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Identification
NameGabapentin
Accession NumberDB00996  (APRD00015)
TypeSmall Molecule
GroupsApproved, Investigational
Description

Gabapentin (brand name Neurontin) is a medication originally developed for the treatment of epilepsy. Presently, gabapentin is widely used to relieve pain, especially neuropathic pain. Gabapentin is well tolerated in most patients, has a relatively mild side-effect profile, and passes through the body unmetabolized.

Structure
Thumb
Synonyms
SynonymLanguageCode
1-(Aminomethyl)cyclohexaneacetic acidNot AvailableNot Available
Gabapentin GRNot AvailableNot Available
GabapentinaNot AvailableNot Available
GabapentineFrenchINN
GabapentinoSpanishNot Available
GabapentinumLatinINN
GabapetinNot AvailableNot Available
NeurontinNot AvailableNot Available
Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Neurontintablet, film coated800 mgoralParke Davis Div Of Pfizer Inc1998-10-09Not AvailableUs
Neurontintablet, film coated600 mgoralParke Davis Div Of Pfizer Inc1998-10-09Not AvailableUs
Neurontincapsule100 mgoralParke Davis Div Of Pfizer Inc1993-12-30Not AvailableUs
Neurontincapsule300 mgoralParke Davis Div Of Pfizer Inc1993-12-30Not AvailableUs
Neurontincapsule400 mgoralParke Davis Div Of Pfizer Inc1993-12-30Not AvailableUs
Neurontinsolution250 mg/5mLoralParke Davis Div Of Pfizer Inc2000-03-02Not AvailableUs
Gralisetablet, film coated300 mgoralDepomed, Inc.2011-01-28Not AvailableUs
Gralisetablet, film coated600 mgoralDepomed, Inc.2011-01-28Not AvailableUs
Gralise Starter PackkitDepomed, Inc.2011-01-28Not AvailableUs
Neurontincapsule400 mgoralSTAT Rx USA LLC1993-12-30Not AvailableUs
Neurontincapsule300 mgoralREMEDYREPACK INC.2012-09-17Not AvailableUs
Neurontincapsule300 mgoralCardinal Health1993-12-30Not AvailableUs
Gabapentintablet, film coated600 mgoralGreenstone LLC1998-10-09Not AvailableUs
Gabapentintablet, film coated800 mgoralGreenstone LLC1998-10-09Not AvailableUs
Gabapentinsuspension250 mg/5mLoralGreenstone LLC2011-03-29Not AvailableUs
Gabapentincapsule100 mgoralGreenstone LLC1993-12-30Not AvailableUs
Gabapentincapsule300 mgoralGreenstone LLC1993-12-30Not AvailableUs
Gabapentincapsule400 mgoralGreenstone LLC1993-12-30Not AvailableUs
Gralisetablet, film coated600 mgoralbryant ranch prepack2011-01-28Not AvailableUs
Generic Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Gabapentintablet600 mgoralTeva Pharmaceuticals USA Inc2008-07-11Not AvailableUs
Gabapentintablet800 mgoralTeva Pharmaceuticals USA Inc2008-08-01Not AvailableUs
Gabapentincapsule100 mgoralWest ward Pharmaceutical Corp2007-07-09Not AvailableUs
Gabapentincapsule300 mgoralWest ward Pharmaceutical Corp2007-07-09Not AvailableUs
Gabapentincapsule400 mgoralWest ward Pharmaceutical Corp2007-07-09Not AvailableUs
Gabapentincapsule100 mgoralWest ward Pharmaceutical Corp2007-07-09Not AvailableUs
Gabapentincapsule300 mgoralWest ward Pharmaceutical Corp2007-07-09Not AvailableUs
Gabapentincapsule400 mgoralWest ward Pharmaceutical Corp2007-07-09Not AvailableUs
Gabapentintablet, film coated600 mgoralActavis Elizabeth LLC2004-02-14Not AvailableUs
Gabapentintablet, film coated800 mgoralActavis Elizabeth LLC2004-02-14Not AvailableUs
Gabapentincapsule100 mgoralActavis Elizabeth LLC2004-10-04Not AvailableUs
Gabapentincapsule300 mgoralActavis Elizabeth LLC2004-10-04Not AvailableUs
Gabapentincapsule400 mgoralActavis Elizabeth LLC2004-10-04Not AvailableUs
Gabapentintablet600 mgoralMylan Pharmaceuticals Inc.2012-08-31Not AvailableUs
Gabapentintablet800 mgoralMylan Pharmaceuticals Inc.2012-08-31Not AvailableUs
Gabapentincapsule100 mgoralMylan Pharmaceuticals Inc.2011-02-14Not AvailableUs
Gabapentincapsule300 mgoralMylan Pharmaceuticals Inc.2011-02-14Not AvailableUs
Gabapentincapsule400 mgoralMylan Pharmaceuticals Inc.2011-02-14Not AvailableUs
Gabapentincapsule300 mgoralLiberty Pharmaceuticals, Inc.2009-11-24Not AvailableUs
Gabapentincapsule100 mgoralNcs Health Care Of Ky, Inc Dba Vangard Labs2003-09-12Not AvailableUs
Gabapentincapsule400 mgoralNcs Health Care Of Ky, Inc Dba Vangard Labs2003-09-12Not AvailableUs
Gabapentincapsule300 mgoralNcs Health Care Of Ky, Inc Dba Vangard Labs2003-09-12Not AvailableUs
Gabapentintablet, film coated600 mgoralNcs Health Care Of Ky, Inc Dba Vangard Labs2004-10-21Not AvailableUs
Gabapentintablet, film coated800 mgoralNcs Health Care Of Ky, Inc Dba Vangard Labs2004-10-21Not AvailableUs
Gabapentincapsule300 mgoralNcs Health Care Of Ky, Inc Dba Vangard Labs2010-01-23Not AvailableUs
Gabapentincapsule400 mgoralNcs Health Care Of Ky, Inc Dba Vangard Labs2014-03-17Not AvailableUs
Gabapentincapsule100 mgoralNcs Health Care Of Ky, Inc Dba Vangard Labs2014-03-17Not AvailableUs
Gabapentincapsule300 mgoralNcs Health Care Of Ky, Inc Dba Vangard Labs2010-01-23Not AvailableUs
Gabapentincapsule100 mgoralMajor Pharmaceuticals2005-04-06Not AvailableUs
Gabapentincapsule300 mgoralMajor Pharmaceuticals2005-04-06Not AvailableUs
Gabapentincapsule400 mgoralMajor Pharmaceuticals2005-04-06Not AvailableUs
Gabapentincapsule100 mgoralMajor Pharmaceuticals2010-05-10Not AvailableUs
Gabapentincapsule300 mgoralMajor Pharmaceuticals2010-05-10Not AvailableUs
Gabapentincapsule400 mgoralMajor Pharmaceuticals2010-05-10Not AvailableUs
Gabapentincapsule300 mgoralBlenheim Pharmacal, Inc.2010-08-20Not AvailableUs
Gabapentincapsule100 mgoralBlenheim Pharmacal, Inc.2010-10-08Not AvailableUs
Gabapentincapsule300 mgoralBlenheim Pharmacal, Inc.2010-01-04Not AvailableUs
Gabapentincapsule300 mgoralBlenheim Pharmacal, Inc.2014-04-04Not AvailableUs
Gabapentintablet600 mgoralBlenheim Pharmacal, Inc.2014-01-22Not AvailableUs
Gabapentincapsule400 mgoralBlenheim Pharmacal, Inc.2014-04-04Not AvailableUs
Gabapentintablet800 mgoralBlenheim Pharmacal, Inc.2014-01-22Not AvailableUs
Gabapentincapsule100 mgoralActavis Pharma Manufacturing Pvt Ltd. (SOD)2010-01-23Not AvailableUs
Gabapentincapsule300 mgoralActavis Pharma Manufacturing Pvt Ltd. (SOD)2010-01-23Not AvailableUs
Gabapentincapsule400 mgoralActavis Pharma Manufacturing Pvt Ltd. (SOD)2010-01-23Not AvailableUs
Gabapentincapsule100 mgoralSTAT Rx USA LLC2004-10-04Not AvailableUs
Gabapentincapsule300 mgoralSTAT Rx USA LLC2004-10-04Not AvailableUs
Gabapentintablet, film coated600 mgoralSTAT Rx USA LLC2004-02-14Not AvailableUs
Gabapentintablet, film coated800 mgoralSTAT Rx USA LLC2006-08-24Not AvailableUs
Gabapentincapsule400 mgoralSTAT Rx USA LLC2009-11-24Not AvailableUs
Gabapentintablet, film coated600 mgoralNorth Star Rx Llc2011-10-06Not AvailableUs
Gabapentintablet, film coated800 mgoralNorth Star Rx Llc2011-10-06Not AvailableUs
Gabapentincapsule100 mgoralNorth Star Rx Llc2008-01-31Not AvailableUs
Gabapentincapsule300 mgoralNorth Star Rx Llc2008-01-31Not AvailableUs
Gabapentincapsule400 mgoralNorth Star Rx Llc2008-01-31Not AvailableUs
Gabapentincapsule100 mgoralRebel Distributors Corp.2009-09-24Not AvailableUs
Gabapentincapsule300 mgoralRebel Distributors Corp.2006-08-29Not AvailableUs
Gabapentintablet, film coated600 mgoralRebel Distributors Corp.2006-08-24Not AvailableUs
Gabapentintablet, film coated800 mgoralRebel Distributors Corp.2006-08-24Not AvailableUs
Gabapentincapsule400 mgoralRebel Distributors Corp.2008-11-07Not AvailableUs
Gabapentincapsule100 mgoralMARKSANS PHARMA LIMITED2011-02-28Not AvailableUs
Gabapentincapsule300 mgoralMARKSANS PHARMA LIMITED2011-02-28Not AvailableUs
Gabapentincapsule400 mgoralMARKSANS PHARMA LIMITED2011-02-28Not AvailableUs
Gabapentincapsule100 mgoralCamber Pharmaceuticals Inc.2010-05-17Not AvailableUs
Gabapentincapsule300 mgoralCamber Pharmaceuticals Inc.2010-05-17Not AvailableUs
Gabapentincapsule400 mgoralCamber Pharmaceuticals Inc.2010-05-17Not AvailableUs
Gabapentintablet600 mgoralCamber Pharmaceuticals2012-10-29Not AvailableUs
Gabapentintablet800 mgoralCamber Pharmaceuticals2012-10-29Not AvailableUs
Gabapentincapsule100 mgoralAidarex Pharmaceuticals LLC2009-11-24Not AvailableUs
Gabapentincapsule300 mgoralAidarex Pharmaceuticals LLC2009-11-24Not AvailableUs
Gabapentincapsule400 mgoralAidarex Pharmaceuticals LLC2009-11-24Not AvailableUs
Gabapentintablet, film coated600 mgoralAidarex Pharmaceuticals LLC2011-10-06Not AvailableUs
Gabapentintablet, film coated800 mgoralAidarex Pharmaceuticals LLC2011-10-06Not AvailableUs
Gabapentincapsule300 mgoralRx Change Co.2014-10-26Not AvailableUs
Gabapentincapsule600 mgoralRx Change Co.2014-11-09Not AvailableUs
Gabapentincapsule300 mgoralLake Erie Medical & Surgical Supply DBA Quality Care Products LLC2009-11-24Not AvailableUs
Gabapentincapsule100 mgoralLake Erie Medical & Surgical Supply DBA Quality Care Products LLC2010-05-17Not AvailableUs
Gabapentincapsule400 mgoralLake Erie Medical & Surgical Supply DBA Quality Care Products LLC2010-05-17Not AvailableUs
Gabapentintablet600 mgoralLake Erie Medical DBA Quality Care Products LLC2008-07-11Not AvailableUs
Gabapentincapsule400 mgoralLake Erie Medical DBA Quality Care Products LLC2006-08-24Not AvailableUs
Gabapentinsolution250 mg/5mLoralAcella Pharmaceuticals, LLC2012-10-01Not AvailableUs
Gabapentincapsule300 mgoralRebel Distributors Corp2010-05-17Not AvailableUs
Gabapentintablet600 mgoralRebel Distributors Corp2011-02-09Not AvailableUs
Gabapentincapsule100 mgoralRebel Distributors Corp2009-11-24Not AvailableUs
Gabapentintablet800 mgoralRebel Distributors Corp2011-02-09Not AvailableUs
Gabapentincapsule400 mgoralRebel Distributors Corp2009-11-24Not AvailableUs
Gabapentincapsule100 mgoralAv Kare, Inc.2012-05-04Not AvailableUs
Gabapentincapsule300 mgoralAv Kare, Inc.2012-05-04Not AvailableUs
Gabapentincapsule400 mgoralAv Kare, Inc.2012-05-04Not AvailableUs
Gabapentincapsule300 mgoralWestwood Manufacturing2010-01-23Not AvailableUs
Gabapentincapsule100 mgoralSTAT Rx USA LLC2009-11-24Not AvailableUs
Gabapentincapsule300 mgoralSTAT Rx USA LLC2009-11-24Not AvailableUs
Gabapentintablet600 mgoralSTAT Rx USA LLC2009-06-09Not AvailableUs
Gabapentincapsule400 mgoralPd Rx Pharmaceuticals, Inc.2004-10-04Not AvailableUs
Gabapentintablet, film coated800 mgoralPd Rx Pharmaceuticals, Inc.2004-02-14Not AvailableUs
Gabapentincapsule300 mgoralPd Rx Pharmaceuticals, Inc.2009-11-24Not AvailableUs
Gabapentincapsule100 mgoralPd Rx Pharmaceuticals, Inc.2009-11-24Not AvailableUs
Gabapentincapsule300 mgoralAphena Pharma Solutions Tennessee, Inc.2010-05-17Not AvailableUs
Gabapentincapsule400 mgoralAphena Pharma Solutions Tennessee, Inc.2010-05-17Not AvailableUs
Gabapentincapsule100 mgoralAphena Pharma Solutions Tennessee, Inc.2010-05-17Not AvailableUs
Gabapentincapsule100 mgoralAphena Pharma Solutions Tennessee, Llc2008-01-31Not AvailableUs
Gabapentincapsule300 mgoralAphena Pharma Solutions Tennessee, Llc2008-01-31Not AvailableUs
Gabapentincapsule400 mgoralAphena Pharma Solutions Tennessee, Llc2008-01-31Not AvailableUs
Gabapentintablet, film coated600 mgoralAphena Pharma Solutions Tennessee, Llc2012-11-02Not AvailableUs
Gabapentincapsule100 mgoralSolco healthcare U.S., LLC2012-10-15Not AvailableUs
Gabapentincapsule300 mgoralSolco healthcare U.S., LLC2012-10-15Not AvailableUs
Gabapentincapsule400 mgoralSolco healthcare U.S., LLC2012-10-15Not AvailableUs
Gabapentintablet, film coated600 mgoralSolco healthcare U.S., LLC2014-11-01Not AvailableUs
Gabapentintablet, film coated800 mgoralSolco healthcare U.S., LLC2014-11-01Not AvailableUs
Gabapentincapsule300 mgoralPharmaceutica North America, Inc.2012-08-09Not AvailableUs
Gabapentin KitkitPharmaceutica North America, Inc.2012-08-28Not AvailableUs
Gabapentincapsule300 mgoralPharmaceutica North America, Inc.2014-02-12Not AvailableUs
Gabapentincapsule300 mgoralMedsource Pharmaceuticals2009-11-24Not AvailableUs
Gabapentincapsule100 mgoralActavis Inc.2014-03-17Not AvailableUs
Gabapentincapsule300 mgoralActavis Inc.2010-01-23Not AvailableUs
Gabapentincapsule400 mgoralActavis Inc.2014-03-17Not AvailableUs
Gabapentincapsule300 mgoralSafecor Health, LLC2014-09-30Not AvailableUs
Gabapentincapsule100 mgoralSafecor Health, LLC2014-09-30Not AvailableUs
Gabapentincapsule400 mgoralSafecor Health, LLC2014-09-30Not AvailableUs
Gabapentincapsule100 mgoralREMEDYREPACK INC.2011-04-19Not AvailableUs
Gabapentincapsule100 mgoralREMEDYREPACK INC.2011-03-01Not AvailableUs
Gabapentintablet800 mgoralREMEDYREPACK INC.2011-09-14Not AvailableUs
Gabapentintablet800 mgoralREMEDYREPACK INC.2011-05-25Not AvailableUs
Gabapentincapsule400 mgoralREMEDYREPACK INC.2011-03-31Not AvailableUs
Gabapentintablet600 mgoralREMEDYREPACK INC.2011-06-07Not AvailableUs
Gabapentintablet600 mgoralREMEDYREPACK INC.2011-06-27Not AvailableUs
Gabapentintablet600 mgoralREMEDYREPACK INC.2011-07-08Not AvailableUs
Gabapentintablet600 mgoralREMEDYREPACK INC.2011-07-11Not AvailableUs
Gabapentincapsule300 mgoralREMEDYREPACK INC.2011-07-19Not AvailableUs
Gabapentincapsule300 mgoralREMEDYREPACK INC.2011-07-25Not AvailableUs
Gabapentintablet800 mgoralREMEDYREPACK INC.2011-07-28Not AvailableUs
Gabapentintablet800 mgoralREMEDYREPACK INC.2011-09-23Not AvailableUs
Gabapentincapsule100 mgoralREMEDYREPACK INC.2011-05-19Not AvailableUs
Gabapentintablet600 mgoralREMEDYREPACK INC.2011-09-09Not AvailableUs
Gabapentintablet800 mgoralREMEDYREPACK INC.2011-12-02Not AvailableUs
Gabapentintablet600 mgoralREMEDYREPACK INC.2012-03-07Not AvailableUs
Gabapentincapsule300 mgoralREMEDYREPACK INC.2013-05-01Not AvailableUs
Gabapentincapsule300 mgoralREMEDYREPACK INC.2013-10-15Not AvailableUs
Gabapentincapsule300 mgoralREMEDYREPACK INC.2012-03-16Not AvailableUs
Gabapentincapsule100 mgoralREMEDYREPACK INC.2012-03-22Not AvailableUs
Gabapentincapsule100 mgoralREMEDYREPACK INC.2013-05-21Not AvailableUs
Gabapentincapsule300 mgoralREMEDYREPACK INC.2013-05-20Not AvailableUs
Gabapentincapsule300 mgoralREMEDYREPACK INC.2012-03-23Not AvailableUs
Gabapentincapsule400 mgoralREMEDYREPACK INC.2013-02-15Not AvailableUs
Gabapentincapsule100 mgoralREMEDYREPACK INC.2013-02-08Not AvailableUs
Gabapentincapsule300 mgoralLake Erie Medical DBA Quality Care Products LLC2010-09-17Not AvailableUs
Gabapentincapsule400 mgoralLake Erie Medical & Surgical Supply DBA Quality Care Products LLC2010-11-04Not AvailableUs
Gabapentincapsule100 mgoralLake Erie Medical DBA Quality Care Products LLC2011-11-05Not AvailableUs
Gabapentintablet600 mgoralLake Erie Medica & Surgical Supply DBA Quality Care Products LLC2011-11-04Not AvailableUs
Gabapentintablet, film coated800 mgoralLake Erie Medical & Surgical S6758upply DBA Quality Care Products LLC2010-12-06Not AvailableUs
Gabapentincapsule100 mgoralAv Pak2014-09-15Not AvailableUs
Gabapentincapsule300 mgoralAv Pak2014-09-15Not AvailableUs
Gabapentincapsule400 mgoralAv Pak2014-09-15Not AvailableUs
Gabapentintablet, film coated600 mgoralAv Pak2015-02-13Not AvailableUs
Gabapentintablet, film coated800 mgoralAv Pak2015-02-13Not AvailableUs
Gabapentinsolution250 mg/5mLoralHi Tech Pharmacal Co., Inc.2011-02-23Not AvailableUs
Gabapentincapsule100 mgoralUnit Dose Services2010-05-17Not AvailableUs
Gabapentintablet, film coated600 mgoralUnit Dose Services2006-08-24Not AvailableUs
Gabapentincapsule100 mgoralUnit Dose Services2009-11-24Not AvailableUs
Gabapentincapsule300 mgoralUnit Dose Services2010-05-17Not AvailableUs
Gabapentintablet800 mgoralUnit Dose Services2008-08-01Not AvailableUs
Gabapentincapsule300 mgoralNorthwind Pharmaceuticals2014-12-23Not AvailableUs
Gabapentinsolution250 mg/5mLoralTaro Pharmaceuticals U.S.A., Inc.2013-07-03Not AvailableUs
Gabapentincapsule100 mgoralBreckenridge Pharmaceutical, Inc.2012-10-15Not AvailableUs
Gabapentincapsule300 mgoralBreckenridge Pharmaceutical, Inc.2012-10-15Not AvailableUs
Gabapentincapsule400 mgoralBreckenridge Pharmaceutical, Inc.2012-10-15Not AvailableUs
Gabapentincapsule100 mgoralREMEDYREPACK INC.2012-09-20Not AvailableUs
Gabapentincapsule100 mgoralREMEDYREPACK INC.2013-05-15Not AvailableUs
Gabapentincapsule100 mgoralREMEDYREPACK INC.2013-05-22Not AvailableUs
Gabapentintablet, film coated800 mgoralREMEDYREPACK INC.2014-01-09Not AvailableUs
Gabapentintablet600 mgoralREMEDYREPACK INC.2014-01-30Not AvailableUs
Gabapentincapsule100 mgoralREMEDYREPACK INC.2014-02-18Not AvailableUs
Gabapentincapsule300 mgoralREMEDYREPACK INC.2014-03-04Not AvailableUs
Gabapentincapsule100 mgoralREMEDYREPACK INC.2014-03-04Not AvailableUs
Gabapentincapsule300 mgoralREMEDYREPACK INC.2014-05-22Not AvailableUs
Gabapentintablet800 mgoralREMEDYREPACK INC.2014-07-07Not AvailableUs
Gabapentincapsule100 mgoralGen Source Rx2008-01-31Not AvailableUs
Gabapentincapsule300 mgoralGen Source Rx2008-01-31Not AvailableUs
Gabapentincapsule400 mgoralGen Source Rx2008-01-31Not AvailableUs
Gabapentincapsule100 mgoralH.J. Harkins Company, Inc.2010-05-17Not AvailableUs
Gabapentintablet800 mgoralH.J. Harkins Company, Inc.2006-04-01Not AvailableUs
Gabapentintablet600 mgoralH.J. Harkins Company, Inc.2006-04-01Not AvailableUs
Gabapentincapsule100 mgoralAmneal Pharmaceuticals of New York, LLC2009-11-24Not AvailableUs
Gabapentincapsule300 mgoralAmneal Pharmaceuticals of New York, LLC2009-11-24Not AvailableUs
Gabapentincapsule400 mgoralAmneal Pharmaceuticals of New York, LLC2009-11-24Not AvailableUs
Gabapentincapsule300 mgoralPhysicians Total Care, Inc.2006-08-29Not AvailableUs
Gabapentintablet800 mgoralPhysicians Total Care, Inc.2004-12-16Not AvailableUs
Gabapentintablet600 mgoralPhysicians Total Care, Inc.2005-02-14Not AvailableUs
Gabapentincapsule100 mgoralPhysicians Total Care, Inc.2009-09-24Not AvailableUs
Gabapentincapsule400 mgoralPhysicians Total Care, Inc.2008-11-07Not AvailableUs
Gabapentincapsule300 mgoralCardinal Health2005-04-06Not AvailableUs
Gabapentincapsule100 mgoralCardinal Health2010-05-10Not AvailableUs
Gabapentincapsule300 mgoralCardinal Health2010-05-10Not AvailableUs
Gabapentincapsule400 mgoralCardinal Health2010-05-10Not AvailableUs
Gabapentincapsule400 mgoralCardinal Health2007-06-20Not AvailableUs
Gabapentincapsule300 mgoralCardinal Health2007-06-20Not AvailableUs
Gabapentincapsule100 mgoralCardinal Health2004-12-10Not AvailableUs
Gabapentintablet600 mgoralCardinal Health2007-08-02Not AvailableUs
Gabapentincapsule400 mgoralCardinal Health2004-12-10Not AvailableUs
Gabapentincapsule100 mgoralCardinal Health2011-01-29Not AvailableUs
Gabapentincapsule100 mgoralCardinal Health2010-01-23Not AvailableUs
Gabapentincapsule300 mgoralCardinal Health2010-01-23Not AvailableUs
Gabapentincapsule400 mgoralCardinal Health2010-01-23Not AvailableUs
Gabapentintablet, film coated600 mgoralCardinal Health2012-08-31Not AvailableUs
Gabapentincapsule400 mgoralCardinal Health2012-03-05Not AvailableUs
Gabapentincapsule100 mgoralCardinal Health2012-03-05Not AvailableUs
Gabapentintablet, film coated600 mgoralCardinal Health2004-02-14Not AvailableUs
Gabapentincapsule100 mgoralCardinal Health2004-04-28Not AvailableUs
Gabapentincapsule300 mgoralCardinal Health2011-04-01Not AvailableUs
Gabapentincapsule400 mgoralCardinal Health2005-04-06Not AvailableUs
Gabapentincapsule100 mgoralCardinal Health2005-04-06Not AvailableUs
Gabapentincapsule400 mgoralCardinal Health2009-11-24Not AvailableUs
Gabapentincapsule300 mgoralCardinal Health2009-11-24Not AvailableUs
Gabapentincapsule300 mgoralPd Rx Pharmaceuticals, Inc.2010-05-17Not AvailableUs
Gabapentincapsule100 mgoralPd Rx Pharmaceuticals, Inc.2004-10-04Not AvailableUs
Gabapentintablet600 mgoralPd Rx Pharmaceuticals, Inc.2006-04-01Not AvailableUs
Gabapentintablet800 mgoralLake Erie Medical DBA Quality Care Products LLC2008-08-01Not AvailableUs
Gabapentincapsule100 mgoralClinical Solutions Wholesale2009-11-24Not AvailableUs
Gabapentintablet, film coated600 mgoralClinical Solutions Wholesale2006-08-24Not AvailableUs
Gabapentintablet, film coated600 mgoralClinical Solutions Wholesale2006-08-24Not AvailableUs
Gabapentincapsule300 mgoralClinical Solutions Wholesale2011-01-29Not AvailableUs
Gabapentincapsule300 mgoralClinical Solutions Wholesale2011-01-29Not AvailableUs
Gabapentincapsule300 mgoralNew Horizon Rx Group, LLC2013-08-25Not AvailableUs
Gabapentinsolution250 mg/5mLoralKiel Laboratories, Inc.2012-05-01Not AvailableUs
Gabapentincapsule100 mgoralHikma Pharmaceutical2007-07-09Not AvailableUs
Gabapentincapsule300 mgoralHikma Pharmaceutical2007-07-09Not AvailableUs
Gabapentincapsule400 mgoralHikma Pharmaceutical2007-07-09Not AvailableUs
Gabapentintablet, film coated800 mgoralHikma Pharmaceutical2011-07-21Not AvailableUs
Gabapentintablet, film coated600 mg/1001oralHikma Pharmaceutical2011-07-21Not AvailableUs
Gabapentincapsule100 mgoralGolden State Medical Supply, Inc.2013-03-08Not AvailableUs
Gabapentincapsule300 mgoralGolden State Medical Supply, Inc.2013-03-08Not AvailableUs
Gabapentincapsule400 mgoralGolden State Medical Supply, Inc.2013-03-08Not AvailableUs
Gabapentincapsule100 mgoralGolden State Medical Supply, Inc.2010-05-17Not AvailableUs
Gabapentincapsule300 mgoralGolden State Medical Supply, Inc.2010-05-17Not AvailableUs
Gabapentincapsule400 mgoralGolden State Medical Supply, Inc.2010-05-17Not AvailableUs
Gabapentintablet, film coated600 mgoralGolden State Medical Supply, Inc.2006-09-15Not AvailableUs
Gabapentintablet, film coated600 mgoralGolden State Medical Supply, Inc.2006-09-15Not AvailableUs
Gabapentincapsule100 mgoralApotex Corp.2005-04-06Not AvailableUs
Gabapentincapsule300 mgoralApotex Corp.2005-04-06Not AvailableUs
Gabapentincapsule400 mgoralApotex Corp.2005-04-06Not AvailableUs
Gabapentintablet, film coated600 mgoralApotex Corp.2006-09-15Not AvailableUs
Gabapentintablet, film coated600 mgoralApotex Corp.2006-09-15Not AvailableUs
Gabapentincapsule400 mgoralSt Marys Medical Park Pharmacy2010-12-01Not AvailableUs
Gabapentintablet, film coated800 mgoralSt Marys Medical Park Pharmacy2010-12-03Not AvailableUs
Gabapentincapsule400 mgoralDIRECT RX2014-01-01Not AvailableUs
Gabapentincapsule100 mgoralDIRECT RX2014-01-01Not AvailableUs
Gabapentincapsule300 mgoralDIRECT RX2014-01-01Not AvailableUs
Gabapentintablet600 1oralDIRECT RX2014-01-01Not AvailableUs
Gabapentintablet, film coated800 mgoralDIRECT RX2014-01-01Not AvailableUs
Gabapentincapsule400 mgoralDIRECT RX2014-01-01Not AvailableUs
Gabapentincapsule300 mgoralDIRECT RX2014-01-01Not AvailableUs
Gabapentincapsule100 mgoralSun Pharmaceutical Industries Limited2006-08-24Not AvailableUs
Gabapentincapsule300 mgoralSun Pharmaceutical Industries Limited2006-08-24Not AvailableUs
Gabapentincapsule400 mgoralSun Pharmaceutical Industries Limited2006-08-24Not AvailableUs
Gabapentintablet, film coated600 mgoralSun Pharmaceutical Industries Limited2006-08-24Not AvailableUs
Gabapentintablet, film coated800 mgoralSun Pharmaceutical Industries Limited2006-08-24Not AvailableUs
Gabapentintablet, film coated600 mgoralProficient Rx2004-02-14Not AvailableUs
Gabapentintablet800 mgoralProficient Rx LP2006-04-01Not AvailableUs
Gabapentincapsule300 mgoralProficient Rx LP2010-05-17Not AvailableUs
Gabapentincapsule400 mgoralProficient Rx LP2010-05-17Not AvailableUs
Gabapentintablet, film coated800 mgoralProficient Rx LP2011-10-06Not AvailableUs
Gabapentintablet600 mgoralProficient Rx LP2012-10-29Not AvailableUs
Gabapentincapsule100 mgoralProficient Rx LP2010-05-17Not AvailableUs
Gabapentincapsule100 mgoralRanbaxy Pharmaceuticals Inc.2005-11-02Not AvailableUs
Gabapentincapsule300 mgoralRanbaxy Pharmaceuticals Inc.2005-11-02Not AvailableUs
Gabapentincapsule400 mgoralRanbaxy Pharmaceuticals Inc.2005-11-02Not AvailableUs
Gabapentincapsule100 mgoralbryant ranch prepack2009-11-24Not AvailableUs
Gabapentincapsule400 mgoralbryant ranch prepack2010-05-17Not AvailableUs
Gabapentincapsule300 mgoralbryant ranch prepack2010-05-17Not AvailableUs
Gabapentintablet600 mgoralbryant ranch prepack2006-04-01Not AvailableUs
Gabapentintablet, film coated800 mgoralbryant ranch prepack2006-08-24Not AvailableUs
Gabapentincapsule100 mgoralMc Kesson Packaging Services A Business Unit Of Mc Kesson Corporation2004-10-04Not AvailableUs
Gabapentincapsule300 mgoralMc Kesson Packaging Services A Business Unit Of Mc Kesson Corporation2004-10-04Not AvailableUs
Gabapentincapsule400 mgoralMc Kesson Packaging Services A Business Unit Of Mc Kesson Corporation2004-10-04Not AvailableUs
Gabapentintablet, film coated600 mgoralMc Kesson Packaging Services A Business Unit Of Mc Kesson Corporation2004-02-14Not AvailableUs
Gabapentincapsule100 mgoralMc Kesson Packaging Services A Business Unit Of Mc Kesson Corporation2009-11-24Not AvailableUs
Gabapentincapsule300 mgoralMc Kesson Packaging Services A Business Unit Of Mc Kesson Corporation2009-11-24Not AvailableUs
Gabapentincapsule400 mgoralMc Kesson Packaging Services A Business Unit Of Mc Kesson Corporation2009-11-24Not AvailableUs
Gabapentincapsule300 mgoralMc Kesson Packaging Services A Business Unit Of Mc Kesson Corporation2012-10-29Not AvailableUs
Gabapentincapsule300 mgoralReady Meds2010-05-17Not AvailableUs
Gabapentintablet600 mgoralTYA Pharmaceuticals2006-04-01Not AvailableUs
Gabapentincapsule300 mgoralTYA Pharmaceuticals2006-08-24Not AvailableUs
Gabapentincapsule100 mgoralTYA Pharmaceuticals2010-05-17Not AvailableUs
Gabapentincapsule300 mgoralTYA Pharmaceuticals2010-05-17Not AvailableUs
Gabapentincapsule100 mgoralTYA Pharmaceuticals2010-01-23Not AvailableUs
Gabapentincapsule100 mgoralAmneal Pharmaceuticals of New York, LLC2009-11-24Not AvailableUs
Gabapentincapsule300 mgoralAmneal Pharmaceuticals of New York, LLC2009-11-24Not AvailableUs
Gabapentincapsule400 mgoralAmneal Pharmaceuticals of New York, LLC2009-11-24Not AvailableUs
Gabapentinsolution250 mg/5mLoralAmneal Pharmaceuticals of New York, LLC2011-09-30Not AvailableUs
Gabapentintablet, film coated600 mgoralCadila Healthcare Limited2012-10-16Not AvailableUs
Gabapentintablet, film coated800 mgoralCadila Healthcare Limited2012-10-16Not AvailableUs
Gabapentincapsule100 mgoralAurobindo Pharma Limited2008-01-31Not AvailableUs
Gabapentincapsule300 mgoralAurobindo Pharma Limited2008-01-31Not AvailableUs
Gabapentincapsule400 mgoralAurobindo Pharma Limited2008-01-31Not AvailableUs
Gabapentintablet, film coated600 mgoralAurobindo Pharma Limited2011-10-06Not AvailableUs
Gabapentintablet, film coated800 mgoralAurobindo Pharma Limited2011-10-06Not AvailableUs
Gabapentincapsule300 mgoralMed Vantx, Inc.2004-10-04Not AvailableUs
Gabapentincapsule300 mgoralMed Vantx, Inc.2008-01-31Not AvailableUs
Gabapentincapsule300 mgoralMed Vantx Inc.2011-09-13Not AvailableUs
Gabapentincapsule300 mgoralDispensing Solutions, Inc.2007-07-09Not AvailableUs
Gabapentincapsule100 mgoralDispensing Solutions, Inc.2007-07-09Not AvailableUs
Gabapentincapsule400 mgoralContract Pharmacy Services Pa2010-07-19Not AvailableUs
Gabapentincapsule300 mgoralContract Pharmacy Services Pa2010-04-12Not AvailableUs
Gabapentintablet600 mgoralContract Pharmacy Services Pa2009-08-30Not AvailableUs
Gabapentincapsule300 mgoralAphena Pharma Solutions Tennessee, Llc2004-10-04Not AvailableUs
Gabapentincapsule400 mgoralAphena Pharma Solutions Tennessee, Llc2004-10-04Not AvailableUs
Gabapentincapsule100 mgoralAphena Pharma Solutions Tennessee, Llc2004-10-04Not AvailableUs
Gabapentincapsule100 mgoralAscend Laboratories, LLC2011-01-29Not AvailableUs
Gabapentincapsule300 mgoralAscend Laboratories, LLC2011-01-29Not AvailableUs
Gabapentincapsule400 mgoralAscend Laboratories, LLC2011-01-29Not AvailableUs
Gabapentintablet, film coated600 mgoralBlue Point Laboratories2013-07-24Not AvailableUs
Gabapentintablet, film coated800 mgoralBlue Point Laboratories2013-07-24Not AvailableUs
Gabapentincapsule100 mgoralAMERISOURCEBERGEN DRUG CORPORATION2004-12-10Not AvailableUs
Gabapentincapsule400 mgoralAMERISOURCEBERGEN DRUG CORPORATION2004-12-10Not AvailableUs
Gabapentintablet600 mgoralAmerican Health Packaging2007-08-02Not AvailableUs
Gabapentintablet800 mgoralAmerican Health Packaging2007-08-13Not AvailableUs
Gabapentincapsule300 mgoralAmerican Health Packaging2011-04-012015-09-30Us
Gabapentincapsule100 mgoralAmerican Health Packaging2012-03-052015-07-31Us
Gabapentincapsule400 mgoralAmerican Health Packaging2012-03-052015-07-31Us
Gabapentintablet, film coated600 mgoralAmerican Health Packaging2012-08-31Not AvailableUs
Gabapentintablet, film coated800 mgoralAmerican Health Packaging2012-08-31Not AvailableUs
Gabapentincapsule300 mgoralAmerican Health Packaging2014-07-01Not AvailableUs
Gabapentincapsule400 mgoralAmerican Health Packaging2014-07-01Not AvailableUs
Gabapentincapsule100 mgoralAmerican Health Packaging2014-07-01Not AvailableUs
Gabapentintablet, film coated600 mgoralAmerican Health Packaging2014-11-03Not AvailableUs
Gabapentintablet, film coated800 mgoralAmerican Health Packaging2014-09-01Not AvailableUs
Gabapentintablet, film coated600 mgoralZydus Pharmaceuticals (USA) Inc.2012-10-16Not AvailableUs
Gabapentintablet, film coated800 mgoralZydus Pharmaceuticals (USA) Inc.2012-10-16Not AvailableUs
Gabapentincapsule400 mgoralKeltman Pharmaceuticals Inc.2009-12-15Not AvailableUs
Gabapentincapsule300 mgoralKeltman Pharmaceuticals Inc.2009-12-15Not AvailableUs
Gabapentincapsule100 mgoralKeltman Pharmaceuticals Inc.2009-12-15Not AvailableUs
Gabapentintablet600 mgoralGlenmark Generics Inc., USA2006-04-01Not AvailableUs
Gabapentintablet800 mgoralGlenmark Generics Inc., USA2006-04-01Not AvailableUs
Gabapentintablet600 mgoralPreferred Pharmaceuticals, Inc.2006-04-01Not AvailableUs
Gabapentincapsule100 mgoralPreferred Pharmaceuticals, Inc.2010-05-17Not AvailableUs
Gabapentincapsule300 mgoralPreferred Pharmaceuticals, Inc.2010-05-17Not AvailableUs
Gabapentincapsule400 mgoralPreferred Pharmaceuticals, Inc.2014-02-28Not AvailableUs
Gabapentintablet, film coated600 mgoralPreferred Pharmaceuticals, Inc.2012-01-27Not AvailableUs
Gabapentincapsule100 mgoralMc Kesson Contract Packaging2011-08-29Not AvailableUs
Gabapentincapsule300 mgoralMc Kesson Contract Packaging2011-08-29Not AvailableUs
Gabapentincapsule400 mgoralMc Kesson Contract Packaging2011-12-09Not AvailableUs
Gabapentintablet, film coated600 mgoralMc Kesson Contract Packaging2011-11-09Not AvailableUs
Gabapentincapsule100 mgoralMc Kesson Contract Packaging2014-03-17Not AvailableUs
Gabapentintablet, film coated600 mgoralAllied Pharma Inc2013-06-02Not AvailableUs
Gabapentintablet, film coated800 mgoralAllied Pharma Inc2013-06-02Not AvailableUs
Gabapentincapsule100 mgoralExelan Pharmaceuticals, Inc.2010-04-26Not AvailableUs
Gabapentincapsule300 mgoralExelan Pharmaceuticals, Inc.2010-04-26Not AvailableUs
Gabapentincapsule400 mgoralExelan Pharmaceuticals, Inc.2010-04-26Not AvailableUs
Gabapentintablet, film coated600 mgoralExelan Pharmaceuticals Inc.2012-11-02Not AvailableUs
Gabapentintablet, film coated800 mgoralExelan Pharmaceuticals Inc.2012-11-02Not AvailableUs
Gabapentincapsule100 mgoralSivem Pharmaceuticals UlcNot AvailableNot AvailableCanada
Gabapentincapsule300 mgoralSivem Pharmaceuticals UlcNot AvailableNot AvailableCanada
Gabapentincapsule400 mgoralSivem Pharmaceuticals UlcNot AvailableNot AvailableCanada
Gabapentincapsule100 mgoralSanis Health IncNot AvailableNot AvailableCanada
Gabapentincapsule300 mgoralSanis Health IncNot AvailableNot AvailableCanada
Gabapentincapsule400 mgoralSanis Health IncNot AvailableNot AvailableCanada
Gabapentintablet600 mgoralSivem Pharmaceuticals UlcNot AvailableNot AvailableCanada
Gabapentintablet800 mgoralSivem Pharmaceuticals UlcNot AvailableNot AvailableCanada
Gabapentintablet600 mgoralSanis Health IncNot AvailableNot AvailableCanada
Gabapentintablet800 mgoralSanis Health IncNot AvailableNot AvailableCanada
Over the Counter ProductsNot Available
International Brands
NameCompany
AcloniumNot Available
Novo-GabapentinNot Available
Brand mixturesNot Available
SaltsNot Available
Categories
CAS number60142-96-3
WeightAverage: 171.2368
Monoisotopic: 171.125928793
Chemical FormulaC9H17NO2
InChI KeyUGJMXCAKCUNAIE-UHFFFAOYSA-N
InChI
InChI=1S/C9H17NO2/c10-7-9(6-8(11)12)4-2-1-3-5-9/h1-7,10H2,(H,11,12)
IUPAC Name
2-[1-(aminomethyl)cyclohexyl]acetic acid
SMILES
NCC1(CC(O)=O)CCCCC1
Mass SpecNot Available
Taxonomy
KingdomOrganic Compounds
SuperclassOrganic Acids and Derivatives
ClassCarboxylic Acids and Derivatives
SubclassAmino Acids, Peptides, and Analogues
Direct parentGamma Amino Acids and Derivatives
Alternative parentsPolyamines; Enolates; Carboxylic Acids; Monoalkylamines
Substituentscarboxylic acid; enolate; polyamine; primary amine; amine; primary aliphatic amine; organonitrogen compound
Classification descriptionThis compound belongs to the gamma amino acids and derivatives. These are amino acids having a (-NH2) group attached to the gamma carbon atom.
Pharmacology
IndicationFor the management of postherpetic neuralgia in adults and as adjunctive therapy in the treatment of partial seizures with and without secondary generalization in patients over 12 years of age with epilepsy.
PharmacodynamicsGabapentin, an analog of GABA, is used as an anticonvulsant to treat partial seizures, amyotrophic lateral sclerosis (ALS), and painful neuropathies. Potential uses include monotherapy of refractory partial seizure disorders, and treatment of spasticity in multiple sclerosis, tremor. mood disorders, and attenuation of disruptive behaviors in dementia. Gabapentin has high lipid solubility, is not metabolized by the liver, has no protein binding, and doesn't possess the usual drug interactions.
Mechanism of actionGabapentin interacts with cortical neurons at auxillary subunits of voltage-sensitive calcium channels. Gabapentin increases the synaptic concentration of GABA, enhances GABA responses at non-synaptic sites in neuronal tissues, and reduces the release of mono-amine neurotransmitters. One of the mechanisms implicated in this effect of gabapentin is the reduction of the axon excitability measured as an amplitude change of the presynaptic fibre volley (FV) in the CA1 area of the hippocampus. This is mediated through its binding to presynaptic NMDA receptors. Other studies have shown that the antihyperalgesic and antiallodynic effects of gabapentin are mediated by the descending noradrenergic system, resulting in the activation of spinal alpha2-adrenergic receptors. Gabapentin has also been shown to bind and activate the adenosine A1 receptor.
AbsorptionRapid. Absorbed in part by the L-amino acid transport system, which is a carrier-mediated, saturable transport system; as the dose increases, bioavailability decreases. Bioavailability ranges from approximately 60% for a 900 mg dose per day to approximately 27% for a 4800 milligram dose per day. Food has a slight effect on the rate and extent of absorption of gabapentin (14% increase in AUC).
Volume of distribution
  • 58±6 L
Protein bindingLess than 3% of gabapentin circulates bound to plasma protein.
Metabolism

All pharmacological actions following gabapentin administration are due to the activity of the parent compound; gabapentin is not appreciably metabolized in humans.

Route of eliminationGabapentin is eliminated from the systemic circulation by renal excretion as unchanged drug. Gabapentin is not appreciably metabolized in humans.
Half life5-7 hours
Clearance
  • 190 mL/min
ToxicitySymptoms of overdose include ataxia, labored breathing, ptosis, sedation, hypoactivity, and excitation.
Affected organisms
  • Humans and other mammals
PathwaysNot Available
SNP Mediated EffectsNot Available
SNP Mediated Adverse Drug ReactionsNot Available
ADMET
Predicted ADMET features
Property Value Probability
Human Intestinal Absorption + 0.941
Blood Brain Barrier + 0.9382
Caco-2 permeable - 0.7271
P-glycoprotein substrate Non-substrate 0.6557
P-glycoprotein inhibitor I Non-inhibitor 0.9789
P-glycoprotein inhibitor II Non-inhibitor 0.8866
Renal organic cation transporter Non-inhibitor 0.7982
CYP450 2C9 substrate Non-substrate 0.893
CYP450 2D6 substrate Non-substrate 0.8124
CYP450 3A4 substrate Non-substrate 0.7612
CYP450 1A2 substrate Non-inhibitor 0.9409
CYP450 2C9 substrate Non-inhibitor 0.9273
CYP450 2D6 substrate Non-inhibitor 0.9418
CYP450 2C19 substrate Non-inhibitor 0.9547
CYP450 3A4 substrate Non-inhibitor 0.8438
CYP450 inhibitory promiscuity Low CYP Inhibitory Promiscuity 0.9706
Ames test Non AMES toxic 0.9162
Carcinogenicity Non-carcinogens 0.8536
Biodegradation Not ready biodegradable 0.7046
Rat acute toxicity 1.6472 LD50, mol/kg Not applicable
hERG inhibition (predictor I) Weak inhibitor 0.9406
hERG inhibition (predictor II) Non-inhibitor 0.8659
Pharmacoeconomics
Manufacturers
  • Actavis elizabeth llc
  • Amneal pharmaceuticals ny llc
  • Apotex inc etobicoke site
  • Aurobindo pharma usa inc
  • Hikma pharmaceuticals
  • Invagen pharmaceuticals inc
  • Ivax pharmaceuticals inc sub teva pharmaceuticals usa
  • Mutual pharmaceutical co inc
  • Ranbaxy laboratories ltd
  • Sandoz inc
  • Sun pharmaceutical industries ltd
  • Teva pharmaceuticals usa
  • Watson laboratories inc
  • Pfizer pharmaceuticals ltd
  • Parke davis div warner lambert co
  • Glenmark generics ltd
  • Matrix laboratories ltd
  • Teva pharmaceuticals usa inc
Packagers
Dosage forms
FormRouteStrength
Capsuleoral100 mg
Capsuleoral300 mg
Capsuleoral400 mg
Capsuleoral600 mg
Kit
Solutionoral250 mg/5mL
Suspensionoral250 mg/5mL
Tabletoral600 1
Tabletoral600 mg
Tabletoral800 mg
Tablet, film coatedoral300 mg
Tablet, film coatedoral600 mg
Tablet, film coatedoral600 mg/1001
Tablet, film coatedoral800 mg
Prices
Unit descriptionCostUnit
Gabapentin powder30.0USDg
Neurontin 800 mg tablet4.73USDtablet
Neurontin 600 mg tablet3.94USDtablet
Gabapentin 800 mg tablet3.09USDtablet
Gabapentin 600 mg tablet2.58USDtablet
Neurontin 400 mg Capsule1.97USDcapsule
Neurontin 300 mg Capsule1.67USDcapsule
Gabapentin 400 mg tablet1.59USDtablet
Gabapentin 300 mg tablet1.32USDtablet
Gabapentin 400 mg Capsule1.21USDcapsule
Gabapentin 300 mg Capsule1.02USDcapsule
Apo-Gabapentin 400 mg Capsule0.76USDcapsule
Co Gabapentin 400 mg Capsule0.76USDcapsule
Mylan-Gabapentin 400 mg Capsule0.76USDcapsule
Novo-Gabapentin 400 mg Capsule0.76USDcapsule
Phl-Gabapentin 400 mg Capsule0.76USDcapsule
Pms-Gabapentin 400 mg Capsule0.76USDcapsule
Ran-Gabapentin 400 mg Capsule0.76USDcapsule
Ratio-Gabapentin 400 mg Capsule0.76USDcapsule
Neurontin 100 mg Capsule0.65USDcapsule
Apo-Gabapentin 300 mg Capsule0.64USDcapsule
Co Gabapentin 300 mg Capsule0.64USDcapsule
Mylan-Gabapentin 300 mg Capsule0.64USDcapsule
Novo-Gabapentin 300 mg Capsule0.64USDcapsule
Phl-Gabapentin 300 mg Capsule0.64USDcapsule
Pms-Gabapentin 300 mg Capsule0.64USDcapsule
Ran-Gabapentin 300 mg Capsule0.64USDcapsule
Ratio-Gabapentin 300 mg Capsule0.64USDcapsule
Gabapentin 100 mg tablet0.53USDtablet
Gabapentin 100 mg Capsule0.41USDcapsule
Neurontin 250 mg/5ml Solution0.32USDml
Apo-Gabapentin 100 mg Capsule0.26USDcapsule
Co Gabapentin 100 mg Capsule0.26USDcapsule
Mylan-Gabapentin 100 mg Capsule0.26USDcapsule
Novo-Gabapentin 100 mg Capsule0.26USDcapsule
Phl-Gabapentin 100 mg Capsule0.26USDcapsule
Pms-Gabapentin 100 mg Capsule0.26USDcapsule
Ran-Gabapentin 100 mg Capsule0.26USDcapsule
Ratio-Gabapentin 100 mg Capsule0.26USDcapsule
DrugBank does not sell nor buy drugs. Pricing information is supplied for informational purposes only.
Patents
CountryPatent NumberApprovedExpires (estimated)
Canada22159232001-10-092016-04-26
Canada23272852005-06-142019-05-10
United States60544821997-04-252017-04-25
United States72562162002-11-282022-11-28
Properties
Statesolid
Experimental Properties
PropertyValueSource
melting point162-166 °CNot Available
water solubility4490 mg/LNot Available
logP-1.10SANGSTER (1994)
Predicted Properties
PropertyValueSource
Water Solubility4.34ALOGPS
logP-1.9ALOGPS
logP-1.3ChemAxon
logS-1.6ALOGPS
pKa (Strongest Acidic)4.63ChemAxon
pKa (Strongest Basic)9.91ChemAxon
Physiological Charge0ChemAxon
Hydrogen Acceptor Count3ChemAxon
Hydrogen Donor Count2ChemAxon
Polar Surface Area63.32 Å2ChemAxon
Rotatable Bond Count3ChemAxon
Refractivity46.33 m3·mol-1ChemAxon
Polarizability18.92 Å3ChemAxon
Number of Rings1ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterNoChemAxon
Veber's RuleNoChemAxon
MDDR-like RuleNoChemAxon
Spectra
Spectra1D NMR2D NMR
References
Synthesis Reference

Donald E. Butler, Barbara J. Greenman, “Gabapentin mohohydrate and a process for producing the same.” U.S. Patent US4960931, issued May, 1978.

US4960931
General Reference
  1. Mathew NT, Rapoport A, Saper J, Magnus L, Klapper J, Ramadan N, Stacey B, Tepper S: Efficacy of gabapentin in migraine prophylaxis. Headache. 2001 Feb;41(2):119-28. Pubmed
  2. Backonja MM, Serra J: Pharmacologic management part 1: better-studied neuropathic pain diseases. Pain Med. 2004 Mar;5 Suppl 1:S28-47. Pubmed
  3. Choudhuri I, Sarvananthan N, Gottlob I: Survey of management of acquired nystagmus in the United Kingdom. Eye. 2007 Sep;21(9):1194-7. Epub 2006 May 26. Pubmed
  4. Pande AC, Crockatt JG, Janney CA, Werth JL, Tsaroucha G: Gabapentin in bipolar disorder: a placebo-controlled trial of adjunctive therapy. Gabapentin Bipolar Disorder Study Group. Bipolar Disord. 2000 Sep;2(3 Pt 2):249-55. Pubmed
  5. Su TZ, Feng MR, Weber ML: Mediation of highly concentrative uptake of pregabalin by L-type amino acid transport in Chinese hamster ovary and Caco-2 cells. J Pharmacol Exp Ther. 2005 Jun;313(3):1406-15. Epub 2005 Mar 15. Pubmed
External Links
ResourceLink
KEGG DrugD00332
PubChem Compound3446
PubChem Substance46506529
ChemSpider3328
Therapeutic Targets DatabaseDNC000670
PharmGKBPA449720
HETGBN
RxListhttp://www.rxlist.com/cgi/generic/gabapent.htm
Drugs.comhttp://www.drugs.com/gabapentin.html
PDRhealthhttp://www.pdrhealth.com/drug_info/rxdrugprofiles/drugs/neu1289.shtml
WikipediaGabapentin
ATC CodesN03AX12
AHFS Codes
  • 28:12.92
PDB EntriesNot Available
FDA labelshow(1.5 MB)
MSDSshow(73.3 KB)
Interactions
Drug Interactions
Drug
EthotoinIncreases the effect of hydantoin
FosphenytoinGabapentin may increase the effect of fosphenytoin.
MephenytoinIncreases the effect of hydantoin
PhenytoinGabapentin may increase the therapeutic and adverse effects of phenytoin.
TriprolidineThe CNS depressants, Triprolidine and Gabapentin, may increase adverse/toxic effects due to additivity. Monitor for increased CNS depressant effects during concomitant therapy.
Food Interactions
  • Avoid alcohol.
  • Take without regard to meals.

Targets

1. Voltage-dependent calcium channel subunit alpha-2/delta-1

Kind: protein

Organism: Human

Pharmacological action: yes

Actions: inhibitor

Components

Name UniProt ID Details
Voltage-dependent calcium channel subunit alpha-2/delta-1 P54289 Details

References:

  1. Maneuf YP, Luo ZD, Lee K: alpha2delta and the mechanism of action of gabapentin in the treatment of pain. Semin Cell Dev Biol. 2006 Oct;17(5):565-70. Epub 2006 Sep 24. Pubmed
  2. Hota D, Bansal V, Pattanaik S: Evaluation of ketamine, nimodipine, gabapentin and imipramine in partial sciatic nerve transection model of neuropathic pain in rat: an experimental study. Methods Find Exp Clin Pharmacol. 2007 Sep;29(7):443-6. Pubmed
  3. Gazulla J, Tintore MA: The P/Q-type voltage-dependent calcium channel as pharmacological target in spinocerebellar ataxia type 6: gabapentin and pregabalin may be of therapeutic benefit. Med Hypotheses. 2007;68(1):131-6. Epub 2006 Aug 8. Pubmed
  4. Hendrich J, Van Minh AT, Heblich F, Nieto-Rostro M, Watschinger K, Striessnig J, Wratten J, Davies A, Dolphin AC: Pharmacological disruption of calcium channel trafficking by the alpha2delta ligand gabapentin. Proc Natl Acad Sci U S A. 2008 Mar 4;105(9):3628-33. Epub 2008 Feb 25. Pubmed
  5. Hoffmann U, Dilekoz E, Kudo C, Ayata C: Gabapentin suppresses cortical spreading depression susceptibility. J Cereb Blood Flow Metab. 2010 Sep;30(9):1588-92. Epub 2010 Jun 30. Pubmed

2. Voltage-dependent calcium channel subunit alpha-2/delta-2

Kind: protein

Organism: Human

Pharmacological action: yes

Actions: inhibitor

Components

Name UniProt ID Details
Voltage-dependent calcium channel subunit alpha-2/delta-2 Q9NY47 Details

References:

  1. Hota D, Bansal V, Pattanaik S: Evaluation of ketamine, nimodipine, gabapentin and imipramine in partial sciatic nerve transection model of neuropathic pain in rat: an experimental study. Methods Find Exp Clin Pharmacol. 2007 Sep;29(7):443-6. Pubmed
  2. Gazulla J, Tintore MA: The P/Q-type voltage-dependent calcium channel as pharmacological target in spinocerebellar ataxia type 6: gabapentin and pregabalin may be of therapeutic benefit. Med Hypotheses. 2007;68(1):131-6. Epub 2006 Aug 8. Pubmed
  3. Hendrich J, Van Minh AT, Heblich F, Nieto-Rostro M, Watschinger K, Striessnig J, Wratten J, Davies A, Dolphin AC: Pharmacological disruption of calcium channel trafficking by the alpha2delta ligand gabapentin. Proc Natl Acad Sci U S A. 2008 Mar 4;105(9):3628-33. Epub 2008 Feb 25. Pubmed
  4. Hoffmann U, Dilekoz E, Kudo C, Ayata C: Gabapentin suppresses cortical spreading depression susceptibility. J Cereb Blood Flow Metab. 2010 Sep;30(9):1588-92. Epub 2010 Jun 30. Pubmed

3. Voltage-dependent N-type calcium channel subunit alpha-1B

Kind: protein

Organism: Human

Pharmacological action: yes

Actions: inhibitor

Components

Name UniProt ID Details
Voltage-dependent N-type calcium channel subunit alpha-1B Q00975 Details

References:

  1. Cheng JK, Chen CC, Yang JR, Chiou LC: The antiallodynic action target of intrathecal gabapentin: Ca2+ channels, KATP channels or N-methyl-d-aspartic acid receptors? Anesth Analg. 2006 Jan;102(1):182-7. Pubmed
  2. Hendrich J, Van Minh AT, Heblich F, Nieto-Rostro M, Watschinger K, Striessnig J, Wratten J, Davies A, Dolphin AC: Pharmacological disruption of calcium channel trafficking by the alpha2delta ligand gabapentin. Proc Natl Acad Sci U S A. 2008 Mar 4;105(9):3628-33. Epub 2008 Feb 25. Pubmed
  3. Hoffmann U, Dilekoz E, Kudo C, Ayata C: Gabapentin suppresses cortical spreading depression susceptibility. J Cereb Blood Flow Metab. 2010 Sep;30(9):1588-92. Epub 2010 Jun 30. Pubmed

4. Adenosine receptor A1

Kind: protein

Organism: Human

Pharmacological action: unknown

Actions: agonist

Components

Name UniProt ID Details
Adenosine receptor A1 P30542 Details

References:

  1. De Vry J, Kuhl E, Franken-Kunkel P, Eckel G: Pharmacological characterization of the chronic constriction injury model of neuropathic pain. Eur J Pharmacol. 2004 May 3;491(2-3):137-48. Pubmed
  2. Zuchora B, Wielosz M, Urbanska EM: Adenosine A1 receptors and the anticonvulsant potential of drugs effective in the model of 3-nitropropionic acid-induced seizures in mice. Eur Neuropsychopharmacol. 2005 Jan;15(1):85-93. Pubmed
  3. Kralic JE, Criswell HE, Osterman JL, O’Buckley TK, Wilkie ME, Matthews DB, Hamre K, Breese GR, Homanics GE, Morrow AL: Genetic essential tremor in gamma-aminobutyric acidA receptor alpha1 subunit knockout mice. J Clin Invest. 2005 Mar;115(3):774-9. Pubmed

5. NMDA receptor

Kind: protein group

Organism: Human

Pharmacological action: unknown

Components

Name UniProt ID Details
Glutamate receptor ionotropic, NMDA 1 Q05586 Details
Glutamate receptor ionotropic, NMDA 2A Q12879 Details
Glutamate receptor ionotropic, NMDA 2B Q13224 Details
Glutamate receptor ionotropic, NMDA 2C Q14957 Details
Glutamate receptor ionotropic, NMDA 2D O15399 Details
Glutamate receptor ionotropic, NMDA 3A Q8TCU5 Details
Glutamate receptor ionotropic, NMDA 3B O60391 Details

References:

  1. Shimoyama M, Shimoyama N, Hori Y: Gabapentin affects glutamatergic excitatory neurotransmission in the rat dorsal horn. Pain. 2000 Apr;85(3):405-14. Pubmed

Enzymes

1. Branched-chain-amino-acid aminotransferase, cytosolic

Kind: protein

Organism: Human

Pharmacological action: unknown

Actions: inhibitor

Components

Name UniProt ID Details
Branched-chain-amino-acid aminotransferase, cytosolic P54687 Details

References:

  1. Goto M, Miyahara I, Hirotsu K, Conway M, Yennawar N, Islam MM, Hutson SM: Structural determinants for branched-chain aminotransferase isozyme-specific inhibition by the anticonvulsant drug gabapentin. J Biol Chem. 2005 Nov 4;280(44):37246-56. Epub 2005 Sep 1. Pubmed

Comments
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Drug created on June 13, 2005 07:24 / Updated on September 16, 2013 17:12