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Identification
NamePropranolol
Accession NumberDB00571  (APRD00194)
TypeSmall Molecule
GroupsApproved, Investigational
Description

A widely used non-cardioselective beta-adrenergic antagonist. Propranolol is used in the treatment or prevention of many disorders including acute myocardial infarction, arrhythmias, angina pectoris, hypertension, hypertensive emergencies, hyperthyroidism, migraine, pheochromocytoma, menopause, and anxiety. [PubChem]

Structure
Thumb
Synonyms
1-((1-Methylethyl)amino)-3-(1-naphthalenyloxy)-2-propanol
1-(isopropylamino)-3-(1-naphthyloxy)propan-2-ol
beta-Propranolol
Propanalol
Propanolol
Propranolol
Propranololo
Propranololum
β-Propranolol
External Identifiers Not Available
Approved Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Detensol Tab 10mgtablet10 mgoralDesbergers LtÉe, Division Of Technilab Inc.1980-12-311999-09-17Canada
Detensol Tab 120mgtablet120 mgoralDesbergers LtÉe, Division Of Technilab Inc.1981-12-311999-09-17Canada
Detensol Tab 40mgtablet40 mgoralDesbergers LtÉe, Division Of Technilab Inc.1980-12-311999-09-17Canada
Detensol Tab 80mgtablet80 mgoralDesbergers LtÉe, Division Of Technilab Inc.1980-12-311999-09-17Canada
Dom-propranolol Tabletstablet10 mgoralDominion Pharmacal1996-12-31Not applicableCanada
Dom-propranolol Tabletstablet40 mgoralDominion Pharmacal1996-12-31Not applicableCanada
Dom-propranolol Tablets - 80mgtablet80 mgoralDominion Pharmacal1996-12-31Not applicableCanada
Hemangeolsolution4.28 mg/mLoralPierre Fabre Pharmaceuticals, Inc.2014-04-14Not applicableUs
Inderal 20 Tab 20mgtablet20 mgoralAyerst Laboratories1984-12-311999-04-12Canada
Inderal 80 Tabtablet80 mgoralAyerst Laboratories1974-12-311996-09-10Canada
Inderal Injectable Liq 1mg/mlliquid1 mgintravenousWyeth Ayerst Canada Inc.1995-12-312003-04-17Canada
Inderal LAcapsule, extended release160 mg/1oralAkrimax Pharmaceuticals, LLC1983-04-19Not applicableUs
Inderal LAcapsule, extended release120 mg/1oralAkrimax Pharmaceuticals, LLC1983-04-19Not applicableUs
Inderal LAcapsule, extended release80 mg/1oralAkrimax Pharmaceuticals, LLC1983-04-19Not applicableUs
Inderal LAcapsule, extended release60 mg/1oralAkrimax Pharmaceuticals, LLC1983-04-19Not applicableUs
Inderal LA Cap 160mgcapsule (sustained-release)160 mgoralAyerst Laboratories1980-12-311996-09-10Canada
Inderal LA Cap 80mgcapsule (sustained-release)80 mgoralAyerst Laboratories1982-12-311996-09-10Canada
Inderal Tab 120mgtablet120 mgoralAyerst Laboratories1979-12-311997-08-15Canada
Inderal XLcapsule, extended release80 mg/1oralMist Pharmaceuticals, Llc2014-02-01Not applicableUs
Inderal XLcapsule, extended release120 mg/1oralMist Pharmaceuticals, Llc2014-02-01Not applicableUs
Inderal-10 Tab 10mgtablet10 mgoralWyeth Ayerst Canada Inc.1994-12-312004-07-27Canada
Inderal-120 Tab 120mgtablet120 mgoralWyeth Ayerst Canada Inc.1996-10-252001-02-02Canada
Inderal-20 Tab 20mgtablet20 mgoralWyeth Ayerst Canada Inc.1994-12-312002-05-17Canada
Inderal-40 Tab 40mgtablet40 mgoralWyeth Ayerst Canada Inc.1993-12-312002-05-17Canada
Inderal-80 Tab 80mgtablet80 mgoralWyeth Ayerst Canada Inc.1996-10-252001-05-07Canada
Inderal-LAcapsule (sustained-release)60 mgoralPfizer Canada Inc1995-12-31Not applicableCanada
Inderal-LAcapsule (sustained-release)160 mgoralPfizer Canada Inc1994-12-31Not applicableCanada
Inderal-LAcapsule (sustained-release)120 mgoralPfizer Canada Inc1994-12-31Not applicableCanada
Inderal-LAcapsule (sustained-release)80 mgoralPfizer Canada Inc1994-12-31Not applicableCanada
Innopran XLcapsule, extended release120 mg/1oralAkrimax Pharmaceuticals, LLC2013-06-01Not applicableUs
Innopran XLcapsule, extended release80 mg/1oralAkrimax Pharmaceuticals, LLC2013-06-01Not applicableUs
Novo-pranol Tab 120mgtablet120 mgoralNovopharm Limited1982-12-312005-08-10Canada
Nu-propranolol Tab 10mgtablet10 mgoralNu Pharm Inc1993-12-312012-09-04Canada
Nu-propranolol Tab 120mgtablet120 mgoralNu Pharm Inc1993-12-312012-09-04Canada
Nu-propranolol Tab 20mgtablet20 mgoralNu Pharm Inc1993-12-312012-09-04Canada
Nu-propranolol Tab 40mgtablet40 mgoralNu Pharm Inc1993-12-312012-09-04Canada
Nu-propranolol Tab 80mgtablet80 mgoralNu Pharm Inc1993-12-312012-09-04Canada
PMS-propranolol Tablets 10mgtablet10 mgoralPharmascience Inc1983-12-31Not applicableCanada
PMS-propranolol Tablets 120mgtablet120 mgoralPharmascience Inc1983-12-31Not applicableCanada
PMS-propranolol Tablets 40mgtablet40 mgoralPharmascience Inc1983-12-31Not applicableCanada
PMS-propranolol Tablets 80mgtablet80 mgoralPharmascience Inc1983-12-31Not applicableCanada
Propranolol Hydrochloride ERcapsule, extended release160 mg/1oralAmerican Health Packaging2015-03-31Not applicableUs
Propranolol Hydrochloride ERcapsule, extended release80 mg/1oralRouses Point Pharm1983-04-19Not applicableUs
Propranolol Hydrochloride ERcapsule, extended release80 mg/1oralBlenheim Pharmacal, Inc.2013-11-18Not applicableUs
Propranolol Hydrochloride ERcapsule, extended release120 mg/1oralAmerican Health Packaging2015-03-31Not applicableUs
Propranolol Hydrochloride ERcapsule, extended release60 mg/1oralRouses Point Pharm1983-04-19Not applicableUs
Propranolol Hydrochloride ERcapsule, extended release80 mg/1oralAmerican Health Packaging2013-07-05Not applicableUs
Propranolol Hydrochloride ERcapsule, extended release60 mg/1oralAmerican Health Packaging2013-07-05Not applicableUs
Propranolol Hydrochloride ERcapsule, extended release120 mg/1oralUnit Dose Services1983-04-19Not applicableUs
Propranolol Hydrochloride ERcapsule, extended release160 mg/1oralRouses Point Pharm1983-04-19Not applicableUs
Propranolol Hydrochloride ERcapsule, extended release120 mg/1oralRouses Point Pharm1983-04-19Not applicableUs
Propranolol Hydrochloride Injection USPsolution1 mgintravenousSandoz Canada Incorporated1996-10-04Not applicableCanada
Propranolol Hydrochloride Tablet 40mgtablet40 mgoralD.C. Labs Limited1982-12-312003-07-11Canada
Propranolol Tab 10mgtablet10 mgoralPro Doc Limitee1980-12-312010-07-13Canada
Propranolol Tab 40mgtablet40 mgoralPro Doc Limitee1980-12-312010-07-13Canada
Propranolol Tab 80mgtablet80 mgoralPro Doc Limitee1980-12-312010-07-13Canada
Propranolol-120 Tab 120mgtablet120 mgoralPro Doc Limitee1987-12-312010-07-13Canada
Propranolol-20 Tab 20mgtablet20 mgoralPro Doc Limitee1987-12-312010-07-13Canada
Teva-propranololtablet20 mgoralTeva Canada Limited1987-12-31Not applicableCanada
Teva-propranololtablet80 mgoralTeva Canada Limited1981-12-31Not applicableCanada
Teva-propranololtablet40 mgoralTeva Canada Limited1981-12-31Not applicableCanada
Teva-propranololtablet10 mgoralTeva Canada Limited1981-12-31Not applicableCanada
Approved Generic Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Apo Propranolol Tab 10mgtablet10 mgoralApotex Inc1980-12-31Not applicableCanada
Apo Propranolol Tab 120mgtablet120 mgoralApotex Inc1981-12-31Not applicableCanada
Apo Propranolol Tab 40mgtablet40 mgoralApotex Inc1980-12-31Not applicableCanada
Apo Propranolol Tab 80mgtablet80 mgoralApotex Inc1980-12-31Not applicableCanada
Apo-propranolol Tab 20mgtablet20 mgoralApotex Inc1986-12-31Not applicableCanada
Propranololinjection, solution1 mg/mLintravenousAPP Pharmaceuticals, LLC2001-09-07Not applicableUs
Propranololtablet10 mg/1oralSTAT Rx USA LLC1986-01-01Not applicableUs
Propranololinjection1 mg/mLintravenousGeneral Injectables & Vaccines, Inc2011-02-22Not applicableUs
Propranololinjection1 mg/mLintravenousPhysicians Total Care, Inc.2006-12-11Not applicableUs
Propranolol Hydrochloridetablet20 mg/1oralUDL Laboratories, Inc.1998-09-01Not applicableUs
Propranolol Hydrochloridetablet10 mg/1oralBlenheim Pharmacal, Inc.2013-11-18Not applicableUs
Propranolol Hydrochloridetablet10 mg/1oralPliva Inc.1990-09-30Not applicableUs
Propranolol Hydrochloridetablet20 mg/1oralQualitest Pharmaceuticals2010-06-21Not applicableUs
Propranolol Hydrochloridetablet80 mg/1oralREMEDYREPACK INC.2011-10-13Not applicableUs
Propranolol Hydrochloridecapsule, extended release80 mg/1oralMylan Pharmaceuticals Inc.2007-02-15Not applicableUs
Propranolol Hydrochloridecapsule, extended release60 mg/1oralMylan Pharmaceuticals Inc.2007-02-15Not applicableUs
Propranolol Hydrochloridecapsule, extended release80 mg/1oralUpsher Smith Laboratories, Inc.2011-05-02Not applicableUs
Propranolol Hydrochloridetablet10 mg/1oralAidarex Pharmaceuticals LLC2008-10-13Not applicableUs
Propranolol Hydrochloridesolution20 mg/5mLoralRoxane Laboratories, Inc1987-05-15Not applicableUs
Propranolol Hydrochloridetablet20 mg/1oralRebel Distributors Corp1986-01-01Not applicableUs
Propranolol Hydrochloridetablet10 mg/1oralState of Florida DOH Central Pharmacy2013-01-01Not applicableUs
Propranolol Hydrochloridetablet20 mg/1oralBlenheim Pharmacal, Inc.2013-11-18Not applicableUs
Propranolol Hydrochlorideinjection1 mg/mLintravenousGeneral Injectables & Vaccines, Inc2010-08-01Not applicableUs
Propranolol Hydrochloridetablet40 mg/1oralCardinal Health2011-09-20Not applicableUs
Propranolol Hydrochloridetablet40 mg/1oralUDL Laboratories, Inc.1998-09-01Not applicableUs
Propranolol Hydrochloridecapsule, extended release120 mg/1oralPhysicians Total Care, Inc.1994-03-14Not applicableUs
Propranolol Hydrochloridecapsule, extended release60 mg/1oralbryant ranch prepack2007-08-10Not applicableUs
Propranolol Hydrochloridetablet20 mg/1oralState of Florida DOH Central Pharmacy2014-01-01Not applicableUs
Propranolol Hydrochloridecapsule, extended release80 mg/1oralGolden State Medical Supply, Inc.2014-07-15Not applicableUs
Propranolol Hydrochloridecapsule, extended release80 mg/1oralZydus Pharmaceuticals (USA) Inc.2014-04-15Not applicableUs
Propranolol Hydrochloridetablet10 mg/1oralCardinal Health2004-03-04Not applicableUs
Propranolol Hydrochloridecapsule, extended release120 mg/1oralCadila Healthcare Limited2014-04-15Not applicableUs
Propranolol Hydrochloridecapsule, extended release80 mg/1oralAvera Mc Kennan Hospital2015-05-15Not applicableUs
Propranolol Hydrochloridetablet20 mg/1oralbryant ranch prepack2008-10-13Not applicableUs
Propranolol Hydrochloridetablet40 mg/1oralPd Rx Pharmaceuticals, Inc.2010-06-21Not applicableUs
Propranolol Hydrochloridetablet10 mg/1oralREMEDYREPACK INC.2011-08-04Not applicableUs
Propranolol Hydrochloridecapsule, extended release120 mg/1oralZydus Pharmaceuticals (USA) Inc.2014-04-15Not applicableUs
Propranolol Hydrochloridetablet20 mg/1oralAphena Pharma Solutions Tennessee, Llc2010-06-21Not applicableUs
Propranolol Hydrochloridetablet10 mg/1oralA S Medication Solutions2010-06-21Not applicableUs
Propranolol Hydrochloridetablet20 mg/1oralAidarex Pharmaceuticals LLC2008-10-13Not applicableUs
Propranolol Hydrochloridecapsule, extended release60 mg/1oralUnit Dose Services2007-08-10Not applicableUs
Propranolol Hydrochloridetablet10 mg/1oralNcs Health Care Of Ky, Inc Dba Vangard Labs1990-09-30Not applicableUs
Propranolol Hydrochloridetablet40 mg/1oralA S Medication Solutions Llc2010-06-21Not applicableUs
Propranolol Hydrochloridetablet10 mg/1oralQualitest Pharmaceuticals2010-06-21Not applicableUs
Propranolol Hydrochloridetablet60 mg/1oralMylan Pharmaceuticals Inc.1985-11-19Not applicableUs
Propranolol Hydrochloridecapsule, extended release60 mg/1oralUpsher Smith Laboratories, Inc.2011-05-02Not applicableUs
Propranolol Hydrochloridetablet20 mg/1oralREMEDYREPACK INC.2013-03-20Not applicableUs
Propranolol Hydrochloridetablet80 mg/1oralNorthstar Rx LLC2009-12-14Not applicableUs
Propranolol Hydrochloridetablet40 mg/1oralState of Florida DOH Central Pharmacy2009-07-01Not applicableUs
Propranolol Hydrochloridetablet40 mg/1oralREMEDYREPACK INC.2014-05-08Not applicableUs
Propranolol Hydrochloridetablet10 mg/1oralCardinal Health2011-09-20Not applicableUs
Propranolol Hydrochloridecapsule, extended release60 mg/1oralPhysicians Total Care, Inc.2007-03-30Not applicableUs
Propranolol Hydrochloridetablet10 mg/1oralbryant ranch prepack2008-10-13Not applicableUs
Propranolol Hydrochloridecapsule, extended release60 mg/1oralGolden State Medical Supply, Inc.2014-07-15Not applicableUs
Propranolol Hydrochloridecapsule, extended release60 mg/1oralZydus Pharmaceuticals (USA) Inc.2014-04-15Not applicableUs
Propranolol Hydrochloridecapsule, extended release80 mg/1oralCadila Healthcare Limited2014-04-15Not applicableUs
Propranolol Hydrochloridecapsule, extended release60 mg/1oralAvera Mc Kennan Hospital2015-03-11Not applicableUs
Propranolol Hydrochloridesolution20 mg/5mLoralCarilion Materials Management1987-05-15Not applicableUs
Propranolol Hydrochloridecapsule, extended release80 mg/1oralREMEDYREPACK INC.2011-07-28Not applicableUs
Propranolol Hydrochloridetablet40 mg/1oralPd Rx Pharmaceuticals, Inc.1986-05-13Not applicableUs
Propranolol Hydrochloridetablet40 mg/1oralUnit Dose Services2008-10-13Not applicableUs
Propranolol Hydrochloridetablet40 mg/1oralNcs Health Care Of Ky, Inc Dba Vangard Labs1985-11-19Not applicableUs
Propranolol Hydrochloridetablet20 mg/1oralA S Medication Solutions Llc2010-06-21Not applicableUs
Propranolol Hydrochloridetablet80 mg/1oralWatson Laboratories, Inc.1986-05-13Not applicableUs
Propranolol Hydrochloridetablet80 mg/1oralMylan Pharmaceuticals Inc.1985-11-19Not applicableUs
Propranolol Hydrochloridecapsule, extended release160 mg/1oralActavis Elizabeth LLC2007-08-10Not applicableUs
Propranolol Hydrochloridetablet80 mg/1oralHeritage Pharmaceuticals Inc.2008-10-13Not applicableUs
Propranolol Hydrochloridetablet60 mg/1oralNorthstar Rx LLC2009-12-14Not applicableUs
Propranolol Hydrochloridetablet20 mg/1oralState of Florida DOH Central Pharmacy2009-07-01Not applicableUs
Propranolol Hydrochloridetablet10 mg/1oralREMEDYREPACK INC.2012-09-24Not applicableUs
Propranolol Hydrochlorideinjection, solution1 mg/mLintravenousCardinal Health2003-02-26Not applicableUs
Propranolol Hydrochloridecapsule, extended release80 mg/1oralPhysicians Total Care, Inc.2013-06-27Not applicableUs
Propranolol Hydrochloridetablet20 mg/1oralClinical Solutions Wholesale2010-06-21Not applicableUs
Propranolol Hydrochloridetablet20 mg/1oralDispensing Solutions, Inc.2008-10-13Not applicableUs
Propranolol Hydrochloridecapsule, extended release60 mg/1oralCadila Healthcare Limited2014-04-15Not applicableUs
Propranolol Hydrochloridetablet10 mg/1oralLake Erie Medical DBA Quality Care Products LLC1990-09-30Not applicableUs
Propranolol Hydrochloridetablet10 mg/1oralAvera Mc Kennan Hospital2015-11-02Not applicableUs
Propranolol Hydrochloridecapsule, extended release60 mg/1oralREMEDYREPACK INC.2011-06-03Not applicableUs
Propranolol Hydrochloridecapsule, extended release160 mg/1oralNortec Development Associates, Inc2015-05-01Not applicableUs
Propranolol Hydrochloridetablet40 mg/1oralMylan Pharmaceuticals Inc.1985-11-19Not applicableUs
Propranolol Hydrochloridecapsule, extended release120 mg/1oralActavis Elizabeth LLC2007-08-10Not applicableUs
Propranolol Hydrochloridetablet60 mg/1oralHeritage Pharmaceuticals Inc.2008-10-13Not applicableUs
Propranolol Hydrochloridetablet40 mg/1oralNorthstar Rx LLC2009-12-14Not applicableUs
Propranolol Hydrochloridetablet40 mg/1oralState of Florida DOH Central Pharmacy2013-01-01Not applicableUs
Propranolol Hydrochloridecapsule, extended release160 mg/1oralBreckenridge Pharmaceutical, Inc.2013-03-11Not applicableUs
Propranolol Hydrochloridetablet20 mg/1oralCardinal Health2011-09-20Not applicableUs
Propranolol Hydrochloridecapsule, extended release160 mg/1oralPhysicians Total Care, Inc.2007-05-02Not applicableUs
Propranolol Hydrochloridetablet40 mg/1oralProficient Rx LP1990-09-30Not applicableUs
Propranolol Hydrochloridetablet10 mg/1oralClinical Solutions Wholesale, Llc1990-09-30Not applicableUs
Propranolol Hydrochloridecapsule, extended release60 mg/1oralCarilion Materials Management2007-08-10Not applicableUs
Propranolol Hydrochloridetablet20 mg/1oralTYA Pharmaceuticals2008-10-13Not applicableUs
Propranolol Hydrochloridetablet40 mg/1oralAvera Mc Kennan Hospital2015-04-08Not applicableUs
Propranolol Hydrochloridetablet50 mg/1oralREMEDYREPACK INC.2011-04-28Not applicableUs
Propranolol Hydrochloridecapsule, extended release120 mg/1oralNortec Development Associates, Inc2015-05-01Not applicableUs
Propranolol Hydrochloridetablet20 mg/1oralUnit Dose Services2008-10-13Not applicableUs
Propranolol Hydrochloridetablet20 mg/1oralNcs Health Care Of Ky, Inc Dba Vangard Labs1985-11-19Not applicableUs
Propranolol Hydrochloridetablet10 mg/1oralA S Medication Solutions Llc2008-10-13Not applicableUs
Propranolol Hydrochloridetablet40 mg/1oralWatson Laboratories, Inc.1986-05-13Not applicableUs
Propranolol Hydrochloridetablet20 mg/1oralState of Florida DOH Central Pharmacy2009-07-01Not applicableUs
Propranolol Hydrochloridecapsule, extended release120 mg/1oralBreckenridge Pharmaceutical, Inc.2013-03-11Not applicableUs
Propranolol Hydrochloridetablet10 mg/1oralCardinal Health2008-10-13Not applicableUs
Propranolol Hydrochloridetablet80 mg/1oralPhysicians Total Care, Inc.1995-08-18Not applicableUs
Propranolol Hydrochloridetablet40 mg/1oralDIRECT RX2014-01-01Not applicableUs
Propranolol Hydrochloridetablet20 mg/1oralClinical Solutions Wholesale, Llc1990-09-30Not applicableUs
Propranolol Hydrochloridetablet40 mg/1oralCarilion Materials Management2008-10-13Not applicableUs
Propranolol Hydrochloridetablet10 mg/1oralTYA Pharmaceuticals2008-10-13Not applicableUs
Propranolol Hydrochloridetablet20 mg/1oralAvera Mc Kennan Hospital2015-04-21Not applicableUs
Propranolol Hydrochloridetablet40 mg/1oralREMEDYREPACK INC.2011-04-19Not applicableUs
Propranolol Hydrochloridecapsule, extended release80 mg/1oralA S Medication Solutions2013-03-11Not applicableUs
Propranolol Hydrochloridecapsule, extended release80 mg/1oralNortec Development Associates, Inc2015-05-01Not applicableUs
Propranolol Hydrochloridetablet80 mg/1oralPliva Inc.1990-09-30Not applicableUs
Propranolol Hydrochloridetablet10 mg/1oralNcs Health Care Of Ky, Inc Dba Vangard Labs1985-11-19Not applicableUs
Propranolol Hydrochloridetablet10 mg/1oralA S Medication Solutions Llc2010-06-21Not applicableUs
Propranolol Hydrochloridetablet20 mg/1oralWatson Laboratories, Inc.1986-05-13Not applicableUs
Propranolol Hydrochloridetablet20 mg/1oralMylan Pharmaceuticals Inc.1985-11-19Not applicableUs
Propranolol Hydrochloridecapsule, extended release80 mg/1oralActavis Elizabeth LLC2007-08-10Not applicableUs
Propranolol Hydrochloridetablet40 mg/1oralHeritage Pharmaceuticals Inc.2008-10-13Not applicableUs
Propranolol Hydrochloridetablet20 mg/1oralNorthstar Rx LLC2009-12-14Not applicableUs
Propranolol Hydrochloridetablet10 mg/1oralREMEDYREPACK INC.2015-06-18Not applicableUs
Propranolol Hydrochloridecapsule, extended release160 mg/1oralLake Erie Medical DBA Quality Care Products LLC2013-03-11Not applicableUs
Propranolol Hydrochloridetablet20 mg/1oralCarilion Materials Management2010-06-21Not applicableUs
Propranolol Hydrochloridetablet40 mg/1oralbryant ranch prepack2008-10-13Not applicableUs
Propranolol Hydrochloridetablet20 mg/1oralPreferred Pharmaceuticals, Inc.2012-07-26Not applicableUs
Propranolol Hydrochloridetablet80 mg/1oralREMEDYREPACK INC.2011-04-19Not applicableUs
Propranolol Hydrochloridetablet20 mg/1oralREMEDYREPACK INC.2014-08-13Not applicableUs
Propranolol Hydrochloridecapsule, extended release60 mg/1oralNortec Development Associates, Inc2015-05-01Not applicableUs
Propranolol Hydrochloridetablet60 mg/1oralPliva Inc.1990-09-30Not applicableUs
Propranolol Hydrochloridetablet80 mg/1oralQualitest Pharmaceuticals2010-06-21Not applicableUs
Propranolol Hydrochloridetablet20 mg/1oralLake Erie Medical DBA Quality Care Products LLC2012-03-23Not applicableUs
Propranolol Hydrochloridetablet10 mg/1oralWatson Laboratories, Inc.1986-05-13Not applicableUs
Propranolol Hydrochloridetablet10 mg/1oralMylan Pharmaceuticals Inc.1985-11-19Not applicableUs
Propranolol Hydrochloridecapsule, extended release60 mg/1oralActavis Elizabeth LLC2007-08-10Not applicableUs
Propranolol Hydrochloridetablet20 mg/1oralHeritage Pharmaceuticals Inc.2008-10-13Not applicableUs
Propranolol Hydrochloridetablet10 mg/1oralNorthstar Rx LLC2009-12-14Not applicableUs
Propranolol Hydrochloridetablet10 mg/1oralState of Florida DOH Central Pharmacy2009-07-01Not applicableUs
Propranolol Hydrochloridecapsule, extended release80 mg/1oralBreckenridge Pharmaceutical, Inc.2013-03-11Not applicableUs
Propranolol Hydrochloridecapsule, extended release80 mg/1oralPhysicians Total Care, Inc.2007-02-05Not applicableUs
Propranolol Hydrochloridetablet20 mg/1oralPhysicians Total Care, Inc.1993-07-27Not applicableUs
Propranolol Hydrochloridetablet40 mg/1oralPreferred Pharmaceuticals, Inc.2012-07-26Not applicableUs
Propranolol Hydrochloridetablet10 mg/1oralREMEDYREPACK INC.2010-11-08Not applicableUs
Propranolol Hydrochloridetablet40 mg/1oralA S Medication Solutions2010-06-21Not applicableUs
Propranolol Hydrochloridetablet60 mg/1oralRebel Distributors Corp.2008-10-13Not applicableUs
Propranolol Hydrochloridetablet40 mg/1oralPliva Inc.1990-09-30Not applicableUs
Propranolol Hydrochloridetablet60 mg/1oralQualitest Pharmaceuticals2010-06-21Not applicableUs
Propranolol Hydrochloridetablet40 mg/1oralLake Erie Medical & Surgical Supply DBA Quality Care Products LLC2012-03-23Not applicableUs
Propranolol Hydrochloridecapsule, extended release160 mg/1oralMylan Pharmaceuticals Inc.2007-02-15Not applicableUs
Propranolol Hydrochloridecapsule, extended release160 mg/1oralUpsher Smith Laboratories, Inc.2011-05-02Not applicableUs
Propranolol Hydrochlorideinjection1 mg/mLintravenousWest ward Pharmaceutical Corp2008-01-31Not applicableUs
Propranolol Hydrochloridetablet10 mg/1oralHeritage Pharmaceuticals Inc.2008-10-13Not applicableUs
Propranolol Hydrochloridetablet20 mg/1oralState of Florida DOH Central Pharmacy2009-07-01Not applicableUs
Propranolol Hydrochloridecapsule, extended release60 mg/1oralBreckenridge Pharmaceutical, Inc.2013-03-11Not applicableUs
Propranolol Hydrochloridetablet60 mg/1oralPhysicians Total Care, Inc.2006-03-30Not applicableUs
Propranolol Hydrochloridetablet40 mg/1oralPhysicians Total Care, Inc.1996-12-09Not applicableUs
Propranolol Hydrochloridecapsule, extended release160 mg/1oralGolden State Medical Supply, Inc.2014-07-15Not applicableUs
Propranolol Hydrochloridetablet40 mg/1oralPd Rx Pharmaceuticals, Inc.2008-10-13Not applicableUs
Propranolol Hydrochloridetablet10 mg/1oralCarilion Materials Management1986-05-13Not applicableUs
Propranolol Hydrochloridetablet80 mg/1oralbryant ranch prepack1986-05-13Not applicableUs
Propranolol Hydrochloridetablet20 mg/1oralPliva Inc.1990-09-30Not applicableUs
Propranolol Hydrochloridetablet40 mg/1oralQualitest Pharmaceuticals2010-06-21Not applicableUs
Propranolol Hydrochloridetablet20 mg/1oralREMEDYREPACK INC.2011-05-24Not applicableUs
Propranolol Hydrochloridecapsule, extended release120 mg/1oralMylan Pharmaceuticals Inc.2007-02-15Not applicableUs
Propranolol Hydrochloridecapsule, extended release120 mg/1oralUpsher Smith Laboratories, Inc.2011-05-02Not applicableUs
Propranolol Hydrochloridesolution40 mg/5mLoralRoxane Laboratories, Inc1987-05-15Not applicableUs
Propranolol Hydrochloridetablet40 mg/1oralRebel Distributors Corp1986-01-01Not applicableUs
Propranolol Hydrochloridetablet40 mg/1oralBlenheim Pharmacal, Inc.2013-11-18Not applicableUs
Propranolol Hydrochloridetablet10 mg/1oralPhysicians Total Care, Inc.2003-02-27Not applicableUs
Propranolol Hydrochloridecapsule, extended release120 mg/1oralGolden State Medical Supply, Inc.2014-07-15Not applicableUs
Propranolol Hydrochloridetablet20 mg/1oralPd Rx Pharmaceuticals, Inc.1986-05-13Not applicableUs
Propranolol Hydrochloridecapsule, extended release160 mg/1oralCadila Healthcare Limited2014-04-15Not applicableUs
Propranolol Hydrochloridetablet20 mg/1oralbryant ranch prepack1986-05-13Not applicableUs
Propranolol Hydrochloridecapsule, extended release160 mg/1oralZydus Pharmaceuticals (USA) Inc.2014-04-15Not applicableUs
Propranolol Hydrochloridetablet40 mg/1oralAphena Pharma Solutions Tennessee, Llc2010-06-21Not applicableUs
Propranolol Hydrochloridetablet20 mg/1oralA S Medication Solutions2010-06-21Not applicableUs
Propranolol Hydrochloridetablet40 mg/1oralAidarex Pharmaceuticals LLC2008-10-13Not applicableUs
Propranolol Hyrochloridetablet10 mg/301oralNorthwind Pharmaceuticals2014-05-15Not applicableUs
Approved Over the Counter ProductsNot Available
Unapproved/Other Products Not Available
International Brands
NameCompany
AngilolNot Available
Bedranol SRNot Available
CardinolNot Available
CiplarNot Available
DeralinNot Available
DocitonNot Available
DuranolNot Available
InderalNot Available
IndoblocNot Available
INNOPRANNot Available
ProphyluxNot Available
SumialNot Available
Brand mixtures
NameLabellerIngredients
Inderide-40 TabWyeth Ayerst Canada Inc.
Inderide-80 TabWyeth Ayerst Canada Inc.
Propranolol Hydrochloride and HydrochlorothiazideMylan Pharmaceuticals Inc.
Propranolol ScopolamineTps
Salts
Name/CASStructureProperties
Propranolol Hydrochloride
318-98-9
Thumb
  • InChI Key: ZMRUPTIKESYGQW-UHFFFAOYNA-N
  • Monoisotopic Mass: 295.13390666
  • Average Mass: 295.804
DBSALT000549
Categories
UNII9Y8NXQ24VQ
CAS number525-66-6
WeightAverage: 259.3434
Monoisotopic: 259.157228921
Chemical FormulaC16H21NO2
InChI KeyInChIKey=AQHHHDLHHXJYJD-UHFFFAOYSA-N
InChI
InChI=1S/C16H21NO2/c1-12(2)17-10-14(18)11-19-16-9-5-7-13-6-3-4-8-15(13)16/h3-9,12,14,17-18H,10-11H2,1-2H3
IUPAC Name
1-(naphthalen-1-yloxy)-3-[(propan-2-yl)amino]propan-2-ol
SMILES
CC(C)NCC(O)COC1=CC=CC2=CC=CC=C12
Taxonomy
DescriptionThis compound belongs to the class of organic compounds known as naphthalenes. These are compounds containing a naphthalene moiety, which consists of two fused benzene rings.
KingdomOrganic compounds
Super ClassBenzenoids
ClassNaphthalenes
Sub ClassNot Available
Direct ParentNaphthalenes
Alternative Parents
Substituents
  • Naphthalene
  • Alkyl aryl ether
  • Secondary alcohol
  • 1,2-aminoalcohol
  • Secondary amine
  • Ether
  • Secondary aliphatic amine
  • Hydrocarbon derivative
  • Organooxygen compound
  • Organonitrogen compound
  • Amine
  • Alcohol
  • Aromatic homopolycyclic compound
Molecular FrameworkAromatic homopolycyclic compounds
External DescriptorsNot Available
Pharmacology
IndicationFor the prophylaxis of migraine.
PharmacodynamicsPropranolol, the prototype of the beta-adrenergic receptor antagonists, is a competitive, nonselective beta-blocker similar to nadolol without intrinsic sympathomimetic activity. Propanolol is a racemic compound; the l-isomer is responsible for adrenergic blocking activity.
Mechanism of actionPropranolol competes with sympathomimetic neurotransmitters such as catecholamines for binding at beta(1)-adrenergic receptors in the heart, inhibiting sympathetic stimulation. This results in a reduction in resting heart rate, cardiac output, systolic and diastolic blood pressure, and reflex orthostatic hypotension.
Related Articles
AbsorptionPropranolol is almost completely absorbed from the GI tract; however, plasma concentrations attained are quite variable among individuals.
Volume of distribution
  • 4 L
Protein bindingMore than 90%
Metabolism

Hepatic

SubstrateEnzymesProduct
Propranolol
N-desisopropylpropranololDetails
Propranolol
4'-hydroxypropanololDetails
Route of eliminationPropranolol is extensively metabolized with most metabolites appearing in the urine.
Half life4 hours
ClearanceNot Available
ToxicitySymptoms of overdose include bradycardia, cardiac failure, hypotension, and brochospasm. LD50=565 mg/kg (orally in mice).
Affected organisms
  • Humans and other mammals
Pathways
PathwayCategorySMPDB ID
Propranolol Action PathwayDrug actionSMP00307
SNP Mediated EffectsNot Available
SNP Mediated Adverse Drug ReactionsNot Available
ADMET
Predicted ADMET features
PropertyValueProbability
Human Intestinal Absorption+0.9944
Blood Brain Barrier-0.9031
Caco-2 permeable+0.6942
P-glycoprotein substrateSubstrate0.7079
P-glycoprotein inhibitor IInhibitor0.5588
P-glycoprotein inhibitor IINon-inhibitor0.8383
Renal organic cation transporterNon-inhibitor0.8177
CYP450 2C9 substrateNon-substrate0.7898
CYP450 2D6 substrateSubstrate0.8918
CYP450 3A4 substrateNon-substrate0.6463
CYP450 1A2 substrateInhibitor0.9106
CYP450 2C9 inhibitorNon-inhibitor0.9071
CYP450 2D6 inhibitorInhibitor0.8932
CYP450 2C19 inhibitorNon-inhibitor0.9026
CYP450 3A4 inhibitorNon-inhibitor0.924
CYP450 inhibitory promiscuityLow CYP Inhibitory Promiscuity0.8487
Ames testNon AMES toxic0.9392
CarcinogenicityNon-carcinogens0.9097
BiodegradationNot ready biodegradable0.9871
Rat acute toxicity2.5625 LD50, mol/kg Not applicable
hERG inhibition (predictor I)Weak inhibitor0.9185
hERG inhibition (predictor II)Inhibitor0.7092
ADMET data is predicted using admetSAR, a free tool for evaluating chemical ADMET properties. (23092397 )
Pharmacoeconomics
Manufacturers
  • Akrimax pharmaceuticals llc
  • Glaxosmithkline llc
  • Actavis elizabeth llc
  • Inwood laboratories inc sub forest laboratories inc
  • Mylan pharmaceuticals inc
  • Par pharmaceutical
  • Upsher smith laboratories inc
  • Roxane laboratories inc
  • App pharmaceuticals llc
  • Baxter healthcare corp anesthesia critical care
  • Bedford laboratories div ben venue laboratories inc
  • Hikma farmaceutica (portugal) sa
  • Sandoz canada inc
  • Smith and nephew solopak div smith and nephew
  • Solopak medical products inc
  • Morton grove pharmaceuticals inc
  • Wyeth ayerst laboratories
  • Clonmel healthcare ltd
  • Duramed pharmaceuticals inc sub barr laboratories inc
  • Interpharm inc
  • Ipca laboratories ltd
  • Ivax pharmaceuticals inc sub teva pharmaceuticals usa
  • Lederle laboratories div american cyanamid co
  • Mutual pharmaceutical co inc
  • Northstar healthcare holdings ltd
  • Par pharmaceutical inc
  • Pliva inc
  • Purepac pharmaceutical co
  • Sandoz inc
  • Schering corp sub schering plough corp
  • Superpharm corp
  • Teva pharmaceuticals usa inc
  • Vintage pharmaceuticals
  • Warner chilcott div warner lambert co
  • Warner chilcott inc
  • Watson laboratories inc
Packagers
Dosage forms
FormRouteStrength
Tabletoral120 mg
Tabletoral20 mg
Tabletoral10 mg
Tabletoral40 mg
Tabletoral80 mg
Solutionoral4.28 mg/mL
Liquidintravenous1 mg
Capsule (sustained-release)oral120 mg
Capsule (sustained-release)oral160 mg
Capsule (sustained-release)oral60 mg
Capsule (sustained-release)oral80 mg
Capsule, extended releaseoral120 mg/1
Capsule, extended releaseoral160 mg/1
Capsule, extended releaseoral60 mg/1
Capsule, extended releaseoral80 mg/1
Injectionintravenous1 mg/mL
Injection, solutionintravenous1 mg/mL
Solutionoral20 mg/5mL
Solutionoral40 mg/5mL
Tabletoral10 mg/1
Tabletoral20 mg/1
Tabletoral40 mg/1
Tabletoral50 mg/1
Tabletoral60 mg/1
Tabletoral80 mg/1
Tabletoral
Solutionintravenous1 mg
Tabletoral10 mg/301
Prices
Unit descriptionCostUnit
Propranolol hcl powder11.63USD g
Propranolol 1 mg/ml vial10.0USD ml
Inderal la 160 mg capsule8.41USD capsule
Inderal LA 160 mg 24 Hour Capsule7.6USD capsule
Inderal la 160 mg capsule sa7.01USD capsule
Inderal la 120 mg capsule6.42USD capsule
Inderal LA 120 mg 24 Hour Capsule5.8USD capsule
Inderal la 120 mg capsule sa5.36USD capsule
Inderal la 80 mg capsule5.18USD capsule
Inderal LA 60 mg 24 Hour Capsule4.79USD capsule
Inderal LA 80 mg 24 Hour Capsule4.68USD capsule
Inderal la 60 mg capsule4.43USD capsule
Inderal la 80 mg capsule sa4.32USD capsule
Inderal la 60 mg capsule sa3.7USD capsule
Propranolol HCl CR 160 mg 24 Hour Capsule2.62USD capsule
InnoPran XL 80 mg 24 Hour Capsule2.5USD capsule
InnoPran XL 120 mg 24 Hour Capsule2.46USD capsule
Innopran xl 120 mg capsule2.41USD capsule
Innopran xl 80 mg capsule2.41USD capsule
Inderide 80-25 mg tablet2.17USD tablet
Propranolol HCl CR 120 mg 24 Hour Capsule2.0USD capsule
Inderide 40-25 mg tablet1.74USD tablet
Propranolol HCl CR 80 mg 24 Hour Capsule1.61USD capsule
Propranolol HCl CR 60 mg 24 Hour Capsule1.38USD capsule
Propranolol HCl 60 mg tablet1.27USD tablet
Inderal-La 160 mg Sustained-Release Capsule1.26USD capsule
Inderal-La 120 mg Sustained-Release Capsule1.07USD capsule
Inderal-La 80 mg Sustained-Release Capsule0.69USD capsule
Propranolol HCl 80 mg tablet0.66USD tablet
Propranolol-HCTZ 80-25 mg tablet0.65USD tablet
Inderal-La 60 mg Sustained-Release Capsule0.62USD capsule
Propranolol-HCTZ 40-25 mg tablet0.61USD tablet
Propranolol 80 mg tablet0.58USD tablet
Propranolol 60 mg tablet0.56USD tablet
Propranolol HCl 40 mg tablet0.53USD tablet
Propranolol 40 mg tablet0.45USD tablet
Propranolol HCl 20 mg tablet0.36USD tablet
Propranolol 20 mg tablet0.33USD tablet
Apo-Propranolol 120 mg Tablet0.32USD tablet
Propranolol HCl 10 mg tablet0.29USD tablet
Propranolol 10 mg tablet0.22USD tablet
Propranolol HCl 20 mg/5ml Solution0.11USD ml
Apo-Propranolol 80 mg Tablet0.06USD tablet
Novo-Pranol 80 mg Tablet0.06USD tablet
Pms-Propranolol 80 mg Tablet0.06USD tablet
Apo-Propranolol 20 mg Tablet0.04USD tablet
Apo-Propranolol 40 mg Tablet0.04USD tablet
Novo-Pranol 20 mg Tablet0.04USD tablet
Novo-Pranol 40 mg Tablet0.04USD tablet
Apo-Propranolol 10 mg Tablet0.02USD tablet
Novo-Pranol 10 mg Tablet0.02USD tablet
DrugBank does not sell nor buy drugs. Pricing information is supplied for informational purposes only.
Patents
Patent NumberPediatric ExtensionApprovedExpires (estimated)
US6500454 No2001-10-042021-10-04Us
US8338489 No2008-10-162028-10-16Us
Properties
StateSolid
Experimental Properties
PropertyValueSource
melting point96 °CPhysProp
water solubility61.7 mg/L (at 25 °C)MCFARLAND,JW ET AL. (2001)
logP3.48AVDEEF,A (1997)
Caco2 permeability-4.58ADME Research, USCD
pKa9.42SANGSTER (1994)
Predicted Properties
PropertyValueSource
Water Solubility0.0794 mg/mLALOGPS
logP3.03ALOGPS
logP2.58ChemAxon
logS-3.5ALOGPS
pKa (Strongest Acidic)14.09ChemAxon
pKa (Strongest Basic)9.67ChemAxon
Physiological Charge1ChemAxon
Hydrogen Acceptor Count3ChemAxon
Hydrogen Donor Count2ChemAxon
Polar Surface Area41.49 Å2ChemAxon
Rotatable Bond Count6ChemAxon
Refractivity76.83 m3·mol-1ChemAxon
Polarizability29.98 Å3ChemAxon
Number of Rings2ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleYesChemAxon
Spectra
Mass Spec (NIST)Not Available
Spectra
Spectrum TypeDescriptionSplash Key
LC-MS/MSLC-MS/MS Spectrum - Quattro_QQQ 10V, Positive (Annotated)splash10-03di-0090000000-f8c39664b694f5784865View in MoNA
LC-MS/MSLC-MS/MS Spectrum - Quattro_QQQ 25V, Positive (Annotated)splash10-05fr-9000000000-84923a2dc3053801527aView in MoNA
LC-MS/MSLC-MS/MS Spectrum - Quattro_QQQ 40V, Positive (Annotated)splash10-0fk9-2932000000-fa245a17a643ef33a0b2View in MoNA
LC-MS/MSLC-MS/MS Spectrum - LC-ESI-QQ (API3000, Applied Biosystems) 10V, Positivesplash10-03di-0090000000-ee9d9c871e322202a948View in MoNA
LC-MS/MSLC-MS/MS Spectrum - LC-ESI-QQ (API3000, Applied Biosystems) 20V, Positivesplash10-03di-0290000000-9f3f72a6b6b792659137View in MoNA
LC-MS/MSLC-MS/MS Spectrum - LC-ESI-QQ (API3000, Applied Biosystems) 30V, Positivesplash10-0avi-5900000000-95293e6a5f843d0cc282View in MoNA
LC-MS/MSLC-MS/MS Spectrum - LC-ESI-QQ (API3000, Applied Biosystems) 40V, Positivesplash10-0ab9-9700000000-6b5b9e9743cb3f7bca58View in MoNA
LC-MS/MSLC-MS/MS Spectrum - LC-ESI-QQ (API3000, Applied Biosystems) 50V, Positivesplash10-0adi-9700000000-f5825268222d45a4ce95View in MoNA
LC-MS/MSLC-MS/MS Spectrum - LC-ESI-IT (LC/MSD Trap XCT, Agilent Technologies) , Positivesplash10-0159-1900000000-9872255282c6a95633aaView in MoNA
LC-MS/MSLC-MS/MS Spectrum - LC-ESI-IT (LC/MSD Trap XCT, Agilent Technologies) , Positivesplash10-00di-9500000000-122203085c028de6cbe4View in MoNA
LC-MS/MSLC-MS/MS Spectrum - LC-ESI-IT (LC/MSD Trap XCT, Agilent Technologies) , Positivesplash10-0aor-0900000000-39e75b6ae19b4763a0bfView in MoNA
LC-MS/MSLC-MS/MS Spectrum - LC-ESI-IT (LC/MSD Trap XCT, Agilent Technologies) , Positivesplash10-004i-0900000000-b75e7bf7aa20ce854157View in MoNA
LC-MS/MSLC-MS/MS Spectrum - LC-ESI-IT (LC/MSD Trap XCT, Agilent Technologies) , Positivesplash10-00di-9200000000-2f102916e2fe0f6c1f4bView in MoNA
1D NMR1H NMR SpectrumNot Available
2D NMR[1H,13C] 2D NMR SpectrumNot Available
References
Synthesis Reference

DrugSyn.org

US3520919
General References
  1. Brunet A, Orr SP, Tremblay J, Robertson K, Nader K, Pitman RK: Effect of post-retrieval propranolol on psychophysiologic responding during subsequent script-driven traumatic imagery in post-traumatic stress disorder. J Psychiatr Res. 2008 May;42(6):503-6. Epub 2007 Jun 22. [PubMed:17588604 ]
  2. Ohnishi ST, Sadanaga KK, Katsuoka M, Weidanz WP: Effects of membrane acting-drugs on plasmodium species and sickle cell erythrocytes. Mol Cell Biochem. 1989 Nov 23-Dec 19;91(1-2):159-65. [PubMed:2695829 ]
  3. Singh N, Puri SK: Interaction between chloroquine and diverse pharmacological agents in chloroquine resistant Plasmodium yoelii nigeriensis. Acta Trop. 2000 Nov 2;77(2):185-93. [PubMed:11080509 ]
  4. Murphy SC, Harrison T, Hamm HE, Lomasney JW, Mohandas N, Haldar K: Erythrocyte G protein as a novel target for malarial chemotherapy. PLoS Med. 2006 Dec;3(12):e528. [PubMed:17194200 ]
External Links
ATC CodesC07AA05C07BA05C07FA05
AHFS Codes
  • 24:24.00
PDB EntriesNot Available
FDA labelDownload (256 KB)
MSDSDownload (74.7 KB)
Interactions
Drug Interactions
Drug
AbirateroneThe serum concentration of Propranolol can be increased when it is combined with Abiraterone.
AcepromazineAcepromazine may increase the hypotensive activities of Propranolol.
AcetylcholineThe risk or severity of adverse effects can be increased when Propranolol is combined with Acetylcholine.
AfatinibThe serum concentration of Afatinib can be increased when it is combined with Propranolol.
AldesleukinThe risk or severity of adverse effects can be increased when Aldesleukin is combined with Propranolol.
AlfuzosinPropranolol may increase the orthostatic hypotensive activities of Alfuzosin.
AmifostinePropranolol may increase the hypotensive activities of Amifostine.
AmiodaroneAmiodarone may increase the bradycardic activities of Propranolol.
AripiprazoleThe serum concentration of Aripiprazole can be increased when it is combined with Propranolol.
BortezomibThe metabolism of Propranolol can be decreased when combined with Bortezomib.
BosutinibThe serum concentration of Bosutinib can be increased when it is combined with Propranolol.
Brentuximab vedotinThe serum concentration of Brentuximab vedotin can be increased when it is combined with Propranolol.
BretyliumBretylium may increase the bradycardic activities of Propranolol.
BrimonidineBrimonidine may increase the antihypertensive activities of Propranolol.
BupivacaineThe serum concentration of Bupivacaine can be increased when it is combined with Propranolol.
ButabarbitalThe serum concentration of Propranolol can be decreased when it is combined with Butabarbital.
ButethalThe serum concentration of Propranolol can be decreased when it is combined with Butethal.
CabergolinePropranolol may increase the vasoconstricting activities of Cabergoline.
CarbacholThe risk or severity of adverse effects can be increased when Propranolol is combined with Carbachol.
CarbamazepineThe metabolism of Propranolol can be increased when combined with Carbamazepine.
CeritinibPropranolol may increase the bradycardic activities of Ceritinib.
ChloroquineThe metabolism of Propranolol can be decreased when combined with Chloroquine.
ChlorpropamidePropranolol may increase the hypoglycemic activities of Chlorpropamide.
CholestyramineThe serum concentration of Propranolol can be decreased when it is combined with Cholestyramine.
CobicistatThe serum concentration of Propranolol can be increased when it is combined with Cobicistat.
ColchicineThe serum concentration of Colchicine can be increased when it is combined with Propranolol.
ColesevelamThe serum concentration of Propranolol can be decreased when it is combined with Colesevelam.
ColestipolThe serum concentration of Propranolol can be decreased when it is combined with Colestipol.
Cyproterone acetateThe serum concentration of Propranolol can be decreased when it is combined with Cyproterone acetate.
Dabigatran etexilateThe serum concentration of the active metabolites of Dabigatran etexilate can be increased when Dabigatran etexilate is used in combination with Propranolol.
DarunavirThe serum concentration of Propranolol can be increased when it is combined with Darunavir.
DeferasiroxThe serum concentration of Propranolol can be increased when it is combined with Deferasirox.
DiazoxideDiazoxide may increase the hypotensive activities of Propranolol.
DigoxinPropranolol may increase the bradycardic activities of Digoxin.
DipivefrinDipivefrin may increase the atrioventricular blocking (AV block) activities of Propranolol.
DipyridamoleDipyridamole may increase the bradycardic activities of Propranolol.
DisopyramideDisopyramide may increase the bradycardic activities of Propranolol.
DoxofyllineThe serum concentration of Doxofylline can be increased when it is combined with Propranolol.
DoxorubicinThe serum concentration of Doxorubicin can be increased when it is combined with Propranolol.
DronedaroneDronedarone may increase the bradycardic activities of Propranolol.
DuloxetinePropranolol may increase the orthostatic hypotensive activities of Duloxetine.
EdoxabanThe serum concentration of Edoxaban can be increased when it is combined with Propranolol.
EsmololEsmolol may increase the bradycardic activities of Propranolol.
EthanolThe serum concentration of Propranolol can be decreased when it is combined with Ethanol.
EverolimusThe serum concentration of Everolimus can be increased when it is combined with Propranolol.
FingolimodPropranolol may increase the bradycardic activities of Fingolimod.
FloctafenineThe risk or severity of adverse effects can be increased when Floctafenine is combined with Propranolol.
FluoxetineThe metabolism of Propranolol can be decreased when combined with Fluoxetine.
FluvoxamineThe serum concentration of Propranolol can be increased when it is combined with Fluvoxamine.
HeptabarbitalThe serum concentration of Propranolol can be decreased when it is combined with Heptabarbital.
HexobarbitalThe serum concentration of Propranolol can be decreased when it is combined with Hexobarbital.
InfliximabInfliximab may decrease the antihypertensive activities of Propranolol.
IvabradinePropranolol may increase the bradycardic activities of Ivabradine.
LacidipineLacidipine may increase the hypotensive activities of Propranolol.
LacosamidePropranolol may increase the atrioventricular blocking (AV block) activities of Lacosamide.
LedipasvirThe serum concentration of Ledipasvir can be increased when it is combined with Propranolol.
LevodopaPropranolol may increase the orthostatic hypotensive activities of Levodopa.
LidocaineThe serum concentration of Lidocaine can be increased when it is combined with Propranolol.
MepivacaineThe serum concentration of Mepivacaine can be increased when it is combined with Propranolol.
MethacholineThe risk or severity of adverse effects can be increased when Propranolol is combined with Methacholine.
MethohexitalThe serum concentration of Propranolol can be decreased when it is combined with Methohexital.
MethylphenidateMethylphenidate may decrease the antihypertensive activities of Propranolol.
MexiletineThe metabolism of Propranolol can be decreased when combined with Mexiletine.
MidodrinePropranolol may increase the bradycardic activities of Midodrine.
MolsidomineMolsidomine may increase the hypotensive activities of Propranolol.
MoxonidineMoxonidine may increase the hypotensive activities of Propranolol.
NaloxegolThe serum concentration of Naloxegol can be increased when it is combined with Propranolol.
NicorandilNicorandil may increase the hypotensive activities of Propranolol.
NifedipineNifedipine may increase the hypotensive activities of Propranolol.
ObinutuzumabPropranolol may increase the hypotensive activities of Obinutuzumab.
OctreotideOctreotide may increase the bradycardic activities of Propranolol.
OrciprenalinePropranolol may decrease the activities of Orciprenaline.
PanobinostatThe serum concentration of Propranolol can be increased when it is combined with Panobinostat.
ParoxetineThe serum concentration of Propranolol can be increased when it is combined with Paroxetine.
PazopanibThe serum concentration of Pazopanib can be increased when it is combined with Propranolol.
Peginterferon alfa-2bThe serum concentration of Propranolol can be decreased when it is combined with Peginterferon alfa-2b.
PentobarbitalThe serum concentration of Propranolol can be decreased when it is combined with Pentobarbital.
PentoxifyllinePentoxifylline may increase the hypotensive activities of Propranolol.
PhenelzinePhenelzine may increase the orthostatic hypotensive activities of Propranolol.
PrazosinPropranolol may increase the orthostatic hypotensive activities of Prazosin.
PrimidoneThe serum concentration of Propranolol can be decreased when it is combined with Primidone.
PropafenoneThe serum concentration of Propranolol can be increased when it is combined with Propafenone.
PrucaloprideThe serum concentration of Prucalopride can be increased when it is combined with Propranolol.
QuinidineThe serum concentration of Propranolol can be increased when it is combined with Quinidine.
QuinineQuinine may increase the hypotensive activities of Propranolol.
RanolazineThe serum concentration of Ranolazine can be increased when it is combined with Propranolol.
RegorafenibRegorafenib may increase the bradycardic activities of Propranolol.
ReserpineReserpine may increase the hypotensive activities of Propranolol.
RifaximinThe serum concentration of Rifaximin can be increased when it is combined with Propranolol.
RisperidonePropranolol may increase the hypotensive activities of Risperidone.
RitonavirThe metabolism of Propranolol can be decreased when combined with Ritonavir.
RituximabPropranolol may increase the hypotensive activities of Rituximab.
RivastigmineRivastigmine may increase the bradycardic activities of Propranolol.
RizatriptanThe serum concentration of Rizatriptan can be increased when it is combined with Propranolol.
RuxolitinibRuxolitinib may increase the bradycardic activities of Propranolol.
SaquinavirThe serum concentration of Saquinavir can be increased when it is combined with Propranolol.
SecobarbitalThe serum concentration of Propranolol can be decreased when it is combined with Secobarbital.
SilodosinThe serum concentration of Silodosin can be increased when it is combined with Propranolol.
SufentanilSufentanil may increase the bradycardic activities of Propranolol.
TacrineTacrine may increase the bradycardic activities of Propranolol.
TadalafilTadalafil may increase the antihypertensive activities of Propranolol.
TeriflunomideThe serum concentration of Propranolol can be decreased when it is combined with Teriflunomide.
TheophyllinePropranolol may decrease the activities of Theophylline.
TiclopidineThe metabolism of Propranolol can be decreased when combined with Ticlopidine.
TizanidineThe serum concentration of Tizanidine can be increased when it is combined with Propranolol.
TofacitinibTofacitinib may increase the bradycardic activities of Propranolol.
TopotecanThe serum concentration of Topotecan can be increased when it is combined with Propranolol.
TranylcypromineTranylcypromine may increase the orthostatic hypotensive activities of Propranolol.
TreprostinilTreprostinil may increase the hypotensive activities of Propranolol.
ValsartanThe risk or severity of adverse effects can be increased when Valsartan is combined with Propranolol.
VardenafilVardenafil may increase the antihypertensive activities of Propranolol.
VemurafenibThe serum concentration of Propranolol can be increased when it is combined with Vemurafenib.
VerapamilThe serum concentration of Verapamil can be increased when it is combined with Propranolol.
VincristineThe serum concentration of Vincristine can be increased when it is combined with Propranolol.
YohimbineYohimbine may decrease the antihypertensive activities of Propranolol.
ZileutonThe serum concentration of Propranolol can be increased when it is combined with Zileuton.
ZolmitriptanThe serum concentration of Zolmitriptan can be increased when it is combined with Propranolol.
Food Interactions
  • Avoid alcohol.
  • Avoid natural licorice.
  • Take with food.

Targets

Kind
Protein
Organism
Human
Pharmacological action
yes
Actions
antagonist
General Function:
Receptor signaling protein activity
Specific Function:
Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. This receptor binds epinephrine and norepinephrine with approximately equal affinity. Mediates Ras activation through G(s)-alpha- and cAMP-mediated signaling.
Gene Name:
ADRB1
Uniprot ID:
P08588
Molecular Weight:
51322.1 Da
References
  1. Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. [PubMed:11752352 ]
  2. Lewis CJ, Gong H, Brown MJ, Harding SE: Overexpression of beta 1-adrenoceptors in adult rat ventricular myocytes enhances CGP 12177A cardiostimulation: implications for 'putative' beta 4-adrenoceptor pharmacology. Br J Pharmacol. 2004 Mar;141(5):813-24. Epub 2004 Feb 2. [PubMed:14757703 ]
  3. Rouget C, Barthez O, Goirand F, Leroy MJ, Breuiller-Fouche M, Rakotoniaina Z, Guerard P, Morcillo EJ, Advenier C, Sagot P, Cabrol D, Dumas M, Bardou M: Stimulation of the ADRB3 adrenergic receptor induces relaxation of human placental arteries: influence of preeclampsia. Biol Reprod. 2006 Jan;74(1):209-16. Epub 2005 Sep 21. [PubMed:16177222 ]
  4. Horinouchi T, Morishima S, Tanaka T, Suzuki F, Tanaka Y, Koike K, Miwa S, Muramatsu I: Different changes of plasma membrane beta-adrenoceptors in rat heart after chronic administration of propranolol, atenolol and bevantolol. Life Sci. 2007 Jul 12;81(5):399-404. Epub 2007 Jun 16. [PubMed:17628611 ]
  5. Rezmann-Vitti LA, Louis SN, Nero TL, Jackman GP, Machida CA, Louis WJ: Site-directed mutagenesis of the rat beta1-adrenoceptor. Involvement of Tyr356 (7.43) in (+/-)cyanopindolol but not (+/-)[125Iodo]cyanopindolol binding. Eur J Med Chem. 2004 Jul;39(7):625-31. [PubMed:15236843 ]
  6. Yazawa K, Wang JW, Hao LY, Onoue Y, Kameyama M: Verrucotoxin, a stonefish venom, modulates calcium channel activity in guinea-pig ventricular myocytes. Br J Pharmacol. 2007 Aug;151(8):1198-203. Epub 2007 Jun 18. [PubMed:17572694 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
antagonist
General Function:
Protein homodimerization activity
Specific Function:
Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. The beta-2-adrenergic receptor binds epinephrine with an approximately 30-fold greater affinity than it does norepinephrine.
Gene Name:
ADRB2
Uniprot ID:
P07550
Molecular Weight:
46458.32 Da
References
  1. Isaza C, Henao J, Ramirez E, Cuesta F, Cacabelos R: Polymorphic variants of the beta2-adrenergic receptor (ADRB2) gene and ADRB2-related propanolol-induced dyslipidemia in the Colombian population. Methods Find Exp Clin Pharmacol. 2005 May;27(4):237-44. [PubMed:16082424 ]
  2. Rouget C, Barthez O, Goirand F, Leroy MJ, Breuiller-Fouche M, Rakotoniaina Z, Guerard P, Morcillo EJ, Advenier C, Sagot P, Cabrol D, Dumas M, Bardou M: Stimulation of the ADRB3 adrenergic receptor induces relaxation of human placental arteries: influence of preeclampsia. Biol Reprod. 2006 Jan;74(1):209-16. Epub 2005 Sep 21. [PubMed:16177222 ]
  3. Illingworth CJ, Gooding SR, Winn PJ, Jones GA, Ferenczy GG, Reynolds CA: Classical polarization in hybrid QM/MM methods. J Phys Chem A. 2006 May 25;110(20):6487-97. [PubMed:16706406 ]
  4. Horinouchi T, Morishima S, Tanaka T, Suzuki F, Tanaka Y, Koike K, Miwa S, Muramatsu I: Different changes of plasma membrane beta-adrenoceptors in rat heart after chronic administration of propranolol, atenolol and bevantolol. Life Sci. 2007 Jul 12;81(5):399-404. Epub 2007 Jun 16. [PubMed:17628611 ]
  5. Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. [PubMed:11752352 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
antagonist
General Function:
Protein homodimerization activity
Specific Function:
Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. Beta-3 is involved in the regulation of lipolysis and thermogenesis.
Gene Name:
ADRB3
Uniprot ID:
P13945
Molecular Weight:
43518.615 Da
References
  1. Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. [PubMed:11752352 ]
  2. Berg T, Piercey BW, Jensen J: Role of beta1-3-adrenoceptors in blood pressure control at rest and during tyramine-induced norepinephrine release in spontaneously hypertensive rats. Hypertension. 2010 May;55(5):1224-30. doi: 10.1161/HYPERTENSIONAHA.109.149286. Epub 2010 Mar 15. [PubMed:20231523 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
other/unknown
General Function:
Serotonin receptor activity
Specific Function:
G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various drugs and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Beta-arrestin family members inhibit signaling via G pro...
Gene Name:
HTR1A
Uniprot ID:
P08908
Molecular Weight:
46106.335 Da
References
  1. Smejkal-Jagar L, Boranic M: Serotonin and serotoninergic agents affect proliferation of normal and transformed lymphoid cells. Immunopharmacol Immunotoxicol. 1995 Feb;17(1):151-62. [PubMed:7759768 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
other/unknown
General Function:
Serotonin receptor activity
Specific Function:
G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for ergot alkaloid derivatives, various anxiolytic and antidepressant drugs and other psychoactive substances, such as lysergic acid diethylamide (LSD). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of ...
Gene Name:
HTR1B
Uniprot ID:
P28222
Molecular Weight:
43567.535 Da
References
  1. Bailey SR, Elliott J: Evidence for different 5-HT1B/1D receptors mediating vasoconstriction of equine digital arteries and veins. Eur J Pharmacol. 1998 Aug 21;355(2-3):175-87. [PubMed:9760032 ]
  2. Choppin A, O'Connor SE: Presence of vasoconstrictor 5HT1-like receptors revealed by precontraction of rabbit isolated mesenteric artery. Br J Pharmacol. 1995 Jan;114(2):309-14. [PubMed:7881730 ]

Enzymes

Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrateinhibitor
General Function:
Oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. Most active in catalyzing 2-hydroxylation. Caffeine is metabolized primarily by cytochrome CYP1A2 in the liver through an initial N...
Gene Name:
CYP1A2
Uniprot ID:
P05177
Molecular Weight:
58293.76 Da
References
  1. Yoshimoto K, Echizen H, Chiba K, Tani M, Ishizaki T: Identification of human CYP isoforms involved in the metabolism of propranolol enantiomers--N-desisopropylation is mediated mainly by CYP1A2. Br J Clin Pharmacol. 1995 Apr;39(4):421-31. [PubMed:7640150 ]
  2. Brosen K: Drug interactions and the cytochrome P450 system. The role of cytochrome P450 1A2. Clin Pharmacokinet. 1995;29 Suppl 1:20-5. [PubMed:8846619 ]
  3. Wang B, Zhou SF: Synthetic and natural compounds that interact with human cytochrome P450 1A2 and implications in drug development. Curr Med Chem. 2009;16(31):4066-218. [PubMed:19754423 ]
  4. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
  5. Carrillo JA, Benitez J: Clinically significant pharmacokinetic interactions between dietary caffeine and medications. Clin Pharmacokinet. 2000 Aug;39(2):127-53. [PubMed:10976659 ]
  6. Masubuchi Y, Hosokawa S, Horie T, Suzuki T, Ohmori S, Kitada M, Narimatsu S: Cytochrome P450 isozymes involved in propranolol metabolism in human liver microsomes. The role of CYP2D6 as ring-hydroxylase and CYP1A2 as N-desisopropylase. Drug Metab Dispos. 1994 Nov-Dec;22(6):909-15. [PubMed:7895609 ]
  7. Drug Interactions: Cytochrome P450 Drug Interaction Table [Link]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrateinhibitor
General Function:
Steroid hydroxylase activity
Specific Function:
Responsible for the metabolism of many drugs and environmental chemicals that it oxidizes. It is involved in the metabolism of drugs such as antiarrhythmics, adrenoceptor antagonists, and tricyclic antidepressants.
Gene Name:
CYP2D6
Uniprot ID:
P10635
Molecular Weight:
55768.94 Da
References
  1. Yoshimoto K, Echizen H, Chiba K, Tani M, Ishizaki T: Identification of human CYP isoforms involved in the metabolism of propranolol enantiomers--N-desisopropylation is mediated mainly by CYP1A2. Br J Clin Pharmacol. 1995 Apr;39(4):421-31. [PubMed:7640150 ]
  2. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
  3. Lewis DF, Modi S, Dickins M: Structure-activity relationship for human cytochrome P450 substrates and inhibitors. Drug Metab Rev. 2002 Feb-May;34(1-2):69-82. [PubMed:11996013 ]
  4. Drug Interactions: Cytochrome P450 Drug Interaction Table [Link]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrate
General Function:
Steroid hydroxylase activity
Specific Function:
Responsible for the metabolism of a number of therapeutic agents such as the anticonvulsant drug S-mephenytoin, omeprazole, proguanil, certain barbiturates, diazepam, propranolol, citalopram and imipramine.
Gene Name:
CYP2C19
Uniprot ID:
P33261
Molecular Weight:
55930.545 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
  2. Drug Interactions: Cytochrome P450 Drug Interaction Table [Link]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrate
General Function:
Vitamin d3 25-hydroxylase activity
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It performs a variety of oxidation reactions (e.g. caffeine 8-oxidation, omeprazole sulphoxidation, midazolam 1'-hydroxylation and midazolam 4-hydroxylation) of structurally unrelated compounds, including steroids, fatty acids, and xenobiot...
Gene Name:
CYP3A4
Uniprot ID:
P08684
Molecular Weight:
57342.67 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
  2. Drug Interactions: Cytochrome P450 Drug Interaction Table [Link]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrate
General Function:
Oxygen binding
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
Gene Name:
CYP3A5
Uniprot ID:
P20815
Molecular Weight:
57108.065 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
  2. Drug Interactions: Cytochrome P450 Drug Interaction Table [Link]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrate
General Function:
Oxygen binding
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
Gene Name:
CYP3A7
Uniprot ID:
P24462
Molecular Weight:
57525.03 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
  2. Drug Interactions: Cytochrome P450 Drug Interaction Table [Link]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Vitamin d 24-hydroxylase activity
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
Gene Name:
CYP1A1
Uniprot ID:
P04798
Molecular Weight:
58164.815 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]

Carriers

Kind
Protein
Organism
Human
Pharmacological action
no
General Function:
Not Available
Specific Function:
Functions as transport protein in the blood stream. Binds various ligands in the interior of its beta-barrel domain. Also binds synthetic drugs and influences their distribution and availability in the body. Appears to function in modulating the activity of the immune system during the acute-phase reaction.
Gene Name:
ORM1
Uniprot ID:
P02763
Molecular Weight:
23511.38 Da
References
  1. Ferry DG, Caplan NB, Cubeddu LX: Interaction between antidepressants and alpha 1-adrenergic receptor antagonists on the binding to alpha 1-acid glycoprotein. J Pharm Sci. 1986 Feb;75(2):146-9. [PubMed:2870173 ]

Transporters

Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Quaternary ammonium group transmembrane transporter activity
Specific Function:
Mediates tubular uptake of organic compounds from circulation. Mediates the influx of agmatine, dopamine, noradrenaline (norepinephrine), serotonin, choline, famotidine, ranitidine, histamin, creatinine, amantadine, memantine, acriflavine, 4-[4-(dimethylamino)-styryl]-N-methylpyridinium ASP, amiloride, metformin, N-1-methylnicotinamide (NMN), tetraethylammonium (TEA), 1-methyl-4-phenylpyridiniu...
Gene Name:
SLC22A2
Uniprot ID:
O15244
Molecular Weight:
62579.99 Da
References
  1. Dudley AJ, Bleasby K, Brown CD: The organic cation transporter OCT2 mediates the uptake of beta-adrenoceptor antagonists across the apical membrane of renal LLC-PK(1) cell monolayers. Br J Pharmacol. 2000 Sep;131(1):71-9. [PubMed:10960071 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrateinhibitor
General Function:
Xenobiotic-transporting atpase activity
Specific Function:
Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells.
Gene Name:
ABCB1
Uniprot ID:
P08183
Molecular Weight:
141477.255 Da
References
  1. Nagy H, Goda K, Fenyvesi F, Bacso Z, Szilasi M, Kappelmayer J, Lustyik G, Cianfriglia M, Szabo G Jr: Distinct groups of multidrug resistance modulating agents are distinguished by competition of P-glycoprotein-specific antibodies. Biochem Biophys Res Commun. 2004 Mar 19;315(4):942-9. [PubMed:14985103 ]
  2. D'Emanuele A, Jevprasesphant R, Penny J, Attwood D: The use of a dendrimer-propranolol prodrug to bypass efflux transporters and enhance oral bioavailability. J Control Release. 2004 Mar 24;95(3):447-53. [PubMed:15023456 ]
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Drug created on June 13, 2005 07:24 / Updated on May 31, 2016 02:13