Olive oil

Identification

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Name
Olive oil
Accession Number
DB09567
Type
Small Molecule
Groups
Approved
Description

Oil extracted from olives 1. Consists primarily of the glycerides of the fatty acids linoleic, oleic and palmitic. Used as a source of fatty acids in total parenteral nutrition and as an additive in some cosmetic products Label.

Synonyms
Not Available
Over the Counter Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Intensive Treatment Bodyoil for Mommy To Be All SkinOil49.742 g/100mLTopicalIn This Morning2018-12-11Not applicableUs
Additional Data Available
  • Application Number
    Application Number

    A unique ID assigned by the FDA when a product is submitted for approval by the labeller.

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  • Product Code
    Product Code

    A governmentally-recognized ID which uniquely identifies the product within its regulatory market.

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Mixture Products
NameIngredientsDosageRouteLabellerMarketing StartMarketing End
Clinoleic 20%Olive oil (16 %) + Soybean oil (4 %)EmulsionIntravenousBaxter Laboratories2012-03-28Not applicableCanada
ClinolipidOlive oil (16 g/100mL) + Soybean oil (4 g/100mL)Injection, emulsionIntravenousBaxter Healthcare Corporation2016-01-01Not applicableUs
Olimel 3.3% EOlive oil (32 g) + Aspartic acid (0.95 g) + Calcium Chloride (0.52 g) + Dextrose, unspecified form (126.5 g) + Glutamic Acid (1.64 g) + Glycine (2.28 g) + Histidine (1.96 g) + Isoleucine (1.64 g) + L-Alanine (4.76 g) + L-Arginine (3.22 g) + L-Leucine (2.28 g) + L-Lysine acetate (2.59 g) + L-Phenylalanine (2.28 g) + L-Threonine (1.64 g) + L-Tryptophan (0.55 g) + L-Valine (2.1 g) + Magnesium chloride (0.81 g) + Methionine (1.64 g) + Potassium chloride (2.24 g) + Proline (1.96 g) + Serine (1.30 g) + Sodium acetate trihydrate (1.50 g) + Sodium glycerophosphate (3.67 g) + Soybean oil (8 g) + Tyrosine (0.08 g)EmulsionIntravenousBaxter LaboratoriesNot applicableNot applicableCanada
Olimel 4.4%Olive oil (32 g) + Aspartic acid (1.28 g) + Dextrose, unspecified form (154 g) + Glutamic Acid (2.21 g) + Glycine (3.07 g) + Histidine (2.64 g) + Isoleucine (2.21 g) + L-Alanine (6.41 g) + L-Arginine (4.34 g) + L-Leucine (3.07 g) + L-Lysine acetate (3.48 g) + L-Phenylalanine (3.07 g) + L-Threonine (2.21 g) + L-Tryptophan (0.74 g) + L-Valine (2.83 g) + Methionine (2.21 g) + Proline (2.64 g) + Serine (1.75 g) + Soybean oil (8 g) + Tyrosine (0.11 g)EmulsionIntravenousBaxter Laboratories2011-09-29Not applicableCanada
Olimel 4.4% EOlive oil (32 g) + Aspartic acid (1.28 g) + Calcium Chloride (0.52 g) + Dextrose, unspecified form (154 g) + Glutamic Acid (2.21 g) + Glycine (3.07 g) + Histidine (2.64 g) + Isoleucine (2.21 g) + L-Alanine (6.41 g) + L-Arginine (4.34 g) + L-Leucine (3.07 g) + L-Lysine acetate (3.48 g) + L-Phenylalanine (3.07 g) + L-Threonine (2.21 g) + L-Tryptophan (0.74 g) + L-Valine (2.83 g) + Magnesium chloride (0.81 g) + Methionine (2.21 g) + Potassium chloride (2.24 g) + Proline (2.64 g) + Serine (1.75 g) + Sodium acetate trihydrate (1.50 g) + Sodium glycerophosphate (3.67 g) + Soybean oil (8 g) + Tyrosine (0.11 g)EmulsionIntravenousBaxter Laboratories2011-02-26Not applicableCanada
Olimel 5.7%Olive oil (32 g) + Aspartic acid (1.65 g) + Dextrose, unspecified form (121 g) + Glutamic Acid (2.84 g) + Glycine (3.95 g) + Histidine (3.40 g) + Isoleucine (2.84 g) + L-Alanine (8.24 g) + L-Arginine (5.58 g) + L-Leucine (3.95 g) + L-Lysine acetate (4.48 g) + L-Phenylalanine (3.95 g) + L-Threonine (2.84 g) + L-Tryptophan (0.95 g) + L-Valine (3.64 g) + Methionine (2.84 g) + Proline (3.40 g) + Serine (2.25 g) + Soybean oil (8 g) + Tyrosine (0.15 g)EmulsionIntravenousBaxter Laboratories2011-03-01Not applicableCanada
Olimel 5.7% EOlive oil (32 g) + Aspartic acid (1.65 g) + Calcium Chloride (0.52 g) + Dextrose, unspecified form (121 g) + Glutamic Acid (2.84 g) + Glycine (3.95 g) + Histidine (3.40 g) + Isoleucine (2.84 g) + L-Alanine (8.24 g) + L-Arginine (5.58 g) + L-Leucine (3.95 g) + L-Lysine acetate (4.48 g) + L-Phenylalanine (3.95 g) + L-Threonine (2.84 g) + L-Tryptophan (0.95 g) + L-Valine (3.64 g) + Magnesium chloride (0.81 g) + Methionine (2.84 g) + Potassium chloride (2.24 g) + Proline (3.40 g) + Serine (2.25 g) + Sodium acetate trihydrate (1.50 g) + Sodium glycerophosphate (3.67 g) + Soybean oil (8 g) + Tyrosine (0.15 g)EmulsionIntravenousBaxter Laboratories2011-01-19Not applicableCanada
Olimel 7.6%Olive oil (28 g) + Aspartic acid (2.2 g) + Dextrose, unspecified form (80.67 g) + Glutamic Acid (3.79 g) + Glycine (5.26 g) + Histidine (4.53 g) + Isoleucine (3.79 g) + L-Alanine (10.99 g) + L-Arginine (7.44 g) + L-Leucine (5.26 g) + L-Lysine acetate (5.97 g) + L-Phenylalanine (5.26 g) + L-Threonine (3.79 g) + L-Tryptophan (1.26 g) + L-Valine (4.86 g) + Methionine (3.79 g) + Proline (4.53 g) + Serine (3 g) + Soybean oil (7 g) + Tyrosine (0.2 g)EmulsionIntravenousBaxter LaboratoriesNot applicableNot applicableCanada
Olimel 7.6% EOlive oil (28 g) + Aspartic acid (2.2 g) + Calcium Chloride (0.52 g) + Dextrose, unspecified form (80.67 g) + Glutamic Acid (3.79 g) + Glycine (5.26 g) + Histidine (4.53 g) + Isoleucine (3.79 g) + L-Alanine (10.99 g) + L-Arginine (7.44 g) + L-Leucine (5.26 g) + L-Lysine acetate (5.97 g) + L-Phenylalanine (5.26 g) + L-Threonine (3.79 g) + L-Tryptophan (1.26 g) + L-Valine (4.86 g) + Magnesium chloride (0.81 g) + Methionine (3.79 g) + Potassium chloride (2.24 g) + Proline (4.53 g) + Serine (3 g) + Sodium acetate trihydrate (1.5 g) + Sodium glycerophosphate (3.67 g) + Soybean oil (7 g) + Tyrosine (0.2 g)EmulsionIntravenousBaxter Laboratories2018-10-25Not applicableCanada
Periolimel 2.5% EOlive oil (24 g) + Aspartic acid (0.73 g) + Calcium Chloride (0.30 g) + Dextrose, unspecified form (82.50 g) + Glutamic Acid (1.26 g) + Glycine (1.76 g) + Histidine (1.51 g) + Isoleucine (1.26 g) + L-Alanine (3.66 g) + L-Arginine (2.48 g) + L-Leucine (1.76 g) + L-Lysine acetate (1.99 g) + L-Phenylalanine (1.76 g) + L-Threonine (1.26 g) + L-Tryptophan (0.42 g) + L-Valine (1.62 g) + Magnesium chloride (0.45 g) + Methionine (1.26 g) + Potassium chloride (1.19 g) + Proline (1.51 g) + Serine (1.0 g) + Sodium acetate trihydrate (1.16 g) + Sodium glycerophosphate (1.91 g) + Soybean oil (6 g) + Tyrosine (0.06 g)EmulsionIntravenousBaxter Laboratories2011-02-28Not applicableCanada
Unapproved/Other Products
NameIngredientsDosageRouteLabellerMarketing StartMarketing End
Intensive Treatment Bodyoil for Mommy To Be All SkinOlive oil (49.742 g/100mL)OilTopicalIn This Morning2018-12-11Not applicableUs
Rhodd Ato Repair Body So ApOlive oil (13.0 g/100g) + Chamaecyparis obtusa leaf (2.0 g/100g) + Evening primrose oil (6.0 g/100g)SoapTopicalSJ NATURAL2018-08-01Not applicableUs
Categories
UNII
6UYK2W1W1E
CAS number
8001-25-0
Weight
Not Available
Chemical Formula
Not Available
InChI Key
Not Available
InChI
Not Available
IUPAC Name
Not Available
SMILES
Not Available

Pharmacology

Indication

For use in adults as a source of calories and fatty acids in total parenteral nutrition Label. Sometimes used as an additive in cosmetic products.

Associated Therapies
Pharmacodynamics

Provides a source of calories and fatty acids Label.

Mechanism of action

Fatty acids act as a substrate in energy production through beta-oxidation as well as important components of cell membrane structures and prescursors for bioactive molecules like prostaglandins Label.

Additional Data Available
Adverse Effects

Comprehensive structured data on known drug adverse effects with statistical prevalence. MedDRA and ICD10 ids are provided for adverse effect conditions and symptoms.

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Additional Data Available
Contraindications

Structured data covering drug contraindications. Each contraindication describes a scenario in which the drug is not to be used. Includes restrictions on co-administration, contraindicated populations, and more.

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Additional Data Available
Blackbox Warnings

Structured data representing warnings from the black box section of drug labels. These warnings cover important and dangerous risks, contraindications, or adverse effects.

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Absorption
Not Available
Volume of distribution
Not Available
Protein binding
Not Available
Metabolism

Metabolized to carbon dioxide and water used as a substrate in energy production Label. Carbon dioxide is eliminated via expiration while water is eliminated through expiration, evaporation, and urination. Some lipids are excreted in bile.

Route of elimination
Not Available
Half life
Not Available
Clearance
Not Available
Toxicity

Fat overload sydrome is the primary form of toxicity characterized by a sudden deterioration in the patient's condition accompanied by fever, anemia, leukopenia, thrombocytopenia, coagulation disorders, hyperlipidemia, liver fatty infiltration, deteriorating liver function, and central nervous system manifestations such as coma Label. The precise cause of this is unclear. While it is most likely to occur during overdosage of lipids some occurences have been reported when lipids are administered appropriately. Intraperitoneal LD50 in mice of >50g/kg and intravenous LD50 in rats of 1320mg/kg 1.

Affected organisms
  • Humans and other mammals
Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
Not Available
Food Interactions
Not Available

References

General References
  1. ChemIDPlus: Olive Oil [Link]
External Links
PubChem Substance
347910464
Wikipedia
Olive_oil
FDA label
Download (304 KB)
MSDS
Download (47.3 KB)

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount
1CompletedTreatmentGlucose, High Blood / Lipid Disorders / Oxidative Stress / Type 2 Diabetes Mellitus1
1, 2CompletedSupportive CareCholestasis / Jaundice, Obstructive1
1, 2Not Yet RecruitingPreventionBMI >30 kg/m2 / Postmenopausal Women1
1, 2Not Yet RecruitingPreventionDynapenia / Postmenopausal Women1
1, 2RecruitingTreatmentSevere Sepsis / Shock, Septic1
1, 2Unknown StatusTreatmentSkin Inflammation1
2CompletedTreatmentCessation, Smoking / Pregnancy Related / Tobacco Use in Childbirth1
2CompletedTreatmentMania1
2TerminatedTreatmentAcute Respiratory Distress Syndrome (ARDS)1
2Unknown StatusTreatmentIntestinal Failure / Mucosal Enteropathy / Short Bowel Syndrome (SBS) / Upper gastrointestinal motility disorders1
2, 3CompletedTreatmentDry Eye Syndromes / Keratoconjunctivitis Sicca1
2, 3CompletedTreatmentFatty Acid Deficiency / Schizophrenic Disorders1
3CompletedPreventionCardiovascular Disease (CVD)1
3CompletedPreventionNonvalvular Atrial Fibrillation1
3CompletedPreventionRetinopathy of Prematurity1
3CompletedTreatmentCardiovascular Disease (CVD) / Hypertriglyceridemias1
3CompletedTreatmentDyslipidemia (Fredrickson Type Ⅱa)1
3CompletedTreatmentHypertriglyceridemias2
3CompletedTreatmentMyocardial Infarction1
3CompletedTreatmentParents2
3RecruitingPreventionCholestasis of Parenteral Nutrition1
3RecruitingSupportive CareHospitalized Neonates and Infants, Expected to Require Parenteral Nutrition for 28 Days1
3RecruitingTreatmentGeneral Surgery / Parenteral Feeding1
3RecruitingTreatmentGeneral Surgery / Parenteral Nutrition1
3RecruitingTreatmentTransplantation, Kidney1
4CompletedHealth Services ResearchSepsis Newborn1
4CompletedPreventionCholestasis / Psychomotor Disorders, Developmental1
4CompletedSupportive CareDietary and Nutritional Therapies1
4CompletedSupportive CareGastric Resection / Malnutrition1
4CompletedTreatmentDisorder Related to Renal Transplantation1
4CompletedTreatmentDry Eye Syndrome (DES) / Sjögren's Syndrome1
4CompletedTreatmentHepatic Function / Inflammatory Responses1
4CompletedTreatmentParenteral Nutrition1
4Not Yet RecruitingSupportive CareMalnutrition, Child1
4TerminatedTreatmentEssential Fatty Acid Deficiency (EFAD)1
4WithdrawnTreatmentHome Parenteral Nutrition / Short Bowel Syndrome (SBS)1
Not AvailableAvailableNot AvailableCholestasis / Growth Failure1
Not AvailableCompletedTreatmentIrritable Bowel Syndrome (IBS)1
Not AvailableCompletedTreatmentTourette's Disorder1
Not AvailableTerminatedTreatmentUrinary Bladder, Overactive1

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage forms
FormRouteStrength
EmulsionIntravenous
OilTopical49.742 g/100mL
SoapTopical
Injection, emulsionIntravenous
Prices
Not Available
Patents
Patent NumberPediatric ExtensionApprovedExpires (estimated)
US5840757No1998-11-242015-11-24Us
Additional Data Available
  • Filed On
    Filed On

    The date on which a patent was filed with the relevant government.

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Properties

State
Liquid
Experimental Properties
PropertyValueSource
water solubilityInsolubleMSDS
Predicted Properties
Not Available
Predicted ADMET features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
Not Available

Taxonomy

Classification
Not classified

Drug created on November 30, 2015 12:10 / Updated on June 04, 2019 07:13