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Displaying drugs 51 - 75 of 702 in total

Mafenide

Mafenide is a sulfonamide-type antimicrobial agent used to treat severe burns. It acts by reducing the bacterial population present in the burn tissue and promotes healing of deep burns. In 1998, mafenide acetate was approved under the FDA’s accelerated approval regulations. In November 2022, the use of mafenide acetate (powder...
Approved
Vet approved
Withdrawn
Matched Description: … It acts by reducing the bacterial population present in the burn tissue and promotes healing of deep …
Matched Categories: … Sulfur Compounds ... Folic Acid Antagonists ... Genito Urinary System and Sex Hormones ... Gynecological Antiinfectives and Antiseptics …

Silver sulfadiazine

Silver sulfadiazine is a sulfa derivative topical antibacterial used primarily on second- and third-degree burns.
Approved
Vet approved
Matched Description: … Silver sulfadiazine is a sulfa derivative topical antibacterial used primarily on second- and third-degree …
Matched Categories: … Sulfur Compounds ... Genito Urinary System and Sex Hormones ... Gynecological Antiinfectives and Antiseptics …

Cefpiramide

Cefpiramide is a third-generation cephalosporin antibiotic.
Approved
Matched Iupac: … methyl-1H-1,2,3,4-tetrazol-5-yl)sulfanyl]methyl}-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid …
Matched Categories: … Sulfur Compounds …

Sultamicillin

Sultamicillin has been used in trials studying the prevention and treatment of Ventilator Associated Pneumonia and Chronic Obstructive Pulmonary Disease (COPD).
Approved
Investigational
Matched Description: … Pneumonia and Chronic Obstructive Pulmonary Disease (COPD). ... Sultamicillin has been used in trials studying the prevention and treatment of Ventilator Associated …
Matched Categories: … Sulfur Compounds …

Prasugrel

Prasugrel, a thienopyridine derivative, is a platelet activation and aggregation inhibitor structurally and pharmacologically related to clopidogrel and ticlopidine. Similar to clopidogrel, prasugrel is a prodrug that requires enzymatic transformation in the liver to its active metabolite, R-138727. R-138727 irreversibly binds to P2Y12 type ADP receptors on platelets thus preventing...
Approved
Matched Description: … and pharmacologically related to clopidogrel and ticlopidine. ... Prasugrel was developed by Daiichi Sankyo Co. and is currently marketed in the United States and Canada ... As a result, inhibition of ADP-mediated platelet activation and aggregation occurs. …
Matched Categories: … Sulfur Compounds ... Blood and Blood Forming Organs …

Sumatriptan

Sumatriptan is a serotonin receptor agonist commonly used to treat migraines and sometimes cluster headaches.[L6793,L6796,L6799,L6805,L6808,L6811] Sumatriptan is the first of the triptans and was made available in Europe in 1991 to treat migraines. Sumatriptan was granted FDA approval on 28 December 1992.
Approved
Investigational
Matched Description: … [L6793,L6796,L6799,L6805,L6808,L6811] Sumatriptan is the first of the triptans and was made available ... Sumatriptan is a serotonin receptor agonist commonly used to treat migraines and sometimes cluster headaches …
Matched Mixtures name: … Sumatriptan and Naproxen Sodium ... Sumatriptan and Naproxen Sodium ... Sumatriptan and Naproxen Sodium …
Matched Categories: … Sulfur Compounds ... sumatriptan and naproxen ... Genito Urinary System and Sex Hormones ... Serotonin-1b and Serotonin-1d Receptor Agonist …

Cefpodoxime

Cefpodoxime is an oral third generation cephalosporin antibiotic with effectiveness against most Gram positive and Gram negative bacteria. Commonly used to treat acute otitis media, pharyngitis, and sinusitis, cefpodoxime proxetil is a prodrug which is absorbed and de-esterified by the intestinal mucosa to Cefpodoxime.
Approved
Vet approved
Matched Iupac: … 2-(methoxyimino)acetamido]-3-(methoxymethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid …
Matched Description: … which is absorbed and de-esterified by the intestinal mucosa to Cefpodoxime. ... is an oral third generation cephalosporin antibiotic with effectiveness against most Gram positive and ... Commonly used to treat acute otitis media, pharyngitis, and sinusitis, cefpodoxime proxetil is a prodrug …
Matched Categories: … Sulfur Compounds …

Amifostine

A phosphorothioate proposed as a radiation-protective agent. It causes splenic vasodilation and may block autonomic ganglia.
Approved
Investigational
Matched Iupac: … ({2-[(3-aminopropyl)amino]ethyl}sulfanyl)phosphonic acid …
Matched Description: … It causes splenic vasodilation and may block autonomic ganglia. …
Matched Categories: … Sulfur Compounds …

Cyclothiazide

As a diuretic, cyclothiazide inhibits active chloride reabsorption at the early distal tubule via the Na-Cl cotransporter, resulting in an increase in the excretion of sodium, chloride, and water. Thiazides like cyclothiazide also inhibit sodium ion transport across the renal tubular epithelium through binding to the thiazide sensitive sodium-chloride transporter....
Approved
Matched Description: … corticosteroid and estrogen therapy. ... tubule via the Na-Cl cotransporter, resulting in an increase in the excretion of sodium, chloride, and ... indicated as adjunctive therapy in edema associated with congestive heart failure, hepatic cirrhosis, and …
Matched Categories: … Sulfur Compounds ... cyclothiazide and potassium ... Genito Urinary System and Sex Hormones ... Gynecological Antiinfectives and Antiseptics …

Gliclazide

Gliclazide is an oral antihyperglycemic agent used for the treatment of non-insulin-dependent diabetes mellitus (NIDDM). It has been classified differently according to its drug properties in which based on its chemical structure, gliclazide is considered a first-generation sulfonylurea due to the structural presence of a sulfonamide group able to release...
Approved
Matched Description: … increase the number and sensitivity of insulin receptors. ... Sulfonylureas increase both basal insulin secretion and meal-stimulated insulin release. ... The risk of hypoglycemia is increased in elderly, debilitated and malnourished individuals. …
Matched Categories: … Sulfur Compounds ... Alimentary Tract and Metabolism ... Genito Urinary System and Sex Hormones ... Gynecological Antiinfectives and Antiseptics …

Rivaroxaban

Rivaroxaban is an anticoagulant and the first orally active direct factor Xa inhibitor. Unlike warfarin, routine lab monitoring of INR is not necessary. However there is no antidote available in the event of a major bleed. Only the 10 mg tablet can be taken without regard to food. The 15...
Approved
Matched Description: … Rivaroxaban is an anticoagulant and the first orally active direct factor Xa inhibitor. ... The 15 mg and 20 mg tablet should be taken with food. FDA approved on July 1, 2011. …
Matched Categories: … rivaroxaban and acetylsalicylic acid ... Sulfur Compounds ... Blood and Blood Forming Organs …

Isoxicam

Isoxicam is a non-steroidal anti-inflammatory drug that is not marketed in the United States.
Approved
Withdrawn
Matched Categories: … Sulfur Compounds …

Cefprozil

Cefprozil is a cephalosporin antibiotic that is commonly employed to treat a variety of bacterial infections, including those of the ear and skin, bronchitis, and others.
Approved
Matched Iupac: … -hydroxyphenyl)acetamido]-8-oxo-3-(prop-1-en-1-yl)-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid …
Matched Description: … skin, bronchitis, and others. ... antibiotic that is commonly employed to treat a variety of bacterial infections, including those of the ear and …
Matched Categories: … Sulfur Compounds …

Belinostat

Belinostat is a novel agent that inhibits the enzyme histone deacetylase (HDAC) with a sulfonamide-hydroxamide structure. It was developed as an orphan drug to target hematological malignancies and solid tumors by TopoTarget. The safety and efficacy of belinostat is currently being evaluated for use in combination with traditional front-line therapies...
Approved
Investigational
Matched Description: … It was developed as an orphan drug to target hematological malignancies and solid tumors by TopoTarget ... Intravenous administration of the agent is available as Beleodaq as monotherapy and the dosing regimen ... The safety and efficacy of belinostat is currently being evaluated for use in combination with traditional …
Matched Categories: … Sulfur Compounds ... Antineoplastic and Immunomodulating Agents …

Cefpirome

Approved
Matched Categories: … Sulfur Compounds …

Glipizide

Glipizide is an oral hypoglycemic agent in the second-generation sulfonylurea drug class that is used to control blood sugar levels in patients with type 2 diabetes mellitus. It was first introduced in 1984 and is available in various countries including Canada and the U.S. According to the 2018 Clinical Practice...
Approved
Investigational
Matched Description: … It was first introduced in 1984 [A179491] and is available in various countries including Canada and ... [A179485] Glipizide was first approved by the FDA in 1994 and is available in extended-release tablets ... onset of action with the shortest half-life and duration of action, reducing the risk for long-lasting …
Matched Mixtures name: … Glipizide and Metformin HCl ... Glipizide and Metformin HCl ... Glipizide and Metformin Hydrochloride …
Matched Categories: … Sulfur Compounds ... Alimentary Tract and Metabolism …

Ceftolozane

Ceftolozane is a semi-synthetic broad-spectrum fifth generation cephalosporin. It was approved by the FDA in 2014 for use in combination with Tazobactam for the treatment of serious infections, such as intra-abdominal infections and complicated urinary tract infections. The manufacturer of this drug is Cubist Pharmaceuticals. Most recently, in June 2019,...
Approved
Investigational
Matched Description: … and mortality in hospitalized patients and the use of ceftolozane-tazobactam offers effective activity ... 2019, ceftolozane-tazobactam was approved for the treatment of hospital-acquired bacterial pneumonia and ... combination with [Tazobactam] for the treatment of serious infections, such as intra-abdominal infections and …
Matched Categories: … Sulfur Compounds …

Cefadroxil

Long-acting, broad-spectrum, water-soluble, cephalexin derivative.
Approved
Vet approved
Withdrawn
Matched Iupac: … amino-2-(4-hydroxyphenyl)acetamido]-3-methyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid …
Matched Categories: … Sulfur Compounds …

Rofecoxib

Rofecoxib is used for the treatment of osteoarthritis, rheumatoid arthritis, acute pain in adults, and primary dysmenorrhea, as well as acute treatment of migraine attacks with or without auras. Rofecoxib is a solid. This compound belongs to the stilbenes. These are organic compounds containing a 1,2-diphenylethylene moiety. Stilbenes (C6-C2-C6 )...
Approved
Investigational
Withdrawn
Matched Description: … doses of 125, 25, and 50 mg is approximately 93%. ... The proteins that rofecoxib target include elastin and prostaglandin G/H synthase 2. ... Rofecoxib is used for the treatment of osteoarthritis, rheumatoid arthritis, acute pain in adults, and …
Matched Categories: … Sulfur Compounds ... Antiinflammatory and Antirheumatic Products ... Antiinflammatory and Antirheumatic Products, Non-Steroids …

Glymidine

Glycodiazine is used with diet to lower blood glucose by increasing the secretion of insulin from pancreas and increasing the sensitivity of peripheral tissues to insulin. The mechanism of action of glycodiazine in lowering blood glucose appears to be dependent on stimulating the release of insulin from functioning pancreatic beta...
Approved
Investigational
Matched Description: … Glycodiazine is used with diet to lower blood glucose by increasing the secretion of insulin from pancreas and ... appears to be dependent on stimulating the release of insulin from functioning pancreatic beta cells, and ... ATP-sensitive potassium channel receptors on the pancreatic cell surface, reducing potassium conductance and …
Matched Categories: … Sulfur Compounds ... Alimentary Tract and Metabolism ... Genito Urinary System and Sex Hormones ... Gynecological Antiinfectives and Antiseptics …

Chlormezanone

A non-benzodiazepine that is used in the management of anxiety. It has been suggested for use in the treatment of muscle spasm.
Approved
Investigational
Withdrawn
Matched Categories: … Sulfur Compounds ... Oxazol, Thiazine, and Triazine Derivatives …

Sulthiame

Approved
Matched Categories: … Sulfur Compounds ... Genito Urinary System and Sex Hormones ... Gynecological Antiinfectives and Antiseptics …

Tipranavir

Tipranavir is a sulfonamide-containing dyhydropyrone and a nonpeptidic protease inhibitor that targets the HIV protease. Tipranavir and ritonavir are coadministered to treat HIV.
Approved
Investigational
Matched Description: … Tipranavir and ritonavir are coadministered to treat HIV. ... Tipranavir is a sulfonamide-containing dyhydropyrone and a nonpeptidic protease inhibitor that targets …
Matched Categories: … Sulfur Compounds …

Glecaprevir

Glecaprevir is a direct acting antiviral agent and Hepatitis C virus (HCV) NS3/4A protease inhibitor that targets the the viral RNA replication. In combination with DB13878, glecaprevir is a useful therapy for patients who experienced therapeutic failure from other NS3/4A protease inhibitors. It demonstrates a high genetic barrier against resistance...
Approved
Investigational
Matched Description: … The combinations of amino acid substitutions at NS3 position Y65H and D/Q168 also results in greater ... In cell cultures, the emergence of amino acid substitutions at NS3 resistance-associated positions A156 ... Glecaprevir is a direct acting antiviral agent and Hepatitis C virus (HCV) NS3/4A protease inhibitor …
Matched Categories: … Sulfur Compounds ... glecaprevir and pibrentasvir ... Amino Acids, Peptides, and Proteins …

Celecoxib

Celecoxib, a selective cyclooxygenase-2 (COX-2) inhibitor, is a nonsteroidal anti-inflammatory drug (NSAID) which is known for its decreased risk of causing gastrointestinal bleeding compared to other NSAIDS. It is used to manage symptoms of various types of arthritis pain and in familial adenomatous polyposis (FAP) to reduce precancerous polyps in...
Approved
Investigational
Matched Description: … [A181544] It is used to manage symptoms of various types of arthritis pain and in familial adenomatous ... [A181532] It is marketed by Pfizer under the brand name Celebrex, and was initially granted FDA approval ... selective COX-2 inhibitors (especially celecoxib), have been evaluated as potential cancer chemopreventive and …
Matched Categories: … Sulfur Compounds ... tramadol and celecoxib ... amlodipine and celecoxib ... Antiinflammatory and Antirheumatic Products ... Genito Urinary System and Sex Hormones …
Displaying drugs 51 - 75 of 702 in total