You are using an unsupported browser. Please upgrade your browser to a newer version to get the best experience on DrugBank.
Identification
NameLevofloxacin
Accession NumberDB01137  (APRD00477, DB06085)
TypeSmall Molecule
GroupsApproved, Investigational
DescriptionA synthetic fluoroquinolone (fluoroquinolones) antibacterial agent that inhibits the supercoiling activity of bacterial DNA gyrase, halting DNA replication. [PubChem]
Structure
Thumb
Synonyms
(-)-Ofloxacin
(3S)-(-)-9-Fluoro-3-methyl-10-(4-methyl-1-piperazinyl)-7-oxo-2,3-dihydro-7H-pyrido[1,2,3-de][1,4]benzoxazine-6-carboxylic acid
(S)-(-)-9-Fluoro-3-methyl-10-(4-methyl-1-piperazinyl)-7-oxo-2,3-dihydro-7H-pyrido[1,2,3-de][1,4]benzooxazine-6-carboxylic acid
(S)-9-Fluoro-2,3-dihydro-3-methyl-10-(4-methyl-1-piperazinyl)-7-oxo-7H-pyrido(1,2,3-de)-1,4-benzoxazine-6-carboxylic acid
(S)-Ofloxacin
L-ofloxacin
Levofloxacine
Levofloxacino
Levofloxacinum
Ofloxacin S-(-)-form
External Identifiers
  • MP-376
Approved Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Act Levofloxacintablet250 mgoralActavis Pharma Company2009-06-24Not applicableCanada
Act Levofloxacintablet500 mgoralActavis Pharma Company2009-06-24Not applicableCanada
Act Levofloxacintablet750 mgoralActavis Pharma Company2009-06-24Not applicableCanada
Auro-levofloxacintablet250 mgoralAuro Pharma Inc2016-04-12Not applicableCanada
Auro-levofloxacintablet500 mgoralAuro Pharma Inc2016-04-12Not applicableCanada
Auro-levofloxacintablet750 mgoralAuro Pharma Inc2016-04-12Not applicableCanada
Ava-levofloxacintablet250 mgoralAvanstra Inc2011-09-152014-08-21Canada
Ava-levofloxacintablet500 mgoralAvanstra Inc2011-09-152014-08-21Canada
Dom-levofloxacintablet500 mgoralDominion PharmacalNot applicableNot applicableCanada
Dom-levofloxacintablet750 mgoralDominion PharmacalNot applicableNot applicableCanada
Dom-levofloxacintablet250 mgoralDominion PharmacalNot applicableNot applicableCanada
Iquixsolution15 mg/mLophthalmicVistakon Pharmaceuticals LLC2004-06-01Not applicableUs
Levaquintablet, film coated500 mg/1oralbryant ranch prepack1996-12-20Not applicableUs
Levaquintablet, film coated500 mg/1oralA S Medication Solutions1996-12-20Not applicableUs
Levaquininjection, solution5 mg/mLintravenousJanssen Pharmaceuticals, Inc.1996-12-20Not applicableUs
Levaquintablet, film coated250 mg/1oralPhysicians Total Care, Inc.2000-05-12Not applicableUs
Levaquinsolution25 mg/mLoralPatriot Pharmaceuticals, Inc.2013-07-01Not applicableUs
Levaquintablet, film coated250 mg/1oralJanssen Pharmaceuticals, Inc.1996-12-20Not applicableUs
Levaquintablet, film coated500 mg/1oralREMEDYREPACK INC.2013-04-10Not applicableUs
Levaquintablet, film coated250 mg/1oralCardinal Health1996-12-20Not applicableUs
Levaquintablet, film coated500 mg/1oralRed Pharm Drug Inc.1996-12-20Not applicableUs
Levaquininjection, solution5 mg/mLintravenousJanssen Pharmaceuticals, Inc.1996-12-20Not applicableUs
Levaquintablet, film coated750 mg/1oralPhysicians Total Care, Inc.2005-08-02Not applicableUs
Levaquintablet, film coated500 mg/1oralRebel Distributors Corp1996-12-20Not applicableUs
Levaquintablet, film coated500 mg/1oralJanssen Pharmaceuticals, Inc.1996-12-20Not applicableUs
Levaquintablet, film coated250 mg/1oralREMEDYREPACK INC.2013-04-11Not applicableUs
Levaquintablet, film coated750 mg/1oralPd Rx Pharmaceuticals, Inc.1996-12-20Not applicableUs
Levaquintablet, film coated750 mg/1oralRed Pharm Drug Inc.1996-12-20Not applicableUs
Levaquininjection, solution5 mg/mLintravenousJanssen Pharmaceuticals, Inc.1996-12-20Not applicableUs
Levaquintablet, film coated500 mg/1oralCardinal Health1996-12-20Not applicableUs
Levaquintablet, film coated750 mg/1oralRebel Distributors Corp1996-12-20Not applicableUs
Levaquintablet, film coated750 mg/1oralJanssen Pharmaceuticals, Inc.1996-12-20Not applicableUs
Levaquintablet250 mgoralJanssen Inc1997-11-282014-10-27Canada
Levaquintablet, film coated500 mg/1oralPd Rx Pharmaceuticals, Inc.1996-12-20Not applicableUs
Levaquintablet, film coated500 mg/1oralLake Erie Medical DBA Quality Care Products LLC2011-01-27Not applicableUs
Levaquintablet, film coated250 mg/1oralRed Pharm Drug Inc.1996-12-20Not applicableUs
Levaquinsolution25 mg/mLoralJanssen Pharmaceuticals, Inc.2004-10-21Not applicableUs
Levaquintablet, film coated750 mg/1oralCardinal Health1996-12-20Not applicableUs
Levaquintablet, film coated500 mg/1oralPd Rx Pharmaceuticals, Inc.1996-12-20Not applicableUs
Levaquintablet, film coated500 mg/1oralPhysicians Total Care, Inc.2000-05-11Not applicableUs
Levaquin 25mg/mlsolution25 mgintravenousJanssen Inc1998-01-292006-08-04Canada
Levaquin 500mgtablet500 mgoralJanssen Inc1997-11-282015-04-02Canada
Levaquin 5mg/mlsolution5 mgintravenousJanssen Inc1997-11-282014-03-19Canada
Levaquin 750mgtablet750 mgoralJanssen Inc2004-01-302015-03-27Canada
Levofloxacintablet500 mgoralCobalt Pharmaceuticals CompanyNot applicableNot applicableCanada
Levofloxacintablet750 mgoralCobalt Pharmaceuticals CompanyNot applicableNot applicableCanada
Levofloxacintablet500 mgoralPro Doc Limitee2013-11-28Not applicableCanada
Levofloxacintablet250 mgoralCobalt Pharmaceuticals CompanyNot applicableNot applicableCanada
Levofloxacin In 5% Dextrose Injectionsolution5 mgintravenousHospira Healthcare Corporation2011-12-23Not applicableCanada
Levofloxacin Injectionsolution5 mgintravenousTeva Canada LimitedNot applicableNot applicableCanada
Mylan-levofloxacintablet250 mgoralMylan Pharmaceuticals Ulc2009-06-24Not applicableCanada
Mylan-levofloxacintablet500 mgoralMylan Pharmaceuticals Ulc2009-06-24Not applicableCanada
Ntp-levofloxacintablet250 mgoralTeva Canada LimitedNot applicableNot applicableCanada
Ntp-levofloxacintablet500 mgoralTeva Canada LimitedNot applicableNot applicableCanada
Ntp-levofloxacintablet750 mgoralTeva Canada LimitedNot applicableNot applicableCanada
PHL-levofloxacintablet250 mgoralPharmel IncNot applicableNot applicableCanada
PHL-levofloxacintablet750 mgoralPharmel IncNot applicableNot applicableCanada
PHL-levofloxacintablet500 mgoralPharmel IncNot applicableNot applicableCanada
PMS-levofloxacintablet250 mgoralPharmascience Inc2009-06-24Not applicableCanada
PMS-levofloxacintablet750 mgoralPharmascience Inc2009-06-24Not applicableCanada
PMS-levofloxacintablet500 mgoralPharmascience Inc2009-06-24Not applicableCanada
Quinsairsolution240 mginhalationRaptor Pharmaceuticals IncNot applicableNot applicableCanada
Quixinsolution5 mg/mLophthalmicVistakon Pharmaceuticals LLC2000-10-01Not applicableUs
Sandoz Levofloxacintablet250 mgoralSandoz Canada Incorporated2009-06-24Not applicableCanada
Sandoz Levofloxacintablet500 mgoralSandoz Canada Incorporated2009-06-24Not applicableCanada
Sandoz Levofloxacintablet750 mgoralSandoz Canada Incorporated2009-06-24Not applicableCanada
Teva-levofloxacintablet750 mgoralTeva Canada Limited2009-06-24Not applicableCanada
Teva-levofloxacintablet250 mgoralTeva Canada Limited2004-11-30Not applicableCanada
Teva-levofloxacintablet500 mgoralTeva Canada Limited2004-11-30Not applicableCanada
Approved Generic Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Apo-levofloxacintablet750 mgoralApotex Inc2009-06-24Not applicableCanada
Apo-levofloxacintablet250 mgoralApotex Inc2009-06-24Not applicableCanada
Apo-levofloxacintablet500 mgoralApotex Inc2009-06-24Not applicableCanada
Levofloxacintablet, film coated500 mg/1oralRebel Distributors Corp2011-06-20Not applicableUs
Levofloxacintablet, film coated750 mg/1oralLake Erie Medical DBA Quality Care Products LLC2011-06-21Not applicableUs
Levofloxacintablet, film coated750 mg/1oralPd Rx Pharmaceuticals, Inc.2011-06-20Not applicableUs
Levofloxacintablet, film coated750 mg/1oralPhysicians Total Care, Inc.2011-06-22Not applicableUs
Levofloxacintablet, film coated250 mg/1oralCitron Pharma LLC2011-06-20Not applicableUs
Levofloxacintablet500 mg/1oralWest ward Pharmaceutical Corp2011-06-21Not applicableUs
Levofloxacintablet, film coated500 mg/1oralDIRECT RX2015-01-01Not applicableUs
Levofloxacintablet500 mg/1oralWockhardt USA LLC.2011-06-20Not applicableUs
Levofloxacintablet, film coated500 mg/1oralBlenheim Pharmacal, Inc.2013-09-05Not applicableUs
Levofloxacintablet, film coated500 mg/1oralZydus Pharmaceuticals (USA) Inc.2012-11-10Not applicableUs
Levofloxacininjection, solution250 mg/50mLintravenousAuro Medics Pharma Llc2016-02-10Not applicableUs
Levofloxacintablet500 mg/1oralTorrent Pharmaceuticals Limited2011-06-20Not applicableUs
Levofloxacintablet, film coated750 mg/1oralCamber Pharmaceuticals, Inc.2015-01-09Not applicableUs
Levofloxacintablet, film coated250 mg/1oralAv Kare, Inc.2013-07-12Not applicableUs
Levofloxacintablet, film coated250 mg/1oralNorthwind Pharmaceuticals2015-05-14Not applicableUs
Levofloxacintablet250 mg/1oralCardinal Health2011-06-23Not applicableUs
Levofloxacintablet, film coated250 mg/1oralTeva Pharmaceuticals USA Inc2011-06-20Not applicableUs
Levofloxacintablet, film coated250 mg/1oralJubilant Cadista Pharmaceuticals Inc.2012-12-02Not applicableUs
Levofloxacintablet, film coated750 mg/1oralbryant ranch prepack2011-06-20Not applicableUs
Levofloxacintablet, film coated750 mg/1oralSandoz Inc2011-06-20Not applicableUs
Levofloxacintablet, film coated250 mg/1oralAmerican Health Packaging2011-07-01Not applicableUs
Levofloxacintablet750 mg/1oralPreferred Pharmaceuticals, Inc.2013-02-04Not applicableUs
Levofloxacintablet, film coated750 mg/1oralREMEDYREPACK INC.2016-04-14Not applicableUs
Levofloxacintablet, film coated750 mg/1oralCadila Healthcare Limited2012-11-10Not applicableUs
Levofloxacintablet, film coated500 mg/1oralBlenheim Pharmacal, Inc.2014-01-14Not applicableUs
Levofloxacintablet, film coated750 mg/1oralPreferred Pharmaceuticals, Inc.2015-01-08Not applicableUs
Levofloxacintablet, film coated500 mg/1oralREMEDYREPACK INC.2016-01-07Not applicableUs
Levofloxacininjection, solution5 mg/mLintravenousSagent Pharmaceuticals2011-06-20Not applicableUs
Levofloxacininjection, solution25 mg/mLintravenousClaris Lifesciences Inc.2013-07-01Not applicableUs
Levofloxacintablet, film coated500 mg/1oralMedsource Pharmaceuticals2011-06-20Not applicableUs
Levofloxacininjection, solution, concentrate500 mg/20mLintravenousAuro Medics Pharma Llc2013-01-24Not applicableUs
Levofloxacintablet500 mg/1oralNew Horizon Rx Group, LLC2013-08-25Not applicableUs
Levofloxacininjection, solution5 mg/mLintravenousSandoz Inc2011-07-07Not applicableUs
Levofloxacintablet, film coated750 mg/1oralProficient Rx LP2011-06-20Not applicableUs
Levofloxacininjection, solution500 mg/100mLintravenousWest ward Pharmaceutical Corp2011-09-16Not applicableUs
Levofloxacintablet750 mg/1oralDIRECT RX2015-01-01Not applicableUs
Levofloxacintablet, film coated500 mg/1oralBoca Pharmacal, LLC2012-08-17Not applicableUs
Levofloxacintablet, film coated250 mg/1oralMajor Pharmaceuticals2013-12-01Not applicableUs
Levofloxacintablet, film coated500 mg/1oralLupin Pharmaceuticals, Inc.2011-06-20Not applicableUs
Levofloxacinsolution5 mg/mLophthalmicAkorn Inc.2011-03-01Not applicableUs
Levofloxacintablet, film coated250 mg/1oralMacleods Pharmaceuticals Limited2012-03-22Not applicableUs
Levofloxacintablet, film coated750 mg/1oralPd Rx Pharmaceuticals, Inc.2011-06-20Not applicableUs
Levofloxacintablet, film coated250 mg/1oralREMEDYREPACK INC.2013-12-31Not applicableUs
Levofloxacintablet250 mg/1oralWockhardt Limited2011-06-20Not applicableUs
Levofloxacintablet, film coated750 mg/1oralRebel Distributors Corp2011-06-20Not applicableUs
Levofloxacintablet, film coated500 mg/1oralLake Erie Medical DBA Quality Care Products LLC2011-06-20Not applicableUs
Levofloxacintablet, film coated500 mg/1oralPd Rx Pharmaceuticals, Inc.2011-06-20Not applicableUs
Levofloxacintablet, film coated250 mg/1oralDr. Reddy's Laboratories Limited2011-06-20Not applicableUs
Levofloxacintablet, film coated500 mg/1oralCitron Pharma LLC2011-06-20Not applicableUs
Levofloxacintablet250 mg/1oralWest ward Pharmaceutical Corp2011-06-21Not applicableUs
Levofloxacintablet, film coated500 mg/1oralProficient Rx2011-06-20Not applicableUs
Levofloxacintablet750 mg/1oralWockhardt USA LLC.2011-06-20Not applicableUs
Levofloxacintablet, film coated750 mg/1oralBlenheim Pharmacal, Inc.2013-11-15Not applicableUs
Levofloxacintablet, film coated750 mg/1oralZydus Pharmaceuticals (USA) Inc.2012-11-10Not applicableUs
Levofloxacininjection, solution500 mg/100mLintravenousAuro Medics Pharma Llc2016-02-10Not applicableUs
Levofloxacintablet750 mg/1oralTorrent Pharmaceuticals Limited2011-06-20Not applicableUs
Levofloxacintablet500 mg/1oralAidarex Pharmaceuticals LLC2011-06-20Not applicableUs
Levofloxacintablet, film coated500 mg/1oralAv Kare, Inc.2013-07-12Not applicableUs
Levofloxacintablet, film coated500 mg/1oralNorthwind Pharmaceuticals2014-03-03Not applicableUs
Levofloxacintablet, film coated500 mg/1oralCardinal Health2013-12-01Not applicableUs
Levofloxacintablet, film coated500 mg/1oralTeva Pharmaceuticals USA Inc2011-06-20Not applicableUs
Levofloxacintablet, film coated500 mg/1oralJubilant Cadista Pharmaceuticals Inc.2012-12-02Not applicableUs
Levofloxacintablet250 mg/1oralbryant ranch prepack2011-06-20Not applicableUs
Levofloxacintablet250 mg/1oralMajor Pharmaceuticals2011-06-23Not applicableUs
Levofloxacintablet, film coated500 mg/1oralAmerican Health Packaging2011-07-01Not applicableUs
Levofloxacintablet, film coated500 mg/1oralH.J. Harkins Company, Inc.2011-11-22Not applicableUs
Levofloxacintablet250 mg/1oralHikma Pharmaceutical2011-06-21Not applicableUs
Levofloxacininjection, solution5 mg/mLintravenousSandoz Inc2011-07-07Not applicableUs
Levofloxacintablet, film coated750 mg/1oralProficient Rx LP2012-11-10Not applicableUs
Levofloxacintablet, film coated250 mg/1oralAurobindo Pharma Limited2011-06-20Not applicableUs
Levofloxacintablet, film coated750 mg/1oralBlenheim Pharmacal, Inc.2015-03-26Not applicableUs
Levofloxacintablet, film coated750 mg/1oralPreferred Pharmaceuticals, Inc.2013-11-14Not applicableUs
Levofloxacininjection, solution5 mg/mLintravenousWG Critical Care, LLC2016-04-14Not applicableUs
Levofloxacininjection, solution5 mg/mLintravenousSagent Pharmaceuticals2011-12-05Not applicableUs
Levofloxacininjection, solution5 mg/mLintravenousClaris Lifesciences Inc.2013-07-01Not applicableUs
Levofloxacinsolution/ drops5 mg/mLophthalmicHi Tech Pharmacal Co., Inc.2011-02-10Not applicableUs
Levofloxacininjection, solution, concentrate750 mg/30mLintravenousAuro Medics Pharma Llc2013-01-24Not applicableUs
Levofloxacintablet, film coated250 mg/1oralPhysicians Total Care, Inc.2011-09-15Not applicableUs
Levofloxacintablet500 mg/1oralWockhardt Limited2011-06-20Not applicableUs
Levofloxacininjection, solution250 mg/50mLintravenousWest ward Pharmaceutical Corp2011-09-16Not applicableUs
Levofloxacintablet, film coated750 mg/1oralDIRECT RX2015-01-01Not applicableUs
Levofloxacintablet, film coated750 mg/1oralBoca Pharmacal, LLC2012-08-17Not applicableUs
Levofloxacintablet, film coated500 mg/1oralMajor Pharmaceuticals2013-12-01Not applicableUs
Levofloxacintablet, film coated750 mg/1oralLupin Pharmaceuticals, Inc.2011-06-20Not applicableUs
Levofloxacintablet, film coated750 mg/1oralCentral Texas Community Health Centers2012-03-22Not applicableUs
Levofloxacininjection25 mg/mLintravenousAkorn, Inc.2011-07-01Not applicableUs
Levofloxacintablet, film coated500 mg/1oralMacleods Pharmaceuticals Limited2012-03-22Not applicableUs
Levofloxacintablet, film coated250 mg/1oralPd Rx Pharmaceuticals, Inc.2011-06-20Not applicableUs
Levofloxacininjection25 mg/mLintravenousHeritage Pharmaceuticals Inc.2013-02-04Not applicableUs
Levofloxacintablet, film coated250 mg/1oralLake Erie Medical DBA Quality Care Products LLC2011-06-20Not applicableUs
Levofloxacintablet, film coated500 mg/1oralPd Rx Pharmaceuticals, Inc.2012-03-22Not applicableUs
Levofloxacintablet, film coated500 mg/1oralDr. Reddy's Laboratories Limited2011-06-20Not applicableUs
Levofloxacintablet, film coated750 mg/1oralCitron Pharma LLC2011-06-20Not applicableUs
Levofloxacininjection, solution5 mg/mLintravenousHospira, Inc.2015-09-03Not applicableUs
Levofloxacintablet, film coated750 mg/1oralProficient Rx2011-06-20Not applicableUs
Levofloxacintablet, film coated250 mg/1oralCadila Healthcare Limited2012-11-10Not applicableUs
Levofloxacintablet, film coated500 mg/1oralBlenheim Pharmacal, Inc.2015-07-15Not applicableUs
Levofloxacintablet, film coated750 mg/1oralPreferred Pharmaceuticals, Inc.2011-06-20Not applicableUs
Levofloxacininjection, solution750 mg/150mLintravenousAuro Medics Pharma Llc2016-02-10Not applicableUs
Levofloxacinsolution/ drops5 mg/mLtopicalPACK Pharmaceuticals, LLC2010-12-20Not applicableUs
Levofloxacintablet750 mg/1oralAidarex Pharmaceuticals LLC2011-06-20Not applicableUs
Levofloxacintablet, film coated750 mg/1oralAv Kare, Inc.2013-07-12Not applicableUs
Levofloxacintablet, film coated250 mg/1oralREMEDYREPACK INC.2013-03-08Not applicableUs
Levofloxacintablet, film coated750 mg/1oralCardinal Health2013-12-01Not applicableUs
Levofloxacintablet, film coated750 mg/1oralTeva Pharmaceuticals USA Inc2011-06-20Not applicableUs
Levofloxacintablet, film coated750 mg/1oralREMEDYREPACK INC.2015-05-20Not applicableUs
Levofloxacintablet, film coated500 mg/1oralReady Meds2011-06-20Not applicableUs
Levofloxacintablet500 mg/1oralMajor Pharmaceuticals2011-06-23Not applicableUs
Levofloxacintablet, film coated750 mg/1oralAmerican Health Packaging2011-07-01Not applicableUs
Levofloxacinsolution25 mg/mLoralHi Tech Pharmacal Co., Inc.2011-06-21Not applicableUs
Levofloxacintablet750 mg/1oralCardinal Health2011-06-23Not applicableUs
Levofloxacintablet500 mg/1oralHikma Pharmaceutical2011-06-21Not applicableUs
Levofloxacintablet, film coated250 mg/1oralSandoz Inc2011-06-20Not applicableUs
Levofloxacininjection5 mg/mLintravenousFresenius Kabi USA, LLC2013-06-20Not applicableUs
Levofloxacintablet, film coated500 mg/1oralAurobindo Pharma Limited2011-06-20Not applicableUs
Levofloxacintablet, film coated500 mg/1oralApotheca Inc.2012-03-22Not applicableUs
Levofloxacintablet750 mg/1oralPreferred Pharmaceuticals, Inc.2013-03-27Not applicableUs
Levofloxacininjection, solution5 mg/mLintravenousWG Critical Care, LLC2016-04-14Not applicableUs
Levofloxacintablet, film coated250 mg/1oralCamber Pharmaceuticals, Inc.2015-01-09Not applicableUs
Levofloxacininjection, solution5 mg/mLintravenousClaris Lifesciences Inc.2013-07-01Not applicableUs
Levofloxacintablet, film coated750 mg/1oralMacleods Pharmaceuticals Limited2012-03-22Not applicableUs
Levofloxacintablet, film coated500 mg/1oralPd Rx Pharmaceuticals, Inc.2011-06-20Not applicableUs
Levofloxacintablet, film coated500 mg/1oralPhysicians Total Care, Inc.2011-06-22Not applicableUs
Levofloxacintablet750 mg/1oralWockhardt Limited2011-06-20Not applicableUs
Levofloxacintablet750 mg/1oralWest ward Pharmaceutical Corp2011-06-21Not applicableUs
Levofloxacintablet, film coated250 mg/1oralDIRECT RX2014-01-01Not applicableUs
Levofloxacintablet250 mg/1oralWockhardt USA LLC.2011-06-20Not applicableUs
Levofloxacintablet, film coated750 mg/1oralMajor Pharmaceuticals2013-12-01Not applicableUs
Levofloxacintablet, film coated250 mg/1oralZydus Pharmaceuticals (USA) Inc.2012-11-10Not applicableUs
Levofloxacintablet, film coated500 mg/1oralProficient Rx LP2012-03-22Not applicableUs
Levofloxacintablet, film coated250 mg/1oralRebel Distributors Corp2011-06-20Not applicableUs
Levofloxacinsolution25 mg/mLoralDepartment Of State Health Services, Pharmacy Branch2011-06-21Not applicableUs
Levofloxacininjection, solution25 mg/mLintravenousSagent Pharmaceuticals2012-01-05Not applicableUs
Levofloxacintablet, film coated500 mg/1oralLake Erie Medical DBA Quality Care Products LLC2011-06-20Not applicableUs
Levofloxacintablet, film coated500 mg/1oralPd Rx Pharmaceuticals, Inc.2012-03-22Not applicableUs
Levofloxacintablet, film coated750 mg/1oralDr. Reddy's Laboratories Limited2011-06-20Not applicableUs
Levofloxacintablet, film coated500 mg/1oralClinical Solutions Wholesale2011-06-20Not applicableUs
Levofloxacininjection, solution5 mg/mLintravenousSandoz Inc2011-07-07Not applicableUs
Levofloxacintablet, film coated500 mg/1oralProficient Rx LP2011-06-20Not applicableUs
Levofloxacintablet, film coated500 mg/1oralCadila Healthcare Limited2012-11-10Not applicableUs
Levofloxacintablet, film coated500 mg/1oralBlenheim Pharmacal, Inc.2013-11-13Not applicableUs
Levofloxacintablet, film coated500 mg/1oralPreferred Pharmaceuticals, Inc.2011-06-20Not applicableUs
Levofloxacintablet, film coated250 mg/1oralLupin Pharmaceuticals, Inc.2011-06-20Not applicableUs
Levofloxacintablet, film coated500 mg/1oralSTAT Rx USA LLC2011-08-13Not applicableUs
Levofloxacintablet250 mg/1oralAidarex Pharmaceuticals LLC2011-06-20Not applicableUs
Levofloxacintablet, film coated500 mg/1oralPd Rx Pharmaceuticals, Inc.2011-06-20Not applicableUs
Levofloxacintablet, film coated500 mg/1oralREMEDYREPACK INC.2013-09-19Not applicableUs
Levofloxacintablet, film coated250 mg/1oralCardinal Health2013-12-01Not applicableUs
Levofloxacininjection, solution750 mg/150mLintravenousWest ward Pharmaceutical Corp2011-09-16Not applicableUs
Levofloxacintablet, film coated500 mg/1oralDIRECT RX2015-01-01Not applicableUs
Levofloxacintablet, film coated250 mg/1oralBoca Pharmacal, LLC2012-08-17Not applicableUs
Levofloxacintablet750 mg/1oralMajor Pharmaceuticals2011-06-23Not applicableUs
Levofloxacintablet, film coated500 mg/1oralCamber Pharmaceuticals, Inc.2015-01-09Not applicableUs
Levofloxacininjection, solution5 mg/mLintravenousClaris Lifesciences Inc.2013-07-01Not applicableUs
Levofloxacintablet, film coated500 mg/1oralUnit Dose Services2011-06-20Not applicableUs
Levofloxacintablet500 mg/1oralCardinal Health2011-06-23Not applicableUs
Levofloxacintablet750 mg/1oralHikma Pharmaceutical2011-06-21Not applicableUs
Levofloxacintablet, film coated500 mg/1oralSandoz Inc2011-06-20Not applicableUs
Levofloxacintablet, film coated500 mg/1oralbryant ranch prepack2011-06-20Not applicableUs
Levofloxacintablet, film coated750 mg/1oralAurobindo Pharma Limited2011-06-20Not applicableUs
Levofloxacintablet250 mg/1oralTorrent Pharmaceuticals Limited2011-06-20Not applicableUs
Levofloxacintablet, film coated500 mg/1oralPreferred Pharmaceuticals, Inc.2011-08-12Not applicableUs
Levofloxacininjection, solution5 mg/mLintravenousWG Critical Care, LLC2016-04-14Not applicableUs
Approved Over the Counter ProductsNot Available
Unapproved/Other Products Not Available
International Brands
NameCompany
CravitNot Available
ElequineNot Available
FloxelNot Available
LeroxacinNot Available
LevokacinNot Available
LevoxNot Available
LevoxacinNot Available
MosardalNot Available
NofaxinNot Available
ReskuinNot Available
TavanicNot Available
Brand mixturesNot Available
Salts
Name/CASStructureProperties
Levofloxacin hemihydrate
138199-71-0
Thumb
  • InChI Key: SUIQUYDRLGGZOL-RCWTXCDDSA-N
  • Monoisotopic Mass: 740.298133282
  • Average Mass: 740.762
DBSALT001001
Categories
UNIIRIX4E89Y14
CAS number100986-85-4
WeightAverage: 361.3675
Monoisotopic: 361.143784348
Chemical FormulaC18H20FN3O4
InChI KeyInChIKey=GSDSWSVVBLHKDQ-JTQLQIEISA-N
InChI
InChI=1S/C18H20FN3O4/c1-10-9-26-17-14-11(16(23)12(18(24)25)8-22(10)14)7-13(19)15(17)21-5-3-20(2)4-6-21/h7-8,10H,3-6,9H2,1-2H3,(H,24,25)/t10-/m0/s1
IUPAC Name
(2S)-7-fluoro-2-methyl-6-(4-methylpiperazin-1-yl)-10-oxo-4-oxa-1-azatricyclo[7.3.1.0⁵,¹³]trideca-5(13),6,8,11-tetraene-11-carboxylic acid
SMILES
C[[email protected]]1COC2=C3N1C=C(C(O)=O)C(=O)C3=CC(F)=C2N1CCN(C)CC1
Taxonomy
DescriptionThis compound belongs to the class of organic compounds known as quinoline carboxylic acids. These are quinolines in which the quinoline ring system is substituted by a carboxyl group at one or more positions.
KingdomOrganic compounds
Super ClassOrganoheterocyclic compounds
ClassQuinolines and derivatives
Sub ClassQuinoline carboxylic acids
Direct ParentQuinoline carboxylic acids
Alternative Parents
Substituents
  • Quinoline-3-carboxylic acid
  • N-arylpiperazine
  • Fluoroquinolone
  • Hydroxyquinoline
  • Dihydroquinolone
  • Aminoquinoline
  • Dihydroquinoline
  • Benzoxazine
  • Pyridine carboxylic acid or derivatives
  • Pyridine carboxylic acid
  • Dialkylarylamine
  • N-alkylpiperazine
  • N-methylpiperazine
  • Fluorobenzene
  • Alkyl aryl ether
  • Benzenoid
  • Pyridine
  • Piperazine
  • 1,4-diazinane
  • Aryl halide
  • Aryl fluoride
  • Heteroaromatic compound
  • Vinylogous amide
  • Tertiary aliphatic amine
  • Tertiary amine
  • Oxacycle
  • Azacycle
  • Monocarboxylic acid or derivatives
  • Ether
  • Carboxylic acid
  • Carboxylic acid derivative
  • Hydrocarbon derivative
  • Organooxygen compound
  • Organonitrogen compound
  • Organofluoride
  • Organohalogen compound
  • Carbonyl group
  • Amine
  • Aromatic heteropolycyclic compound
Molecular FrameworkAromatic heteropolycyclic compounds
External Descriptors
Pharmacology
IndicationFor the treatment of bacterial conjunctivitis caused by susceptible strains of the following organisms: Corynebacterium species, Staphylococus aureus, Staphylococcus epidermidis, Streptococcus pneumoniae, Streptococcus (Groups C/F/G), Viridans group streptococci, Acinetobacter lwoffii, Haemophilus influenzae, Serratia marcescens.
PharmacodynamicsLevofloxacin, a fluoroquinolone antiinfective, is the optically active L-isomer of ofloxacin. Levofloxacin is used to treat bacterial conjunctivitis, sinusitis, chronic bronchitis, community-acquired pneumonia and pneumonia caused by penicillin-resistant strains of Streptococcus pneumoniae, skin and skin structure infections, complicated urinary tract infections and acute pyelonephritis.
Mechanism of actionLevofloxacin inhibits bacterial type II topoisomerases, topoisomerase IV and DNA gyrase. Levofloxacin, like other fluoroquinolones, inhibits the A subunits of DNA gyrase, two subunits encoded by the gyrA gene. This results in strand breakage on a bacterial chromosome, supercoiling, and resealing; DNA replication and transcription is inhibited.
Related Articles
AbsorptionAbsorption of ofloxacin after single or multiple doses of 200 to 400 mg is predictable, and the amount of drug absorbed increases proportionately with the dose.
Volume of distributionNot Available
Protein binding24-38% (to plasma proteins)
Metabolism

Mainly excreted as unchanged drug (87%); undergoes limited metabolism in humans.

Route of eliminationMainly excreted as unchanged drug in the urine.
Half life6-8 hours
ClearanceNot Available
ToxicitySide effects include disorientation, dizziness, drowsiness, hot and cold flashes, nausea, slurring of speech, swelling and numbness in the face
Affected organisms
  • Enteric bacteria and other eubacteria
PathwaysNot Available
SNP Mediated EffectsNot Available
SNP Mediated Adverse Drug ReactionsNot Available
ADMET
Predicted ADMET features
PropertyValueProbability
Human Intestinal AbsorptionNot AvailableNot Available
Blood Brain BarrierNot AvailableNot Available
Caco-2 permeableNot AvailableNot Available
P-glycoprotein substrateNot AvailableNot Available
P-glycoprotein inhibitor INot AvailableNot Available
P-glycoprotein inhibitor IINot AvailableNot Available
Renal organic cation transporterNot AvailableNot Available
CYP450 2C9 substrateNot AvailableNot Available
CYP450 2D6 substrateNot AvailableNot Available
CYP450 3A4 substrateNot AvailableNot Available
CYP450 1A2 substrateNot AvailableNot Available
CYP450 2C9 inhibitorNot AvailableNot Available
CYP450 2D6 inhibitorNot AvailableNot Available
CYP450 2C19 inhibitorNot AvailableNot Available
CYP450 3A4 inhibitorNot AvailableNot Available
CYP450 inhibitory promiscuityNot AvailableNot Available
Ames testNot AvailableNot Available
CarcinogenicityNot AvailableNot Available
BiodegradationNot AvailableNot Available
Rat acute toxicityNot AvailableNot applicable
hERG inhibition (predictor I)Not AvailableNot Available
hERG inhibition (predictor II)Not AvailableNot Available
ADMET data is predicted using admetSAR, a free tool for evaluating chemical ADMET properties. (23092397 )
Pharmacoeconomics
ManufacturersNot Available
Packagers
Dosage forms
FormRouteStrength
Solutionophthalmic15 mg/mL
Solutionoral25 mg/mL
Solutionintravenous25 mg
Injectionintravenous25 mg/mL
Injectionintravenous5 mg/mL
Injection, solutionintravenous25 mg/mL
Injection, solutionintravenous250 mg/50mL
Injection, solutionintravenous5 mg/mL
Injection, solutionintravenous500 mg/100mL
Injection, solutionintravenous750 mg/150mL
Injection, solution, concentrateintravenous500 mg/20mL
Injection, solution, concentrateintravenous750 mg/30mL
Solutionophthalmic5 mg/mL
Solution/ dropsophthalmic5 mg/mL
Solution/ dropstopical5 mg/mL
Tabletoral250 mg/1
Tabletoral500 mg/1
Tabletoral750 mg/1
Tablet, film coatedoral250 mg/1
Tablet, film coatedoral500 mg/1
Tablet, film coatedoral750 mg/1
Solutionintravenous5 mg
Tabletoral250 mg
Tabletoral500 mg
Solutioninhalation240 mg
Tabletoral750 mg
Prices
Unit descriptionCostUnit
Iquix 1.5% Solution 5ml Bottle81.68USD bottle
Levofloxacin hemihydr 100% powder42.69USD g
Levaquin 750 mg tablet28.06USD each
Levaquin 750 mg leva-pak tablet27.51USD tablet
Levaquin 500 mg tablet16.57USD tablet
Iquix 1.5% eye drops15.71USD ml
Levaquin 250 mg tablet13.71USD tablet
Quixin 0.5% eye drops12.21USD ml
Quixin 0.5% Solution11.4USD ml
Levaquin i.v. 25 mg/ml vial1.94USD ml
Levaquin 500 mg/100 ml d5w0.44USD ml
DrugBank does not sell nor buy drugs. Pricing information is supplied for informational purposes only.
Patents
Patent NumberPediatric ExtensionApprovedExpires (estimated)
US5053407 No1993-12-202010-12-20Us
US6806256 Yes2002-08-262022-08-26Us
Properties
StateSolid
Experimental Properties
PropertyValueSource
water solubilityInsolubleNot Available
logP2.1Not Available
Predicted Properties
PropertyValueSource
Water Solubility1.44 mg/mLALOGPS
logP-0.02ALOGPS
logP0.65ChemAxon
logS-2.4ALOGPS
pKa (Strongest Acidic)5.45ChemAxon
pKa (Strongest Basic)6.2ChemAxon
Physiological Charge-1ChemAxon
Hydrogen Acceptor Count7ChemAxon
Hydrogen Donor Count1ChemAxon
Polar Surface Area73.32 Å2ChemAxon
Rotatable Bond Count2ChemAxon
Refractivity94.94 m3·mol-1ChemAxon
Polarizability36.69 Å3ChemAxon
Number of Rings4ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleYesChemAxon
Spectra
Mass Spec (NIST)Not Available
Spectra
Spectrum TypeDescriptionSplash Key
LC-MS/MSLC-MS/MS Spectrum - Quattro_QQQ 10V, N/A (Annotated)splash10-00gm-1315975420-b0c4e6cdef799fda69b4View in MoNA
LC-MS/MSLC-MS/MS Spectrum - Quattro_QQQ 25V, N/A (Annotated)splash10-0abc-3459425420-e8a4ecd2f8aea93fa660View in MoNA
LC-MS/MSLC-MS/MS Spectrum - Quattro_QQQ 40V, N/A (Annotated)splash10-0h9p-3513893500-1d5c8069419fa2c37ebbView in MoNA
1D NMR1H NMR SpectrumNot Available
2D NMR[1H,13C] 2D NMR SpectrumNot Available
References
Synthesis Reference

Valerie Niddam-Hildesheim, “Preparation of levofloxacin and forms thereof.” U.S. Patent US20030130507, issued July 10, 2003.

US20030130507
General ReferencesNot Available
External Links
ATC CodesJ01RA05A02BD10S01AE05J01MA12
AHFS Codes
  • 08:12.18
PDB EntriesNot Available
FDA labelDownload (139 KB)
MSDSNot Available
Interactions
Drug Interactions
Drug
AcebutololThe serum concentration of Acebutolol can be increased when it is combined with Levofloxacin.
AcetaminophenThe serum concentration of Levofloxacin can be increased when it is combined with Acetaminophen.
AcetyldigitoxinAcetyldigitoxin may decrease the cardiotoxic activities of Levofloxacin.
Acetylsalicylic acidThe serum concentration of Acetylsalicylic acid can be increased when it is combined with Levofloxacin.
AfatinibThe serum concentration of Afatinib can be increased when it is combined with Levofloxacin.
AlbendazoleThe serum concentration of Levofloxacin can be increased when it is combined with Albendazole.
AldosteroneThe serum concentration of Levofloxacin can be decreased when it is combined with Aldosterone.
AldosteroneThe serum concentration of Aldosterone can be increased when it is combined with Levofloxacin.
AlectinibThe serum concentration of Levofloxacin can be increased when it is combined with Alectinib.
AlfentanilThe serum concentration of Levofloxacin can be increased when it is combined with Alfentanil.
AlfuzosinAlfuzosin may increase the QTc-prolonging activities of Levofloxacin.
AlitretinoinThe serum concentration of Alitretinoin can be increased when it is combined with Levofloxacin.
AmantadineAmantadine may increase the QTc-prolonging activities of Levofloxacin.
AmbrisentanThe serum concentration of Ambrisentan can be increased when it is combined with Levofloxacin.
Aminohippuric acidThe serum concentration of Levofloxacin can be increased when it is combined with Aminohippuric acid.
AmiodaroneLevofloxacin may increase the QTc-prolonging activities of Amiodarone.
AmiodaroneThe serum concentration of Levofloxacin can be decreased when it is combined with Amiodarone.
AmitriptylineAmitriptyline may increase the QTc-prolonging activities of Levofloxacin.
AmitriptylineThe serum concentration of Amitriptyline can be increased when it is combined with Levofloxacin.
AmlodipineThe serum concentration of Levofloxacin can be increased when it is combined with Amlodipine.
AmoxapineAmoxapine may increase the QTc-prolonging activities of Levofloxacin.
AmprenavirThe serum concentration of Levofloxacin can be decreased when it is combined with Amprenavir.
AmsacrineThe serum concentration of Levofloxacin can be increased when it is combined with Amsacrine.
AnagrelideLevofloxacin may increase the QTc-prolonging activities of Anagrelide.
ApixabanThe serum concentration of Apixaban can be increased when it is combined with Levofloxacin.
ApomorphineApomorphine may increase the QTc-prolonging activities of Levofloxacin.
ArformoterolArformoterol may increase the QTc-prolonging activities of Levofloxacin.
AripiprazoleAripiprazole may increase the QTc-prolonging activities of Levofloxacin.
Arsenic trioxideLevofloxacin may increase the QTc-prolonging activities of Arsenic trioxide.
ArtemetherLevofloxacin may increase the QTc-prolonging activities of Artemether.
AsenapineLevofloxacin may increase the QTc-prolonging activities of Asenapine.
AstemizoleThe serum concentration of Levofloxacin can be increased when it is combined with Astemizole.
AtazanavirAtazanavir may increase the QTc-prolonging activities of Levofloxacin.
AtazanavirThe serum concentration of Atazanavir can be increased when it is combined with Levofloxacin.
AtenololThe serum concentration of Levofloxacin can be increased when it is combined with Atenolol.
AtomoxetineAtomoxetine may increase the QTc-prolonging activities of Levofloxacin.
AtorvastatinThe serum concentration of Levofloxacin can be increased when it is combined with Atorvastatin.
AxitinibThe serum concentration of Axitinib can be increased when it is combined with Levofloxacin.
AzelastineThe serum concentration of Levofloxacin can be increased when it is combined with Azelastine.
AzithromycinLevofloxacin may increase the QTc-prolonging activities of Azithromycin.
AzithromycinThe serum concentration of Levofloxacin can be increased when it is combined with Azithromycin.
BedaquilineLevofloxacin may increase the QTc-prolonging activities of Bedaquiline.
BenzocaineThe serum concentration of Levofloxacin can be increased when it is combined with Benzocaine.
BepridilThe serum concentration of Levofloxacin can be increased when it is combined with Bepridil.
BetamethasoneThe serum concentration of Betamethasone can be increased when it is combined with Levofloxacin.
BevacizumabBevacizumab may increase the cardiotoxic activities of Levofloxacin.
BiperidenThe serum concentration of Levofloxacin can be increased when it is combined with Biperiden.
BoceprevirThe serum concentration of Boceprevir can be increased when it is combined with Levofloxacin.
BortezomibBortezomib may increase the QTc-prolonging activities of Levofloxacin.
BosutinibThe serum concentration of Bosutinib can be increased when it is combined with Levofloxacin.
Brentuximab vedotinThe serum concentration of Brentuximab vedotin can be increased when it is combined with Levofloxacin.
BromocriptineThe serum concentration of Levofloxacin can be increased when it is combined with Bromocriptine.
BuprenorphineThe serum concentration of Levofloxacin can be increased when it is combined with Buprenorphine.
BuserelinBuserelin may increase the QTc-prolonging activities of Levofloxacin.
BuspironeThe serum concentration of Levofloxacin can be increased when it is combined with Buspirone.
CabazitaxelThe serum concentration of Cabazitaxel can be increased when it is combined with Levofloxacin.
CaffeineThe serum concentration of Caffeine can be increased when it is combined with Levofloxacin.
CamptothecinThe serum concentration of Camptothecin can be increased when it is combined with Levofloxacin.
CanagliflozinThe serum concentration of Canagliflozin can be increased when it is combined with Levofloxacin.
CandesartanThe serum concentration of Levofloxacin can be increased when it is combined with Candesartan.
CaptoprilThe serum concentration of Levofloxacin can be increased when it is combined with Captopril.
CarbamazepineThe serum concentration of Levofloxacin can be decreased when it is combined with Carbamazepine.
CarbamazepineThe serum concentration of Carbamazepine can be increased when it is combined with Levofloxacin.
CarfilzomibThe serum concentration of Carfilzomib can be increased when it is combined with Levofloxacin.
CarvedilolThe serum concentration of Levofloxacin can be increased when it is combined with Carvedilol.
CaspofunginThe serum concentration of Levofloxacin can be increased when it is combined with Caspofungin.
CeritinibCeritinib may increase the QTc-prolonging activities of Levofloxacin.
CeritinibThe serum concentration of Ceritinib can be increased when it is combined with Levofloxacin.
CerivastatinThe serum concentration of Cerivastatin can be increased when it is combined with Levofloxacin.
ChloroquineLevofloxacin may increase the QTc-prolonging activities of Chloroquine.
ChloroquineThe serum concentration of Levofloxacin can be increased when it is combined with Chloroquine.
ChlorpromazineThe serum concentration of Levofloxacin can be increased when it is combined with Chlorpromazine.
ChlorpropamideThe serum concentration of Levofloxacin can be increased when it is combined with Chlorpropamide.
ChlorprothixeneThe serum concentration of Levofloxacin can be increased when it is combined with Chlorprothixene.
CholesterolThe serum concentration of Levofloxacin can be increased when it is combined with Cholesterol.
Cholic AcidThe serum concentration of Levofloxacin can be decreased when it is combined with Cholic Acid.
CilazaprilThe serum concentration of Levofloxacin can be increased when it is combined with Cilazapril.
CimetidineThe serum concentration of Levofloxacin can be decreased when it is combined with Cimetidine.
CimetidineThe serum concentration of Cimetidine can be increased when it is combined with Levofloxacin.
CiprofloxacinThe serum concentration of Levofloxacin can be increased when it is combined with Ciprofloxacin.
CisaprideLevofloxacin may increase the QTc-prolonging activities of Cisapride.
CisplatinThe serum concentration of Cisplatin can be increased when it is combined with Levofloxacin.
CitalopramLevofloxacin may increase the QTc-prolonging activities of Citalopram.
CitalopramThe serum concentration of Levofloxacin can be increased when it is combined with Citalopram.
ClarithromycinThe serum concentration of Levofloxacin can be increased when it is combined with Clarithromycin.
ClobazamThe serum concentration of Clobazam can be increased when it is combined with Levofloxacin.
ClofazimineThe serum concentration of Levofloxacin can be increased when it is combined with Clofazimine.
ClomifeneThe serum concentration of Clomifene can be increased when it is combined with Levofloxacin.
ClomipramineClomipramine may increase the QTc-prolonging activities of Levofloxacin.
ClonidineThe serum concentration of Clonidine can be increased when it is combined with Levofloxacin.
ClopidogrelThe serum concentration of Clopidogrel can be increased when it is combined with Levofloxacin.
ClotrimazoleThe serum concentration of Levofloxacin can be decreased when it is combined with Clotrimazole.
ClozapineClozapine may increase the QTc-prolonging activities of Levofloxacin.
ClozapineThe serum concentration of Clozapine can be increased when it is combined with Levofloxacin.
CobicistatThe serum concentration of Levofloxacin can be increased when it is combined with Cobicistat.
CobimetinibThe serum concentration of Cobimetinib can be increased when it is combined with Levofloxacin.
ColchicineThe serum concentration of Levofloxacin can be increased when it is combined with Colchicine.
ColforsinThe serum concentration of Levofloxacin can be increased when it is combined with Colforsin.
Conjugated Equine EstrogensThe serum concentration of Conjugated Equine Estrogens can be increased when it is combined with Levofloxacin.
CrizotinibThe serum concentration of Crizotinib can be increased when it is combined with Levofloxacin.
CyclophosphamideCyclophosphamide may increase the cardiotoxic activities of Levofloxacin.
CyclosporineThe serum concentration of Levofloxacin can be decreased when it is combined with Cyclosporine.
CyclosporineThe serum concentration of Cyclosporine can be increased when it is combined with Levofloxacin.
Dabigatran etexilateThe serum concentration of Dabigatran etexilate can be increased when it is combined with Levofloxacin.
DabrafenibDabrafenib may increase the QTc-prolonging activities of Levofloxacin.
DabrafenibThe serum concentration of Dabrafenib can be increased when it is combined with Levofloxacin.
DaclatasvirThe serum concentration of Levofloxacin can be increased when it is combined with Daclatasvir.
DactinomycinThe serum concentration of Levofloxacin can be increased when it is combined with Dactinomycin.
DapagliflozinThe serum concentration of Dapagliflozin can be increased when it is combined with Levofloxacin.
DasatinibDasatinib may increase the QTc-prolonging activities of Levofloxacin.
DasatinibThe serum concentration of Dasatinib can be increased when it is combined with Levofloxacin.
DaunorubicinThe serum concentration of Levofloxacin can be decreased when it is combined with Daunorubicin.
DaunorubicinThe serum concentration of Daunorubicin can be increased when it is combined with Levofloxacin.
DebrisoquinThe serum concentration of Debrisoquin can be increased when it is combined with Levofloxacin.
DegarelixDegarelix may increase the QTc-prolonging activities of Levofloxacin.
DesfluraneDesflurane may increase the QTc-prolonging activities of Levofloxacin.
DesipramineDesipramine may increase the QTc-prolonging activities of Levofloxacin.
DeslanosideDeslanoside may decrease the cardiotoxic activities of Levofloxacin.
DesloratadineThe serum concentration of Levofloxacin can be increased when it is combined with Desloratadine.
DexamethasoneThe serum concentration of Levofloxacin can be decreased when it is combined with Dexamethasone.
DexamethasoneThe serum concentration of Dexamethasone can be increased when it is combined with Levofloxacin.
DextromethorphanThe serum concentration of Levofloxacin can be increased when it is combined with Dextromethorphan.
DiazepamThe serum concentration of Diazepam can be increased when it is combined with Levofloxacin.
DiclofenacThe serum concentration of Levofloxacin can be increased when it is combined with Diclofenac.
DiethylstilbestrolThe serum concentration of Diethylstilbestrol can be increased when it is combined with Levofloxacin.
DigitoxinDigitoxin may decrease the cardiotoxic activities of Levofloxacin.
DigitoxinThe serum concentration of Digitoxin can be increased when it is combined with Levofloxacin.
DigoxinDigoxin may decrease the cardiotoxic activities of Levofloxacin.
DigoxinThe serum concentration of Digoxin can be increased when it is combined with Levofloxacin.
DihydroergotamineThe serum concentration of Levofloxacin can be increased when it is combined with Dihydroergotamine.
DihydrotestosteroneThe serum concentration of Dihydrotestosterone can be increased when it is combined with Levofloxacin.
DiltiazemThe serum concentration of Levofloxacin can be increased when it is combined with Diltiazem.
DiphenhydramineDiphenhydramine may increase the QTc-prolonging activities of Levofloxacin.
DipyridamoleThe serum concentration of Levofloxacin can be increased when it is combined with Dipyridamole.
DisopyramideLevofloxacin may increase the QTc-prolonging activities of Disopyramide.
DocetaxelThe serum concentration of Docetaxel can be increased when it is combined with Levofloxacin.
DocetaxelThe risk or severity of adverse effects can be increased when Docetaxel is combined with Levofloxacin.
DofetilideLevofloxacin may increase the QTc-prolonging activities of Dofetilide.
DolasetronDolasetron may increase the QTc-prolonging activities of Levofloxacin.
DomperidoneLevofloxacin may increase the QTc-prolonging activities of Domperidone.
DoxazosinThe serum concentration of Levofloxacin can be increased when it is combined with Doxazosin.
DoxepinDoxepin may increase the QTc-prolonging activities of Levofloxacin.
DoxorubicinThe serum concentration of Levofloxacin can be decreased when it is combined with Doxorubicin.
DoxorubicinThe serum concentration of Doxorubicin can be increased when it is combined with Levofloxacin.
DronabinolThe serum concentration of Levofloxacin can be increased when it is combined with Dronabinol.
DronedaroneLevofloxacin may increase the QTc-prolonging activities of Dronedarone.
DronedaroneThe serum concentration of Levofloxacin can be increased when it is combined with Dronedarone.
DroperidolDroperidol may increase the QTc-prolonging activities of Levofloxacin.
EdoxabanThe serum concentration of Edoxaban can be increased when it is combined with Levofloxacin.
ElbasvirThe serum concentration of Levofloxacin can be increased when it is combined with Elbasvir.
EletriptanThe serum concentration of Eletriptan can be increased when it is combined with Levofloxacin.
EliglustatLevofloxacin may increase the QTc-prolonging activities of Eliglustat.
EnalaprilThe serum concentration of Levofloxacin can be increased when it is combined with Enalapril.
EnzalutamideThe serum concentration of Levofloxacin can be increased when it is combined with Enzalutamide.
EpinastineThe serum concentration of Epinastine can be increased when it is combined with Levofloxacin.
ErgonovineThe serum concentration of Levofloxacin can be increased when it is combined with Ergonovine.
ErgotamineThe serum concentration of Levofloxacin can be increased when it is combined with Ergotamine.
EribulinEribulin may increase the QTc-prolonging activities of Levofloxacin.
ErlotinibThe serum concentration of Erlotinib can be increased when it is combined with Levofloxacin.
ErythromycinThe serum concentration of Levofloxacin can be decreased when it is combined with Erythromycin.
ErythromycinThe serum concentration of Erythromycin can be increased when it is combined with Levofloxacin.
EscitalopramLevofloxacin may increase the QTc-prolonging activities of Escitalopram.
EstradiolThe serum concentration of Estradiol can be increased when it is combined with Levofloxacin.
EstramustineThe serum concentration of Levofloxacin can be increased when it is combined with Estramustine.
EstriolThe serum concentration of Levofloxacin can be decreased when it is combined with Estriol.
EstriolThe serum concentration of Estriol can be increased when it is combined with Levofloxacin.
EstroneThe serum concentration of Levofloxacin can be decreased when it is combined with Estrone.
EstroneThe serum concentration of Estrone can be increased when it is combined with Levofloxacin.
Ethinyl EstradiolThe serum concentration of Ethinyl Estradiol can be increased when it is combined with Levofloxacin.
EtoposideThe serum concentration of Levofloxacin can be increased when it is combined with Etoposide.
EtravirineThe serum concentration of Levofloxacin can be increased when it is combined with Etravirine.
EverolimusThe serum concentration of Everolimus can be increased when it is combined with Levofloxacin.
EzetimibeThe serum concentration of Ezetimibe can be increased when it is combined with Levofloxacin.
EzogabineEzogabine may increase the QTc-prolonging activities of Levofloxacin.
FamotidineFamotidine may increase the QTc-prolonging activities of Levofloxacin.
FelbamateFelbamate may increase the QTc-prolonging activities of Levofloxacin.
FelodipineThe serum concentration of Levofloxacin can be increased when it is combined with Felodipine.
FentanylThe serum concentration of Levofloxacin can be increased when it is combined with Fentanyl.
FesoterodineThe serum concentration of Fesoterodine can be increased when it is combined with Levofloxacin.
FexofenadineThe serum concentration of Fexofenadine can be increased when it is combined with Levofloxacin.
FidaxomicinThe serum concentration of Fidaxomicin can be increased when it is combined with Levofloxacin.
FingolimodFingolimod may increase the QTc-prolonging activities of Levofloxacin.
FlecainideLevofloxacin may increase the QTc-prolonging activities of Flecainide.
FluconazoleFluconazole may increase the QTc-prolonging activities of Levofloxacin.
FluoxetineLevofloxacin may increase the QTc-prolonging activities of Fluoxetine.
FluoxetineThe serum concentration of Levofloxacin can be increased when it is combined with Fluoxetine.
FlupentixolLevofloxacin may increase the QTc-prolonging activities of Flupentixol.
FlupentixolThe serum concentration of Levofloxacin can be increased when it is combined with Flupentixol.
FluphenazineThe serum concentration of Levofloxacin can be increased when it is combined with Fluphenazine.
FlurazepamThe serum concentration of Levofloxacin can be increased when it is combined with Flurazepam.
Fluticasone furoateThe serum concentration of Fluticasone furoate can be increased when it is combined with Levofloxacin.
FluvoxamineThe serum concentration of Levofloxacin can be increased when it is combined with Fluvoxamine.
FormoterolFormoterol may increase the QTc-prolonging activities of Levofloxacin.
FoscarnetFoscarnet may increase the QTc-prolonging activities of Levofloxacin.
Gadobenic acidGadobenic acid may increase the QTc-prolonging activities of Levofloxacin.
GalantamineGalantamine may increase the QTc-prolonging activities of Levofloxacin.
GefitinibThe serum concentration of Gefitinib can be increased when it is combined with Levofloxacin.
GemcitabineThe serum concentration of Gemcitabine can be increased when it is combined with Levofloxacin.
GemifloxacinLevofloxacin may increase the QTc-prolonging activities of Gemifloxacin.
GenisteinThe serum concentration of Levofloxacin can be increased when it is combined with Genistein.
GlyburideThe serum concentration of Levofloxacin can be increased when it is combined with Glyburide.
GlycerolThe serum concentration of Levofloxacin can be increased when it is combined with Glycerol.
GoserelinGoserelin may increase the QTc-prolonging activities of Levofloxacin.
Gramicidin DThe serum concentration of Levofloxacin can be increased when it is combined with Gramicidin D.
GranisetronGranisetron may increase the QTc-prolonging activities of Levofloxacin.
GrazoprevirThe serum concentration of Grazoprevir can be increased when it is combined with Levofloxacin.
GrepafloxacinThe serum concentration of Grepafloxacin can be increased when it is combined with Levofloxacin.
HaloperidolThe serum concentration of Levofloxacin can be increased when it is combined with Haloperidol.
HistrelinHistrelin may increase the QTc-prolonging activities of Levofloxacin.
HydrocortisoneThe serum concentration of Levofloxacin can be increased when it is combined with Hydrocortisone.
HydroxyzineHydroxyzine may increase the QTc-prolonging activities of Levofloxacin.
IbandronateIbandronate may increase the QTc-prolonging activities of Levofloxacin.
IbuprofenThe serum concentration of Ibuprofen can be increased when it is combined with Levofloxacin.
IbutilideLevofloxacin may increase the QTc-prolonging activities of Ibutilide.
IdelalisibThe serum concentration of Idelalisib can be increased when it is combined with Levofloxacin.
IloperidoneLevofloxacin may increase the QTc-prolonging activities of Iloperidone.
ImatinibThe serum concentration of Imatinib can be increased when it is combined with Levofloxacin.
ImipramineImipramine may increase the QTc-prolonging activities of Levofloxacin.
ImipramineThe serum concentration of Imipramine can be increased when it is combined with Levofloxacin.
IndacaterolIndacaterol may increase the QTc-prolonging activities of Levofloxacin.
IndacaterolThe serum concentration of Indacaterol can be increased when it is combined with Levofloxacin.
IndapamideIndapamide may increase the QTc-prolonging activities of Levofloxacin.
IndinavirThe serum concentration of Levofloxacin can be decreased when it is combined with Indinavir.
IndinavirThe serum concentration of Indinavir can be increased when it is combined with Levofloxacin.
IndomethacinThe serum concentration of Levofloxacin can be increased when it is combined with Indomethacin.
IrinotecanThe serum concentration of Irinotecan can be increased when it is combined with Levofloxacin.
IsavuconazoniumThe serum concentration of Levofloxacin can be increased when it is combined with Isavuconazonium.
IsofluraneIsoflurane may increase the QTc-prolonging activities of Levofloxacin.
IsradipineIsradipine may increase the QTc-prolonging activities of Levofloxacin.
ItraconazoleItraconazole may increase the QTc-prolonging activities of Levofloxacin.
IvabradineIvabradine may increase the QTc-prolonging activities of Levofloxacin.
IvacaftorThe serum concentration of Levofloxacin can be increased when it is combined with Ivacaftor.
IvermectinThe serum concentration of Levofloxacin can be increased when it is combined with Ivermectin.
KetamineThe serum concentration of Levofloxacin can be increased when it is combined with Ketamine.
KetazolamThe serum concentration of Ketazolam can be increased when it is combined with Levofloxacin.
KetoconazoleKetoconazole may increase the QTc-prolonging activities of Levofloxacin.
KetoconazoleThe serum concentration of Ketoconazole can be increased when it is combined with Levofloxacin.
LamivudineThe serum concentration of Lamivudine can be increased when it is combined with Levofloxacin.
LamotrigineThe serum concentration of Lamotrigine can be increased when it is combined with Levofloxacin.
LansoprazoleThe serum concentration of Levofloxacin can be increased when it is combined with Lansoprazole.
LapatinibLapatinib may increase the QTc-prolonging activities of Levofloxacin.
LedipasvirThe serum concentration of Ledipasvir can be increased when it is combined with Levofloxacin.
LenalidomideThe serum concentration of Lenalidomide can be increased when it is combined with Levofloxacin.
LenvatinibLenvatinib may increase the QTc-prolonging activities of Levofloxacin.
LenvatinibThe serum concentration of Lenvatinib can be increased when it is combined with Levofloxacin.
LeuprolideLeuprolide may increase the QTc-prolonging activities of Levofloxacin.
LevetiracetamThe serum concentration of Levetiracetam can be increased when it is combined with Levofloxacin.
LevomilnacipranThe serum concentration of Levomilnacipran can be increased when it is combined with Levofloxacin.
LevothyroxineThe serum concentration of Levofloxacin can be decreased when it is combined with Levothyroxine.
LidocaineThe serum concentration of Levofloxacin can be increased when it is combined with Lidocaine.
LinagliptinThe serum concentration of Linagliptin can be increased when it is combined with Levofloxacin.
LiothyronineThe serum concentration of Levofloxacin can be decreased when it is combined with Liothyronine.
LiotrixThe serum concentration of Levofloxacin can be decreased when it is combined with Liotrix.
LisinoprilThe serum concentration of Levofloxacin can be increased when it is combined with Lisinopril.
LithiumLithium may increase the QTc-prolonging activities of Levofloxacin.
LomitapideThe serum concentration of Levofloxacin can be increased when it is combined with Lomitapide.
LoperamideThe serum concentration of Levofloxacin can be increased when it is combined with Loperamide.
LopinavirLevofloxacin may increase the QTc-prolonging activities of Lopinavir.
LopinavirThe serum concentration of Levofloxacin can be increased when it is combined with Lopinavir.
LoratadineThe serum concentration of Levofloxacin can be increased when it is combined with Loratadine.
LosartanThe serum concentration of Levofloxacin can be increased when it is combined with Losartan.
LovastatinThe serum concentration of Levofloxacin can be increased when it is combined with Lovastatin.
LumacaftorThe serum concentration of Levofloxacin can be decreased when it is combined with Lumacaftor.
LumefantrineLevofloxacin may increase the QTc-prolonging activities of Lumefantrine.
MannitolThe serum concentration of Mannitol can be increased when it is combined with Levofloxacin.
MaprotilineMaprotiline may increase the QTc-prolonging activities of Levofloxacin.
MebendazoleThe serum concentration of Levofloxacin can be increased when it is combined with Mebendazole.
MefloquineMefloquine may increase the QTc-prolonging activities of Levofloxacin.
Megestrol acetateThe serum concentration of Levofloxacin can be increased when it is combined with Megestrol acetate.
MeprobamateThe serum concentration of Levofloxacin can be increased when it is combined with Meprobamate.
MethadoneLevofloxacin may increase the QTc-prolonging activities of Methadone.
MethadoneThe serum concentration of Levofloxacin can be increased when it is combined with Methadone.
MethotrexateThe serum concentration of Methotrexate can be increased when it is combined with Levofloxacin.
MethotrimeprazineMethotrimeprazine may increase the QTc-prolonging activities of Levofloxacin.
MethylprednisoloneThe serum concentration of Methylprednisolone can be increased when it is combined with Levofloxacin.
MetoclopramideMetoclopramide may increase the QTc-prolonging activities of Levofloxacin.
MetoprololThe serum concentration of Levofloxacin can be increased when it is combined with Metoprolol.
MetronidazoleMetronidazole may increase the QTc-prolonging activities of Levofloxacin.
MibefradilThe serum concentration of Levofloxacin can be increased when it is combined with Mibefradil.
MiconazoleThe serum concentration of Levofloxacin can be increased when it is combined with Miconazole.
MidazolamThe serum concentration of Levofloxacin can be decreased when it is combined with Midazolam.
MidazolamThe serum concentration of Midazolam can be increased when it is combined with Levofloxacin.
MifepristoneMifepristone may increase the QTc-prolonging activities of Levofloxacin.
MirabegronMirabegron may increase the QTc-prolonging activities of Levofloxacin.
MirabegronThe serum concentration of Mirabegron can be increased when it is combined with Levofloxacin.
MirtazapineMirtazapine may increase the QTc-prolonging activities of Levofloxacin.
MitomycinThe serum concentration of Levofloxacin can be increased when it is combined with Mitomycin.
MitoxantroneThe serum concentration of Levofloxacin can be decreased when it is combined with Mitoxantrone.
MitoxantroneThe serum concentration of Mitoxantrone can be increased when it is combined with Levofloxacin.
MoexiprilMoexipril may increase the QTc-prolonging activities of Levofloxacin.
MorphineThe serum concentration of Levofloxacin can be increased when it is combined with Morphine.
MoxifloxacinMoxifloxacin may increase the QTc-prolonging activities of Levofloxacin.
Mycophenolate mofetilThe serum concentration of Mycophenolate mofetil can be increased when it is combined with Levofloxacin.
NadololThe serum concentration of Nadolol can be increased when it is combined with Levofloxacin.
NaloxegolThe serum concentration of Naloxegol can be increased when it is combined with Levofloxacin.
NaloxoneThe serum concentration of Naloxone can be increased when it is combined with Levofloxacin.
NaltrexoneThe serum concentration of Levofloxacin can be increased when it is combined with Naltrexone.
NaringeninThe serum concentration of Levofloxacin can be increased when it is combined with Naringenin.
NefazodoneThe serum concentration of Levofloxacin can be decreased when it is combined with Nefazodone.
NelfinavirNelfinavir may increase the QTc-prolonging activities of Levofloxacin.
NelfinavirThe serum concentration of Nelfinavir can be increased when it is combined with Levofloxacin.
NeostigmineThe serum concentration of Levofloxacin can be increased when it is combined with Neostigmine.
NicardipineNicardipine may increase the QTc-prolonging activities of Levofloxacin.
NicardipineThe serum concentration of Nicardipine can be increased when it is combined with Levofloxacin.
NifedipineThe serum concentration of Levofloxacin can be decreased when it is combined with Nifedipine.
NifedipineThe serum concentration of Nifedipine can be increased when it is combined with Levofloxacin.
NilotinibLevofloxacin may increase the QTc-prolonging activities of Nilotinib.
NilotinibThe serum concentration of Levofloxacin can be increased when it is combined with Nilotinib.
NintedanibThe serum concentration of Nintedanib can be increased when it is combined with Levofloxacin.
NisoldipineThe serum concentration of Levofloxacin can be increased when it is combined with Nisoldipine.
NitrazepamThe serum concentration of Levofloxacin can be increased when it is combined with Nitrazepam.
NitrendipineThe serum concentration of Levofloxacin can be increased when it is combined with Nitrendipine.
NizatidineThe serum concentration of Nizatidine can be increased when it is combined with Levofloxacin.
NorethisteroneThe serum concentration of Levofloxacin can be decreased when it is combined with Norethisterone.
NorfloxacinNorfloxacin may increase the QTc-prolonging activities of Levofloxacin.
NortriptylineNortriptyline may increase the QTc-prolonging activities of Levofloxacin.
OctreotideOctreotide may increase the QTc-prolonging activities of Levofloxacin.
OfloxacinLevofloxacin may increase the QTc-prolonging activities of Ofloxacin.
OlanzapineOlanzapine may increase the QTc-prolonging activities of Levofloxacin.
OlanzapineThe serum concentration of Olanzapine can be increased when it is combined with Levofloxacin.
OlodaterolOlodaterol may increase the QTc-prolonging activities of Levofloxacin.
OmbitasvirThe serum concentration of Ombitasvir can be increased when it is combined with Levofloxacin.
OmeprazoleThe serum concentration of Levofloxacin can be increased when it is combined with Omeprazole.
OndansetronOndansetron may increase the QTc-prolonging activities of Levofloxacin.
OsimertinibThe serum concentration of Osimertinib can be increased when it is combined with Levofloxacin.
OuabainOuabain may decrease the cardiotoxic activities of Levofloxacin.
OxytocinOxytocin may increase the QTc-prolonging activities of Levofloxacin.
P-NitrophenolThe serum concentration of Levofloxacin can be increased when it is combined with P-Nitrophenol.
PaclitaxelThe serum concentration of Levofloxacin can be increased when it is combined with Paclitaxel.
PaliperidoneLevofloxacin may increase the QTc-prolonging activities of Paliperidone.
Palmitic AcidThe serum concentration of Levofloxacin can be increased when it is combined with Palmitic Acid.
PanobinostatPanobinostat may increase the QTc-prolonging activities of Levofloxacin.
PanobinostatThe serum concentration of Panobinostat can be increased when it is combined with Levofloxacin.
PantoprazoleThe serum concentration of Levofloxacin can be increased when it is combined with Pantoprazole.
ParoxetineParoxetine may increase the QTc-prolonging activities of Levofloxacin.
PasireotidePasireotide may increase the QTc-prolonging activities of Levofloxacin.
PazopanibThe serum concentration of Pazopanib can be increased when it is combined with Levofloxacin.
PazopanibPazopanib may increase the QTc-prolonging activities of Levofloxacin.
PentamidinePentamidine may increase the QTc-prolonging activities of Levofloxacin.
PerflutrenPerflutren may increase the QTc-prolonging activities of Levofloxacin.
PerindoprilThe serum concentration of Levofloxacin can be increased when it is combined with Perindopril.
PhenobarbitalThe serum concentration of Levofloxacin can be decreased when it is combined with Phenobarbital.
PhenobarbitalThe serum concentration of Phenobarbital can be increased when it is combined with Levofloxacin.
PhenytoinThe serum concentration of Phenytoin can be increased when it is combined with Levofloxacin.
Picosulfuric acidThe therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Levofloxacin.
PimozideLevofloxacin may increase the QTc-prolonging activities of Pimozide.
PimozideThe serum concentration of Levofloxacin can be increased when it is combined with Pimozide.
PitavastatinThe serum concentration of Pitavastatin can be increased when it is combined with Levofloxacin.
Platelet Activating FactorThe serum concentration of Levofloxacin can be decreased when it is combined with Platelet Activating Factor.
PomalidomideThe serum concentration of Pomalidomide can be increased when it is combined with Levofloxacin.
PonatinibThe serum concentration of Ponatinib can be increased when it is combined with Levofloxacin.
PosaconazolePosaconazole may increase the QTc-prolonging activities of Levofloxacin.
PravastatinThe serum concentration of Pravastatin can be increased when it is combined with Levofloxacin.
PrazosinThe serum concentration of Levofloxacin can be increased when it is combined with Prazosin.
PrednisoloneThe serum concentration of Prednisolone can be increased when it is combined with Levofloxacin.
PrednisoneThe serum concentration of Prednisone can be increased when it is combined with Levofloxacin.
PrimaquinePrimaquine may increase the QTc-prolonging activities of Levofloxacin.
ProbenecidThe serum concentration of Levofloxacin can be increased when it is combined with Probenecid.
ProcainamideLevofloxacin may increase the QTc-prolonging activities of Procainamide.
ProgesteroneThe serum concentration of Levofloxacin can be decreased when it is combined with Progesterone.
ProgesteroneThe serum concentration of Progesterone can be increased when it is combined with Levofloxacin.
PromazinePromazine may increase the QTc-prolonging activities of Levofloxacin.
PromethazinePromethazine may increase the QTc-prolonging activities of Levofloxacin.
PropafenoneLevofloxacin may increase the QTc-prolonging activities of Propafenone.
PropafenoneThe serum concentration of Levofloxacin can be increased when it is combined with Propafenone.
PropofolPropofol may increase the QTc-prolonging activities of Levofloxacin.
PropranololThe serum concentration of Propranolol can be increased when it is combined with Levofloxacin.
ProtriptylineProtriptyline may increase the QTc-prolonging activities of Levofloxacin.
PrucaloprideThe serum concentration of Prucalopride can be increased when it is combined with Levofloxacin.
QuercetinThe serum concentration of Levofloxacin can be increased when it is combined with Quercetin.
QuetiapineLevofloxacin may increase the QTc-prolonging activities of Quetiapine.
QuinacrineThe serum concentration of Levofloxacin can be increased when it is combined with Quinacrine.
QuinidineLevofloxacin may increase the QTc-prolonging activities of Quinidine.
QuinidineThe serum concentration of Levofloxacin can be increased when it is combined with Quinidine.
QuinineLevofloxacin may increase the QTc-prolonging activities of Quinine.
QuinineThe serum concentration of Levofloxacin can be increased when it is combined with Quinine.
RanitidineThe serum concentration of Levofloxacin can be increased when it is combined with Ranitidine.
RanolazineThe serum concentration of Ranolazine can be increased when it is combined with Levofloxacin.
ReboxetineThe serum concentration of Levofloxacin can be increased when it is combined with Reboxetine.
RegorafenibThe serum concentration of Levofloxacin can be increased when it is combined with Regorafenib.
ReserpineThe serum concentration of Levofloxacin can be decreased when it is combined with Reserpine.
ReserpineThe serum concentration of Reserpine can be increased when it is combined with Levofloxacin.
RifampicinThe serum concentration of Levofloxacin can be decreased when it is combined with Rifampicin.
RifampicinThe serum concentration of Rifampicin can be increased when it is combined with Levofloxacin.
RifaximinThe serum concentration of Rifaximin can be increased when it is combined with Levofloxacin.
RilpivirineRilpivirine may increase the QTc-prolonging activities of Levofloxacin.
RisperidoneRisperidone may increase the QTc-prolonging activities of Levofloxacin.
RisperidoneThe serum concentration of Risperidone can be increased when it is combined with Levofloxacin.
RitonavirRitonavir may increase the QTc-prolonging activities of Levofloxacin.
RitonavirThe serum concentration of Ritonavir can be increased when it is combined with Levofloxacin.
RivaroxabanThe serum concentration of Rivaroxaban can be increased when it is combined with Levofloxacin.
RolapitantThe serum concentration of Levofloxacin can be increased when it is combined with Rolapitant.
RomidepsinThe serum concentration of Romidepsin can be increased when it is combined with Levofloxacin.
SalbutamolSalbutamol may increase the QTc-prolonging activities of Levofloxacin.
Salicylic acidThe serum concentration of Salicylic acid can be increased when it is combined with Levofloxacin.
SalmeterolSalmeterol may increase the QTc-prolonging activities of Levofloxacin.
SaquinavirThe serum concentration of Levofloxacin can be decreased when it is combined with Saquinavir.
SaquinavirThe serum concentration of Saquinavir can be increased when it is combined with Levofloxacin.
ScopolamineThe serum concentration of Levofloxacin can be increased when it is combined with Scopolamine.
SelegilineThe serum concentration of Levofloxacin can be increased when it is combined with Selegiline.
SelexipagThe serum concentration of Selexipag can be increased when it is combined with Levofloxacin.
SertralineSertraline may increase the QTc-prolonging activities of Levofloxacin.
SevofluraneSevoflurane may increase the QTc-prolonging activities of Levofloxacin.
SilodosinThe serum concentration of Silodosin can be increased when it is combined with Levofloxacin.
SimeprevirThe serum concentration of Simeprevir can be increased when it is combined with Levofloxacin.
SimvastatinThe serum concentration of Levofloxacin can be increased when it is combined with Simvastatin.
SirolimusThe serum concentration of Levofloxacin can be decreased when it is combined with Sirolimus.
SitagliptinThe serum concentration of Sitagliptin can be increased when it is combined with Levofloxacin.
SofosbuvirThe serum concentration of Sofosbuvir can be increased when it is combined with Levofloxacin.
SolifenacinSolifenacin may increase the QTc-prolonging activities of Levofloxacin.
SorafenibSorafenib may increase the QTc-prolonging activities of Levofloxacin.
SorafenibThe serum concentration of Sorafenib can be increased when it is combined with Levofloxacin.
SotalolLevofloxacin may increase the QTc-prolonging activities of Sotalol.
SparfloxacinThe serum concentration of Sparfloxacin can be increased when it is combined with Levofloxacin.
SphingosineThe serum concentration of Sphingosine can be increased when it is combined with Levofloxacin.
SpironolactoneThe serum concentration of Levofloxacin can be increased when it is combined with Spironolactone.
St. John's WortThe serum concentration of Levofloxacin can be decreased when it is combined with St. John's Wort.
StaurosporineThe serum concentration of Levofloxacin can be increased when it is combined with Staurosporine.
StreptozocinThe serum concentration of Levofloxacin can be decreased when it is combined with Streptozocin.
SulfamethoxazoleSulfamethoxazole may increase the QTc-prolonging activities of Levofloxacin.
SulfinpyrazoneThe serum concentration of Levofloxacin can be increased when it is combined with Sulfinpyrazone.
SulfisoxazoleSulfisoxazole may increase the QTc-prolonging activities of Levofloxacin.
SumatriptanThe serum concentration of Levofloxacin can be increased when it is combined with Sumatriptan.
SunitinibSunitinib may increase the QTc-prolonging activities of Levofloxacin.
TacrineThe serum concentration of Levofloxacin can be increased when it is combined with Tacrine.
TacrolimusLevofloxacin may increase the QTc-prolonging activities of Tacrolimus.
TacrolimusThe serum concentration of Levofloxacin can be decreased when it is combined with Tacrolimus.
TamoxifenTamoxifen may increase the QTc-prolonging activities of Levofloxacin.
TamoxifenThe serum concentration of Tamoxifen can be increased when it is combined with Levofloxacin.
Taurocholic AcidThe serum concentration of Levofloxacin can be increased when it is combined with Taurocholic Acid.
Technetium Tc-99m sestamibiThe serum concentration of Technetium Tc-99m sestamibi can be increased when it is combined with Levofloxacin.
TelaprevirThe serum concentration of Telaprevir can be increased when it is combined with Levofloxacin.
TelavancinLevofloxacin may increase the QTc-prolonging activities of Telavancin.
TelithromycinTelithromycin may increase the QTc-prolonging activities of Levofloxacin.
TelmisartanThe serum concentration of Levofloxacin can be increased when it is combined with Telmisartan.
TemsirolimusThe serum concentration of Temsirolimus can be increased when it is combined with Levofloxacin.
TerazosinThe serum concentration of Levofloxacin can be increased when it is combined with Terazosin.
TerbutalineTerbutaline may increase the QTc-prolonging activities of Levofloxacin.
TerfenadineThe serum concentration of Levofloxacin can be increased when it is combined with Terfenadine.
TeriflunomideThe serum concentration of Levofloxacin can be increased when it is combined with Teriflunomide.
TesmilifeneThe serum concentration of Levofloxacin can be decreased when it is combined with Tesmilifene.
TestosteroneThe serum concentration of Levofloxacin can be increased when it is combined with Testosterone.
TetrabenazineLevofloxacin may increase the QTc-prolonging activities of Tetrabenazine.
ThioridazineLevofloxacin may increase the QTc-prolonging activities of Thioridazine.
ThiothixeneThiothixene may increase the QTc-prolonging activities of Levofloxacin.
TicagrelorThe serum concentration of Ticagrelor can be increased when it is combined with Levofloxacin.
TimololThe serum concentration of Timolol can be increased when it is combined with Levofloxacin.
TizanidineTizanidine may increase the QTc-prolonging activities of Levofloxacin.
TolterodineTolterodine may increase the QTc-prolonging activities of Levofloxacin.
TolvaptanThe serum concentration of Tolvaptan can be increased when it is combined with Levofloxacin.
TopotecanThe serum concentration of Topotecan can be increased when it is combined with Levofloxacin.
ToremifeneLevofloxacin may increase the QTc-prolonging activities of Toremifene.
TrastuzumabTrastuzumab may increase the cardiotoxic activities of Levofloxacin.
Trastuzumab emtansineThe serum concentration of Trastuzumab emtansine can be increased when it is combined with Levofloxacin.
TrazodoneTrazodone may increase the QTc-prolonging activities of Levofloxacin.
TreprostinilTreprostinil may increase the QTc-prolonging activities of Levofloxacin.
TrifluoperazineThe serum concentration of Levofloxacin can be increased when it is combined with Trifluoperazine.
TriflupromazineThe serum concentration of Levofloxacin can be increased when it is combined with Triflupromazine.
TrimethoprimTrimethoprim may increase the QTc-prolonging activities of Levofloxacin.
TrimipramineTrimipramine may increase the QTc-prolonging activities of Levofloxacin.
TriptorelinTriptorelin may increase the QTc-prolonging activities of Levofloxacin.
TroleandomycinThe serum concentration of Levofloxacin can be increased when it is combined with Troleandomycin.
UlipristalThe serum concentration of Ulipristal can be increased when it is combined with Levofloxacin.
UmeclidiniumThe serum concentration of Umeclidinium can be increased when it is combined with Levofloxacin.
VandetanibLevofloxacin may increase the QTc-prolonging activities of Vandetanib.
VardenafilVardenafil may increase the QTc-prolonging activities of Levofloxacin.
VecuroniumThe serum concentration of Vecuronium can be increased when it is combined with Levofloxacin.
VemurafenibLevofloxacin may increase the QTc-prolonging activities of Vemurafenib.
VenlafaxineVenlafaxine may increase the QTc-prolonging activities of Levofloxacin.
VenlafaxineThe serum concentration of Venlafaxine can be increased when it is combined with Levofloxacin.
VerapamilThe serum concentration of Levofloxacin can be decreased when it is combined with Verapamil.
VerapamilThe serum concentration of Verapamil can be increased when it is combined with Levofloxacin.
VilanterolVilanterol may increase the QTc-prolonging activities of Levofloxacin.
VinblastineThe serum concentration of Levofloxacin can be decreased when it is combined with Vinblastine.
VinblastineThe serum concentration of Vinblastine can be increased when it is combined with Levofloxacin.
VincristineThe serum concentration of Vincristine can be increased when it is combined with Levofloxacin.
VincristineThe serum concentration of Levofloxacin can be decreased when it is combined with Vincristine.
VinorelbineThe serum concentration of Levofloxacin can be increased when it is combined with Vinorelbine.
VismodegibThe serum concentration of Vismodegib can be increased when it is combined with Levofloxacin.
VoriconazoleVoriconazole may increase the QTc-prolonging activities of Levofloxacin.
VorinostatVorinostat may increase the QTc-prolonging activities of Levofloxacin.
ZidovudineThe serum concentration of Zidovudine can be increased when it is combined with Levofloxacin.
ZimelidineThe serum concentration of Levofloxacin can be increased when it is combined with Zimelidine.
ZiprasidoneLevofloxacin may increase the QTc-prolonging activities of Ziprasidone.
ZuclopenthixolLevofloxacin may increase the QTc-prolonging activities of Zuclopenthixol.
Food Interactions
  • Take without regard to meals. Take with water, drink lliberally. Taking this product with orange juice can result in reduced quinolone plasma levels.

Targets

Kind
Protein
Organism
Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Pharmacological action
yes
Actions
inhibitor
General Function:
Dna topoisomerase type ii (atp-hydrolyzing) activity
Specific Function:
DNA gyrase negatively supercoils closed circular double-stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings.
Gene Name:
gyrA
Uniprot ID:
P43700
Molecular Weight:
97817.145 Da
References
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284 ]
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423 ]
  3. Schmitz FJ, Hofmann B, Hansen B, Scheuring S, Luckefahr M, Klootwijk M, Verhoef J, Fluit A, Heinz HP, Kohrer K, Jones ME: Relationship between ciprofloxacin, ofloxacin, levofloxacin, sparfloxacin and moxifloxacin (BAY 12-8039) MICs and mutations in grlA, grlB, gyrA and gyrB in 116 unrelated clinical isolates of Staphylococcus aureus. J Antimicrob Chemother. 1998 Apr;41(4):481-4. [PubMed:9598779 ]
  4. Brisse S, Milatovic D, Fluit AC, Verhoef J, Martin N, Scheuring S, Kohrer K, Schmitz FJ: Comparative in vitro activities of ciprofloxacin, clinafloxacin, gatifloxacin, levofloxacin, moxifloxacin, and trovafloxacin against Klebsiella pneumoniae, Klebsiella oxytoca, Enterobacter cloacae, and Enterobacter aerogenes clinical isolates with alterations in GyrA and ParC proteins. Antimicrob Agents Chemother. 1999 Aug;43(8):2051-5. [PubMed:10428935 ]
  5. Messina C, Cafiso V, Campanile F, Santagati M, Stefani S: Rapid method for detection of gyrA and grlA mutations in unrelated strains of Staphylococci susceptible and resistant to levofloxacin. New Microbiol. 2001 Oct;24(4):347-53. [PubMed:11718372 ]
Kind
Protein
Organism
Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Pharmacological action
yes
Actions
inhibitor
General Function:
Dna topoisomerase type ii (atp-hydrolyzing) activity
Specific Function:
Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule.
Gene Name:
parC
Uniprot ID:
P43702
Molecular Weight:
83366.24 Da
References
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284 ]
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423 ]
  3. Zheng X, Johnson C, Lu Y, Yanagihara R, Hollingshead S, Crain M, Benjamin W Jr, Waites KB: Clinical isolates of Streptococcus pneumoniae resistant to levofloxacin contain mutations in both gyrA and parC genes. Int J Antimicrob Agents. 2001 Oct;18(4):373-8. [PubMed:11691571 ]
  4. Schafer J, Hovde LB, Simonson D, Rotschafer JC: In vitro pharmacodynamics of moxifloxacin versus levofloxacin against 4 strains of Streptococcus pneumoniae: 1 wild type, 2 first-step parC mutants, and 1 pump mutant. Diagn Microbiol Infect Dis. 2008 Feb;60(2):155-61. Epub 2007 Oct 29. [PubMed:17910998 ]
  5. Deryke CA, Du X, Nicolau DP: Evaluation of bacterial kill when modelling the bronchopulmonary pharmacokinetic profile of moxifloxacin and levofloxacin against parC-containing isolates of Streptococcus pneumoniae. J Antimicrob Chemother. 2006 Sep;58(3):601-9. Epub 2006 Jul 19. [PubMed:16857688 ]
Kind
Protein
Organism
Human
Pharmacological action
yes
Actions
inhibitor
General Function:
Ubiquitin binding
Specific Function:
Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double-strand breaks. Essential during mitosis and meiosis for proper segregation of daughter chromosomes. May play a role in regulating the period length of ARNTL/BMAL1 transcriptional oscillation (By similarity).
Gene Name:
TOP2A
Uniprot ID:
P11388
Molecular Weight:
174383.88 Da
References
  1. Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. [PubMed:11752352 ]

Enzymes

Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. Most active in catalyzing 2-hydroxylation. Caffeine is metabolized primarily by cytochrome CYP1A2 in the liver through an initial N...
Gene Name:
CYP1A2
Uniprot ID:
P05177
Molecular Weight:
58293.76 Da
References
  1. Bellon A, Perez-Garcia G, Coverdale JH, Chacko RC: Seizures associated with levofloxacin: case presentation and literature review. Eur J Clin Pharmacol. 2009 Oct;65(10):959-62. doi: 10.1007/s00228-009-0717-5. Epub 2009 Aug 26. [PubMed:19707748 ]
  2. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Vitamin d3 25-hydroxylase activity
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It performs a variety of oxidation reactions (e.g. caffeine 8-oxidation, omeprazole sulphoxidation, midazolam 1'-hydroxylation and midazolam 4-hydroxylation) of structurally unrelated compounds, including steroids, fatty acids, and xenobiot...
Gene Name:
CYP3A4
Uniprot ID:
P08684
Molecular Weight:
57342.67 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]

Transporters

Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrateinhibitor
General Function:
Xenobiotic-transporting atpase activity
Specific Function:
Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells.
Gene Name:
ABCB1
Uniprot ID:
P08183
Molecular Weight:
141477.255 Da
References
  1. Ito T, Yano I, Tanaka K, Inui KI: Transport of quinolone antibacterial drugs by human P-glycoprotein expressed in a kidney epithelial cell line, LLC-PK1. J Pharmacol Exp Ther. 1997 Aug;282(2):955-60. [PubMed:9262363 ]
  2. Yamaguchi H, Yano I, Hashimoto Y, Inui KI: Secretory mechanisms of grepafloxacin and levofloxacin in the human intestinal cell line caco-2. J Pharmacol Exp Ther. 2000 Oct;295(1):360-6. [PubMed:10992002 ]
  3. Yamaguchi H, Yano I, Saito H, Inui K: Effect of cisplatin-induced acute renal failure on bioavailability and intestinal secretion of quinolone antibacterial drugs in rats. Pharm Res. 2004 Feb;21(2):330-8. [PubMed:15032316 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrate
General Function:
Sodium-independent organic anion transmembrane transporter activity
Specific Function:
Involved in the renal elimination of endogenous and exogenous organic anions. Functions as organic anion exchanger when the uptake of one molecule of organic anion is coupled with an efflux of one molecule of endogenous dicarboxylic acid (glutarate, ketoglutarate, etc). Mediates the sodium-independent uptake of 2,3-dimercapto-1-propanesulfonic acid (DMPS) (By similarity). Mediates the sodium-in...
Gene Name:
SLC22A6
Uniprot ID:
Q4U2R8
Molecular Weight:
61815.78 Da
References
  1. Uwai Y, Okuda M, Takami K, Hashimoto Y, Inui K: Functional characterization of the rat multispecific organic anion transporter OAT1 mediating basolateral uptake of anionic drugs in the kidney. FEBS Lett. 1998 Nov 6;438(3):321-4. [PubMed:9827570 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Quaternary ammonium group transmembrane transporter activity
Specific Function:
Mediates tubular uptake of organic compounds from circulation. Mediates the influx of agmatine, dopamine, noradrenaline (norepinephrine), serotonin, choline, famotidine, ranitidine, histamin, creatinine, amantadine, memantine, acriflavine, 4-[4-(dimethylamino)-styryl]-N-methylpyridinium ASP, amiloride, metformin, N-1-methylnicotinamide (NMN), tetraethylammonium (TEA), 1-methyl-4-phenylpyridiniu...
Gene Name:
SLC22A2
Uniprot ID:
O15244
Molecular Weight:
62579.99 Da
References
  1. Urakami Y, Akazawa M, Saito H, Okuda M, Inui K: cDNA cloning, functional characterization, and tissue distribution of an alternatively spliced variant of organic cation transporter hOCT2 predominantly expressed in the human kidney. J Am Soc Nephrol. 2002 Jul;13(7):1703-10. [PubMed:12089365 ]
  2. Okuda M, Urakami Y, Saito H, Inui K: Molecular mechanisms of organic cation transport in OCT2-expressing Xenopus oocytes. Biochim Biophys Acta. 1999 Mar 4;1417(2):224-31. [PubMed:10082798 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Symporter activity
Specific Function:
Sodium-ion dependent, low affinity carnitine transporter. Probably transports one sodium ion with one molecule of carnitine. Also transports organic cations such as tetraethylammonium (TEA) without the involvement of sodium. Relative uptake activity ratio of carnitine to TEA is 1.78. A key substrate of this transporter seems to be ergothioneine (ET).
Gene Name:
SLC22A4
Uniprot ID:
Q9H015
Molecular Weight:
62154.48 Da
References
  1. Yabuuchi H, Tamai I, Nezu J, Sakamoto K, Oku A, Shimane M, Sai Y, Tsuji A: Novel membrane transporter OCTN1 mediates multispecific, bidirectional, and pH-dependent transport of organic cations. J Pharmacol Exp Ther. 1999 May;289(2):768-73. [PubMed:10215651 ]
Comments
comments powered by Disqus
Drug created on June 13, 2005 07:24 / Updated on September 25, 2016 03:31