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Identification
NameAlprazolam
Accession NumberDB00404  (APRD00280)
TypeSmall Molecule
GroupsApproved, Illicit, Investigational
DescriptionA triazolobenzodiazepine compound with antianxiety and sedative-hypnotic actions, that is efficacious in the treatment of panic disorders, with or without agoraphobia, and in generalized anxiety disorders. (From AMA Drug Evaluations Annual, 1994, p238)
Structure
Thumb
Synonyms
8-Chloro-1-methyl-6-phenyl-4H-S-triazolo(4,3-a)(1,4)benzodiazepine
Alprazolam
Xanax
External Identifiers
  • TUS-1
Approved Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Alprazolamtablet2 mg/1oralbryant ranch prepack1981-10-16Not applicableUs
Alprazolamtablet1 mg/1oralLake Erie Medical & Surgical Supply DBA Quality Care Products LLC2011-11-30Not applicableUs
Alprazolamtablet2 mgoralJamp Pharma CorporationNot applicableNot applicableCanada
Alprazolamtablet1 mg/1oralGreenstone LLC1981-10-16Not applicableUs
Alprazolamtablet0.25 mgoralJamp Pharma CorporationNot applicableNot applicableCanada
Alprazolamtablet.25 mg/1oralContract Pharmacy Services Pa1981-10-16Not applicableUs
Alprazolamtablet2 mg/1oralGreenstone LLC1981-10-16Not applicableUs
Alprazolamtablet0.25 mgoralSanis Health Inc2010-04-30Not applicableCanada
Alprazolamtablet0.5 mgoralJamp Pharma CorporationNot applicableNot applicableCanada
Alprazolamtablet.5 mg/1oralContract Pharmacy Services Pa1981-10-16Not applicableUs
Alprazolamtablet.25 mg/1oralGreenstone LLC1981-10-16Not applicableUs
Alprazolamtablet.25 mg/1oralbryant ranch prepack1981-10-16Not applicableUs
Alprazolamtablet1 mg/1oralContract Pharmacy Services Pa1981-10-16Not applicableUs
Alprazolamtablet0.50 mgoralSanis Health Inc2010-04-30Not applicableCanada
Alprazolamtablet1 mgoralJamp Pharma CorporationNot applicableNot applicableCanada
Alprazolamtablet.5 mg/1oralGreenstone LLC1981-10-16Not applicableUs
Alprazolam Tablets 0.25tablet0.25 mgoralPrempharm Inc1996-12-302005-08-05Canada
Alprazolam Tablets 0.5mgtablet0.5 mgoralPrempharm Inc1996-12-302005-08-05Canada
Alprazolam Tstablet2 mgoralPro Doc LimiteeNot applicableNot applicableCanada
Alprazolam XRtablet, extended release2 mg/1oralGreenstone LLC2003-01-17Not applicableUs
Alprazolam XRtablet, extended release3 mg/1oralGreenstone LLC2003-01-17Not applicableUs
Alprazolam XRtablet, extended release.5 mg/1oralLake Erie Medical DBA Quality Care Products LLC2003-01-17Not applicableUs
Alprazolam XRtablet, extended release1 mg/1oralLake Erie Medical DBA Quality Care Products LLC2003-01-17Not applicableUs
Alprazolam XRtablet, extended release.5 mg/1oralGreenstone LLC2003-01-17Not applicableUs
Alprazolam XRtablet, extended release2 mg/1oralLake Erie Medical & Surgical Supply DBA Quality Care Products LLC2003-01-17Not applicableUs
Alprazolam XRtablet, extended release1 mg/1oralGreenstone LLC2003-01-17Not applicableUs
Alprazolam-0.25 Tab 0.25mgtablet.25 mgoralPro Doc Limitee1991-12-31Not applicableCanada
Alprazolam-0.5 Tab 0.5mgtablet.5 mgoralPro Doc Limitee1991-12-31Not applicableCanada
Alprazolam-1tablet1 mgoralPro Doc Limitee2004-04-01Not applicableCanada
Ipg-alprazolamtablet2 mgoralMarcan Pharmaceuticals IncNot applicableNot applicableCanada
Ipg-alprazolamtablet0.25 mgoralMarcan Pharmaceuticals IncNot applicableNot applicableCanada
Ipg-alprazolamtablet0.5 mgoralMarcan Pharmaceuticals IncNot applicableNot applicableCanada
Ipg-alprazolamtablet1 mgoralMarcan Pharmaceuticals IncNot applicableNot applicableCanada
Jamp-alprazolamtablet1 mgoralJamp Pharma Corporation2014-05-15Not applicableCanada
Jamp-alprazolamtablet0.25 mgoralJamp Pharma Corporation2014-05-15Not applicableCanada
Jamp-alprazolamtablet2 mgoralJamp Pharma Corporation2015-10-25Not applicableCanada
Jamp-alprazolamtablet0.5 mgoralJamp Pharma Corporation2014-05-15Not applicableCanada
Mylan-alprazolamtablet2 mgoralMylan Pharmaceuticals Ulc1997-01-09Not applicableCanada
Mylan-alprazolamtablet0.25 mgoralMylan Pharmaceuticals Ulc1994-12-31Not applicableCanada
Mylan-alprazolamtablet1 mgoralMylan Pharmaceuticals Ulc1997-01-09Not applicableCanada
Mylan-alprazolamtablet0.5 mgoralMylan Pharmaceuticals Ulc1994-12-31Not applicableCanada
Nat-alprazolamtablet2 mgoralNatco Pharma (Canada) Inc2016-05-05Not applicableCanada
Nat-alprazolamtablet0.25 mgoralNatco Pharma (Canada) Inc2015-07-22Not applicableCanada
Nat-alprazolamtablet0.5 mgoralNatco Pharma (Canada) Inc2015-07-22Not applicableCanada
Nat-alprazolamtablet1 mgoralNatco Pharma (Canada) Inc2015-07-22Not applicableCanada
Niravamtablet, orally disintegrating1 mg/1oralJazz Pharmaceuticals, Inc.2005-04-01Not applicableUs
Niravamtablet, orally disintegrating.5 mg/1oralSTAT Rx USA LLC2005-01-20Not applicableUs
Niravamtablet, orally disintegrating2 mg/1oralJazz Pharmaceuticals, Inc.2005-04-01Not applicableUs
Niravamtablet, orally disintegrating.25 mg/1oralJazz Pharmaceuticals, Inc.2005-04-01Not applicableUs
Niravamtablet, orally disintegrating.5 mg/1oralJazz Pharmaceuticals, Inc.2005-04-01Not applicableUs
Ntp-alprazolamtablet0.5 mgoralTeva Canada LimitedNot applicableNot applicableCanada
Ntp-alprazolamtablet0.25 mgoralTeva Canada LimitedNot applicableNot applicableCanada
Nu-alpraz Tab 0.25mgtablet.25 mgoralNu Pharm Inc1991-12-312012-09-04Canada
Nu-alpraz Tab 0.5mgtablet.5 mgoralNu Pharm Inc1991-12-312012-09-04Canada
Ratio-alprazolamtablet0.5 mgoralRatiopharm Inc Division Of Teva Canada Limited1998-03-022006-08-04Canada
Ratio-alprazolamtablet0.25 mgoralRatiopharm Inc Division Of Teva Canada Limited1989-12-312006-08-04Canada
Riva-alprazolamtablet0.5 mgoralLaboratoire Riva Inc2014-11-20Not applicableCanada
Riva-alprazolamtablet2 mgoralLaboratoire Riva Inc2015-06-05Not applicableCanada
Riva-alprazolamtablet1 mgoralLaboratoire Riva Inc2014-11-20Not applicableCanada
Riva-alprazolamtablet0.25 mgoralLaboratoire Riva Inc2014-11-20Not applicableCanada
Riva-alprazolam 0.25 mgtablet0.25 mgoralLaboratoire Riva IncNot applicableNot applicableCanada
Riva-alprazolam 0.5 mgtablet0.5 mgoralLaboratoire Riva IncNot applicableNot applicableCanada
Teva-alprazolamtablet0.25 mgoralTeva Canada Limited1991-12-31Not applicableCanada
Teva-alprazolamtablet0.5 mgoralTeva Canada Limited1993-09-23Not applicableCanada
Xanaxtablet.25 mg/1oralPharmacia and Upjohn Company1981-10-16Not applicableUs
Xanaxtablet.5 mg/1oralPharmacia and Upjohn Company1981-10-16Not applicableUs
Xanaxtablet1 mg/1oralPharmacia and Upjohn Company1981-10-16Not applicableUs
Xanaxtablet2 mg/1oralPharmacia and Upjohn Company1981-10-16Not applicableUs
Xanax Tab 0.25mgtablet0.25 mgoralPfizer Canada Inc1981-12-31Not applicableCanada
Xanax Tab 0.5mgtablet0.5 mgoralPfizer Canada Inc1981-12-31Not applicableCanada
Xanax Tab 1mgtablet1 mgoralPfizer Canada Inc1993-12-31Not applicableCanada
Xanax Ts Tab 2mgtablet2 mgoralPfizer Canada Inc1993-12-31Not applicableCanada
Xanax XRtablet, extended release.5 mg/1oralPharmacia And Upjohn Company Llc2003-01-17Not applicableUs
Xanax XRtablet, extended release1 mg/1oralPharmacia And Upjohn Company Llc2003-01-17Not applicableUs
Xanax XRtablet, extended release2 mg/1oralPharmacia And Upjohn Company Llc2003-01-17Not applicableUs
Xanax XRtablet, extended release3 mg/1oralPharmacia And Upjohn Company Llc2003-01-17Not applicableUs
Approved Generic Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Alprazolamtablet, extended release1 mg/1oralProficient Rx LP2011-06-07Not applicableUs
Alprazolamtablet, extended release1 mg/1oralMedsource Pharmaceuticals2011-06-07Not applicableUs
Alprazolamtablet1 mg/1oralDispensing Solutions, Inc.2008-09-25Not applicableUs
Alprazolamtablet.5 mg/1oralA S Medication Solutions Llc2010-06-18Not applicableUs
Alprazolamtablet1 mg/1oralPreferred Pharmaceuticals, Inc.1999-12-29Not applicableUs
Alprazolamtablet1 mg/1oralA S Medication Solutions Llc2008-09-25Not applicableUs
Alprazolamtablet1 mg/1oralPreferred Pharmaceuticals, Inc.2015-04-16Not applicableUs
Alprazolamtablet.25 mg/1oralKAISER FOUNDATION HOSPITALS2008-07-14Not applicableUs
Alprazolamtablet.25 mg/1oralCardinal Health2009-12-31Not applicableUs
Alprazolamtablet, extended release.5 mg/1oralApotex Corp2008-11-12Not applicableUs
Alprazolamtablet.5 mg/1oralMylan Pharmaceuticals Inc.2010-02-25Not applicableUs
Alprazolamtablet2 mg/1oralSandoz Inc1998-03-25Not applicableUs
Alprazolamtablet1 mg/1oralSTAT Rx USA LLC2011-03-25Not applicableUs
Alprazolamtablet, extended release1 mg/1oralAidarex Pharmaceuticals LLC2009-12-03Not applicableUs
Alprazolamtablet25 mg/1oralDIRECT RX2014-01-01Not applicableUs
Alprazolamtablet1 mg/1oralMc Kesson Packaging Services A Business Unit Of Mc Kesson Corporation2014-04-29Not applicableUs
Alprazolamtablet1 mg/1oralPd Rx Pharmaceuticals, Inc.2007-03-28Not applicableUs
Alprazolamtablet, extended release1 mg/1oralAurobindo Pharma Limited2011-06-07Not applicableUs
Alprazolamtablet, orally disintegrating.5 mg/1oralPar Pharmaceutical Inc.2009-01-09Not applicableUs
Alprazolamtablet.25 mg/1oralRed Pharm Drug Inc.2008-02-01Not applicableUs
Alprazolamtablet.25 mg/1oralMylan Institutional Inc.1998-10-26Not applicableUs
Alprazolamtablet.25 mg/1oralPreferred Pharmaceuticals, Inc.2010-06-18Not applicableUs
Alprazolamsolution, concentrate1 mg/mLoralRoxane Laboratories, Inc1993-10-31Not applicableUs
Alprazolamtablet.5 mg/1oralCardinal Health2007-12-03Not applicableUs
Alprazolamtablet1 mg/1oralMc Kesson Contract Packaging2011-10-17Not applicableUs
Alprazolamtablet.5 mg/1oralGolden State Medical Supply, Inc.1993-10-19Not applicableUs
Alprazolamtablet2 mg/1oralQualitest Pharmaceuticals2008-09-25Not applicableUs
Alprazolamtablet1 mg/1oralBlenheim Pharmacal, Inc.2010-04-13Not applicableUs
Alprazolamtablet, extended release1 mg/1oralRebel Distributors Corp.2009-12-03Not applicableUs
Alprazolamtablet2 mg/1oralUnit Dose Services1995-01-03Not applicableUs
Alprazolamtablet.5 mg/1oralPreferred Pharmaceuticals, Inc.2010-03-16Not applicableUs
Alprazolamtablet.5 mg/1oralPhysicians Total Care, Inc.2007-10-26Not applicableUs
Alprazolamtablet2 mg/1oralBionpharma Inc.2015-10-01Not applicableUs
Alprazolamtablet1 mg/1oralActavis Pharma, Inc.1995-01-03Not applicableUs
Alprazolamtablet1 mg/1oralPd Rx Pharmaceuticals, Inc.2009-12-31Not applicableUs
Alprazolamtablet1 mg/1oralCardinal Health2008-04-02Not applicableUs
Alprazolamtablet.25 mg/1oralREMEDYREPACK INC.2015-03-17Not applicableUs
Alprazolamtablet, extended release1 mg/1oralMylan Pharmaceuticals Inc.2006-01-26Not applicableUs
Alprazolamtablet2 mg/1oralMajor Pharmaceuticals2008-04-02Not applicableUs
Alprazolamtablet.5 mg/1oralRebel Distributors Corp.1999-12-29Not applicableUs
Alprazolamtablet.25 mg/1oralRebel Distributors Corp2010-06-18Not applicableUs
Alprazolamtablet, extended release1 mg/1oralAmneal Pharmaceuticals, LLC2009-12-03Not applicableUs
Alprazolamtablet1 mg/1oralSun Pharma Global FZE2010-06-18Not applicableUs
Alprazolamtablet.25 mg/1oralDAVA Pharmaceuticals, Inc.2007-03-28Not applicableUs
Alprazolamtablet1 mg/1oralPd Rx Pharmaceuticals, Inc.1995-12-29Not applicableUs
Alprazolamtablet.5 mg/1oralAurobindo Pharma Limited2015-07-31Not applicableUs
Alprazolamtablet.25 mg/1oralLake Erie Medical DBA Quality Care Products LLC2010-04-01Not applicableUs
Alprazolamtablet.5 mg/1oralAphena Pharma Solutions Tennessee, Llc1995-12-29Not applicableUs
Alprazolamtablet1 mg/1oralPreferred Pharmaceuticals, Inc.2012-01-12Not applicableUs
Alprazolamtablet, extended release3 mg/1oralGlobal Pharmaceuticals, Division of Impax Laboratories Inc.2007-05-24Not applicableUs
Alprazolamtablet.25 mg/1oralCardinal Health2013-09-04Not applicableUs
Alprazolamtablet.5 mg/1oralApotex Corp.2007-01-19Not applicableUs
Alprazolamtablet, orally disintegrating1 mg/1oralActavis Elizabeth LLC2010-03-16Not applicableUs
Alprazolamtablet.25 mg/1oralSandoz Inc1995-12-29Not applicableUs
Alprazolamtablet.5 mg/1oralApotheca, Inc2000-01-18Not applicableUs
Alprazolamtablet1 mg/1oralAidarex Pharmaceuticals LLC2007-03-28Not applicableUs
Alprazolamtablet, extended release.5 mg/1oralProficient Rx LP2006-01-26Not applicableUs
Alprazolamtablet2 mg/1oralBoca Pharmacal, LLC2010-10-15Not applicableUs
Alprazolamtablet1 mg/1oralLake Erie Medical & Surgical Supply DBA Quality Care Products LLC1995-12-29Not applicableUs
Alprazolamtablet, extended release.5 mg/1oralProficient Rx LP2011-06-07Not applicableUs
Alprazolamtablet2 mg/1oralMedsource Pharmaceuticals1995-01-03Not applicableUs
Alprazolamtablet.25 mg/1oralContract Pharmacy Services Pa2011-03-25Not applicableUs
Alprazolamtablet1 mg/1oralA S Medication Solutions Llc2010-06-18Not applicableUs
Alprazolamtablet.25 mg/1oralPreferred Pharmaceuticals, Inc.1999-12-29Not applicableUs
Alprazolamtablet2 mg/1oralA S Medication Solutions Llc2010-10-15Not applicableUs
Alprazolamtablet.25 mg/1oralBionpharma Inc.2015-10-01Not applicableUs
Alprazolamtablet.5 mg/1oralKAISER FOUNDATION HOSPITALS2008-07-14Not applicableUs
Alprazolamtablet.25 mg/1oralCardinal Health1993-10-31Not applicableUs
Alprazolamtablet.25 mg/1oralPreferred Pharmaceuticals, Inc.2016-03-01Not applicableUs
Alprazolamtablet, extended release1 mg/1oralApotex Corp2008-11-12Not applicableUs
Alprazolamtablet1 mg/1oralMylan Pharmaceuticals Inc.1994-01-28Not applicableUs
Alprazolamtablet.25 mg/1oralMajor Pharmaceuticals2008-04-02Not applicableUs
Alprazolamtablet.25 mg/1oralSTAT Rx USA LLC1993-10-31Not applicableUs
Alprazolamtablet2 mg/1oralBlenheim Pharmacal, Inc.2010-04-23Not applicableUs
Alprazolamtablet, extended release2 mg/1oralRebel Distributors Corp.2009-12-03Not applicableUs
Alprazolamtablet1 mg/1oralDIRECT RX2015-01-01Not applicableUs
Alprazolamtablet.25 mg/1oralBoca Pharmacal, LLC2010-10-15Not applicableUs
Alprazolamtablet.5 mg/1oralPd Rx Pharmaceuticals, Inc.2007-03-28Not applicableUs
Alprazolamtablet, extended release2 mg/1oralAurobindo Pharma Limited2011-06-07Not applicableUs
Alprazolamtablet, orally disintegrating1 mg/1oralPar Pharmaceutical Inc.2009-01-09Not applicableUs
Alprazolamtablet.5 mg/1oralRed Pharm2008-06-01Not applicableUs
Alprazolamtablet.5 mg/1oralMylan Institutional Inc.1998-10-23Not applicableUs
Alprazolamtablet2 mg/1oralPreferred Pharmaceuticals Inc.2015-10-19Not applicableUs
Alprazolamtablet, extended release.5 mg/1oralGlobal Pharmaceuticals, Division of Impax Laboratories Inc.2007-05-24Not applicableUs
Alprazolamtablet.25 mg/1oralCardinal Health2007-03-28Not applicableUs
Alprazolamtablet.25 mg/1oralAmerican Health Packaging2013-05-282015-12-29Us
Alprazolamtablet1 mg/1oralGolden State Medical Supply, Inc.1993-10-19Not applicableUs
Alprazolamtablet.25 mg/1oralNcs Health Care Of Ky, Inc Dba Vangard Labs1995-01-03Not applicableUs
Alprazolamtablet, extended release2 mg/1oralAmneal Pharmaceuticals, LLC2009-12-03Not applicableUs
Alprazolamtablet2 mg/1oralSun Pharma Global FZE2010-06-18Not applicableUs
Alprazolamtablet.5 mg/1oralDAVA Pharmaceuticals, Inc.2007-03-28Not applicableUs
Alprazolamtablet.25 mg/1oralUnit Dose Services1995-12-29Not applicableUs
Alprazolamtablet1 mg/1oralPreferred Pharmaceuticals, Inc.2010-03-16Not applicableUs
Alprazolamtablet1 mg/1oralPhysicians Total Care, Inc.2006-09-13Not applicableUs
Alprazolamtablet.5 mg/1oralLife Line Home Care Services, Inc.2012-01-26Not applicableUs
Alprazolamtablet2 mg/1oralActavis Pharma, Inc.1995-01-03Not applicableUs
Alprazolamtablet.5 mg/1oralPd Rx Pharmaceuticals, Inc.2008-09-25Not applicableUs
Alprazolamtablet.5 mg/1oralCardinal Health2008-04-02Not applicableUs
Alprazolamtablet.5 mg/1oralDIRECT RX2014-01-01Not applicableUs
Alprazolamtablet.25 mg/1oralQualitest Pharmaceuticals2008-09-25Not applicableUs
Alprazolamtablet.25 mg/1oralBlenheim Pharmacal, Inc.2010-12-10Not applicableUs
Alprazolamtablet1 mg/1oralRebel Distributors Corp.1999-12-29Not applicableUs
Alprazolamtablet1 mg/1oralRebel Distributors Corp2010-06-18Not applicableUs
Alprazolamtablet1 mg/1oralProficient Rx LP1995-12-29Not applicableUs
Alprazolamtablet.5 mg/1oralMedsource Pharmaceuticals2008-09-25Not applicableUs
Alprazolamtablet1 mg/1oralAurobindo Pharma Limited2015-07-31Not applicableUs
Alprazolamtablet2 mg/1oralLake Erie Medical DBA Quality Care Products LLC2010-04-01Not applicableUs
Alprazolamtablet.25 mg/1oralAmerican Health Packaging2013-09-04Not applicableUs
Alprazolamtablet.25 mg/1oralA S Medication Solutions Llc2008-09-25Not applicableUs
Alprazolamtablet.5 mg/1oralPreferred Pharmaceuticals, Inc.2012-01-12Not applicableUs
Alprazolamtablet.25 mg/1oralKAISER FOUNDATION HOSPITALS2011-06-08Not applicableUs
Alprazolamtablet.5 mg/1oralCardinal Health2009-12-31Not applicableUs
Alprazolamtablet1 mg/1oralApotex Corp.2007-01-19Not applicableUs
Alprazolamtablet, orally disintegrating2 mg/1oralActavis Elizabeth LLC2010-03-16Not applicableUs
Alprazolamtablet.5 mg/1oralSandoz Inc1995-12-29Not applicableUs
Alprazolamtablet1 mg/1oralApotheca, Inc2012-06-30Not applicableUs
Alprazolamtablet2 mg/1oralAidarex Pharmaceuticals LLC2007-03-28Not applicableUs
Alprazolamtablet.5 mg/1oralMajor Pharmaceuticals2008-04-02Not applicableUs
Alprazolamtablet1 mg/1oralLake Erie Medical & Surgical Supply DBA Quality Care Products LLC2010-06-18Not applicableUs
Alprazolamtablet.5 mg/1oralTYA Pharmaceuticals2010-06-18Not applicableUs
Alprazolamtablet.25 mg/1oralSun Pharma Global FZE2010-06-18Not applicableUs
Alprazolamtablet.5 mg/1oralContract Pharmacy Services Pa2011-03-25Not applicableUs
Alprazolamtablet2 mg/1oralA S Medication Solutions Llc2010-10-15Not applicableUs
Alprazolamtablet.5 mg/1oralPreferred Pharmaceuticals, Inc.1999-12-29Not applicableUs
Alprazolamtablet, extended release1 mg/1oralA S Medication Solutions Llc2011-05-04Not applicableUs
Alprazolamtablet.5 mg/1oralBionpharma Inc.2015-10-01Not applicableUs
Alprazolamtablet.25 mg/1oralActavis Pharma, Inc.1995-01-03Not applicableUs
Alprazolamtablet.5 mg/1oralCardinal Health1993-10-31Not applicableUs
Alprazolamtablet2 mg/1oralPd Rx Pharmaceuticals, Inc.1998-03-25Not applicableUs
Alprazolamtablet, extended release2 mg/1oralApotex Corp2008-11-12Not applicableUs
Alprazolamtablet2 mg/1oralMylan Pharmaceuticals Inc.1994-01-28Not applicableUs
Alprazolamtablet2 mg/1oralGolden State Medical Supply, Inc.1993-10-19Not applicableUs
Alprazolamtablet, orally disintegrating.25 mg/1oralActavis Elizabeth LLC2010-03-16Not applicableUs
Alprazolamtablet.5 mg/1oralNcs Health Care Of Ky, Inc Dba Vangard Labs1995-01-03Not applicableUs
Alprazolamtablet.25 mg/1oralBlenheim Pharmacal, Inc.2013-05-22Not applicableUs
Alprazolamtablet, extended release2 mg/1oralRebel Distributors Corp.2009-12-03Not applicableUs
Alprazolamtablet.5 mg/1oralProficient Rx LP1995-12-29Not applicableUs
Alprazolamtablet.5 mg/1oralBoca Pharmacal, LLC2010-10-15Not applicableUs
Alprazolamtablet.25 mg/1oralPd Rx Pharmaceuticals, Inc.2007-03-28Not applicableUs
Alprazolamtablet, extended release3 mg/1oralAurobindo Pharma Limited2011-06-07Not applicableUs
Alprazolamtablet, orally disintegrating2 mg/1oralPar Pharmaceutical Inc.2009-01-09Not applicableUs
Alprazolamtablet.25 mg/1oralAphena Pharma Solutions Tennessee, Llc1995-12-29Not applicableUs
Alprazolamtablet1 mg/1oralMylan Institutional Inc.1998-10-23Not applicableUs
Alprazolamtablet, extended release1 mg/1oralPreferred Pharmaceuticals, Inc.2013-04-22Not applicableUs
Alprazolamtablet, extended release1 mg/1oralGlobal Pharmaceuticals, Division of Impax Laboratories Inc.2007-05-24Not applicableUs
Alprazolamtablet.5 mg/1oralCardinal Health2007-03-28Not applicableUs
Alprazolamtablet.5 mg/1oralAmerican Health Packaging2013-05-282015-12-29Us
Alprazolamtablet.25 mg/1oralMc Kesson Packaging Services A Business Unit Of Mc Kesson Corporation2014-04-29Not applicableUs
Alprazolamtablet, extended release3 mg/1oralAmneal Pharmaceuticals, LLC2009-12-03Not applicableUs
Alprazolamtablet.5 mg/1oralREMEDYREPACK INC.2011-04-21Not applicableUs
Alprazolamtablet1 mg/1oralDAVA Pharmaceuticals, Inc.2007-03-28Not applicableUs
Alprazolamtablet.5 mg/1oralUnit Dose Services1995-12-29Not applicableUs
Alprazolamtablet1 mg/1oralPreferred Pharmaceuticals, Inc.2014-10-20Not applicableUs
Alprazolamtablet2 mg/1oralPhysicians Total Care, Inc.2009-09-16Not applicableUs
Alprazolamtablet.25 mg/1oralMc Kesson Contract Packaging2011-10-24Not applicableUs
Alprazolamtablet.25 mg/1oralPd Rx Pharmaceuticals, Inc.2008-09-25Not applicableUs
Alprazolamtablet1 mg/1oralDIRECT RX2014-01-01Not applicableUs
Alprazolamtablet.5 mg/1oralQualitest Pharmaceuticals2008-09-25Not applicableUs
Alprazolamtablet.25 mg/1oralBlenheim Pharmacal, Inc.2011-09-14Not applicableUs
Alprazolamtablet2 mg/1oralRebel Distributors Corp.1998-03-25Not applicableUs
Alprazolamtablet.5 mg/1oralPd Rx Pharmaceuticals, Inc.2009-12-31Not applicableUs
Alprazolamtablet2 mg/1oralProficient Rx LP1998-03-25Not applicableUs
Alprazolamtablet1 mg/1oralMedsource Pharmaceuticals1995-12-29Not applicableUs
Alprazolamtablet2 mg/1oralAurobindo Pharma Limited2015-07-31Not applicableUs
Alprazolamtablet.25 mg/1oralA S Medication Solutions Llc2010-06-18Not applicableUs
Alprazolamtablet.5 mg/1oralAmerican Health Packaging2013-09-04Not applicableUs
Alprazolamtablet.5 mg/1oralA S Medication Solutions Llc2008-09-25Not applicableUs
Alprazolamtablet.25 mg/1oralPreferred Pharmaceuticals, Inc.2012-01-12Not applicableUs
Alprazolamtablet.5 mg/1oralKAISER FOUNDATION HOSPITALS2011-06-08Not applicableUs
Alprazolamtablet1 mg/1oralCardinal Health2009-12-31Not applicableUs
Alprazolamtablet2 mg/1oralApotex Corp.2007-01-19Not applicableUs
Alprazolamtablet.25 mg/1oralMylan Pharmaceuticals Inc.2012-07-23Not applicableUs
Alprazolamtablet1 mg/1oralSandoz Inc1995-12-29Not applicableUs
Alprazolamtablet.5 mg/1oralSTAT Rx USA LLC2011-03-25Not applicableUs
Alprazolamtablet.25 mg/1oralAidarex Pharmaceuticals LLC2007-03-28Not applicableUs
Alprazolamtablet.5 mg/1oralActavis Pharma, Inc.1995-01-03Not applicableUs
Alprazolamtablet1 mg/1oralCardinal Health1993-10-31Not applicableUs
Alprazolamtablet.25 mg/1oralCardinal Health2008-04-02Not applicableUs
Alprazolamtablet, extended release3 mg/1oralApotex Corp2008-11-12Not applicableUs
Alprazolamtablet, extended release.5 mg/1oralMylan Pharmaceuticals Inc.2006-01-26Not applicableUs
Alprazolamtablet1 mg/1oralMajor Pharmaceuticals2008-04-02Not applicableUs
Alprazolamtablet.25 mg/1oralRebel Distributors Corp.1999-12-29Not applicableUs
Alprazolamtablet.25 mg/1oralRebel Distributors Corp2010-06-18Not applicableUs
Alprazolamtablet1 mg/1oralbryant ranch prepack2008-04-02Not applicableUs
Alprazolamtablet, extended release.5 mg/1oralAmneal Pharmaceuticals, LLC2009-12-03Not applicableUs
Alprazolamtablet.5 mg/1oralSun Pharma Global FZE2010-06-18Not applicableUs
Alprazolamtablet1 mg/1oralContract Pharmacy Services Pa2011-03-25Not applicableUs
Alprazolamtablet.25 mg/1oralA S Medication Solutions Llc2010-10-15Not applicableUs
Alprazolamtablet.25 mg/1oralPreferred Pharmaceuticals, Inc.2010-03-16Not applicableUs
Alprazolamtablet.25 mg/1oralPhysicians Total Care, Inc.2005-03-17Not applicableUs
Alprazolamtablet1 mg/1oralBionpharma Inc.2015-10-01Not applicableUs
Alprazolamtablet2 mg/1oralREMEDYREPACK INC.2014-05-12Not applicableUs
Alprazolamtablet, extended release1 mg/1oralPreferred Pharmaceuticals, Inc.2012-11-15Not applicableUs
Alprazolamtablet, extended release2 mg/1oralGlobal Pharmaceuticals, Division of Impax Laboratories Inc.2007-05-24Not applicableUs
Alprazolamtablet1 mg/1oralCardinal Health2007-03-28Not applicableUs
Alprazolamtablet1 mg/1oralAmerican Health Packaging2013-05-282015-12-29Us
Alprazolamtablet.25 mg/1oralApotex Corp.2007-01-19Not applicableUs
Alprazolamtablet, orally disintegrating.5 mg/1oralActavis Elizabeth LLC2010-03-16Not applicableUs
Alprazolamtablet1 mg/1oralNcs Health Care Of Ky, Inc Dba Vangard Labs1995-01-03Not applicableUs
Alprazolamtablet.25 mg/1oralBlenheim Pharmacal, Inc.2013-11-15Not applicableUs
Alprazolamtablet.5 mg/1oralAidarex Pharmaceuticals LLC2007-03-28Not applicableUs
Alprazolamtablet1 mg/1oralProficient Rx LP1994-01-28Not applicableUs
Alprazolamtablet1 mg/1oralBoca Pharmacal, LLC2010-10-15Not applicableUs
Alprazolamtablet1 mg/1oralPd Rx Pharmaceuticals, Inc.2008-09-25Not applicableUs
Alprazolamtablet.25 mg/1oralAurobindo Pharma Limited2015-07-31Not applicableUs
Alprazolamtablet.5 mg/1oralLake Erie Medical DBA Quality Care Products LLC2010-04-01Not applicableUs
Alprazolamtablet1 mg/1oralAphena Pharma Solutions Tennessee, Llc1995-12-29Not applicableUs
Alprazolamtablet.5 mg/1oralMc Kesson Packaging Services A Business Unit Of Mc Kesson Corporation2014-04-29Not applicableUs
Alprazolamtablet, extended release.5 mg/1oralAurobindo Pharma Limited2011-06-07Not applicableUs
Alprazolamtablet, orally disintegrating.25 mg/1oralPar Pharmaceutical Inc.2009-01-09Not applicableUs
Alprazolamtablet2 mg/1oralDAVA Pharmaceuticals, Inc.2007-03-28Not applicableUs
Alprazolamtablet1 mg/1oralUnit Dose Services1995-12-29Not applicableUs
Alprazolamtablet.5 mg/1oralPreferred Pharmaceuticals, Inc.2010-06-18Not applicableUs
Alprazolamtablet.25 mg/1oralCardinal Health2007-12-03Not applicableUs
Alprazolamtablet.5 mg/1oralMc Kesson Contract Packaging2011-10-17Not applicableUs
Alprazolamtablet.25 mg/1oralGolden State Medical Supply, Inc.1993-10-19Not applicableUs
Alprazolamtablet.25 mg/1oralDIRECT RX2014-01-01Not applicableUs
Alprazolamtablet1 mg/1oralQualitest Pharmaceuticals2008-09-25Not applicableUs
Alprazolamtablet.25 mg/1oralBlenheim Pharmacal, Inc.2009-12-16Not applicableUs
Alprazolamtablet, extended release.5 mg/1oralRebel Distributors Corp.2009-12-03Not applicableUs
Alprazolamtablet.25 mg/1oralPd Rx Pharmaceuticals, Inc.2011-09-07Not applicableUs
Alprazolam ERtablet, extended release2 mg/1oralSTAT Rx USA LLC2007-03-28Not applicableUs
Alprazolam Extended Releasetablet, extended release2 mg/1oralCore Pharma, Llc2007-03-282016-03-16Us
Alprazolam Extended Releasetablet, extended release3 mg/1oralActavis Elizabeth LLC2007-02-13Not applicableUs
Alprazolam Extended Releasetablet, extended release3 mg/1oralCore Pharma, Llc2007-03-282016-03-16Us
Alprazolam Extended Releasetablet, extended release2 mg/1oralActavis Elizabeth LLC2007-02-13Not applicableUs
Alprazolam Extended Releasetablet, extended release.5 mg/1oralbryant ranch prepack2007-02-13Not applicableUs
Alprazolam Extended Releasetablet, extended release.5 mg/1oralCore Pharma, Llc2007-03-282016-03-16Us
Alprazolam Extended Releasetablet, extended release.5 mg/1oralActavis Elizabeth LLC2007-02-13Not applicableUs
Alprazolam Extended Releasetablet, extended release1 mg/1oralCore Pharma, Llc2007-03-282016-03-16Us
Alprazolam Extended Releasetablet, extended release1 mg/1oralActavis Elizabeth LLC2007-02-13Not applicableUs
Alprazolam Extended-releasetablet, extended release.5 mg/1oralbryant ranch prepack2007-03-28Not applicableUs
Alprazolam Extended-releasetablet, extended release1 mg/1oralH.J. Harkins Company, Inc.2007-03-28Not applicableUs
Alprazolam Extended-releasetablet, extended release.5 mg/1oralbryant ranch prepack2007-03-28Not applicableUs
Apo-alpraztablet1 mgoralApotex Inc2001-04-16Not applicableCanada
Apo-alpraz Tab 0.25mgtablet0.25 mgoralApotex Inc1990-12-31Not applicableCanada
Apo-alpraz Tab 0.5mgtablet.5 mgoralApotex Inc1990-12-31Not applicableCanada
Apo-alpraz Tstablet2 mgoralApotex Inc2001-04-16Not applicableCanada
Approved Over the Counter ProductsNot Available
Unapproved/Other Products Not Available
International Brands
NameCompany
AlplaxNot Available
AlprazolanNot Available
AlpronaxNot Available
AlproxNot Available
AlvizNot Available
CassadanNot Available
EsparonNot Available
RalozamNot Available
RestylNot Available
SolanaxNot Available
TafilNot Available
TrankimazinNot Available
TranquinalNot Available
XanorNot Available
Brand mixtures
NameLabellerIngredients
GabazolaminePhysician Therapeutics Llc
Gabazolamine-0.5Physician Therapeutics Llc
Sentrazolam AmPhysician Therapeutics Llc
SaltsNot Available
Categories
UNIIYU55MQ3IZY
CAS number28981-97-7
WeightAverage: 308.765
Monoisotopic: 308.082874143
Chemical FormulaC17H13ClN4
InChI KeyInChIKey=VREFGVBLTWBCJP-UHFFFAOYSA-N
InChI
InChI=1S/C17H13ClN4/c1-11-20-21-16-10-19-17(12-5-3-2-4-6-12)14-9-13(18)7-8-15(14)22(11)16/h2-9H,10H2,1H3
IUPAC Name
12-chloro-3-methyl-9-phenyl-2,4,5,8-tetraazatricyclo[8.4.0.0²,⁶]tetradeca-1(10),3,5,8,11,13-hexaene
SMILES
CC1=NN=C2CN=C(C3=CC=CC=C3)C3=C(C=CC(Cl)=C3)N12
Taxonomy
DescriptionThis compound belongs to the class of organic compounds known as 1,4-benzodiazepines. These are organic compounds containing a benzene ring fused to a 1,4-azepine.
KingdomOrganic compounds
Super ClassOrganoheterocyclic compounds
ClassBenzodiazepines
Sub Class1,4-benzodiazepines
Direct Parent1,4-benzodiazepines
Alternative Parents
Substituents
  • 1,4-benzodiazepine
  • Phenyl-1,3,4-triazole
  • Phenyl-1,2,4-triazole
  • Phenyltriazole
  • Chlorobenzene
  • Benzenoid
  • Monocyclic benzene moiety
  • Aryl halide
  • Aryl chloride
  • Heteroaromatic compound
  • 1,2,4-triazole
  • Triazole
  • Azole
  • Ketimine
  • Azacycle
  • Organic 1,3-dipolar compound
  • Propargyl-type 1,3-dipolar organic compound
  • Hydrocarbon derivative
  • Organonitrogen compound
  • Organochloride
  • Organohalogen compound
  • Imine
  • Aromatic heteropolycyclic compound
Molecular FrameworkAromatic heteropolycyclic compounds
External Descriptors
Pharmacology
IndicationFor the management of anxiety disorder or the short-term relief of symptoms of anxiety and for the treatment of panic disorder, with or without agoraphobia.
PharmacodynamicsAlprazolam, a benzodiazepine, is used to treat panic disorder and anxiety disorder. Unlike chlordiazepoxide, clorazepate, and prazepam, alprazolam has a shorter half-life and metabolites with minimal activity. Like other triazolo benzodiazepines such as triazolam, alprazolam may have significant drug interactions involving the hepatic cytochrome P-450 3A4 isoenzyme. Clinically, all benzodiazepines cause a dose-related central nervous system depressant activity varying from mild impairment of task performance to hypnosis. Unlike other benzodiazepines, alprazolam may also have some antidepressant activity, although clinical evidence of this is lacking.
Mechanism of actionBenzodiazepines bind nonspecifically to benzodiazepine receptors BNZ1, which mediates sleep, and BNZ2, which affects muscle relaxation, anticonvulsant activity, motor coordination, and memory. As benzodiazepine receptors are thought to be coupled to gamma-aminobutyric acid-A (GABAA) receptors, this enhances the effects of GABA by increasing GABA affinity for the GABA receptor. Binding of the inhibitory neurotransmitter GABA to the site opens the chloride channel, resulting in a hyperpolarized cell membrane that prevents further excitation of the cell.
Related Articles
AbsorptionReadily absorbed from the gastrointestinal tract. Bioavailability is 80-90%.
Volume of distributionNot Available
Protein binding80% (mainly to albumin)
Metabolism

Hepatic. Hydroxylated in the liver to α-hydroxyalprazolam, which is also active. This and other metabolites are later excreted in urine as glucuronides.

SubstrateEnzymesProduct
Alprazolam
alpha-HydroxyalprazolamDetails
Alprazolam
4-hydroxyalprazolamDetails
Route of eliminationAlprazolam and its metabolites are excreted primarily in the urine.
Half life6.3-26.9 hours
Clearance
  • 2.13 +/- 0.54 mL/min/kg [CYP3A inducers]
  • 0.90 +/- 0.21 mL/min/kg [without CYP3A inducers]
ToxicityOral, mouse: LD50=1020 mg/kg. Symptoms of overdose include confusion, coma, impaired coordination, sleepiness, and slowed reaction time.
Affected organisms
  • Humans and other mammals
PathwaysNot Available
SNP Mediated EffectsNot Available
SNP Mediated Adverse Drug ReactionsNot Available
ADMET
Predicted ADMET features
PropertyValueProbability
Human Intestinal Absorption+1.0
Blood Brain Barrier+0.9794
Caco-2 permeable+0.8867
P-glycoprotein substrateNon-substrate0.5099
P-glycoprotein inhibitor INon-inhibitor0.7301
P-glycoprotein inhibitor IIInhibitor0.8354
Renal organic cation transporterInhibitor0.7688
CYP450 2C9 substrateNon-substrate0.7907
CYP450 2D6 substrateNon-substrate0.9164
CYP450 3A4 substrateSubstrate0.7353
CYP450 1A2 substrateInhibitor0.8758
CYP450 2C9 inhibitorInhibitor0.8076
CYP450 2D6 inhibitorNon-inhibitor0.8137
CYP450 2C19 inhibitorInhibitor0.6519
CYP450 3A4 inhibitorNon-inhibitor0.6308
CYP450 inhibitory promiscuityHigh CYP Inhibitory Promiscuity0.8913
Ames testNon AMES toxic0.8957
CarcinogenicityNon-carcinogens0.6779
BiodegradationNot ready biodegradable1.0
Rat acute toxicity2.3717 LD50, mol/kg Not applicable
hERG inhibition (predictor I)Weak inhibitor0.973
hERG inhibition (predictor II)Non-inhibitor0.8733
ADMET data is predicted using admetSAR, a free tool for evaluating chemical ADMET properties. (23092397 )
Pharmacoeconomics
Manufacturers
  • Roxane laboratories inc
  • Actavis elizabeth llc
  • Amneal pharmaceuticals ny llc
  • Apotex inc
  • Barr laboratories inc
  • Corepharma llc
  • Impax laboratories inc
  • Mylan pharmaceuticals inc
  • Sandoz inc
  • Teva pharmaceuticals usa
  • Vintage pharmaceuticals llc
  • Watson laboratories inc florida
  • Zydus pharmaceuticals usa inc
  • Pharmacia and upjohn
  • Par pharmaceutical inc
  • Schwarz pharma inc
  • Alphapharm party ltd
  • Dava international inc
  • Ivax pharmaceuticals inc sub teva pharmaceuticals usa
  • Sun pharma global inc
  • Teva pharmaceuticals usa inc
  • Watson laboratories inc
  • Pharmacia and upjohn co
Packagers
Dosage forms
FormRouteStrength
Solution, concentrateoral1 mg/mL
Tabletoral0.50 mg
Tabletoral25 mg/1
Tablet, extended releaseoral.5 mg/1
Tablet, extended releaseoral1 mg/1
Tablet, extended releaseoral2 mg/1
Tablet, extended releaseoral3 mg/1
Tablet, orally disintegratingoral.25 mg/1
Tablet, orally disintegratingoral.5 mg/1
Tablet, orally disintegratingoral1 mg/1
Tablet, orally disintegratingoral2 mg/1
Tabletoral.25 mg
Tabletoral0.25 mg
Tabletoral.5 mg
Kit
Tabletoral0.5 mg
Tabletoral.25 mg/1
Tabletoral.5 mg/1
Tabletoral1 mg/1
Tabletoral2 mg/1
Tabletoral1 mg
Tabletoral2 mg
Prices
Unit descriptionCostUnit
ALPRAZolam Intensol 1 mg/ml Concentrate 30ml Bottle67.03USD bottle
Niravam 2 mg Dispersible Tablet8.53USD dispersible tablet
Xanax xr 3 mg tablet7.25USD tablet
Xanax XR 3 mg 24 Hour tablet7.1USD tablet
Niravam 2 mg tablet6.86USD tablet
Niravam 1 mg Dispersible Tablet5.42USD dispersible tablet
Xanax xr 2 mg tablet4.84USD tablet
Xanax XR 2 mg 24 Hour tablet4.73USD tablet
Niravam 0.5 mg Dispersible Tablet4.2USD dispersible tablet
Niravam 1 mg tablet4.04USD tablet
Xanax 2 mg tablet3.82USD tablet
ALPRAZolam 3 mg 24 Hour tablet3.67USD tablet
Xanax XR 1 mg 24 Hour tablet3.64USD tablet
Xanax xr 1 mg tablet3.64USD tablet
Niravam 0.25 mg Dispersible Tablet3.45USD dispersible tablet
Niravam 0.5 mg tablet3.02USD tablet
Xanax XR 0.5 mg 24 Hour tablet3.01USD tablet
Xanax xr 0.5 mg tablet2.93USD tablet
ALPRAZolam 2 mg 24 Hour tablet2.53USD tablet
Niravam 0.25 mg tablet2.43USD tablet
ALPRAZolam 1 mg 24 Hour tablet2.33USD tablet
Xanax 1 mg tablet2.29USD tablet
Alprazolam 1 mg/ml oral conc2.23USD ml
Xanax 0.5 mg tablet1.3USD tablet
Alprazolam 2 mg tablet1.22USD tablet
Xanax 0.25 mg tablet1.09USD tablet
ALPRAZolam 0.5 mg 24 Hour tablet1.07USD tablet
Alprazolam 1 mg tablet0.78USD tablet
Alprazolam 0.5 mg tablet0.67USD tablet
Alprazolam 0.25 mg tablet0.55USD tablet
Apo-Alpraz 0.5 mg Tablet0.1USD tablet
Mylan-Alprazolam 0.5 mg Tablet0.1USD tablet
Novo-Alprazol 0.5 mg Tablet0.1USD tablet
Apo-Alpraz 0.25 mg Tablet0.08USD tablet
Mylan-Alprazolam 0.25 mg Tablet0.08USD tablet
Novo-Alprazol 0.25 mg Tablet0.08USD tablet
DrugBank does not sell nor buy drugs. Pricing information is supplied for informational purposes only.
Patents
Patent NumberPediatric ExtensionApprovedExpires (estimated)
US6024981 No1998-04-092018-04-09Us
US6221392 No1998-04-092018-04-09Us
Properties
StateSolid
Experimental Properties
PropertyValueSource
melting point228-229.5 °CHester, J.B., Jr.; US. Patent3,681,343; August 1,1972; assigned to The Upjohn Company. Hester, J.B., Jr.; US.Patent3,781,289; December 25,1973;assigned to The Upjohn Company. Hester, J.B., Jr.; U S . Patent 3,709898; January 9,1973; assigned t o The Upjohn Company.
water solubility40 mg/L at pH 7; 12 mg/mL at pH 1.2Not Available
logP2.12BIOBYTE (1995)
Predicted Properties
PropertyValueSource
Water Solubility0.0324 mg/mLALOGPS
logP2.23ALOGPS
logP2.37ChemAxon
logS-4ALOGPS
pKa (Strongest Acidic)18.3ChemAxon
pKa (Strongest Basic)5.08ChemAxon
Physiological Charge0ChemAxon
Hydrogen Acceptor Count3ChemAxon
Hydrogen Donor Count0ChemAxon
Polar Surface Area43.07 Å2ChemAxon
Rotatable Bond Count1ChemAxon
Refractivity98.88 m3·mol-1ChemAxon
Polarizability32.22 Å3ChemAxon
Number of Rings4ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleYesChemAxon
Spectra
Mass Spec (NIST)Not Available
Spectra
Spectrum TypeDescriptionSplash Key
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, PositiveNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, PositiveNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, PositiveNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, NegativeNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, NegativeNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, NegativeNot Available
MSMass Spectrum (Electron Ionization)splash10-0kdi-4792000000-9f1cdda14e36000955d3View in MoNA
References
Synthesis Reference

Hester, J.B., Jr.; US. Patent 3,681,343; August 1,1972; assigned to The Upjohn Company. Hester, J.B., Jr.; US.Patent 3,781,289; December 25,1973;assigned to The Upjohn Company. Hester, J.B., Jr.; U S . Patent 3,709898; January 9,1973; assigned to The Upjohn Company.

General References
  1. Risse SC, Whitters A, Burke J, Chen S, Scurfield RM, Raskind MA: Severe withdrawal symptoms after discontinuation of alprazolam in eight patients with combat-induced posttraumatic stress disorder. J Clin Psychiatry. 1990 May;51(5):206-9. [PubMed:2335496 ]
  2. Wolf B, Griffiths RR: Physical dependence on benzodiazepines: differences within the class. Drug Alcohol Depend. 1991 Dec 31;29(2):153-6. [PubMed:1686752 ]
  3. Haque W, Watson DJ, Bryant SG: Death following suspected alprazolam withdrawal seizures: a case report. Tex Med. 1990 Jan;86(1):44-7. [PubMed:2300914 ]
  4. Hori A: Pharmacotherapy for personality disorders. Psychiatry Clin Neurosci. 1998 Feb;52(1):13-9. [PubMed:9682928 ]
  5. Garcia-Algar O, Lopez-Vilchez MA, Martin I, Mur A, Pellegrini M, Pacifici R, Rossi S, Pichini S: Confirmation of gestational exposure to alprazolam by analysis of biological matrices in a newborn with neonatal sepsis. Clin Toxicol (Phila). 2007;45(3):295-8. [PubMed:17453885 ]
External Links
ATC CodesN05BA12
AHFS Codes
  • 28:24.08
PDB EntriesNot Available
FDA labelDownload (63.6 KB)
MSDSDownload (47.3 KB)
Interactions
Drug Interactions
Drug
1,10-PhenanthrolineThe serum concentration of Alprazolam can be increased when it is combined with 1,10-Phenanthroline.
3,4-DichloroisocoumarinThe serum concentration of Alprazolam can be increased when it is combined with 3,4-Dichloroisocoumarin.
4-(2-AMINOETHYL)BENZENESULFONYL FLUORIDEThe serum concentration of Alprazolam can be increased when it is combined with 4-(2-AMINOETHYL)BENZENESULFONYL FLUORIDE.
7-NitroindazoleThe risk or severity of adverse effects can be increased when Alprazolam is combined with 7-Nitroindazole.
AbirateroneThe metabolism of Alprazolam can be decreased when combined with Abiraterone.
AcepromazineThe risk or severity of adverse effects can be increased when Alprazolam is combined with Acepromazine.
AceprometazineThe risk or severity of adverse effects can be increased when Alprazolam is combined with Aceprometazine.
adipiplonThe risk or severity of adverse effects can be increased when Alprazolam is combined with adipiplon.
AgomelatineThe risk or severity of adverse effects can be increased when Alprazolam is combined with Agomelatine.
AlfaxaloneThe risk or severity of adverse effects can be increased when Alprazolam is combined with Alfaxalone.
AlfentanilThe risk or severity of adverse effects can be increased when Alprazolam is combined with Alfentanil.
AlogliptinThe serum concentration of Alprazolam can be increased when it is combined with Alogliptin.
Alpha-1-proteinase inhibitorThe serum concentration of Alprazolam can be increased when it is combined with Alpha-1-proteinase inhibitor.
AlphacetylmethadolThe risk or severity of adverse effects can be increased when Alprazolam is combined with Alphacetylmethadol.
AminophyllineThe therapeutic efficacy of Alprazolam can be decreased when used in combination with Aminophylline.
AmiodaroneThe metabolism of Alprazolam can be decreased when combined with Amiodarone.
AmisulprideThe risk or severity of adverse effects can be increased when Alprazolam is combined with Amisulpride.
AmitriptylineThe risk or severity of adverse effects can be increased when Alprazolam is combined with Amitriptyline.
AmobarbitalThe risk or severity of adverse effects can be increased when Alprazolam is combined with Amobarbital.
AmoxapineThe risk or severity of adverse effects can be increased when Alprazolam is combined with Amoxapine.
AmperozideThe risk or severity of adverse effects can be increased when Alprazolam is combined with Amperozide.
AmprenavirThe serum concentration of Alprazolam can be increased when it is combined with Amprenavir.
Antithrombin III humanThe serum concentration of Alprazolam can be increased when it is combined with Antithrombin III human.
ApixabanThe serum concentration of Alprazolam can be increased when it is combined with Apixaban.
AprepitantThe serum concentration of Alprazolam can be increased when it is combined with Aprepitant.
AprotininThe serum concentration of Alprazolam can be increased when it is combined with Aprotinin.
ArgatrobanThe serum concentration of Alprazolam can be increased when it is combined with Argatroban.
AripiprazoleThe serum concentration of Aripiprazole can be increased when it is combined with Alprazolam.
AripiprazoleThe risk or severity of adverse effects can be increased when Aripiprazole is combined with Alprazolam.
ArticaineThe risk or severity of adverse effects can be increased when Alprazolam is combined with Articaine.
AsenapineThe risk or severity of adverse effects can be increased when Alprazolam is combined with Asenapine.
AsunaprevirThe serum concentration of Alprazolam can be increased when it is combined with Asunaprevir.
AtazanavirThe serum concentration of Alprazolam can be increased when it is combined with Atazanavir.
AtomoxetineThe metabolism of Alprazolam can be decreased when combined with Atomoxetine.
AzaperoneThe risk or severity of adverse effects can be increased when Alprazolam is combined with Azaperone.
AzelastineAlprazolam may increase the central nervous system depressant (CNS depressant) activities of Azelastine.
AzelastineThe risk or severity of adverse effects can be increased when Azelastine is combined with Alprazolam.
BaclofenThe risk or severity of adverse effects can be increased when Alprazolam is combined with Baclofen.
BarbitalThe risk or severity of adverse effects can be increased when Alprazolam is combined with Barbital.
BatimastatThe serum concentration of Alprazolam can be increased when it is combined with Batimastat.
BenazeprilThe serum concentration of Alprazolam can be increased when it is combined with Benazepril.
BenzamidineThe serum concentration of Alprazolam can be increased when it is combined with Benzamidine.
BenzocaineThe risk or severity of adverse effects can be increased when Alprazolam is combined with Benzocaine.
Benzyl alcoholThe risk or severity of adverse effects can be increased when Alprazolam is combined with Benzyl alcohol.
BexaroteneThe serum concentration of Alprazolam can be decreased when it is combined with Bexarotene.
BivalirudinThe serum concentration of Alprazolam can be increased when it is combined with Bivalirudin.
BoceprevirThe serum concentration of Alprazolam can be increased when it is combined with Boceprevir.
BortezomibThe metabolism of Alprazolam can be decreased when combined with Bortezomib.
BosentanThe serum concentration of Alprazolam can be decreased when it is combined with Bosentan.
BrexpiprazoleThe risk or severity of adverse effects can be increased when Alprazolam is combined with Brexpiprazole.
BrimonidineBrimonidine may increase the central nervous system depressant (CNS depressant) activities of Alprazolam.
BrimonidineThe risk or severity of adverse effects can be increased when Alprazolam is combined with Brimonidine.
BromazepamThe risk or severity of adverse effects can be increased when Alprazolam is combined with Bromazepam.
BrompheniramineThe risk or severity of adverse effects can be increased when Alprazolam is combined with Brompheniramine.
BrotizolamThe risk or severity of adverse effects can be increased when Alprazolam is combined with Brotizolam.
BupivacaineThe risk or severity of adverse effects can be increased when Bupivacaine is combined with Alprazolam.
BuprenorphineThe risk or severity of adverse effects can be increased when Alprazolam is combined with Buprenorphine.
BuspironeThe risk or severity of adverse effects can be increased when Alprazolam is combined with Buspirone.
ButabarbitalThe risk or severity of adverse effects can be increased when Butabarbital is combined with Alprazolam.
ButacaineThe risk or severity of adverse effects can be increased when Alprazolam is combined with Butacaine.
ButalbitalThe risk or severity of adverse effects can be increased when Alprazolam is combined with Butalbital.
ButambenThe risk or severity of adverse effects can be increased when Alprazolam is combined with Butamben.
ButethalThe risk or severity of adverse effects can be increased when Alprazolam is combined with Butethal.
ButorphanolThe risk or severity of adverse effects can be increased when Alprazolam is combined with Butorphanol.
CandoxatrilThe serum concentration of Alprazolam can be increased when it is combined with Candoxatril.
CapecitabineThe metabolism of Alprazolam can be decreased when combined with Capecitabine.
CaptoprilThe serum concentration of Alprazolam can be increased when it is combined with Captopril.
CarbamazepineThe risk or severity of adverse effects can be increased when Alprazolam is combined with Carbamazepine.
CarbinoxamineThe risk or severity of adverse effects can be increased when Alprazolam is combined with Carbinoxamine.
CarfentanilThe risk or severity of adverse effects can be increased when Alprazolam is combined with Carfentanil.
CarisoprodolThe risk or severity of adverse effects can be increased when Alprazolam is combined with Carisoprodol.
CeritinibThe serum concentration of Alprazolam can be increased when it is combined with Ceritinib.
CetirizineThe risk or severity of adverse effects can be increased when Alprazolam is combined with Cetirizine.
Chloral hydrateThe risk or severity of adverse effects can be increased when Alprazolam is combined with Chloral hydrate.
ChlordiazepoxideThe risk or severity of adverse effects can be increased when Alprazolam is combined with Chlordiazepoxide.
ChlormezanoneThe risk or severity of adverse effects can be increased when Alprazolam is combined with Chlormezanone.
ChloroprocaineThe risk or severity of adverse effects can be increased when Alprazolam is combined with Chloroprocaine.
ChlorphenamineThe risk or severity of adverse effects can be increased when Alprazolam is combined with Chlorphenamine.
ChlorpromazineThe risk or severity of adverse effects can be increased when Alprazolam is combined with Chlorpromazine.
ChlorprothixeneThe risk or severity of adverse effects can be increased when Alprazolam is combined with Chlorprothixene.
ChlorzoxazoneThe risk or severity of adverse effects can be increased when Alprazolam is combined with Chlorzoxazone.
CholecalciferolThe metabolism of Alprazolam can be decreased when combined with Cholecalciferol.
ChymostatinThe serum concentration of Alprazolam can be increased when it is combined with Chymostatin.
CilastatinThe serum concentration of Alprazolam can be increased when it is combined with Cilastatin.
CilazaprilThe serum concentration of Alprazolam can be increased when it is combined with Cilazapril.
CinchocaineThe risk or severity of adverse effects can be increased when Alprazolam is combined with Cinchocaine.
CitalopramThe risk or severity of adverse effects can be increased when Alprazolam is combined with Citalopram.
ClarithromycinThe metabolism of Alprazolam can be decreased when combined with Clarithromycin.
ClemastineThe metabolism of Alprazolam can be decreased when combined with Clemastine.
ClemastineThe risk or severity of adverse effects can be increased when Alprazolam is combined with Clemastine.
ClidiniumThe risk or severity of adverse effects can be increased when Alprazolam is combined with Clidinium.
ClobazamThe risk or severity of adverse effects can be increased when Alprazolam is combined with Clobazam.
clomethiazoleThe risk or severity of adverse effects can be increased when Alprazolam is combined with clomethiazole.
ClomipramineThe risk or severity of adverse effects can be increased when Alprazolam is combined with Clomipramine.
ClonazepamThe risk or severity of adverse effects can be increased when Alprazolam is combined with Clonazepam.
ClonidineThe risk or severity of adverse effects can be increased when Alprazolam is combined with Clonidine.
ClorazepateThe risk or severity of adverse effects can be increased when Alprazolam is combined with Clorazepate.
ClotrimazoleThe metabolism of Alprazolam can be decreased when combined with Clotrimazole.
ClozapineThe risk or severity of adverse effects can be increased when Clozapine is combined with Alprazolam.
CobicistatThe metabolism of Alprazolam can be decreased when combined with Cobicistat.
CocaineThe risk or severity of adverse effects can be increased when Alprazolam is combined with Cocaine.
CodeineThe risk or severity of adverse effects can be increased when Codeine is combined with Alprazolam.
ConivaptanThe serum concentration of Alprazolam can be increased when it is combined with Conivaptan.
CrizotinibThe metabolism of Alprazolam can be decreased when combined with Crizotinib.
CyclizineThe risk or severity of adverse effects can be increased when Alprazolam is combined with Cyclizine.
CyclobenzaprineThe risk or severity of adverse effects can be increased when Alprazolam is combined with Cyclobenzaprine.
CyclosporineThe metabolism of Alprazolam can be decreased when combined with Cyclosporine.
CyproheptadineThe risk or severity of adverse effects can be increased when Alprazolam is combined with Cyproheptadine.
Dabigatran etexilateThe serum concentration of Alprazolam can be increased when it is combined with Dabigatran etexilate.
DabrafenibThe serum concentration of Alprazolam can be decreased when it is combined with Dabrafenib.
DantroleneThe risk or severity of adverse effects can be increased when Alprazolam is combined with Dantrolene.
DapiprazoleThe risk or severity of adverse effects can be increased when Dapiprazole is combined with Alprazolam.
DapoxetineThe risk or severity of adverse effects can be increased when Alprazolam is combined with Dapoxetine.
DarunavirThe serum concentration of Alprazolam can be increased when it is combined with Darunavir.
DasatinibThe serum concentration of Alprazolam can be increased when it is combined with Dasatinib.
DeferasiroxThe serum concentration of Alprazolam can be decreased when it is combined with Deferasirox.
DelavirdineThe metabolism of Alprazolam can be decreased when combined with Delavirdine.
deramciclaneThe risk or severity of adverse effects can be increased when Alprazolam is combined with deramciclane.
DesfluraneThe risk or severity of adverse effects can be increased when Alprazolam is combined with Desflurane.
DesipramineThe risk or severity of adverse effects can be increased when Alprazolam is combined with Desipramine.
DesloratadineThe risk or severity of adverse effects can be increased when Alprazolam is combined with Desloratadine.
DetomidineThe risk or severity of adverse effects can be increased when Alprazolam is combined with Detomidine.
DexamethasoneThe serum concentration of Alprazolam can be decreased when it is combined with Dexamethasone.
DexbrompheniramineThe risk or severity of adverse effects can be increased when Alprazolam is combined with Dexbrompheniramine.
DexmedetomidineThe risk or severity of adverse effects can be increased when Alprazolam is combined with Dexmedetomidine.
DextromoramideThe risk or severity of adverse effects can be increased when Alprazolam is combined with Dextromoramide.
DextropropoxypheneThe risk or severity of adverse effects can be increased when Alprazolam is combined with Dextropropoxyphene.
DezocineThe risk or severity of adverse effects can be increased when Alprazolam is combined with Dezocine.
DiazepamThe risk or severity of adverse effects can be increased when Alprazolam is combined with Diazepam.
DifenoxinThe risk or severity of adverse effects can be increased when Alprazolam is combined with Difenoxin.
DihydrocodeineThe risk or severity of adverse effects can be increased when Alprazolam is combined with Dihydrocodeine.
DihydroergotamineThe metabolism of Alprazolam can be decreased when combined with Dihydroergotamine.
DihydroetorphineThe risk or severity of adverse effects can be increased when Alprazolam is combined with Dihydroetorphine.
DihydromorphineThe risk or severity of adverse effects can be increased when Alprazolam is combined with Dihydromorphine.
DiltiazemThe metabolism of Alprazolam can be decreased when combined with Diltiazem.
DimenhydrinateThe risk or severity of adverse effects can be increased when Alprazolam is combined with Dimenhydrinate.
DiphenhydramineThe risk or severity of adverse effects can be increased when Alprazolam is combined with Diphenhydramine.
DiphenoxylateThe risk or severity of adverse effects can be increased when Alprazolam is combined with Diphenoxylate.
DofetilideThe serum concentration of Dofetilide can be increased when it is combined with Alprazolam.
DoramectinThe risk or severity of adverse effects can be increased when Alprazolam is combined with Doramectin.
DoxepinThe risk or severity of adverse effects can be increased when Alprazolam is combined with Doxepin.
DoxycyclineThe metabolism of Alprazolam can be decreased when combined with Doxycycline.
DoxylamineDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Alprazolam.
DoxylamineThe risk or severity of adverse effects can be increased when Alprazolam is combined with Doxylamine.
DPDPEThe risk or severity of adverse effects can be increased when Alprazolam is combined with DPDPE.
DronabinolDronabinol may increase the central nervous system depressant (CNS depressant) activities of Alprazolam.
DronedaroneThe metabolism of Alprazolam can be decreased when combined with Dronedarone.
DroperidolThe risk or severity of adverse effects can be increased when Alprazolam is combined with Droperidol.
DrotebanolThe risk or severity of adverse effects can be increased when Alprazolam is combined with Drotebanol.
DyclonineThe risk or severity of adverse effects can be increased when Alprazolam is combined with Dyclonine.
DyphyllineThe therapeutic efficacy of Alprazolam can be decreased when used in combination with Dyphylline.
EcabetThe serum concentration of Alprazolam can be increased when it is combined with Ecabet.
EcgonineThe risk or severity of adverse effects can be increased when Alprazolam is combined with Ecgonine.
ECGONINE METHYL ESTERThe risk or severity of adverse effects can be increased when Alprazolam is combined with ECGONINE METHYL ESTER.
EdoxabanThe serum concentration of Alprazolam can be increased when it is combined with Edoxaban.
EfavirenzThe serum concentration of Alprazolam can be decreased when it is combined with Efavirenz.
EfavirenzThe risk or severity of adverse effects can be increased when Alprazolam is combined with Efavirenz.
ElafinThe serum concentration of Alprazolam can be increased when it is combined with Elafin.
EnalaprilThe serum concentration of Alprazolam can be increased when it is combined with Enalapril.
EnalaprilatThe serum concentration of Alprazolam can be increased when it is combined with Enalaprilat.
EnalkirenThe serum concentration of Alprazolam can be increased when it is combined with Enalkiren.
EnfluraneThe risk or severity of adverse effects can be increased when Enflurane is combined with Alprazolam.
EntacaponeThe risk or severity of adverse effects can be increased when Alprazolam is combined with Entacapone.
EnzalutamideThe serum concentration of Alprazolam can be decreased when it is combined with Enzalutamide.
ErythromycinThe metabolism of Alprazolam can be decreased when combined with Erythromycin.
EscitalopramThe risk or severity of adverse effects can be increased when Alprazolam is combined with Escitalopram.
Eslicarbazepine acetateThe serum concentration of Alprazolam can be decreased when it is combined with Eslicarbazepine acetate.
EstazolamThe risk or severity of adverse effects can be increased when Alprazolam is combined with Estazolam.
EszopicloneThe risk or severity of adverse effects can be increased when Eszopiclone is combined with Alprazolam.
EthanolAlprazolam may increase the central nervous system depressant (CNS depressant) activities of Ethanol.
EthanolThe risk or severity of adverse effects can be increased when Ethanol is combined with Alprazolam.
EthchlorvynolThe risk or severity of adverse effects can be increased when Ethchlorvynol is combined with Alprazolam.
EthosuximideThe risk or severity of adverse effects can be increased when Alprazolam is combined with Ethosuximide.
EthotoinThe risk or severity of adverse effects can be increased when Alprazolam is combined with Ethotoin.
Ethyl carbamateThe risk or severity of adverse effects can be increased when Alprazolam is combined with Ethyl carbamate.
Ethyl loflazepateThe risk or severity of adverse effects can be increased when Alprazolam is combined with Ethyl loflazepate.
EthylmorphineThe risk or severity of adverse effects can be increased when Alprazolam is combined with Ethylmorphine.
EtidocaineThe risk or severity of adverse effects can be increased when Alprazolam is combined with Etidocaine.
EtifoxineThe risk or severity of adverse effects can be increased when Alprazolam is combined with Etifoxine.
EtizolamThe risk or severity of adverse effects can be increased when Alprazolam is combined with Etizolam.
EtomidateThe risk or severity of adverse effects can be increased when Etomidate is combined with Alprazolam.
EtoperidoneThe risk or severity of adverse effects can be increased when Alprazolam is combined with Etoperidone.
EtorphineThe risk or severity of adverse effects can be increased when Alprazolam is combined with Etorphine.
EtravirineThe serum concentration of Alprazolam can be decreased when it is combined with Etravirine.
EzogabineThe risk or severity of adverse effects can be increased when Alprazolam is combined with Ezogabine.
FelbamateThe risk or severity of adverse effects can be increased when Alprazolam is combined with Felbamate.
FencamfamineThe risk or severity of adverse effects can be increased when Alprazolam is combined with Fencamfamine.
FenfluramineThe risk or severity of adverse effects can be increased when Alprazolam is combined with Fenfluramine.
FentanylThe risk or severity of adverse effects can be increased when Alprazolam is combined with Fentanyl.
FexofenadineThe risk or severity of adverse effects can be increased when Alprazolam is combined with Fexofenadine.
FlibanserinThe serum concentration of Flibanserin can be increased when it is combined with Alprazolam.
FlibanserinThe risk or severity of adverse effects can be increased when Flibanserin is combined with Alprazolam.
FloxuridineThe metabolism of Alprazolam can be decreased when combined with Floxuridine.
FluconazoleThe metabolism of Alprazolam can be decreased when combined with Fluconazole.
FludiazepamThe risk or severity of adverse effects can be increased when Alprazolam is combined with Fludiazepam.
FlunarizineThe risk or severity of adverse effects can be increased when Alprazolam is combined with Flunarizine.
FlunitrazepamThe risk or severity of adverse effects can be increased when Alprazolam is combined with Flunitrazepam.
FluorouracilThe metabolism of Alprazolam can be decreased when combined with Fluorouracil.
FluoxetineThe risk or severity of adverse effects can be increased when Alprazolam is combined with Fluoxetine.
FlupentixolThe risk or severity of adverse effects can be increased when Alprazolam is combined with Flupentixol.
FluphenazineThe risk or severity of adverse effects can be increased when Alprazolam is combined with Fluphenazine.
FlurazepamThe risk or severity of adverse effects can be increased when Alprazolam is combined with Flurazepam.
FluspirileneThe risk or severity of adverse effects can be increased when Alprazolam is combined with Fluspirilene.
Fluticasone PropionateThe risk or severity of adverse effects can be increased when Alprazolam is combined with Fluticasone Propionate.
FluvastatinThe metabolism of Alprazolam can be decreased when combined with Fluvastatin.
FluvoxamineThe serum concentration of Alprazolam can be increased when it is combined with Fluvoxamine.
FluvoxamineThe risk or severity of adverse effects can be increased when Alprazolam is combined with Fluvoxamine.
FosamprenavirThe metabolism of Alprazolam can be decreased when combined with Fosamprenavir.
FosaprepitantThe serum concentration of Alprazolam can be increased when it is combined with Fosaprepitant.
FosinoprilThe serum concentration of Alprazolam can be increased when it is combined with Fosinopril.
FosphenytoinThe serum concentration of Fosphenytoin can be increased when it is combined with Alprazolam.
FosphenytoinThe risk or severity of adverse effects can be increased when Fosphenytoin is combined with Alprazolam.
FospropofolThe risk or severity of adverse effects can be increased when Alprazolam is combined with Fospropofol.
Fusidic AcidThe serum concentration of Alprazolam can be increased when it is combined with Fusidic Acid.
GabapentinThe risk or severity of adverse effects can be increased when Alprazolam is combined with Gabapentin.
gabapentin enacarbilThe risk or severity of adverse effects can be increased when Alprazolam is combined with gabapentin enacarbil.
Gamma Hydroxybutyric AcidThe risk or severity of adverse effects can be increased when Alprazolam is combined with Gamma Hydroxybutyric Acid.
GeldanamycinThe serum concentration of Alprazolam can be increased when it is combined with Geldanamycin.
GemfibrozilThe metabolism of Alprazolam can be decreased when combined with Gemfibrozil.
GlutethimideThe risk or severity of adverse effects can be increased when Alprazolam is combined with Glutethimide.
GM6001The serum concentration of Alprazolam can be increased when it is combined with GM6001.
GuanfacineThe risk or severity of adverse effects can be increased when Alprazolam is combined with Guanfacine.
HalazepamThe risk or severity of adverse effects can be increased when Alprazolam is combined with Halazepam.
HaloperidolThe risk or severity of adverse effects can be increased when Alprazolam is combined with Haloperidol.
HalothaneThe risk or severity of adverse effects can be increased when Alprazolam is combined with Halothane.
HeroinThe risk or severity of adverse effects can be increased when Alprazolam is combined with Heroin.
HexobarbitalThe risk or severity of adverse effects can be increased when Alprazolam is combined with Hexobarbital.
HirulogThe serum concentration of Alprazolam can be increased when it is combined with Hirulog.
HydrocodoneThe serum concentration of Hydrocodone can be increased when it is combined with Alprazolam.
HydrocodoneThe risk or severity of adverse effects can be increased when Hydrocodone is combined with Alprazolam.
HydromorphoneThe risk or severity of adverse effects can be increased when Hydromorphone is combined with Alprazolam.
HydroxyzineHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Alprazolam.
HydroxyzineThe risk or severity of adverse effects can be increased when Alprazolam is combined with Hydroxyzine.
IdelalisibThe serum concentration of Alprazolam can be increased when it is combined with Idelalisib.
IloperidoneThe risk or severity of adverse effects can be increased when Alprazolam is combined with Iloperidone.
ImatinibThe metabolism of Alprazolam can be decreased when combined with Imatinib.
ImipramineThe risk or severity of adverse effects can be increased when Alprazolam is combined with Imipramine.
IndalpineThe risk or severity of adverse effects can be increased when Alprazolam is combined with Indalpine.
IndinavirThe serum concentration of Alprazolam can be increased when it is combined with Indinavir.
IrbesartanThe metabolism of Alprazolam can be decreased when combined with Irbesartan.
IsavuconazoniumThe metabolism of Alprazolam can be decreased when combined with Isavuconazonium.
IsofluraneThe risk or severity of adverse effects can be increased when Alprazolam is combined with Isoflurane.
IsoflurophateThe serum concentration of Alprazolam can be increased when it is combined with Isoflurophate.
IsradipineThe metabolism of Alprazolam can be decreased when combined with Isradipine.
ItraconazoleThe serum concentration of Alprazolam can be increased when it is combined with Itraconazole.
IvacaftorThe serum concentration of Alprazolam can be increased when it is combined with Ivacaftor.
IxazomibThe serum concentration of Alprazolam can be increased when it is combined with Ixazomib.
KetamineThe risk or severity of adverse effects can be increased when Alprazolam is combined with Ketamine.
KetazolamThe risk or severity of adverse effects can be increased when Alprazolam is combined with Ketazolam.
KetobemidoneThe risk or severity of adverse effects can be increased when Alprazolam is combined with Ketobemidone.
KetoconazoleThe serum concentration of Alprazolam can be increased when it is combined with Ketoconazole.
LamotrigineThe risk or severity of adverse effects can be increased when Alprazolam is combined with Lamotrigine.
LeflunomideThe metabolism of Alprazolam can be decreased when combined with Leflunomide.
LepirudinThe serum concentration of Alprazolam can be increased when it is combined with Lepirudin.
LevetiracetamThe risk or severity of adverse effects can be increased when Alprazolam is combined with Levetiracetam.
LevobupivacaineThe risk or severity of adverse effects can be increased when Alprazolam is combined with Levobupivacaine.
LevocabastineThe risk or severity of adverse effects can be increased when Alprazolam is combined with Levocabastine.
LevocetirizineThe risk or severity of adverse effects can be increased when Alprazolam is combined with Levocetirizine.
LevodopaThe risk or severity of adverse effects can be increased when Alprazolam is combined with Levodopa.
Levomethadyl AcetateThe risk or severity of adverse effects can be increased when Alprazolam is combined with Levomethadyl Acetate.
LevomilnacipranThe risk or severity of adverse effects can be increased when Alprazolam is combined with Levomilnacipran.
LevorphanolThe risk or severity of adverse effects can be increased when Alprazolam is combined with Levorphanol.
LidocaineThe risk or severity of adverse effects can be increased when Lidocaine is combined with Alprazolam.
LinagliptinThe serum concentration of Alprazolam can be increased when it is combined with Linagliptin.
LisinoprilThe serum concentration of Alprazolam can be increased when it is combined with Lisinopril.
LithiumThe risk or severity of adverse effects can be increased when Alprazolam is combined with Lithium.
LofentanilThe risk or severity of adverse effects can be increased when Alprazolam is combined with Lofentanil.
LomitapideThe serum concentration of Lomitapide can be increased when it is combined with Alprazolam.
LopinavirThe serum concentration of Alprazolam can be increased when it is combined with Lopinavir.
LoratadineThe risk or severity of adverse effects can be increased when Alprazolam is combined with Loratadine.
LorazepamThe risk or severity of adverse effects can be increased when Lorazepam is combined with Alprazolam.
LosartanThe metabolism of Alprazolam can be decreased when combined with Losartan.
LovastatinThe metabolism of Alprazolam can be decreased when combined with Lovastatin.
LoxapineThe risk or severity of adverse effects can be increased when Alprazolam is combined with Loxapine.
Lu AA21004The risk or severity of adverse effects can be increased when Alprazolam is combined with Lu AA21004.
LuliconazoleThe serum concentration of Alprazolam can be increased when it is combined with Luliconazole.
LumacaftorThe serum concentration of Alprazolam can be decreased when it is combined with Lumacaftor.
LurasidoneThe risk or severity of adverse effects can be increased when Alprazolam is combined with Lurasidone.
Magnesium SulfateMagnesium Sulfate may increase the central nervous system depressant (CNS depressant) activities of Alprazolam.
Magnesium SulfateThe risk or severity of adverse effects can be increased when Alprazolam is combined with Magnesium Sulfate.
MaprotilineThe risk or severity of adverse effects can be increased when Alprazolam is combined with Maprotiline.
MeclizineThe risk or severity of adverse effects can be increased when Alprazolam is combined with Meclizine.
MedetomidineThe risk or severity of adverse effects can be increased when Alprazolam is combined with Medetomidine.
MelatoninThe risk or severity of adverse effects can be increased when Alprazolam is combined with Melatonin.
MelperoneThe risk or severity of adverse effects can be increased when Alprazolam is combined with Melperone.
MepivacaineThe risk or severity of adverse effects can be increased when Alprazolam is combined with Mepivacaine.
MeprobamateThe risk or severity of adverse effects can be increased when Meprobamate is combined with Alprazolam.
MesoridazineThe risk or severity of adverse effects can be increased when Alprazolam is combined with Mesoridazine.
MetaxaloneThe risk or severity of adverse effects can be increased when Alprazolam is combined with Metaxalone.
MethadoneAlprazolam may increase the central nervous system depressant (CNS depressant) activities of Methadone.
MethadoneThe risk or severity of adverse effects can be increased when Methadone is combined with Alprazolam.
Methadyl AcetateThe risk or severity of adverse effects can be increased when Alprazolam is combined with Methadyl Acetate.
MethapyrileneThe risk or severity of adverse effects can be increased when Alprazolam is combined with Methapyrilene.
MethaqualoneThe risk or severity of adverse effects can be increased when Alprazolam is combined with Methaqualone.
MethocarbamolThe risk or severity of adverse effects can be increased when Alprazolam is combined with Methocarbamol.
MethohexitalThe risk or severity of adverse effects can be increased when Alprazolam is combined with Methohexital.
MethotrimeprazineThe risk or severity of adverse effects can be increased when Alprazolam is combined with Methotrimeprazine.
MethoxyfluraneThe risk or severity of adverse effects can be increased when Alprazolam is combined with Methoxyflurane.
MethsuximideThe risk or severity of adverse effects can be increased when Alprazolam is combined with Methsuximide.
MethylphenobarbitalThe risk or severity of adverse effects can be increased when Alprazolam is combined with Methylphenobarbital.
MetyrosineAlprazolam may increase the sedative activities of Metyrosine.
MidazolamThe risk or severity of adverse effects can be increased when Alprazolam is combined with Midazolam.
MifepristoneThe metabolism of Alprazolam can be decreased when combined with Mifepristone.
MilnacipranThe risk or severity of adverse effects can be increased when Alprazolam is combined with Milnacipran.
MinocyclineMinocycline may increase the central nervous system depressant (CNS depressant) activities of Alprazolam.
MirtazapineAlprazolam may increase the central nervous system depressant (CNS depressant) activities of Mirtazapine.
MirtazapineThe risk or severity of adverse effects can be increased when Mirtazapine is combined with Alprazolam.
MitotaneThe serum concentration of Alprazolam can be decreased when it is combined with Mitotane.
ModafinilThe serum concentration of Alprazolam can be decreased when it is combined with Modafinil.
MoexiprilThe serum concentration of Alprazolam can be increased when it is combined with Moexipril.
MolindoneThe risk or severity of adverse effects can be increased when Alprazolam is combined with Molindone.
MorphineThe risk or severity of adverse effects can be increased when Morphine is combined with Alprazolam.
N-(3-Propylcarbamoyloxirane-2-Carbonyl)-Isoleucyl-ProlineThe serum concentration of Alprazolam can be increased when it is combined with N-(3-Propylcarbamoyloxirane-2-Carbonyl)-Isoleucyl-Proline.
NabiloneNabilone may increase the central nervous system depressant (CNS depressant) activities of Alprazolam.
NabiloneThe risk or severity of adverse effects can be increased when Alprazolam is combined with Nabilone.
NafcillinThe serum concentration of Alprazolam can be decreased when it is combined with Nafcillin.
NalbuphineThe risk or severity of adverse effects can be increased when Alprazolam is combined with Nalbuphine.
NCX 4016The serum concentration of Alprazolam can be increased when it is combined with NCX 4016.
NefazodoneThe metabolism of Alprazolam can be decreased when combined with Nefazodone.
NelfinavirThe serum concentration of Alprazolam can be increased when it is combined with Nelfinavir.
NetupitantThe serum concentration of Alprazolam can be increased when it is combined with Netupitant.
NevirapineThe metabolism of Alprazolam can be decreased when combined with Nevirapine.
NicardipineThe metabolism of Alprazolam can be decreased when combined with Nicardipine.
NilotinibThe metabolism of Alprazolam can be decreased when combined with Nilotinib.
NimodipineThe serum concentration of Nimodipine can be increased when it is combined with Alprazolam.
NitrazepamThe risk or severity of adverse effects can be increased when Alprazolam is combined with Nitrazepam.
Nitrous oxideThe risk or severity of adverse effects can be increased when Alprazolam is combined with Nitrous oxide.
NormethadoneThe risk or severity of adverse effects can be increased when Alprazolam is combined with Normethadone.
NortriptylineThe risk or severity of adverse effects can be increased when Alprazolam is combined with Nortriptyline.
OlanzapineThe risk or severity of adverse effects can be increased when Olanzapine is combined with Alprazolam.
OlaparibThe metabolism of Alprazolam can be decreased when combined with Olaparib.
OlopatadineThe risk or severity of adverse effects can be increased when Alprazolam is combined with Olopatadine.
OmapatrilatThe serum concentration of Alprazolam can be increased when it is combined with Omapatrilat.
OmeprazoleThe metabolism of Alprazolam can be decreased when combined with Omeprazole.
OndansetronThe risk or severity of adverse effects can be increased when Alprazolam is combined with Ondansetron.
OpiumThe risk or severity of adverse effects can be increased when Alprazolam is combined with Opium.
OrphenadrineAlprazolam may increase the central nervous system depressant (CNS depressant) activities of Orphenadrine.
OrphenadrineThe risk or severity of adverse effects can be increased when Orphenadrine is combined with Alprazolam.
OsanetantThe risk or severity of adverse effects can be increased when Alprazolam is combined with Osanetant.
OsimertinibThe serum concentration of Alprazolam can be increased when it is combined with Osimertinib.
OtamixabanThe serum concentration of Alprazolam can be increased when it is combined with Otamixaban.
OxazepamThe risk or severity of adverse effects can be increased when Alprazolam is combined with Oxazepam.
OxprenololThe risk or severity of adverse effects can be increased when Alprazolam is combined with Oxprenolol.
OxybuprocaineThe risk or severity of adverse effects can be increased when Alprazolam is combined with Oxybuprocaine.
OxycodoneThe risk or severity of adverse effects can be increased when Alprazolam is combined with Oxycodone.
OxymorphoneThe risk or severity of adverse effects can be increased when Alprazolam is combined with Oxymorphone.
PalbociclibThe serum concentration of Alprazolam can be increased when it is combined with Palbociclib.
PaliperidoneThe risk or severity of adverse effects can be increased when Alprazolam is combined with Paliperidone.
ParaldehydeAlprazolam may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.
ParaldehydeThe risk or severity of adverse effects can be increased when Paraldehyde is combined with Alprazolam.
ParoxetineThe risk or severity of adverse effects can be increased when Alprazolam is combined with Paroxetine.
PentazocineThe risk or severity of adverse effects can be increased when Alprazolam is combined with Pentazocine.
PentobarbitalThe risk or severity of adverse effects can be increased when Pentobarbital is combined with Alprazolam.
PerampanelThe risk or severity of adverse effects can be increased when Alprazolam is combined with Perampanel.
PerindoprilThe serum concentration of Alprazolam can be increased when it is combined with Perindopril.
PerospironeThe risk or severity of adverse effects can be increased when Alprazolam is combined with Perospirone.
PerphenazineThe risk or severity of adverse effects can be increased when Alprazolam is combined with Perphenazine.
PethidineThe risk or severity of adverse effects can be increased when Alprazolam is combined with Pethidine.
PhenobarbitalThe risk or severity of adverse effects can be increased when Alprazolam is combined with Phenobarbital.
PhenoxyethanolThe risk or severity of adverse effects can be increased when Alprazolam is combined with Phenoxyethanol.
PhenytoinThe serum concentration of Phenytoin can be increased when it is combined with Alprazolam.
PhenytoinThe risk or severity of adverse effects can be increased when Phenytoin is combined with Alprazolam.
PhosphoramidonThe serum concentration of Alprazolam can be increased when it is combined with Phosphoramidon.
PimozideThe serum concentration of Pimozide can be increased when it is combined with Alprazolam.
PimozideThe risk or severity of adverse effects can be increased when Pimozide is combined with Alprazolam.
PipamperoneThe risk or severity of adverse effects can be increased when Alprazolam is combined with Pipamperone.
PipotiazineThe risk or severity of adverse effects can be increased when Alprazolam is combined with Pipotiazine.
PizotifenThe risk or severity of adverse effects can be increased when Alprazolam is combined with Pizotifen.
PomalidomideThe risk or severity of adverse effects can be increased when Alprazolam is combined with Pomalidomide.
PosaconazoleThe metabolism of Alprazolam can be decreased when combined with Posaconazole.
PramipexoleAlprazolam may increase the sedative activities of Pramipexole.
PramocaineThe risk or severity of adverse effects can be increased when Alprazolam is combined with Pramocaine.
PrazepamThe risk or severity of adverse effects can be increased when Alprazolam is combined with Prazepam.
PregabalinThe risk or severity of adverse effects can be increased when Pregabalin is combined with Alprazolam.
PrilocaineThe risk or severity of adverse effects can be increased when Alprazolam is combined with Prilocaine.
PrimidoneThe risk or severity of adverse effects can be increased when Alprazolam is combined with Primidone.
PrinomastatThe serum concentration of Alprazolam can be increased when it is combined with Prinomastat.
ProcaineThe risk or severity of adverse effects can be increased when Alprazolam is combined with Procaine.
ProchlorperazineThe risk or severity of adverse effects can be increased when Alprazolam is combined with Prochlorperazine.
PromazineThe risk or severity of adverse effects can be increased when Alprazolam is combined with Promazine.
PromethazineThe risk or severity of adverse effects can be increased when Alprazolam is combined with Promethazine.
ProparacaineThe risk or severity of adverse effects can be increased when Alprazolam is combined with Proparacaine.
PropofolThe risk or severity of adverse effects can be increased when Alprazolam is combined with Propofol.
PropoxycaineThe risk or severity of adverse effects can be increased when Alprazolam is combined with Propoxycaine.
ProtriptylineThe risk or severity of adverse effects can be increased when Alprazolam is combined with Protriptyline.
PSD502The risk or severity of adverse effects can be increased when Alprazolam is combined with PSD502.
PyrimethamineThe metabolism of Alprazolam can be decreased when combined with Pyrimethamine.
QuazepamThe risk or severity of adverse effects can be increased when Alprazolam is combined with Quazepam.
QuetiapineThe risk or severity of adverse effects can be increased when Alprazolam is combined with Quetiapine.
QuinaprilThe serum concentration of Alprazolam can be increased when it is combined with Quinapril.
QuinineThe metabolism of Alprazolam can be decreased when combined with Quinine.
RamelteonThe risk or severity of adverse effects can be increased when Alprazolam is combined with Ramelteon.
RamiprilThe serum concentration of Alprazolam can be increased when it is combined with Ramipril.
RanolazineThe metabolism of Alprazolam can be decreased when combined with Ranolazine.
RemifentanilThe risk or severity of adverse effects can be increased when Alprazolam is combined with Remifentanil.
RemikirenThe serum concentration of Alprazolam can be increased when it is combined with Remikiren.
RemoxiprideThe risk or severity of adverse effects can be increased when Alprazolam is combined with Remoxipride.
ReserpineThe risk or severity of adverse effects can be increased when Reserpine is combined with Alprazolam.
RifabutinThe metabolism of Alprazolam can be increased when combined with Rifabutin.
RifampicinThe metabolism of Alprazolam can be increased when combined with Rifampicin.
RifapentineThe metabolism of Alprazolam can be increased when combined with Rifapentine.
RisperidoneThe risk or severity of adverse effects can be increased when Alprazolam is combined with Risperidone.
RitonavirThe serum concentration of Alprazolam can be increased when it is combined with Ritonavir.
RivaroxabanThe serum concentration of Alprazolam can be increased when it is combined with Rivaroxaban.
RomifidineThe risk or severity of adverse effects can be increased when Alprazolam is combined with Romifidine.
RopiniroleAlprazolam may increase the sedative activities of Ropinirole.
RopivacaineThe risk or severity of adverse effects can be increased when Ropivacaine is combined with Alprazolam.
RotigotineAlprazolam may increase the sedative activities of Rotigotine.
RufinamideThe risk or severity of adverse effects can be increased when Rufinamide is combined with Alprazolam.
S-EthylisothioureaThe risk or severity of adverse effects can be increased when Alprazolam is combined with S-Ethylisothiourea.
SaquinavirThe serum concentration of Alprazolam can be increased when it is combined with Saquinavir.
SaxagliptinThe serum concentration of Alprazolam can be increased when it is combined with Saxagliptin.
ScopolamineThe risk or severity of adverse effects can be increased when Alprazolam is combined with Scopolamine.
SecobarbitalThe risk or severity of adverse effects can be increased when Alprazolam is combined with Secobarbital.
SertindoleThe risk or severity of adverse effects can be increased when Alprazolam is combined with Sertindole.
SertralineThe risk or severity of adverse effects can be increased when Alprazolam is combined with Sertraline.
SevofluraneThe risk or severity of adverse effects can be increased when Alprazolam is combined with Sevoflurane.
SildenafilThe metabolism of Alprazolam can be decreased when combined with Sildenafil.
SiltuximabThe serum concentration of Alprazolam can be decreased when it is combined with Siltuximab.
SimeprevirThe serum concentration of Alprazolam can be increased when it is combined with Simeprevir.
SitagliptinThe serum concentration of Alprazolam can be increased when it is combined with Sitagliptin.
Sodium oxybateAlprazolam may increase the central nervous system depressant (CNS depressant) activities of Sodium oxybate.
Sodium oxybateThe risk or severity of adverse effects can be increased when Sodium oxybate is combined with Alprazolam.
SorafenibThe metabolism of Alprazolam can be decreased when combined with Sorafenib.
SpiraprilThe serum concentration of Alprazolam can be increased when it is combined with Spirapril.
St. John's WortThe serum concentration of Alprazolam can be decreased when it is combined with St. John's Wort.
StiripentolThe risk or severity of adverse effects can be increased when Alprazolam is combined with Stiripentol.
SufentanilThe risk or severity of adverse effects can be increased when Alprazolam is combined with Sufentanil.
SulfadiazineThe metabolism of Alprazolam can be decreased when combined with Sulfadiazine.
SulfamethoxazoleThe metabolism of Alprazolam can be decreased when combined with Sulfamethoxazole.
SulfisoxazoleThe metabolism of Alprazolam can be decreased when combined with Sulfisoxazole.
SulpirideThe risk or severity of adverse effects can be increased when Sulpiride is combined with Alprazolam.
SuvorexantThe risk or severity of adverse effects can be increased when Alprazolam is combined with Suvorexant.
TapentadolThe risk or severity of adverse effects can be increased when Alprazolam is combined with Tapentadol.
TasimelteonThe risk or severity of adverse effects can be increased when Alprazolam is combined with Tasimelteon.
TeduglutideThe serum concentration of Alprazolam can be increased when it is combined with Teduglutide.
TelaprevirThe serum concentration of Alprazolam can be increased when it is combined with Telaprevir.
TelithromycinThe metabolism of Alprazolam can be decreased when combined with Telithromycin.
TemazepamThe risk or severity of adverse effects can be increased when Temazepam is combined with Alprazolam.
TemocaprilThe serum concentration of Alprazolam can be increased when it is combined with Temocapril.
TetrabenazineThe risk or severity of adverse effects can be increased when Alprazolam is combined with Tetrabenazine.
TetracaineThe risk or severity of adverse effects can be increased when Alprazolam is combined with Tetracaine.
TetrodotoxinThe risk or severity of adverse effects can be increased when Alprazolam is combined with Tetrodotoxin.
ThalidomideAlprazolam may increase the central nervous system depressant (CNS depressant) activities of Thalidomide.
ThalidomideThe risk or severity of adverse effects can be increased when Thalidomide is combined with Alprazolam.
TheophyllineThe therapeutic efficacy of Alprazolam can be decreased when used in combination with Theophylline.
ThiamylalThe risk or severity of adverse effects can be increased when Alprazolam is combined with Thiamylal.
ThiopentalThe risk or severity of adverse effects can be increased when Alprazolam is combined with Thiopental.
ThioridazineThe risk or severity of adverse effects can be increased when Alprazolam is combined with Thioridazine.
ThiorphanThe serum concentration of Alprazolam can be increased when it is combined with Thiorphan.
ThiothixeneThe risk or severity of adverse effects can be increased when Alprazolam is combined with Thiothixene.
TiagabineThe risk or severity of adverse effects can be increased when Alprazolam is combined with Tiagabine.
TicagrelorThe metabolism of Alprazolam can be decreased when combined with Ticagrelor.
TiclopidineThe metabolism of Alprazolam can be decreased when combined with Ticlopidine.
TiletamineThe risk or severity of adverse effects can be increased when Alprazolam is combined with Tiletamine.
TipranavirThe serum concentration of Alprazolam can be increased when it is combined with Tipranavir.
TizanidineThe risk or severity of adverse effects can be increased when Alprazolam is combined with Tizanidine.
TocilizumabThe serum concentration of Alprazolam can be decreased when it is combined with Tocilizumab.
TolbutamideThe metabolism of Alprazolam can be decreased when combined with Tolbutamide.
TolcaponeThe risk or severity of adverse effects can be increased when Alprazolam is combined with Tolcapone.
TopiramateThe risk or severity of adverse effects can be increased when Alprazolam is combined with Topiramate.
TramadolThe risk or severity of adverse effects can be increased when Tramadol is combined with Alprazolam.
TrandolaprilThe serum concentration of Alprazolam can be increased when it is combined with Trandolapril.
Trans-2-PhenylcyclopropylamineThe risk or severity of adverse effects can be increased when Alprazolam is combined with Trans-2-Phenylcyclopropylamine.
TranylcypromineThe risk or severity of adverse effects can be increased when Alprazolam is combined with Tranylcypromine.
TrazodoneThe risk or severity of adverse effects can be increased when Alprazolam is combined with Trazodone.
TriazolamThe risk or severity of adverse effects can be increased when Alprazolam is combined with Triazolam.
TrifluoperazineThe risk or severity of adverse effects can be increased when Alprazolam is combined with Trifluoperazine.
TriflupromazineThe risk or severity of adverse effects can be increased when Alprazolam is combined with Triflupromazine.
TrimethoprimThe metabolism of Alprazolam can be decreased when combined with Trimethoprim.
TrimipramineThe risk or severity of adverse effects can be increased when Alprazolam is combined with Trimipramine.
TriprolidineThe risk or severity of adverse effects can be increased when Alprazolam is combined with Triprolidine.
UbenimexThe serum concentration of Alprazolam can be increased when it is combined with Ubenimex.
Valproic AcidThe risk or severity of adverse effects can be increased when Valproic Acid is combined with Alprazolam.
ValsartanThe metabolism of Alprazolam can be decreased when combined with Valsartan.
VenlafaxineThe metabolism of Alprazolam can be decreased when combined with Venlafaxine.
VerapamilThe metabolism of Alprazolam can be decreased when combined with Verapamil.
VigabatrinThe risk or severity of adverse effects can be increased when Alprazolam is combined with Vigabatrin.
VilazodoneThe risk or severity of adverse effects can be increased when Alprazolam is combined with Vilazodone.
VildagliptinThe serum concentration of Alprazolam can be increased when it is combined with Vildagliptin.
VoriconazoleThe metabolism of Alprazolam can be decreased when combined with Voriconazole.
VortioxetineThe risk or severity of adverse effects can be increased when Alprazolam is combined with Vortioxetine.
XimelagatranThe serum concentration of Alprazolam can be increased when it is combined with Ximelagatran.
XylazineThe risk or severity of adverse effects can be increased when Alprazolam is combined with Xylazine.
YohimbineThe therapeutic efficacy of Alprazolam can be decreased when used in combination with Yohimbine.
ZafirlukastThe metabolism of Alprazolam can be decreased when combined with Zafirlukast.
ZaleplonThe risk or severity of adverse effects can be increased when Alprazolam is combined with Zaleplon.
ZiconotideThe risk or severity of adverse effects can be increased when Alprazolam is combined with Ziconotide.
ZimelidineThe risk or severity of adverse effects can be increased when Alprazolam is combined with Zimelidine.
ZiprasidoneThe metabolism of Alprazolam can be decreased when combined with Ziprasidone.
ZiprasidoneThe risk or severity of adverse effects can be increased when Alprazolam is combined with Ziprasidone.
ZolazepamThe risk or severity of adverse effects can be increased when Alprazolam is combined with Zolazepam.
ZolpidemThe risk or severity of adverse effects can be increased when Alprazolam is combined with Zolpidem.
ZonisamideThe risk or severity of adverse effects can be increased when Alprazolam is combined with Zonisamide.
ZopicloneThe risk or severity of adverse effects can be increased when Alprazolam is combined with Zopiclone.
ZotepineThe risk or severity of adverse effects can be increased when Alprazolam is combined with Zotepine.
ZuclopenthixolThe risk or severity of adverse effects can be increased when Alprazolam is combined with Zuclopenthixol.
Food Interactions
  • Avoid alcohol.
  • Avoid excessive quantities of coffee or tea (Caffeine).
  • Avoid taking with grapefruit juice.
  • Take with food.

Targets

Kind
Protein group
Organism
Human
Pharmacological action
yes
Actions
positive allosteric modulator
General Function:
Inhibitory extracellular ligand-gated ion channel activity
Specific Function:
Component of the heteropentameric receptor for GABA, the major inhibitory neurotransmitter in the vertebrate brain. Functions also as histamine receptor and mediates cellular responses to histamine. Functions as receptor for diazepines and various anesthetics, such as pentobarbital; these are bound at a separate allosteric effector binding site. Functions as ligand-gated chloride channel (By similarity).
Components:
NameUniProt IDDetails
Gamma-aminobutyric acid receptor subunit alpha-1P14867 Details
Gamma-aminobutyric acid receptor subunit alpha-2P47869 Details
Gamma-aminobutyric acid receptor subunit alpha-3P34903 Details
Gamma-aminobutyric acid receptor subunit alpha-4P48169 Details
Gamma-aminobutyric acid receptor subunit alpha-5P31644 Details
Gamma-aminobutyric acid receptor subunit alpha-6Q16445 Details
Gamma-aminobutyric acid receptor subunit beta-1P18505 Details
Gamma-aminobutyric acid receptor subunit beta-2P47870 Details
Gamma-aminobutyric acid receptor subunit beta-3P28472 Details
Gamma-aminobutyric acid receptor subunit deltaO14764 Details
Gamma-aminobutyric acid receptor subunit epsilonP78334 Details
Gamma-aminobutyric acid receptor subunit gamma-1Q8N1C3 Details
Gamma-aminobutyric acid receptor subunit gamma-2P18507 Details
Gamma-aminobutyric acid receptor subunit gamma-3Q99928 Details
Gamma-aminobutyric acid receptor subunit piO00591 Details
Gamma-aminobutyric acid receptor subunit thetaQ9UN88 Details
References
  1. Riss J, Cloyd J, Gates J, Collins S: Benzodiazepines in epilepsy: pharmacology and pharmacokinetics. Acta Neurol Scand. 2008 Aug;118(2):69-86. doi: 10.1111/j.1600-0404.2008.01004.x. Epub 2008 Mar 31. [PubMed:18384456 ]
  2. Verster JC, Volkerts ER: Clinical pharmacology, clinical efficacy, and behavioral toxicity of alprazolam: a review of the literature. CNS Drug Rev. 2004 Spring;10(1):45-76. [PubMed:14978513 ]

Enzymes

Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrate
General Function:
Vitamin d3 25-hydroxylase activity
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It performs a variety of oxidation reactions (e.g. caffeine 8-oxidation, omeprazole sulphoxidation, midazolam 1'-hydroxylation and midazolam 4-hydroxylation) of structurally unrelated compounds, including steroids, fatty acids, and xenobiot...
Gene Name:
CYP3A4
Uniprot ID:
P08684
Molecular Weight:
57342.67 Da
References
  1. Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. [PubMed:19515014 ]
  2. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
  3. Williams JA, Ring BJ, Cantrell VE, Jones DR, Eckstein J, Ruterbories K, Hamman MA, Hall SD, Wrighton SA: Comparative metabolic capabilities of CYP3A4, CYP3A5, and CYP3A7. Drug Metab Dispos. 2002 Aug;30(8):883-91. [PubMed:12124305 ]
  4. Drug Interactions: Cytochrome P450 Drug Interaction Table [Link]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrate
General Function:
Steroid hydroxylase activity
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. This enzyme contributes to the wide pharmacokinetics variability of the metabolism of drugs such as S-warfarin, diclofenac, phenyto...
Gene Name:
CYP2C9
Uniprot ID:
P11712
Molecular Weight:
55627.365 Da
References
  1. Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. [PubMed:19515014 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrate
General Function:
Oxygen binding
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
Gene Name:
CYP3A5
Uniprot ID:
P20815
Molecular Weight:
57108.065 Da
References
  1. Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. [PubMed:19515014 ]
  2. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
  3. Drug Interactions: Cytochrome P450 Drug Interaction Table [Link]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrate
General Function:
Oxygen binding
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
Gene Name:
CYP3A7
Uniprot ID:
P24462
Molecular Weight:
57525.03 Da
References
  1. Drug Interactions: Cytochrome P450 Drug Interaction Table [Link]
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Drug created on June 13, 2005 07:24 / Updated on October 01, 2016 02:23