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Displaying drugs 26 - 50 of 192 in total
Lovastatin, also known as the brand name product Mevacor, is a lipid-lowering drug and fungal metabolite derived synthetically from a fermentation product of Aspergillus terreus. Originally named Mevinolin, lovastatin belongs to the statin class of medications, which are used to lower the risk of cardiovascular disease and manage abnormal lipid...
Approved
Investigational
Matched Synonyms: … 6-alpha-methylcompactin ... -2-yl)ethyl)-1-naphthalenyl (S)-2-methyl-butyrate ... 2β,6α-dimethyl-8alpha-(2-methyl-1-oxobutoxy)-mevinic acid lactone …
Matched Iupac: … -1-yl (2S)-2-methylbutanoate ... (1S,3R,7S,8S,8aR)-8-{2-[(2R,4R)-4-hydroxy-6-oxooxan-2-yl]ethyl}-3,7-dimethyl-1,2,3,7,8,8a-hexahydronaphthalen …
Matched Description: … coronary death) for every 1 mmol/L reduction in LDL without any significant side effects or risks. ... for people with a moderate to high risk of development of CVD, such as those with Type 2 Diabetes. ... [rosuvastatin] which are taken up into hepatocytes through OATP1B1 (organic anion transporter protein
Matched Categories: … lovastatin and nicotinic acid …
Rosuvastatin, also known as the brand name product Crestor, is a lipid-lowering drug that belongs to the statin class of medications, which are used to lower the risk of cardiovascular disease and manage elevated lipid levels by inhibiting the endogenous production of cholesterol in the liver. More specifically, statin medications...
Approved
Matched Synonyms: … (3R,5S,6E)-7-(4-(4-fluorophenyl)-6-(1-methylethyl)-2-(ethyl(methylsulfonyl)amino)-5-pyrimidinyl)-3,5- ... -6-enoic acid ... dihydroxy-6-heptenoic acid …
Matched Iupac: … -6-enoic acid ... (3R,5S,6E)-7-[4-(4-fluorophenyl)-2-(N-methylmethanesulfonamido)-6-(propan-2-yl)pyrimidin-5-yl]-3,5-dihydroxyhept …
Matched Description: … coronary death) for every 1 mmol/L reduction in LDL without any significant side effects or risks. ... for people with a moderate to high risk of development of CVD, such as those with Type 2 Diabetes. ... with this statin through antagonism of OATP1B1 organic anion transporter protein 1B1-mediated hepatic …
Matched Mixtures name: … Rosuvastatin and Ezetimibe ... Rosuvastatin and Ezetimibe ... Rosuvastatin and Ezetimibe …
Matched Categories: … Heterocyclic Compounds, 1-Ring ... Alimentary Tract and Metabolism ... rosuvastatin and ramipril ... rosuvastatin and valsartan ... rosuvastatin and ezetimibe …
Matched Products: … ROSUVASTATIN 1 A 5MG ... ROSUVASTATIN 1 A 10MG ... ROSUVASTATIN 1 A 20MG …
Abatacept is a soluble fusion protein, which links the extracellular domain of human cytotoxic T-lymphocyte-associated antigen 4 (CTLA-4) to the modified Fc (hinge, CH2, and CH3 domains) portion of human immunoglobulin G1 (IgG1).[L20504,L42715] Structurally, abatacept is a glycosylated fusion protein with a MALDI-MS molecular weight of 92,300 Da and it...
Approved
Matched Description: … antigen 4 (CTLA-4) to the modified Fc (hinge, CH2, and CH3 domains) portion of human immunoglobulin ... Abatacept is a soluble fusion protein, which links the extracellular domain of human cytotoxic T-lymphocyte-associated ... of 92,300 Da and it is a homodimer of two homologous polypeptide chains of 357 amino acids each. …
Matched Categories: … Amino Acids, Peptides, and Proteins ... Antineoplastic and Immunomodulating Agents …
Talimogene laherparepvec is an oncolytic treatment used in local treatment of unresectable cutaneous, subcutaneous, and nodal lesions in patients with recurrent melanoma. It is a genetically administered herpes simplex virus 1 (HSV-1) that expresses human cytokine granulocyte-macrophage colony stimulating factor (GM-CSF) with antitumor and immune-stimulating activities. It specifically replicates within...
Approved
Experimental
Investigational
Matched Description: … It is a genetically administered herpes simplex virus 1 (HSV-1) that expresses human cytokine granulocyte-macrophage ... It specifically replicates within tumor cells and causes lysis. ... colony stimulating factor (GM-CSF) with antitumor and immune-stimulating activities. …
Matched Categories: … Antineoplastic cell and gene therapy ... Antineoplastic and Immunomodulating Agents …
Humanized IgG1 kappa isotype monoclonal antibody that binds to human CD11a. Efalizumab has a molecular weight of approximately 150 kilodaltons and is produced in a Chinese hamster ovary mammalian cell expression system in a nutrient medium containing the antibiotic gentamicin. The FDA approved efalizumab in 2003. It was later withdrawn...
Approved
Investigational
Withdrawn
Matched Description: … Humanized IgG1 kappa isotype monoclonal antibody that binds to human CD11a. ... Efalizumab has a molecular weight of approximately 150 kilodaltons and is produced in a Chinese hamster …
Matched Categories: … Amino Acids, Peptides, and Proteins ... Antineoplastic and Immunomodulating Agents …
Histrelin is a gonadotropin-releasing hormone (GnRH) agonist that acts as a potent inhibitor of gonadotropin when administered as an implant delivering continuous therapeutic doses. This drug is a synthetic analog of naturally occurring GnRH with a higher potency. Histrelin implants are non-biodegradable, diffusion-controlled, hydrogel polymer reservoirs containing histrelin acetate that...
Approved
Withdrawn
Matched Synonyms: … 5-oxo-L-prolyl-L-histidyl-L-tryptophyl-L-seryl-L-tyrosyl-1-benzyl-D-histidyl-L-leucyl-L-arginyl-N-ethyl-L-prolinamide ... 5-oxo-L-prolyl-L-histidyl-L-tryptophyl-L-seryl-L-tyrosyl-Nτ-benzyl-D-histidyl-L-leucyl-L-arginyl-N-ethyl-L-prolinamide ... L-pyroglutamyl-L-histidyl-L-tryptophyl-L-seryl-L-tyrosyl-D-Nim-benzyl-histidyl-L-leucyl-L-arginyl-L-proline …
Matched Iupac: … (2S)-1-[(2S)-2-[(2S)-2-[(2R)-3-(1-benzyl-1H-imidazol-4-yl)-2-[(2S)-2-[(2S)-3-hydroxy-2-[(2S)-2-[(2S)- …
Matched Description: … treatment for children with central precocious puberty (CPP) due to their capacity to reduce LH levels and
Matched Categories: … Hormones and Related Agents ... Amino Acids, Peptides, and Proteins ... Antineoplastic and Immunomodulating Agents ... Hormones, Hormone Substitutes, and Hormone Antagonists …
Hepatitis D is considered the most severe type of viral hepatitis and leads to the rapid development of cirrhosis, severe decompensation of liver function, and an increased risk of mortality.[A226340,L30235] Until recently, there have been extremely limited treatments available for Hepatitis D infection. Bulevirtide, also known as Hepcludex, is a...
Approved
Investigational
Matched Description: … Hepatitis D is considered the most severe type of viral hepatitis and leads to the rapid development ... of cirrhosis, severe decompensation of liver function, and an increased risk of mortality. ... first approved for use in the EU on May 28, 2020; bulevirtide has been granted PRIME scheme eligibility and
Matched Categories: … Amino Acids, Peptides, and Proteins …
Equine anti-thymocyte globulin is composed of purified gamma globulin containing primarily IgG against human thymus lymphocytes. It is formed by inoculating a horse with an antigen (human thymoyctes) which then induces the horse immune system's B-lymphocytes to produce IgG immunoglobulins specific for that antigen. The result is polyclonal IgG that...
Approved
Investigational
Matched Description: … in the type of antigen product used to produce immunoglobulin (thymocytes, peripheral T cells, etc.) ... It is formed by inoculating a horse with an antigen (human thymoyctes) which then induces the horse immune ... Equine anti-thymocyte globulin is composed of purified gamma globulin containing primarily IgG against human
Matched Categories: … Antibody-Surface Protein Interactions ... Fluids and Secretions ... Amino Acids, Peptides, and Proteins ... Antineoplastic and Immunomodulating Agents …
Approved
Vet approved
Matched Iupac: … 9a,11a-dimethyl-7-oxo-1H,2H,3H,3aH,3bH,4H,5H,7H,8H,9H,9aH,9bH,10H,11H,11aH-cyclopenta[a]phenanthren-1- …
Matched Mixtures name: … Lidotral 5 Percent and Hydrocortisone 1 Percent with Peptides and Arnica ... Iodoquinol 1% - Hydrocortisone Acetate 2% - Aloe Polysaccharides 1% ... HYDRODERM-C CREAM 1% …
Matched Categories: … 11-Hydroxycorticosteroids ... Hydrocortisone and derivatives ... Hormones, Hormone Substitutes, and Hormone Antagonists …
Matched Products: … American Safety and First Aid ... HC 1% CREAM ... Corticreme 1% …
Mifamurtide is an immunomodulator with antitumor activity via activation of macrophages and monocytes. Also called L-MTP-PE, mifamurtide may be a liposomal form of of the active ingredient MTP-PE, which is a synthetic, less pyrogenic, and longer-acting derivative of muramyl dipeptide (MDP). MDP is a motif present in all gram-positive and...
Approved
Experimental
Matched Iupac: … sodium (2R)-1-({2-[(2S)-2-[(4R)-4-carbamoyl-4-[(2S)-2-[(2R)-2-{[(2R,3R,4R,5R)-2-acetamido-4,5,6-trihydroxy ... -1-oxohexan-3-yl]oxy}propanamido]propanamido]butanamido]propanamido]ethyl phosphono}oxy)-3-(hexadecanoyloxy …
Matched Description: … Also called L-MTP-PE, mifamurtide may be a liposomal form of of the active ingredient MTP-PE, which is ... receptors (NLRs) and toll-like receptors present in macrophages and monocytes. ... signalling molecules and activators such as nucleotide-binding and oligomerization domain (NOD)-like …
Matched Categories: … Amino Acids, Peptides, and Proteins ... Antineoplastic and Immunomodulating Agents …
Matched Products: … MEPACT 4 MG INFÜZYONLUK DISPERSIYON KONSANTRESI IÇIN TOZ ,FLAKON, 1 ADET …
Metastatic triple-negative breast cancer (mTNBC) is an aggressive form of breast cancer with limited treatment options involving cytotoxic chemotherapy agents. Targeted chemotherapy through the application of antibody-conjugated agents (ADCs) is a recent advance in cancer treatment. One such ADC is sacituzumab govitecan, which combines a humanized anti-trophoblast cell-surface antigen 2...
Approved
Investigational
Matched Description: … A193671] One such ADC is sacituzumab govitecan, which combines a humanized anti-trophoblast cell-surface antigen ... Commission and Health Canada respectively. ... [L13002, A193674] Sacituzumab govitecan was granted FDA approval on April 22nd, 2020 and is marketed …
Matched Categories: … Amino Acids, Peptides, and Proteins ... Antineoplastic and Immunomodulating Agents ... MONOCLONAL ANTIBODIES AND ANTIBODY DRUG CONJUGATES …
Matched Products: … TRODELVY 200 MG İNFÜZYONLUK ÇÖZELTİ KONSANTRESİ İÇİN TOZ, 1 ADET …
Apalutamide is a potent androgen receptor (AR) antagonist that selectively binds to the ligand-binding domain of AR and blocks AR nuclear translocation or binding to androgen response elements . It has been used in trials studying the treatment of Prostate Cancer, Hepatic Impairment, Prostatic Neoplasms, Castration-Resistant Prostate Cancer, and Prostatic...
Approved
Investigational
Matched Iupac: … 4-{7-[6-cyano-5-(trifluoromethyl)pyridin-3-yl]-8-oxo-6-sulfanylidene-5,7-diazaspiro[3.4]octan-5-yl}-2 …
Matched Description: … Higher prostate-specific antigen (PSA) and shorter PSA doubling time (PSA DT) are associated with a higher ... Approximately 10 to 20 % of prostate cancer cases are castration-resistant, and up to 16% of these patients ... Unlike bicalutamide, apalutamide antagonized AR-mediated signaling in AR overexpressing human CRPC cell …
Matched Categories: … MATE 1 Inhibitors ... Heterocyclic Compounds, 1-Ring ... Antineoplastic and Immunomodulating Agents ... Hormone Antagonists and Related Agents …
Cold agglutinin disease (CAD) is a type of autoimmune hemolytic anemia (AIHA) in which autoantibodies directed against red blood cell surface antigens cause hemolysis at low (3-4°C) temperatures.[A245154,L40114] This cold subtype accounts for approximately 15-25% of all AIHA and is more common in the elderly.[A245159,L40114] In approximately 90% of cases,...
Approved
Investigational
Matched Synonyms: … Humanized IgG4 monoclonal antibody against total complement component 1, subcomponent s …
Matched Description: … Cold agglutinin disease (CAD) is a type of autoimmune hemolytic anemia (AIHA) in which autoantibodies ... In approximately 90% of cases, patients develop immunoglobulin M (IgM) autoantibodies towards the I antigen ... [A245154,L40114] This cold subtype accounts for approximately 15-25% of all AIHA and is more common in …
Matched Categories: … Amino Acids, Peptides, and Proteins ... Antineoplastic and Immunomodulating Agents …
Approved
Investigational
Matched Name: … Human papillomavirus type 18 L1 capsid protein residues 2-472 antigen
Antihemophilic factor human, also known as Coagulation Factor VIII or Anti-Hemophilic Factor (AHF), is a non-recombinant, lyophilized concentrate of coagulation factor VIII, an endogenous protein and essential component of the coagulation cascade. Antihemophilic factor is manufactured with reduced amounts of von Willebrand Factor antigen (VWF:Ag) and purified from extraneous plasma-derived...
Approved
Matched Synonyms: … F8 protein, human ... factor VIII, human ... Factor VIII (human) …
Matched Name: … Antihemophilic factor human
Matched Description: … Unfortunately, purification of protein from human plasma carries an increased risk of transmission of ... Antihemophilic factor is manufactured with reduced amounts of von Willebrand Factor antigen (VWF:Ag) ... and purified from extraneous plasma-derived protein by affinity chromatography. …
Matched Mixtures name: … Haemate P Powder and solvent for solution for injection or infusion ... BERIPLAST-P COMBI SET 1 ML TROMBİN ÇÖZELTİSİ VE 1 ML FİBRİNOJEN ÇÖZELTİSİ İÇEREN FİBRİN YAPIŞTIRICI ... Wilate 500, 500 IU VWF/500 IU FVIII, Powder and Solvent for Solution for Injection …
Matched Categories: … Protein Precursors ... Human Antihemophilic Factors ... Blood and Blood Forming Organs ... Amino Acids, Peptides, and Proteins …
Matched Products: … NUWIQ POWDER AND SOLVENT FOR SOLUTION FOR INJECTION 500 IU ... NUWIQ POWDER AND SOLVENT FOR SOLUTION FOR INJECTION 250 IU ... NUWIQ POWDER AND SOLVENT FOR SOLUTION FOR INJECTION 1000 IU …
Human adenovirus e serotype 4 strain cl-68578 antigen is a vaccine.
Approved
Matched Synonyms: … Mastadenovirus Human Adenovirus B Type 4 Strain Cl-68578 ... Adenovirus Type 4 Vaccine Live ... Adenovirus Type 4 Strain Cl-68578 …
Matched Name: … Human adenovirus e serotype 4 strain cl-68578 antigen
Matched Description: … Human adenovirus e serotype 4 strain cl-68578 antigen is a vaccine. …
Matched Mixtures name: … Adenovirus Type 4 and Type 7 Vaccine, Live …
Matched Categories: … Live Human Adenovirus Type 4 Vaccine …
Approved
Matched Synonyms: … Human adenovirus B serotype 7 strain 55142 antigen
Matched Name: … Adenovirus type 7 vaccine live …
Matched Mixtures name: … Adenovirus Type 4 and Type 7 Vaccine, Live …
Matched Categories: … Live Human Adenovirus Type 7 Vaccine …
Anthrax immune globulin is a human antibody given with antibiotics for the treatment of anthrax. It is derived from the plasma of humans immunized with BioThrax (adsorbed anthrax vaccine), which is then further purified. Available as the product Anthrasil (FDA), the result is a solution for slow IV infusion containing...
Approved
Matched Synonyms: … Anthrax immune globulin human ... Anthrax immune globulin (human) ... Anthrax immunoglobulin (human) …
Matched Name: … Anthrax immune globulin human
Matched Description: … Anthrax immune globulin is a human antibody given with antibiotics for the treatment of anthrax. ... result is a solution for slow IV infusion containing polyclonal antibodies that bind the protective antigen ... (PA) component of Bacillus anthracis lethal and edema toxins. …
Matched Categories: … Human Immunoglobulin ... Amino Acids, Peptides, and Proteins …
Tuberculin Purified Protein Derivative (PPD) is a sterile aqueous solution of a purified protein fraction for intradermal administration as an aid in the diagnosis of tuberculosis. The diagnostic test is commonly referred to as the Mantoux test which serves to minimize the risk of transmission of infection with Mycobacterium tuberculosis...
Approved
Matched Synonyms: … Tuberculin,purified protein derivative ... Tuberculin, purified protein derivative ... Purified protein derivative of tuberculin …
Matched Name: … Tuberculin purified protein derivative …
Matched Description: … The purified protein fraction is isolated from culture media filtrates of a human strain of Mycobacterium ... minimize the risk of transmission of infection with *Mycobacterium tuberculosis* through early diagnosis and ... Tuberculin Purified Protein Derivative (PPD) is a sterile aqueous solution of a purified protein fraction …
Matched Categories: … Skin Test Antigen ... Indicators and Reagents ... Amino Acids, Peptides, and Proteins …
Matched Products: … PPD TÜBERKÜLİN 100 TU/2 ML İNTRADERMAL ENJEKSİYONLUK ÇÖZELTİ, 1 ADET ... PPD TÜBERKÜLIN 5 TU/ 0.1 ML INTRADERMAL ENJEKSIYONLUK ÇÖZELTI IÇEREN FLAKON, 1 ADET …
Inactivated rabies virus antigen B is a component of rabies vaccines used for pre- and post-exposure prophylaxis against rabies.
Approved
Matched Synonyms: … Rabies virus vaccine wistar strain PM-1503-3M (human) ... Rabies virus strain PM-1503-3M antigen (propiolactone inactivated) …
Matched Name: … Rabies virus inactivated antigen, B …
Matched Description: … Inactivated rabies virus antigen B is a component of rabies vaccines used for pre- and post-exposure …
Matched Categories: … Immune Sera and Immunoglobulins …
Matched Products: … RABIES VACCINE FOR HUMAN USE (VERO CELL), FREEZE-DRIED FINAL BULK …
Human Rho(D) immune globulin is a medicine given by intramuscular or intravenous injection that is used to prevent the immunological condition known as Rh disease (or hemolytic disease of newborn). Rho (D) immune globulin is available as a sterile, lyophilized or liquid gamma globulin (IgG) fraction containing antibodies to the...
Approved
Investigational
Matched Synonyms: … Human anti-D immunoglobulin ... Immunoglobulin human anti-RH ... Rho D immune globulin human
Matched Name: … Human Rho(D) immune globulin …
Matched Description: … Immune globullin was purified via ion-exchange chromatography method and prepared from pools of human ... (D antigen) under the name Rhophylac (IM/IV). ... Human Rho(D) immune globulin is a medicine given by intramuscular or intravenous injection that is used …
Matched Categories: … Human Immunoglobulin G ... Endogenous Antigen Neutralization ... Amino Acids, Peptides, and Proteins ... Immune Sera and Immunoglobulins …
Matched Products: … WIN RHO SDF 300 MCG FLAKON, 1 ADET ... IMMUNORHO 300 MCG (1500 IU)/ 2 ML IM ENJEKSIYON ICIN LIYOFILIZE TOZ ICEREN FLAKON, 1 ADET …
Vibrio cholerae CVD 103-HgR strain live antigen is a component of Vaxchora, an oral vaccine for immunization against Vibrio cholerae serogroup O1. Cholera is an acute bacterial disease of the small intestine caused by Vibrio cholerae, which is gram-negative bacteria. Two serogroups of V. cholerae, O1 and O139, are causative...
Approved
Investigational
Matched Name: … Vibrio cholerae CVD 103-HgR strain live antigen
Matched Description: … _Vibrio cholerae_ CVD 103-HgR strain live antigen is a component of Vaxchora, an oral vaccine for immunization ... A244489] The FDA approved the cholera vaccine containing _Vibrio cholerae_ CVD 103-HgR strain live antigen ... [L39729] It is indicated for individuals aged two years and older.[L12801] …
Matched Products: … Cholera Vaccine Strain 35a-and 41 8000m/cc …
Human cord blood hematopoietic progenitor cells consist of hematopoietic progenitor cells, monocytes, lymphocytes, and granulocytes from human cord blood. They are used during allogeneic unrelated and related hematopoietic stem cell transplantation procedures in patients with disorders affecting the hematopoietic system that are inherited, acquired, or result from myeloablative treatment. Human...
Approved
Matched Name: … Human cord blood hematopoietic progenitor cell …
Matched Description: … marrow transplantation; it allows shorter time to transplant and tolerance of 1–2 human leukocyte antigen ... lymphocytes, and granulocytes from human cord blood. ... Human umbilical cord is a rich source of hematopoietic stem cells and progenitor cells that are capable …
Long-term hepatitis B immune globulin (HBIG) has been shown to reduce hepatitis B virus (HBV) reinfection in patients transplanted for hepatitis B. Infection with hepatitis B may lead to hepatocellular carcinoma, a type of liver cancer. Therefore, the hepatitis-B vaccines are cancer-preventing vaccines. According to the Centers for Disease Control...
Approved
Investigational
Matched Synonyms: … Hepatitis B immune globulin human ... Hepatitis B immune globulin (human) ... Human hepatitis B immunoglobulin …
Matched Description: … Infection with hepatitis B may lead to hepatocellular carcinoma, a type of liver cancer. ... HBIG is prepared from the plasma of donors who have high antibody levels of the hepatitis B surface antigen ... The preparation is tested for absence of HIV, HCV, herpes virus, and reovirus. …
Matched Categories: … Human Immunoglobulin ... Amino Acids, Peptides, and Proteins ... Immune Sera and Immunoglobulins …
Matched Products: … ICIN LIYOFILIZE TOZ ICEREN FLAKON, 1 ADET ... HEPAGAM B 312 IU/1 ML IM/IV ENJEKSİYONLUK/İNFÜZYONLUK ÇÖZELTİ ... HEPABULİN SN 2.000 IU/10 ML IV ENJEKSİYONLUK ÇÖZELTİ , 1 ADET …
Talquetamab is a IgG4-PAA bispecific G protein-coupled receptor class C group 5 member D (GPRC5D)-directed CD3 T-cell engager. It consists of two arms - anti-GPRC5D and anti-CD3 arms - linked by two interchain disulfide bonds, each arm comprising a heavy and light chain. Talquetamab binds to GPRC5D, a cell surface...
Approved
Investigational
Matched Synonyms: … IMMUNOGLOBULIN G4 (233-PROLINE,239-ALANINE,240-ALANINE,410-LEUCINE,414-LYSINE), ANTI-(HUMAN CD3 ANTIGEN ... ) (HUMAN MONOCLONAL JNJ-63483043 .GAMMA.4-CHAIN), DISULFIDE WITH HUMAN MONOCLONAL JNJ-63483043 .LAMBDA ... IMMUNOGLOBULIN G4-KAPPA/G4-LAMBDA, ANTI-(HOMO SAPIENS GPRC5D (G PROTEIN-COUPLED RECEPTOR CLASS C GROUP …
Matched Description: … Talquetamab is a IgG4-PAA bispecific G protein-coupled receptor class C group 5 member D (GPRC5D)-directed ... [A260890] The Committee for Medicinal Products for Human Use (CHMP) of the EMA recommended conditional ... arm comprising a heavy and light chain. …
Matched Categories: … Amino Acids, Peptides, and Proteins …
Displaying drugs 26 - 50 of 192 in total