Estrogen-related receptor gamma

Details

Name
Estrogen-related receptor gamma
Synonyms
  • ERR gamma-2
  • ERR3
  • ERRG2
  • Estrogen receptor-related protein 3
  • KIAA0832
  • NR3B3
  • Nuclear receptor subfamily 3 group B member 3
Gene Name
ESRRG
Organism
Humans
Amino acid sequence
>lcl|BSEQ0004094|Estrogen-related receptor gamma
MDSVELCLPESFSLHYEEELLCRMSNKDRHIDSSCSSFIKTEPSSPASLTDSVNHHSPGG
SSDASGSYSSTMNGHQNGLDSPPLYPSAPILGGSGPVRKLYDDCSSTIVEDPQTKCEYML
NSMPKRLCLVCGDIASGYHYGVASCEACKAFFKRTIQGNIEYSCPATNECEITKRRRKSC
QACRFMKCLKVGMLKEGVRLDRVRGGRQKYKRRIDAENSPYLNPQLVQPAKKPYNKIVSH
LLVAEPEKIYAMPDPTVPDSDIKALTTLCDLADRELVVIIGWAKHIPGFSTLSLADQMSL
LQSAWMEILILGVVYRSLSFEDELVYADDYIMDEDQSKLAGLLDLNNAILQLVKKYKSMK
LEKEEFVTLKAIALANSDSMHIEDVEAVQKLQDVLHEALQDYEAGQHMEDPRRAGKMLMT
LPLLRQTSTKAVQHFYNIKLEGKVPMHKLFLEMLEAKV
Number of residues
458
Molecular Weight
51305.485
Theoretical pI
6.44
GO Classification
Functions
AF-2 domain binding / retinoic acid receptor activity / RNA polymerase II regulatory region sequence-specific DNA binding / steroid binding / steroid hormone receptor activity / transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding / zinc ion binding
Processes
gene expression / positive regulation of transcription, DNA-templated / regulation of transcription, DNA-templated / transcription initiation from RNA polymerase II promoter
Components
nucleoplasm
General Function
Zinc ion binding
Specific Function
Orphan receptor that acts as transcription activator in the absence of bound ligand. Binds specifically to an estrogen response element and activates reporter genes controlled by estrogen response elements (By similarity). Induces the expression of PERM1 in the skeletal muscle.
Pfam Domain Function
Transmembrane Regions
Not Available
Cellular Location
Nucleus
Gene sequence
>lcl|BSEQ0016674|Estrogen-related receptor gamma (ESRRG)
ATGTCAAACAAAGATCGACACATTGATTCCAGCTGTTCGTCCTTCATCAAGACGGAACCT
TCCAGCCCAGCCTCCCTGACGGACAGCGTCAACCACCACAGCCCTGGTGGCTCTTCAGAC
GCCAGTGGGAGCTACAGTTCAACCATGAATGGCCATCAGAACGGACTTGACTCGCCACCT
CTCTACCCTTCTGCTCCTATCCTGGGAGGTAGTGGGCCTGTCAGGAAACTGTATGATGAC
TGCTCCAGCACCATTGTTGAAGATCCCCAGACCAAGTGTGAATACATGCTCAACTCGATG
CCCAAGAGACTGTGTTTAGTGTGTGGTGACATCGCTTCTGGGTACCACTATGGGGTAGCA
TCATGTGAAGCCTGCAAGGCATTCTTCAAGAGGACAATTCAAGGCAATATAGAATACAGC
TGCCCTGCCACGAATGAATGTGAAATCACAAAGCGCAGACGTAAATCCTGCCAGGCTTGC
CGCTTCATGAAGTGTTTAAAAGTGGGCATGCTGAAAGAAGGGGTGCGTCTTGACAGAGTA
CGTGGAGGTCGGCAGAAGTACAAGCGCAGGATAGATGCGGAGAACAGCCCATACCTGAAC
CCTCAGCTGGTTCAGCCAGCCAAAAAGCCATATAACAAGATTGTCTCACATTTGTTGGTG
GCTGAACCGGAGAAGATCTATGCCATGCCTGACCCTACTGTCCCCGACAGTGACATCAAA
GCCCTCACTACACTGTGTGACTTGGCCGACCGAGAGTTGGTGGTTATCATTGGATGGGCG
AAGCATATTCCAGGCTTCTCCACGCTGTCCCTGGCGGACCAGATGAGCCTTCTGCAGAGT
GCTTGGATGGAAATTTTGATCCTTGGTGTCGTATACCGGTCTCTTTCGTTTGAGGATGAA
CTTGTCTATGCAGACGATTATATAATGGACGAAGACCAGTCCAAATTAGCAGGCCTTCTT
GATCTAAATAATGCTATCCTGCAGCTGGTAAAGAAATACAAGAGCATGAAGCTGGAAAAA
GAAGAATTTGTCACCCTCAAAGCTATAGCTCTTGCTAATTCAGACTCCATGCACATAGAA
GATGTTGAAGCCGTTCAGAAGCTTCAGGATGTCTTACATGAAGCGCTGCAGGATTATGAA
GCTGGCCAGCACATGGAAGACCCTCGTCGAGCTGGCAAGATGCTGATGACACTGCCACTC
CTGAGGCAGACCTCTACCAAGGCCGTGCAGCATTTCTACAACATCAAACTAGAAGGCAAA
GTCCCAATGCACAAACTTTTTTTGGAAATGTTGGAGGCCAAGGTCTGA
Chromosome Location
1
Locus
1q41
External Identifiers
ResourceLink
UniProtKB IDP62508
UniProtKB Entry NameERR3_HUMAN
GenBank Protein ID4092075
GenBank Gene IDAF094518
GenAtlas IDESRRG
HGNC IDHGNC:3474
General References
  1. Chen F, Zhang Q, McDonald T, Davidoff MJ, Bailey W, Bai C, Liu Q, Caskey CT: Identification of two hERR2-related novel nuclear receptors utilizing bioinformatics and inverse PCR. Gene. 1999 Mar 4;228(1-2):101-9. [Article]
  2. Nagase T, Ishikawa K, Suyama M, Kikuno R, Hirosawa M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O: Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. DNA Res. 1998 Dec 31;5(6):355-64. [Article]
  3. Eudy JD, Yao S, Weston MD, Ma-Edmonds M, Talmadge CB, Cheng JJ, Kimberling WJ, Sumegi J: Isolation of a gene encoding a novel member of the nuclear receptor superfamily from the critical region of Usher syndrome type IIa at 1q41. Genomics. 1998 Jun 15;50(3):382-4. [Article]
  4. Heard DJ, Norby PL, Holloway J, Vissing H: Human ERRgamma, a third member of the estrogen receptor-related receptor (ERR) subfamily of orphan nuclear receptors: tissue-specific isoforms are expressed during development and in the adult. Mol Endocrinol. 2000 Mar;14(3):382-92. [Article]
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  12. Hentschke M, Susens U, Borgmeyer U: Transcriptional ERRgamma2-mediated activation is regulated by sentrin-specific proteases. Biochem J. 2009 Apr 1;419(1):167-76. doi: 10.1042/BJ20081556. [Article]
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  15. Cho Y, Hazen BC, Russell AP, Kralli A: Peroxisome proliferator-activated receptor gamma coactivator 1 (PGC-1)- and estrogen-related receptor (ERR)-induced regulator in muscle 1 (Perm1) is a tissue-specific regulator of oxidative capacity in skeletal muscle cells. J Biol Chem. 2013 Aug 30;288(35):25207-18. doi: 10.1074/jbc.M113.489674. Epub 2013 Jul 8. [Article]
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Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails
DB00255Diethylstilbestrolapproved, investigational, withdrawnyesagonistDetails
DB04468AfimoxifeneinvestigationalunknownDetails
DB00197Troglitazoneapproved, investigational, withdrawnnoinverse agonistDetails
DB068844-HYDROXY-N'-(4-ISOPROPYLBENZYL)BENZOHYDRAZIDEexperimentalunknownDetails
DB06902p-CumylphenolexperimentalunknownDetails
DB06973Bisphenol AexperimentalunknownDetails
DB07485Bisphenol ZexperimentalunknownDetails
DB02659Cholic AcidapprovedunknownDetails
DB00675TamoxifenapprovedunknownDetails
DB13952Estradiol acetateapproved, investigational, vet_approvedunknownligandDetails
DB13953Estradiol benzoateapproved, investigational, vet_approvedunknownligandDetails
DB13954Estradiol cypionateapproved, investigational, vet_approvedunknownligandDetails
DB13955Estradiol dienanthateapproved, investigational, vet_approvedunknownligandDetails
DB13956Estradiol valerateapproved, investigational, vet_approvedunknownligandDetails