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Identification
NameNevirapine
Accession NumberDB00238  (APRD00705, DB08311)
TypeSmall Molecule
GroupsApproved
Description

A potent, non-nucleoside reverse transcriptase inhibitor (NNRTI) used in combination with nucleoside analogues for treatment of Human Immunodeficiency Virus Type 1 (HIV-1) infection and AIDS. [PubChem] Structurally, nevirapine belongs to the dipyridodiazepinone chemical class.

Structure
Thumb
Synonyms
11-Cyclopropyl-5,11-dihydro-4-methyl-6H-dipyrido(3,2-b:2',3'-e)(1,4)diazepin-6-one
NEV
Nevirapine
NVP
Viramune
External Identifiers Not Available
Approved Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Auro-nevirapinetablet200 mgoralAurobindo Pharma Limited (Unit Iii)2010-12-29Not applicableCanada
Mylan-nevirapinetablet200 mgoralMylan Pharmaceuticals Ulc2012-06-20Not applicableCanada
Nevirapinesuspension50 mg/5mLoralRoxane Laboratories, Inc.2012-05-21Not applicableUs
Nevirapinetablet200 mg/1oralRoxane Laboratories, Inc.2012-05-21Not applicableUs
PMS-nevirapinetablet200 mgoralPharmascience Inc2013-06-03Not applicableCanada
Teva-nevirapinetablet200 mgoralTeva Canada Limited2011-02-01Not applicableCanada
Viramunetablet200 mg/1oralState of Florida DOH Central Pharmacy2009-07-01Not applicableUs
Viramunetablet, extended release100 mg/1oralBoehringer Ingelheim Pharmaceuticals, Inc.2013-03-01Not applicableUs
Viramunetablet, extended release400 mg/1oralBoehringer Ingelheim Pharmaceuticals, Inc.2011-04-11Not applicableUs
Viramunesuspension50 mg/5mLoralBoehringer Ingelheim Pharmaceuticals Inc.2001-10-01Not applicableUs
Viramunetablet200 mg/1oralBoehringer Ingelheim Pharmaceuticals Inc.2001-08-01Not applicableUs
Viramunetablet200 mgoralBoehringer Ingelheim (Canada) Ltd Ltee1998-09-17Not applicableCanada
Viramunetablet200 mg/1oralA S Medication Solutions2001-08-01Not applicableUs
Viramunetablet, extended release400 mg/1oralPhysicians Total Care, Inc.2013-01-23Not applicableUs
Viramune XRtablet (extended-release)400 mgoralBoehringer Ingelheim (Canada) Ltd Ltee2011-09-27Not applicableCanada
Approved Generic Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Apo-nevirapinetablet200 mgoralApotex IncNot applicableNot applicableCanada
Apo-nevirapine XRtablet (extended-release)400 mgoralApotex Inc2015-11-24Not applicableCanada
Nevirapinetablet200 mg/1oralApotex Corp2012-05-22Not applicableUs
Nevirapinetablet, coated200 mg/1oralCarlsbad Technology, Inc.2016-01-01Not applicableUs
Nevirapinetablet200 mg/1oralMylan Pharmaceuticals Inc.2012-05-22Not applicableUs
Nevirapinetablet200 mg/1oralGolden State Medical Supply, Inc.2012-05-22Not applicableUs
Nevirapinetablet, extended release400 mg/1oralCipla USA Inc.2015-10-15Not applicableUs
Nevirapinetablet200 mg/1oralAlvogen Inc.2012-05-22Not applicableUs
Nevirapinetablet200 mg/1oralState of Florida DOH Central Pharmacy2014-11-01Not applicableUs
Nevirapinetablet200 mg/1oralCamber Pharmaceuticals, Inc.2012-05-23Not applicableUs
Nevirapinetablet200 mg/1oralState of Florida DOH Central Pharmacy2013-01-01Not applicableUs
Nevirapinetablet, extended release400 mg/1oralSandoz Inc2014-04-15Not applicableUs
Nevirapinetablet200 mg/1oralAmneal Agila, Llc2014-04-30Not applicableUs
Nevirapinetablet200 mg/1oralAurobindo Pharma Limited2012-05-22Not applicableUs
Nevirapinetablet, extended release100 mg/1oralMylan Pharmaceuticals Inc.2015-11-09Not applicableUs
Nevirapinetablet200 mg/1oralCipla Limited2012-05-22Not applicableUs
Nevirapinetablet, extended release400 mg/1oralApotex Corp2014-04-15Not applicableUs
Nevirapinetablet200 mg/1oralAmneal Pharmaceuticals of New York, LLC2014-04-30Not applicableUs
Nevirapinetablet, extended release400 mg/1oralMylan Pharmaceuticals Inc.2014-10-29Not applicableUs
Nevirapinetablet200 mg/1oralBreckenridge Pharmaceutical, Inc.2011-04-11Not applicableUs
Nevirapine Extended Releasetablet400 mg/1oralAlvogen Inc.2015-07-14Not applicableUs
Approved Over the Counter ProductsNot Available
Unapproved/Other Products Not Available
International BrandsNot Available
Brand mixtures
NameLabellerIngredients
Apo-zidovudine-lamivudine-nevirapineApotex Inc
SaltsNot Available
Categories
UNII99DK7FVK1H
CAS number129618-40-2
WeightAverage: 266.2979
Monoisotopic: 266.11676109
Chemical FormulaC15H14N4O
InChI KeyInChIKey=NQDJXKOVJZTUJA-UHFFFAOYSA-N
InChI
InChI=1S/C15H14N4O/c1-9-6-8-17-14-12(9)18-15(20)11-3-2-7-16-13(11)19(14)10-4-5-10/h2-3,6-8,10H,4-5H2,1H3,(H,18,20)
IUPAC Name
2-cyclopropyl-7-methyl-2,4,9,15-tetraazatricyclo[9.4.0.0³,⁸]pentadeca-1(11),3,5,7,12,14-hexaen-10-one
SMILES
CC1=C2NC(=O)C3=C(N=CC=C3)N(C3CC3)C2=NC=C1
Taxonomy
DescriptionThis compound belongs to the class of organic compounds known as alkyldiarylamines. These are tertiary alkylarylamines having two aryl and one alkyl groups attached to the amino group.
KingdomOrganic compounds
Super ClassOrganonitrogen compounds
ClassAmines
Sub ClassTertiary amines
Direct ParentAlkyldiarylamines
Alternative Parents
Substituents
  • Alkyldiarylamine
  • Pyrido-para-diazepine
  • Methylpyridine
  • Para-diazepine
  • Imidolactam
  • Pyridine
  • Heteroaromatic compound
  • Vinylogous amide
  • Secondary carboxylic acid amide
  • Lactam
  • Carboxamide group
  • Azacycle
  • Organoheterocyclic compound
  • Carboxylic acid derivative
  • Hydrocarbon derivative
  • Organooxygen compound
  • Carbonyl group
  • Aromatic heteropolycyclic compound
Molecular FrameworkAromatic heteropolycyclic compounds
External Descriptors
Pharmacology
IndicationFor use in combination with other antiretroviral drugs in the ongoing treatment of HIV-1 infection.
PharmacodynamicsNevirapine is a non-nucleoside reverse transcriptase inhibitor (nNRTI) with activity against Human Immunodeficiency Virus Type 1 (HIV-1). HIV-2 RT and eukaryotic DNA polymerases (such as human DNA polymerases alpha, beta, or sigma) are not inhibited by nevirapine. Nevirapine is, in general, only prescribed after the immune system has declined and infections have become evident. It is always taken with at least one other HIV medication such as Retrovir or Videx. The virus can develop resistance to nevirapine if the drug is taken alone, although even if used properly, nevirapine is effective for only a limited time.
Mechanism of actionNevirapine binds directly to reverse transcriptase (RT) and blocks the RNA-dependent and DNA-dependent DNA polymerase activities by causing a disruption of the enzyme's catalytic site. The activity of nevirapine does not compete with template or nucleoside triphosphates.
Related Articles
AbsorptionNevirapine is readily absorbed (greater than 90%) after oral administration in healthy subjects and adults with HIV-1 infection. The absolute bioavailability in healthy adults following a single dose administration is 93 ± 9% (mean ± SD) for a 50 mg tablet and 91 ± 8% for an oral solution. Peak plasma nevirapine concentrations of 2 ± 0.4 mcg/mL (7.5 micromolar) were attained by 4 hours following a single 200 mg dose. Nevirapine tablets and suspension have been shown to be comparably bioavailable and interchangeable at doses up to 200 mg. When the oral tablet is given with a high-fat meal, the extent of absorption is compared to that of the fasted-state.
Volume of distribution
  • 1.21 ± 0.09 L/kg [apparent volume of distribution, healthy adults, IV]
    Nevirapine is capable of crossing the placenta and is found in breast milk.
Protein binding60% bound to plasma protein.
Metabolism

Hepatic. In vivo studies in humans and in vitro studies with human liver microsomes have shown that nevirapine is extensively biotransformed via cytochrome P450 3A4 metabolism to several hydroxylated metabolites.

SubstrateEnzymesProduct
Nevirapine
12-HydroxynevirapineDetails
Nevirapine
2-HydroxynevirapineDetails
Nevirapine
8-HydroxynevirapineDetails
Nevirapine
3-HydroxynevirapineDetails
12-Hydroxynevirapine
Not Available
12-hydroxynevirapine glucuronideDetails
12-Hydroxynevirapine
4-carboxynevirapineDetails
2-Hydroxynevirapine
Not Available
2-hydroxynevirapine glucuronideDetails
8-Hydroxynevirapine
Not Available
8-hydroxynevirapine glucuronideDetails
3-Hydroxynevirapine
Not Available
3-hydroxynevirapine glucuronideDetails
Route of eliminationThus cytochrome P450 metabolism, glucuronide conjugation, and urinary excretion of glucuronidated metabolites represent the primary route of nevirapine biotransformation and elimination in humans. Only a small fraction (<5%) of the radioactivity in urine (representing <3% of the total dose) was made up of parent compound; therefore, renal excretion plays a minor role in elimination of the parent compound.
Half life45 hours
ClearanceNot Available
ToxicitySymptoms of overdose include edema, erythema nodosum, fatigue, fever, headache, insomnia, nausea, pulmonaryinfiltrates, rash, vertigo, vomiting, and weight decrease. The most common adverse reaction is rash.
Affected organisms
  • Human Immunodeficiency Virus
Pathways
PathwayCategorySMPDB ID
Nevirapine Action PathwayDrug actionSMP00743
Nevirapine Metabolism PathwayDrug metabolismSMP00642
SNP Mediated EffectsNot Available
SNP Mediated Adverse Drug ReactionsNot Available
ADMET
Predicted ADMET features
PropertyValueProbability
Human Intestinal Absorption+0.9958
Blood Brain Barrier+0.9756
Caco-2 permeable+0.8867
P-glycoprotein substrateNon-substrate0.5606
P-glycoprotein inhibitor INon-inhibitor0.6488
P-glycoprotein inhibitor IINon-inhibitor0.8514
Renal organic cation transporterNon-inhibitor0.7124
CYP450 2C9 substrateNon-substrate0.6179
CYP450 2D6 substrateSubstrate0.8919
CYP450 3A4 substrateSubstrate0.6413
CYP450 1A2 substrateInhibitor0.6175
CYP450 2C9 inhibitorNon-inhibitor0.8009
CYP450 2D6 inhibitorNon-inhibitor0.9451
CYP450 2C19 inhibitorNon-inhibitor0.7971
CYP450 3A4 inhibitorNon-inhibitor0.8309
CYP450 inhibitory promiscuityLow CYP Inhibitory Promiscuity0.5443
Ames testAMES toxic0.5952
CarcinogenicityNon-carcinogens0.9383
BiodegradationNot ready biodegradable0.964
Rat acute toxicity2.6729 LD50, mol/kg Not applicable
hERG inhibition (predictor I)Weak inhibitor0.9827
hERG inhibition (predictor II)Non-inhibitor0.8321
ADMET data is predicted using admetSAR, a free tool for evaluating chemical ADMET properties. (23092397 )
Pharmacoeconomics
Manufacturers
  • Boehringer ingelheim pharmaceuticals inc
Packagers
Dosage forms
FormRouteStrength
Tabletoral
Suspensionoral50 mg/5mL
Tabletoral200 mg/1
Tablet, coatedoral200 mg/1
Tablet, extended releaseoral100 mg/1
Tablet, extended releaseoral400 mg/1
Tabletoral400 mg/1
Tabletoral200 mg
Tablet (extended-release)oral400 mg
Prices
Unit descriptionCostUnit
Viramune 200 mg tablet9.3USD tablet
DrugBank does not sell nor buy drugs. Pricing information is supplied for informational purposes only.
Patents
Patent NumberPediatric ExtensionApprovedExpires (estimated)
CA2030056 No1995-10-172010-11-15Canada
US5366972 No1995-05-222012-05-22Us
US8460704 No2009-03-122029-03-12Us
Properties
StateSolid
Experimental Properties
PropertyValueSource
melting point196.06Not Available
water solubility0.7046 mg/LNot Available
logP2.5Not Available
Caco2 permeability-4.52ADME Research, USCD
Predicted Properties
PropertyValueSource
Water Solubility0.105 mg/mLALOGPS
logP1.75ALOGPS
logP2.49ChemAxon
logS-3.4ALOGPS
pKa (Strongest Acidic)10.37ChemAxon
pKa (Strongest Basic)5.06ChemAxon
Physiological Charge0ChemAxon
Hydrogen Acceptor Count4ChemAxon
Hydrogen Donor Count1ChemAxon
Polar Surface Area58.12 Å2ChemAxon
Rotatable Bond Count1ChemAxon
Refractivity77.48 m3·mol-1ChemAxon
Polarizability27.8 Å3ChemAxon
Number of Rings4ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleYesChemAxon
Spectra
Mass Spec (NIST)Not Available
Spectra
Spectrum TypeDescriptionSplash Key
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, PositiveNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, PositiveNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, PositiveNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, NegativeNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, NegativeNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, NegativeNot Available
References
Synthesis Reference

DrugSyn.org

US5366972
General ReferencesNot Available
External Links
ATC CodesJ05AG01J05AR05J05AR07
AHFS Codes
  • 08:18.08.16
PDB EntriesNot Available
FDA labelDownload (423 KB)
MSDSDownload (57 KB)
Interactions
Drug Interactions
Drug
4-AndrostenedioneThe serum concentration of 4-Androstenedione can be decreased when it is combined with Nevirapine.
4-MethoxyamphetamineThe metabolism of 4-Methoxyamphetamine can be decreased when combined with Nevirapine.
AbirateroneThe serum concentration of Abiraterone can be decreased when it is combined with Nevirapine.
AbirateroneThe metabolism of Nevirapine can be decreased when combined with Abiraterone.
AcenocoumarolThe metabolism of Acenocoumarol can be decreased when combined with Nevirapine.
AcetaminophenThe metabolism of Acetaminophen can be decreased when combined with Nevirapine.
AcetylcholineThe metabolism of Acetylcholine can be decreased when combined with Nevirapine.
AdinazolamThe metabolism of Adinazolam can be decreased when combined with Nevirapine.
AgomelatineThe serum concentration of Agomelatine can be increased when it is combined with Nevirapine.
AjmalineThe metabolism of Ajmaline can be decreased when combined with Nevirapine.
AlbendazoleThe metabolism of Albendazole can be decreased when combined with Nevirapine.
AlclometasoneThe metabolism of Alclometasone can be decreased when combined with Nevirapine.
AldosteroneThe serum concentration of Aldosterone can be decreased when it is combined with Nevirapine.
AlfentanilThe metabolism of Alfentanil can be decreased when combined with Nevirapine.
AlfuzosinThe metabolism of Alfuzosin can be decreased when combined with Nevirapine.
AliskirenThe metabolism of Aliskiren can be decreased when combined with Nevirapine.
AllylestrenolThe metabolism of Allylestrenol can be decreased when combined with Nevirapine.
AlmotriptanThe metabolism of Almotriptan can be decreased when combined with Nevirapine.
AlogliptinThe metabolism of Alogliptin can be decreased when combined with Nevirapine.
AlosetronThe metabolism of Alosetron can be decreased when combined with Nevirapine.
AlprazolamThe metabolism of Alprazolam can be decreased when combined with Nevirapine.
AlprenololThe metabolism of Alprenolol can be decreased when combined with Nevirapine.
AmbrisentanThe metabolism of Ambrisentan can be decreased when combined with Nevirapine.
AmbroxolThe metabolism of Ambroxol can be decreased when combined with Nevirapine.
AmcinonideThe serum concentration of Amcinonide can be decreased when it is combined with Nevirapine.
AminophenazoneThe metabolism of Aminophenazone can be decreased when combined with Nevirapine.
AminophyllineThe metabolism of Aminophylline can be decreased when combined with Nevirapine.
AmiodaroneThe metabolism of Amiodarone can be decreased when combined with Nevirapine.
AmitriptylineThe metabolism of Amitriptyline can be decreased when combined with Nevirapine.
AmlodipineThe metabolism of Amlodipine can be decreased when combined with Nevirapine.
AmoxapineThe metabolism of Amoxapine can be decreased when combined with Nevirapine.
AmphetamineThe metabolism of Amphetamine can be decreased when combined with Nevirapine.
AmprenavirThe metabolism of Amprenavir can be decreased when combined with Nevirapine.
AmsacrineThe metabolism of Amsacrine can be decreased when combined with Nevirapine.
AnagrelideThe metabolism of Anagrelide can be decreased when combined with Nevirapine.
AntipyrineThe metabolism of Antipyrine can be decreased when combined with Nevirapine.
ApixabanThe serum concentration of Apixaban can be decreased when it is combined with Nevirapine.
ApremilastThe serum concentration of Apremilast can be decreased when it is combined with Nevirapine.
AprepitantThe serum concentration of Nevirapine can be increased when it is combined with Aprepitant.
AprepitantThe metabolism of Aprepitant can be decreased when combined with Nevirapine.
AprindineThe metabolism of Aprindine can be decreased when combined with Nevirapine.
ArformoterolThe metabolism of Arformoterol can be decreased when combined with Nevirapine.
ArgatrobanThe metabolism of Argatroban can be decreased when combined with Nevirapine.
AripiprazoleThe serum concentration of Aripiprazole can be increased when it is combined with Nevirapine.
ArtemetherThe serum concentration of Artemether can be decreased when it is combined with Nevirapine.
ArtemetherThe metabolism of Nevirapine can be decreased when combined with Artemether.
ArtesunateThe serum concentration of the active metabolites of Artesunate can be reduced when Artesunate is used in combination with Nevirapine resulting in a loss in efficacy.
ASA404The metabolism of ASA404 can be decreased when combined with Nevirapine.
AsenapineThe metabolism of Asenapine can be decreased when combined with Nevirapine.
AstemizoleThe metabolism of Astemizole can be decreased when combined with Nevirapine.
AtazanavirThe serum concentration of Nevirapine can be increased when it is combined with Atazanavir.
AtazanavirThe metabolism of Atazanavir can be decreased when combined with Nevirapine.
AtomoxetineThe metabolism of Nevirapine can be decreased when combined with Atomoxetine.
AtorvastatinThe metabolism of Atorvastatin can be decreased when combined with Nevirapine.
AV650The metabolism of AV650 can be decreased when combined with Nevirapine.
AvanafilThe metabolism of Avanafil can be decreased when combined with Nevirapine.
AxitinibThe serum concentration of Axitinib can be decreased when it is combined with Nevirapine.
AzelastineThe metabolism of Azelastine can be decreased when combined with Nevirapine.
AzithromycinThe metabolism of Azithromycin can be decreased when combined with Nevirapine.
BanoxantroneThe metabolism of Banoxantrone can be decreased when combined with Nevirapine.
Beclomethasone dipropionateThe serum concentration of Beclomethasone dipropionate can be decreased when it is combined with Nevirapine.
BedaquilineThe serum concentration of Bedaquiline can be decreased when it is combined with Nevirapine.
BendamustineThe metabolism of Bendamustine can be decreased when combined with Nevirapine.
BenzatropineThe metabolism of Benzatropine can be decreased when combined with Nevirapine.
BenzphetamineThe metabolism of Benzphetamine can be decreased when combined with Nevirapine.
Benzyl alcoholThe metabolism of Benzyl alcohol can be decreased when combined with Nevirapine.
BepridilThe metabolism of Bepridil can be decreased when combined with Nevirapine.
BetamethasoneThe serum concentration of Betamethasone can be decreased when it is combined with Nevirapine.
BetaxololThe metabolism of Betaxolol can be decreased when combined with Nevirapine.
BexaroteneThe serum concentration of Nevirapine can be decreased when it is combined with Bexarotene.
BexaroteneThe metabolism of Bexarotene can be decreased when combined with Nevirapine.
BezafibrateThe metabolism of Bezafibrate can be decreased when combined with Nevirapine.
BicalutamideThe metabolism of Bicalutamide can be decreased when combined with Nevirapine.
BisoprololThe metabolism of Bisoprolol can be decreased when combined with Nevirapine.
BoceprevirThe serum concentration of Boceprevir can be decreased when it is combined with Nevirapine.
BoceprevirThe metabolism of Nevirapine can be decreased when combined with Boceprevir.
BortezomibThe serum concentration of Bortezomib can be decreased when it is combined with Nevirapine.
BortezomibThe metabolism of Nevirapine can be decreased when combined with Bortezomib.
BosentanThe serum concentration of Nevirapine can be decreased when it is combined with Bosentan.
BosentanThe serum concentration of Bosentan can be increased when it is combined with Nevirapine.
BosutinibThe serum concentration of Bosutinib can be increased when it is combined with Nevirapine.
Brentuximab vedotinThe serum concentration of Brentuximab vedotin can be decreased when it is combined with Nevirapine.
BrexpiprazoleThe serum concentration of Brexpiprazole can be increased when it is combined with Nevirapine.
BrinzolamideThe metabolism of Brinzolamide can be decreased when combined with Nevirapine.
BromazepamThe metabolism of Bromazepam can be decreased when combined with Nevirapine.
BromocriptineThe metabolism of Bromocriptine can be decreased when combined with Nevirapine.
BrompheniramineThe metabolism of Brompheniramine can be decreased when combined with Nevirapine.
BudesonideThe metabolism of Budesonide can be decreased when combined with Nevirapine.
BufuralolThe metabolism of Bufuralol can be decreased when combined with Nevirapine.
BupivacaineThe metabolism of Bupivacaine can be decreased when combined with Nevirapine.
BuprenorphineThe metabolism of Buprenorphine can be decreased when combined with Nevirapine.
BupropionThe metabolism of Bupropion can be decreased when combined with Nevirapine.
BuspironeThe metabolism of Buspirone can be decreased when combined with Nevirapine.
BusulfanThe metabolism of Busulfan can be decreased when combined with Nevirapine.
CabazitaxelThe metabolism of Cabazitaxel can be decreased when combined with Nevirapine.
CabergolineThe metabolism of Cabergoline can be decreased when combined with Nevirapine.
CabozantinibThe serum concentration of Cabozantinib can be decreased when it is combined with Nevirapine.
CaffeineThe metabolism of Caffeine can be decreased when combined with Nevirapine.
CalcitriolThe metabolism of Calcitriol can be decreased when combined with Nevirapine.
CanagliflozinThe metabolism of Canagliflozin can be decreased when combined with Nevirapine.
CannabidiolThe serum concentration of Cannabidiol can be decreased when it is combined with Nevirapine.
CapecitabineThe metabolism of Nevirapine can be decreased when combined with Capecitabine.
CaptoprilThe metabolism of Captopril can be decreased when combined with Nevirapine.
CarbamazepineThe metabolism of Nevirapine can be increased when combined with Carbamazepine.
CarbinoxamineThe metabolism of Carbinoxamine can be decreased when combined with Nevirapine.
CariprazineThe metabolism of Cariprazine can be decreased when combined with Nevirapine.
CarmustineThe metabolism of Carmustine can be decreased when combined with Nevirapine.
CarteololThe metabolism of Carteolol can be decreased when combined with Nevirapine.
CarvedilolThe metabolism of Carvedilol can be decreased when combined with Nevirapine.
CaspofunginThe serum concentration of Caspofungin can be decreased when it is combined with Nevirapine.
CelecoxibThe metabolism of Celecoxib can be decreased when combined with Nevirapine.
CeliprololThe metabolism of Celiprolol can be decreased when combined with Nevirapine.
CephalexinThe metabolism of Cephalexin can be decreased when combined with Nevirapine.
CeritinibThe serum concentration of Nevirapine can be increased when it is combined with Ceritinib.
CeritinibThe serum concentration of Ceritinib can be decreased when it is combined with Nevirapine.
CerivastatinThe metabolism of Cerivastatin can be decreased when combined with Nevirapine.
CevimelineThe metabolism of Cevimeline can be decreased when combined with Nevirapine.
Chenodeoxycholic acidThe metabolism of Chenodeoxycholic acid can be decreased when combined with Nevirapine.
ChlordiazepoxideThe metabolism of Chlordiazepoxide can be decreased when combined with Nevirapine.
ChloroquineThe metabolism of Chloroquine can be decreased when combined with Nevirapine.
ChlorphenamineThe metabolism of Chlorphenamine can be decreased when combined with Nevirapine.
ChlorpromazineThe metabolism of Chlorpromazine can be decreased when combined with Nevirapine.
ChlorzoxazoneThe metabolism of Chlorzoxazone can be decreased when combined with Nevirapine.
CholecalciferolThe metabolism of Cholecalciferol can be decreased when combined with Nevirapine.
CiclesonideThe metabolism of Ciclesonide can be decreased when combined with Nevirapine.
CilostazolThe metabolism of Cilostazol can be decreased when combined with Nevirapine.
CimetidineThe metabolism of Nevirapine can be decreased when combined with Cimetidine.
CinacalcetThe metabolism of Cinacalcet can be decreased when combined with Nevirapine.
CinnarizineThe metabolism of Cinnarizine can be decreased when combined with Nevirapine.
CisaprideThe metabolism of Cisapride can be decreased when combined with Nevirapine.
CitalopramThe metabolism of Citalopram can be decreased when combined with Nevirapine.
ClarithromycinThe metabolism of Clarithromycin can be decreased when combined with Nevirapine.
ClemastineThe metabolism of Nevirapine can be decreased when combined with Clemastine.
ClenbuterolThe metabolism of Clenbuterol can be decreased when combined with Nevirapine.
ClevidipineThe metabolism of Clevidipine can be decreased when combined with Nevirapine.
ClindamycinThe metabolism of Clindamycin can be decreased when combined with Nevirapine.
ClobazamThe metabolism of Clobazam can be decreased when combined with Nevirapine.
Clobetasol propionateThe serum concentration of Clobetasol propionate can be decreased when it is combined with Nevirapine.
ClocortoloneThe serum concentration of Clocortolone can be decreased when it is combined with Nevirapine.
ClofazimineThe metabolism of Clofazimine can be decreased when combined with Nevirapine.
ClofibrateThe metabolism of Clofibrate can be decreased when combined with Nevirapine.
clomethiazoleThe metabolism of clomethiazole can be decreased when combined with Nevirapine.
ClomipramineThe metabolism of Clomipramine can be decreased when combined with Nevirapine.
ClonazepamThe metabolism of Clonazepam can be decreased when combined with Nevirapine.
ClonidineThe metabolism of Clonidine can be decreased when combined with Nevirapine.
ClopidogrelThe metabolism of Clopidogrel can be decreased when combined with Nevirapine.
ClorazepateThe metabolism of Clorazepate can be decreased when combined with Nevirapine.
ClotiazepamThe metabolism of Clotiazepam can be decreased when combined with Nevirapine.
ClotrimazoleThe metabolism of Nevirapine can be decreased when combined with Clotrimazole.
ClozapineThe serum concentration of Clozapine can be decreased when it is combined with Nevirapine.
ClozapineThe metabolism of Nevirapine can be decreased when combined with Clozapine.
CobicistatThe serum concentration of Nevirapine can be increased when it is combined with Cobicistat.
CobimetinibThe serum concentration of Cobimetinib can be decreased when it is combined with Nevirapine.
CocaineThe metabolism of Cocaine can be decreased when combined with Nevirapine.
CodeineThe therapeutic efficacy of Codeine can be decreased when used in combination with Nevirapine.
ColchicineThe metabolism of Colchicine can be decreased when combined with Nevirapine.
ConivaptanThe serum concentration of Nevirapine can be increased when it is combined with Conivaptan.
ConivaptanThe metabolism of Conivaptan can be decreased when combined with Nevirapine.
Conjugated Equine EstrogensThe metabolism of Conjugated Equine Estrogens can be decreased when combined with Nevirapine.
Cortisone acetateThe metabolism of Cortisone acetate can be decreased when combined with Nevirapine.
CrizotinibThe serum concentration of Crizotinib can be decreased when it is combined with Nevirapine.
CrizotinibThe metabolism of Nevirapine can be decreased when combined with Crizotinib.
CyclobenzaprineThe metabolism of Cyclobenzaprine can be decreased when combined with Nevirapine.
CyclophosphamideThe metabolism of Cyclophosphamide can be decreased when combined with Nevirapine.
CyclosporineThe metabolism of Cyclosporine can be decreased when combined with Nevirapine.
CytarabineThe metabolism of Cytarabine can be decreased when combined with Nevirapine.
DabrafenibThe serum concentration of Nevirapine can be decreased when it is combined with Dabrafenib.
DabrafenibThe metabolism of Dabrafenib can be decreased when combined with Nevirapine.
DacarbazineThe metabolism of Dacarbazine can be decreased when combined with Nevirapine.
DaclatasvirThe serum concentration of Daclatasvir can be decreased when it is combined with Nevirapine.
DantroleneThe metabolism of Dantrolene can be decreased when combined with Nevirapine.
DapagliflozinThe metabolism of Dapagliflozin can be decreased when combined with Nevirapine.
DapoxetineThe serum concentration of Dapoxetine can be increased when it is combined with Nevirapine.
DapsoneThe metabolism of Dapsone can be decreased when combined with Nevirapine.
DarifenacinThe metabolism of Darifenacin can be decreased when combined with Nevirapine.
DarunavirThe serum concentration of Nevirapine can be increased when it is combined with Darunavir.
DarunavirThe metabolism of Darunavir can be decreased when combined with Nevirapine.
DasabuvirThe metabolism of Dasabuvir can be decreased when combined with Nevirapine.
DasatinibThe serum concentration of Nevirapine can be increased when it is combined with Dasatinib.
DasatinibThe metabolism of Dasatinib can be decreased when combined with Nevirapine.
DaunorubicinThe metabolism of Daunorubicin can be decreased when combined with Nevirapine.
DebrisoquinThe metabolism of Debrisoquin can be decreased when combined with Nevirapine.
DeferasiroxThe serum concentration of Nevirapine can be decreased when it is combined with Deferasirox.
DehydroepiandrosteroneThe metabolism of Dehydroepiandrosterone can be decreased when combined with Nevirapine.
dehydroepiandrosterone sulfateThe serum concentration of dehydroepiandrosterone sulfate can be decreased when it is combined with Nevirapine.
DelavirdineThe metabolism of Delavirdine can be decreased when combined with Nevirapine.
DesipramineThe metabolism of Desipramine can be decreased when combined with Nevirapine.
DesoximetasoneThe serum concentration of Desoximetasone can be decreased when it is combined with Nevirapine.
Desoxycorticosterone acetateThe serum concentration of Desoxycorticosterone acetate can be decreased when it is combined with Nevirapine.
DesvenlafaxineThe metabolism of Desvenlafaxine can be decreased when combined with Nevirapine.
DexamethasoneThe serum concentration of Nevirapine can be decreased when it is combined with Dexamethasone.
DexamethasoneThe metabolism of Dexamethasone can be decreased when combined with Nevirapine.
Dexamethasone isonicotinateThe serum concentration of Dexamethasone isonicotinate can be decreased when it is combined with Nevirapine.
DexfenfluramineThe metabolism of Dexfenfluramine can be decreased when combined with Nevirapine.
DexmethylphenidateThe metabolism of Dexmethylphenidate can be decreased when combined with Nevirapine.
DextroamphetamineThe metabolism of Dextroamphetamine can be decreased when combined with Nevirapine.
DextromethorphanThe metabolism of Dextromethorphan can be decreased when combined with Nevirapine.
DextropropoxypheneThe metabolism of Dextropropoxyphene can be decreased when combined with Nevirapine.
DiazepamThe metabolism of Diazepam can be decreased when combined with Nevirapine.
DiclofenacThe metabolism of Diclofenac can be decreased when combined with Nevirapine.
DienogestThe serum concentration of Dienogest can be decreased when it is combined with Nevirapine.
DiflorasoneThe serum concentration of Diflorasone can be decreased when it is combined with Nevirapine.
DifluocortoloneThe serum concentration of Difluocortolone can be decreased when it is combined with Nevirapine.
DifluprednateThe serum concentration of Difluprednate can be decreased when it is combined with Nevirapine.
DigitoxinThe metabolism of Digitoxin can be decreased when combined with Nevirapine.
DigoxinThe metabolism of Digoxin can be decreased when combined with Nevirapine.
DihydrocodeineThe metabolism of Dihydrocodeine can be decreased when combined with Nevirapine.
DihydroergotamineThe metabolism of Dihydroergotamine can be decreased when combined with Nevirapine.
DiltiazemThe metabolism of Diltiazem can be decreased when combined with Nevirapine.
DinoprostoneThe metabolism of Dinoprostone can be decreased when combined with Nevirapine.
DiphenhydramineThe metabolism of Diphenhydramine can be decreased when combined with Nevirapine.
DisopyramideThe metabolism of Disopyramide can be decreased when combined with Nevirapine.
DisulfiramThe metabolism of Disulfiram can be decreased when combined with Nevirapine.
DocetaxelThe metabolism of Docetaxel can be decreased when combined with Nevirapine.
DofetilideThe serum concentration of Dofetilide can be increased when it is combined with Nevirapine.
DolasetronThe metabolism of Dolasetron can be decreased when combined with Nevirapine.
DolutegravirThe serum concentration of Dolutegravir can be decreased when it is combined with Nevirapine.
DomperidoneThe serum concentration of Domperidone can be increased when it is combined with Nevirapine.
DonepezilThe metabolism of Donepezil can be decreased when combined with Nevirapine.
DopamineThe metabolism of Dopamine can be decreased when combined with Nevirapine.
DorzolamideThe metabolism of Dorzolamide can be decreased when combined with Nevirapine.
DoxazosinThe metabolism of Doxazosin can be decreased when combined with Nevirapine.
DoxepinThe metabolism of Doxepin can be decreased when combined with Nevirapine.
DoxorubicinThe metabolism of Doxorubicin can be decreased when combined with Nevirapine.
DoxycyclineThe metabolism of Nevirapine can be decreased when combined with Doxycycline.
DronabinolThe serum concentration of Dronabinol can be increased when it is combined with Nevirapine.
DronedaroneThe serum concentration of Dronedarone can be decreased when it is combined with Nevirapine.
DronedaroneThe metabolism of Nevirapine can be decreased when combined with Dronedarone.
DuloxetineThe metabolism of Duloxetine can be decreased when combined with Nevirapine.
DutasterideThe metabolism of Dutasteride can be decreased when combined with Nevirapine.
EfavirenzThe risk or severity of adverse effects can be increased when Efavirenz is combined with Nevirapine.
EfavirenzThe metabolism of Efavirenz can be decreased when combined with Nevirapine.
EletriptanThe metabolism of Eletriptan can be decreased when combined with Nevirapine.
EliglustatThe serum concentration of Eliglustat can be decreased when it is combined with Nevirapine.
EliglustatThe metabolism of Nevirapine can be decreased when combined with Eliglustat.
EltrombopagThe metabolism of Eltrombopag can be decreased when combined with Nevirapine.
ElvitegravirThe serum concentration of Elvitegravir can be decreased when it is combined with Nevirapine.
EnalaprilThe metabolism of Enalapril can be decreased when combined with Nevirapine.
EncainideThe metabolism of Encainide can be decreased when combined with Nevirapine.
EnclomipheneThe metabolism of Enclomiphene can be decreased when combined with Nevirapine.
EnzalutamideThe serum concentration of Enzalutamide can be decreased when it is combined with Nevirapine.
EpinastineThe metabolism of Epinastine can be decreased when combined with Nevirapine.
EplerenoneThe metabolism of Eplerenone can be decreased when combined with Nevirapine.
EquileninThe serum concentration of Equilenin can be decreased when it is combined with Nevirapine.
EquilinThe serum concentration of Equilin can be decreased when it is combined with Nevirapine.
ErgocalciferolThe metabolism of Ergocalciferol can be decreased when combined with Nevirapine.
Ergoloid mesylateThe metabolism of Ergoloid mesylate can be decreased when combined with Nevirapine.
ErgonovineThe metabolism of Ergonovine can be decreased when combined with Nevirapine.
ErgotamineThe metabolism of Ergotamine can be decreased when combined with Nevirapine.
ErlotinibThe metabolism of Erlotinib can be decreased when combined with Nevirapine.
ErythromycinThe metabolism of Erythromycin can be decreased when combined with Nevirapine.
EscitalopramThe metabolism of Escitalopram can be decreased when combined with Nevirapine.
Eslicarbazepine acetateThe serum concentration of Nevirapine can be decreased when it is combined with Eslicarbazepine acetate.
EsmirtazapineThe metabolism of Esmirtazapine can be decreased when combined with Nevirapine.
EsomeprazoleThe metabolism of Esomeprazole can be decreased when combined with Nevirapine.
EstazolamThe metabolism of Estazolam can be decreased when combined with Nevirapine.
EstradiolThe metabolism of Estradiol can be decreased when combined with Nevirapine.
Estradiol valerate/DienogestThe metabolism of Estradiol valerate/Dienogest can be decreased when combined with Nevirapine.
EstramustineThe metabolism of Estramustine can be decreased when combined with Nevirapine.
EstroneThe metabolism of Estrone can be decreased when combined with Nevirapine.
Estrone sulfateThe metabolism of Estrone sulfate can be decreased when combined with Nevirapine.
EszopicloneThe metabolism of Eszopiclone can be decreased when combined with Nevirapine.
EthanolThe metabolism of Ethanol can be decreased when combined with Nevirapine.
Ethinyl EstradiolThe metabolism of Ethinyl Estradiol can be decreased when combined with Nevirapine.
EthosuximideThe metabolism of Ethosuximide can be decreased when combined with Nevirapine.
EthylmorphineThe metabolism of Ethylmorphine can be decreased when combined with Nevirapine.
EtonogestrelThe metabolism of Etonogestrel can be decreased when combined with Nevirapine.
EtoposideThe metabolism of Etoposide can be decreased when combined with Nevirapine.
EtoricoxibThe metabolism of Etoricoxib can be decreased when combined with Nevirapine.
EtravirineThe serum concentration of Nevirapine can be decreased when it is combined with Etravirine.
EtravirineThe metabolism of Etravirine can be decreased when combined with Nevirapine.
EverolimusThe serum concentration of Everolimus can be decreased when it is combined with Nevirapine.
ExemestaneThe metabolism of Exemestane can be decreased when combined with Nevirapine.
FamciclovirThe metabolism of Famciclovir can be decreased when combined with Nevirapine.
FelbamateThe metabolism of Felbamate can be decreased when combined with Nevirapine.
FelodipineThe metabolism of Felodipine can be decreased when combined with Nevirapine.
FenofibrateThe metabolism of Fenofibrate can be decreased when combined with Nevirapine.
FentanylThe serum concentration of Fentanyl can be decreased when it is combined with Nevirapine.
FesoterodineThe serum concentration of the active metabolites of Fesoterodine can be increased when Fesoterodine is used in combination with Nevirapine.
FinasterideThe metabolism of Finasteride can be decreased when combined with Nevirapine.
FingolimodThe metabolism of Fingolimod can be decreased when combined with Nevirapine.
FlecainideThe metabolism of Flecainide can be decreased when combined with Nevirapine.
FlibanserinThe serum concentration of Flibanserin can be increased when it is combined with Nevirapine.
FloxuridineThe metabolism of Nevirapine can be decreased when combined with Floxuridine.
FluconazoleThe serum concentration of Nevirapine can be increased when it is combined with Fluconazole.
FludrocortisoneThe serum concentration of Fludrocortisone can be decreased when it is combined with Nevirapine.
FlumethasoneThe serum concentration of Flumethasone can be decreased when it is combined with Nevirapine.
FlunarizineThe metabolism of Flunarizine can be decreased when combined with Nevirapine.
FlunisolideThe metabolism of Flunisolide can be decreased when combined with Nevirapine.
FlunitrazepamThe metabolism of Flunitrazepam can be decreased when combined with Nevirapine.
Fluocinolone AcetonideThe serum concentration of Fluocinolone Acetonide can be decreased when it is combined with Nevirapine.
FluocinonideThe serum concentration of Fluocinonide can be decreased when it is combined with Nevirapine.
FluocortoloneThe serum concentration of Fluocortolone can be decreased when it is combined with Nevirapine.
FluorometholoneThe metabolism of Fluorometholone can be decreased when combined with Nevirapine.
FluorouracilThe metabolism of Fluorouracil can be decreased when combined with Nevirapine.
FluoxetineThe metabolism of Fluoxetine can be decreased when combined with Nevirapine.
FluphenazineThe metabolism of Fluphenazine can be decreased when combined with Nevirapine.
FluprednideneThe serum concentration of Fluprednidene can be decreased when it is combined with Nevirapine.
FluprednisoloneThe serum concentration of Fluprednisolone can be decreased when it is combined with Nevirapine.
FlurandrenolideThe serum concentration of Flurandrenolide can be decreased when it is combined with Nevirapine.
FlurazepamThe metabolism of Flurazepam can be decreased when combined with Nevirapine.
FlutamideThe metabolism of Flutamide can be decreased when combined with Nevirapine.
Fluticasone furoateThe metabolism of Fluticasone furoate can be decreased when combined with Nevirapine.
Fluticasone PropionateThe metabolism of Fluticasone Propionate can be decreased when combined with Nevirapine.
FluvastatinThe metabolism of Fluvastatin can be decreased when combined with Nevirapine.
FluvoxamineThe metabolism of Nevirapine can be decreased when combined with Fluvoxamine.
FormoterolThe metabolism of Formoterol can be decreased when combined with Nevirapine.
FosamprenavirThe metabolism of Fosamprenavir can be decreased when combined with Nevirapine.
FosaprepitantThe serum concentration of Nevirapine can be increased when it is combined with Fosaprepitant.
FosphenytoinThe metabolism of Nevirapine can be increased when combined with Fosphenytoin.
FrovatriptanThe metabolism of Frovatriptan can be decreased when combined with Nevirapine.
FulvestrantThe metabolism of Fulvestrant can be decreased when combined with Nevirapine.
Fusidic AcidThe serum concentration of Nevirapine can be increased when it is combined with Fusidic Acid.
GalantamineThe metabolism of Galantamine can be decreased when combined with Nevirapine.
GefitinibThe metabolism of Gefitinib can be decreased when combined with Nevirapine.
GemfibrozilThe metabolism of Gemfibrozil can be decreased when combined with Nevirapine.
GenisteinThe metabolism of Genistein can be decreased when combined with Nevirapine.
GlipizideThe metabolism of Glipizide can be decreased when combined with Nevirapine.
GlyburideThe metabolism of Glyburide can be decreased when combined with Nevirapine.
GranisetronThe metabolism of Granisetron can be decreased when combined with Nevirapine.
GrepafloxacinThe metabolism of Grepafloxacin can be decreased when combined with Nevirapine.
GuanabenzThe metabolism of Guanabenz can be decreased when combined with Nevirapine.
GuanfacineThe metabolism of Guanfacine can be decreased when combined with Nevirapine.
HalofantrineThe metabolism of Halofantrine can be decreased when combined with Nevirapine.
HaloperidolThe metabolism of Haloperidol can be decreased when combined with Nevirapine.
HalothaneThe metabolism of Halothane can be decreased when combined with Nevirapine.
HesperetinThe metabolism of Hesperetin can be decreased when combined with Nevirapine.
HexobarbitalThe metabolism of Hexobarbital can be decreased when combined with Nevirapine.
Histamine PhosphateThe metabolism of Histamine Phosphate can be decreased when combined with Nevirapine.
HydrocodoneThe serum concentration of Hydrocodone can be decreased when it is combined with Nevirapine.
HydrocortisoneThe serum concentration of Hydrocortisone can be decreased when it is combined with Nevirapine.
HydromorphoneThe metabolism of Hydromorphone can be decreased when combined with Nevirapine.
Hydroxyprogesterone caproateThe metabolism of Hydroxyprogesterone caproate can be decreased when combined with Nevirapine.
IbrutinibThe serum concentration of Ibrutinib can be increased when it is combined with Nevirapine.
IdarubicinThe metabolism of Idarubicin can be decreased when combined with Nevirapine.
IdelalisibThe serum concentration of Nevirapine can be increased when it is combined with Idelalisib.
IdelalisibThe serum concentration of Idelalisib can be decreased when it is combined with Nevirapine.
IfosfamideThe serum concentration of the active metabolites of Ifosfamide can be reduced when Ifosfamide is used in combination with Nevirapine resulting in a loss in efficacy.
IloperidoneThe metabolism of Iloperidone can be decreased when combined with Nevirapine.
ImatinibThe serum concentration of Imatinib can be increased when it is combined with Nevirapine.
ImatinibThe metabolism of Nevirapine can be decreased when combined with Imatinib.
ImipramineThe metabolism of Imipramine can be decreased when combined with Nevirapine.
ImiquimodThe metabolism of Imiquimod can be decreased when combined with Nevirapine.
IndacaterolThe metabolism of Indacaterol can be decreased when combined with Nevirapine.
IndapamideThe metabolism of Indapamide can be decreased when combined with Nevirapine.
IndinavirThe metabolism of Indinavir can be decreased when combined with Nevirapine.
Ipratropium bromideThe metabolism of Ipratropium bromide can be decreased when combined with Nevirapine.
IrbesartanThe metabolism of Nevirapine can be decreased when combined with Irbesartan.
IrinotecanThe serum concentration of the active metabolites of Irinotecan can be reduced when Irinotecan is used in combination with Nevirapine resulting in a loss in efficacy.
IsavuconazoniumThe serum concentration of the active metabolites of Isavuconazonium can be reduced when Isavuconazonium is used in combination with Nevirapine resulting in a loss in efficacy.
IsavuconazoniumThe metabolism of Nevirapine can be decreased when combined with Isavuconazonium.
IsofluraneThe metabolism of Isoflurane can be increased when combined with Nevirapine.
IsoniazidThe metabolism of Nevirapine can be decreased when combined with Isoniazid.
Isosorbide DinitrateThe metabolism of Isosorbide Dinitrate can be decreased when combined with Nevirapine.
Isosorbide MononitrateThe metabolism of Isosorbide Mononitrate can be decreased when combined with Nevirapine.
IsradipineThe metabolism of Isradipine can be decreased when combined with Nevirapine.
ItraconazoleThe serum concentration of Itraconazole can be decreased when it is combined with Nevirapine.
ItraconazoleThe metabolism of Nevirapine can be decreased when combined with Itraconazole.
IvabradineThe serum concentration of Ivabradine can be increased when it is combined with Nevirapine.
IvacaftorThe serum concentration of Nevirapine can be increased when it is combined with Ivacaftor.
IvacaftorThe serum concentration of Ivacaftor can be decreased when it is combined with Nevirapine.
IvermectinThe metabolism of Ivermectin can be decreased when combined with Nevirapine.
IxabepiloneThe metabolism of Ixabepilone can be decreased when combined with Nevirapine.
IxazomibThe serum concentration of Ixazomib can be decreased when it is combined with Nevirapine.
KetamineThe metabolism of Ketamine can be decreased when combined with Nevirapine.
KetazolamThe metabolism of Ketazolam can be decreased when combined with Nevirapine.
KetobemidoneThe metabolism of Ketobemidone can be decreased when combined with Nevirapine.
KetoconazoleThe serum concentration of Ketoconazole can be decreased when it is combined with Nevirapine.
KetoconazoleThe metabolism of Nevirapine can be decreased when combined with Ketoconazole.
LabetalolThe metabolism of Labetalol can be decreased when combined with Nevirapine.
LansoprazoleThe metabolism of Lansoprazole can be decreased when combined with Nevirapine.
LapatinibThe serum concentration of Lapatinib can be decreased when it is combined with Nevirapine.
LaquinimodThe metabolism of Laquinimod can be decreased when combined with Nevirapine.
LeflunomideThe metabolism of Leflunomide can be decreased when combined with Nevirapine.
LenvatinibThe metabolism of Lenvatinib can be decreased when combined with Nevirapine.
LercanidipineThe metabolism of Lercanidipine can be decreased when combined with Nevirapine.
LetrozoleThe metabolism of Letrozole can be decreased when combined with Nevirapine.
LevobupivacaineThe metabolism of Levobupivacaine can be decreased when combined with Nevirapine.
LevocetirizineThe metabolism of Levocetirizine can be decreased when combined with Nevirapine.
LevodopaThe metabolism of Levodopa can be decreased when combined with Nevirapine.
Levomethadyl AcetateThe metabolism of Levomethadyl Acetate can be decreased when combined with Nevirapine.
LevomilnacipranThe metabolism of Levomilnacipran can be decreased when combined with Nevirapine.
LevonorgestrelThe metabolism of Levonorgestrel can be decreased when combined with Nevirapine.
LevothyroxineThe metabolism of Levothyroxine can be decreased when combined with Nevirapine.
LidocaineThe metabolism of Lidocaine can be decreased when combined with Nevirapine.
LinagliptinThe serum concentration of Linagliptin can be decreased when it is combined with Nevirapine.
LisurideThe metabolism of Lisuride can be decreased when combined with Nevirapine.
LomefloxacinThe metabolism of Lomefloxacin can be decreased when combined with Nevirapine.
LomitapideThe serum concentration of Lomitapide can be increased when it is combined with Nevirapine.
LomustineThe metabolism of Lomustine can be decreased when combined with Nevirapine.
LoperamideThe metabolism of Loperamide can be decreased when combined with Nevirapine.
LopinavirThe metabolism of Lopinavir can be decreased when combined with Nevirapine.
LoratadineThe metabolism of Loratadine can be decreased when combined with Nevirapine.
LorcaserinThe metabolism of Lorcaserin can be decreased when combined with Nevirapine.
LosartanThe metabolism of Losartan can be decreased when combined with Nevirapine.
LovastatinThe metabolism of Nevirapine can be decreased when combined with Lovastatin.
LuliconazoleThe serum concentration of Nevirapine can be increased when it is combined with Luliconazole.
LumacaftorThe serum concentration of Nevirapine can be decreased when it is combined with Lumacaftor.
LumefantrineThe serum concentration of Lumefantrine can be decreased when it is combined with Nevirapine.
LumefantrineThe metabolism of Nevirapine can be decreased when combined with Lumefantrine.
LumiracoxibThe metabolism of Lumiracoxib can be decreased when combined with Nevirapine.
LurasidoneThe serum concentration of Lurasidone can be decreased when it is combined with Nevirapine.
MacitentanThe serum concentration of Macitentan can be decreased when it is combined with Nevirapine.
MalathionThe metabolism of Malathion can be decreased when combined with Nevirapine.
MaprotilineThe metabolism of Maprotiline can be decreased when combined with Nevirapine.
MaravirocThe metabolism of Maraviroc can be decreased when combined with Nevirapine.
MebendazoleThe metabolism of Mebendazole can be decreased when combined with Nevirapine.
Medroxyprogesterone acetateThe metabolism of Medroxyprogesterone acetate can be decreased when combined with Nevirapine.
MedrysoneThe serum concentration of Medrysone can be decreased when it is combined with Nevirapine.
MefloquineThe metabolism of Mefloquine can be decreased when combined with Nevirapine.
MelatoninThe metabolism of Melatonin can be decreased when combined with Nevirapine.
MelengestrolThe serum concentration of Melengestrol can be decreased when it is combined with Nevirapine.
MeloxicamThe metabolism of Meloxicam can be decreased when combined with Nevirapine.
MenadioneThe metabolism of Menadione can be decreased when combined with Nevirapine.
MephenytoinThe metabolism of Mephenytoin can be decreased when combined with Nevirapine.
MequitazineThe metabolism of Mequitazine can be decreased when combined with Nevirapine.
MesoridazineThe metabolism of Mesoridazine can be decreased when combined with Nevirapine.
MethadoneThe metabolism of Methadone can be decreased when combined with Nevirapine.
MethamphetamineThe metabolism of Methamphetamine can be decreased when combined with Nevirapine.
MethaqualoneThe metabolism of Methaqualone can be decreased when combined with Nevirapine.
MethotrimeprazineThe metabolism of Methotrimeprazine can be decreased when combined with Nevirapine.
MethoxsalenThe metabolism of Methoxsalen can be decreased when combined with Nevirapine.
MethoxyfluraneThe metabolism of Methoxyflurane can be decreased when combined with Nevirapine.
MethylphenidateThe metabolism of Methylphenidate can be decreased when combined with Nevirapine.
MethylphenobarbitalThe metabolism of Methylphenobarbital can be increased when combined with Nevirapine.
MethylprednisoloneThe metabolism of Methylprednisolone can be decreased when combined with Nevirapine.
MethyltestosteroneThe metabolism of Methyltestosterone can be decreased when combined with Nevirapine.
MethyprylonThe metabolism of Methyprylon can be decreased when combined with Nevirapine.
MetoclopramideThe metabolism of Metoclopramide can be decreased when combined with Nevirapine.
MetoprololThe metabolism of Nevirapine can be decreased when combined with Metoprolol.
MetronidazoleThe metabolism of Metronidazole can be decreased when combined with Nevirapine.
MexiletineThe metabolism of Mexiletine can be decreased when combined with Nevirapine.
MianserinThe metabolism of Mianserin can be decreased when combined with Nevirapine.
MibefradilThe metabolism of Mibefradil can be decreased when combined with Nevirapine.
MiconazoleThe metabolism of Miconazole can be decreased when combined with Nevirapine.
MidazolamThe metabolism of Midazolam can be decreased when combined with Nevirapine.
MifepristoneThe serum concentration of Mifepristone can be decreased when it is combined with Nevirapine.
MifepristoneThe metabolism of Nevirapine can be decreased when combined with Mifepristone.
MinaprineThe metabolism of Minaprine can be decreased when combined with Nevirapine.
MirabegronThe metabolism of Mirabegron can be decreased when combined with Nevirapine.
MirtazapineThe metabolism of Mirtazapine can be decreased when combined with Nevirapine.
MitotaneThe serum concentration of Nevirapine can be decreased when it is combined with Mitotane.
MoclobemideThe metabolism of Moclobemide can be decreased when combined with Nevirapine.
ModafinilThe serum concentration of Nevirapine can be decreased when it is combined with Modafinil.
ModafinilThe metabolism of Modafinil can be decreased when combined with Nevirapine.
MometasoneThe serum concentration of Mometasone can be decreased when it is combined with Nevirapine.
MontelukastThe metabolism of Montelukast can be decreased when combined with Nevirapine.
MorphineThe metabolism of Morphine can be decreased when combined with Nevirapine.
muraglitazarThe metabolism of muraglitazar can be decreased when combined with Nevirapine.
Mycophenolate mofetilThe metabolism of Mycophenolate mofetil can be decreased when combined with Nevirapine.
NabumetoneThe metabolism of Nabumetone can be decreased when combined with Nevirapine.
NafcillinThe serum concentration of Nevirapine can be decreased when it is combined with Nafcillin.
NaloxegolThe serum concentration of Naloxegol can be increased when it is combined with Nevirapine.
NaloxoneThe metabolism of Naloxone can be decreased when combined with Nevirapine.
NaproxenThe metabolism of Naproxen can be decreased when combined with Nevirapine.
NateglinideThe metabolism of Nateglinide can be decreased when combined with Nevirapine.
NebivololThe serum concentration of Nebivolol can be increased when it is combined with Nevirapine.
NefazodoneThe metabolism of Nefazodone can be decreased when combined with Nevirapine.
NelfinavirThe serum concentration of the active metabolites of Nelfinavir can be reduced when Nelfinavir is used in combination with Nevirapine resulting in a loss in efficacy.
NelfinavirThe metabolism of Nevirapine can be decreased when combined with Nelfinavir.
NetupitantThe serum concentration of Nevirapine can be increased when it is combined with Netupitant.
NetupitantThe serum concentration of Netupitant can be decreased when it is combined with Nevirapine.
NicardipineThe metabolism of Nicardipine can be decreased when combined with Nevirapine.
NicergolineThe metabolism of Nicergoline can be decreased when combined with Nevirapine.
NicotineThe metabolism of Nicotine can be decreased when combined with Nevirapine.
NifedipineThe serum concentration of Nifedipine can be decreased when it is combined with Nevirapine.
NilotinibThe serum concentration of Nilotinib can be decreased when it is combined with Nevirapine.
NilotinibThe metabolism of Nevirapine can be decreased when combined with Nilotinib.
NilvadipineThe metabolism of Nilvadipine can be decreased when combined with Nevirapine.
NimodipineThe serum concentration of Nimodipine can be decreased when it is combined with Nevirapine.
NintedanibThe serum concentration of Nintedanib can be decreased when it is combined with Nevirapine.
NisoldipineThe serum concentration of Nisoldipine can be decreased when it is combined with Nevirapine.
NitrazepamThe metabolism of Nitrazepam can be decreased when combined with Nevirapine.
NitrendipineThe metabolism of Nitrendipine can be decreased when combined with Nevirapine.
Nitric OxideThe metabolism of Nitric Oxide can be decreased when combined with Nevirapine.
NitrofuralThe metabolism of Nitrofural can be decreased when combined with Nevirapine.
NorethisteroneThe metabolism of Norethisterone can be decreased when combined with Nevirapine.
NorgestrelThe metabolism of Norgestrel can be decreased when combined with Nevirapine.
NortriptylineThe metabolism of Nortriptyline can be decreased when combined with Nevirapine.
OlanzapineThe metabolism of Olanzapine can be decreased when combined with Nevirapine.
OlaparibThe serum concentration of Olaparib can be increased when it is combined with Nevirapine.
OlaparibThe metabolism of Nevirapine can be decreased when combined with Olaparib.
OlopatadineThe metabolism of Olopatadine can be decreased when combined with Nevirapine.
OmeprazoleThe metabolism of Omeprazole can be decreased when combined with Nevirapine.
OndansetronThe metabolism of Ondansetron can be decreased when combined with Nevirapine.
OrphenadrineThe metabolism of Orphenadrine can be decreased when combined with Nevirapine.
OsimertinibThe serum concentration of Nevirapine can be increased when it is combined with Osimertinib.
OsimertinibThe serum concentration of Osimertinib can be decreased when it is combined with Nevirapine.
OspemifeneThe metabolism of Ospemifene can be decreased when combined with Nevirapine.
OxaliplatinThe metabolism of Oxaliplatin can be decreased when combined with Nevirapine.
OxazepamThe metabolism of Oxazepam can be decreased when combined with Nevirapine.
OxtriphyllineThe metabolism of Oxtriphylline can be decreased when combined with Nevirapine.
OxybutyninThe metabolism of Oxybutynin can be decreased when combined with Nevirapine.
OxycodoneThe metabolism of Oxycodone can be decreased when combined with Nevirapine.
OxymorphoneThe metabolism of Oxymorphone can be decreased when combined with Nevirapine.
PaclitaxelThe metabolism of Paclitaxel can be decreased when combined with Nevirapine.
PalbociclibThe serum concentration of Nevirapine can be increased when it is combined with Palbociclib.
PalbociclibThe serum concentration of Palbociclib can be decreased when it is combined with Nevirapine.
PalonosetronThe metabolism of Palonosetron can be decreased when combined with Nevirapine.
PanobinostatThe serum concentration of Panobinostat can be decreased when it is combined with Nevirapine.
PanobinostatThe metabolism of Nevirapine can be decreased when combined with Panobinostat.
PantoprazoleThe metabolism of Pantoprazole can be decreased when combined with Nevirapine.
ParamethadioneThe metabolism of Paramethadione can be decreased when combined with Nevirapine.
ParamethasoneThe metabolism of Paramethasone can be decreased when combined with Nevirapine.
ParecoxibThe metabolism of Parecoxib can be decreased when combined with Nevirapine.
ParicalcitolThe metabolism of Paricalcitol can be decreased when combined with Nevirapine.
ParitaprevirThe metabolism of Paritaprevir can be decreased when combined with Nevirapine.
ParoxetineThe metabolism of Paroxetine can be decreased when combined with Nevirapine.
PazopanibThe serum concentration of Pazopanib can be decreased when it is combined with Nevirapine.
Peginterferon alfa-2bThe serum concentration of Nevirapine can be decreased when it is combined with Peginterferon alfa-2b.
PentamidineThe metabolism of Pentamidine can be decreased when combined with Nevirapine.
PentobarbitalThe metabolism of Nevirapine can be increased when combined with Pentobarbital.
PentoxifyllineThe metabolism of Pentoxifylline can be decreased when combined with Nevirapine.
PerampanelThe serum concentration of Perampanel can be decreased when it is combined with Nevirapine.
PergolideThe metabolism of Pergolide can be decreased when combined with Nevirapine.
PerhexilineThe metabolism of Perhexiline can be decreased when combined with Nevirapine.
PermethrinThe metabolism of Permethrin can be decreased when combined with Nevirapine.
PerphenazineThe metabolism of Perphenazine can be decreased when combined with Nevirapine.
PethidineThe metabolism of Pethidine can be decreased when combined with Nevirapine.
PhenacetinThe metabolism of Phenacetin can be decreased when combined with Nevirapine.
PhenforminThe metabolism of Phenformin can be decreased when combined with Nevirapine.
PhenobarbitalThe metabolism of Nevirapine can be increased when combined with Phenobarbital.
PhenoxybenzamineThe metabolism of Phenoxybenzamine can be decreased when combined with Nevirapine.
PhenprocoumonThe metabolism of Phenprocoumon can be decreased when combined with Nevirapine.
PhenytoinThe metabolism of Nevirapine can be increased when combined with Phenytoin.
PilocarpineThe metabolism of Pilocarpine can be decreased when combined with Nevirapine.
PimecrolimusThe metabolism of Pimecrolimus can be decreased when combined with Nevirapine.
PimozideThe serum concentration of Pimozide can be increased when it is combined with Nevirapine.
PinacidilThe metabolism of Pinacidil can be decreased when combined with Nevirapine.
PindololThe metabolism of Pindolol can be decreased when combined with Nevirapine.
PioglitazoneThe metabolism of Pioglitazone can be decreased when combined with Nevirapine.
PiperazineThe metabolism of Piperazine can be decreased when combined with Nevirapine.
PipotiazineThe metabolism of Pipotiazine can be decreased when combined with Nevirapine.
PirfenidoneThe serum concentration of Pirfenidone can be increased when it is combined with Nevirapine.
PodofiloxThe metabolism of Podofilox can be decreased when combined with Nevirapine.
PomalidomideThe metabolism of Pomalidomide can be decreased when combined with Nevirapine.
PonatinibThe serum concentration of Ponatinib can be decreased when it is combined with Nevirapine.
PosaconazoleThe metabolism of Posaconazole can be decreased when combined with Nevirapine.
PrasugrelThe metabolism of Prasugrel can be decreased when combined with Nevirapine.
PravastatinThe metabolism of Pravastatin can be decreased when combined with Nevirapine.
PrazepamThe metabolism of Prazepam can be decreased when combined with Nevirapine.
PraziquantelThe serum concentration of Praziquantel can be decreased when it is combined with Nevirapine.
PrednicarbateThe serum concentration of Prednicarbate can be decreased when it is combined with Nevirapine.
PrednisoloneThe serum concentration of Prednisolone can be decreased when it is combined with Nevirapine.
PrednisoneThe serum concentration of Prednisone can be decreased when it is combined with Nevirapine.
PregnenoloneThe serum concentration of Pregnenolone can be decreased when it is combined with Nevirapine.
PrimaquineThe metabolism of Primaquine can be decreased when combined with Nevirapine.
PrimidoneThe metabolism of Nevirapine can be increased when combined with Primidone.
ProcainamideThe metabolism of Procainamide can be decreased when combined with Nevirapine.
ProchlorperazineThe metabolism of Prochlorperazine can be decreased when combined with Nevirapine.
ProgesteroneThe metabolism of Progesterone can be decreased when combined with Nevirapine.
ProguanilThe metabolism of Proguanil can be decreased when combined with Nevirapine.
PromazineThe metabolism of Promazine can be decreased when combined with Nevirapine.
PromethazineThe metabolism of Promethazine can be decreased when combined with Nevirapine.
PropafenoneThe serum concentration of Propafenone can be increased when it is combined with Nevirapine.
PropofolThe metabolism of Propofol can be decreased when combined with Nevirapine.
PropranololThe metabolism of Propranolol can be decreased when combined with Nevirapine.
ProtriptylineThe metabolism of Protriptyline can be decreased when combined with Nevirapine.
PseudoephedrineThe metabolism of Pseudoephedrine can be decreased when combined with Nevirapine.
PyrazinamideThe metabolism of Pyrazinamide can be decreased when combined with Nevirapine.
PyrimethamineThe metabolism of Nevirapine can be decreased when combined with Pyrimethamine.
QuazepamThe serum concentration of Nevirapine can be increased when it is combined with Quazepam.
QuazepamThe metabolism of Quazepam can be decreased when combined with Nevirapine.
QuetiapineThe metabolism of Quetiapine can be decreased when combined with Nevirapine.
QuinacrineThe metabolism of Quinacrine can be decreased when combined with Nevirapine.
QuinidineThe metabolism of Quinidine can be decreased when combined with Nevirapine.
QuinineThe metabolism of Quinine can be decreased when combined with Nevirapine.
RabeprazoleThe metabolism of Rabeprazole can be decreased when combined with Nevirapine.
RaloxifeneThe metabolism of Raloxifene can be decreased when combined with Nevirapine.
RamelteonThe metabolism of Ramelteon can be decreased when combined with Nevirapine.
RanitidineThe metabolism of Ranitidine can be decreased when combined with Nevirapine.
RanolazineThe serum concentration of Ranolazine can be decreased when it is combined with Nevirapine.
RanolazineThe metabolism of Nevirapine can be decreased when combined with Ranolazine.
RasagilineThe metabolism of Rasagiline can be decreased when combined with Nevirapine.
ReboxetineThe metabolism of Reboxetine can be decreased when combined with Nevirapine.
RegorafenibThe serum concentration of Regorafenib can be decreased when it is combined with Nevirapine.
RemoxiprideThe metabolism of Remoxipride can be decreased when combined with Nevirapine.
RepaglinideThe metabolism of Repaglinide can be decreased when combined with Nevirapine.
repinotanThe metabolism of repinotan can be decreased when combined with Nevirapine.
ResveratrolThe metabolism of Resveratrol can be decreased when combined with Nevirapine.
RetapamulinThe metabolism of Retapamulin can be decreased when combined with Nevirapine.
RifabutinThe serum concentration of Nevirapine can be decreased when it is combined with Rifabutin.
RifabutinThe metabolism of Rifabutin can be decreased when combined with Nevirapine.
RifampicinThe serum concentration of Nevirapine can be decreased when it is combined with Rifampicin.
RifampicinThe metabolism of Rifampicin can be decreased when combined with Nevirapine.
RifapentineThe metabolism of Nevirapine can be increased when combined with Rifapentine.
RilpivirineThe metabolism of Rilpivirine can be decreased when combined with Nevirapine.
RiluzoleThe metabolism of Riluzole can be decreased when combined with Nevirapine.
RimexoloneThe serum concentration of Rimexolone can be decreased when it is combined with Nevirapine.
RimonabantThe metabolism of Rimonabant can be decreased when combined with Nevirapine.
RiociguatThe metabolism of Riociguat can be decreased when combined with Nevirapine.
RisperidoneThe metabolism of Risperidone can be decreased when combined with Nevirapine.
RitonavirThe metabolism of Ritonavir can be decreased when combined with Nevirapine.
RivaroxabanThe serum concentration of Rivaroxaban can be decreased when it is combined with Nevirapine.
RizatriptanThe metabolism of Rizatriptan can be decreased when combined with Nevirapine.
RofecoxibThe metabolism of Rofecoxib can be decreased when combined with Nevirapine.
RoflumilastThe serum concentration of Roflumilast can be decreased when it is combined with Nevirapine.
RolapitantThe metabolism of Rolapitant can be decreased when combined with Nevirapine.
RomidepsinThe serum concentration of Romidepsin can be decreased when it is combined with Nevirapine.
RopiniroleThe metabolism of Ropinirole can be decreased when combined with Nevirapine.
RopivacaineThe metabolism of Ropivacaine can be decreased when combined with Nevirapine.
RosuvastatinThe metabolism of Rosuvastatin can be decreased when combined with Nevirapine.
RotigotineThe metabolism of Rotigotine can be decreased when combined with Nevirapine.
RoxithromycinThe metabolism of Roxithromycin can be decreased when combined with Nevirapine.
RuxolitinibThe metabolism of Ruxolitinib can be decreased when combined with Nevirapine.
SalmeterolThe serum concentration of Salmeterol can be increased when it is combined with Nevirapine.
SaquinavirThe serum concentration of Saquinavir can be decreased when it is combined with Nevirapine.
SaquinavirThe metabolism of Nevirapine can be decreased when combined with Saquinavir.
SaxagliptinThe serum concentration of Saxagliptin can be decreased when it is combined with Nevirapine.
SecobarbitalThe metabolism of Nevirapine can be increased when combined with Secobarbital.
SelegilineThe metabolism of Selegiline can be decreased when combined with Nevirapine.
SelexipagThe metabolism of Selexipag can be decreased when combined with Nevirapine.
SeratrodastThe metabolism of Seratrodast can be decreased when combined with Nevirapine.
SertindoleThe metabolism of Sertindole can be decreased when combined with Nevirapine.
SertralineThe metabolism of Sertraline can be decreased when combined with Nevirapine.
SevofluraneThe metabolism of Sevoflurane can be decreased when combined with Nevirapine.
SibutramineThe metabolism of Sibutramine can be decreased when combined with Nevirapine.
SildenafilThe metabolism of Sildenafil can be decreased when combined with Nevirapine.
SilodosinThe metabolism of Silodosin can be decreased when combined with Nevirapine.
SiltuximabThe serum concentration of Nevirapine can be decreased when it is combined with Siltuximab.
SimeprevirThe serum concentration of Nevirapine can be increased when it is combined with Simeprevir.
SimvastatinThe metabolism of Simvastatin can be decreased when combined with Nevirapine.
SirolimusThe metabolism of Sirolimus can be decreased when combined with Nevirapine.
SitagliptinThe metabolism of Sitagliptin can be decreased when combined with Nevirapine.
SolifenacinThe metabolism of Solifenacin can be decreased when combined with Nevirapine.
SonidegibThe serum concentration of Sonidegib can be decreased when it is combined with Nevirapine.
SorafenibThe serum concentration of Sorafenib can be decreased when it is combined with Nevirapine.
SorafenibThe metabolism of Nevirapine can be decreased when combined with Sorafenib.
SparteineThe metabolism of Sparteine can be decreased when combined with Nevirapine.
SpiramycinThe metabolism of Spiramycin can be decreased when combined with Nevirapine.
St. John's WortThe serum concentration of Nevirapine can be decreased when it is combined with St. John&#39;s Wort.
StiripentolThe serum concentration of Nevirapine can be increased when it is combined with Stiripentol.
SufentanilThe metabolism of Sufentanil can be decreased when combined with Nevirapine.
SulfadiazineThe metabolism of Sulfadiazine can be decreased when combined with Nevirapine.
SulfamethoxazoleThe metabolism of Sulfamethoxazole can be decreased when combined with Nevirapine.
SulfinpyrazoneThe metabolism of Sulfinpyrazone can be decreased when combined with Nevirapine.
SulfisoxazoleThe metabolism of Nevirapine can be decreased when combined with Sulfisoxazole.
SunitinibThe metabolism of Sunitinib can be decreased when combined with Nevirapine.
SuvorexantThe serum concentration of Suvorexant can be decreased when it is combined with Nevirapine.
Synthetic Conjugated Estrogens, AThe metabolism of Synthetic Conjugated Estrogens, A can be decreased when combined with Nevirapine.
Synthetic Conjugated Estrogens, BThe metabolism of Synthetic Conjugated Estrogens, B can be decreased when combined with Nevirapine.
TacrineThe metabolism of Tacrine can be decreased when combined with Nevirapine.
TacrolimusThe metabolism of Tacrolimus can be decreased when combined with Nevirapine.
TadalafilThe metabolism of Tadalafil can be decreased when combined with Nevirapine.
TamoxifenThe metabolism of Tamoxifen can be decreased when combined with Nevirapine.
TamsulosinThe metabolism of Tamsulosin can be decreased when combined with Nevirapine.
TapentadolThe metabolism of Tapentadol can be decreased when combined with Nevirapine.
TasimelteonThe serum concentration of Tasimelteon can be decreased when it is combined with Nevirapine.
TasosartanThe metabolism of Tasosartan can be decreased when combined with Nevirapine.
Taurochenodeoxycholic acidThe metabolism of Taurochenodeoxycholic acid can be decreased when combined with Nevirapine.
TegaserodThe metabolism of Tegaserod can be decreased when combined with Nevirapine.
TelaprevirThe serum concentration of Telaprevir can be decreased when it is combined with Nevirapine.
TelaprevirThe metabolism of Nevirapine can be decreased when combined with Telaprevir.
TelithromycinThe metabolism of Telithromycin can be decreased when combined with Nevirapine.
TemafloxacinThe metabolism of Temafloxacin can be decreased when combined with Nevirapine.
TemazepamThe metabolism of Temazepam can be decreased when combined with Nevirapine.
TemsirolimusThe metabolism of Temsirolimus can be decreased when combined with Nevirapine.
TeniposideThe metabolism of Teniposide can be decreased when combined with Nevirapine.
TerbinafineThe metabolism of Terbinafine can be decreased when combined with Nevirapine.
TerfenadineThe metabolism of Terfenadine can be decreased when combined with Nevirapine.
TesmilifeneThe metabolism of Tesmilifene can be decreased when combined with Nevirapine.
TestosteroneThe metabolism of Testosterone can be decreased when combined with Nevirapine.
TetrabenazineThe metabolism of Tetrabenazine can be decreased when combined with Nevirapine.
TetracyclineThe metabolism of Tetracycline can be decreased when combined with Nevirapine.
ThalidomideThe metabolism of Thalidomide can be decreased when combined with Nevirapine.
TheobromineThe metabolism of Theobromine can be decreased when combined with Nevirapine.
TheophyllineThe metabolism of Theophylline can be decreased when combined with Nevirapine.
ThiabendazoleThe metabolism of Thiabendazole can be decreased when combined with Nevirapine.
ThioridazineThe serum concentration of Thioridazine can be increased when it is combined with Nevirapine.
ThioridazineThe metabolism of Nevirapine can be decreased when combined with Thioridazine.
ThiotepaThe metabolism of Thiotepa can be decreased when combined with Nevirapine.
ThiothixeneThe metabolism of Thiothixene can be decreased when combined with Nevirapine.
TiagabineThe metabolism of Tiagabine can be decreased when combined with Nevirapine.
TicagrelorThe serum concentration of the active metabolites of Ticagrelor can be reduced when Ticagrelor is used in combination with Nevirapine resulting in a loss in efficacy.
TicagrelorThe metabolism of Nevirapine can be decreased when combined with Ticagrelor.
TiclopidineThe metabolism of Nevirapine can be decreased when combined with Ticlopidine.
TimololThe metabolism of Timolol can be decreased when combined with Nevirapine.
TinidazoleThe metabolism of Tinidazole can be decreased when combined with Nevirapine.
TiotropiumThe metabolism of Tiotropium can be decreased when combined with Nevirapine.
TipranavirThe metabolism of Tipranavir can be decreased when combined with Nevirapine.
TixocortolThe serum concentration of Tixocortol can be decreased when it is combined with Nevirapine.
TizanidineThe serum concentration of Tizanidine can be increased when it is combined with Nevirapine.
TocilizumabThe serum concentration of Nevirapine can be decreased when it is combined with Tocilizumab.
TofacitinibThe serum concentration of Tofacitinib can be decreased when it is combined with Nevirapine.
TolbutamideThe metabolism of Nevirapine can be decreased when combined with Tolbutamide.
TolterodineThe metabolism of Tolterodine can be decreased when combined with Nevirapine.
TolvaptanThe serum concentration of Tolvaptan can be increased when it is combined with Nevirapine.
ToremifeneThe serum concentration of Toremifene can be decreased when it is combined with Nevirapine.
TrabectedinThe serum concentration of Trabectedin can be increased when it is combined with Nevirapine.
TramadolThe therapeutic efficacy of Tramadol can be decreased when used in combination with Nevirapine.
TranylcypromineThe metabolism of Nevirapine can be decreased when combined with Tranylcypromine.
Trastuzumab emtansineThe metabolism of Trastuzumab emtansine can be decreased when combined with Nevirapine.
TrazodoneThe metabolism of Trazodone can be decreased when combined with Nevirapine.
TretinoinThe metabolism of Tretinoin can be decreased when combined with Nevirapine.
TriamcinoloneThe metabolism of Triamcinolone can be decreased when combined with Nevirapine.
TriamtereneThe metabolism of Triamterene can be decreased when combined with Nevirapine.
TriazolamThe metabolism of Triazolam can be decreased when combined with Nevirapine.
TrifluoperazineThe metabolism of Trifluoperazine can be decreased when combined with Nevirapine.
TrimethadioneThe metabolism of Trimethadione can be decreased when combined with Nevirapine.
TrimethoprimThe metabolism of Trimethoprim can be decreased when combined with Nevirapine.
TrimipramineThe metabolism of Trimipramine can be decreased when combined with Nevirapine.
TroglitazoneThe metabolism of Troglitazone can be decreased when combined with Nevirapine.
TroleandomycinThe metabolism of Troleandomycin can be decreased when combined with Nevirapine.
UdenafilThe metabolism of Udenafil can be decreased when combined with Nevirapine.
UlipristalThe serum concentration of Ulipristal can be increased when it is combined with Nevirapine.
UmeclidiniumThe metabolism of Umeclidinium can be decreased when combined with Nevirapine.
ValdecoxibThe metabolism of Valdecoxib can be decreased when combined with Nevirapine.
Valproic AcidThe metabolism of Nevirapine can be decreased when combined with Valproic Acid.
ValsartanThe metabolism of Nevirapine can be decreased when combined with Valsartan.
VandetanibThe serum concentration of Vandetanib can be decreased when it is combined with Nevirapine.
VanoxerineThe metabolism of Vanoxerine can be decreased when combined with Nevirapine.
VardenafilThe metabolism of Vardenafil can be decreased when combined with Nevirapine.
VemurafenibThe serum concentration of Vemurafenib can be decreased when it is combined with Nevirapine.
VenlafaxineThe metabolism of Venlafaxine can be decreased when combined with Nevirapine.
VerapamilThe metabolism of Verapamil can be decreased when combined with Nevirapine.
VicrivirocThe metabolism of Vicriviroc can be decreased when combined with Nevirapine.
VilanterolThe metabolism of Vilanterol can be decreased when combined with Nevirapine.
VilazodoneThe serum concentration of Vilazodone can be increased when it is combined with Nevirapine.
VinblastineThe metabolism of Vinblastine can be decreased when combined with Nevirapine.
VincristineThe serum concentration of Vincristine can be decreased when it is combined with Nevirapine.
VindesineThe serum concentration of Vindesine can be increased when it is combined with Nevirapine.
VinorelbineThe metabolism of Vinorelbine can be decreased when combined with Nevirapine.
VismodegibThe metabolism of Vismodegib can be decreased when combined with Nevirapine.
VorapaxarThe serum concentration of Vorapaxar can be decreased when it is combined with Nevirapine.
VoriconazoleThe metabolism of Voriconazole can be decreased when combined with Nevirapine.
VortioxetineThe metabolism of Vortioxetine can be decreased when combined with Nevirapine.
WarfarinThe metabolism of Warfarin can be decreased when combined with Nevirapine.
YohimbineThe metabolism of Yohimbine can be decreased when combined with Nevirapine.
ZafirlukastThe metabolism of Zafirlukast can be decreased when combined with Nevirapine.
ZalcitabineThe metabolism of Zalcitabine can be decreased when combined with Nevirapine.
ZaleplonThe metabolism of Zaleplon can be decreased when combined with Nevirapine.
ZidovudineThe metabolism of Zidovudine can be decreased when combined with Nevirapine.
ZileutonThe metabolism of Zileuton can be decreased when combined with Nevirapine.
ZiprasidoneThe metabolism of Ziprasidone can be decreased when combined with Nevirapine.
ZolmitriptanThe metabolism of Zolmitriptan can be decreased when combined with Nevirapine.
ZolpidemThe metabolism of Zolpidem can be decreased when combined with Nevirapine.
ZomepiracThe metabolism of Zomepirac can be decreased when combined with Nevirapine.
ZonisamideThe metabolism of Zonisamide can be decreased when combined with Nevirapine.
ZopicloneThe metabolism of Zopiclone can be decreased when combined with Nevirapine.
ZuclopenthixolThe serum concentration of Zuclopenthixol can be decreased when it is combined with Nevirapine.
Food Interactions
  • Avoid alcohol.
  • Take without regard to meals.

Targets

Kind
Protein
Organism
Human immunodeficiency virus 1
Pharmacological action
yes
Actions
inhibitor
General Function:
Rna-dna hybrid ribonuclease activity
Specific Function:
Not Available
Gene Name:
pol
Uniprot ID:
Q72547
Molecular Weight:
65223.615 Da
References
  1. Ambrose Z, Herman BD, Sheen CW, Zelina S, Moore KL, Tachedjian G, Nissley DV, Sluis-Cremer N: The human immunodeficiency virus type 1 nonnucleoside reverse transcriptase inhibitor resistance mutation I132M confers hypersensitivity to nucleoside analogs. J Virol. 2009 Apr;83(8):3826-33. doi: 10.1128/JVI.01968-08. Epub 2009 Feb 4. [PubMed:19193782 ]
  2. Nikolenko GN, Delviks-Frankenberry KA, Pathak VK: A novel molecular mechanism of dual resistance to nucleoside and nonnucleoside reverse transcriptase inhibitors. J Virol. 2010 May;84(10):5238-49. doi: 10.1128/JVI.01545-09. Epub 2010 Mar 10. [PubMed:20219933 ]
  3. Ghosn J, Chaix ML, Delaugerre C: HIV-1 resistance to first- and second-generation non-nucleoside reverse transcriptase inhibitors. AIDS Rev. 2009 Jul-Sep;11(3):165-73. [PubMed:19654858 ]

Enzymes

Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrateinhibitorinducer
General Function:
Vitamin d3 25-hydroxylase activity
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It performs a variety of oxidation reactions (e.g. caffeine 8-oxidation, omeprazole sulphoxidation, midazolam 1'-hydroxylation and midazolam 4-hydroxylation) of structurally unrelated compounds, including steroids, fatty acids, and xenobiot...
Gene Name:
CYP3A4
Uniprot ID:
P08684
Molecular Weight:
57342.67 Da
References
  1. Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. [PubMed:19515014 ]
  2. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrateinducer
General Function:
Steroid hydroxylase activity
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. Acts as a 1,4-cineole 2-exo-monooxygenase.
Gene Name:
CYP2B6
Uniprot ID:
P20813
Molecular Weight:
56277.81 Da
References
  1. Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. [PubMed:19515014 ]
  2. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrate
General Function:
Oxygen binding
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
Gene Name:
CYP3A5
Uniprot ID:
P20815
Molecular Weight:
57108.065 Da
References
  1. Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. [PubMed:19515014 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrateinhibitor
General Function:
Steroid hydroxylase activity
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. This enzyme contributes to the wide pharmacokinetics variability of the metabolism of drugs such as S-warfarin, diclofenac, phenyto...
Gene Name:
CYP2C9
Uniprot ID:
P11712
Molecular Weight:
55627.365 Da
References
  1. Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. [PubMed:19515014 ]
  2. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrate
General Function:
Steroid hydroxylase activity
Specific Function:
Exhibits a high coumarin 7-hydroxylase activity. Can act in the hydroxylation of the anti-cancer drugs cyclophosphamide and ifosphamide. Competent in the metabolic activation of aflatoxin B1. Constitutes the major nicotine C-oxidase. Acts as a 1,4-cineole 2-exo-monooxygenase. Possesses low phenacetin O-deethylation activity.
Gene Name:
CYP2A6
Uniprot ID:
P11509
Molecular Weight:
56501.005 Da
References
  1. Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. [PubMed:19515014 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrateinhibitor
General Function:
Steroid hydroxylase activity
Specific Function:
Responsible for the metabolism of many drugs and environmental chemicals that it oxidizes. It is involved in the metabolism of drugs such as antiarrhythmics, adrenoceptor antagonists, and tricyclic antidepressants.
Gene Name:
CYP2D6
Uniprot ID:
P10635
Molecular Weight:
55768.94 Da
References
  1. Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. [PubMed:19515014 ]
  2. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. Most active in catalyzing 2-hydroxylation. Caffeine is metabolized primarily by cytochrome CYP1A2 in the liver through an initial N...
Gene Name:
CYP1A2
Uniprot ID:
P05177
Molecular Weight:
58293.76 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
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Drug created on June 13, 2005 07:24 / Updated on August 30, 2016 02:13