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Displaying drugs 76 - 100 of 2648 in total

Nadofaragene firadenovec

Nadofaragene firadenovec (nadofaragene firadenovec-vncg) is a recombinant non-replicating adenovirus serotype 5 vector containing a transgene encoding human interferon alfa-2b (IFNα2b). It was approved by the FDA on December 2022 for the treatment of high-risk Bacillus Calmette-Guérin (BCG)-unresponsive non-muscle invasive bladder cancer (NMIBC) with carcinoma in situ (CIS) with or without...
Approved
Investigational
Matched Synonyms: … Replication-deficient adenovirus type 5 (ad5) vector encoding the human interferon alpha 2 (ifna2, interferon …
Matched Description: … serotype 5 vector containing a transgene encoding human interferon alfa-2b (IFNα2b). ... Nadofaragene firadenovec (nadofaragene firadenovec-vncg) is a recombinant non-replicating adenovirus …
Matched Categories: … Recombinant Proteins …

Nuvaxovid

SARS-CoV-2, the causative agent of COVID-19, relies on the interaction between its trimeric spike (S) glycoprotein and angiotensin-converting enzyme 2 (hACE2) expressed on host cells in order to establish a productive infection in humans. Antibodies directed against the S protein are capable of blocking S-hACE2 interactions and neutralizing viral particles...
Approved
Investigational
Matched Description: … Nuvaxovid (NVX-CoV2373) contains a recombinant mutant S protein that is codon-optimized for baculovirus-mediated ... SARS-CoV-2, the causative agent of COVID-19, relies on the interaction between its trimeric spike (S) ... particles and are present in convalescent patients and those who have been inoculated against COVID-19 …
Matched Categories: … COVID-19 Vaccines …
Matched Products: … NOVAVAX COVID-19 Vaccine, Adjuvanted …

Lonoctocog alfa

Approved
Investigational
Matched Products: … AFSTYLA Antihemophilic Factor (Recombinant), Single Chain …

Imelasomeran

Imelasomeran was first approved in Canada on September 1, 2022, as one-half of Moderna's Spikevax Bivalent COVID-19 mRNA vaccine. It encodes for the viral spike protein of the Omicron BA.1 variant of SARS-CoV-2, a particularly infectious variant of concern first documented in 2021.
Approved
Investigational
Matched Description: … was first approved in Canada on September 1, 2022, as one-half of Moderna's Spikevax Bivalent COVID-19 …
Matched Categories: … COVID-19 Vaccines …
Matched Products: … Moderna COVID-19 Vaccine, Bivalent …

Atidarsagene autotemcel

Atidarsagene autotemcel, sold under the brand name Libmeldy, is a gene therapy comprising genetically modified autologous CD34+ enriched hematopoietic stem and progenitor cells transduced ex vivo using a lentiviral vector encoding the human arylsulfatase A (ARSA) gene. Libmeldy was granted orphan designation by the EMA in April 2007, and was...
Approved
Matched Synonyms: … haematopoietic stem and progenitor cells (HSPC) transduced ex vivo using a lentiviral vector encoding the human …
Matched Description: … hematopoietic stem and progenitor cells transduced _ex vivo_ using a lentiviral vector encoding the human …

Butylene glycol

Approved
Experimental
Matched Products: … SiYi Human Body Lubricant ... Human Body Lubricant R170009 …

Potassium carbonate

Potassium carbonate (K2CO3) is a white salt, soluble in water (insoluble in ethanol) which forms a strongly alkaline solution. It can be made as the product of potassium hydroxide's absorbent reaction with carbon dioxide. It presents a large capacity to absorb moisture.
Approved
Matched Products: … Sanitalk - Sanitizer(covid-19) …

Allantoin

Allantoin is a substance that is endogenous to the human body and also found as a normal component of human diets [FDA Label]. In healthy human volunteers, the mean plasma concentration of allantoin is about 2-3 mg/l. During exercise, the plasma allantoin concentration rapidly increases about two fold and remains...
Approved
Matched Description: … human diets [FDA Label]. ... In human muscle, urate is oxidized to allantoin during such exercise [FDA Label]. ... In healthy human volunteers, the mean plasma concentration of allantoin is about 2-3 mg/l. …

Bamlanivimab

Bamlanivimab (LY-CoV555, also known as LY3819253), is a synthetic monoclonal antibody (mAb) derived from one of the first blood samples in the United States from a patient who recovered from COVID-19.[A224039, L15311, L15316] Bamlanivimab is a neutralizing IgG1κ mAb directed against the SARS-CoV-2 spike (S) protein, which is described to...
Approved
Investigational
Matched Description: … mAb directed against the SARS-CoV-2 spike (S) protein, which is described to block viral entry into human ... derived from one of the first blood samples in the United States from a patient who recovered from COVID-19 ... L40174] The EUA currently allows bamlanivimab and etesevimab for post-exposure prophylaxis of COVID-19 …
Matched Categories: … Experimental Unapproved Treatments for COVID-19 …

Olipudase alfa

Olipudase alfa is recombinant human acid sphingomyelinase. It is the first and only enzyme replacement therapy in the world for the treatment of Acid Sphingomyelinase Deficiency (ASMD), also known as Niemann–Pick disease. ASMD is a rare lysosomal storage disease caused by mutations in the SMPD1 gene, leading to a deficiency...
Approved
Investigational
Matched Description: … Olipudase alfa is recombinant human acid sphingomyelinase. …
Matched Categories: … Recombinant Proteins …

Basiliximab

A recombinant chimeric (murine/human) monoclonal antibody (IgG1k) that functions as an immunosuppressive agent, specifically binding to and blocking the interleukin-2 receptor a-chain (IL-2R alpha, also known as CD25 antigen) on the surface of activated T-lymphocytes. It is a 144 kDa glycoprotein obtained from fermentation of an established mouse myeloma cell...
Approved
Investigational
Matched Description: … A recombinant chimeric (murine/human) monoclonal antibody (IgG1k) that functions as an immunosuppressive ... agent, specifically binding to and blocking the interleukin-2 receptor a-chain (IL-2R alpha, also known ... of an established mouse myeloma cell line genetically engineered to express plasmids containing the human …
Matched Categories: … Interleukin Inhibitors ... Interleukin-2 Receptor Antagonist ... Interleukin-2 Receptor Blocking Antibody ... Interleukin 2 Receptor-directed Antibody Interactions …

Tocilizumab

Tocilizumab is a recombinant humanized monoclonal antibody IL-6 receptor inhibitor used to treat inflammatory and autoimmune conditions. It was first described in the literature in 2003 when Chugai, a subsidiary of Roche began developing IL-6 inhibiting monoclonal antibodies. Tocilizumab was granted FDA approval on 8 January 2010 to treat a...
Approved
Matched Description: … Tocilizumab is a recombinant humanized monoclonal antibody IL-6 receptor inhibitor used to treat inflammatory ... [L43697] After being investigated to treat severely ill patients with COVID-19,[A193278,L12837,L12843 ... ] tocilizumab was approved by the European Commission in December 2021 to treat COVID-19 in adults receiving …
Matched Categories: … Experimental Unapproved Treatments for COVID-19 ... Interleukin Inhibitors ... Interleukin-6 Receptor Antagonist …

Pimecrolimus

Pimecrolimus is an immunomodulating agent that was first marketed by Novartis under the trade name Elidel. It is now promoted in Canada by Galderma since early 2007. It is currently available as a topic cream used in the treatment of atopic dermatitis (eczema).
Approved
Investigational

Secukinumab

Secukinumab is a fully human monoclonal IgG1/κ antibody against interleukin-17A (IL-17A), a proinflammatory cytokine implicated in various chronic immune-mediated inflammatory disorders, such as plaque psoriasis. By blocking the actions of IL-17A, secukinumab works to inhibit the pro-inflammatory pathways that drive immune-mediated inflammatory disorders. Following its first global approval in Japan...
Approved
Matched Description: … Secukinumab is a fully human monoclonal IgG1/κ antibody against interleukin-17A (IL-17A), a proinflammatory …
Matched Categories: … Interleukin Inhibitors ... Interleukin-17A Antagonist ... Interleukin-17, antagonists & inhibitors …

Risankizumab

Risankizumab is a fully humanized IgG1 monoclonal antibody (mAb) directed against interleukin 23 (IL-23). It gained its first global approval in Japan in March 2019, followed by approval in Canada, the US, and Europe in April 2019. Risankizumab is used to treat plaque psoriasis, psoriatic arthritis, and Crohn's disease.[L39885,L44191,L44231] Risankizumab...
Approved
Investigational
Matched Description: … Risankizumab is a fully humanized IgG1 monoclonal antibody (mAb) directed against interleukin 23 (IL- …
Matched Categories: … Interleukin Inhibitors ... Interleukin-23 Antagonist ... Interleukin-23 Subunit p19 …

Ustekinumab

Ustekinumab is a human immunoglobulin (Ig) G1 kappa monoclonal antibody directed against interleukin(IL)-12 and IL-23, which are cytokines that are involved in immune and inflammatory responses. It was generated via recombinant human IL-12 immunization of human Ig (hu-Ig) transgenic mice. It is a targeted biologic disease-modifying anti-rheumatic drug (bDMARDs) that...
Approved
Investigational
Matched Description: … [A187349] It was generated via recombinant human IL-12 immunization of human Ig (hu-Ig) transgenic mice ... Ustekinumab is a human immunoglobulin (Ig) G1 kappa monoclonal antibody directed against interleukin( ... Ustekinumab is currently the first and only approved biologic therapy for ulcerative colitis that targets the interleukin …
Matched Categories: … Interleukin Inhibitors ... Interleukin-12 Antagonist ... Interleukin-23 Antagonist …

Eflapegrastim

Febrile neutropenia (FN), defined as the co-occurrence of fever (temperature > 38 ◦C) and severe neutropenia (ANC < 500 cells/mm3), is a potential side effect of myelosuppressive chemotherapy in which the patient develops an infection during a period of significant neutropenia. It typically develops during the first cycle of chemotherapy...
Approved
Investigational
Matched Description: … [L43135] Eflapegrastim is a form of recombinant human G-CSF comprising a human G-CSF analog coupled ... to the Fc fragment of human IgG4 via a polyethylene glycol linker. …

Ribavirin

Producing a broad-spectrum activity against several RNA and DNA viruses, Ribavirin is a synthetic guanosine nucleoside and antiviral agent that interferes with the synthesis of viral mRNA. It is primarily indicated for use in treating hepatitis C and viral hemorrhagic fevers. HCV is a single-stranded RNA virus that is categorized...
Approved
Matched Mixtures name: … Rebetron Solution (albumin (human) Free) (18 Miu Multi-dose Pen / 200mg Capsules) ... Rebetron Ready To Use Solution (albumin(human)free) (6000000 Iu/ml and 200mg Capsules) …

Dupilumab

Dupilumab is a fully human monoclonal antibody of the immunoglobulin G4 subclass that binds to the interleukin-4 (IL-4) receptor, inhibiting the receptor signaling pathways. As an interleukin-4 receptor alpha antagonist, dupilumab inhibits the signaling of pro-inflammatory cytokines, called interleukins (IL), that induce inflammatory and immunological reactions in several atopic or...
Approved
Investigational
Matched Description: … Dupilumab is a fully human monoclonal antibody of the immunoglobulin G4 subclass that binds to the interleukin ... [A180478] Dupilumab was generated by recombinant DNA technology in Chinese Hamster Ovary cell suspension ... [A180478] As an interleukin-4 receptor alpha antagonist, dupilumab inhibits the signaling of pro-inflammatory …
Matched Categories: … Interleukin-4 Receptor alpha Antagonist ... Interleukin 4 Receptor alpha Antagonists ... Interleukin-4 Receptor alpha Subunit, antagonists & inhibitors …

Corynebacterium diphtheriae CRM197 protein

Approved

Peginterferon alfa-2b

Peginterferon alfa-2b is a form of recombinant interferon used as part of combination therapy to treat chronic Hepatitis C, an infectious liver disease caused by infection with Hepatitis C Virus (HCV). HCV is a single-stranded RNA virus that is categorized into nine distinct genotypes, with genotype 1 being the most...
Approved
Matched Description: … Peginterferon alfa-2b is derived from the alfa-2b moeity of recombinant human interferon and acts by ... binding to human type 1 interferon receptors. ... Peginterferon alfa-2b is a form of recombinant interferon used as part of combination therapy to treat …

Rurioctocog alfa pegol

Rurioctocog alfa pegol is a pegylated recombinant human coagulation factor VIII or antihemophilic factor. Factor VIII is an essential protein involved in normal blood clotting; thus, a deficient level of functional factor VIII is associated with an elevated risk for excessive bleeding caused by spontaneous or secondary events like trauma...
Approved
Experimental
Matched Description: … Rurioctocog alfa pegol is a pegylated recombinant human coagulation factor VIII or antihemophilic factor ... factor VIII produced by recombinant DNA technology from a Chinese hamster ovary cell line. ... [L40119] Rurioctocog alfa pegol is a covalent conjugate of [octocog alfa], which is a recombinant …
Matched Categories: … Recombinant Proteins …

Casirivimab

Casirivimab is a monoclonal antibody combined with Imdevimab in Regeneron's antibody cocktail known as REGN-COV2 for the treatment of COVID-19. This drug is a combination of antibodies derived from humanized VelocImmune® mice in addition to blood samples from patients who have recovered from COVID-19. These antibodies have been formulated to...
Approved
Experimental
Matched Description: … Casirivimab and imdevimab are investigational recombinant human IgG1 monoclonal antibodies that, at this ... combined with [Imdevimab] in Regeneron's antibody cocktail known as REGN-COV2 for the treatment of COVID-19 ... humanized VelocImmune® mice in addition to blood samples from patients who have recovered from COVID-19 …
Matched Categories: … Approved Treatments for COVID-19 …

Pegloticase

Pegloticase is a porcine recombinant PEGylated uricase indicated for the treatment of chronic gout in adult patients that do not respond to other types of therapies. Pegloticase has a similar activity to rasburicase, an enzyme that metabolizes uric acid to allantoin. In gout patients treated with pegloticase, the conversion of...
Approved
Investigational
Matched Description: … Pegloticase is a porcine recombinant PEGylated uricase indicated for the treatment of chronic gout in …
Matched Categories: … Recombinant Proteins …

Vortioxetine

Vortioxetine is an antidepressant medication indicated for the treatment of major depressive disorder (MDD). It is classified as a serotonin modulator and stimulator (SMS) as it has a multimodal mechanism of action towards the serotonin neurotransmitter system whereby it simultaneously modulates one or more serotonin receptors and inhibits the reuptake...
Approved
Investigational
Displaying drugs 76 - 100 of 2648 in total