You are using an unsupported browser. Please upgrade your browser to a newer version to get the best experience on DrugBank.
Identification
NamePregabalin
Accession NumberDB00230  (APRD01198)
TypeSmall Molecule
GroupsApproved, Illicit, Investigational
DescriptionPregabalin is an anticonvulsant drug used for neuropathic pain, as an adjunct therapy for partial seizures, and in generalized anxiety disorder. It was designed as a more potent successor to gabapentin. Pregabalin is marketed by Pfizer under the trade name Lyrica. It is considered to have a dependence liability if misused, and is classified as a Schedule V drug in the U.S. [Wikipedia]
Structure
Thumb
Synonyms
(S)-3-Isobutyl gaba
3-Isobutyl gaba
CI-1008
Lyrica
S-(+)-3-isobutylgaba
External Identifiers Not Available
Approved Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Ach-pregabalincapsule100 mgoralAccord Healthcare IncNot applicableNot applicableCanada
Ach-pregabalincapsule300 mgoralAccord Healthcare IncNot applicableNot applicableCanada
Ach-pregabalincapsule25 mgoralAccord Healthcare IncNot applicableNot applicableCanada
Ach-pregabalincapsule150 mgoralAccord Healthcare IncNot applicableNot applicableCanada
Ach-pregabalincapsule50 mgoralAccord Healthcare IncNot applicableNot applicableCanada
Ach-pregabalincapsule200 mgoralAccord Healthcare IncNot applicableNot applicableCanada
Ach-pregabalincapsule75 mgoralAccord Healthcare IncNot applicableNot applicableCanada
Ach-pregabalincapsule225 mgoralAccord Healthcare IncNot applicableNot applicableCanada
Act Pregabalincapsule100 mgoralActavis Pharma CompanyNot applicableNot applicableCanada
Act Pregabalincapsule75 mgoralActavis Pharma Company2013-03-06Not applicableCanada
Act Pregabalincapsule200 mgoralActavis Pharma CompanyNot applicableNot applicableCanada
Act Pregabalincapsule150 mgoralActavis Pharma Company2013-03-06Not applicableCanada
Act Pregabalincapsule25 mgoralActavis Pharma Company2013-03-06Not applicableCanada
Act Pregabalincapsule225 mgoralActavis Pharma Company2013-03-06Not applicableCanada
Act Pregabalincapsule50 mgoralActavis Pharma Company2013-03-06Not applicableCanada
Act Pregabalincapsule300 mgoralActavis Pharma Company2013-03-06Not applicableCanada
Auro-pregabalincapsule300 mgoralAuro Pharma IncNot applicableNot applicableCanada
Auro-pregabalincapsule150 mgoralAuro Pharma Inc2015-03-02Not applicableCanada
Auro-pregabalincapsule100 mgoralAuro Pharma IncNot applicableNot applicableCanada
Auro-pregabalincapsule25 mgoralAuro Pharma Inc2015-03-02Not applicableCanada
Auro-pregabalincapsule200 mgoralAuro Pharma IncNot applicableNot applicableCanada
Auro-pregabalincapsule50 mgoralAuro Pharma Inc2015-03-02Not applicableCanada
Auro-pregabalincapsule225 mgoralAuro Pharma IncNot applicableNot applicableCanada
Auro-pregabalincapsule75 mgoralAuro Pharma Inc2015-03-02Not applicableCanada
Dom-pregabalincapsule75 mgoralDominion Pharmacal2013-09-09Not applicableCanada
Dom-pregabalincapsule300 mgoralDominion PharmacalNot applicableNot applicableCanada
Dom-pregabalincapsule150 mgoralDominion Pharmacal2013-09-09Not applicableCanada
Dom-pregabalincapsule25 mgoralDominion Pharmacal2013-09-09Not applicableCanada
Dom-pregabalincapsule225 mgoralDominion PharmacalNot applicableNot applicableCanada
Dom-pregabalincapsule50 mgoralDominion Pharmacal2013-09-09Not applicableCanada
Gd-pregabalincapsule300 mgoralGenmed A Division Of Pfizer Canada Inc2013-02-152015-09-01Canada
Gd-pregabalincapsule50 mgoralGenmed A Division Of Pfizer Canada Inc2013-02-152015-09-01Canada
Gd-pregabalincapsule75 mgoralGenmed A Division Of Pfizer Canada Inc2013-02-152015-09-30Canada
Gd-pregabalincapsule150 mgoralGenmed A Division Of Pfizer Canada Inc2013-02-152015-09-30Canada
Gd-pregabalincapsule25 mgoralGenmed A Division Of Pfizer Canada Inc2013-02-152015-09-01Canada
Gd-pregabalincapsule225 mgoralGenmed A Division Of Pfizer Canada Inc2013-02-152015-09-30Canada
Ipg-pregabalincapsule150 mgoralMarcan Pharmaceuticals IncNot applicableNot applicableCanada
Ipg-pregabalincapsule25 mgoralMarcan Pharmaceuticals IncNot applicableNot applicableCanada
Ipg-pregabalincapsule200 mgoralMarcan Pharmaceuticals IncNot applicableNot applicableCanada
Ipg-pregabalincapsule50 mgoralMarcan Pharmaceuticals IncNot applicableNot applicableCanada
Ipg-pregabalincapsule225 mgoralMarcan Pharmaceuticals IncNot applicableNot applicableCanada
Ipg-pregabalincapsule75 mgoralMarcan Pharmaceuticals IncNot applicableNot applicableCanada
Ipg-pregabalincapsule300 mgoralMarcan Pharmaceuticals IncNot applicableNot applicableCanada
Ipg-pregabalincapsule100 mgoralMarcan Pharmaceuticals IncNot applicableNot applicableCanada
Jamp-pregabalincapsule25 mgoralJamp Pharma Corporation2015-09-28Not applicableCanada
Jamp-pregabalincapsule300 mgoralJamp Pharma Corporation2015-09-28Not applicableCanada
Jamp-pregabalincapsule50 mgoralJamp Pharma Corporation2015-09-28Not applicableCanada
Jamp-pregabalincapsule75 mgoralJamp Pharma Corporation2015-09-28Not applicableCanada
Jamp-pregabalincapsule150 mgoralJamp Pharma Corporation2015-09-28Not applicableCanada
Lyricacapsule150 mg/1oralH.J. Harkins Company, Inc.2004-12-30Not applicableUs
Lyricacapsule225 mg/1oralParke Davis Div Of Pfizer Inc2004-12-30Not applicableUs
Lyricacapsule100 mg/1oralPd Rx Pharmaceuticals, Inc.2004-12-30Not applicableUs
Lyricacapsule200 mg/1oralbryant ranch prepack2004-12-30Not applicableUs
Lyricacapsule50 mg/1oralSTAT Rx USA LLC2004-12-30Not applicableUs
Lyricacapsule100 mg/1oralA S Medication Solutions Llc2004-12-30Not applicableUs
Lyricacapsule100 mg/1oralUnit Dose Services2004-12-30Not applicableUs
Lyricacapsule25 mg/1oralParke Davis Div Of Pfizer Inc2004-12-30Not applicableUs
Lyricacapsule25 mg/1oralPhysicians Total Care, Inc.2006-08-29Not applicableUs
Lyricacapsule100 mg/1oralDIRECT RX2015-01-01Not applicableUs
Lyricacapsule200 mg/1oralRebel Distributors Corp2005-06-10Not applicableUs
Lyricacapsule225 mgoralPfizer Canada Inc2009-11-18Not applicableCanada
Lyricacapsule75 mg/1oralLake Erie Medical DBA Quality Care Products LLC2011-02-10Not applicableUs
Lyricacapsule75 mg/1oralA S Medication Solutions2004-12-30Not applicableUs
Lyricacapsule75 mg/1oralA S Medication Solutions Llc2004-12-30Not applicableUs
Lyricacapsule50 mg/1oralRebel Distributors Corp2005-06-10Not applicableUs
Lyricacapsule200 mg/1oralSt Marys Medical Park Pharmacy2010-12-31Not applicableUs
Lyricacapsule25 mgoralPfizer Canada Inc2005-07-18Not applicableCanada
Lyricacapsule150 mg/1oralAphena Pharma Solutions Tennessee, Llc2004-12-30Not applicableUs
Lyricacapsule50 mg/1oralUnit Dose Services2004-12-30Not applicableUs
Lyricacapsule100 mg/1oralH.J. Harkins Company, Inc.2004-12-30Not applicableUs
Lyricacapsule150 mg/1oralParke Davis Div Of Pfizer Inc2004-12-30Not applicableUs
Lyricacapsule100 mg/1oralCardinal Health2004-12-30Not applicableUs
Lyricacapsule100 mg/1oralbryant ranch prepack2004-12-30Not applicableUs
Lyricacapsule300 mg/1oralLake Erie Medical DBA Quality Care Products LLC2010-08-13Not applicableUs
Lyricacapsule75 mg/1oralA S Medication Solutions Llc2004-12-30Not applicableUs
Lyricacapsule50 mg/1oralA S Medication Solutions Llc2004-12-30Not applicableUs
Lyricasolution20 mg/mLoralParke Davis Div Of Pfizer Inc2004-12-30Not applicableUs
Lyricacapsule75 mg/1oralPd Rx Pharmaceuticals, Inc.2004-12-30Not applicableUs
Lyricacapsule300 mg/1oralbryant ranch prepack2004-12-30Not applicableUs
Lyricacapsule50 mg/1oralAphena Pharma Solutions Tennessee, Llc2004-12-30Not applicableUs
Lyricacapsule100 mg/1oralA S Medication Solutions Llc2004-12-30Not applicableUs
Lyricacapsule150 mg/1oralUnit Dose Services2004-12-30Not applicableUs
Lyricacapsule50 mg/1oralParke Davis Div Of Pfizer Inc2004-12-30Not applicableUs
Lyricacapsule25 mg/1oralCardinal Health2004-12-30Not applicableUs
Lyricacapsule50 mg/1oralU.S. Pharmaceuticals2004-12-30Not applicableUs
Lyricacapsule300 mg/1oralRebel Distributors Corp2004-12-30Not applicableUs
Lyricacapsule300 mgoralPfizer Canada Inc2005-07-18Not applicableCanada
Lyricacapsule100 mg/1oralLake Erie Medical & Surgical Supply DBA Quality Care Products LLC2012-02-06Not applicableUs
Lyricacapsule100 mgoralPfizer Canada IncNot applicableNot applicableCanada
Lyricacapsule50 mg/1oralA S Medication Solutions2004-12-30Not applicableUs
Lyricacapsule150 mg/1oralPhysicians Total Care, Inc.2005-10-19Not applicableUs
Lyricacapsule75 mg/1oralRebel Distributors Corp2005-06-10Not applicableUs
Lyricacapsule100 mg/1oralSt Marys Medical Park Pharmacy2010-12-31Not applicableUs
Lyricacapsule50 mgoralPfizer Canada Inc2005-07-18Not applicableCanada
Lyricacapsule200 mg/1oralAphena Pharma Solutions Tennessee, Llc2004-12-30Not applicableUs
Lyricacapsule75 mg/1oralUnit Dose Services2004-12-30Not applicableUs
Lyricacapsule75 mg/1oralH.J. Harkins Company, Inc.2004-12-30Not applicableUs
Lyricacapsule200 mg/1oralParke Davis Div Of Pfizer Inc2004-12-30Not applicableUs
Lyricacapsule150 mg/1oralPd Rx Pharmaceuticals, Inc.2004-12-30Not applicableUs
Lyricacapsule150 mg/1oralbryant ranch prepack2004-12-30Not applicableUs
Lyricacapsule225 mg/1oralRebel Distributors Corp2004-12-30Not applicableUs
Lyricacapsule50 mg/1oralA S Medication Solutions Llc2004-12-30Not applicableUs
Lyricacapsule100 mg/1oralA S Medication Solutions Llc2004-12-30Not applicableUs
Lyricacapsule50 mg/1oralSTAT Rx USA LLC2004-12-30Not applicableUs
Lyricacapsule50 mg/1oralPd Rx Pharmaceuticals, Inc.2004-12-30Not applicableUs
Lyricacapsule150 mg/1oralDispensing Solutions, Inc.2004-12-30Not applicableUs
Lyricacapsule75 mg/1oralAphena Pharma Solutions Tennessee, Llc2004-12-30Not applicableUs
Lyricacapsule150 mg/1oralA S Medication Solutions Llc2004-12-30Not applicableUs
Lyricacapsule200 mg/1oralUnit Dose Services2004-12-30Not applicableUs
Lyricacapsule75 mg/1oralParke Davis Div Of Pfizer Inc2004-12-30Not applicableUs
Lyricacapsule50 mg/1oralCardinal Health2004-12-30Not applicableUs
Lyricacapsule75 mg/1oralU.S. Pharmaceuticals2004-12-30Not applicableUs
Lyricacapsule25 mg/1oralLake Erie Medical & Surgical Supply DBA Quality Care Products LLC2011-07-18Not applicableUs
Lyricacapsule200 mg/1oralLake Erie Medical DBA Quality Care Products LLC2010-09-27Not applicableUs
Lyricacapsule200 mgoralPfizer Canada IncNot applicableNot applicableCanada
Lyricacapsule100 mg/1oralA S Medication Solutions2004-12-30Not applicableUs
Lyricacapsule50 mg/1oralPhysicians Total Care, Inc.2005-12-20Not applicableUs
Lyricacapsule100 mg/1oralRebel Distributors Corp2005-06-10Not applicableUs
Lyricacapsule75 mgoralPfizer Canada Inc2005-07-18Not applicableCanada
Lyricacapsule300 mg/1oralAphena Pharma Solutions Tennessee, Llc2004-12-30Not applicableUs
Lyricacapsule300 mg/1oralUnit Dose Services2004-12-30Not applicableUs
Lyricacapsule75 mg/1oralSTAT Rx USA LLC2004-12-30Not applicableUs
Lyricacapsule50 mg/1oralA S Medication Solutions Llc2004-12-30Not applicableUs
Lyricacapsule50 mg/1oralH.J. Harkins Company, Inc.2004-12-30Not applicableUs
Lyricacapsule300 mg/1oralParke Davis Div Of Pfizer Inc2004-12-30Not applicableUs
Lyricacapsule300 mg/1oralPd Rx Pharmaceuticals, Inc.2004-12-30Not applicableUs
Lyricacapsule25 mg/1oralbryant ranch prepack2004-12-30Not applicableUs
Lyricacapsule150 mg/1oralA S Medication Solutions Llc2004-12-30Not applicableUs
Lyricacapsule25 mg/1oralRebel Distributors Corp2005-06-10Not applicableUs
Lyricacapsule150 mg/1oralSt Marys Medical Park Pharmacy2010-12-31Not applicableUs
Lyricacapsule75 mg/1oralDispensing Solutions, Inc.2004-12-30Not applicableUs
Lyricacapsule100 mg/1oralAphena Pharma Solutions Tennessee, Llc2004-12-30Not applicableUs
Lyricacapsule150 mg/1oralA S Medication Solutions Llc2004-12-30Not applicableUs
Lyricacapsule150 mg/1oralREMEDYREPACK INC.2013-06-03Not applicableUs
Lyricacapsule100 mg/1oralParke Davis Div Of Pfizer Inc2004-12-30Not applicableUs
Lyricacapsule75 mg/1oralCardinal Health2004-12-30Not applicableUs
Lyricacapsule50 mg/1oralbryant ranch prepack2004-12-30Not applicableUs
Lyricacapsule150 mg/1oralLake Erie Medical & Surgical Supply DBA Quality Care Products LLC2012-02-06Not applicableUs
Lyricacapsule50 mg/1oralLake Erie Medical & Surgical Supply, DBA Quality Care Products, LLC2011-11-08Not applicableUs
Lyricacapsule150 mgoralPfizer Canada Inc2005-07-18Not applicableCanada
Lyricacapsule225 mg/1oralAphena Pharma Solutions Tennessee, Llc2004-12-30Not applicableUs
Lyricacapsule25 mg/1oralUnit Dose Services2004-12-30Not applicableUs
Lyricacapsule150 mg/1oralA S Medication Solutions2004-12-30Not applicableUs
Lyricacapsule75 mg/1oralPhysicians Total Care, Inc.2006-11-01Not applicableUs
Lyricacapsule150 mg/1oralRebel Distributors Corp2005-06-10Not applicableUs
Lyricacapsule75 mg/1oralDIRECT RX2014-01-01Not applicableUs
Mar-pregabalincapsule150 mgoralMarcan Pharmaceuticals Inc2014-11-26Not applicableCanada
Mar-pregabalincapsule225 mgoralMarcan Pharmaceuticals IncNot applicableNot applicableCanada
Mar-pregabalincapsule25 mgoralMarcan Pharmaceuticals Inc2014-11-26Not applicableCanada
Mar-pregabalincapsule300 mgoralMarcan Pharmaceuticals IncNot applicableNot applicableCanada
Mar-pregabalincapsule50 mgoralMarcan Pharmaceuticals Inc2014-11-26Not applicableCanada
Mar-pregabalincapsule100 mgoralMarcan Pharmaceuticals IncNot applicableNot applicableCanada
Mar-pregabalincapsule75 mgoralMarcan Pharmaceuticals Inc2014-11-26Not applicableCanada
Mar-pregabalincapsule200 mgoralMarcan Pharmaceuticals IncNot applicableNot applicableCanada
Mint-pregabalincapsule225 mgoralMint Pharmaceuticals IncNot applicableNot applicableCanada
Mint-pregabalincapsule75 mgoralMint Pharmaceuticals Inc2014-06-12Not applicableCanada
Mint-pregabalincapsule300 mgoralMint Pharmaceuticals IncNot applicableNot applicableCanada
Mint-pregabalincapsule150 mgoralMint Pharmaceuticals Inc2014-06-12Not applicableCanada
Mint-pregabalincapsule25 mgoralMint Pharmaceuticals Inc2014-06-12Not applicableCanada
Mint-pregabalincapsule100 mgoralMint Pharmaceuticals IncNot applicableNot applicableCanada
Mint-pregabalincapsule50 mgoralMint Pharmaceuticals Inc2014-06-12Not applicableCanada
Mint-pregabalincapsule200 mgoralMint Pharmaceuticals IncNot applicableNot applicableCanada
Myl-pregabalincapsule25 mgoralMylan Pharmaceuticals Ulc2013-07-242016-05-20Canada
Myl-pregabalincapsule300 mgoralMylan Pharmaceuticals Ulc2013-07-242016-05-20Canada
Myl-pregabalincapsule50 mgoralMylan Pharmaceuticals Ulc2013-07-142016-05-20Canada
Myl-pregabalincapsule225 mgoralMylan Pharmaceuticals UlcNot applicableNot applicableCanada
Myl-pregabalincapsule75 mgoralMylan Pharmaceuticals Ulc2013-07-242016-05-20Canada
Myl-pregabalincapsule150 mgoralMylan Pharmaceuticals Ulc2013-07-242016-05-20Canada
Mylan-pregabalincapsule225 mgoralMylan Pharmaceuticals UlcNot applicableNot applicableCanada
Mylan-pregabalincapsule50 mgoralMylan Pharmaceuticals UlcNot applicableNot applicableCanada
Mylan-pregabalincapsule75 mgoralMylan Pharmaceuticals UlcNot applicableNot applicableCanada
Mylan-pregabalincapsule150 mgoralMylan Pharmaceuticals UlcNot applicableNot applicableCanada
Mylan-pregabalincapsule300 mgoralMylan Pharmaceuticals UlcNot applicableNot applicableCanada
Mylan-pregabalincapsule25 mgoralMylan Pharmaceuticals UlcNot applicableNot applicableCanada
Pendo-pregabalincapsule50 mgoralPendopharm Division Of De Pharmascience IncNot applicableNot applicableCanada
Pendo-pregabalincapsule150 mgoralPendopharm Division Of De Pharmascience IncNot applicableNot applicableCanada
PMS-pregabalincapsule75 mgoralPharmascience Inc2013-02-14Not applicableCanada
PMS-pregabalincapsule225 mgoralPharmascience Inc2013-02-19Not applicableCanada
PMS-pregabalincapsule150 mgoralPharmascience Inc2013-02-14Not applicableCanada
PMS-pregabalincapsule25 mgoralPharmascience Inc2013-02-14Not applicableCanada
PMS-pregabalincapsule300 mgoralPharmascience Inc2013-02-14Not applicableCanada
PMS-pregabalincapsule50 mgoralPharmascience Inc2013-02-14Not applicableCanada
Pregabalincapsule225 mgoralAlembic Pharmaceuticals LimitedNot applicableNot applicableCanada
Pregabalincapsule50 mgoralLaboratoire Riva IncNot applicableNot applicableCanada
Pregabalincapsule50 mgoralSanis Health Inc2013-06-12Not applicableCanada
Pregabalincapsule50 mgoralPro Doc Limitee2013-02-15Not applicableCanada
Pregabalincapsule300 mgoralRanbaxy Pharmaceuticals Canada Inc.Not applicableNot applicableCanada
Pregabalincapsule225 mgoralActavis Pharma CompanyNot applicableNot applicableCanada
Pregabalincapsule75 mgoralActavis Pharma CompanyNot applicableNot applicableCanada
Pregabalincapsule75 mgoralSivem Pharmaceuticals Ulc2013-03-27Not applicableCanada
Pregabalincapsule50 mgoralRanbaxy Pharmaceuticals Canada Inc.Not applicableNot applicableCanada
Pregabalincapsule100 mgoralAlembic Pharmaceuticals LimitedNot applicableNot applicableCanada
Pregabalincapsule75 mgoralLaboratoire Riva IncNot applicableNot applicableCanada
Pregabalincapsule75 mgoralSanis Health Inc2013-06-12Not applicableCanada
Pregabalincapsule300 mgoralAlembic Pharmaceuticals LimitedNot applicableNot applicableCanada
Pregabalincapsule300 mgoralActavis Pharma CompanyNot applicableNot applicableCanada
Pregabalincapsule75 mgoralPro Doc Limitee2013-02-15Not applicableCanada
Pregabalincapsule25 mgoralAlembic Pharmaceuticals LimitedNot applicableNot applicableCanada
Pregabalincapsule75 mgoralRanbaxy Pharmaceuticals Canada Inc.Not applicableNot applicableCanada
Pregabalincapsule100 mgoralActavis Pharma CompanyNot applicableNot applicableCanada
Pregabalincapsule150 mgoralSivem Pharmaceuticals Ulc2013-03-27Not applicableCanada
Pregabalincapsule150 mgoralAlembic Pharmaceuticals LimitedNot applicableNot applicableCanada
Pregabalincapsule25 mgoralActavis Pharma CompanyNot applicableNot applicableCanada
Pregabalincapsule150 mgoralLaboratoire Riva IncNot applicableNot applicableCanada
Pregabalincapsule150 mgoralSanis Health Inc2013-06-12Not applicableCanada
Pregabalincapsule25 mgoralSivem Pharmaceuticals Ulc2013-03-27Not applicableCanada
Pregabalincapsule150 mgoralPro Doc Limitee2013-02-15Not applicableCanada
Pregabalincapsule50 mgoralAlembic Pharmaceuticals LimitedNot applicableNot applicableCanada
Pregabalincapsule300 mgoralSivem Pharmaceuticals Ulc2013-03-27Not applicableCanada
Pregabalincapsule150 mgoralRanbaxy Pharmaceuticals Canada Inc.Not applicableNot applicableCanada
Pregabalincapsule150 mgoralActavis Pharma CompanyNot applicableNot applicableCanada
Pregabalincapsule50 mg/1oralDIRECT RX2014-01-01Not applicableUs
Pregabalincapsule200 mgoralAlembic Pharmaceuticals LimitedNot applicableNot applicableCanada
Pregabalincapsule225 mgoralSanis Health IncNot applicableNot applicableCanada
Pregabalincapsule25 mgoralLaboratoire Riva IncNot applicableNot applicableCanada
Pregabalincapsule25 mgoralSanis Health Inc2013-06-12Not applicableCanada
Pregabalincapsule50 mgoralActavis Pharma CompanyNot applicableNot applicableCanada
Pregabalincapsule300 mgoralLaboratoire Riva IncNot applicableNot applicableCanada
Pregabalincapsule300 mgoralSanis Health Inc2013-06-12Not applicableCanada
Pregabalincapsule50 mgoralSivem Pharmaceuticals Ulc2013-03-27Not applicableCanada
Pregabalincapsule25 mgoralRanbaxy Pharmaceuticals Canada Inc.Not applicableNot applicableCanada
Pregabalincapsule300 mgoralPro Doc Limitee2013-02-15Not applicableCanada
Pregabalincapsule75 mgoralAlembic Pharmaceuticals LimitedNot applicableNot applicableCanada
Pregabalincapsule25 mgoralPro Doc Limitee2013-02-15Not applicableCanada
Pregabalincapsule225 mgoralSivem Pharmaceuticals Ulc2013-03-27Not applicableCanada
Pregabalincapsule225 mgoralRanbaxy Pharmaceuticals Canada Inc.Not applicableNot applicableCanada
Pregabalincapsule200 mgoralActavis Pharma CompanyNot applicableNot applicableCanada
Pregabalin Capsulescapsule225 mgoralLUPIN LIMITEDNot applicableNot applicableCanada
Pregabalin Capsulescapsule100 mgoralLUPIN LIMITEDNot applicableNot applicableCanada
Pregabalin Capsulescapsule300 mgoralLUPIN LIMITEDNot applicableNot applicableCanada
Pregabalin Capsulescapsule25 mgoralLUPIN LIMITEDNot applicableNot applicableCanada
Pregabalin Capsulescapsule150 mgoralLUPIN LIMITEDNot applicableNot applicableCanada
Pregabalin Capsulescapsule50 mgoralLUPIN LIMITEDNot applicableNot applicableCanada
Pregabalin Capsulescapsule200 mgoralLUPIN LIMITEDNot applicableNot applicableCanada
Pregabalin Capsulescapsule75 mgoralLUPIN LIMITEDNot applicableNot applicableCanada
Pregabalin PfizerCapsule, hard50 mgOral usePfizer Limited2014-04-10Not applicableEu
Pregabalin PfizerCapsule, hard150 mgOral usePfizer Limited2014-04-10Not applicableEu
Pregabalin PfizerCapsule, hard300 mgOral usePfizer Limited2014-04-10Not applicableEu
Pregabalin PfizerCapsule, hard25 mgOral usePfizer Limited2014-04-10Not applicableEu
Pregabalin PfizerCapsule, hard75 mgOral usePfizer Limited2014-04-10Not applicableEu
Pregabalin PfizerCapsule, hard225 mgOral usePfizer Limited2014-04-10Not applicableEu
Pregabalin PfizerCapsule, hard75 mgOral usePfizer Limited2014-04-10Not applicableEu
Pregabalin PfizerCapsule, hard200 mgOral usePfizer Limited2014-04-10Not applicableEu
Pregabalin PfizerCapsule, hard50 mgOral usePfizer Limited2014-04-10Not applicableEu
Pregabalin PfizerCapsule, hard100 mgOral usePfizer Limited2014-04-10Not applicableEu
Pregabalin PfizerCapsule, hard300 mgOral usePfizer Limited2014-04-10Not applicableEu
Pregabalin PfizerCapsule, hard50 mgOral usePfizer Limited2014-04-10Not applicableEu
Pregabalin PfizerCapsule, hard150 mgOral usePfizer Limited2014-04-10Not applicableEu
Pregabalin PfizerCapsule, hard300 mgOral usePfizer Limited2014-04-10Not applicableEu
Pregabalin PfizerCapsule, hard25 mgOral usePfizer Limited2014-04-10Not applicableEu
Pregabalin PfizerCapsule, hard100 mgOral usePfizer Limited2014-04-10Not applicableEu
Pregabalin PfizerCapsule, hard225 mgOral usePfizer Limited2014-04-10Not applicableEu
Pregabalin PfizerCapsule, hard25 mgOral usePfizer Limited2014-04-10Not applicableEu
Pregabalin PfizerCapsule, hard75 mgOral usePfizer Limited2014-04-10Not applicableEu
Pregabalin PfizerCapsule, hard200 mgOral usePfizer Limited2014-04-10Not applicableEu
Pregabalin PfizerCapsule, hard50 mgOral usePfizer Limited2014-04-10Not applicableEu
Pregabalin PfizerCapsule, hard150 mgOral usePfizer Limited2014-04-10Not applicableEu
Pregabalin PfizerCapsule, hard300 mgOral usePfizer Limited2014-04-10Not applicableEu
Pregabalin PfizerCapsule, hard50 mgOral usePfizer Limited2014-04-10Not applicableEu
Pregabalin PfizerCapsule, hard150 mgOral usePfizer Limited2014-04-10Not applicableEu
Pregabalin PfizerCapsule, hard300 mgOral usePfizer Limited2014-04-10Not applicableEu
Pregabalin PfizerCapsule, hard25 mgOral usePfizer Limited2014-04-10Not applicableEu
Pregabalin PfizerCapsule, hard100 mgOral usePfizer Limited2014-04-10Not applicableEu
Pregabalin PfizerCapsule, hard225 mgOral usePfizer Limited2014-04-10Not applicableEu
Pregabalin PfizerCapsule, hard25 mgOral usePfizer Limited2014-04-10Not applicableEu
Pregabalin PfizerCapsule, hard75 mgOral usePfizer Limited2014-04-10Not applicableEu
Pregabalin PfizerCapsule, hard200 mgOral usePfizer Limited2014-04-10Not applicableEu
Pregabalin PfizerCapsule, hard300 mgOral usePfizer Limited2014-04-10Not applicableEu
Pregabalin PfizerCapsule, hard50 mgOral usePfizer Limited2014-04-10Not applicableEu
Pregabalin PfizerCapsule, hard150 mgOral usePfizer Limited2014-04-10Not applicableEu
Pregabalin PfizerCapsule, hard75 mgOral usePfizer Limited2014-04-10Not applicableEu
Pregabalin PfizerCapsule, hard150 mgOral usePfizer Limited2014-04-10Not applicableEu
Pregabalin PfizerCapsule, hard25 mgOral usePfizer Limited2014-04-10Not applicableEu
Pregabalin PfizerCapsule, hard100 mgOral usePfizer Limited2014-04-10Not applicableEu
Pregabalin PfizerCapsule, hard225 mgOral usePfizer Limited2014-04-10Not applicableEu
Pregabalin PfizerCapsule, hard200 mgOral usePfizer Limited2014-04-10Not applicableEu
Pregabalin PfizerCapsule, hard25 mgOral usePfizer Limited2014-04-10Not applicableEu
Pregabalin PfizerCapsule, hard75 mgOral usePfizer Limited2014-04-10Not applicableEu
Pregabalin-150capsule150 mgoralSivem Pharmaceuticals Ulc2013-10-23Not applicableCanada
Pregabalin-225capsule225 mgoralSivem Pharmaceuticals UlcNot applicableNot applicableCanada
Pregabalin-25capsule25 mgoralSivem Pharmaceuticals Ulc2013-10-23Not applicableCanada
Pregabalin-300capsule300 mgoralSivem Pharmaceuticals UlcNot applicableNot applicableCanada
Pregabalin-50capsule50 mgoralSivem Pharmaceuticals Ulc2013-10-23Not applicableCanada
Pregabalin-75capsule75 mgoralSivem Pharmaceuticals Ulc2013-10-23Not applicableCanada
Ran-pregabalincapsule150 mgoralRanbaxy Pharmaceuticals Canada Inc.2013-02-15Not applicableCanada
Ran-pregabalincapsule25 mgoralRanbaxy Pharmaceuticals Canada Inc.2013-02-15Not applicableCanada
Ran-pregabalincapsule225 mgoralRanbaxy Pharmaceuticals Canada Inc.2013-02-15Not applicableCanada
Ran-pregabalincapsule50 mgoralRanbaxy Pharmaceuticals Canada Inc.2013-02-15Not applicableCanada
Ran-pregabalincapsule300 mgoralRanbaxy Pharmaceuticals Canada Inc.2013-02-15Not applicableCanada
Ran-pregabalincapsule75 mgoralRanbaxy Pharmaceuticals Canada Inc.2013-02-15Not applicableCanada
Ratio-pregabalincapsule75 mgoralTeva Canada LimitedNot applicableNot applicableCanada
Ratio-pregabalincapsule200 mgoralTeva Canada LimitedNot applicableNot applicableCanada
Ratio-pregabalincapsule150 mgoralTeva Canada LimitedNot applicableNot applicableCanada
Ratio-pregabalincapsule25 mgoralTeva Canada LimitedNot applicableNot applicableCanada
Ratio-pregabalincapsule225 mgoralTeva Canada LimitedNot applicableNot applicableCanada
Ratio-pregabalincapsule300 mgoralTeva Canada LimitedNot applicableNot applicableCanada
Ratio-pregabalincapsule50 mgoralTeva Canada LimitedNot applicableNot applicableCanada
Ratio-pregabalincapsule100 mgoralTeva Canada LimitedNot applicableNot applicableCanada
Riva-pregabalincapsule75 mgoralLaboratoire Riva Inc2013-02-15Not applicableCanada
Riva-pregabalincapsule150 mgoralLaboratoire Riva Inc2013-02-15Not applicableCanada
Riva-pregabalincapsule300 mgoralLaboratoire Riva Inc2013-02-15Not applicableCanada
Riva-pregabalincapsule25 mgoralLaboratoire Riva Inc2013-02-15Not applicableCanada
Riva-pregabalincapsule225 mgoralLaboratoire Riva IncNot applicableNot applicableCanada
Riva-pregabalincapsule50 mgoralLaboratoire Riva Inc2013-02-15Not applicableCanada
Sandoz Pregabalincapsule300 mgoralSandoz Canada Incorporated2013-02-15Not applicableCanada
Sandoz Pregabalincapsule50 mgoralSandoz Canada Incorporated2013-02-15Not applicableCanada
Sandoz Pregabalincapsule75 mgoralSandoz Canada Incorporated2013-02-15Not applicableCanada
Sandoz Pregabalincapsule150 mgoralSandoz Canada Incorporated2013-02-15Not applicableCanada
Sandoz Pregabalincapsule25 mgoralSandoz Canada Incorporated2013-02-15Not applicableCanada
Teva-pregabalincapsule25 mgoralTeva Canada Limited2013-02-15Not applicableCanada
Teva-pregabalincapsule225 mgoralTeva Canada Limited2013-02-15Not applicableCanada
Teva-pregabalincapsule50 mgoralTeva Canada Limited2013-02-15Not applicableCanada
Teva-pregabalincapsule100 mgoralTeva Canada LimitedNot applicableNot applicableCanada
Teva-pregabalincapsule300 mgoralTeva Canada Limited2013-02-15Not applicableCanada
Teva-pregabalincapsule75 mgoralTeva Canada Limited2013-02-15Not applicableCanada
Teva-pregabalincapsule200 mgoralTeva Canada LimitedNot applicableNot applicableCanada
Teva-pregabalincapsule150 mgoralTeva Canada Limited2013-02-15Not applicableCanada
Torrent-pregabalincapsule300 mgoralTorrent Pharmaceuticals LimitedNot applicableNot applicableCanada
Torrent-pregabalincapsule100 mgoralTorrent Pharmaceuticals LimitedNot applicableNot applicableCanada
Torrent-pregabalincapsule25 mgoralTorrent Pharmaceuticals LimitedNot applicableNot applicableCanada
Torrent-pregabalincapsule150 mgoralTorrent Pharmaceuticals LimitedNot applicableNot applicableCanada
Torrent-pregabalincapsule50 mgoralTorrent Pharmaceuticals LimitedNot applicableNot applicableCanada
Torrent-pregabalincapsule200 mgoralTorrent Pharmaceuticals LimitedNot applicableNot applicableCanada
Torrent-pregabalincapsule75 mgoralTorrent Pharmaceuticals LimitedNot applicableNot applicableCanada
Torrent-pregabalincapsule225 mgoralTorrent Pharmaceuticals LimitedNot applicableNot applicableCanada
Approved Generic Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Apo-pregabalincapsule150 mgoralApotex Inc2013-04-22Not applicableCanada
Apo-pregabalincapsule25 mgoralApotex Inc2013-06-06Not applicableCanada
Apo-pregabalincapsule225 mgoralApotex Inc2013-05-09Not applicableCanada
Apo-pregabalincapsule50 mgoralApotex Inc2013-06-06Not applicableCanada
Apo-pregabalincapsule300 mgoralApotex Inc2013-04-22Not applicableCanada
Apo-pregabalincapsule75 mgoralApotex Inc2013-04-22Not applicableCanada
Pregabalincapsule150 mg/1oralDIRECT RX2014-01-01Not applicableUs
Pregabalin AccordCapsule, hard150 mgOral useAccord Healthcare Limited2015-08-28Not applicableEu
Pregabalin AccordCapsule, hard25 mgOral useAccord Healthcare Limited2015-08-28Not applicableEu
Pregabalin AccordCapsule, hard200 mgOral useAccord Healthcare Limited2015-08-28Not applicableEu
Pregabalin AccordCapsule, hard225 mgOral useAccord Healthcare Limited2015-08-28Not applicableEu
Pregabalin AccordCapsule, hard50 mgOral useAccord Healthcare Limited2015-08-28Not applicableEu
Pregabalin AccordCapsule, hard75 mgOral useAccord Healthcare Limited2015-08-28Not applicableEu
Pregabalin AccordCapsule, hard100 mgOral useAccord Healthcare Limited2015-08-28Not applicableEu
Pregabalin AccordCapsule, hard150 mgOral useAccord Healthcare Limited2015-08-28Not applicableEu
Pregabalin AccordCapsule, hard225 mgOral useAccord Healthcare Limited2015-08-28Not applicableEu
Pregabalin AccordCapsule, hard25 mgOral useAccord Healthcare Limited2015-08-28Not applicableEu
Pregabalin AccordCapsule, hard300 mgOral useAccord Healthcare Limited2015-08-28Not applicableEu
Pregabalin AccordCapsule, hard75 mgOral useAccord Healthcare Limited2015-08-28Not applicableEu
Pregabalin AccordCapsule, hard150 mgOral useAccord Healthcare Limited2015-08-28Not applicableEu
Pregabalin AccordCapsule, hard25 mgOral useAccord Healthcare Limited2015-08-28Not applicableEu
Pregabalin AccordCapsule, hard200 mgOral useAccord Healthcare Limited2015-08-28Not applicableEu
Pregabalin AccordCapsule, hard300 mgOral useAccord Healthcare Limited2015-08-28Not applicableEu
Pregabalin AccordCapsule, hard50 mgOral useAccord Healthcare Limited2015-08-28Not applicableEu
Pregabalin AccordCapsule, hard100 mgOral useAccord Healthcare Limited2015-08-28Not applicableEu
Pregabalin AccordCapsule, hard100 mgOral useAccord Healthcare Limited2015-08-28Not applicableEu
Pregabalin AccordCapsule, hard200 mgOral useAccord Healthcare Limited2015-08-28Not applicableEu
Pregabalin AccordCapsule, hard225 mgOral useAccord Healthcare Limited2015-08-28Not applicableEu
Pregabalin AccordCapsule, hard50 mgOral useAccord Healthcare Limited2015-08-28Not applicableEu
Pregabalin AccordCapsule, hard300 mgOral useAccord Healthcare Limited2015-08-28Not applicableEu
Pregabalin AccordCapsule, hard75 mgOral useAccord Healthcare Limited2015-08-28Not applicableEu
Pregabalin AccordCapsule, hard150 mgOral useAccord Healthcare Limited2015-08-28Not applicableEu
Pregabalin AccordCapsule, hard25 mgOral useAccord Healthcare Limited2015-08-28Not applicableEu
Pregabalin AccordCapsule, hard200 mgOral useAccord Healthcare Limited2015-08-28Not applicableEu
Pregabalin AccordCapsule, hard225 mgOral useAccord Healthcare Limited2015-08-28Not applicableEu
Pregabalin AccordCapsule, hard50 mgOral useAccord Healthcare Limited2015-08-28Not applicableEu
Pregabalin AccordCapsule, hard75 mgOral useAccord Healthcare Limited2015-08-28Not applicableEu
Pregabalin AccordCapsule, hard100 mgOral useAccord Healthcare Limited2015-08-28Not applicableEu
Pregabalin AccordCapsule, hard150 mgOral useAccord Healthcare Limited2015-08-28Not applicableEu
Pregabalin AccordCapsule, hard225 mgOral useAccord Healthcare Limited2015-08-28Not applicableEu
Pregabalin AccordCapsule, hard25 mgOral useAccord Healthcare Limited2015-08-28Not applicableEu
Pregabalin AccordCapsule, hard300 mgOral useAccord Healthcare Limited2015-08-28Not applicableEu
Pregabalin AccordCapsule, hard75 mgOral useAccord Healthcare Limited2015-08-28Not applicableEu
Pregabalin AccordCapsule, hard150 mgOral useAccord Healthcare Limited2015-08-28Not applicableEu
Pregabalin AccordCapsule, hard25 mgOral useAccord Healthcare Limited2015-08-28Not applicableEu
Pregabalin AccordCapsule, hard200 mgOral useAccord Healthcare Limited2015-08-28Not applicableEu
Pregabalin AccordCapsule, hard300 mgOral useAccord Healthcare Limited2015-08-28Not applicableEu
Pregabalin AccordCapsule, hard50 mgOral useAccord Healthcare Limited2015-08-28Not applicableEu
Pregabalin AccordCapsule, hard100 mgOral useAccord Healthcare Limited2015-08-28Not applicableEu
Pregabalin AccordCapsule, hard100 mgOral useAccord Healthcare Limited2015-08-28Not applicableEu
Pregabalin AccordCapsule, hard200 mgOral useAccord Healthcare Limited2015-08-28Not applicableEu
Pregabalin AccordCapsule, hard225 mgOral useAccord Healthcare Limited2015-08-28Not applicableEu
Pregabalin AccordCapsule, hard50 mgOral useAccord Healthcare Limited2015-08-28Not applicableEu
Pregabalin AccordCapsule, hard75 mgOral useAccord Healthcare Limited2015-08-28Not applicableEu
Pregabalin AccordCapsule, hard75 mgOral useAccord Healthcare Limited2015-08-28Not applicableEu
Pregabalin AccordCapsule, hard150 mgOral useAccord Healthcare Limited2015-08-28Not applicableEu
Pregabalin AccordCapsule, hard25 mgOral useAccord Healthcare Limited2015-08-28Not applicableEu
Pregabalin AccordCapsule, hard200 mgOral useAccord Healthcare Limited2015-08-28Not applicableEu
Pregabalin AccordCapsule, hard300 mgOral useAccord Healthcare Limited2015-08-28Not applicableEu
Pregabalin AccordCapsule, hard50 mgOral useAccord Healthcare Limited2015-08-28Not applicableEu
Pregabalin AccordCapsule, hard75 mgOral useAccord Healthcare Limited2015-08-28Not applicableEu
Pregabalin AccordCapsule, hard100 mgOral useAccord Healthcare Limited2015-08-28Not applicableEu
Pregabalin AccordCapsule, hard200 mgOral useAccord Healthcare Limited2015-08-28Not applicableEu
Pregabalin AccordCapsule, hard225 mgOral useAccord Healthcare Limited2015-08-28Not applicableEu
Pregabalin AccordCapsule, hard25 mgOral useAccord Healthcare Limited2015-08-28Not applicableEu
Pregabalin AccordCapsule, hard300 mgOral useAccord Healthcare Limited2015-08-28Not applicableEu
Pregabalin AccordCapsule, hard75 mgOral useAccord Healthcare Limited2015-08-28Not applicableEu
Pregabalin AccordCapsule, hard150 mgOral useAccord Healthcare Limited2015-08-28Not applicableEu
Pregabalin AccordCapsule, hard25 mgOral useAccord Healthcare Limited2015-08-28Not applicableEu
Pregabalin AccordCapsule, hard225 mgOral useAccord Healthcare Limited2015-08-28Not applicableEu
Pregabalin AccordCapsule, hard300 mgOral useAccord Healthcare Limited2015-08-28Not applicableEu
Pregabalin AccordCapsule, hard50 mgOral useAccord Healthcare Limited2015-08-28Not applicableEu
Pregabalin AccordCapsule, hard100 mgOral useAccord Healthcare Limited2015-08-28Not applicableEu
Pregabalin AccordCapsule, hard50 mgOral useAccord Healthcare Limited2015-08-28Not applicableEu
Pregabalin AccordCapsule, hard75 mgOral useAccord Healthcare Limited2015-08-28Not applicableEu
Pregabalin AccordCapsule, hard150 mgOral useAccord Healthcare Limited2015-08-28Not applicableEu
Pregabalin AccordCapsule, hard200 mgOral useAccord Healthcare Limited2015-08-28Not applicableEu
Pregabalin AccordCapsule, hard225 mgOral useAccord Healthcare Limited2015-08-28Not applicableEu
Pregabalin AccordCapsule, hard150 mgOral useAccord Healthcare Limited2015-08-28Not applicableEu
Pregabalin AccordCapsule, hard25 mgOral useAccord Healthcare Limited2015-08-28Not applicableEu
Pregabalin AccordCapsule, hard200 mgOral useAccord Healthcare Limited2015-08-28Not applicableEu
Pregabalin AccordCapsule, hard300 mgOral useAccord Healthcare Limited2015-08-28Not applicableEu
Pregabalin AccordCapsule, hard50 mgOral useAccord Healthcare Limited2015-08-28Not applicableEu
Pregabalin AccordCapsule, hard100 mgOral useAccord Healthcare Limited2015-08-28Not applicableEu
Pregabalin AccordCapsule, hard100 mgOral useAccord Healthcare Limited2015-08-28Not applicableEu
Pregabalin AccordCapsule, hard200 mgOral useAccord Healthcare Limited2015-08-28Not applicableEu
Pregabalin AccordCapsule, hard225 mgOral useAccord Healthcare Limited2015-08-28Not applicableEu
Pregabalin AccordCapsule, hard50 mgOral useAccord Healthcare Limited2015-08-28Not applicableEu
Pregabalin AccordCapsule, hard300 mgOral useAccord Healthcare Limited2015-08-28Not applicableEu
Pregabalin AccordCapsule, hard75 mgOral useAccord Healthcare Limited2015-08-28Not applicableEu
Pregabalin AccordCapsule, hard300 mgOral useAccord Healthcare Limited2015-08-28Not applicableEu
Pregabalin AccordCapsule, hard75 mgOral useAccord Healthcare Limited2015-08-28Not applicableEu
Pregabalin AccordCapsule, hard100 mgOral useAccord Healthcare Limited2015-08-28Not applicableEu
Pregabalin AccordCapsule, hard150 mgOral useAccord Healthcare Limited2015-08-28Not applicableEu
Pregabalin AccordCapsule, hard25 mgOral useAccord Healthcare Limited2015-08-28Not applicableEu
Pregabalin AccordCapsule, hard225 mgOral useAccord Healthcare Limited2015-08-28Not applicableEu
Pregabalin MylanCapsule, hard25 mgOral useGenerics (Uk) Limited2015-06-25Not applicableEu
Pregabalin MylanCapsule, hard75 mgOral useGenerics (Uk) Limited2015-06-25Not applicableEu
Pregabalin MylanCapsule, hard150 mgOral useGenerics (Uk) Limited2015-06-25Not applicableEu
Pregabalin MylanCapsule, hard300 mgOral useGenerics (Uk) Limited2015-06-25Not applicableEu
Pregabalin MylanCapsule, hard50 mgOral useGenerics (Uk) Limited2015-06-25Not applicableEu
Pregabalin MylanCapsule, hard100 mgOral useGenerics (Uk) Limited2015-06-25Not applicableEu
Pregabalin MylanCapsule, hard225 mgOral useGenerics (Uk) Limited2015-06-25Not applicableEu
Pregabalin MylanCapsule, hard25 mgOral useGenerics (Uk) Limited2015-06-25Not applicableEu
Pregabalin MylanCapsule, hard75 mgOral useGenerics (Uk) Limited2015-06-25Not applicableEu
Pregabalin MylanCapsule, hard200 mgOral useGenerics (Uk) Limited2015-06-25Not applicableEu
Pregabalin MylanCapsule, hard50 mgOral useGenerics (Uk) Limited2015-06-25Not applicableEu
Pregabalin MylanCapsule, hard150 mgOral useGenerics (Uk) Limited2015-06-25Not applicableEu
Pregabalin MylanCapsule, hard225 mgOral useGenerics (Uk) Limited2015-06-25Not applicableEu
Pregabalin MylanCapsule, hard25 mgOral useGenerics (Uk) Limited2015-06-25Not applicableEu
Pregabalin MylanCapsule, hard75 mgOral useGenerics (Uk) Limited2015-06-25Not applicableEu
Pregabalin MylanCapsule, hard150 mgOral useGenerics (Uk) Limited2015-06-25Not applicableEu
Pregabalin MylanCapsule, hard300 mgOral useGenerics (Uk) Limited2015-06-25Not applicableEu
Pregabalin MylanCapsule, hard50 mgOral useGenerics (Uk) Limited2015-06-25Not applicableEu
Pregabalin MylanCapsule, hard100 mgOral useGenerics (Uk) Limited2015-06-25Not applicableEu
Pregabalin MylanCapsule, hard225 mgOral useGenerics (Uk) Limited2015-06-25Not applicableEu
Pregabalin MylanCapsule, hard25 mgOral useGenerics (Uk) Limited2015-06-25Not applicableEu
Pregabalin MylanCapsule, hard75 mgOral useGenerics (Uk) Limited2015-06-25Not applicableEu
Pregabalin MylanCapsule, hard200 mgOral useGenerics (Uk) Limited2015-06-25Not applicableEu
Pregabalin MylanCapsule, hard150 mgOral useGenerics (Uk) Limited2015-06-25Not applicableEu
Pregabalin MylanCapsule, hard300 mgOral useGenerics (Uk) Limited2015-06-25Not applicableEu
Pregabalin MylanCapsule, hard50 mgOral useGenerics (Uk) Limited2015-06-25Not applicableEu
Pregabalin MylanCapsule, hard25 mgOral useGenerics (Uk) Limited2015-06-25Not applicableEu
Pregabalin MylanCapsule, hard75 mgOral useGenerics (Uk) Limited2015-06-25Not applicableEu
Pregabalin MylanCapsule, hard150 mgOral useGenerics (Uk) Limited2015-06-25Not applicableEu
Pregabalin MylanCapsule, hard300 mgOral useGenerics (Uk) Limited2015-06-25Not applicableEu
Pregabalin MylanCapsule, hard50 mgOral useGenerics (Uk) Limited2015-06-25Not applicableEu
Pregabalin MylanCapsule, hard100 mgOral useGenerics (Uk) Limited2015-06-25Not applicableEu
Pregabalin MylanCapsule, hard225 mgOral useGenerics (Uk) Limited2015-06-25Not applicableEu
Pregabalin MylanCapsule, hard100 mgOral useGenerics (Uk) Limited2015-06-25Not applicableEu
Pregabalin MylanCapsule, hard200 mgOral useGenerics (Uk) Limited2015-06-25Not applicableEu
Pregabalin MylanCapsule, hard25 mgOral useGenerics (Uk) Limited2015-06-25Not applicableEu
Pregabalin MylanCapsule, hard25 mgOral useGenerics (Uk) Limited2015-06-25Not applicableEu
Pregabalin MylanCapsule, hard75 mgOral useGenerics (Uk) Limited2015-06-25Not applicableEu
Pregabalin MylanCapsule, hard150 mgOral useGenerics (Uk) Limited2015-06-25Not applicableEu
Pregabalin MylanCapsule, hard300 mgOral useGenerics (Uk) Limited2015-06-25Not applicableEu
Pregabalin MylanCapsule, hard25 mgOral useGenerics (Uk) Limited2015-06-25Not applicableEu
Pregabalin MylanCapsule, hard75 mgOral useGenerics (Uk) Limited2015-06-25Not applicableEu
Pregabalin MylanCapsule, hard200 mgOral useGenerics (Uk) Limited2015-06-25Not applicableEu
Pregabalin MylanCapsule, hard300 mgOral useGenerics (Uk) Limited2015-06-25Not applicableEu
Pregabalin MylanCapsule, hard50 mgOral useGenerics (Uk) Limited2015-06-25Not applicableEu
Pregabalin MylanCapsule, hard150 mgOral useGenerics (Uk) Limited2015-06-25Not applicableEu
Pregabalin MylanCapsule, hard225 mgOral useGenerics (Uk) Limited2015-06-25Not applicableEu
Pregabalin MylanCapsule, hard50 mgOral useGenerics (Uk) Limited2015-06-25Not applicableEu
Pregabalin MylanCapsule, hard100 mgOral useGenerics (Uk) Limited2015-06-25Not applicableEu
Pregabalin MylanCapsule, hard200 mgOral useGenerics (Uk) Limited2015-06-25Not applicableEu
Pregabalin Mylan PharmaCapsule, hard50 mgOral useGenerics Uk Limited2015-06-25Not applicableEu
Pregabalin Mylan PharmaCapsule, hard100 mgOral useGenerics Uk Limited2015-06-25Not applicableEu
Pregabalin Mylan PharmaCapsule, hard225 mgOral useGenerics Uk Limited2015-06-25Not applicableEu
Pregabalin Mylan PharmaCapsule, hard25 mgOral useGenerics Uk Limited2015-06-25Not applicableEu
Pregabalin Mylan PharmaCapsule, hard75 mgOral useGenerics Uk Limited2015-06-25Not applicableEu
Pregabalin Mylan PharmaCapsule, hard200 mgOral useGenerics Uk Limited2015-06-25Not applicableEu
Pregabalin Mylan PharmaCapsule, hard300 mgOral useGenerics Uk Limited2015-06-25Not applicableEu
Pregabalin Mylan PharmaCapsule, hard150 mgOral useGenerics Uk Limited2015-06-25Not applicableEu
Pregabalin Mylan PharmaCapsule, hard300 mgOral useGenerics Uk Limited2015-06-25Not applicableEu
Pregabalin Mylan PharmaCapsule, hard25 mgOral useGenerics Uk Limited2015-06-25Not applicableEu
Pregabalin Mylan PharmaCapsule, hard75 mgOral useGenerics Uk Limited2015-06-25Not applicableEu
Pregabalin Mylan PharmaCapsule, hard50 mgOral useGenerics Uk Limited2015-06-25Not applicableEu
Pregabalin Mylan PharmaCapsule, hard100 mgOral useGenerics Uk Limited2015-06-25Not applicableEu
Pregabalin Mylan PharmaCapsule, hard200 mgOral useGenerics Uk Limited2015-06-25Not applicableEu
Pregabalin Mylan PharmaCapsule, hard50 mgOral useGenerics Uk Limited2015-06-25Not applicableEu
Pregabalin Mylan PharmaCapsule, hard150 mgOral useGenerics Uk Limited2015-06-25Not applicableEu
Pregabalin Mylan PharmaCapsule, hard225 mgOral useGenerics Uk Limited2015-06-25Not applicableEu
Pregabalin Mylan PharmaCapsule, hard25 mgOral useGenerics Uk Limited2015-06-25Not applicableEu
Pregabalin Mylan PharmaCapsule, hard75 mgOral useGenerics Uk Limited2015-06-25Not applicableEu
Pregabalin Mylan PharmaCapsule, hard200 mgOral useGenerics Uk Limited2015-06-25Not applicableEu
Pregabalin Mylan PharmaCapsule, hard25 mgOral useGenerics Uk Limited2015-06-25Not applicableEu
Pregabalin Mylan PharmaCapsule, hard75 mgOral useGenerics Uk Limited2015-06-25Not applicableEu
Pregabalin Mylan PharmaCapsule, hard150 mgOral useGenerics Uk Limited2015-06-25Not applicableEu
Pregabalin Mylan PharmaCapsule, hard300 mgOral useGenerics Uk Limited2015-06-25Not applicableEu
Pregabalin Mylan PharmaCapsule, hard50 mgOral useGenerics Uk Limited2015-06-25Not applicableEu
Pregabalin Mylan PharmaCapsule, hard100 mgOral useGenerics Uk Limited2015-06-25Not applicableEu
Pregabalin Mylan PharmaCapsule, hard225 mgOral useGenerics Uk Limited2015-06-25Not applicableEu
Pregabalin Mylan PharmaCapsule, hard50 mgOral useGenerics Uk Limited2015-06-25Not applicableEu
Pregabalin Mylan PharmaCapsule, hard150 mgOral useGenerics Uk Limited2015-06-25Not applicableEu
Pregabalin Mylan PharmaCapsule, hard225 mgOral useGenerics Uk Limited2015-06-25Not applicableEu
Pregabalin Mylan PharmaCapsule, hard25 mgOral useGenerics Uk Limited2015-06-25Not applicableEu
Pregabalin Mylan PharmaCapsule, hard75 mgOral useGenerics Uk Limited2015-06-25Not applicableEu
Pregabalin Mylan PharmaCapsule, hard200 mgOral useGenerics Uk Limited2015-06-25Not applicableEu
Pregabalin Mylan PharmaCapsule, hard25 mgOral useGenerics Uk Limited2015-06-25Not applicableEu
Pregabalin Mylan PharmaCapsule, hard75 mgOral useGenerics Uk Limited2015-06-25Not applicableEu
Pregabalin Mylan PharmaCapsule, hard150 mgOral useGenerics Uk Limited2015-06-25Not applicableEu
Pregabalin Mylan PharmaCapsule, hard300 mgOral useGenerics Uk Limited2015-06-25Not applicableEu
Pregabalin Mylan PharmaCapsule, hard50 mgOral useGenerics Uk Limited2015-06-25Not applicableEu
Pregabalin Mylan PharmaCapsule, hard100 mgOral useGenerics Uk Limited2015-06-25Not applicableEu
Pregabalin Mylan PharmaCapsule, hard225 mgOral useGenerics Uk Limited2015-06-25Not applicableEu
Pregabalin Mylan PharmaCapsule, hard300 mgOral useGenerics Uk Limited2015-06-25Not applicableEu
Pregabalin Mylan PharmaCapsule, hard50 mgOral useGenerics Uk Limited2015-06-25Not applicableEu
Pregabalin Mylan PharmaCapsule, hard150 mgOral useGenerics Uk Limited2015-06-25Not applicableEu
Pregabalin Mylan PharmaCapsule, hard200 mgOral useGenerics Uk Limited2015-06-25Not applicableEu
Pregabalin Mylan PharmaCapsule, hard25 mgOral useGenerics Uk Limited2015-06-25Not applicableEu
Pregabalin Mylan PharmaCapsule, hard100 mgOral useGenerics Uk Limited2015-06-25Not applicableEu
Pregabalin Mylan PharmaCapsule, hard25 mgOral useGenerics Uk Limited2015-06-25Not applicableEu
Pregabalin Mylan PharmaCapsule, hard75 mgOral useGenerics Uk Limited2015-06-25Not applicableEu
Pregabalin Mylan PharmaCapsule, hard150 mgOral useGenerics Uk Limited2015-06-25Not applicableEu
Pregabalin Mylan PharmaCapsule, hard300 mgOral useGenerics Uk Limited2015-06-25Not applicableEu
Pregabalin ZentivaCapsule, hard50 mgOral useZentiva, K.S.2015-07-17Not applicableEu
Pregabalin ZentivaCapsule, hard200 mgOral useZentiva, K.S.2015-07-17Not applicableEu
Pregabalin ZentivaCapsule, hard100 mgOral useZentiva, K.S.2015-07-17Not applicableEu
Pregabalin ZentivaCapsule, hard75 mgOral useZentiva, K.S.2015-07-17Not applicableEu
Pregabalin ZentivaCapsule, hard300 mgOral useZentiva, K.S.2015-07-17Not applicableEu
Pregabalin ZentivaCapsule, hard25 mgOral useZentiva, K.S.2015-07-17Not applicableEu
Pregabalin ZentivaCapsule, hard150 mgOral useZentiva, K.S.2015-07-17Not applicableEu
Pregabalin ZentivaCapsule, hard50 mgOral useZentiva, K.S.2015-07-17Not applicableEu
Pregabalin ZentivaCapsule, hard225 mgOral useZentiva, K.S.2015-07-17Not applicableEu
Pregabalin ZentivaCapsule, hard25 mgOral useZentiva, K.S.2015-07-17Not applicableEu
Pregabalin ZentivaCapsule, hard100 mgOral useZentiva, K.S.2015-07-17Not applicableEu
Pregabalin ZentivaCapsule, hard75 mgOral useZentiva, K.S.2015-07-17Not applicableEu
Pregabalin ZentivaCapsule, hard300 mgOral useZentiva, K.S.2015-07-17Not applicableEu
Pregabalin ZentivaCapsule, hard25 mgOral useZentiva, K.S.2015-07-17Not applicableEu
Pregabalin ZentivaCapsule, hard200 mgOral useZentiva, K.S.2015-07-17Not applicableEu
Pregabalin ZentivaCapsule, hard225 mgOral useZentiva, K.S.2015-07-17Not applicableEu
Pregabalin ZentivaCapsule, hard50 mgOral useZentiva, K.S.2015-07-17Not applicableEu
Pregabalin ZentivaCapsule, hard25 mgOral useZentiva, K.S.2015-07-17Not applicableEu
Pregabalin ZentivaCapsule, hard150 mgOral useZentiva, K.S.2015-07-17Not applicableEu
Pregabalin ZentivaCapsule, hard75 mgOral useZentiva, K.S.2015-07-17Not applicableEu
Pregabalin ZentivaCapsule, hard300 mgOral useZentiva, K.S.2015-07-17Not applicableEu
Pregabalin ZentivaCapsule, hard50 mgOral useZentiva, K.S.2015-07-17Not applicableEu
Pregabalin ZentivaCapsule, hard200 mgOral useZentiva, K.S.2015-07-17Not applicableEu
Pregabalin ZentivaCapsule, hard50 mgOral useZentiva, K.S.2015-07-17Not applicableEu
Pregabalin ZentivaCapsule, hard225 mgOral useZentiva, K.S.2015-07-17Not applicableEu
Pregabalin ZentivaCapsule, hard25 mgOral useZentiva, K.S.2015-07-17Not applicableEu
Pregabalin ZentivaCapsule, hard150 mgOral useZentiva, K.S.2015-07-17Not applicableEu
Pregabalin ZentivaCapsule, hard100 mgOral useZentiva, K.S.2015-07-17Not applicableEu
Approved Over the Counter ProductsNot Available
Unapproved/Other Products Not Available
International BrandsNot Available
Brand mixturesNot Available
SaltsNot Available
Categories
UNII55JG375S6M
CAS number148553-50-8
WeightAverage: 159.2261
Monoisotopic: 159.125928793
Chemical FormulaC8H17NO2
InChI KeyInChIKey=AYXYPKUFHZROOJ-ZETCQYMHSA-N
InChI
InChI=1S/C8H17NO2/c1-6(2)3-7(5-9)4-8(10)11/h6-7H,3-5,9H2,1-2H3,(H,10,11)/t7-/m0/s1
IUPAC Name
(3S)-3-(aminomethyl)-5-methylhexanoic acid
SMILES
CC(C)C[[email protected]](CN)CC(O)=O
Taxonomy
DescriptionThis compound belongs to the class of organic compounds known as gamma amino acids and derivatives. These are amino acids having a (-NH2) group attached to the gamma carbon atom.
KingdomOrganic compounds
Super ClassOrganic acids and derivatives
ClassCarboxylic acids and derivatives
Sub ClassAmino acids, peptides, and analogues
Direct ParentGamma amino acids and derivatives
Alternative Parents
Substituents
  • Gamma amino acid or derivatives
  • Medium-chain fatty acid
  • Branched fatty acid
  • Amino fatty acid
  • Fatty acyl
  • Fatty acid
  • Monocarboxylic acid or derivatives
  • Carboxylic acid
  • Hydrocarbon derivative
  • Primary amine
  • Organooxygen compound
  • Organonitrogen compound
  • Primary aliphatic amine
  • Carbonyl group
  • Amine
  • Aliphatic acyclic compound
Molecular FrameworkAliphatic acyclic compounds
External Descriptors
Pharmacology
IndicationPregabalin is used for the management of neuropathic pain associated with diabetic peripheral neuropathy or spinal cord injury, and postherpetic neuralgia. It is also used as adjunctive therapy for adult patients with partial onset seizures and management of fibromyalgia.
PharmacodynamicsPregabalin is a new anticonvulsant drug indicated as an add on therapy for partial onset seizures and for certain types of neuropathic pain. It was designed as a more potent successor to a related drug, gabapentin. Pregabalin binds to the alpha2-delta subunit of the voltage-gated calcium channel in the central nervous system. While pregabalin is a structural derivative of the inhibitory neurotransmitter gamma- aminobutyric acid (GABA), it does not bind directly to GABAA, GABAB, or benzodiazepine receptors, does not augment GABAA responses in cultured neurons, does not alter rat brain GABA concentration or have acute effects on GABA uptake or degradation. However, in cultured neurons prolonged application of pregabalin increases the density of GABA transporter protein and increases the rate of functional GABA transport. Pregabalin does not block sodium channels, is not active at opiate receptors, and does not alter cyclooxygenase enzyme activity. It is inactive at serotonin and dopamine receptors and does not inhibit dopamine, serotonin, or noradrenaline reuptake.
Mechanism of actionPregabalin binds with high affinity to the alpha2-delta site (an auxiliary subunit of voltage-gated calcium channels) in central nervous system tissues. Although the mechanism of action of pregabalin is unknown, results with genetically modified mice and with compounds structurally related to pregabalin (such as gabapentin) suggest that binding to the alpha2-delta subunit may be involved in pregabalin's antinociceptive and antiseizure effects in animal models. In vitro, pregabalin reduces the calcium-dependent release of several neurotransmitters, possibly by modulation of calcium channel function. Studies also suggest that the descending noradrenergic and serotonergic pathways originating from the brainstem may be involved with the mechanism of pregabalin. Interestingly, although pregabalin is a structural derivative of inhibitory neurotransmitter gamma-aminobutyric acid (GABA), it does not bind directly to GABA or benzodiazepine receptors. The sodium channels, opiate receptors, and cyclooxygenase enzymes are not involved with the mechanism of pregabalin. It is also inactive at serotonin and dopamine receptors and does not inhibit dopamine, serotonin, or noradrenaline reuptake.
Related Articles
AbsorptionPregabalin is well absorbed after oral administration. When an oral administration of pregabalin under fasting conditions is given, the pharmacokinetic parameters are as follows: Tmax = 1.5 hours; Oral bioavailability = >90% (independent of dose); Time to steady state = 24-48 hours. It is also a substrate for the L-type transport system.
Volume of distribution

Apparent volume of distribution, oral administration = 0.5 L/kg.
Pregabalin has been shown to cross the placenta in rats and is present in the milk of lactating rats.

Protein bindingPregabalin does not bind to plasma proteins.
Metabolism

Pregabalin undergoes negligible metabolism in humans.

Route of elimination90% of the dose was recovered in the urine as the parent compound. The N-methylated derivative of pregabalin, the major metabolite was found in the urine and accounted for 0.9% of the dose. Pregabalin (S-enantiomer) did not undergo racemization to the R-enantiomer.
Half life6.3 hours
Clearance

Renal clearance, healthy subjects = 67.0 – 80.9 mL/min. Because pregabalin is not bound to plasma protein, this rate suggests the involvement of renal tubular reabsorption.

ToxicityMost common adverse reactions (≥5% and twice placebo) are dizziness, somnolence, dry mouth, edema, blurred vision, weight gain and thinking abnormal (primarily difficulty with concentration/attention).
Affected organisms
  • Humans and other mammals
PathwaysNot Available
SNP Mediated EffectsNot Available
SNP Mediated Adverse Drug ReactionsNot Available
ADMET
Predicted ADMET features
PropertyValueProbability
Human Intestinal Absorption+0.9727
Blood Brain Barrier+0.9382
Caco-2 permeable-0.6531
P-glycoprotein substrateNon-substrate0.683
P-glycoprotein inhibitor INon-inhibitor0.965
P-glycoprotein inhibitor IINon-inhibitor0.9424
Renal organic cation transporterNon-inhibitor0.9245
CYP450 2C9 substrateNon-substrate0.8758
CYP450 2D6 substrateNon-substrate0.7926
CYP450 3A4 substrateNon-substrate0.6914
CYP450 1A2 substrateNon-inhibitor0.9385
CYP450 2C9 inhibitorNon-inhibitor0.9425
CYP450 2D6 inhibitorNon-inhibitor0.9539
CYP450 2C19 inhibitorNon-inhibitor0.9629
CYP450 3A4 inhibitorNon-inhibitor0.9352
CYP450 inhibitory promiscuityLow CYP Inhibitory Promiscuity0.9784
Ames testNon AMES toxic0.938
CarcinogenicityNon-carcinogens0.5678
BiodegradationReady biodegradable0.8201
Rat acute toxicity1.7046 LD50, mol/kg Not applicable
hERG inhibition (predictor I)Weak inhibitor0.9868
hERG inhibition (predictor II)Non-inhibitor0.8909
ADMET data is predicted using admetSAR, a free tool for evaluating chemical ADMET properties. (23092397 )
Pharmacoeconomics
Manufacturers
Packagers
Dosage forms
FormRouteStrength
Capsuleoral100 mg/1
Capsuleoral100 mg
Capsuleoral150 mg
Capsuleoral150 mg/1
Capsuleoral200 mg
Capsuleoral200 mg/1
Capsuleoral225 mg/1
Capsuleoral225 mg
Capsuleoral25 mg/1
Capsuleoral25 mg
Capsuleoral300 mg
Capsuleoral300 mg/1
Capsuleoral50 mg
Capsuleoral50 mg/1
Capsuleoral75 mg/1
Capsuleoral75 mg
Solutionoral20 mg/mL
Capsule, hardOral use100 mg
Capsule, hardOral use150 mg
Capsule, hardOral use200 mg
Capsule, hardOral use225 mg
Capsule, hardOral use25 mg
Capsule, hardOral use300 mg
Capsule, hardOral use50 mg
Capsule, hardOral use75 mg
Prices
Unit descriptionCostUnit
Lyrica 100 mg capsule2.88USD capsule
Lyrica 150 mg capsule2.88USD capsule
Lyrica 50 mg capsule2.88USD capsule
Lyrica 75 mg capsule2.88USD capsule
Lyrica 200 mg capsule2.75USD capsule
Lyrica 225 mg capsule2.75USD capsule
Lyrica 25 mg capsule2.75USD capsule
Lyrica 300 mg capsule2.75USD capsule
DrugBank does not sell nor buy drugs. Pricing information is supplied for informational purposes only.
Patents
Patent NumberPediatric ExtensionApprovedExpires (estimated)
CA2297163 No2001-11-202018-08-18Canada
CA2327285 No2005-06-142019-05-10Canada
US5563175 No1993-10-082013-10-08Us
US6001876 No1998-12-302018-12-30Us
US6197819 No1998-12-302018-12-30Us
USRE41920 No1998-12-302018-12-30Us
Properties
StateSolid
Experimental Properties
PropertyValueSource
water solubilityFreely soluble FDA label
logP-1.35FDA label
pKa4.2 and 10.6 FDA label
Predicted Properties
PropertyValueSource
Water Solubility11.3 mg/mLALOGPS
logP-1.4ALOGPS
logP-1.3ChemAxon
logS-1.1ALOGPS
pKa (Strongest Acidic)4.8ChemAxon
pKa (Strongest Basic)10.23ChemAxon
Physiological Charge0ChemAxon
Hydrogen Acceptor Count3ChemAxon
Hydrogen Donor Count2ChemAxon
Polar Surface Area63.32 Å2ChemAxon
Rotatable Bond Count5ChemAxon
Refractivity43.68 m3·mol-1ChemAxon
Polarizability18.08 Å3ChemAxon
Number of Rings0ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleYesChemAxon
Spectra
Mass Spec (NIST)Not Available
Spectra
Spectrum TypeDescriptionSplash Key
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, PositiveNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, PositiveNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, PositiveNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, NegativeNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, NegativeNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, NegativeNot Available
References
Synthesis Reference

Mark Burk, “Asymmetric synthesis of pregabalin.” U.S. Patent US20030212290, issued November 13, 2003.

US20030212290
General References
  1. Authors unspecified: Schedules of controlled substances: placement of pregabalin into schedule V. Final rule. Fed Regist. 2005 Jul 28;70(144):43633-5. [PubMed:16050051 ]
  2. Su TZ, Feng MR, Weber ML: Mediation of highly concentrative uptake of pregabalin by L-type amino acid transport in Chinese hamster ovary and Caco-2 cells. J Pharmacol Exp Ther. 2005 Jun;313(3):1406-15. Epub 2005 Mar 15. [PubMed:15769862 ]
  3. Li Z, Taylor CP, Weber M, Piechan J, Prior F, Bian F, Cui M, Hoffman D, Donevan S: Pregabalin is a potent and selective ligand for alpha(2)delta-1 and alpha(2)delta-2 calcium channel subunits. Eur J Pharmacol. 2011 Sep 30;667(1-3):80-90. doi: 10.1016/j.ejphar.2011.05.054. Epub 2011 Jun 1. [PubMed:21651903 ]
External Links
ATC CodesN03AX16
AHFS Codes
  • 28:12.92
PDB EntriesNot Available
FDA labelDownload (3.46 MB)
MSDSDownload (106 KB)
Interactions
Drug Interactions
Drug
2-HYDROXY-1,4-NAPHTHOQUINONEThe risk or severity of adverse effects can be increased when 2-HYDROXY-1,4-NAPHTHOQUINONE is combined with Pregabalin.
2-mercaptobenzothiazoleThe risk or severity of adverse effects can be increased when 2-mercaptobenzothiazole is combined with Pregabalin.
7-NitroindazoleThe risk or severity of adverse effects can be increased when Pregabalin is combined with 7-Nitroindazole.
AcepromazineThe risk or severity of adverse effects can be increased when Pregabalin is combined with Acepromazine.
AceprometazineThe risk or severity of adverse effects can be increased when Pregabalin is combined with Aceprometazine.
adipiplonThe risk or severity of adverse effects can be increased when Pregabalin is combined with adipiplon.
AgomelatineThe risk or severity of adverse effects can be increased when Pregabalin is combined with Agomelatine.
AlfaxaloneThe risk or severity of adverse effects can be increased when Pregabalin is combined with Alfaxalone.
AlfentanilThe risk or severity of adverse effects can be increased when Pregabalin is combined with Alfentanil.
AlfuzosinAlfuzosin may increase the hypotensive activities of Pregabalin.
AlphacetylmethadolThe risk or severity of adverse effects can be increased when Pregabalin is combined with Alphacetylmethadol.
AlprazolamThe risk or severity of adverse effects can be increased when Pregabalin is combined with Alprazolam.
AmisulprideThe risk or severity of adverse effects can be increased when Pregabalin is combined with Amisulpride.
AmitriptylineThe risk or severity of adverse effects can be increased when Pregabalin is combined with Amitriptyline.
AmobarbitalThe metabolism of Pregabalin can be increased when combined with Amobarbital.
AmobarbitalThe risk or severity of adverse effects can be increased when Pregabalin is combined with Amobarbital.
AmorolfineThe risk or severity of adverse effects can be increased when Amorolfine is combined with Pregabalin.
AmoxapineThe risk or severity of adverse effects can be increased when Pregabalin is combined with Amoxapine.
AmperozideThe risk or severity of adverse effects can be increased when Pregabalin is combined with Amperozide.
Amphotericin BThe risk or severity of adverse effects can be increased when Amphotericin B is combined with Pregabalin.
AN2690The risk or severity of adverse effects can be increased when AN2690 is combined with Pregabalin.
AnidulafunginThe risk or severity of adverse effects can be increased when Anidulafungin is combined with Pregabalin.
AripiprazoleThe risk or severity of adverse effects can be increased when Pregabalin is combined with Aripiprazole.
ArtemetherThe risk or severity of adverse effects can be increased when Artemether is combined with Pregabalin.
ArticaineThe risk or severity of adverse effects can be increased when Pregabalin is combined with Articaine.
AsenapineThe risk or severity of adverse effects can be increased when Pregabalin is combined with Asenapine.
AtosibanThe risk or severity of adverse effects can be increased when Pregabalin is combined with Atosiban.
Atracurium besylatePregabalin may increase the neuromuscular blocking activities of Atracurium besylate.
AzaperoneThe risk or severity of adverse effects can be increased when Pregabalin is combined with Azaperone.
AzelastinePregabalin may increase the central nervous system depressant (CNS depressant) activities of Azelastine.
AzelastineThe risk or severity of adverse effects can be increased when Azelastine is combined with Pregabalin.
BaclofenThe risk or severity of adverse effects can be increased when Pregabalin is combined with Baclofen.
Bafilomycin A1The risk or severity of adverse effects can be increased when Bafilomycin A1 is combined with Pregabalin.
BarbitalThe metabolism of Pregabalin can be increased when combined with Barbital.
BarbitalThe risk or severity of adverse effects can be increased when Pregabalin is combined with Barbital.
BenazeprilThe risk or severity of adverse effects can be increased when Benazepril is combined with Pregabalin.
BenzocaineThe risk or severity of adverse effects can be increased when Pregabalin is combined with Benzocaine.
Benzoic AcidThe risk or severity of adverse effects can be increased when Benzoic Acid is combined with Pregabalin.
Benzyl alcoholThe risk or severity of adverse effects can be increased when Pregabalin is combined with Benzyl alcohol.
BifonazoleThe risk or severity of adverse effects can be increased when Bifonazole is combined with Pregabalin.
BrexpiprazoleThe risk or severity of adverse effects can be increased when Pregabalin is combined with Brexpiprazole.
BrimonidineBrimonidine may increase the central nervous system depressant (CNS depressant) activities of Pregabalin.
BrimonidineThe risk or severity of adverse effects can be increased when Pregabalin is combined with Brimonidine.
BromazepamThe risk or severity of adverse effects can be increased when Pregabalin is combined with Bromazepam.
BrompheniramineThe risk or severity of adverse effects can be increased when Pregabalin is combined with Brompheniramine.
BrotizolamThe risk or severity of adverse effects can be increased when Pregabalin is combined with Brotizolam.
BupivacaineThe risk or severity of adverse effects can be increased when Pregabalin is combined with Bupivacaine.
BuprenorphineThe risk or severity of adverse effects can be increased when Pregabalin is combined with Buprenorphine.
BuspironeThe risk or severity of adverse effects can be increased when Pregabalin is combined with Buspirone.
ButabarbitalThe risk or severity of adverse effects can be increased when Pregabalin is combined with Butabarbital.
ButacaineThe risk or severity of adverse effects can be increased when Pregabalin is combined with Butacaine.
ButalbitalThe risk or severity of adverse effects can be increased when Pregabalin is combined with Butalbital.
ButambenThe risk or severity of adverse effects can be increased when Pregabalin is combined with Butamben.
ButenafineThe risk or severity of adverse effects can be increased when Butenafine is combined with Pregabalin.
ButethalThe risk or severity of adverse effects can be increased when Pregabalin is combined with Butethal.
ButoconazoleThe risk or severity of adverse effects can be increased when Butoconazole is combined with Pregabalin.
ButorphanolThe risk or severity of adverse effects can be increased when Pregabalin is combined with Butorphanol.
CandicidinThe risk or severity of adverse effects can be increased when Candicidin is combined with Pregabalin.
CandoxatrilThe risk or severity of adverse effects can be increased when Candoxatril is combined with Pregabalin.
CaptoprilThe risk or severity of adverse effects can be increased when Captopril is combined with Pregabalin.
CarbamazepineThe risk or severity of adverse effects can be increased when Pregabalin is combined with Carbamazepine.
CarbinoxamineThe risk or severity of adverse effects can be increased when Pregabalin is combined with Carbinoxamine.
CarfentanilThe risk or severity of adverse effects can be increased when Pregabalin is combined with Carfentanil.
CarisoprodolThe risk or severity of adverse effects can be increased when Pregabalin is combined with Carisoprodol.
CarvedilolCarvedilol may increase the hypotensive activities of Pregabalin.
CaspofunginThe risk or severity of adverse effects can be increased when Caspofungin is combined with Pregabalin.
CeruleninThe risk or severity of adverse effects can be increased when Cerulenin is combined with Pregabalin.
CetirizineThe risk or severity of adverse effects can be increased when Pregabalin is combined with Cetirizine.
Chloral hydrateThe risk or severity of adverse effects can be increased when Pregabalin is combined with Chloral hydrate.
ChlordiazepoxideThe risk or severity of adverse effects can be increased when Pregabalin is combined with Chlordiazepoxide.
ChlormezanoneThe risk or severity of adverse effects can be increased when Pregabalin is combined with Chlormezanone.
ChloroprocaineThe risk or severity of adverse effects can be increased when Pregabalin is combined with Chloroprocaine.
ChloroxineThe risk or severity of adverse effects can be increased when Chloroxine is combined with Pregabalin.
ChlorphenamineThe risk or severity of adverse effects can be increased when Pregabalin is combined with Chlorphenamine.
ChlorpromazineThe risk or severity of adverse effects can be increased when Pregabalin is combined with Chlorpromazine.
ChlorprothixeneThe risk or severity of adverse effects can be increased when Pregabalin is combined with Chlorprothixene.
ChlorzoxazoneThe risk or severity of adverse effects can be increased when Pregabalin is combined with Chlorzoxazone.
CiclopiroxThe risk or severity of adverse effects can be increased when Ciclopirox is combined with Pregabalin.
CilazaprilThe risk or severity of adverse effects can be increased when Cilazapril is combined with Pregabalin.
CimetidineThe serum concentration of Pregabalin can be increased when it is combined with Cimetidine.
CinchocaineThe risk or severity of adverse effects can be increased when Pregabalin is combined with Cinchocaine.
CitalopramThe risk or severity of adverse effects can be increased when Pregabalin is combined with Citalopram.
ClemastineThe risk or severity of adverse effects can be increased when Pregabalin is combined with Clemastine.
ClidiniumThe risk or severity of adverse effects can be increased when Pregabalin is combined with Clidinium.
ClobazamThe risk or severity of adverse effects can be increased when Pregabalin is combined with Clobazam.
clomethiazoleThe risk or severity of adverse effects can be increased when Pregabalin is combined with clomethiazole.
ClomipramineThe risk or severity of adverse effects can be increased when Pregabalin is combined with Clomipramine.
ClonazepamThe risk or severity of adverse effects can be increased when Pregabalin is combined with Clonazepam.
ClonidineThe risk or severity of adverse effects can be increased when Pregabalin is combined with Clonidine.
ClopidogrelThe therapeutic efficacy of Clopidogrel can be decreased when used in combination with Pregabalin.
ClorazepateThe risk or severity of adverse effects can be increased when Pregabalin is combined with Clorazepate.
ClotrimazoleThe risk or severity of adverse effects can be increased when Clotrimazole is combined with Pregabalin.
ClozapineThe risk or severity of adverse effects can be increased when Pregabalin is combined with Clozapine.
CocaineThe risk or severity of adverse effects can be increased when Pregabalin is combined with Cocaine.
CodeineThe risk or severity of adverse effects can be increased when Pregabalin is combined with Codeine.
CyclizineThe risk or severity of adverse effects can be increased when Pregabalin is combined with Cyclizine.
CyclobenzaprineThe risk or severity of adverse effects can be increased when Pregabalin is combined with Cyclobenzaprine.
CyclosporineThe risk or severity of adverse effects can be increased when Cyclosporine is combined with Pregabalin.
CyproheptadineThe risk or severity of adverse effects can be increased when Pregabalin is combined with Cyproheptadine.
DantroleneThe risk or severity of adverse effects can be increased when Pregabalin is combined with Dantrolene.
DapiprazoleThe risk or severity of adverse effects can be increased when Pregabalin is combined with Dapiprazole.
DapoxetineDapoxetine may increase the orthostatic hypotensive activities of Pregabalin.
DapoxetineThe risk or severity of adverse effects can be increased when Pregabalin is combined with Dapoxetine.
Decanoic AcidThe risk or severity of adverse effects can be increased when Decanoic Acid is combined with Pregabalin.
deramciclaneThe risk or severity of adverse effects can be increased when Pregabalin is combined with deramciclane.
DesfluraneThe risk or severity of adverse effects can be increased when Pregabalin is combined with Desflurane.
DesipramineThe risk or severity of adverse effects can be increased when Pregabalin is combined with Desipramine.
DesloratadineThe risk or severity of adverse effects can be increased when Pregabalin is combined with Desloratadine.
DetomidineThe risk or severity of adverse effects can be increased when Pregabalin is combined with Detomidine.
DexbrompheniramineThe risk or severity of adverse effects can be increased when Pregabalin is combined with Dexbrompheniramine.
DexmedetomidineThe risk or severity of adverse effects can be increased when Pregabalin is combined with Dexmedetomidine.
DextromoramideThe risk or severity of adverse effects can be increased when Pregabalin is combined with Dextromoramide.
DextropropoxypheneThe risk or severity of adverse effects can be increased when Pregabalin is combined with Dextropropoxyphene.
DezocineThe risk or severity of adverse effects can be increased when Pregabalin is combined with Dezocine.
DiazepamThe risk or severity of adverse effects can be increased when Pregabalin is combined with Diazepam.
DifenoxinThe risk or severity of adverse effects can be increased when Pregabalin is combined with Difenoxin.
DihydrocodeineThe risk or severity of adverse effects can be increased when Pregabalin is combined with Dihydrocodeine.
DihydroetorphineThe risk or severity of adverse effects can be increased when Pregabalin is combined with Dihydroetorphine.
DihydromorphineThe risk or severity of adverse effects can be increased when Pregabalin is combined with Dihydromorphine.
DimenhydrinateThe risk or severity of adverse effects can be increased when Pregabalin is combined with Dimenhydrinate.
DiphenhydramineThe risk or severity of adverse effects can be increased when Pregabalin is combined with Diphenhydramine.
DiphenoxylateThe risk or severity of adverse effects can be increased when Pregabalin is combined with Diphenoxylate.
DoramectinThe risk or severity of adverse effects can be increased when Pregabalin is combined with Doramectin.
DoxazosinDoxazosin may increase the hypotensive activities of Pregabalin.
DoxepinThe risk or severity of adverse effects can be increased when Pregabalin is combined with Doxepin.
DoxylamineDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Pregabalin.
DoxylamineThe risk or severity of adverse effects can be increased when Pregabalin is combined with Doxylamine.
DPDPEThe risk or severity of adverse effects can be increased when Pregabalin is combined with DPDPE.
DronabinolDronabinol may increase the central nervous system depressant (CNS depressant) activities of Pregabalin.
DroperidolThe risk or severity of adverse effects can be increased when Pregabalin is combined with Droperidol.
DrotebanolThe risk or severity of adverse effects can be increased when Pregabalin is combined with Drotebanol.
DyclonineThe risk or severity of adverse effects can be increased when Pregabalin is combined with Dyclonine.
EcgonineThe risk or severity of adverse effects can be increased when Pregabalin is combined with Ecgonine.
ECGONINE METHYL ESTERThe risk or severity of adverse effects can be increased when Pregabalin is combined with ECGONINE METHYL ESTER.
EconazoleThe risk or severity of adverse effects can be increased when Econazole is combined with Pregabalin.
EfavirenzThe serum concentration of Pregabalin can be decreased when it is combined with Efavirenz.
EfavirenzThe risk or severity of adverse effects can be increased when Pregabalin is combined with Efavirenz.
EfinaconazoleThe risk or severity of adverse effects can be increased when Efinaconazole is combined with Pregabalin.
EnalaprilThe risk or severity of adverse effects can be increased when Enalapril is combined with Pregabalin.
EnalaprilatThe risk or severity of adverse effects can be increased when Enalaprilat is combined with Pregabalin.
EnfluraneThe risk or severity of adverse effects can be increased when Enflurane is combined with Pregabalin.
EntacaponeThe risk or severity of adverse effects can be increased when Pregabalin is combined with Entacapone.
EscitalopramThe risk or severity of adverse effects can be increased when Pregabalin is combined with Escitalopram.
EstazolamThe risk or severity of adverse effects can be increased when Pregabalin is combined with Estazolam.
EszopicloneThe risk or severity of adverse effects can be increased when Pregabalin is combined with Eszopiclone.
EthanolPregabalin may increase the central nervous system depressant (CNS depressant) activities of Ethanol.
EthanolThe risk or severity of adverse effects can be increased when Ethanol is combined with Pregabalin.
EthchlorvynolThe risk or severity of adverse effects can be increased when Ethchlorvynol is combined with Pregabalin.
EthosuximideThe risk or severity of adverse effects can be increased when Pregabalin is combined with Ethosuximide.
EthotoinThe risk or severity of adverse effects can be increased when Pregabalin is combined with Ethotoin.
Ethyl carbamateThe risk or severity of adverse effects can be increased when Pregabalin is combined with Ethyl carbamate.
Ethyl loflazepateThe risk or severity of adverse effects can be increased when Pregabalin is combined with Ethyl loflazepate.
EthylmorphineThe risk or severity of adverse effects can be increased when Pregabalin is combined with Ethylmorphine.
EtidocaineThe risk or severity of adverse effects can be increased when Pregabalin is combined with Etidocaine.
EtifoxineThe risk or severity of adverse effects can be increased when Pregabalin is combined with Etifoxine.
EtizolamThe risk or severity of adverse effects can be increased when Pregabalin is combined with Etizolam.
EtomidateThe risk or severity of adverse effects can be increased when Pregabalin is combined with Etomidate.
EtoperidoneThe risk or severity of adverse effects can be increased when Pregabalin is combined with Etoperidone.
EtorphineThe risk or severity of adverse effects can be increased when Pregabalin is combined with Etorphine.
EzogabineThe risk or severity of adverse effects can be increased when Pregabalin is combined with Ezogabine.
FelbamateThe risk or severity of adverse effects can be increased when Pregabalin is combined with Felbamate.
FencamfamineThe risk or severity of adverse effects can be increased when Pregabalin is combined with Fencamfamine.
FenfluramineThe risk or severity of adverse effects can be increased when Pregabalin is combined with Fenfluramine.
FentanylThe risk or severity of adverse effects can be increased when Pregabalin is combined with Fentanyl.
FexofenadineThe risk or severity of adverse effects can be increased when Pregabalin is combined with Fexofenadine.
FlibanserinThe risk or severity of adverse effects can be increased when Pregabalin is combined with Flibanserin.
FluconazoleThe serum concentration of Pregabalin can be increased when it is combined with Fluconazole.
FlucytosineThe risk or severity of adverse effects can be increased when Flucytosine is combined with Pregabalin.
FludiazepamThe risk or severity of adverse effects can be increased when Pregabalin is combined with Fludiazepam.
FlunarizineThe risk or severity of adverse effects can be increased when Pregabalin is combined with Flunarizine.
FlunitrazepamThe risk or severity of adverse effects can be increased when Pregabalin is combined with Flunitrazepam.
FluoxetineThe risk or severity of adverse effects can be increased when Pregabalin is combined with Fluoxetine.
FlupentixolThe risk or severity of adverse effects can be increased when Pregabalin is combined with Flupentixol.
FluphenazineThe risk or severity of adverse effects can be increased when Pregabalin is combined with Fluphenazine.
FlurazepamThe risk or severity of adverse effects can be increased when Pregabalin is combined with Flurazepam.
FluspirileneThe risk or severity of adverse effects can be increased when Pregabalin is combined with Fluspirilene.
Fluticasone PropionateThe risk or severity of adverse effects can be increased when Pregabalin is combined with Fluticasone Propionate.
FluvoxamineThe risk or severity of adverse effects can be increased when Pregabalin is combined with Fluvoxamine.
FosinoprilThe risk or severity of adverse effects can be increased when Fosinopril is combined with Pregabalin.
FosphenytoinThe risk or severity of adverse effects can be increased when Pregabalin is combined with Fosphenytoin.
FospropofolThe risk or severity of adverse effects can be increased when Pregabalin is combined with Fospropofol.
GabapentinThe risk or severity of adverse effects can be increased when Pregabalin is combined with Gabapentin.
gabapentin enacarbilThe risk or severity of adverse effects can be increased when Pregabalin is combined with gabapentin enacarbil.
Gamma Hydroxybutyric AcidThe risk or severity of adverse effects can be increased when Pregabalin is combined with Gamma Hydroxybutyric Acid.
GlutethimideThe risk or severity of adverse effects can be increased when Pregabalin is combined with Glutethimide.
GlyphosateThe risk or severity of adverse effects can be increased when Glyphosate is combined with Pregabalin.
GriseofulvinThe risk or severity of adverse effects can be increased when Griseofulvin is combined with Pregabalin.
GuanfacineThe risk or severity of adverse effects can be increased when Pregabalin is combined with Guanfacine.
HalazepamThe risk or severity of adverse effects can be increased when Pregabalin is combined with Halazepam.
HaloperidolThe risk or severity of adverse effects can be increased when Pregabalin is combined with Haloperidol.
HaloproginThe risk or severity of adverse effects can be increased when Haloprogin is combined with Pregabalin.
HalothaneThe risk or severity of adverse effects can be increased when Pregabalin is combined with Halothane.
HeroinThe risk or severity of adverse effects can be increased when Pregabalin is combined with Heroin.
HexetidineThe risk or severity of adverse effects can be increased when Hexetidine is combined with Pregabalin.
HexobarbitalThe metabolism of Pregabalin can be increased when combined with Hexobarbital.
HexobarbitalThe risk or severity of adverse effects can be increased when Pregabalin is combined with Hexobarbital.
HydrocodoneThe risk or severity of adverse effects can be increased when Pregabalin is combined with Hydrocodone.
HydromorphoneThe risk or severity of adverse effects can be increased when Pregabalin is combined with Hydromorphone.
HydroxyzineHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Pregabalin.
HydroxyzineThe risk or severity of adverse effects can be increased when Pregabalin is combined with Hydroxyzine.
IloperidoneThe risk or severity of adverse effects can be increased when Pregabalin is combined with Iloperidone.
ImipramineThe risk or severity of adverse effects can be increased when Pregabalin is combined with Imipramine.
IndalpineThe risk or severity of adverse effects can be increased when Pregabalin is combined with Indalpine.
IndoraminIndoramin may increase the hypotensive activities of Pregabalin.
IsoconazoleThe risk or severity of adverse effects can be increased when Isoconazole is combined with Pregabalin.
IsofluraneThe risk or severity of adverse effects can be increased when Pregabalin is combined with Isoflurane.
ItraconazoleThe risk or severity of adverse effects can be increased when Itraconazole is combined with Pregabalin.
KetamineThe risk or severity of adverse effects can be increased when Pregabalin is combined with Ketamine.
KetazolamThe risk or severity of adverse effects can be increased when Pregabalin is combined with Ketazolam.
KetobemidoneThe risk or severity of adverse effects can be increased when Pregabalin is combined with Ketobemidone.
KetoconazoleThe risk or severity of adverse effects can be increased when Ketoconazole is combined with Pregabalin.
LabetalolLabetalol may increase the hypotensive activities of Pregabalin.
LamotrigineThe risk or severity of adverse effects can be increased when Pregabalin is combined with Lamotrigine.
LevetiracetamThe risk or severity of adverse effects can be increased when Pregabalin is combined with Levetiracetam.
LevobupivacaineThe risk or severity of adverse effects can be increased when Pregabalin is combined with Levobupivacaine.
LevocabastineThe risk or severity of adverse effects can be increased when Pregabalin is combined with Levocabastine.
LevocetirizineThe risk or severity of adverse effects can be increased when Pregabalin is combined with Levocetirizine.
LevodopaThe risk or severity of adverse effects can be increased when Pregabalin is combined with Levodopa.
Levomethadyl AcetateThe risk or severity of adverse effects can be increased when Pregabalin is combined with Levomethadyl Acetate.
LevomilnacipranThe risk or severity of adverse effects can be increased when Pregabalin is combined with Levomilnacipran.
LevorphanolThe risk or severity of adverse effects can be increased when Pregabalin is combined with Levorphanol.
LidocaineThe risk or severity of adverse effects can be increased when Pregabalin is combined with Lidocaine.
LisinoprilThe risk or severity of adverse effects can be increased when Lisinopril is combined with Pregabalin.
LithiumThe risk or severity of adverse effects can be increased when Pregabalin is combined with Lithium.
LofentanilThe risk or severity of adverse effects can be increased when Pregabalin is combined with Lofentanil.
LoratadineThe risk or severity of adverse effects can be increased when Pregabalin is combined with Loratadine.
LorazepamThe risk or severity of adverse effects can be increased when Lorazepam is combined with Pregabalin.
LoxapineThe risk or severity of adverse effects can be increased when Pregabalin is combined with Loxapine.
Lu AA21004The risk or severity of adverse effects can be increased when Pregabalin is combined with Lu AA21004.
LurasidoneThe risk or severity of adverse effects can be increased when Pregabalin is combined with Lurasidone.
Magnesium hydroxideThe risk or severity of adverse effects can be increased when Pregabalin is combined with Magnesium hydroxide.
Magnesium oxideThe risk or severity of adverse effects can be increased when Pregabalin is combined with Magnesium oxide.
Magnesium salicylateThe risk or severity of adverse effects can be increased when Pregabalin is combined with Magnesium salicylate.
Magnesium SulfateMagnesium Sulfate may increase the central nervous system depressant (CNS depressant) activities of Pregabalin.
Magnesium SulfateThe risk or severity of adverse effects can be increased when Pregabalin is combined with Magnesium Sulfate.
MaprotilineThe risk or severity of adverse effects can be increased when Pregabalin is combined with Maprotiline.
MeclizineThe risk or severity of adverse effects can be increased when Pregabalin is combined with Meclizine.
MedetomidineThe risk or severity of adverse effects can be increased when Pregabalin is combined with Medetomidine.
MefloquineThe therapeutic efficacy of Pregabalin can be decreased when used in combination with Mefloquine.
MelatoninThe risk or severity of adverse effects can be increased when Pregabalin is combined with Melatonin.
MelperoneThe risk or severity of adverse effects can be increased when Pregabalin is combined with Melperone.
MepivacaineThe risk or severity of adverse effects can be increased when Pregabalin is combined with Mepivacaine.
MeprobamateThe risk or severity of adverse effects can be increased when Pregabalin is combined with Meprobamate.
MesoridazineThe risk or severity of adverse effects can be increased when Pregabalin is combined with Mesoridazine.
MetaxaloneThe risk or severity of adverse effects can be increased when Pregabalin is combined with Metaxalone.
MethadoneThe risk or severity of adverse effects can be increased when Pregabalin is combined with Methadone.
Methadyl AcetateThe risk or severity of adverse effects can be increased when Pregabalin is combined with Methadyl Acetate.
MethapyrileneThe risk or severity of adverse effects can be increased when Pregabalin is combined with Methapyrilene.
MethaqualoneThe risk or severity of adverse effects can be increased when Pregabalin is combined with Methaqualone.
MethocarbamolThe risk or severity of adverse effects can be increased when Pregabalin is combined with Methocarbamol.
MethohexitalThe metabolism of Pregabalin can be increased when combined with Methohexital.
MethohexitalThe risk or severity of adverse effects can be increased when Pregabalin is combined with Methohexital.
MethotrimeprazineThe risk or severity of adverse effects can be increased when Pregabalin is combined with Methotrimeprazine.
MethoxyfluraneThe risk or severity of adverse effects can be increased when Pregabalin is combined with Methoxyflurane.
MethsuximideThe risk or severity of adverse effects can be increased when Pregabalin is combined with Methsuximide.
MethylphenobarbitalThe metabolism of Pregabalin can be increased when combined with Methylphenobarbital.
MethylphenobarbitalThe risk or severity of adverse effects can be increased when Pregabalin is combined with Methylphenobarbital.
MetyrosinePregabalin may increase the sedative activities of Metyrosine.
MevastatinThe risk or severity of adverse effects can be increased when Mevastatin is combined with Pregabalin.
MianserinThe therapeutic efficacy of Pregabalin can be decreased when used in combination with Mianserin.
MicafunginThe risk or severity of adverse effects can be increased when Micafungin is combined with Pregabalin.
MiconazoleThe risk or severity of adverse effects can be increased when Miconazole is combined with Pregabalin.
MidazolamThe risk or severity of adverse effects can be increased when Pregabalin is combined with Midazolam.
MilnacipranThe risk or severity of adverse effects can be increased when Pregabalin is combined with Milnacipran.
MiltefosineThe risk or severity of adverse effects can be increased when Miltefosine is combined with Pregabalin.
MinocyclineMinocycline may increase the central nervous system depressant (CNS depressant) activities of Pregabalin.
MirtazapinePregabalin may increase the central nervous system depressant (CNS depressant) activities of Mirtazapine.
MirtazapineThe risk or severity of adverse effects can be increased when Mirtazapine is combined with Pregabalin.
MivacuriumPregabalin may increase the neuromuscular blocking activities of Mivacurium.
MoexiprilThe risk or severity of adverse effects can be increased when Moexipril is combined with Pregabalin.
MolindoneThe risk or severity of adverse effects can be increased when Pregabalin is combined with Molindone.
MonensinThe risk or severity of adverse effects can be increased when Monensin is combined with Pregabalin.
MorphineThe risk or severity of adverse effects can be increased when Pregabalin is combined with Morphine.
MyxothiazolThe risk or severity of adverse effects can be increased when Myxothiazol is combined with Pregabalin.
NabiloneNabilone may increase the central nervous system depressant (CNS depressant) activities of Pregabalin.
NabiloneThe risk or severity of adverse effects can be increased when Pregabalin is combined with Nabilone.
NafcillinThe metabolism of Pregabalin can be increased when combined with Nafcillin.
NaftifineThe risk or severity of adverse effects can be increased when Naftifine is combined with Pregabalin.
NalbuphineThe risk or severity of adverse effects can be increased when Pregabalin is combined with Nalbuphine.
NatamycinThe risk or severity of adverse effects can be increased when Natamycin is combined with Pregabalin.
NitrazepamThe risk or severity of adverse effects can be increased when Pregabalin is combined with Nitrazepam.
NitroprussidePregabalin may increase the hypotensive activities of Nitroprusside.
Nitrous oxideThe risk or severity of adverse effects can be increased when Pregabalin is combined with Nitrous oxide.
NitroxolineThe risk or severity of adverse effects can be increased when Nitroxoline is combined with Pregabalin.
NormethadoneThe risk or severity of adverse effects can be increased when Pregabalin is combined with Normethadone.
NortriptylineThe risk or severity of adverse effects can be increased when Pregabalin is combined with Nortriptyline.
NystatinThe risk or severity of adverse effects can be increased when Nystatin is combined with Pregabalin.
OlanzapineThe risk or severity of adverse effects can be increased when Pregabalin is combined with Olanzapine.
OlopatadineThe risk or severity of adverse effects can be increased when Pregabalin is combined with Olopatadine.
OmapatrilatThe risk or severity of adverse effects can be increased when Omapatrilat is combined with Pregabalin.
OndansetronThe risk or severity of adverse effects can be increased when Pregabalin is combined with Ondansetron.
OpiumThe risk or severity of adverse effects can be increased when Pregabalin is combined with Opium.
OrlistatThe serum concentration of Pregabalin can be decreased when it is combined with Orlistat.
OrphenadrinePregabalin may increase the central nervous system depressant (CNS depressant) activities of Orphenadrine.
OrphenadrineThe risk or severity of adverse effects can be increased when Orphenadrine is combined with Pregabalin.
OsanetantThe risk or severity of adverse effects can be increased when Pregabalin is combined with Osanetant.
OxazepamThe risk or severity of adverse effects can be increased when Pregabalin is combined with Oxazepam.
OxiconazoleThe risk or severity of adverse effects can be increased when Oxiconazole is combined with Pregabalin.
OxprenololThe risk or severity of adverse effects can be increased when Pregabalin is combined with Oxprenolol.
OxybuprocaineThe risk or severity of adverse effects can be increased when Pregabalin is combined with Oxybuprocaine.
OxycodoneThe risk or severity of adverse effects can be increased when Pregabalin is combined with Oxycodone.
OxymorphoneThe risk or severity of adverse effects can be increased when Pregabalin is combined with Oxymorphone.
pafuramidineThe risk or severity of adverse effects can be increased when pafuramidine is combined with Pregabalin.
PaliperidoneThe risk or severity of adverse effects can be increased when Pregabalin is combined with Paliperidone.
ParaldehydePregabalin may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.
ParaldehydeThe risk or severity of adverse effects can be increased when Paraldehyde is combined with Pregabalin.
ParoxetineThe risk or severity of adverse effects can be increased when Pregabalin is combined with Paroxetine.
PentamidineThe risk or severity of adverse effects can be increased when Pentamidine is combined with Pregabalin.
PentazocineThe risk or severity of adverse effects can be increased when Pregabalin is combined with Pentazocine.
PentobarbitalThe metabolism of Pregabalin can be increased when combined with Pentobarbital.
PentobarbitalThe risk or severity of adverse effects can be increased when Pregabalin is combined with Pentobarbital.
PerampanelThe risk or severity of adverse effects can be increased when Pregabalin is combined with Perampanel.
PerindoprilThe risk or severity of adverse effects can be increased when Perindopril is combined with Pregabalin.
PerospironeThe risk or severity of adverse effects can be increased when Pregabalin is combined with Perospirone.
PerphenazineThe risk or severity of adverse effects can be increased when Pregabalin is combined with Perphenazine.
PethidineThe risk or severity of adverse effects can be increased when Pregabalin is combined with Pethidine.
PhenobarbitalThe metabolism of Pregabalin can be increased when combined with Phenobarbital.
PhenobarbitalThe risk or severity of adverse effects can be increased when Pregabalin is combined with Phenobarbital.
PhenoxyethanolThe risk or severity of adverse effects can be increased when Pregabalin is combined with Phenoxyethanol.
PhenytoinThe risk or severity of adverse effects can be increased when Pregabalin is combined with Phenytoin.
PimozideThe risk or severity of adverse effects can be increased when Pregabalin is combined with Pimozide.
PioglitazonePregabalin may increase the fluid retaining activities of Pioglitazone.
PipamperoneThe risk or severity of adverse effects can be increased when Pregabalin is combined with Pipamperone.
PipotiazineThe risk or severity of adverse effects can be increased when Pregabalin is combined with Pipotiazine.
PizotifenThe risk or severity of adverse effects can be increased when Pregabalin is combined with Pizotifen.
PomalidomideThe risk or severity of adverse effects can be increased when Pregabalin is combined with Pomalidomide.
PosaconazoleThe risk or severity of adverse effects can be increased when Posaconazole is combined with Pregabalin.
PramipexolePregabalin may increase the sedative activities of Pramipexole.
PramocaineThe risk or severity of adverse effects can be increased when Pregabalin is combined with Pramocaine.
PrazepamThe risk or severity of adverse effects can be increased when Pregabalin is combined with Prazepam.
PrazosinPrazosin may increase the hypotensive activities of Pregabalin.
PrilocaineThe risk or severity of adverse effects can be increased when Pregabalin is combined with Prilocaine.
PrimidoneThe metabolism of Pregabalin can be increased when combined with Primidone.
PrimidoneThe risk or severity of adverse effects can be increased when Pregabalin is combined with Primidone.
ProcaineThe risk or severity of adverse effects can be increased when Pregabalin is combined with Procaine.
ProchlorperazineThe risk or severity of adverse effects can be increased when Pregabalin is combined with Prochlorperazine.
PromazineThe risk or severity of adverse effects can be increased when Pregabalin is combined with Promazine.
PromethazineThe risk or severity of adverse effects can be increased when Pregabalin is combined with Promethazine.
ProparacaineThe risk or severity of adverse effects can be increased when Pregabalin is combined with Proparacaine.
PropofolThe risk or severity of adverse effects can be increased when Pregabalin is combined with Propofol.
PropoxycaineThe risk or severity of adverse effects can be increased when Pregabalin is combined with Propoxycaine.
ProtriptylineThe risk or severity of adverse effects can be increased when Pregabalin is combined with Protriptyline.
PSD502The risk or severity of adverse effects can be increased when Pregabalin is combined with PSD502.
QuazepamThe risk or severity of adverse effects can be increased when Pregabalin is combined with Quazepam.
QuetiapineThe risk or severity of adverse effects can be increased when Pregabalin is combined with Quetiapine.
QuinaprilThe risk or severity of adverse effects can be increased when Quinapril is combined with Pregabalin.
RadicicolThe risk or severity of adverse effects can be increased when Radicicol is combined with Pregabalin.
RamelteonThe risk or severity of adverse effects can be increased when Pregabalin is combined with Ramelteon.
RamiprilThe risk or severity of adverse effects can be increased when Ramipril is combined with Pregabalin.
RapacuroniumPregabalin may increase the neuromuscular blocking activities of Rapacuronium.
RemifentanilThe risk or severity of adverse effects can be increased when Pregabalin is combined with Remifentanil.
RemoxiprideThe risk or severity of adverse effects can be increased when Pregabalin is combined with Remoxipride.
RescinnamineThe risk or severity of adverse effects can be increased when Rescinnamine is combined with Pregabalin.
ReserpineThe risk or severity of adverse effects can be increased when Reserpine is combined with Pregabalin.
RisperidoneThe risk or severity of adverse effects can be increased when Pregabalin is combined with Risperidone.
RomifidineThe risk or severity of adverse effects can be increased when Pregabalin is combined with Romifidine.
RopinirolePregabalin may increase the sedative activities of Ropinirole.
RopivacaineThe risk or severity of adverse effects can be increased when Pregabalin is combined with Ropivacaine.
RosiglitazonePregabalin may increase the fluid retaining activities of Rosiglitazone.
RotigotinePregabalin may increase the sedative activities of Rotigotine.
RufinamideThe risk or severity of adverse effects can be increased when Rufinamide is combined with Pregabalin.
S-EthylisothioureaThe risk or severity of adverse effects can be increased when Pregabalin is combined with S-Ethylisothiourea.
Salicylhydroxamic AcidThe risk or severity of adverse effects can be increased when Salicylhydroxamic Acid is combined with Pregabalin.
Salicylic acidThe risk or severity of adverse effects can be increased when Salicylic acid is combined with Pregabalin.
ScopolamineThe risk or severity of adverse effects can be increased when Pregabalin is combined with Scopolamine.
SecobarbitalThe metabolism of Pregabalin can be increased when combined with Secobarbital.
SecobarbitalThe risk or severity of adverse effects can be increased when Pregabalin is combined with Secobarbital.
SertaconazoleThe risk or severity of adverse effects can be increased when Sertaconazole is combined with Pregabalin.
SertindoleThe risk or severity of adverse effects can be increased when Pregabalin is combined with Sertindole.
SertralineThe risk or severity of adverse effects can be increased when Pregabalin is combined with Sertraline.
SevofluraneThe risk or severity of adverse effects can be increased when Pregabalin is combined with Sevoflurane.
SilodosinSilodosin may increase the hypotensive activities of Pregabalin.
SinefunginThe risk or severity of adverse effects can be increased when Sinefungin is combined with Pregabalin.
SirolimusThe risk or severity of adverse effects can be increased when Sirolimus is combined with Pregabalin.
Sodium oxybateThe risk or severity of adverse effects can be increased when Pregabalin is combined with Sodium oxybate.
SpiraprilThe risk or severity of adverse effects can be increased when Spirapril is combined with Pregabalin.
StiripentolThe risk or severity of adverse effects can be increased when Pregabalin is combined with Stiripentol.
SufentanilThe risk or severity of adverse effects can be increased when Pregabalin is combined with Sufentanil.
SulconazoleThe risk or severity of adverse effects can be increased when Sulconazole is combined with Pregabalin.
SulpirideThe risk or severity of adverse effects can be increased when Pregabalin is combined with Sulpiride.
SuvorexantThe risk or severity of adverse effects can be increased when Pregabalin is combined with Suvorexant.
TamsulosinTamsulosin may increase the hypotensive activities of Pregabalin.
TapentadolThe risk or severity of adverse effects can be increased when Pregabalin is combined with Tapentadol.
TasimelteonThe risk or severity of adverse effects can be increased when Pregabalin is combined with Tasimelteon.
TavaboroleThe risk or severity of adverse effects can be increased when Tavaborole is combined with Pregabalin.
TemazepamThe risk or severity of adverse effects can be increased when Pregabalin is combined with Temazepam.
TemocaprilThe risk or severity of adverse effects can be increased when Temocapril is combined with Pregabalin.
TerazosinTerazosin may increase the hypotensive activities of Pregabalin.
TerbinafineThe risk or severity of adverse effects can be increased when Terbinafine is combined with Pregabalin.
TerconazoleThe risk or severity of adverse effects can be increased when Terconazole is combined with Pregabalin.
TetrabenazineThe risk or severity of adverse effects can be increased when Pregabalin is combined with Tetrabenazine.
TetracaineThe risk or severity of adverse effects can be increased when Pregabalin is combined with Tetracaine.
TetrodotoxinThe risk or severity of adverse effects can be increased when Pregabalin is combined with Tetrodotoxin.
ThalidomidePregabalin may increase the central nervous system depressant (CNS depressant) activities of Thalidomide.
ThalidomideThe risk or severity of adverse effects can be increased when Thalidomide is combined with Pregabalin.
ThiamylalThe metabolism of Pregabalin can be increased when combined with Thiamylal.
ThiamylalThe risk or severity of adverse effects can be increased when Pregabalin is combined with Thiamylal.
ThiopentalThe metabolism of Pregabalin can be increased when combined with Thiopental.
ThiopentalThe risk or severity of adverse effects can be increased when Pregabalin is combined with Thiopental.
ThioridazineThe risk or severity of adverse effects can be increased when Pregabalin is combined with Thioridazine.
ThiothixeneThe risk or severity of adverse effects can be increased when Pregabalin is combined with Thiothixene.
ThymolThe risk or severity of adverse effects can be increased when Thymol is combined with Pregabalin.
TiagabineThe risk or severity of adverse effects can be increased when Pregabalin is combined with Tiagabine.
TiletamineThe risk or severity of adverse effects can be increased when Pregabalin is combined with Tiletamine.
TioconazoleThe risk or severity of adverse effects can be increased when Tioconazole is combined with Pregabalin.
TizanidineThe risk or severity of adverse effects can be increased when Pregabalin is combined with Tizanidine.
TolcaponeThe risk or severity of adverse effects can be increased when Pregabalin is combined with Tolcapone.
TolnaftateThe risk or severity of adverse effects can be increased when Tolnaftate is combined with Pregabalin.
TopiramateThe risk or severity of adverse effects can be increased when Pregabalin is combined with Topiramate.
TramadolThe risk or severity of adverse effects can be increased when Tramadol is combined with Pregabalin.
TrandolaprilThe risk or severity of adverse effects can be increased when Trandolapril is combined with Pregabalin.
Trans-2-PhenylcyclopropylamineThe risk or severity of adverse effects can be increased when Pregabalin is combined with Trans-2-Phenylcyclopropylamine.
TranylcypromineThe risk or severity of adverse effects can be increased when Pregabalin is combined with Tranylcypromine.
TrazodoneThe risk or severity of adverse effects can be increased when Pregabalin is combined with Trazodone.
TriazolamThe risk or severity of adverse effects can be increased when Pregabalin is combined with Triazolam.
TrifluoperazineThe risk or severity of adverse effects can be increased when Pregabalin is combined with Trifluoperazine.
TriflupromazineThe risk or severity of adverse effects can be increased when Pregabalin is combined with Triflupromazine.
TrimazosinTrimazosin may increase the hypotensive activities of Pregabalin.
TrimetrexateThe risk or severity of adverse effects can be increased when Trimetrexate is combined with Pregabalin.
TrimipramineThe risk or severity of adverse effects can be increased when Pregabalin is combined with Trimipramine.
TriprolidineThe risk or severity of adverse effects can be increased when Pregabalin is combined with Triprolidine.
TroglitazonePregabalin may increase the fluid retaining activities of Troglitazone.
Valproic AcidThe risk or severity of adverse effects can be increased when Pregabalin is combined with Valproic Acid.
VigabatrinThe risk or severity of adverse effects can be increased when Pregabalin is combined with Vigabatrin.
VilazodoneThe risk or severity of adverse effects can be increased when Pregabalin is combined with Vilazodone.
VoriconazoleThe risk or severity of adverse effects can be increased when Voriconazole is combined with Pregabalin.
VortioxetineThe risk or severity of adverse effects can be increased when Pregabalin is combined with Vortioxetine.
XylazineThe risk or severity of adverse effects can be increased when Pregabalin is combined with Xylazine.
YohimbineThe therapeutic efficacy of Pregabalin can be decreased when used in combination with Yohimbine.
ZaleplonThe risk or severity of adverse effects can be increased when Pregabalin is combined with Zaleplon.
ZiconotideThe risk or severity of adverse effects can be increased when Pregabalin is combined with Ziconotide.
ZimelidineThe risk or severity of adverse effects can be increased when Pregabalin is combined with Zimelidine.
ZiprasidoneThe risk or severity of adverse effects can be increased when Pregabalin is combined with Ziprasidone.
ZolazepamThe risk or severity of adverse effects can be increased when Pregabalin is combined with Zolazepam.
ZolpidemThe risk or severity of adverse effects can be increased when Pregabalin is combined with Zolpidem.
ZonisamideThe risk or severity of adverse effects can be increased when Pregabalin is combined with Zonisamide.
ZopicloneThe risk or severity of adverse effects can be increased when Pregabalin is combined with Zopiclone.
ZotepineThe risk or severity of adverse effects can be increased when Pregabalin is combined with Zotepine.
ZuclopenthixolThe risk or severity of adverse effects can be increased when Pregabalin is combined with Zuclopenthixol.
Food Interactions
  • Avoid alcohol (may increase CNS effects).
  • When taken with food, Cmax decreases, while Tmax is prolonged. Despite these observations, the total absorption of pregabalin is not effected to a clinically relevant degree. Pregabalin can be taken with or without food.

Targets

Kind
Protein
Organism
Human
Pharmacological action
yes
Actions
inhibitor
General Function:
Voltage-gated calcium channel activity
Specific Function:
Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1A gives rise to P and/or Q-type calcium currents. P/Q-type calcium channels belong to...
Gene Name:
CACNA1A
Uniprot ID:
O00555
Molecular Weight:
282362.39 Da
References
  1. Gazulla J, Tintore M: The P/Q-type voltage-dependent calcium channel: a therapeutic target in spinocerebellar ataxia type 6. Acta Neurol Scand. 2007 May;115(5):356-63. [PubMed:17489948 ]
  2. Gazulla J, Tintore MA: The P/Q-type voltage-dependent calcium channel as pharmacological target in spinocerebellar ataxia type 6: gabapentin and pregabalin may be of therapeutic benefit. Med Hypotheses. 2007;68(1):131-6. Epub 2006 Aug 8. [PubMed:16899342 ]
  3. Jacquy J, Lossignol D, Sternon J: [Pregabalin (Lyrica) and neuropathic pain syndromes]. Rev Med Brux. 2006 Sep-Oct;27(5):445-50. [PubMed:17144644 ]
  4. Taylor CP, Angelotti T, Fauman E: Pharmacology and mechanism of action of pregabalin: the calcium channel alpha2-delta (alpha2-delta) subunit as a target for antiepileptic drug discovery. Epilepsy Res. 2007 Feb;73(2):137-50. Epub 2006 Nov 28. [PubMed:17126531 ]
  5. Field MJ, Cox PJ, Stott E, Melrose H, Offord J, Su TZ, Bramwell S, Corradini L, England S, Winks J, Kinloch RA, Hendrich J, Dolphin AC, Webb T, Williams D: Identification of the alpha2-delta-1 subunit of voltage-dependent calcium channels as a molecular target for pain mediating the analgesic actions of pregabalin. Proc Natl Acad Sci U S A. 2006 Nov 14;103(46):17537-42. Epub 2006 Nov 6. [PubMed:17088553 ]

Transporters

Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
Other
General Function:
Sodium:dicarboxylate symporter activity
Specific Function:
Transports L-glutamate, L- and D-aspartate and L-cystein (PubMed:21123949). Essential for terminating the postsynaptic action of glutamate by rapidly removing released glutamate from the synaptic cleft. Acts as a symport by cotransporting sodium. Negatively regulated by ARL6IP5 (By similarity).
Gene Name:
SLC1A1
Uniprot ID:
P43005
Molecular Weight:
57099.835 Da
References
  1. Ryu JH, Lee PB, Kim JH, Do SH, Kim CS: Effects of pregabalin on the activity of glutamate transporter type 3. Br J Anaesth. 2012 Aug;109(2):234-9. doi: 10.1093/bja/aes120. Epub 2012 Apr 16. [PubMed:22511482 ]
Comments
comments powered by Disqus
Drug created on June 13, 2005 07:24 / Updated on September 30, 2016 02:26