Phenytoin Toxicity

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Iorga A, Horowitz BZ

Phenytoin Toxicity

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PubMed ID

29494051 [ View in PubMed

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Abstract

Since its discovery in 1908, phenytoin has become one of the most well-studied anticonvulsants. With an average monthly cost of $30, it has also become one of the most widely used anticonvulsants, listed on the World Health Organization's List of Essential Medicines. However, with its narrow therapeutic index and its pervasive daily use, considering potential phenytoin overdose or toxicity from chronic use is key to early management and prevention of further toxicity.[1][2][3]

DrugBank Data that Cites this Article

Drugs

Phenytoin

Drug Interactions

• Approved
• Vet approved
• Nutraceutical
• Illicit
• Withdrawn
• Investigational
• Experimental
• All Drugs

Drugs	Interaction
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Cyclosporine Phenytoin	The serum concentration of Cyclosporine can be decreased when it is combined with Phenytoin.
Cyclosporine Fosphenytoin	The serum concentration of Cyclosporine can be decreased when it is combined with Fosphenytoin.
Fosphenytoin Omeprazole	The serum concentration of Fosphenytoin can be increased when it is combined with Omeprazole.
Fosphenytoin Esomeprazole	The serum concentration of Fosphenytoin can be increased when it is combined with Esomeprazole.
Phenytoin Omeprazole	The serum concentration of Phenytoin can be increased when it is combined with Omeprazole.