depressant (CNS depressant) activities of Perphenazine.Approved
PethidinePerampanel may increase the central nervous system depressant (CNS depressant) activities of Pethidine.Approved
PhenazocinePerampanel may increase the central nervous system depressant (CNS depressant) activities of Phenazocine.Experimental
PhenibutPerampanel may increase the central nervous system depressant (CNS depressant) activities of Phenibut.Experimental
PhenobarbitalPerampanel may increase the central nervous system depressant (CNS depressant) activities of Phenobarbital.Approved
PhenoperidinePerampanel may increase the central nervous system depressant (CNS depressant) activities of Phenoperidine.Experimental
PhenoxyethanolPerampanel may increase the central nervous system depressant (CNS depressant) activities of Phenoxyethanol.Approved
PhenytoinThe serum concentration of Perampanel can be decreased when it is combined with Phenytoin.Approved, Vet Approved
PimozidePerampanel may increase the central nervous system depressant (CNS depressant) activities of Pimozide.Approved
PipamperonePerampanel may increase the central nervous system depressant (CNS depressant) activities of Pipamperone.Approved, Investigational
PipotiazinePerampanel may increase the central nervous system depressant (CNS depressant) activities of Pipotiazine.Approved, Investigational
PiritramidePerampanel may increase the central nervous system depressant (CNS depressant) activities of Piritramide.Investigational
PizotifenPerampanel may increase the central nervous system depressant (CNS depressant) activities of Pizotifen.Approved
PomalidomidePerampanel may increase the central nervous system depressant (CNS depressant) activities of Pomalidomide.Approved
PosaconazoleThe metabolism of Perampanel can be decreased when combined with Posaconazole.Approved, Investigational, Vet Approved
PramipexolePerampanel may increase the sedative activities of Pramipexole.Approved, Investigational
PramocainePerampanel may increase the central nervous system depressant (CNS depressant) activities of Pramocaine.Approved
PrazepamPerampanel may increase the central nervous system depressant (CNS depressant) activities of Prazepam.Approved, Illicit
PregabalinPerampanel may increase the central nervous system depressant (CNS depressant) activities of Pregabalin.Approved, Illicit, Investigational
PrilocainePerampanel may increase the central nervous system depressant (CNS depressant) activities of Prilocaine.Approved
PrimidonePerampanel may increase the central nervous system depressant (CNS depressant) activities of Primidone.Approved, Vet Approved
ProcainePerampanel may increase the central nervous system depressant (CNS depressant) activities of Procaine.Approved, Investigational, Vet Approved
ProchlorperazinePerampanel may increase the central nervous system depressant (CNS depressant) activities of Prochlorperazine.Approved, Vet Approved
PromazinePerampanel may increase the central nervous system depressant (CNS depressant) activities of Promazine.Approved, Vet Approved
PromethazinePerampanel may increase the central nervous system depressant (CNS depressant) activities of Promethazine.Approved
PropanididPerampanel may increase the central nervous system depressant (CNS depressant) activities of Propanidid.Experimental
ProparacainePerampanel may increase the central nervous system depressant (CNS depressant) activities of Proparacaine.Approved, Vet Approved
PropofolPerampanel may increase the central nervous system depressant (CNS depressant) activities of Propofol.Approved, Investigational, Vet Approved
PropoxycainePerampanel may increase the central nervous system depressant (CNS depressant) activities of Propoxycaine.Approved
ProtriptylinePerampanel may increase the central nervous system depressant (CNS depressant) activities of Protriptyline.Approved
ProxibarbalPerampanel may increase the central nervous system depressant (CNS depressant) activities of Proxibarbal.Experimental
PSD502Perampanel may increase the central nervous system depressant (CNS depressant) activities of PSD502.Investigational
QuazepamPerampanel may increase the central nervous system depressant (CNS depressant) activities of Quazepam.Approved, Illicit
QuetiapinePerampanel may increase the central nervous system depressant (CNS depressant) activities of Quetiapine.Approved
QuinisocainePerampanel may increase the central nervous system depressant (CNS depressant) activities of Quinisocaine.Experimental
RaclopridePerampanel may increase the central nervous system depressant (CNS depressant) activities of Raclopride.Investigational
RamelteonPerampanel may increase the central nervous system depressant (CNS depressant) activities of Ramelteon.Approved, Investigational
RanolazineThe metabolism of Perampanel can be decreased when combined with Ranolazine.Approved, Investigational
RemifentanilPerampanel may increase the central nervous system depressant (CNS depressant) activities of Remifentanil.Approved
RemoxipridePerampanel may increase the central nervous system depressant (CNS depressant) activities of Remoxipride.Approved, Withdrawn
ReserpinePerampanel may increase the central nervous system depressant (CNS depressant) activities of Reserpine.Approved, Investigational
RifabutinThe serum concentration of Perampanel can be decreased when it is combined with Rifabutin.Approved
RifampicinThe serum concentration of Perampanel can be decreased when it is combined with Rifampicin.Approved
RifapentineThe serum concentration of Perampanel can be decreased when it is combined with Rifapentine.Approved
RisperidonePerampanel may increase the central nervous system depressant (CNS depressant) activities of Risperidone.Approved, Investigational
RitanserinPerampanel may increase the central nervous system depressant (CNS depressant) activities of Ritanserin.Investigational
RitonavirThe metabolism of Perampanel can be decreased when combined with Ritonavir.Approved, Investigational
RomifidinePerampanel may increase the central nervous system depressant (CNS depressant) activities of Romifidine.Vet Approved
RopinirolePerampanel may increase the sedative activities of Ropinirole.Approved, Investigational
RopivacainePerampanel may increase the central nervous system depressant (CNS depressant) activities of Ropivacaine.Approved
RotigotinePerampanel may increase the sedative activities of Rotigotine.Approved
RufinamideThe risk or severity of adverse effects can be increased when Rufinamide is combined with Perampanel.Approved
SaquinavirThe metabolism of Perampanel can be decreased when combined with Saquinavir.Approved, Investigational
SaxagliptinThe serum concentration of Saxagliptin can be decreased when it is combined with Perampanel.Approved
ScopolaminePerampanel may increase the central nervous system depressant (CNS depressant) activities of Scopolamine.Approved
SecobarbitalPerampanel may increase the central nervous system depressant (CNS depressant) activities of Secobarbital.Approved, Vet Approved
SepranolonePerampanel may increase the central nervous system depressant (CNS depressant) activities of Sepranolone.Investigational
SertindolePerampanel may increase the central nervous system depressant (CNS depressant) activities of Sertindole.Approved, Investigational, Withdrawn
SertralineThe risk or severity of adverse effects can be increased when Perampanel is combined with Sertraline.Approved
SevofluranePerampanel may increase the central nervous system depressant (CNS depressant) activities of Sevoflurane.Approved, Vet Approved
SildenafilThe metabolism of Perampanel can be decreased when combined with Sildenafil.Approved, Investigational
SiltuximabThe serum concentration of Perampanel can be decreased when it is combined with Siltuximab.Approved
SimeprevirThe serum concentration of Perampanel can be increased when it is combined with Simeprevir.Approved
Sodium oxybatePerampanel may increase the central nervous system depressant (CNS depressant) activities of Sodium oxybate.Approved
St. John's WortThe serum concentration of Perampanel can be decreased when it is combined with St. John's Wort.Investigational, Nutraceutical
StiripentolPerampanel may increase the central nervous system depressant (CNS depressant) activities of Stiripentol.Approved
SufentanilPerampanel may increase the central nervous system depressant (CNS depressant) activities of Sufentanil.Approved, Investigational
SulfisoxazoleThe metabolism of Perampanel can be decreased when combined with Sulfisoxazole.Approved, Vet Approved
SulpiridePerampanel may increase the central nervous system depressant (CNS depressant) activities of Sulpiride.Approved, Investigational
SultopridePerampanel may increase the central nervous system depressant (CNS depressant) activities of Sultopride.Experimental
SuvorexantPerampanel may increase the central nervous system depressant (CNS depressant) activities of Suvorexant.Approved
TandospironePerampanel may increase the central nervous system depressant (CNS depressant) activities of Tandospirone.Investigational
TapentadolPerampanel may increase the central nervous system depressant (CNS depressant) activities of Tapentadol.Approved
TasimelteonPerampanel may increase the central nervous system depressant (CNS depressant) activities of Tasimelteon.Approved
TelaprevirThe metabolism of Perampanel can be decreased when combined with Telaprevir.Approved, Withdrawn
TelithromycinThe metabolism of Perampanel can be decreased when combined with Telithromycin.Approved
TemazepamPerampanel may increase the central nervous system depressant (CNS depressant) activities of Temazepam.Approved
TetrabenazinePerampanel may increase the central nervous system depressant (CNS depressant) activities of Tetrabenazine.Approved
TetracainePerampanel may increase the central nervous system depressant (CNS depressant) activities of Tetracaine.Approved, Vet Approved
TetrahydropalmatinePerampanel may increase the central nervous system depressant (CNS depressant) activities of Tetrahydropalmatine.Investigational
TetrodotoxinPerampanel may increase the central nervous system depressant (CNS depressant) activities of Tetrodotoxin.Investigational
ThiamylalPerampanel may increase the central nervous system depressant (CNS depressant) activities of Thiamylal.Approved, Vet Approved
ThiopentalPerampanel may increase the central nervous system depressant (CNS depressant) activities of Thiopental.Approved, Vet Approved
ThioridazinePerampanel may increase the central nervous system depressant (CNS depressant) activities of Thioridazine.Approved, Withdrawn
ThiothixenePerampanel may increase the central nervous system depressant (CNS depressant) activities of Thiothixene.Approved
TiagabinePerampanel may increase the central nervous system depressant (CNS depressant) activities of Tiagabine.Approved
TiapridePerampanel may increase the central nervous system depressant (CNS depressant) activities of Tiapride.Approved, Investigational
TiclopidineThe metabolism of Perampanel can be decreased when combined with Ticlopidine.Approved
TiletaminePerampanel may increase the central nervous system depressant (CNS depressant) activities of Tiletamine.Vet Approved
TilidinePerampanel may increase the central nervous system depressant (CNS depressant) activities of Tilidine.Experimental
TizanidinePerampanel may increase the central nervous system depressant (CNS depressant) activities of Tizanidine.Approved
TocilizumabThe serum concentration of Perampanel can be decreased when it is combined with Tocilizumab.Approved
TolcaponePerampanel may increase the central nervous system depressant (CNS depressant) activities of Tolcapone.Approved, Withdrawn
TopiramatePerampanel may increase the central nervous system depressant (CNS depressant) activities of Topiramate.Approved
TramadolPerampanel may increase the central nervous system depressant (CNS depressant) activities of Tramadol.Approved, Investigational
Trans-2-PhenylcyclopropylaminePerampanel may increase the central nervous system depressant (CNS depressant) activities of Trans-2-Phenylcyclopropylamine.Experimental
TranylcyprominePerampanel may increase the central nervous system depressant (CNS depressant) activities of Tranylcypromine.Approved
TrazodonePerampanel may increase the central nervous system depressant (CNS depressant) activities of Trazodone.Approved, Investigational
TriazolamPerampanel may increase the central nervous system depressant (CNS depressant) activities of Triazolam.Approved
Tricaine methanesulfonatePerampanel may increase the central nervous system depressant (CNS depressant) activities of Tricaine methanesulfonate.Vet Approved
TrichloroethylenePerampanel may increase the central nervous system depressant (CNS depressant) activities of Trichloroethylene.Experimental
TrifluoperazinePerampanel may increase the central nervous system depressant (CNS depressant) activities of Trifluoperazine.Approved
TrifluperidolPerampanel may increase the central nervous system depressant (CNS depressant) activities of Trifluperidol.Experimental
TriflupromazinePerampanel may increase the central nervous system depressant (CNS depressant) activities of Triflupromazine.Approved, Vet Approved
TrimipraminePerampanel may increase the central nervous system depressant (CNS depressant) activities of Trimipramine.Approved
TriprolidinePerampanel may increase the central nervous system depressant (CNS depressant) activities of Triprolidine.Approved
Valproic AcidPerampanel may increase the central nervous system depressant (CNS depressant) activities of Valproic Acid.Approved, Investigational
VenlafaxineThe metabolism of Perampanel can be decreased when combined with Venlafaxine.Approved
VeralipridePerampanel may increase the central nervous system depressant (CNS depressant) activities of Veralipride.Experimental
VerapamilThe metabolism of Perampanel can be decreased when combined with Verapamil.Approved
VigabatrinPerampanel may increase the central nervous system depressant (CNS depressant) activities of Vigabatrin.Approved
Vinyl etherPerampanel may increase the central nervous system depressant (CNS depressant) activities of Vinyl ether.Experimental
VoriconazoleThe metabolism of Perampanel can be decreased when combined with Voriconazole.Approved, Investigational
VortioxetinePerampanel may increase the central nervous system depressant (CNS depressant) activities of Vortioxetine.Approved
XenonPerampanel may increase the central nervous system depressant (CNS depressant) activities of Xenon.Experimental
XylazinePerampanel may increase the central nervous system depressant (CNS depressant) activities of Xylazine.Vet Approved
ZaleplonPerampanel may increase the central nervous system depressant (CNS depressant) activities of Zaleplon.Approved, Illicit, Investigational
ZiconotidePerampanel may increase the central nervous system depressant (CNS depressant) activities of Ziconotide.Approved
ZimelidineThe risk or severity of adverse effects can be increased when Perampanel is combined with Zimelidine.Withdrawn
ZiprasidonePerampanel may increase the central nervous system depressant (CNS depressant) activities of Ziprasidone.Approved
ZolazepamPerampanel may increase the central nervous system depressant (CNS depressant) activities of Zolazepam.Vet Approved
ZolpidemPerampanel may increase the central nervous system depressant (CNS depressant) activities of Zolpidem.Approved
ZonisamidePerampanel may increase the central nervous system depressant (CNS depressant) activities of Zonisamide.Approved, Investigational
ZopiclonePerampanel may increase the central nervous system depressant (CNS depressant) activities of Zopiclone.Approved
ZotepinePerampanel may increase the central nervous system depressant (CNS depressant) activities of Zotepine.Approved, Investigational
ZuclopenthixolPerampanel may increase the central nervous system depressant (CNS depressant) activities of Zuclopenthixol.Approved, Investigational
Food Interactions
  • Food slows perampanel's absorption rate but not extent.

References

Synthesis Reference

Francesco Fontana, "METHODS FOR PREPARING INTERMEDIATES OF PERAMPANEL." U.S. Patent US20130109862, issued May 02, 2013.

US20130109862
General References
  1. Hanada T, Hashizume Y, Tokuhara N, Takenaka O, Kohmura N, Ogasawara A, Hatakeyama S, Ohgoh M, Ueno M, Nishizawa Y: Perampanel: a novel, orally active, noncompetitive AMPA-receptor antagonist that reduces seizure activity in rodent models of epilepsy. Epilepsia. 2011 Jul;52(7):1331-40. doi: 10.1111/j.1528-1167.2011.03109.x. Epub 2011 Jun 2. [PubMed:21635236]
External Links
KEGG Drug
D08964
PubChem Compound
9924495
PubChem Substance
347827808
ChemSpider
8100130
ChEBI
71013
ChEMBL
CHEMBL1214124
HET
6ZP
RxList
RxList Drug Page
Drugs.com
Drugs.com Drug Page
Wikipedia
Perampanel
ATC Codes
N03AX22 — Perampanel
AHFS Codes
  • 28:12.92 — Miscellaneous Anticonvulsants
PDB Entries
5l1f
FDA label
Download (611 KB)

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount
1CompletedTreatmentCentral Nervous System1
1CompletedTreatmentHealthy Volunteers5
1CompletedTreatmentPartial Onset Epilepsy2
1, 2RecruitingTreatmentCervical Dystonia1
2Active Not RecruitingTreatmentSmall Fibre Neuropathy1
2Active Not RecruitingTreatmentTremor, Essential1
2CompletedNot AvailableParkinson's Disease (PD)1
2CompletedTreatmentCentral Nervous System1
2CompletedTreatmentEpilepsies3
2CompletedTreatmentParkinson's Disease (PD)1
2CompletedTreatmentRefractory Partial Seizures2
2CompletedTreatmentNeurocostal neuralgia1
2CompletedTreatmentProphylaxis of migraine headaches1
2Not Yet RecruitingTreatmentAmyotrophic Lateral Sclerosis (ALS)1
2RecruitingTreatmentEpilepsies1
2SuspendedTreatmentAlcoholism1
2TerminatedTreatmentParkinson's Disease (PD)3
2Unknown StatusTreatmentEpilepsies1
2WithdrawnTreatmentParkinson's Disease (PD)1
2, 3CompletedTreatmentDiabetic Neuropathies1
2, 3CompletedTreatmentNeurocostal neuralgia1
3Active Not RecruitingTreatmentPartial onset seizure Epilepsy1
3CompletedTreatmentEpilepsies2
3CompletedTreatmentParkinson's Disease (PD)2
3CompletedTreatmentRefractory Partial Seizures3
3CompletedTreatmentSeizure Disorder Generalized Tonic Clonic1
3RecruitingTreatmentLennox-Gastaut Syndrome (LGS)1
3RecruitingTreatmentPartial-Onset or Primary Generalized Tonic-Clonic Seizures1
3RecruitingTreatmentPartial onset seizure Epilepsy1
3TerminatedTreatmentParkinson's Disease (PD)3
4Active Not RecruitingTreatmentEpilepsies1
4CompletedTreatmentBrain Tumor, Primary1
4RecruitingNot AvailableElectroencephalography1
4RecruitingTreatmentPartial onset seizure Epilepsy / Primary Generalized tonic-clonic seizure / Secondarily Generalized Seizures1
4TerminatedTreatmentEpilepsies1
4WithdrawnTreatmentEpilepsy, Localization Related1
Not AvailableAvailableNot AvailableSeizure Disorder Generalized Tonic Clonic1
Not AvailableAvailableNot AvailablePartial onset seizure Epilepsy1
Not AvailableCompletedNot AvailableRefractory Epilepsy1
Not AvailableNot Yet RecruitingNot AvailableEpilepsies1
Not AvailableRecruitingNot AvailableEpilepsies1
Not AvailableRecruitingNot AvailablePartial Seizures (With or Without Secondary Generalized Seizures) / Primary Generalized tonic-clonic seizure2
Not AvailableRecruitingTreatmentAmyotrophic Lateral Sclerosis (ALS)1

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage forms
FormRouteStrength
Kit
SuspensionOral.5 mg/mL
SuspensionOral0.5 mg
TabletOral10 mg/1
TabletOral10.0 mg
TabletOral12 mg/1
TabletOral12.0 mg
TabletOral2 mg/1
TabletOral2.0 mg
TabletOral4 mg/1
TabletOral4.0 mg
TabletOral6 mg/1
TabletOral6.0 mg
TabletOral8 mg/1
TabletOral8.0 mg
Tablet, film coatedOral10 mg
Tablet, film coatedOral12 mg
Tablet, film coatedOral2 mg
Tablet, film coatedOral4 mg
Tablet, film coatedOral6 mg
Tablet, film coatedOral8 mg
Prices
Not Available
Patents
Patent NumberPediatric ExtensionApprovedExpires (estimated)
US6949571No2001-06-082021-06-08Us
US8772497No2006-05-162026-05-16Us

Properties

State
Solid
Experimental Properties
PropertyValueSource
water solubilityPractically insoluble in water.From FDA label.
Predicted Properties
PropertyValueSource
Water Solubility0.0056 mg/mLALOGPS
logP3.54ALOGPS
logP4.11ChemAxon
logS-4.8ALOGPS
pKa (Strongest Basic)4.01ChemAxon
Physiological Charge0ChemAxon
Hydrogen Acceptor Count3ChemAxon
Hydrogen Donor Count0ChemAxon
Polar Surface Area56.99 Å2ChemAxon
Rotatable Bond Count3ChemAxon
Refractivity104.74 m3·mol-1ChemAxon
Polarizability38.03 Å3ChemAxon
Number of Rings4ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleNoChemAxon
MDDR-like RuleNoChemAxon
Predicted ADMET features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
SpectrumSpectrum TypeSplash Key
Predicted MS/MS Spectrum - 10V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 20V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 40V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 10V, Negative (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 20V, Negative (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 40V, Negative (Annotated)Predicted LC-MS/MSNot Available

Taxonomy

Description
This compound belongs to the class of organic compounds known as bipyridines and oligopyridines. These are organic compounds containing two pyridine rings linked to each other.
Kingdom
Organic compounds
Super Class
Organoheterocyclic compounds
Class
Pyridines and derivatives
Sub Class
Bipyridines and oligopyridines
Direct Parent
Bipyridines and oligopyridines
Alternative Parents
Phenylpyridines / Benzonitriles / Pyridinones / Dihydropyridines / Heteroaromatic compounds / Lactams / Nitriles / Azacyclic compounds / Organopnictogen compounds / Organooxygen compounds
show 2 more
Substituents
Bipyridine / 3-phenylpyridine / Benzonitrile / Dihydropyridine / Pyridinone / Monocyclic benzene moiety / Hydropyridine / Benzenoid / Heteroaromatic compound / Lactam
show 11 more
Molecular Framework
Aromatic heteromonocyclic compounds
External Descriptors
nitrile, pyridone, bipyridines (CHEBI:71013)

Targets

Kind
Protein
Organism
Human
Pharmacological action
Yes
Actions
Antagonist
General Function
Pdz domain binding
Specific Function
Ionotropic glutamate receptor. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a co...
Gene Name
GRIA1
Uniprot ID
P42261
Uniprot Name
Glutamate receptor 1
Molecular Weight
101505.245 Da
References
  1. Hanada T, Hashizume Y, Tokuhara N, Takenaka O, Kohmura N, Ogasawara A, Hatakeyama S, Ohgoh M, Ueno M, Nishizawa Y: Perampanel: a novel, orally active, noncompetitive AMPA-receptor antagonist that reduces seizure activity in rodent models of epilepsy. Epilepsia. 2011 Jul;52(7):1331-40. doi: 10.1111/j.1528-1167.2011.03109.x. Epub 2011 Jun 2. [PubMed:21635236]

Enzymes

Kind
Protein
Organism
Human
Pharmacological action
No
Actions
Substrate
Inducer
General Function
Vitamin d3 25-hydroxylase activity
Specific Function
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It performs a variety of oxidation react...
Gene Name
CYP3A4
Uniprot ID
P08684
Uniprot Name
Cytochrome P450 3A4
Molecular Weight
57342.67 Da
Kind
Protein
Organism
Human
Pharmacological action
No
Actions
Substrate
General Function
Oxygen binding
Specific Function
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally un...
Gene Name
CYP3A5
Uniprot ID
P20815
Uniprot Name
Cytochrome P450 3A5
Molecular Weight
57108.065 Da

Drug created on May 21, 2013 19:44 / Updated on November 14, 2017 08:12