Displaying drugs 2376 - 2400 of 15512 in total
Demecarium
Demecarium is an indirect-acting parasympathomimetic agent that is used to treat glaucoma. It is a cholinesterase inhibitor or an anticholinesterase. Cholinesterase inhibitors prolong the effect of acetylcholine, which is released at the neuroeffector junction of parasympathetic postganglion nerves, by inactivating the cholinesterases that break it down. Demecarium inactivates both pseudocholinesterase...
Approved
Matched Iupac: … N,N,N-trimethyl-3-{[methyl({10-[methyl({[3-(trimethylazaniumyl)phenoxy]carbonyl})amino]decyl})carbamoyl …
Matched Description: … Demecarium inactivates both pseudocholinesterase and acetylcholinesterase. ... In the eye, this causes constriction of the iris sphincter muscle (causing miosis) and the ciliary muscle …
Matched Categories: … Antiglaucoma Preparations and Miotics …
Matched Description: … Demecarium inactivates both pseudocholinesterase and acetylcholinesterase. ... In the eye, this causes constriction of the iris sphincter muscle (causing miosis) and the ciliary muscle …
Matched Categories: … Antiglaucoma Preparations and Miotics …
Plasma protein fraction (human)
The plasma protein fraction human (PPFh) is defined as a sterile solution of proteins composed mainly of albumin and globulin derived from human plasma. It is already reviewed under the category of biologics by the FDA where the processing, required tests, requirements and labeling are incorporated. This biologic should come...
Approved
Matched Description: … [L2262] The proteins in PPFh are stabilized with sodium caprylate and acetyltryptophan and it contains ... some electrolytes such as sodium, potassium and chloride. ... protein fraction human (PPFh) is defined as a sterile solution of proteins composed mainly of albumin and …
Matched Categories: … Amino Acids, Peptides, and Proteins …
Matched Categories: … Amino Acids, Peptides, and Proteins …
Letermovir
Letermovir recieved approval from the FDA on November 8th, 2017 for use in prophylaxis of cytomegalovirus (CMV) infection in allogeneic hematopoietic stem cell transplant patients. It is the first of a new class of CMV anti-infectives called DNA terminase complex inhibitors. Letermovir has recieved both priority and orphan drug status...
Approved
Investigational
Matched Iupac: … -5-(trifluoromethyl)phenyl]-2-[4-(3-methoxyphenyl)piperazin-1-yl]-3,4-dihydroquinazolin-4-yl]acetic acid …
Matched Description: … [A31290] Letermovir has recieved both priority and orphan drug status from the FDA. …
Matched Description: … [A31290] Letermovir has recieved both priority and orphan drug status from the FDA. …
Vonicog alfa
Vonicog alfa is a recombinant von Willebrand factor manufactured by Baxalta. It was FDA approved in December 2015. The gen of von Willebrand factor was first cloned in 1985 by Stuart Orkin and David Ginsburg. By the EMA, vonicog alfa is still under clinical analysis.
Approved
Investigational
Matched Description: … [A32230] The gen of von Willebrand factor was first cloned in 1985 by Stuart Orkin and David Ginsburg …
Modafinil
Modafinil is a stimulant drug marketed as a 'wakefulness promoting agent' and is one of the stimulants used in the treatment of narcolepsy. Narcolepsy is caused by dysfunction of a family of wakefulness-promoting and sleep-suppressing peptides, the orexins, whose neurons are activated by modafinil. The prexin neuron activation is associated...
Approved
Investigational
Matched Description: … The prexin neuron activation is associated with psychoactivation and euphoria. ... Modafinil is a stimulant drug marketed as a 'wakefulness promoting agent' and is one of the stimulants ... Narcolepsy is caused by dysfunction of a family of wakefulness-promoting and sleep-suppressing peptides …
Matched Categories: … Modafinil and isomer ... Metabolic Side Effects of Drugs and Substances ... Psychostimulants, Agents Used for ADHD and Nootropics …
Matched Categories: … Modafinil and isomer ... Metabolic Side Effects of Drugs and Substances ... Psychostimulants, Agents Used for ADHD and Nootropics …
Aurothioglucose
Aurothioglucose, also known as gold thioglucose, was formerly used to treat rheumatoid arthritis.
Contemporary research on the effect of gold salts treatment began in 1935, primarily to reduce inflammation and to slow disease progression in patients with rheumatoid arthritis . The use of gold compounds has decreased since the 1980s...
Approved
Withdrawn
Matched Description: … use of gold compounds has decreased since the 1980s owing to numerous side effects, limited efficacy, and ... Contemporary research on the effect of gold salts treatment began in 1935, primarily to reduce inflammation and ... replaced with the use of various current disease modifying anti-rheumatic drugs (DMARDs) like methotrexate and …
Matched Categories: … Antiinflammatory and Antirheumatic Products …
Matched Categories: … Antiinflammatory and Antirheumatic Products …
Olive oil
Oil extracted from olives . Consists primarily of the glycerides of the fatty acids linoleic, oleic and palmitic. Used as a source of fatty acids in total parenteral nutrition and as an additive in some cosmetic products [FDA Label].
Approved
Matched Description: … Consists primarily of the glycerides of the fatty acids linoleic, oleic and palmitic. ... Used as a source of fatty acids in total parenteral nutrition and as an additive in some cosmetic products …
Matched Categories: … Diet, Food, and Nutrition …
Matched Categories: … Diet, Food, and Nutrition …
Saw palmetto
Saw palmetto is a plant/plant extract used in some OTC (over-the-counter) products. It is not an approved drug.
Approved
Experimental
Investigational
Matched Categories: … Herbs and Natural Products …
Zotepine
Zotepine, with the formula (2-chloro-11-(2-dimethyl-amino-ethoxy)-dibenzo thiepin, is a neuroleptic drug. It was designed and synthesized by Fujisawa Pharmaceutical Co Ltd. It has been used as an antipsychotic in Japan, India and some places in Europe like UK and Germany since 1980's. Zotepine was never approved by the FDA. In 1993,...
Approved
Investigational
Withdrawn
Matched Description: … [A31855] It has been used as an antipsychotic in Japan, India and some places in Europe like UK and Germany ... It was designed and synthesized by Fujisawa Pharmaceutical Co Ltd. ... In 1993, it was classified as inactive drug substance (Status I, Type II) and in 1995 the FDA studied …
Nirmatrelvir
Nirmatrelvir (PF-07321332) is an orally bioavailable 3C-like protease (3CLPRO) inhibitor that is the subject of clinical trial NCT04756531. 3CLPRO is responsible for cleaving polyproteins 1a and 1ab of SARS-CoV-2. Without the activity of the SARS-CoV-2 3CLPRO, nonstructural proteins (including proteases) cannot be released to perform their functions, inhibiting viral replication.[A234224,A234229,A234234]...
Approved
Investigational
Matched Description: … [L33354] 3CLPRO is responsible for cleaving polyproteins 1a and 1ab of SARS-CoV-2. ... in Canada in January 2022 for the treatment of adult patients with mild-moderate COVID-19 [L39544] and ... granted an emergency use authorization to Paxlovid, a co-packaged product containing both nirmatrelvir and …
Matched Categories: … nirmatrelvir and ritonavir ... Amino Acids, Peptides, and Proteins …
Matched Categories: … nirmatrelvir and ritonavir ... Amino Acids, Peptides, and Proteins …
Fedratinib
Fedratinib, also known as SAR302503 and TG101348, is a tyrosine kinase inhibitor used to treat intermediate-2 and high risk primary and secondary myelofibrosis.[A183176,L8090] It is an anilinopyrimidine derivative. Fedratinib was granted FDA approval on August 16, 2019.
Approved
Investigational
Matched Iupac: … N-tert-butyl-3-{[5-methyl-2-({4-[2-(pyrrolidin-1-yl)ethoxy]phenyl}amino)pyrimidin-4-yl]amino}benzene- …
Matched Description: … -2 and high risk primary and secondary myelofibrosis. ... Fedratinib, also known as SAR302503 and TG101348, is a tyrosine kinase inhibitor used to treat intermediate …
Matched Categories: … Antineoplastic and Immunomodulating Agents ... Genito Urinary System and Sex Hormones ... Gynecological Antiinfectives and Antiseptics …
Matched Description: … -2 and high risk primary and secondary myelofibrosis. ... Fedratinib, also known as SAR302503 and TG101348, is a tyrosine kinase inhibitor used to treat intermediate …
Matched Categories: … Antineoplastic and Immunomodulating Agents ... Genito Urinary System and Sex Hormones ... Gynecological Antiinfectives and Antiseptics …
Lenvatinib
Lenvatinib is a receptor tyrosine kinase (RTK) inhibitor that inhibits the kinase activities of vascular endothelial growth factor (VEGF) receptors VEGFR1 (FLT1), VEGFR2 (KDR), and VEGFR3 (FLT4). Lenvatinib also inhibits other RTKs that have been implicated in pathogenic angiogenesis, tumor growth, and cancer progression in addition to their normal cellular...
Approved
Investigational
Matched Description: … differentiation, and in pathogenic angiogenesis, lymphogenesis, tumour growth and cancer progression ... 4; the platelet derived growth factor receptor alpha (PDGFRα), KIT, and RET. ... kinase activities of vascular endothelial growth factor (VEGF) receptors VEGFR1 (FLT1), VEGFR2 (KDR), and …
Matched Categories: … Antineoplastic and Immunomodulating Agents …
Matched Categories: … Antineoplastic and Immunomodulating Agents …
Sulfur hexafluoride
Sulfur hexafluoride is an ultrasound contrast agent indicated for use
•in echocardiography to opacify the left ventricular chamber and to improve the delineation of the left ventricular endocardial border in adult patients with suboptimal echocardiograms
•in ultrasonography of the liver for characterization of focal liver lesions in adult and pediatric...
Approved
Matched Description: … ultrasound contrast agent indicated for use
•in echocardiography to opacify the left ventricular chamber and ... echocardiograms
•in ultrasonography of the liver for characterization of focal liver lesions in adult and …
Amifostine
A phosphorothioate proposed as a radiation-protective agent. It causes splenic vasodilation and may block autonomic ganglia.
Approved
Investigational
Matched Iupac: … ({2-[(3-aminopropyl)amino]ethyl}sulfanyl)phosphonic acid …
Matched Description: … It causes splenic vasodilation and may block autonomic ganglia. …
Matched Description: … It causes splenic vasodilation and may block autonomic ganglia. …
Ferric ammonium citrate
Approved
Experimental
Matched Iupac: … iron(3+) 2-hydroxypropane-1,2,3-tricarboxylic acid amine …
Dihydrostreptomycin
Dihydrostreptomycin is an aminoglycoside antibiotic. In humans, the use of dihydrostreptomycin has been associated with ototoxicity. The FDA withdrew its approval for the use of all drug products containing dihydrostreptomycin sulfate.
Approved
Investigational
Vet approved
Withdrawn
Isoxicam
Isoxicam is a non-steroidal anti-inflammatory drug that is not marketed in the United States.
Approved
Withdrawn
Matched Iupac: … 4-hydroxy-2-methyl-N-(5-methyl-1,2-oxazol-3-yl)-1,1-dioxo-2H-1lambda6,2-benzothiazine-3-carboxamide …
Tralokinumab
Atopic dermatitis (AD) is an inflammatory skin disorder that causes skin inflammation, skin barrier dysfunction, and chronic pruritus. It is estimated to affect up to 20% of adults and children worldwide, and is frequently associated with other atopic conditions such as asthma or allergic rhinitis. While AD is a heterogenous...
Approved
Investigational
Matched Description: … [A242432] It is estimated to affect up to 20% of adults and children worldwide, and is frequently associated ... was subsequently approved in Canada in October 2021 and the US in December 2021. ... dermatitis (AD) is an inflammatory skin disorder that causes skin inflammation, skin barrier dysfunction, and …
Matched Categories: … Amino Acids, Peptides, and Proteins …
Matched Categories: … Amino Acids, Peptides, and Proteins …
Piflufolastat F 18
Prostate cancer is the most common non-cutaneous malignancy affecting men in North America - despite this, an ongoing challenge in prostate cancer therapy is the difficulty in imaging the extent and location of tumor metastases and recurrences. The images generated by positron emission tomography (PET) are less detailed than those...
Approved
Investigational
Matched Iupac: … 2S)-2-({[(1S)-1-carboxy-5-{[6-(¹⁸F)fluoropyridin-3-yl]formamido}pentyl]carbamoyl}amino)pentanedioic acid …
Matched Description: … location of tumor metastases and recurrences. ... and more accurate detection of suspected prostate cancer metastases or recurrences. ... despite this, an ongoing challenge in prostate cancer therapy is the difficulty in imaging the extent and …
Matched Categories: … Amino Acids, Peptides, and Proteins …
Matched Description: … location of tumor metastases and recurrences. ... and more accurate detection of suspected prostate cancer metastases or recurrences. ... despite this, an ongoing challenge in prostate cancer therapy is the difficulty in imaging the extent and …
Matched Categories: … Amino Acids, Peptides, and Proteins …
Rituximab
Rituximab is a genetically engineered chimeric murine/human monoclonal antibody directed against the CD20 antigen found on the surface of normal and malignant B lymphocytes. The antibody is an IgG1 kappa immunoglobulin containing murine light and heavy-chain variable region sequences and human constant region sequences , [FDA label]. It was originally...
Approved
Matched Description: … sequences and human constant region sequences [A40017], [FDA label]. ... The antibody is an IgG1 kappa immunoglobulin containing murine light and heavy-chain variable region ... chimeric murine/human monoclonal antibody directed against the CD20 antigen found on the surface of normal and …
Matched Categories: … Amino Acids, Peptides, and Proteins ... MONOCLONAL ANTIBODIES AND ANTIBODY DRUG CONJUGATES …
Matched Categories: … Amino Acids, Peptides, and Proteins ... MONOCLONAL ANTIBODIES AND ANTIBODY DRUG CONJUGATES …
Cefiderocol
Cefiderocol is a cephalosporin antibacterial drug and exerts a mechanism of action similar to other β-lactam antibiotics.[FDA Label] Unlike other agents in this category, cefiderocol is a siderophore able to undergo active transport into the bacterial cell through iron channels. It represents a significant addition to antibacterial treatment option as...
Approved
Investigational
Matched Iupac: … carboxy-1-methylethoxy)imino]acetamido]-2-carboxylato-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-en-3-yl]methyl …
Matched Description: … Cefiderocol is a cephalosporin antibacterial drug and exerts a mechanism of action similar to other β-lactam ... Cefiderocol was granted designation as a Qualified Infectious Disease Product and granted priority review ... effective *in vitro* against multidrug resistant strains including extended spectrum β-lactamase producers and …
Matched Description: … Cefiderocol is a cephalosporin antibacterial drug and exerts a mechanism of action similar to other β-lactam ... Cefiderocol was granted designation as a Qualified Infectious Disease Product and granted priority review ... effective *in vitro* against multidrug resistant strains including extended spectrum β-lactamase producers and …
Flotufolastat F-18
Flotufolastat F-18 (18F-rhPSMA-7.3) is an 18F-labeled ligand that targets the prostate-specific membrane antigen (PSMA).[A259846,L46731] In patients with recurrent prostate cancer that require localized treatment, the use of 18F-labeled ligands for positron emission tomography (PET) offers accurate diagnostic imaging. Unlike 68Ga-labeled PSMA-targeting ligands, 18F-labeled compounds targeting this protein have a longer...
Approved
Investigational
Matched Iupac: … formamido)propanamido]pentyl]carbamoyl}propanamido)butyl]carbamoyl}propyl]carbamoyl}amino)pentanedioic acid …
Matched Description: … of this compound, flotufolastat F-18 has a faster clearance from blood pool, liver, and kidney, and ... a good distinction between primary-tumor activity and bladder background activity. ... PSMA-targeting ligands, 18F-labeled compounds targeting this protein have a longer half-life and …
Matched Description: … of this compound, flotufolastat F-18 has a faster clearance from blood pool, liver, and kidney, and ... a good distinction between primary-tumor activity and bladder background activity. ... PSMA-targeting ligands, 18F-labeled compounds targeting this protein have a longer half-life and …
Prasterone enantate
Approved
Matched Categories: … Hormones, Hormone Substitutes, and Hormone Antagonists …
Displaying drugs 2376 - 2400 of 15512 in total