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Identification
NameChlordiazepoxide
Accession NumberDB00475  (APRD00682)
TypeSmall Molecule
GroupsApproved, Illicit
DescriptionAn anxiolytic benzodiazepine derivative with anticonvulsant, sedative, and amnesic properties. It has also been used in the symptomatic treatment of alcohol withdrawal. [PubChem]
Structure
Thumb
Synonyms
7-chloro-2-Methylamino-5-phenyl-3H-1,4-benzodiazepin-4-oxide
CDP
Chloradiazepoxide
Chlordiazepoxide base
Chlordiazepoxidum
Clopoxide
Helogaphen
Libritabs
Methaminodiazepoxide
Multum
Risolid
Silibrin
Tropium
External Identifiers Not Available
Approved Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Chlordiazepoxidecapsule5 mgoralAa Pharma Inc1981-12-31Not applicableCanada
Chlordiazepoxidecapsule10 mgoralAa Pharma Inc1981-12-31Not applicableCanada
Chlordiazepoxidecapsule25 mgoralAa Pharma Inc1981-12-31Not applicableCanada
Chlordiazepoxide Cap 10mgcapsule10 mgoralPro Doc Limitee1969-12-312010-07-13Canada
Chlordiazepoxide Cap 5mgcapsule5 mgoralPro Doc Limitee1976-12-312009-07-23Canada
Chlordiazepoxyde 25 Capcapsule25 mgoralDuchesnay Inc1981-12-312003-07-18Canada
Chlordiazepoxyde Cap 10mgcapsule10 mgoralDuchesnay Inc1978-12-312003-07-18Canada
Chlordiazepoxyde HCl Cap 25mgcapsule25 mgoralPro Doc Limitee1978-12-312010-07-13Canada
Corax Cap 10mgcapsule10 mgoralIcn Canada Ltd.1968-12-311998-08-13Canada
Corax Cap 25mgcapsule25 mgoralIcn Canada Ltd.1973-12-311998-08-13Canada
Corax Cap 5mgcapsule5 mgoralIcn Canada Ltd.1974-12-311998-08-13Canada
Medilium Cap 10 10mgcapsule10 mgoralMedic Laboratory LtÉe1970-12-311996-09-09Canada
Medilium Cap 5mgcapsule5 mgoralMedic Laboratory LtÉe1971-12-311996-09-09Canada
Novo-poxide 10mgcapsule10 mgoralNovopharm Limited1968-12-312005-08-10Canada
Novo-poxide 25mgcapsule25 mgoralNovopharm Limited1970-12-312005-08-10Canada
Novo-poxide 5mgcapsule5 mgoralNovopharm Limited1970-12-312005-08-10Canada
Approved Generic Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Chlordiazepoxidecapsule25 mg/1oralDIRECT RX2016-03-04Not applicableUs
Chlordiazepoxide Hydrochloridecapsule, gelatin coated5 mg/1oralSolco Healthcare US LLC2010-05-15Not applicableUs
Chlordiazepoxide Hydrochloridecapsule5 mg/1oralPhysicians Total Care, Inc.1993-01-01Not applicableUs
Chlordiazepoxide Hydrochloridecapsule10 mg/1oralBarr Laboratories Inc.1990-09-30Not applicableUs
Chlordiazepoxide Hydrochloridecapsule25 mg/1oralA S Medication Solutions Llc1976-07-02Not applicableUs
Chlordiazepoxide Hydrochloridecapsule10 mg/1oralbryant ranch prepack1990-09-30Not applicableUs
Chlordiazepoxide Hydrochloridecapsule5 mg/1oralREMEDYREPACK INC.2011-08-11Not applicableUs
Chlordiazepoxide Hydrochloridecapsule, gelatin coated5 mg/1oralGolden State Medical Supply, Inc.2010-05-15Not applicableUs
Chlordiazepoxide Hydrochloridecapsule, gelatin coated10 mg/1oralAv Kare, Inc.2002-09-26Not applicableUs
Chlordiazepoxide Hydrochloridecapsule25 mg/1oralA S Medication Solutions Llc1976-07-02Not applicableUs
Chlordiazepoxide Hydrochloridecapsule, gelatin coated10 mg/1oralSolco Healthcare US LLC2010-05-15Not applicableUs
Chlordiazepoxide Hydrochloridecapsule5 mg/1oralCardinal Health2011-04-01Not applicableUs
Chlordiazepoxide Hydrochloridecapsule5 mg/1oralBarr Laboratories Inc.1976-07-01Not applicableUs
Chlordiazepoxide Hydrochloridecapsule25 mg/1oralMylan Institutional Inc.1994-05-06Not applicableUs
Chlordiazepoxide Hydrochloridecapsule25 mg/1oralTYA Pharmaceuticals1976-07-02Not applicableUs
Chlordiazepoxide Hydrochloridecapsule25 mg/1oralREMEDYREPACK INC.2011-05-10Not applicableUs
Chlordiazepoxide Hydrochloridecapsule, gelatin coated10 mg/1oralGolden State Medical Supply, Inc.2010-05-15Not applicableUs
Chlordiazepoxide Hydrochloridecapsule, gelatin coated25 mg/1oralAv Kare, Inc.2002-09-26Not applicableUs
Chlordiazepoxide Hydrochloridecapsule10 mg/1oralPhysicians Total Care, Inc.1994-12-09Not applicableUs
Chlordiazepoxide Hydrochloridecapsule, gelatin coated25 mg/1oralSolco Healthcare US LLC2010-05-15Not applicableUs
Chlordiazepoxide Hydrochloridecapsule10 mg/1oralCardinal Health2011-04-01Not applicableUs
Chlordiazepoxide Hydrochloridecapsule25 mg/1oralBarr Laboratories Inc.1976-07-02Not applicableUs
Chlordiazepoxide Hydrochloridecapsule5 mg/1oralMylan Institutional Inc.1995-12-08Not applicableUs
Chlordiazepoxide Hydrochloridecapsule25 mg/1oralContract Pharmacy Services Pa2010-04-07Not applicableUs
Chlordiazepoxide Hydrochloridecapsule25 mg/1oralREMEDYREPACK INC.2011-10-31Not applicableUs
Chlordiazepoxide Hydrochloridecapsule, gelatin coated25 mg/1oralGolden State Medical Supply, Inc.2010-05-15Not applicableUs
Chlordiazepoxide Hydrochloridecapsule25 mg/1oralPhysicians Total Care, Inc.1993-03-24Not applicableUs
Chlordiazepoxide Hydrochloridecapsule25 mg/1oralPd Rx Pharmaceuticals, Inc.2010-12-06Not applicableUs
Chlordiazepoxide Hydrochloridecapsule25 mg/1oralREMEDYREPACK INC.2011-08-01Not applicableUs
Chlordiazepoxide Hydrochloridecapsule25 mg/1oralCardinal Health2011-04-01Not applicableUs
Chlordiazepoxide Hydrochloridecapsule, gelatin coated5 mg/1oralAv Kare, Inc.2002-09-26Not applicableUs
Chlordiazepoxide Hydrochloridecapsule10 mg/1oralMylan Institutional Inc.1996-03-05Not applicableUs
Chlordiazepoxide Hydrochloridecapsule25 mg/1oralbryant ranch prepack2010-12-06Not applicableUs
Chlordiazepoxide Hydrochloridecapsule25 mg/1oralREMEDYREPACK INC.2012-03-14Not applicableUs
Approved Over the Counter ProductsNot Available
Unapproved/Other Products Not Available
International Brands
NameCompany
AngirexNot Available
EleniumPolfa Tarchomin
KlopoxidNycomed
LibriumAbbott
NapotonNot Available
RadepurAWD
RisolidActavis
SilibrinNot Available
SonimenNot Available
Brand mixtures
NameLabellerIngredients
ChloraxAa Pharma Inc
Chlordiazepoxide and Amitriptyline HClPar Pharmaceutical Inc
Chlordiazepoxide and Amitriptyline HydrochlorideMylan Pharmaceuticals Inc.
Chlordiazepoxide Hydrochloride and Clidinium BromideAcella Pharmaceuticals, LLC
Chlordiazepoxide Hydrochloride/clidinium BromideAv Kare, Inc.
Corium CapIcn Canada Ltd.
LibraxValeant Pharmaceuticals International
Nu-chlorax Capsules USPNu Pharm Inc
Pro ChloraxPro Doc Limitee
Salts
Name/CASStructureProperties
Chlordiazepoxide Hydrochloride
438-41-5
Thumb
  • InChI Key: PRNVHVUEIITLRV-UHFFFAOYSA-N
  • Monoisotopic Mass: 335.059217531
  • Average Mass: 336.216
DBSALT000632
Categories
UNII6RZ6XEZ3CR
CAS number58-25-3
WeightAverage: 299.755
Monoisotopic: 299.082539792
Chemical FormulaC16H14ClN3O
InChI KeyInChIKey=ANTSCNMPPGJYLG-UHFFFAOYSA-N
InChI
InChI=1S/C16H14ClN3O/c1-18-15-10-20(21)16(11-5-3-2-4-6-11)13-9-12(17)7-8-14(13)19-15/h2-9H,10H2,1H3,(H,18,19)
IUPAC Name
7-chloro-2-(methylamino)-5-phenyl-3H-1,4λ⁵-benzodiazepin-4-one
SMILES
CNC1=NC2=C(C=C(Cl)C=C2)C(C2=CC=CC=C2)=N(=O)C1
Taxonomy
DescriptionThis compound belongs to the class of organic compounds known as 1,4-benzodiazepines. These are organic compounds containing a benzene ring fused to a 1,4-azepine.
KingdomOrganic compounds
Super ClassOrganoheterocyclic compounds
ClassBenzodiazepines
Sub Class1,4-benzodiazepines
Direct Parent1,4-benzodiazepines
Alternative Parents
Substituents
  • 1,4-benzodiazepine
  • Imidolactam
  • Benzenoid
  • Monocyclic benzene moiety
  • Aryl halide
  • Aryl chloride
  • Nitrone
  • Azacycle
  • Organic 1,3-dipolar compound
  • Propargyl-type 1,3-dipolar organic compound
  • Allyl-type 1,3-dipolar organic compound
  • Carboxylic acid amidine
  • Amidine
  • Hydrocarbon derivative
  • Organic salt
  • Organonitrogen compound
  • Organochloride
  • Organohalogen compound
  • Organic cation
  • Aromatic heteropolycyclic compound
Molecular FrameworkAromatic heteropolycyclic compounds
External Descriptors
Pharmacology
IndicationFor the management of anxiety disorders or for the short-term relief of symptoms of anxiety, withdrawal symptoms of acute alcoholism, and preoperative apprehension and anxiety.
PharmacodynamicsChlordiazepoxide has antianxiety, sedative, appetite-stimulating and weak analgesic actions. The drug seems to block EEG arousal from stimulation in the brain stem reticular formation. The drug has been studied extensively in many species of animals and these studies are suggestive of action on the limbic system of the brain, which recent evidence indicates is involved in emotional responses. Hostile monkeys were made tame by oral drug doses which did not cause sedation. Chlordiazepoxide revealed a "taming" action with the elimination of fear and aggression. The taming effect of chlordiazepoxide was further demonstrated in rats made vicious by lesions in the septal area of the brain. The drug dosage which effectively blocked the vicious reaction was well below the dose which caused sedation in these animals.
Mechanism of actionChlordiazepoxide binds to stereospecific benzodiazepine (BZD) binding sites on GABA (A) receptor complexes at several sites within the central nervous system, including the limbic system and reticular formation. This results in an increased binding of the inhibitory neurotransmitter GABA to the GABA(A) receptor.BZDs, therefore, enhance GABA-mediated chloride influx through GABA receptor channels, causing membrane hyperpolarization. The net neuro-inhibitory effects result in the observed sedative, hypnotic, anxiolytic, and muscle relaxant properties.
Related Articles
AbsorptionNot Available
Volume of distributionNot Available
Protein bindingNot Available
Metabolism

Hepatic.

Route of eliminationChlordiazepoxide is excreted in the urine, with 1% to 2% unchanged and 3% to 6% as conjugate.
Half life24-48 hours
ClearanceNot Available
ToxicityLD50=537 mg/kg (Orally in rats). Signs of overdose include respiratory depression, muscle weakness, somnolence (general depressed activity).
Affected organisms
  • Humans and other mammals
PathwaysNot Available
SNP Mediated EffectsNot Available
SNP Mediated Adverse Drug ReactionsNot Available
ADMET
Predicted ADMET features
PropertyValueProbability
Human Intestinal Absorption+1.0
Blood Brain Barrier+0.9758
Caco-2 permeable+0.5868
P-glycoprotein substrateSubstrate0.6705
P-glycoprotein inhibitor INon-inhibitor0.521
P-glycoprotein inhibitor IINon-inhibitor0.7434
Renal organic cation transporterNon-inhibitor0.5502
CYP450 2C9 substrateNon-substrate0.6991
CYP450 2D6 substrateNon-substrate0.9116
CYP450 3A4 substrateSubstrate0.7408
CYP450 1A2 substrateInhibitor0.7564
CYP450 2C9 inhibitorNon-inhibitor0.6038
CYP450 2D6 inhibitorNon-inhibitor0.7862
CYP450 2C19 inhibitorNon-inhibitor0.5
CYP450 3A4 inhibitorInhibitor0.7067
CYP450 inhibitory promiscuityHigh CYP Inhibitory Promiscuity0.6372
Ames testNon AMES toxic0.593
CarcinogenicityNon-carcinogens0.7108
BiodegradationNot ready biodegradable1.0
Rat acute toxicity2.8520 LD50, mol/kg Not applicable
hERG inhibition (predictor I)Weak inhibitor0.9198
hERG inhibition (predictor II)Non-inhibitor0.8828
ADMET data is predicted using admetSAR, a free tool for evaluating chemical ADMET properties. (23092397 )
Pharmacoeconomics
Manufacturers
  • Valeant pharmaceuticals international
  • Abbott laboratories pharmaceutical products div
  • Rachelle laboratories inc
  • Ascot hosp pharmaceuticals inc div travenol laboratories inc
  • Barr laboratories inc
  • John j ferrante
  • Halsey drug co inc
  • Impax laboratories inc
  • Ivax pharmaceuticals inc sub teva pharmaceuticals usa
  • Lederle laboratories div american cyanamid co
  • Mm mast and co
  • Mylan pharmaceuticals inc
  • Parke davis div warner lambert co
  • Pioneer pharmaceuticals inc
  • Purepac pharmaceutical co
  • Roxane laboratories inc
  • Sandoz inc
  • Superpharm corp
  • Teva pharmaceuticals usa inc
  • Usl pharma inc
  • Vangard laboratories inc div midway medical co
  • Watson laboratories inc
  • West ward pharmaceutical corp
  • Alra laboratories inc
Packagers
Dosage forms
FormRouteStrength
Capsuleoral10 mg
Capsuleoral25 mg
Capsuleoral5 mg
Tabletoral
Tablet, film coatedoral
Capsuleoral10 mg/1
Capsuleoral25 mg/1
Capsuleoral5 mg/1
Capsule, gelatin coatedoral10 mg/1
Capsule, gelatin coatedoral25 mg/1
Capsule, gelatin coatedoral5 mg/1
Capsuleoral
Prices
Unit descriptionCostUnit
Librax 2.5-5 mg capsule6.5USD capsule
Librax capsule5.78USD capsule
Librium 25 mg capsule2.14USD capsule
Limbitrol DS 10-25 mg tablet1.93USD tablet
Librium 10 mg capsule1.61USD capsule
Librium 5 mg capsule0.84USD capsule
Chlordiazepoxide 25 mg capsule0.72USD capsule
ChlordiazePOXIDE HCl 25 mg capsule0.32USD capsule
ChlordiazePOXIDE HCl 10 mg capsule0.31USD capsule
ChlordiazePOXIDE HCl 5 mg capsule0.31USD capsule
Chlordiazepoxide 5 mg capsule0.2USD capsule
Apo-Chlordiazepoxide 25 mg Capsule0.17USD capsule
Chlordiazepoxide 10 mg capsule0.14USD capsule
Apo-Chlordiazepoxide 10 mg Capsule0.11USD capsule
Apo-Chlordiazepoxide 5 mg Capsule0.07USD capsule
DrugBank does not sell nor buy drugs. Pricing information is supplied for informational purposes only.
PatentsNot Available
Properties
StateSolid
Experimental Properties
PropertyValueSource
melting point236-236.5Sternbach, L.H.; US. Patent 2,893,992; July 7,1959; assigned to Hoffmann-LaRoche, Inc.
water solubility2000 mg/LYALKOWSKY,SH & DANNENFELSER,RM (1992)
logP2.44HANSCH,C ET AL. (1995)
pKa4.8MERCK INDEX (1996)
Predicted Properties
PropertyValueSource
Water Solubility0.0199 mg/mLALOGPS
logP2.01ALOGPS
logP3.05ChemAxon
logS-4.2ALOGPS
pKa (Strongest Acidic)18.52ChemAxon
pKa (Strongest Basic)6.43ChemAxon
Physiological Charge0ChemAxon
Hydrogen Acceptor Count3ChemAxon
Hydrogen Donor Count1ChemAxon
Polar Surface Area53.14 Å2ChemAxon
Rotatable Bond Count1ChemAxon
Refractivity87.34 m3·mol-1ChemAxon
Polarizability30.97 Å3ChemAxon
Number of Rings3ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleYesChemAxon
Spectra
Mass Spec (NIST)Not Available
Spectra
Spectrum TypeDescriptionSplash Key
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, PositiveNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, PositiveNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, PositiveNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, NegativeNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, NegativeNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, NegativeNot Available
References
Synthesis Reference

Sternbach, L.H.; US. Patent 2,893,992; July 7,1959; assigned to Hoffmann-LaRoche, Inc.

General References
  1. Skerritt JH, Johnston GA: Enhancement of GABA binding by benzodiazepines and related anxiolytics. Eur J Pharmacol. 1983 May 6;89(3-4):193-8. [PubMed:6135616 ]
  2. Oishi R, Nishibori M, Itoh Y, Saeki K: Diazepam-induced decrease in histamine turnover in mouse brain. Eur J Pharmacol. 1986 May 27;124(3):337-42. [PubMed:3089825 ]
  3. Earley JV, Fryer RI, Ning RY: Quinazolines and 1,4-benzodiazepines. LXXXIX: Haptens useful in benzodiazepine immunoassay development. J Pharm Sci. 1979 Jul;68(7):845-50. [PubMed:458601 ]
  4. Olive G, Dreux C: [Pharmacologic bases of use of benzodiazepines in pereinatal medicine]. Arch Fr Pediatr. 1977 Jan;34(1):74-89. [PubMed:851373 ]
  5. Vozeh S: [Pharmacokinetic of benzodiazepines in old age]. Schweiz Med Wochenschr. 1981 Nov 21;111(47):1789-93. [PubMed:6118950 ]
External Links
ATC CodesN05BA02
AHFS Codes
  • 28:24.08
PDB EntriesNot Available
FDA labelNot Available
MSDSDownload (74.9 KB)
Interactions
Drug Interactions
Drug
7-NitroindazoleThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with 7-Nitroindazole.
AbirateroneThe metabolism of Chlordiazepoxide can be decreased when combined with Abiraterone.
AcepromazineThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Acepromazine.
AceprometazineThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Aceprometazine.
adipiplonThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with adipiplon.
AgomelatineThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Agomelatine.
AlfaxaloneThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Alfaxalone.
AlfentanilThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Alfentanil.
AlphacetylmethadolThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Alphacetylmethadol.
AlprazolamThe risk or severity of adverse effects can be increased when Alprazolam is combined with Chlordiazepoxide.
AminophyllineThe therapeutic efficacy of Chlordiazepoxide can be decreased when used in combination with Aminophylline.
AmiodaroneThe metabolism of Chlordiazepoxide can be decreased when combined with Amiodarone.
AmisulprideThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Amisulpride.
AmitriptylineThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Amitriptyline.
AmobarbitalThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Amobarbital.
AmoxapineThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Amoxapine.
AmperozideThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Amperozide.
AprepitantThe serum concentration of Chlordiazepoxide can be increased when it is combined with Aprepitant.
AripiprazoleThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Aripiprazole.
ArtemetherThe metabolism of Chlordiazepoxide can be decreased when combined with Artemether.
ArticaineThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Articaine.
AsenapineThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Asenapine.
AtazanavirThe metabolism of Chlordiazepoxide can be decreased when combined with Atazanavir.
AtomoxetineThe metabolism of Chlordiazepoxide can be decreased when combined with Atomoxetine.
AzaperoneThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Azaperone.
AzelastineChlordiazepoxide may increase the central nervous system depressant (CNS depressant) activities of Azelastine.
AzelastineThe risk or severity of adverse effects can be increased when Azelastine is combined with Chlordiazepoxide.
BaclofenThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Baclofen.
BarbitalThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Barbital.
BenzocaineThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Benzocaine.
Benzyl alcoholThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Benzyl alcohol.
BetaxololThe metabolism of Chlordiazepoxide can be decreased when combined with Betaxolol.
BexaroteneThe serum concentration of Chlordiazepoxide can be decreased when it is combined with Bexarotene.
BoceprevirThe metabolism of Chlordiazepoxide can be decreased when combined with Boceprevir.
BortezomibThe metabolism of Chlordiazepoxide can be decreased when combined with Bortezomib.
BosentanThe serum concentration of Chlordiazepoxide can be decreased when it is combined with Bosentan.
BrexpiprazoleThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Brexpiprazole.
BrimonidineBrimonidine may increase the central nervous system depressant (CNS depressant) activities of Chlordiazepoxide.
BrimonidineThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Brimonidine.
BromazepamThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Bromazepam.
BrompheniramineThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Brompheniramine.
BrotizolamThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Brotizolam.
BupivacaineThe risk or severity of adverse effects can be increased when Bupivacaine is combined with Chlordiazepoxide.
BuprenorphineThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Buprenorphine.
BupropionThe metabolism of Chlordiazepoxide can be decreased when combined with Bupropion.
BuspironeThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Buspirone.
ButabarbitalThe risk or severity of adverse effects can be increased when Butabarbital is combined with Chlordiazepoxide.
ButacaineThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Butacaine.
ButalbitalThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Butalbital.
ButambenThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Butamben.
ButethalThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Butethal.
ButorphanolThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Butorphanol.
CarbamazepineThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Carbamazepine.
CarbinoxamineThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Carbinoxamine.
CarfentanilThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Carfentanil.
CarisoprodolThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Carisoprodol.
CelecoxibThe metabolism of Chlordiazepoxide can be decreased when combined with Celecoxib.
CeritinibThe serum concentration of Chlordiazepoxide can be increased when it is combined with Ceritinib.
CetirizineThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Cetirizine.
Chloral hydrateThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Chloral hydrate.
ChlormezanoneThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Chlormezanone.
ChloroprocaineThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Chloroprocaine.
ChloroquineThe metabolism of Chlordiazepoxide can be decreased when combined with Chloroquine.
ChlorphenamineThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Chlorphenamine.
ChlorpromazineThe metabolism of Chlordiazepoxide can be decreased when combined with Chlorpromazine.
ChlorpromazineThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Chlorpromazine.
ChlorprothixeneThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Chlorprothixene.
ChlorzoxazoneThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Chlorzoxazone.
CholecalciferolThe metabolism of Chlordiazepoxide can be decreased when combined with Cholecalciferol.
CimetidineThe metabolism of Chlordiazepoxide can be decreased when combined with Cimetidine.
CinacalcetThe metabolism of Chlordiazepoxide can be decreased when combined with Cinacalcet.
CinchocaineThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Cinchocaine.
CitalopramThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Citalopram.
CitalopramThe metabolism of Chlordiazepoxide can be decreased when combined with Citalopram.
ClarithromycinThe metabolism of Chlordiazepoxide can be decreased when combined with Clarithromycin.
ClemastineThe metabolism of Chlordiazepoxide can be decreased when combined with Clemastine.
ClemastineThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Clemastine.
ClidiniumThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Clidinium.
ClobazamThe metabolism of Chlordiazepoxide can be decreased when combined with Clobazam.
ClobazamThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Clobazam.
clomethiazoleThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with clomethiazole.
ClomipramineThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Clomipramine.
ClomipramineThe metabolism of Chlordiazepoxide can be decreased when combined with Clomipramine.
ClonazepamThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Clonazepam.
ClonidineThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Clonidine.
ClorazepateThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Clorazepate.
ClotrimazoleThe metabolism of Chlordiazepoxide can be decreased when combined with Clotrimazole.
ClozapineThe metabolism of Chlordiazepoxide can be decreased when combined with Clozapine.
ClozapineThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Clozapine.
CobicistatThe serum concentration of Chlordiazepoxide can be increased when it is combined with Cobicistat.
CocaineThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Cocaine.
CodeineThe risk or severity of adverse effects can be increased when Codeine is combined with Chlordiazepoxide.
ConivaptanThe serum concentration of Chlordiazepoxide can be increased when it is combined with Conivaptan.
CrizotinibThe metabolism of Chlordiazepoxide can be decreased when combined with Crizotinib.
CyclizineThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Cyclizine.
CyclobenzaprineThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Cyclobenzaprine.
CyclosporineThe metabolism of Chlordiazepoxide can be decreased when combined with Cyclosporine.
CyproheptadineThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Cyproheptadine.
DabrafenibThe serum concentration of Chlordiazepoxide can be decreased when it is combined with Dabrafenib.
DantroleneThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Dantrolene.
DapiprazoleThe risk or severity of adverse effects can be increased when Dapiprazole is combined with Chlordiazepoxide.
DapoxetineThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Dapoxetine.
DarifenacinThe metabolism of Chlordiazepoxide can be decreased when combined with Darifenacin.
DarunavirThe serum concentration of Chlordiazepoxide can be increased when it is combined with Darunavir.
DasatinibThe serum concentration of Chlordiazepoxide can be increased when it is combined with Dasatinib.
DeferasiroxThe serum concentration of Chlordiazepoxide can be decreased when it is combined with Deferasirox.
DelavirdineThe metabolism of Chlordiazepoxide can be decreased when combined with Delavirdine.
deramciclaneThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with deramciclane.
DesfluraneThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Desflurane.
DesipramineThe metabolism of Chlordiazepoxide can be decreased when combined with Desipramine.
DesipramineThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Desipramine.
DesloratadineThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Desloratadine.
DetomidineThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Detomidine.
DexamethasoneThe serum concentration of Chlordiazepoxide can be decreased when it is combined with Dexamethasone.
DexbrompheniramineThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Dexbrompheniramine.
DexmedetomidineThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Dexmedetomidine.
DextromoramideThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Dextromoramide.
DextropropoxypheneThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Dextropropoxyphene.
DezocineThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Dezocine.
DiazepamThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Diazepam.
DifenoxinThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Difenoxin.
DihydrocodeineThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Dihydrocodeine.
DihydroergotamineThe metabolism of Chlordiazepoxide can be decreased when combined with Dihydroergotamine.
DihydroetorphineThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Dihydroetorphine.
DihydromorphineThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Dihydromorphine.
DiltiazemThe metabolism of Chlordiazepoxide can be decreased when combined with Diltiazem.
DimenhydrinateThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Dimenhydrinate.
DiphenhydramineThe metabolism of Chlordiazepoxide can be decreased when combined with Diphenhydramine.
DiphenhydramineThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Diphenhydramine.
DiphenoxylateThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Diphenoxylate.
DisulfiramThe serum concentration of Chlordiazepoxide can be increased when it is combined with Disulfiram.
DoramectinThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Doramectin.
DoxepinThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Doxepin.
DoxycyclineThe metabolism of Chlordiazepoxide can be decreased when combined with Doxycycline.
DoxylamineDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Chlordiazepoxide.
DoxylamineThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Doxylamine.
DPDPEThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with DPDPE.
DronabinolDronabinol may increase the central nervous system depressant (CNS depressant) activities of Chlordiazepoxide.
DronedaroneThe metabolism of Chlordiazepoxide can be decreased when combined with Dronedarone.
DroperidolThe risk or severity of adverse effects can be increased when Droperidol is combined with Chlordiazepoxide.
DrotebanolThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Drotebanol.
DuloxetineThe metabolism of Chlordiazepoxide can be decreased when combined with Duloxetine.
DyclonineThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Dyclonine.
DyphyllineThe therapeutic efficacy of Chlordiazepoxide can be decreased when used in combination with Dyphylline.
EcgonineThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Ecgonine.
ECGONINE METHYL ESTERThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with ECGONINE METHYL ESTER.
EfavirenzThe serum concentration of Chlordiazepoxide can be decreased when it is combined with Efavirenz.
EfavirenzThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Efavirenz.
EliglustatThe metabolism of Chlordiazepoxide can be decreased when combined with Eliglustat.
EnfluraneThe risk or severity of adverse effects can be increased when Enflurane is combined with Chlordiazepoxide.
EntacaponeThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Entacapone.
EnzalutamideThe serum concentration of Chlordiazepoxide can be decreased when it is combined with Enzalutamide.
ErythromycinThe metabolism of Chlordiazepoxide can be decreased when combined with Erythromycin.
EscitalopramThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Escitalopram.
Eslicarbazepine acetateThe serum concentration of Chlordiazepoxide can be decreased when it is combined with Eslicarbazepine acetate.
EstazolamThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Estazolam.
EszopicloneThe risk or severity of adverse effects can be increased when Eszopiclone is combined with Chlordiazepoxide.
EthanolChlordiazepoxide may increase the central nervous system depressant (CNS depressant) activities of Ethanol.
EthanolThe risk or severity of adverse effects can be increased when Ethanol is combined with Chlordiazepoxide.
EthchlorvynolThe risk or severity of adverse effects can be increased when Ethchlorvynol is combined with Chlordiazepoxide.
EthosuximideThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Ethosuximide.
EthotoinThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Ethotoin.
Ethyl carbamateThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Ethyl carbamate.
Ethyl loflazepateThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Ethyl loflazepate.
EthylmorphineThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Ethylmorphine.
EtidocaineThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Etidocaine.
EtifoxineThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Etifoxine.
EtizolamThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Etizolam.
EtomidateThe risk or severity of adverse effects can be increased when Etomidate is combined with Chlordiazepoxide.
EtoperidoneThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Etoperidone.
EtorphineThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Etorphine.
EtravirineThe serum concentration of Chlordiazepoxide can be decreased when it is combined with Etravirine.
EzogabineThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Ezogabine.
FelbamateThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Felbamate.
FencamfamineThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Fencamfamine.
FenfluramineThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Fenfluramine.
FentanylThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Fentanyl.
FexofenadineThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Fexofenadine.
FlibanserinThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Flibanserin.
FluconazoleThe metabolism of Chlordiazepoxide can be decreased when combined with Fluconazole.
FludiazepamThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Fludiazepam.
FlunarizineThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Flunarizine.
FlunitrazepamThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Flunitrazepam.
FluoxetineThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Fluoxetine.
FluoxetineThe metabolism of Chlordiazepoxide can be decreased when combined with Fluoxetine.
FlupentixolThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Flupentixol.
FluphenazineThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Fluphenazine.
FlurazepamThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Flurazepam.
FluspirileneThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Fluspirilene.
Fluticasone PropionateThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Fluticasone Propionate.
FluvoxamineThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Fluvoxamine.
FluvoxamineThe metabolism of Chlordiazepoxide can be decreased when combined with Fluvoxamine.
FosamprenavirThe metabolism of Chlordiazepoxide can be decreased when combined with Fosamprenavir.
FosaprepitantThe serum concentration of Chlordiazepoxide can be increased when it is combined with Fosaprepitant.
FosphenytoinThe serum concentration of Fosphenytoin can be increased when it is combined with Chlordiazepoxide.
FosphenytoinThe risk or severity of adverse effects can be increased when Fosphenytoin is combined with Chlordiazepoxide.
FospropofolThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Fospropofol.
Fusidic AcidThe serum concentration of Chlordiazepoxide can be increased when it is combined with Fusidic Acid.
GabapentinThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Gabapentin.
gabapentin enacarbilThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with gabapentin enacarbil.
Gamma Hydroxybutyric AcidThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Gamma Hydroxybutyric Acid.
GlutethimideThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Glutethimide.
GuanfacineThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Guanfacine.
HalazepamThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Halazepam.
HaloperidolThe metabolism of Chlordiazepoxide can be decreased when combined with Haloperidol.
HaloperidolThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Haloperidol.
HalothaneThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Halothane.
HeroinThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Heroin.
HexobarbitalThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Hexobarbital.
HydrocodoneThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Hydrocodone.
HydromorphoneThe risk or severity of adverse effects can be increased when Hydromorphone is combined with Chlordiazepoxide.
HydroxyzineHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Chlordiazepoxide.
HydroxyzineThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Hydroxyzine.
IdelalisibThe serum concentration of Chlordiazepoxide can be increased when it is combined with Idelalisib.
IloperidoneThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Iloperidone.
ImatinibThe metabolism of Chlordiazepoxide can be decreased when combined with Imatinib.
ImipramineThe metabolism of Chlordiazepoxide can be decreased when combined with Imipramine.
ImipramineThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Imipramine.
IndalpineThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Indalpine.
IndinavirThe metabolism of Chlordiazepoxide can be decreased when combined with Indinavir.
IsavuconazoniumThe metabolism of Chlordiazepoxide can be decreased when combined with Isavuconazonium.
IsofluraneThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Isoflurane.
IsoniazidThe metabolism of Chlordiazepoxide can be decreased when combined with Isoniazid.
IsradipineThe metabolism of Chlordiazepoxide can be decreased when combined with Isradipine.
ItraconazoleThe metabolism of Chlordiazepoxide can be decreased when combined with Itraconazole.
IvacaftorThe serum concentration of Chlordiazepoxide can be increased when it is combined with Ivacaftor.
KetamineThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Ketamine.
KetazolamThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Ketazolam.
KetobemidoneThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Ketobemidone.
KetoconazoleThe metabolism of Chlordiazepoxide can be decreased when combined with Ketoconazole.
LamotrigineThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Lamotrigine.
LevetiracetamThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Levetiracetam.
LevobupivacaineThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Levobupivacaine.
LevocabastineThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Levocabastine.
LevocetirizineThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Levocetirizine.
LevodopaThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Levodopa.
Levomethadyl AcetateThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Levomethadyl Acetate.
LevomilnacipranThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Levomilnacipran.
LevorphanolThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Levorphanol.
LidocaineThe risk or severity of adverse effects can be increased when Lidocaine is combined with Chlordiazepoxide.
LithiumThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Lithium.
LofentanilThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Lofentanil.
LopinavirThe metabolism of Chlordiazepoxide can be decreased when combined with Lopinavir.
LoratadineThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Loratadine.
LorazepamThe risk or severity of adverse effects can be increased when Lorazepam is combined with Chlordiazepoxide.
LorcaserinThe metabolism of Chlordiazepoxide can be decreased when combined with Lorcaserin.
LovastatinThe metabolism of Chlordiazepoxide can be decreased when combined with Lovastatin.
LoxapineThe risk or severity of adverse effects can be increased when Loxapine is combined with Chlordiazepoxide.
Lu AA21004The risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Lu AA21004.
LuliconazoleThe serum concentration of Chlordiazepoxide can be increased when it is combined with Luliconazole.
LumefantrineThe metabolism of Chlordiazepoxide can be decreased when combined with Lumefantrine.
LurasidoneThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Lurasidone.
Magnesium SulfateMagnesium Sulfate may increase the central nervous system depressant (CNS depressant) activities of Chlordiazepoxide.
Magnesium SulfateThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Magnesium Sulfate.
MaprotilineThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Maprotiline.
MeclizineThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Meclizine.
MedetomidineThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Medetomidine.
MelatoninThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Melatonin.
MelperoneThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Melperone.
MepivacaineThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Mepivacaine.
MeprobamateThe risk or severity of adverse effects can be increased when Meprobamate is combined with Chlordiazepoxide.
MesoridazineThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Mesoridazine.
MetaxaloneThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Metaxalone.
MethadoneChlordiazepoxide may increase the central nervous system depressant (CNS depressant) activities of Methadone.
MethadoneThe metabolism of Chlordiazepoxide can be decreased when combined with Methadone.
Methadyl AcetateThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Methadyl Acetate.
MethapyrileneThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Methapyrilene.
MethaqualoneThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Methaqualone.
MethocarbamolThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Methocarbamol.
MethohexitalThe risk or severity of adverse effects can be increased when Methohexital is combined with Chlordiazepoxide.
MethotrimeprazineThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Methotrimeprazine.
MethoxyfluraneThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Methoxyflurane.
MethsuximideThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Methsuximide.
MethylphenobarbitalThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Methylphenobarbital.
MetoprololThe metabolism of Chlordiazepoxide can be decreased when combined with Metoprolol.
MetyrosineChlordiazepoxide may increase the sedative activities of Metyrosine.
MidazolamThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Midazolam.
MifepristoneThe metabolism of Chlordiazepoxide can be decreased when combined with Mifepristone.
MilnacipranThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Milnacipran.
MinocyclineMinocycline may increase the central nervous system depressant (CNS depressant) activities of Chlordiazepoxide.
MirabegronThe metabolism of Chlordiazepoxide can be decreased when combined with Mirabegron.
MirtazapineChlordiazepoxide may increase the central nervous system depressant (CNS depressant) activities of Mirtazapine.
MirtazapineThe risk or severity of adverse effects can be increased when Mirtazapine is combined with Chlordiazepoxide.
MitotaneThe serum concentration of Chlordiazepoxide can be decreased when it is combined with Mitotane.
ModafinilThe serum concentration of Chlordiazepoxide can be decreased when it is combined with Modafinil.
MolindoneThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Molindone.
MorphineThe risk or severity of adverse effects can be increased when Morphine is combined with Chlordiazepoxide.
NabiloneNabilone may increase the central nervous system depressant (CNS depressant) activities of Chlordiazepoxide.
NabiloneThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Nabilone.
NafcillinThe serum concentration of Chlordiazepoxide can be decreased when it is combined with Nafcillin.
NalbuphineThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Nalbuphine.
NefazodoneThe metabolism of Chlordiazepoxide can be decreased when combined with Nefazodone.
NelfinavirThe metabolism of Chlordiazepoxide can be decreased when combined with Nelfinavir.
NetupitantThe serum concentration of Chlordiazepoxide can be increased when it is combined with Netupitant.
NevirapineThe metabolism of Chlordiazepoxide can be decreased when combined with Nevirapine.
NicardipineThe metabolism of Chlordiazepoxide can be decreased when combined with Nicardipine.
NilotinibThe metabolism of Chlordiazepoxide can be decreased when combined with Nilotinib.
NitrazepamThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Nitrazepam.
Nitrous oxideThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Nitrous oxide.
NormethadoneThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Normethadone.
NortriptylineThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Nortriptyline.
OlanzapineThe risk or severity of adverse effects can be increased when Olanzapine is combined with Chlordiazepoxide.
OlaparibThe metabolism of Chlordiazepoxide can be decreased when combined with Olaparib.
OlopatadineThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Olopatadine.
OndansetronThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Ondansetron.
OpiumThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Opium.
OrphenadrineChlordiazepoxide may increase the central nervous system depressant (CNS depressant) activities of Orphenadrine.
OrphenadrineThe risk or severity of adverse effects can be increased when Orphenadrine is combined with Chlordiazepoxide.
OsanetantThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Osanetant.
OsimertinibThe serum concentration of Chlordiazepoxide can be increased when it is combined with Osimertinib.
OxazepamThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Oxazepam.
OxprenololThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Oxprenolol.
OxybuprocaineThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Oxybuprocaine.
OxycodoneThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Oxycodone.
OxymorphoneThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Oxymorphone.
PalbociclibThe serum concentration of Chlordiazepoxide can be increased when it is combined with Palbociclib.
PaliperidoneThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Paliperidone.
PanobinostatThe metabolism of Chlordiazepoxide can be decreased when combined with Panobinostat.
ParaldehydeChlordiazepoxide may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.
ParaldehydeThe risk or severity of adverse effects can be increased when Paraldehyde is combined with Chlordiazepoxide.
ParoxetineThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Paroxetine.
ParoxetineThe metabolism of Chlordiazepoxide can be decreased when combined with Paroxetine.
Peginterferon alfa-2bThe serum concentration of Chlordiazepoxide can be decreased when it is combined with Peginterferon alfa-2b.
PentazocineThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Pentazocine.
PentobarbitalThe risk or severity of adverse effects can be increased when Pentobarbital is combined with Chlordiazepoxide.
PerampanelThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Perampanel.
PerospironeThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Perospirone.
PerphenazineThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Perphenazine.
PethidineThe risk or severity of adverse effects can be increased when Pethidine is combined with Chlordiazepoxide.
PhenobarbitalThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Phenobarbital.
PhenoxyethanolThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Phenoxyethanol.
PhenytoinThe serum concentration of Phenytoin can be increased when it is combined with Chlordiazepoxide.
PhenytoinThe risk or severity of adverse effects can be increased when Phenytoin is combined with Chlordiazepoxide.
PimozideThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Pimozide.
PipamperoneThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Pipamperone.
PipotiazineThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Pipotiazine.
PizotifenThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Pizotifen.
PomalidomideThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Pomalidomide.
PosaconazoleThe metabolism of Chlordiazepoxide can be decreased when combined with Posaconazole.
PramipexoleChlordiazepoxide may increase the sedative activities of Pramipexole.
PramocaineThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Pramocaine.
PrazepamThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Prazepam.
PregabalinThe risk or severity of adverse effects can be increased when Pregabalin is combined with Chlordiazepoxide.
PrilocaineThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Prilocaine.
PrimidoneThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Primidone.
ProcaineThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Procaine.
ProchlorperazineThe risk or severity of adverse effects can be increased when Prochlorperazine is combined with Chlordiazepoxide.
PromazineThe metabolism of Chlordiazepoxide can be decreased when combined with Promazine.
PromazineThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Promazine.
PromethazineThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Promethazine.
ProparacaineThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Proparacaine.
PropofolThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Propofol.
PropoxycaineThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Propoxycaine.
ProtriptylineThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Protriptyline.
PSD502The risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with PSD502.
QuazepamThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Quazepam.
QuetiapineThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Quetiapine.
QuinidineThe metabolism of Chlordiazepoxide can be decreased when combined with Quinidine.
QuinineThe metabolism of Chlordiazepoxide can be decreased when combined with Quinine.
RamelteonThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Ramelteon.
RanolazineThe metabolism of Chlordiazepoxide can be decreased when combined with Ranolazine.
RemifentanilThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Remifentanil.
RemoxiprideThe risk or severity of adverse effects can be increased when Remoxipride is combined with Chlordiazepoxide.
ReserpineThe risk or severity of adverse effects can be increased when Reserpine is combined with Chlordiazepoxide.
RifabutinThe metabolism of Chlordiazepoxide can be increased when combined with Rifabutin.
RifampicinThe metabolism of Chlordiazepoxide can be increased when combined with Rifampicin.
RifapentineThe metabolism of Chlordiazepoxide can be increased when combined with Rifapentine.
RisperidoneThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Risperidone.
RitonavirThe metabolism of Chlordiazepoxide can be decreased when combined with Ritonavir.
RolapitantThe metabolism of Chlordiazepoxide can be decreased when combined with Rolapitant.
RomifidineThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Romifidine.
RopiniroleChlordiazepoxide may increase the sedative activities of Ropinirole.
RopiniroleThe metabolism of Chlordiazepoxide can be decreased when combined with Ropinirole.
RopivacaineThe risk or severity of adverse effects can be increased when Ropivacaine is combined with Chlordiazepoxide.
RotigotineChlordiazepoxide may increase the sedative activities of Rotigotine.
RufinamideThe risk or severity of adverse effects can be increased when Rufinamide is combined with Chlordiazepoxide.
S-EthylisothioureaThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with S-Ethylisothiourea.
SaquinavirThe metabolism of Chlordiazepoxide can be decreased when combined with Saquinavir.
ScopolamineThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Scopolamine.
SecobarbitalThe risk or severity of adverse effects can be increased when Secobarbital is combined with Chlordiazepoxide.
SertindoleThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Sertindole.
SertralineThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Sertraline.
SertralineThe metabolism of Chlordiazepoxide can be decreased when combined with Sertraline.
SevofluraneThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Sevoflurane.
SildenafilThe metabolism of Chlordiazepoxide can be decreased when combined with Sildenafil.
SiltuximabThe serum concentration of Chlordiazepoxide can be decreased when it is combined with Siltuximab.
SimeprevirThe serum concentration of Chlordiazepoxide can be increased when it is combined with Simeprevir.
Sodium oxybateChlordiazepoxide may increase the central nervous system depressant (CNS depressant) activities of Sodium oxybate.
Sodium oxybateThe risk or severity of adverse effects can be increased when Sodium oxybate is combined with Chlordiazepoxide.
St. John's WortThe serum concentration of Chlordiazepoxide can be decreased when it is combined with St. John's Wort.
StiripentolThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Stiripentol.
SufentanilThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Sufentanil.
SulfisoxazoleThe metabolism of Chlordiazepoxide can be decreased when combined with Sulfisoxazole.
SulpirideThe risk or severity of adverse effects can be increased when Sulpiride is combined with Chlordiazepoxide.
SuvorexantThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Suvorexant.
TapentadolThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Tapentadol.
TasimelteonThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Tasimelteon.
TeduglutideThe serum concentration of Chlordiazepoxide can be increased when it is combined with Teduglutide.
TelaprevirThe metabolism of Chlordiazepoxide can be decreased when combined with Telaprevir.
TelithromycinThe metabolism of Chlordiazepoxide can be decreased when combined with Telithromycin.
TemazepamThe risk or severity of adverse effects can be increased when Temazepam is combined with Chlordiazepoxide.
TerbinafineThe metabolism of Chlordiazepoxide can be decreased when combined with Terbinafine.
TetrabenazineThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Tetrabenazine.
TetracaineThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Tetracaine.
TetrodotoxinThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Tetrodotoxin.
ThalidomideChlordiazepoxide may increase the central nervous system depressant (CNS depressant) activities of Thalidomide.
ThalidomideThe risk or severity of adverse effects can be increased when Thalidomide is combined with Chlordiazepoxide.
TheophyllineThe therapeutic efficacy of Chlordiazepoxide can be decreased when used in combination with Theophylline.
ThiamylalThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Thiamylal.
ThiopentalThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Thiopental.
ThioridazineThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Thioridazine.
ThiothixeneThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Thiothixene.
TiagabineThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Tiagabine.
TiclopidineThe metabolism of Chlordiazepoxide can be decreased when combined with Ticlopidine.
TiletamineThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Tiletamine.
TipranavirThe metabolism of Chlordiazepoxide can be decreased when combined with Tipranavir.
TizanidineThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Tizanidine.
TocilizumabThe serum concentration of Chlordiazepoxide can be decreased when it is combined with Tocilizumab.
TolcaponeThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Tolcapone.
TopiramateThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Topiramate.
TramadolThe risk or severity of adverse effects can be increased when Tramadol is combined with Chlordiazepoxide.
Trans-2-PhenylcyclopropylamineThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Trans-2-Phenylcyclopropylamine.
TranylcypromineThe metabolism of Chlordiazepoxide can be decreased when combined with Tranylcypromine.
TranylcypromineThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Tranylcypromine.
TrazodoneThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Trazodone.
TriazolamThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Triazolam.
TrifluoperazineThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Trifluoperazine.
TriflupromazineThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Triflupromazine.
TrimipramineThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Trimipramine.
TriprolidineThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Triprolidine.
Valproic AcidThe risk or severity of adverse effects can be increased when Valproic Acid is combined with Chlordiazepoxide.
VenlafaxineThe metabolism of Chlordiazepoxide can be decreased when combined with Venlafaxine.
VerapamilThe metabolism of Chlordiazepoxide can be decreased when combined with Verapamil.
VigabatrinThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Vigabatrin.
VilazodoneThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Vilazodone.
VoriconazoleThe metabolism of Chlordiazepoxide can be decreased when combined with Voriconazole.
VortioxetineThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Vortioxetine.
XylazineThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Xylazine.
YohimbineThe therapeutic efficacy of Chlordiazepoxide can be decreased when used in combination with Yohimbine.
ZaleplonThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Zaleplon.
ZiconotideThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Ziconotide.
ZimelidineThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Zimelidine.
ZiprasidoneThe metabolism of Chlordiazepoxide can be decreased when combined with Ziprasidone.
ZiprasidoneThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Ziprasidone.
ZolazepamThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Zolazepam.
ZolpidemThe risk or severity of adverse effects can be increased when Zolpidem is combined with Chlordiazepoxide.
ZonisamideThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Zonisamide.
ZopicloneThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Zopiclone.
ZotepineThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Zotepine.
ZuclopenthixolThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Zuclopenthixol.
Food Interactions
  • Avoid alcohol.
  • Take without regard to meals.

Targets

Kind
Protein group
Organism
Human
Pharmacological action
yes
Actions
positive allosteric modulator
General Function:
Inhibitory extracellular ligand-gated ion channel activity
Specific Function:
Component of the heteropentameric receptor for GABA, the major inhibitory neurotransmitter in the vertebrate brain. Functions also as histamine receptor and mediates cellular responses to histamine. Functions as receptor for diazepines and various anesthetics, such as pentobarbital; these are bound at a separate allosteric effector binding site. Functions as ligand-gated chloride channel (By similarity).
Components:
NameUniProt IDDetails
Gamma-aminobutyric acid receptor subunit alpha-1P14867 Details
Gamma-aminobutyric acid receptor subunit alpha-2P47869 Details
Gamma-aminobutyric acid receptor subunit alpha-3P34903 Details
Gamma-aminobutyric acid receptor subunit alpha-4P48169 Details
Gamma-aminobutyric acid receptor subunit alpha-5P31644 Details
Gamma-aminobutyric acid receptor subunit alpha-6Q16445 Details
Gamma-aminobutyric acid receptor subunit beta-1P18505 Details
Gamma-aminobutyric acid receptor subunit beta-2P47870 Details
Gamma-aminobutyric acid receptor subunit beta-3P28472 Details
Gamma-aminobutyric acid receptor subunit deltaO14764 Details
Gamma-aminobutyric acid receptor subunit epsilonP78334 Details
Gamma-aminobutyric acid receptor subunit gamma-1Q8N1C3 Details
Gamma-aminobutyric acid receptor subunit gamma-2P18507 Details
Gamma-aminobutyric acid receptor subunit gamma-3Q99928 Details
Gamma-aminobutyric acid receptor subunit piO00591 Details
Gamma-aminobutyric acid receptor subunit thetaQ9UN88 Details
References
  1. Skerritt JH, Johnston GA: Enhancement of GABA binding by benzodiazepines and related anxiolytics. Eur J Pharmacol. 1983 May 6;89(3-4):193-8. [PubMed:6135616 ]

Enzymes

Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrate
General Function:
Vitamin d3 25-hydroxylase activity
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It performs a variety of oxidation reactions (e.g. caffeine 8-oxidation, omeprazole sulphoxidation, midazolam 1'-hydroxylation and midazolam 4-hydroxylation) of structurally unrelated compounds, including steroids, fatty acids, and xenobiot...
Gene Name:
CYP3A4
Uniprot ID:
P08684
Molecular Weight:
57342.67 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrate
General Function:
Steroid hydroxylase activity
Specific Function:
Responsible for the metabolism of many drugs and environmental chemicals that it oxidizes. It is involved in the metabolism of drugs such as antiarrhythmics, adrenoceptor antagonists, and tricyclic antidepressants.
Gene Name:
CYP2D6
Uniprot ID:
P10635
Molecular Weight:
55768.94 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
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Drug created on June 13, 2005 07:24 / Updated on August 17, 2016 12:23