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Identification
NameBupropion
Accession NumberDB01156  (APRD00621)
TypeSmall Molecule
GroupsApproved
Description

A unicyclic, aminoketone antidepressant. The mechanism of its therapeutic actions is not well understood, but it does appear to block dopamine uptake. The hydrochloride is available as an aid to smoking cessation treatment. [PubChem]

Structure
Thumb
Synonyms
Amfebutamone
External Identifiers
  • 34841-39-9
Approved Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Act Bupropion XLtablet (extended-release)300 mgoralActavis Pharma CompanyNot applicableNot applicableCanada
Act Bupropion XLtablet (extended-release)150 mgoralActavis Pharma CompanyNot applicableNot applicableCanada
Aplenzintablet, extended release174 mg/1oralSanofi Aventis U.S. Llc2009-03-30Not applicableUs
Aplenzintablet, extended release522 mg/1oralValeant Pharmaceuticals North America LLC2009-03-30Not applicableUs
Aplenzintablet, extended release348 mg/1oralValeant Pharmaceuticals North America LLC2009-03-30Not applicableUs
Aplenzintablet, extended release174 mg/1oralValeant Pharmaceuticals North America LLC2009-03-30Not applicableUs
Aplenzintablet, extended release522 mg/1oralSanofi Aventis U.S. Llc2009-03-30Not applicableUs
Aplenzintablet, extended release348 mg/1oralSanofi Aventis U.S. Llc2009-03-30Not applicableUs
Aplenzin ERtablet, extended release348 mg/1oralSTAT Rx USA LLC2009-03-30Not applicableUs
Ava-bupropion SRtablet (extended-release)150 mgoralAvanstra Inc2011-09-192014-08-21Canada
Ava-bupropion SRtablet (extended-release)100 mgoralAvanstra Inc2011-09-192014-08-21Canada
Bupropion HCl SRtablet (extended-release)150 mgoralValeant Canada Lp Valeant Canada S.E.C.Not applicableNot applicableCanada
Bupropion HCl XLtablet (extended-release)300 mgoralValeant Canada Lp Valeant Canada S.E.C.Not applicableNot applicableCanada
Bupropion HCl XLtablet (extended-release)150 mgoralValeant Canada Lp Valeant Canada S.E.C.Not applicableNot applicableCanada
Bupropion SRtablet (extended-release)100 mgoralSanis Health Inc2012-10-01Not applicableCanada
Bupropion SRtablet (extended-release)100 mgoralPro Doc Limitee2010-02-03Not applicableCanada
Bupropion SRtablet (extended-release)150 mgoralPro Doc Limitee2009-06-22Not applicableCanada
Bupropion SRtablet (extended-release)150 mgoralSanis Health Inc2012-10-01Not applicableCanada
Dom-bupropion SRtablet (extended-release)100 mgoralDominion PharmacalNot applicableNot applicableCanada
Dom-bupropion SRtablet (extended-release)150 mgoralDominion PharmacalNot applicableNot applicableCanada
Forfivo XLtablet, film coated, extended release450 mg/1oralEdgemont Pharmaceuticals, Llc2012-10-01Not applicableUs
Mylan-bupropion XLtablet (extended-release)300 mgoralMylan Pharmaceuticals Ulc2013-09-17Not applicableCanada
Mylan-bupropion XLtablet (extended-release)150 mgoralMylan Pharmaceuticals Ulc2013-09-17Not applicableCanada
Novo-bupropion SRtablet (extended-release)100 mgoralNovopharm LimitedNot applicableNot applicableCanada
Novo-bupropion SR Tabletstablet (extended-release)150 mgoralNovopharm Limited2005-03-302015-10-26Canada
PHL-bupropion SRtablet (extended-release)150 mgoralPharmel IncNot applicableNot applicableCanada
PMS-bupropion SRtablet (extended-release)100 mgoralPharmascience Inc2009-05-11Not applicableCanada
PMS-bupropion SRtablet (extended-release)150 mgoralPharmascience Inc2008-09-09Not applicableCanada
Ratio-bupropion SRtablet (extended-release)100 mgoralTeva Canada Limited2006-11-20Not applicableCanada
Ratio-bupropion SRtablet (extended-release)150 mgoralTeva Canada Limited2006-11-20Not applicableCanada
Sandoz Bupropion SRtablet (extended-release)150 mgoralSandoz Canada Incorporated2006-06-23Not applicableCanada
Sandoz Bupropion SRtablet (extended-release)100 mgoralSandoz Canada Incorporated2006-06-23Not applicableCanada
Wellbutrintablet, film coated75 mg/1oralREMEDYREPACK INC.2014-12-09Not applicableUs
Wellbutrintablet, film coated100 mg/1oralGlaxo Smith Kline Llc1989-06-21Not applicableUs
Wellbutrintablet, film coated75 mg/1oralGlaxo Smith Kline Llc1986-02-04Not applicableUs
Wellbutrintablet, film coated100 mg/1oralREMEDYREPACK INC.2014-01-30Not applicableUs
Wellbutrin SRtablet, film coated100 mg/1oralGlaxo Smith Kline Llc1996-11-15Not applicableUs
Wellbutrin SRtablet, film coated200 mg/1oralGlaxo Smith Kline Llc2002-06-25Not applicableUs
Wellbutrin SRtablet (extended-release)150 mgoralValeant Canada Lp Valeant Canada S.E.C.1998-05-05Not applicableCanada
Wellbutrin SRtablet, film coated150 mg/1oralGlaxo Smith Kline Llc1996-11-15Not applicableUs
Wellbutrin SRtablet (extended-release)100 mgoralBiovail Pharmaceuticals Canada Division Of Biovail Corporation1998-05-052008-11-14Canada
Wellbutrin XLtablet (extended-release)300 mgoralValeant Canada Lp Valeant Canada S.E.C.2006-02-02Not applicableCanada
Wellbutrin XLtablet, extended release300 mg/1oralRebel Distributors Corp2009-12-23Not applicableUs
Wellbutrin XLtablet, extended release150 mg/1oralRebel Distributors Corp2009-12-23Not applicableUs
Wellbutrin XLtablet (extended-release)150 mgoralValeant Canada Lp Valeant Canada S.E.C.2006-02-02Not applicableCanada
Wellbutrin XLtablet, extended release150 mg/1oralLake Erie Medical DBA Quality Care Products LLC2009-12-23Not applicableUs
Wellbutrin XLtablet, extended release300 mg/1oralSTAT Rx USA LLC2009-12-23Not applicableUs
Wellbutrin XLtablet, extended release150 mg/1oralPhysicians Total Care, Inc.2004-03-02Not applicableUs
Wellbutrin XLtablet, extended release300 mg/1oralPhysicians Total Care, Inc.2003-10-08Not applicableUs
Wellbutrin XLtablet, extended release150 mg/1oralLake Erie Medical & Surgical Supply DBA Quality Care Products LLC2012-03-20Not applicableUs
Wellbutrin XLtablet, extended release300 mg/1oralValeant Pharmaceuticals North America LLC2003-08-29Not applicableUs
Wellbutrin XLtablet, extended release150 mg/1oralValeant Pharmaceuticals North America LLC2003-08-29Not applicableUs
Wellbutrin XL XLtablet, extended release150 mg/1oralREMEDYREPACK INC.2014-04-25Not applicableUs
Wellbutrinxl XLtablet, extended release150 mg/1oralREMEDYREPACK INC.2015-10-20Not applicableUs
Wellbutrinxl XLtablet, extended release300 mg/1oralREMEDYREPACK INC.2015-10-20Not applicableUs
Zybantablet, film coated150 mg/1oralGlaxo Smith Kline Llc1997-05-28Not applicableUs
Zybantablet (extended-release)150 mgoralValeant Canada Lp Valeant Canada S.E.C.1998-08-10Not applicableCanada
Approved Generic Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Budepriontablet, extended release150 mg/1oralbryant ranch prepack2008-05-30Not applicableUs
Budeprion SRtablet, extended release150 mg/1oralbryant ranch prepack2004-03-23Not applicableUs
Budeprion SRtablet, extended release100 mg/1oralCardinal Health2004-01-28Not applicableUs
Budeprion SRtablet, extended release150 mg/1oralCardinal Health2004-03-22Not applicableUs
Budeprion XLtablet, film coated, extended release150 mg/1oralSTAT Rx USA LLC2006-12-14Not applicableUs
Budeprion XL XLtablet, film coated, extended release150 mg/1oralNcs Health Care Of Ky, Inc Dba Vangard Labs2006-12-14Not applicableUs
Buprobantablet, extended release150 mg/1oralTeva Pharmaceuticals USA Inc2004-05-27Not applicableUs
Bupropiontablet, extended release300 mg/1oralPreferred Pharmaceuticals, Inc.2014-11-03Not applicableUs
Bupropiontablet, extended release300 mg/1oralZydus Pharmaceuticals (USA) Inc.2014-02-15Not applicableUs
Bupropiontablet, extended release300 mg/1oralBlue Point Laboratories2014-10-03Not applicableUs
Bupropiontablet, extended release300 mg/1oralREMEDYREPACK INC.2015-07-22Not applicableUs
Bupropiontablet, extended release200 mg/1oralSolco Healthcare US LLC2014-11-01Not applicableUs
Bupropiontablet, extended release300 mg/1oralCadila Healthcare Limited2014-02-15Not applicableUs
Bupropiontablet, extended release150 mg/1oralBlue Point Laboratories2015-01-22Not applicableUs
Bupropiontablet, extended release150 mg/1oralSolco Healthcare US LLC2014-11-01Not applicableUs
Bupropiontablet, extended release100 mg/1oralSolco Healthcare US LLC2014-11-01Not applicableUs
Bupropiontablet, extended release300 mg/1oralProficient Rx LP2014-02-15Not applicableUs
Bupropion Hydrochloridetablet, film coated75 mg/1oralSandoz Inc2000-02-07Not applicableUs
Bupropion Hydrochloridetablet, film coated, extended release200 mg/1oralAphena Pharma Solutions Tennessee, Llc2009-07-02Not applicableUs
Bupropion Hydrochloridetablet, film coated75 mg/1oralNcs Health Care Of Ky, Inc Dba Vangard Labs2010-02-01Not applicableUs
Bupropion Hydrochloridetablet, film coated, extended release150 mg/1oralLake Erie Medical & Surgical Supply DBA Quality Care Products LLC2009-08-25Not applicableUs
Bupropion Hydrochloridetablet, film coated75 mg/1oralPd Rx Pharmaceuticals, Inc.2010-02-01Not applicableUs
Bupropion Hydrochloridetablet75 mg/1oralREMEDYREPACK INC.2011-03-11Not applicableUs
Bupropion Hydrochloridetablet, film coated, extended release150 mg/1oralREMEDYREPACK INC.2014-07-18Not applicableUs
Bupropion Hydrochloridetablet, film coated, extended release150 mg/1oralSun Pharma Global FZE2015-09-23Not applicableUs
Bupropion Hydrochloridetablet, film coated100 mg/1oralMylan Institutional Inc.2000-07-01Not applicableUs
Bupropion Hydrochloridetablet, extended release150 mg/1oralCardinal Health2009-01-05Not applicableUs
Bupropion Hydrochloridetablet, extended release150 mg/1oralRebel Distributors Corp.2009-09-01Not applicableUs
Bupropion Hydrochloridetablet, film coated100 mg/1oralUnit Dose Services2010-04-26Not applicableUs
Bupropion Hydrochloridetablet, film coated100 mg/1oralPhysicians Total Care, Inc.2004-05-19Not applicableUs
Bupropion Hydrochloridetablet, extended release150 mg/1oralTorrent Pharmaceuticals Limited2014-10-31Not applicableUs
Bupropion Hydrochloridetablet, film coated, extended release150 mg/1oralPd Rx Pharmaceuticals, Inc.2009-07-02Not applicableUs
Bupropion Hydrochloridetablet, film coated100 mg/1oralH.J. Harkins Company, Inc.2010-02-01Not applicableUs
Bupropion Hydrochloridetablet, film coated100 mg/1oralSandoz Inc2000-02-07Not applicableUs
Bupropion Hydrochloridetablet, film coated, extended release300 mg/1oralAidarex Pharmaceuticals LLC2007-06-12Not applicableUs
Bupropion Hydrochloridetablet, extended release100 mg/1oralREMEDYREPACK INC.2014-09-03Not applicableUs
Bupropion Hydrochloridetablet, film coated100 mg/1oralCardinal Health2010-02-10Not applicableUs
Bupropion Hydrochloridetablet, extended release200 mg/1oralRebel Distributors Corp.2009-09-01Not applicableUs
Bupropion Hydrochloridetablet, extended release150 mg/1oralAmerican Health Packaging2015-03-01Not applicableUs
Bupropion Hydrochloridetablet, extended release300 mg/1oralProficient Rx LP2010-03-31Not applicableUs
Bupropion Hydrochloridetablet, film coated, extended release150 mg/1oralDIRECT RX2014-01-01Not applicableUs
Bupropion Hydrochloridetablet, extended release150 mg/1oralREMEDYREPACK INC.2014-12-30Not applicableUs
Bupropion Hydrochloridetablet, film coated, extended release200 mg/1oralbryant ranch prepack2004-12-03Not applicableUs
Bupropion Hydrochloridetablet, film coated, extended release100 mg/1oralActavis South Atlantic LLC2010-07-19Not applicableUs
Bupropion Hydrochloridetablet, film coated75 mg/1oralProficient Rx LP2000-02-07Not applicableUs
Bupropion Hydrochloridetablet, film coated100 mg/1oralMylan Pharmaceuticals Inc.2000-05-11Not applicableUs
Bupropion Hydrochloridetablet, film coated100 mg/1oralContract Pharmacy Services Pa2010-02-24Not applicableUs
Bupropion Hydrochloridetablet, film coated, extended release100 mg/1oralTYA Pharmaceuticals2010-04-08Not applicableUs
Bupropion Hydrochloridetablet, film coated75 mg/1occlusive dressing techniqueDispensing Solutions, Inc.2000-02-07Not applicableUs
Bupropion Hydrochloridetablet, film coated100 mg/1oralBlue Point Laboratories2014-02-07Not applicableUs
Bupropion Hydrochloridetablet, film coated, extended release150 mg/1oralAv Kare, Inc.2016-01-27Not applicableUs
Bupropion Hydrochloridetablet, film coated, extended release150 mg/1oralPreferred Pharmaceuticals, Inc.2014-09-08Not applicableUs
Bupropion Hydrochloridetablet, film coated, extended release100 mg/1oralSun Pharma Global FZE2015-09-23Not applicableUs
Bupropion Hydrochloridetablet, film coated75 mg/1oralMylan Institutional Inc.2000-07-01Not applicableUs
Bupropion Hydrochloridetablet, film coated100 mg/1oralCardinal Health2000-05-11Not applicableUs
Bupropion Hydrochloridetablet, film coated100 mg/1oralRebel Distributors Corp.2000-02-07Not applicableUs
Bupropion Hydrochloridetablet, film coated75 mg/1oralPhysicians Total Care, Inc.2004-05-04Not applicableUs
Bupropion Hydrochloridetablet, extended release100 mg/1oralTorrent Pharmaceuticals Limited2014-10-31Not applicableUs
Bupropion Hydrochloridetablet, film coated, extended release200 mg/1oralJubilant Cadista Pharmaceuticals Inc.2013-10-11Not applicableUs
Bupropion Hydrochloridetablet, film coated, extended release200 mg/1oralPd Rx Pharmaceuticals, Inc.2010-04-08Not applicableUs
Bupropion Hydrochloridetablet, film coated, extended release100 mg/1oralREMEDYREPACK INC.2014-08-26Not applicableUs
Bupropion Hydrochloridetablet, film coated75 mg/1oralApotex Corp2006-01-17Not applicableUs
Bupropion Hydrochloridetablet, film coated, extended release200 mg/1oralProficient Rx LP2010-04-08Not applicableUs
Bupropion Hydrochloridetablet75 mg/1oralDIRECT RX2015-11-25Not applicableUs
Bupropion Hydrochloridetablet, extended release300 mg/1oralActavis South Atlantic LLC2010-03-31Not applicableUs
Bupropion Hydrochloridetablet, film coated75 mg/1oralMylan Pharmaceuticals Inc.2000-05-11Not applicableUs
Bupropion Hydrochloridetablet, film coated75 mg/1oralContract Pharmacy Services Pa2010-02-24Not applicableUs
Bupropion Hydrochloridetablet, film coated, extended release150 mg/1oralPreferred Pharmaceuticals, Inc.2014-11-27Not applicableUs
Bupropion Hydrochloridetablet, film coated, extended release150 mg/1oralAmerican Health Packaging2015-04-01Not applicableUs
Bupropion Hydrochloridetablet, film coated, extended release200 mg/1oralImpax Generics2004-12-03Not applicableUs
Bupropion Hydrochloridetablet, film coated, extended release150 mg/1oralREMEDYREPACK INC.2016-01-05Not applicableUs
Bupropion Hydrochloridetablet, extended release300 mg/1oralActavis Pharma, Inc.2015-02-17Not applicableUs
Bupropion Hydrochloridetablet, film coated, extended release150 mg/1oralNcs Health Care Of Ky, Inc Dba Vangard Labs2007-06-12Not applicableUs
Bupropion Hydrochloridetablet, film coated100 mg/1oralAphena Pharma Solutions Tennessee, Llc2000-02-07Not applicableUs
Bupropion Hydrochloridetablet, film coated75 mg/1oralLake Erie Medical & Surgical Supply DBA Quality Care Products LLC2000-02-07Not applicableUs
Bupropion Hydrochloridetablet100 mg/1oralREMEDYREPACK INC.2011-08-18Not applicableUs
Bupropion Hydrochloridetablet, film coated, extended release150 mg/1oralREMEDYREPACK INC.2014-07-07Not applicableUs
Bupropion Hydrochloridetablet, film coated, extended release150 mg/1oralJubilant Cadista Pharmaceuticals Inc.2013-10-11Not applicableUs
Bupropion Hydrochloridetablet, film coated, extended release100 mg/1oralRebel Distributors Corp2009-07-02Not applicableUs
Bupropion Hydrochloridetablet, film coated100 mg/1oralAidarex Pharmaceuticals LLC2000-02-07Not applicableUs
Bupropion Hydrochloridetablet, film coated, extended release150 mg/1oralREMEDYREPACK INC.2014-08-07Not applicableUs
Bupropion Hydrochloridetablet, film coated100 mg/1oralApotex Corp2006-01-17Not applicableUs
Bupropion Hydrochloridetablet, film coated, extended release100 mg/1oralProficient Rx LP2010-04-08Not applicableUs
Bupropion Hydrochloridetablet, extended release150 mg/1oralREMEDYREPACK INC.2016-01-04Not applicableUs
Bupropion Hydrochloridetablet, film coated100 mg/1oralbryant ranch prepack2000-02-07Not applicableUs
Bupropion Hydrochloridetablet, film coated, extended release150 mg/1oralMylan Pharmaceuticals Inc.2010-05-14Not applicableUs
Bupropion Hydrochloridetablet, extended release150 mg/1oralActavis South Atlantic LLC2010-03-312016-01-31Us
Bupropion Hydrochloridetablet, extended release200 mg/1oralEon Labs, Inc.2005-06-22Not applicableUs
Bupropion Hydrochloridetablet, film coated100 mg/1oralContract Pharmacy Services Pa2002-07-02Not applicableUs
Bupropion Hydrochloridetablet, film coated, extended release150 mg/1oralPreferred Pharmaceuticals, Inc2011-06-29Not applicableUs
Bupropion Hydrochloridetablet, film coated, extended release100 mg/1oralAmerican Health Packaging2015-03-23Not applicableUs
Bupropion Hydrochloridetablet, film coated, extended release150 mg/1oralAmerican Health Packaging2011-07-012015-12-29Us
Bupropion Hydrochloridetablet, extended release150 mg/1oralActavis Pharma, Inc.2015-02-05Not applicableUs
Bupropion Hydrochloridetablet, film coated, extended release100 mg/1oralAphena Pharma Solutions Tennessee, Inc.2010-07-19Not applicableUs
Bupropion Hydrochloridetablet, extended release100 mg/1oralNcs Health Care Of Ky, Inc Dba Vangard Labs2009-07-02Not applicableUs
Bupropion Hydrochloridetablet100 mg/1oralREMEDYREPACK INC.2011-06-28Not applicableUs
Bupropion Hydrochloridetablet, extended release100 mg/1oralREMEDYREPACK INC.2014-03-19Not applicableUs
Bupropion Hydrochloridetablet, film coated, extended release150 mg/1oralMylan Institutional Inc.2010-05-28Not applicableUs
Bupropion Hydrochloridetablet, film coated, extended release150 mg/1occlusive dressing techniqueDispensing Solutions, Inc.2009-07-02Not applicableUs
Bupropion Hydrochloridetablet, film coated75 mg/1oralRebel Distributors Corp.2000-02-07Not applicableUs
Bupropion Hydrochloridetablet, film coated100 mg/1oralState of Florida DOH Central Pharmacy2009-07-01Not applicableUs
Bupropion Hydrochloridetablet, film coated, extended release150 mg/1oralAnchen Pharmaceuticals, Inc.2011-06-14Not applicableUs
Bupropion Hydrochloridetablet, film coated, extended release150 mg/1oralProficient Rx LP2014-01-27Not applicableUs
Bupropion Hydrochloridetablet, film coated, extended release100 mg/1oralREMEDYREPACK INC.2015-12-10Not applicableUs
Bupropion Hydrochloridetablet, film coated, extended release100 mg/1oralbryant ranch prepack2010-07-19Not applicableUs
Bupropion Hydrochloridetablet, film coated, extended release200 mg/1oralMylan Pharmaceuticals Inc.2010-04-09Not applicableUs
Bupropion Hydrochloridetablet, film coated, extended release200 mg/1oralActavis South Atlantic LLC2010-07-19Not applicableUs
Bupropion Hydrochloridetablet, extended release150 mg/1oralEon Labs, Inc.2004-03-22Not applicableUs
Bupropion Hydrochloridetablet, film coated75 mg/1oralContract Pharmacy Services Pa2002-08-02Not applicableUs
Bupropion Hydrochloridetablet, film coated, extended release150 mg/1oralPreferred Pharmaceuticals Inc.2015-09-22Not applicableUs
Bupropion Hydrochloridetablet, film coated, extended release300 mg/1oralAmerican Health Packaging2013-06-20Not applicableUs
Bupropion Hydrochloridetablet, film coated, extended release100 mg/1oralAmerican Health Packaging2011-07-012015-12-29Us
Bupropion Hydrochloridetablet, film coated, extended release150 mg/1oralMedsource Pharmaceuticals2010-04-08Not applicableUs
Bupropion Hydrochloridetablet, film coated100 mg/1oralNcs Health Care Of Ky, Inc Dba Vangard Labs2006-01-17Not applicableUs
Bupropion Hydrochloridetablet, film coated, extended release150 mg/1oralAphena Pharma Solutions Tennessee, Llc2009-07-02Not applicableUs
Bupropion Hydrochloridetablet, extended release150 mg/1oralNcs Health Care Of Ky, Inc Dba Vangard Labs2009-07-02Not applicableUs
Bupropion Hydrochloridetablet, extended release150 mg/1oralREMEDYREPACK INC.2012-03-05Not applicableUs
Bupropion Hydrochloridetablet, film coated, extended release150 mg/1oralREMEDYREPACK INC.2011-05-12Not applicableUs
Bupropion Hydrochloridetablet, film coated, extended release150 mg/1oralREMEDYREPACK INC.2014-01-30Not applicableUs
Bupropion Hydrochloridetablet, film coated, extended release100 mg/1oralMylan Institutional Inc.2010-05-28Not applicableUs
Bupropion Hydrochloridetablet, film coated75 mg/1oralState of Florida DOH Central Pharmacy2009-07-01Not applicableUs
Bupropion Hydrochloridetablet, film coated, extended release300 mg/1oralPar Pharmaceutical, Inc.2007-06-12Not applicableUs
Bupropion Hydrochloridetablet, film coated, extended release100 mg/1oralJubilant Cadista Pharmaceuticals Inc.2013-10-11Not applicableUs
Bupropion Hydrochloridetablet, film coated75 mg/1oralAidarex Pharmaceuticals LLC2000-02-07Not applicableUs
Bupropion Hydrochloridetablet, film coated100 mg/1oralSt Marys Medical Park Pharmacy2014-05-22Not applicableUs
Bupropion Hydrochloridetablet, film coated100 mg/1oralGolden State Medical Supply, Inc2010-02-01Not applicableUs
Bupropion Hydrochloridetablet, film coated, extended release150 mg/1oralMylan Pharmaceuticals Inc.2010-04-09Not applicableUs
Bupropion Hydrochloridetablet, film coated, extended release150 mg/1oralActavis South Atlantic LLC2008-03-12Not applicableUs
Bupropion Hydrochloridetablet, extended release100 mg/1oralEon Labs, Inc.2003-11-25Not applicableUs
Bupropion Hydrochloridetablet150 mg/1occlusive dressing techniqueDispensing Solutions, Inc.2008-03-12Not applicableUs
Bupropion Hydrochloridetablet, extended release150 mg/1oralAmerican Health Packaging2014-11-052015-12-31Us
Bupropion Hydrochloridetablet, film coated, extended release150 mg/1oralMedsource Pharmaceuticals2009-05-01Not applicableUs
Bupropion Hydrochloridetablet, film coated75 mg/1oralNcs Health Care Of Ky, Inc Dba Vangard Labs2006-01-17Not applicableUs
Bupropion Hydrochloridetablet, film coated, extended release100 mg/1oralAphena Pharma Solutions Tennessee, Llc2009-07-02Not applicableUs
Bupropion Hydrochloridetablet, film coated75 mg/1oralNcs Health Care Of Ky, Inc Dba Vangard Labs2000-02-07Not applicableUs
Bupropion Hydrochloridetablet100 mg/1oralREMEDYREPACK INC.2011-09-08Not applicableUs
Bupropion Hydrochloridetablet, extended release150 mg/1oralREMEDYREPACK INC.2013-05-23Not applicableUs
Bupropion Hydrochloridetablet, film coated, extended release300 mg/1oralMylan Institutional Inc.2011-07-18Not applicableUs
Bupropion Hydrochloridetablet, film coated, extended release150 mg/1oralSTAT Rx USA LLC2009-07-02Not applicableUs
Bupropion Hydrochloridetablet, film coated100 mg/1oralState of Florida DOH Central Pharmacy2009-07-01Not applicableUs
Bupropion Hydrochloridetablet, film coated, extended release150 mg/1oralPar Pharmaceutical, Inc.2007-06-12Not applicableUs
Bupropion Hydrochloridetablet, film coated, extended release150 mg/1oralJubilant Cadista Pharmaceuticals Inc.2013-10-11Not applicableUs
Bupropion Hydrochloridetablet, film coated100 mg/1oralPd Rx Pharmaceuticals, Inc.2010-02-01Not applicableUs
Bupropion Hydrochloridetablet100 mg/1oralREMEDYREPACK INC.2011-12-13Not applicableUs
Bupropion Hydrochloridetablet, film coated75 mg/1oralGolden State Medical Supply, Inc2010-02-01Not applicableUs
Bupropion Hydrochloridetablet, film coated, extended release150 mg/1oralProficient Rx LP2010-04-08Not applicableUs
Bupropion Hydrochloridetablet, extended release300 mg/1oralMc Kesson Packaging Services A Business Unit Of Mc Kesson Corporation2010-03-31Not applicableUs
Bupropion Hydrochloridetablet, film coated, extended release150 mg/1oralImpax Generics2009-05-01Not applicableUs
Bupropion Hydrochloridetablet, film coated100 mg/1oralPreferred Pharmaceuticals,Inc.2012-07-27Not applicableUs
Bupropion Hydrochloridetablet, film coated, extended release150 mg/1oralNcs Health Care Of Ky, Inc Dba Vangard Labs2008-03-12Not applicableUs
Bupropion Hydrochloridetablet, film coated100 mg/1oralNcs Health Care Of Ky, Inc Dba Vangard Labs2000-02-07Not applicableUs
Bupropion Hydrochloridetablet, extended release150 mg/1oralREMEDYREPACK INC.2011-08-25Not applicableUs
Bupropion Hydrochloridetablet, film coated, extended release100 mg/1oralREMEDYREPACK INC.2011-03-01Not applicableUs
Bupropion Hydrochloridetablet, film coated, extended release150 mg/1oralMylan Institutional Inc.2011-03-23Not applicableUs
Bupropion Hydrochloridetablet, film coated75 mg/1oralSTAT Rx USA LLC2010-02-01Not applicableUs
Bupropion Hydrochloridetablet, film coated100 mg/1oralState of Florida DOH Central Pharmacy2009-07-01Not applicableUs
Bupropion Hydrochloridetablet, film coated100 mg/1oralMajor Pharmaceuticals2010-04-26Not applicableUs
Bupropion Hydrochloridetablet, film coated, extended release150 mg/1oralClinical Solutions Wholesale2009-07-02Not applicableUs
Bupropion Hydrochloridetablet, film coated, extended release150 mg/1oralRx Change Co.2010-04-08Not applicableUs
Bupropion Hydrochloridetablet, film coated, extended release150 mg/1oralSt Marys Medical Park Pharmacy2014-01-16Not applicableUs
Bupropion Hydrochloridetablet, extended release300 mg/1oralGolden State Medical Supply, Inc.2014-06-24Not applicableUs
Bupropion Hydrochloridetablet, film coated100 mg/1oralAlembic Pharmaceuticals Inc.2015-10-31Not applicableUs
Bupropion Hydrochloridetablet, extended release100 mg/1oralREMEDYREPACK INC.2015-03-26Not applicableUs
Bupropion Hydrochloridetablet, extended release150 mg/1oralMc Kesson Packaging Services A Business Unit Of Mc Kesson Corporation2010-03-31Not applicableUs
Bupropion Hydrochloridetablet, film coated75 mg/1oralbryant ranch prepack2000-02-07Not applicableUs
Bupropion Hydrochloridetablet, film coated, extended release100 mg/1oralMylan Pharmaceuticals Inc.2010-04-09Not applicableUs
Bupropion Hydrochloridetablet, extended release150 mg/1oralActavis South Atlantic LLC2008-03-12Not applicableUs
Bupropion Hydrochloridetablet, extended release150 mg/1oralKAISER FOUNDATION HOSPITALS2009-08-31Not applicableUs
Bupropion Hydrochloridetablet, film coated, extended release100 mg/1oralDispensing Solutions, Inc.2010-04-08Not applicableUs
Bupropion Hydrochloridetablet, film coated, extended release100 mg/1oralNcs Health Care Of Ky, Inc Dba Vangard Labs2010-07-19Not applicableUs
Bupropion Hydrochloridetablet, film coated, extended release300 mg/1oralPd Rx Pharmaceuticals, Inc.2007-06-12Not applicableUs
Bupropion Hydrochloridetablet100 mg/1oralREMEDYREPACK INC.2011-09-12Not applicableUs
Bupropion Hydrochloridetablet, extended release150 mg/1oralSun Pharma Global FZE2014-12-25Not applicableUs
Bupropion Hydrochloridetablet, film coated, extended release100 mg/1oralREMEDYREPACK INC.2013-03-28Not applicableUs
Bupropion Hydrochloridetablet, extended release150 mg/1oralUnit Dose Services2010-03-31Not applicableUs
Bupropion Hydrochloridetablet, film coated, extended release100 mg/1oralSTAT Rx USA LLC2009-07-02Not applicableUs
Bupropion Hydrochloridetablet, film coated75 mg/1oralState of Florida DOH Central Pharmacy2009-07-01Not applicableUs
Bupropion Hydrochloridetablet, film coated75 mg/1oralMajor Pharmaceuticals2010-04-26Not applicableUs
Bupropion Hydrochloridetablet, film coated100 mg/1oralClinical Solutions Wholesale2000-02-07Not applicableUs
Bupropion Hydrochloridetablet, film coated, extended release100 mg/1oralAidarex Pharmaceuticals LLC2010-04-08Not applicableUs
Bupropion Hydrochloridetablet, extended release100 mg/1oralRebel Distributors Corp.2009-09-01Not applicableUs
Bupropion Hydrochloridetablet, film coated100 mg/1oralAmerican Health Packaging2015-10-01Not applicableUs
Bupropion Hydrochloridetablet, extended release150 mg/1oralGolden State Medical Supply, Inc.2014-06-24Not applicableUs
Bupropion Hydrochloridetablet, film coated75 mg/1oralAlembic Pharmaceuticals Inc.2015-10-31Not applicableUs
Bupropion Hydrochloridetablet, film coated100 mg/1oralREMEDYREPACK INC.2014-11-12Not applicableUs
Bupropion Hydrochloridetablet, film coated, extended release300 mg/1oralMylan Pharmaceuticals Inc.2010-09-28Not applicableUs
Bupropion Hydrochloridetablet, film coated75 mg/1oralAphena Pharma Solutions Tennessee, Llc2000-02-07Not applicableUs
Bupropion Hydrochloridetablet, film coated75 mg/1oralKAISER FOUNDATION HOSPITALS2009-09-01Not applicableUs
Bupropion Hydrochloridetablet, film coated75 mg/1oralTYA Pharmaceuticals2000-02-07Not applicableUs
Bupropion Hydrochloridetablet, film coated, extended release150 mg/1oralCardinal Health2010-05-28Not applicableUs
Bupropion Hydrochloridetablet, film coated, extended release100 mg/1oralPreferred Pharmaceuticals, Inc.2013-07-25Not applicableUs
Bupropion Hydrochloridetablet, film coated100 mg/1oralNcs Health Care Of Ky, Inc Dba Vangard Labs2010-02-01Not applicableUs
Bupropion Hydrochloridetablet, film coated, extended release150 mg/1oralPd Rx Pharmaceuticals, Inc.2008-11-25Not applicableUs
Bupropion Hydrochloridetablet, film coated75 mg/1oralREMEDYREPACK INC.2011-05-10Not applicableUs
Bupropion Hydrochloridetablet, film coated, extended release200 mg/1oralSun Pharma Global FZE2015-09-23Not applicableUs
Bupropion Hydrochloridetablet, film coated, extended release150 mg/1oralUnit Dose Services2010-04-08Not applicableUs
Bupropion Hydrochloridetablet, extended release200 mg/1oralTorrent Pharmaceuticals Limited2014-10-31Not applicableUs
Bupropion Hydrochloridetablet, film coated, extended release150 mg/1oralH.J. Harkins Company, Inc.2009-07-02Not applicableUs
Bupropion Hydrochloridetablet, extended release150 mg/1oralSandoz Inc2008-03-12Not applicableUs
Bupropion Hydrochloridetablet, film coated75 mg/1oralClinical Solutions Wholesale2000-02-07Not applicableUs
Bupropion Hydrochloridetablet, film coated, extended release150 mg/1oralAidarex Pharmaceuticals LLC2008-11-25Not applicableUs
Bupropion Hydrochloridetablet, film coated, extended release150 mg/1oralCardinal Health2007-06-12Not applicableUs
Bupropion Hydrochloridetablet, film coated75 mg/1oralAmerican Health Packaging2015-10-01Not applicableUs
Bupropion Hydrochloridetablet, film coated, extended release150 mg/1oralDIRECT RX2015-01-01Not applicableUs
Bupropion Hydrochloridetablet, film coated75 mg/1oralREMEDYREPACK INC.2014-11-06Not applicableUs
Bupropion Hydrochloridetablet, film coated75 mg/1oralbryant ranch prepack2005-04-07Not applicableUs
Bupropion Hydrochloridetablet, film coated, extended release150 mg/1oralMylan Pharmaceuticals Inc.2010-09-28Not applicableUs
Bupropion Hydrochloridetablet, extended release100 mg/1oralAphena Pharma Solutions Tennessee, Llc2003-11-25Not applicableUs
Bupropion Hydrochloridetablet, extended release100 mg/1oralKAISER FOUNDATION HOSPITALS2009-10-01Not applicableUs
Bupropion Hydrochloridetablet, film coated, extended release150 mg/1oralTYA Pharmaceuticals2010-04-08Not applicableUs
Bupropion Hydrochloridetablet, film coated75 mg/1oralBlue Point Laboratories2014-02-07Not applicableUs
Bupropion Hydrochloridetablet, film coated, extended release300 mg/1oralAv Kare, Inc.2016-01-27Not applicableUs
Bupropion Hydrochloridetablet, film coated, extended release300 mg/1oralPreferred Pharmaceuticals, Inc.2014-01-27Not applicableUs
Bupropion Hydrochloride (sr)tablet, film coated, extended release200 mg/1oralWockhardt Limited2012-08-30Not applicableUs
Bupropion Hydrochloride (sr)tablet, film coated, extended release200 mg/1oralWockhardt USA LLC.2012-05-15Not applicableUs
Bupropion Hydrochloride (sr)tablet, film coated, extended release150 mg/1oralWockhardt Limited2012-08-30Not applicableUs
Bupropion Hydrochloride (sr)tablet, film coated, extended release150 mg/1oralWockhardt USA LLC.2012-05-15Not applicableUs
Bupropion Hydrochloride (sr)tablet, film coated, extended release100 mg/1oralWockhardt USA LLC.2012-05-15Not applicableUs
Bupropion Hydrochloride (sr)tablet, film coated, extended release100 mg/1oralWockhardt Limited2012-08-30Not applicableUs
Bupropion Hydrochloride (xl)tablet, film coated, extended release150 mg/1oralWockhardt Limited2012-11-21Not applicableUs
Bupropion Hydrochloride (xl)tablet, film coated, extended release150 mg/1oralWockhardt USA LLC.2012-11-21Not applicableUs
Bupropion Hydrochloride ERtablet150 mg/1oralNorthwind Pharmaceuticals2014-06-01Not applicableUs
Bupropion Hydrochloride Extended Release (xl)tablet, extended release150 mg/1oralPhysicians Total Care, Inc.2008-08-13Not applicableUs
Bupropion Hydrochloride Extended Release (xl)tablet, extended release300 mg/1oralPhysicians Total Care, Inc.2009-07-23Not applicableUs
Bupropion Hydrochloride Extended Release SRtablet, film coated, extended release150 mg/1oralLake Erie Medical DBA Quality Care Products LLC2010-10-04Not applicableUs
Bupropion Hydrochloride SRtablet, film coated, extended release150 mg/1oralActavis Pharma, Inc.2009-07-02Not applicableUs
Bupropion Hydrochloride SRtablet, film coated, extended release100 mg/1oralGolden State Medical Supply, Inc.2014-06-24Not applicableUs
Bupropion Hydrochloride SRtablet, film coated, extended release150 mg/1oralGolden State Medical Supply, Inc.2014-06-24Not applicableUs
Bupropion Hydrochloride SRtablet, film coated, extended release100 mg/1oralActavis Pharma, Inc.2009-07-02Not applicableUs
Bupropion Hydrochloride SRtablet, film coated, extended release200 mg/1oralScie Gen Pharmaceuticals, Inc.2016-02-10Not applicableUs
Bupropion Hydrochloride SRtablet, extended release150 mg/1oralNcs Health Care Of Ky, Inc Dba Vangard Labs2004-03-22Not applicableUs
Bupropion Hydrochloride SRtablet, film coated, extended release150 mg/1oralScie Gen Pharmaceuticals, Inc.2016-02-10Not applicableUs
Bupropion Hydrochloride SRtablet, extended release200 mg/1oralPhysicians Total Care, Inc.2011-09-08Not applicableUs
Bupropion Hydrochloride SRtablet, film coated, extended release100 mg/1oralScie Gen Pharmaceuticals, Inc.2016-02-10Not applicableUs
Bupropion Hydrochloride SRtablet, film coated, extended release150 mg/1oralActavis Pharma, Inc.2009-08-25Not applicableUs
Bupropion Hydrochloride SRtablet, extended release100 mg/1oralPhysicians Total Care, Inc.2007-04-10Not applicableUs
Bupropion Hydrochloride SRtablet, film coated, extended release200 mg/1oralProficient Rx LP2009-07-02Not applicableUs
Bupropion Hydrochloride SRtablet, film coated, extended release200 mg/1oralActavis Pharma, Inc.2009-07-02Not applicableUs
Bupropion Hydrochloride SRtablet, extended release150 mg/1oralPhysicians Total Care, Inc.2004-03-22Not applicableUs
Bupropion Hydrochloride SRtablet, film coated, extended release200 mg/1oralGolden State Medical Supply, Inc.2014-06-24Not applicableUs
Bupropion Hydrochloride SR (sr)tablet, film coated, extended release150 mg/1oralAidarex Pharmaceuticals LLC2012-05-15Not applicableUs
Bupropion Hydrochloride XLtablet, film coated, extended release300 mg/1oralbryant ranch prepack2008-11-26Not applicableUs
Bupropion Hydrochloride XLtablet, film coated, extended release150 mg/1oralActavis Pharma, Inc.2008-11-26Not applicableUs
Bupropion Hydrochloride XLtablet, film coated, extended release150 mg/1oralLake Erie Medical DBA Quality Care Products LLC2008-11-26Not applicableUs
Bupropion Hydrochloride XLtablet, film coated, extended release300 mg/1oralLake Erie Medical DBA Quality Care Products LLC2010-07-14Not applicableUs
Bupropion Hydrochloride XLtablet, film coated, extended release150 mg/1oralSt Marys Medical Park Pharmacy2014-05-22Not applicableUs
Bupropion Hydrochloride XLtablet, film coated, extended release300 mg/1oralRebel Distributors Corp2007-06-13Not applicableUs
Bupropion Hydrochloride XLtablet, film coated, extended release150 mg/1oralDispensing Solutions, Inc.2008-11-26Not applicableUs
Bupropion Hydrochloride XLtablet, film coated, extended release150 mg/1oralBlue Point Laboratories2014-02-24Not applicableUs
Bupropion Hydrochloride XLtablet, film coated, extended release150 mg/1oralRebel Distributors Corp2008-11-26Not applicableUs
Bupropion Hydrochloride XLtablet, film coated, extended release300 mg/1oralDispensing Solutions, Inc.2007-06-13Not applicableUs
Bupropion Hydrochloride4b17detablet, film coated, extended release150 mg/1oralPd Rx Pharmaceuticals, Inc.2010-04-08Not applicableUs
Bupropion Hydrochloridexl XLtablet, film coated, extended release300 mg/1oralREMEDYREPACK INC.2013-06-03Not applicableUs
Bupropion Hydrocloridetablet, film coated75 mg/1oralREMEDYREPACK INC.2011-03-14Not applicableUs
Approved Over the Counter ProductsNot Available
Unapproved/Other Products Not Available
International Brands
NameCompany
ElontrilNot Available
ForfivoNot Available
PrexatonNot Available
VoxraNot Available
Brand mixtures
NameLabellerIngredients
AppbutamonePhysician Therapeutics Llc
Appbutamone-DPhysician Therapeutics Llc
ContraveTakeda Pharmaceuticals America, Inc.
Salts
Name/CASStructureProperties
Bupropion hydrobromide
905818-69-1
ThumbNot applicableDBSALT001210
Bupropion hydrochloride
31677-93-7
Thumb
  • InChI Key: HEYVINCGKDONRU-UHFFFAOYNA-N
  • Monoisotopic Mass: 275.084369649
  • Average Mass: 276.202
DBSALT000199
Categories
UNII01ZG3TPX31
CAS number34911-55-2
WeightAverage: 239.741
Monoisotopic: 239.10769191
Chemical FormulaC13H18ClNO
InChI KeyInChIKey=SNPPWIUOZRMYNY-UHFFFAOYSA-N
InChI
InChI=1S/C13H18ClNO/c1-9(15-13(2,3)4)12(16)10-6-5-7-11(14)8-10/h5-9,15H,1-4H3
IUPAC Name
2-(tert-butylamino)-1-(3-chlorophenyl)propan-1-one
SMILES
CC(NC(C)(C)C)C(=O)C1=CC(Cl)=CC=C1
Taxonomy
DescriptionThis compound belongs to the class of organic compounds known as acetophenones. These are organic compounds containing the acetophenone structure.
KingdomOrganic compounds
Super ClassBenzenoids
ClassBenzene and substituted derivatives
Sub ClassAcetophenones
Direct ParentAcetophenones
Alternative Parents
Substituents
  • Phenylpropane
  • Acetophenone
  • Aryl alkyl ketone
  • Aryl ketone
  • Benzoyl
  • Halobenzene
  • Chlorobenzene
  • Aryl halide
  • Aryl chloride
  • Alpha-aminoketone
  • Ketone
  • Secondary amine
  • Secondary aliphatic amine
  • Hydrocarbon derivative
  • Organooxygen compound
  • Organonitrogen compound
  • Organochloride
  • Organohalogen compound
  • Carbonyl group
  • Amine
  • Aromatic homomonocyclic compound
Molecular FrameworkAromatic homomonocyclic compounds
External DescriptorsNot Available
Pharmacology
IndicationFor the treatment of depression and as aid to smoking cessation.
PharmacodynamicsBupropion, an antidepressant of the aminoketone class and a non-nicotine aid to smoking cessation, is chemically unrelated to tricyclic, tetracyclic, selective serotonin re-uptake inhibitor, or other known antidepressant agents. Compared to classical tricyclic antidepressants, Bupropion is a relatively weak inhibitor of the neuronal uptake of norepinephrine, serotonin, and dopamine. In addition, Bupropion does not inhibit monoamine oxidase. Bupropion produces dose-related central nervous system (CNS) stimulant effects in animals, as evidenced by increased locomotor activity, increased rates of responding in various schedule-controlled operant behavior tasks, and, at high doses, induction of mild stereotyped behavior.
Mechanism of actionBupropion selectively inhibits the neuronal reuptake of dopamine, norepinephrine, and serotonin; actions on dopaminergic systems are more significant than imipramine or amitriptyline whereas the blockade of norepinephrine and serotonin reuptake at the neuronal membrane is weaker for bupropion than for tricyclic antidepressants. The increase in norepinephrine may attenuate nicotine withdrawal symptoms and the increase in dopamine at neuronal sites may reduce nicotine cravings and the urge to smoke. Bupropion exhibits moderate anticholinergic effects.
Related Articles
AbsorptionFor sustained release, peak plasma concentrations are achieved within 3 hours.
Volume of distributionNot Available
Protein binding84 %
Metabolism

Reduction of the carbonyl groupand/or hydroxylation of the tert-butyl group of bupropion.

SubstrateEnzymesProduct
Bupropion
HydroxybupropionDetails
Route of eliminationBupropion is extensively metabolized in humans. Oxidation of the bupropion side chain results in the formation of a glycine conjugate of metachlorobenzoic acid, which is then excreted as the major urinary metabolite. Following oral administration of 200 mg of 14C-bupropion in humans, 87% and 10% of the radioactive dose were recovered in the urine and feces, respectively. However, the fraction of the oral dose of bupropion excreted unchanged was only 0.5%, a finding consistent with the extensive metabolism of bupropion.
Half life24 hours
ClearanceNot Available
ToxicitySymptoms of overdose include seizures, hallucinations, loss of consciousness, tachycardia, and cardiac arrest.
Affected organisms
  • Humans and other mammals
PathwaysNot Available
SNP Mediated Effects
Interacting Gene/EnzymeSNP RS IDAllele nameDefining changeEffectReference(s)
D(2) dopamine receptor
Gene symbol: DRD2
UniProt: P14416
rs1800491 Not AvailableC AlleleImproved response in smoking cessation18058343
SNP Mediated Adverse Drug ReactionsNot Available
ADMET
Predicted ADMET features
PropertyValueProbability
Human Intestinal Absorption+1.0
Blood Brain Barrier+0.975
Caco-2 permeable+0.8866
P-glycoprotein substrateNon-substrate0.733
P-glycoprotein inhibitor INon-inhibitor0.8738
P-glycoprotein inhibitor IINon-inhibitor0.9343
Renal organic cation transporterNon-inhibitor0.8814
CYP450 2C9 substrateNon-substrate0.785
CYP450 2D6 substrateNon-substrate0.9116
CYP450 3A4 substrateSubstrate0.574
CYP450 1A2 substrateNon-inhibitor0.7499
CYP450 2C9 inhibitorNon-inhibitor0.907
CYP450 2D6 inhibitorInhibitor0.8932
CYP450 2C19 inhibitorInhibitor0.8993
CYP450 3A4 inhibitorNon-inhibitor0.7743
CYP450 inhibitory promiscuityHigh CYP Inhibitory Promiscuity0.5141
Ames testNon AMES toxic0.9233
CarcinogenicityNon-carcinogens0.5609
BiodegradationNot ready biodegradable0.9892
Rat acute toxicity2.4363 LD50, mol/kg Not applicable
hERG inhibition (predictor I)Weak inhibitor0.9684
hERG inhibition (predictor II)Non-inhibitor0.8886
ADMET data is predicted using admetSAR, a free tool for evaluating chemical ADMET properties. (23092397 )
Pharmacoeconomics
ManufacturersNot Available
Packagers
Dosage forms
FormRouteStrength
Tablet, extended releaseoral174 mg/1
Tablet, extended releaseoral348 mg/1
Tablet, extended releaseoral522 mg/1
Kit
Tablet, extended releaseoral150 mg/1
Tabletocclusive dressing technique150 mg/1
Tabletoral100 mg/1
Tabletoral75 mg/1
Tablet, extended releaseoral100 mg/1
Tablet, extended releaseoral200 mg/1
Tablet, film coatedocclusive dressing technique75 mg/1
Tablet, film coated, extended releaseocclusive dressing technique150 mg/1
Tablet, film coated, extended releaseoral100 mg/1
Tablet, film coated, extended releaseoral150 mg/1
Tablet, film coated, extended releaseoral200 mg/1
Tablet, film coated, extended releaseoral300 mg/1
Tabletoral150 mg/1
Tablet, film coated, extended releaseoral
Tablet, film coated, extended releaseoral450 mg/1
Tablet (extended-release)oral100 mg
Tablet, film coatedoral100 mg/1
Tablet, film coatedoral75 mg/1
Tablet (extended-release)oral150 mg
Tablet, film coatedoral150 mg/1
Tablet, film coatedoral200 mg/1
Tablet (extended-release)oral300 mg
Tablet, extended releaseoral300 mg/1
Prices
Unit descriptionCostUnit
Aplenzin er 522 mg tablet16.74USD tablet
Bupropion hydrochloride powder10.2USD g
Wellbutrin XL 300 mg 24 Hour tablet9.03USD tablet
Wellbutrin xl 300 mg tablet8.68USD tablet
Wellbutrin SR 200 mg 12 Hour tablet7.57USD tablet
Aplenzin er 348 mg tablet7.36USD tablet
Wellbutrin sr 200 mg tablet7.27USD tablet
Wellbutrin XL 150 mg 24 Hour tablet6.84USD tablet
Wellbutrin xl 150 mg tablet6.58USD tablet
Aplenzin er 174 mg tablet5.58USD tablet
BuPROPion HCl 300 mg 24 Hour tablet4.96USD tablet
Wellbutrin SR 150 mg 12 Hour tablet4.07USD tablet
BuPROPion HCl 200 mg 12 Hour tablet3.99USD tablet
Wellbutrin sr 150 mg tablet3.92USD tablet
Zyban 150 mg 12 Hour tablet3.88USD tablet
Wellbutrin SR 100 mg 12 Hour tablet3.8USD tablet
Zyban sr 150 mg tablet3.73USD tablet
Wellbutrin sr 100 mg tablet3.66USD tablet
Wellbutrin 100 mg tablet3.62USD tablet
BuPROPion HCl 150 mg 12 Hour tablet3.02USD tablet
Wellbutrin 75 mg tablet2.71USD tablet
BuPROPion HCl (Smoking Deter) 150 mg 12 Hour tablet2.01USD tablet
Wellbutrin Xl 300 mg Extended-Release Tablet1.12USD tablet
Bupropion hcl 100 mg tablet0.98USD tablet
Wellbutrin Sr 150 mg Sustained-Release Tablet0.96USD tablet
Bupropion hcl 75 mg tablet0.74USD tablet
Wellbutrin Xl 150 mg Extended-Release Tablet0.56USD tablet
Pms-Bupropion Sr 150 mg Sustained-Release Tablet0.53USD tablet
Ratio-Bupropion Sr 150 mg Sustained-Release Tablet0.53USD tablet
Sandoz Bupropion Sr 150 mg Sustained-Release Tablet0.53USD tablet
Sandoz Bupropion Sr 100 mg Sustained-Release Tablet0.35USD tablet
Ratio-Bupropion Sr 100 mg Sustained-Release Tablet0.35USD tablet
DrugBank does not sell nor buy drugs. Pricing information is supplied for informational purposes only.
Patents
Patent NumberPediatric ExtensionApprovedExpires (estimated)
CA2168364 No2001-09-182014-07-29Canada
CA2524300 No2008-10-282023-08-08Canada
US5358970 No1993-08-122013-08-12Us
US6096341 No1998-10-302018-10-30Us
US7241805 No2006-06-272026-06-27Us
US7375111 No2005-03-262025-03-26Us
US7462626 No2004-07-202024-07-20Us
US7569610 No2006-06-272026-06-27Us
US7572935 No2006-06-272026-06-27Us
US7585897 No2006-06-272026-06-27Us
US7645802 No2006-06-272026-06-27Us
US7649019 No2006-06-272026-06-27Us
US7662407 No2006-06-272026-06-27Us
US7671094 No2006-06-272026-06-27Us
US7674479 No2007-06-252027-06-25Us
US8088786 No2009-02-032029-02-03Us
US8318788 No2007-11-082027-11-08Us
US8722085 No2007-11-082027-11-08Us
US8815889 No2004-07-202024-07-20Us
US8916195 No2010-02-022030-02-02Us
US9107837 No2007-06-042027-06-04Us
US9125868 No2007-11-082027-11-08Us
US9248123 No2012-01-132032-01-13Us
Properties
StateSolid
Experimental Properties
PropertyValueSource
melting point233-234 °CNot Available
water solubility312 mg/mlNot Available
logP3.6Not Available
Predicted Properties
PropertyValueSource
Water Solubility0.0693 mg/mLALOGPS
logP3.28ALOGPS
logP3.27ChemAxon
logS-3.5ALOGPS
pKa (Strongest Acidic)18.29ChemAxon
pKa (Strongest Basic)8.22ChemAxon
Physiological Charge1ChemAxon
Hydrogen Acceptor Count2ChemAxon
Hydrogen Donor Count1ChemAxon
Polar Surface Area29.1 Å2ChemAxon
Rotatable Bond Count4ChemAxon
Refractivity67.7 m3·mol-1ChemAxon
Polarizability25.93 Å3ChemAxon
Number of Rings1ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleYesChemAxon
Spectra
Mass Spec (NIST)Not Available
SpectraNot Available
References
Synthesis Reference

DrugSyn.org

US3819706
General References
  1. Fryer JD, Lukas RJ: Noncompetitive functional inhibition at diverse, human nicotinic acetylcholine receptor subtypes by bupropion, phencyclidine, and ibogaine. J Pharmacol Exp Ther. 1999 Jan;288(1):88-92. [PubMed:9862757 ]
  2. Fava M, Rush AJ, Thase ME, Clayton A, Stahl SM, Pradko JF, Johnston JA: 15 years of clinical experience with bupropion HCl: from bupropion to bupropion SR to bupropion XL. Prim Care Companion J Clin Psychiatry. 2005;7(3):106-13. [PubMed:16027765 ]
  3. Thase ME, Haight BR, Richard N, Rockett CB, Mitton M, Modell JG, VanMeter S, Harriett AE, Wang Y: Remission rates following antidepressant therapy with bupropion or selective serotonin reuptake inhibitors: a meta-analysis of original data from 7 randomized controlled trials. J Clin Psychiatry. 2005 Aug;66(8):974-81. [PubMed:16086611 ]
  4. Authors unspecified: Annual report on the results of treatment in gynecological cancer. Twenty-first volume. Statements of results obtained in patients treated in 1982 to 1986, inclusive 3 and 5-year survival up to 1990. Int J Gynaecol Obstet. 1991 Sep;36 Suppl:1-315. [PubMed:1684162 ]
  5. Thase ME, Clayton AH, Haight BR, Thompson AH, Modell JG, Johnston JA: A double-blind comparison between bupropion XL and venlafaxine XR: sexual functioning, antidepressant efficacy, and tolerability. J Clin Psychopharmacol. 2006 Oct;26(5):482-8. [PubMed:16974189 ]
External Links
ATC CodesA08AA62N06AX12
AHFS Codes
  • 28:16.04.92
PDB EntriesNot Available
FDA labelDownload (88.6 KB)
MSDSNot Available
Interactions
Drug Interactions
Drug
AmantadineThe risk or severity of adverse effects can be increased when Amantadine is combined with Bupropion.
AmilorideThe serum concentration of Amiloride can be increased when it is combined with Bupropion.
AmitriptylineThe metabolism of Amitriptyline can be decreased when combined with Bupropion.
ApomorphineThe risk or severity of adverse effects can be increased when Apomorphine is combined with Bupropion.
AripiprazoleThe serum concentration of Aripiprazole can be increased when it is combined with Bupropion.
AtomoxetineThe serum concentration of Atomoxetine can be increased when it is combined with Bupropion.
BrexpiprazoleThe serum concentration of Brexpiprazole can be increased when it is combined with Bupropion.
BromocriptineThe risk or severity of adverse effects can be increased when Bromocriptine is combined with Bupropion.
CholineThe serum concentration of Choline can be increased when it is combined with Bupropion.
CimetidineThe serum concentration of Cimetidine can be increased when it is combined with Bupropion.
CitalopramThe risk or severity of adverse effects can be increased when Bupropion is combined with Citalopram.
ClomipramineThe metabolism of Clomipramine can be decreased when combined with Bupropion.
ClopidogrelThe serum concentration of Bupropion can be increased when it is combined with Clopidogrel.
CodeineThe therapeutic efficacy of Codeine can be decreased when used in combination with Bupropion.
CrizotinibThe serum concentration of Bupropion can be increased when it is combined with Crizotinib.
DabrafenibThe serum concentration of Bupropion can be decreased when it is combined with Dabrafenib.
DesipramineThe metabolism of Desipramine can be decreased when combined with Bupropion.
DopamineThe serum concentration of Dopamine can be increased when it is combined with Bupropion.
DoxepinThe metabolism of Doxepin can be decreased when combined with Bupropion.
DoxorubicinThe serum concentration of Doxorubicin can be increased when it is combined with Bupropion.
DuloxetineThe serum concentration of Duloxetine can be increased when it is combined with Bupropion.
EfavirenzThe serum concentration of Bupropion can be decreased when it is combined with Efavirenz.
EliglustatThe serum concentration of Eliglustat can be increased when it is combined with Bupropion.
EthanolThe risk or severity of adverse effects can be increased when Ethanol is combined with Bupropion.
FamotidineThe serum concentration of Famotidine can be increased when it is combined with Bupropion.
FesoterodineThe serum concentration of the active metabolites of Fesoterodine can be increased when Fesoterodine is used in combination with Bupropion.
FluoxetineThe risk or severity of adverse effects can be increased when Bupropion is combined with Fluoxetine.
FluvoxamineThe risk or severity of adverse effects can be increased when Bupropion is combined with Fluvoxamine.
HydrocodoneThe serum concentration of the active metabolites of Hydrocodone can be reduced when Hydrocodone is used in combination with Bupropion resulting in a loss in efficacy.
IloperidoneThe serum concentration of the active metabolites of Iloperidone can be increased when Iloperidone is used in combination with Bupropion.
ImipramineThe metabolism of Imipramine can be decreased when combined with Bupropion.
Ioflupane I 123Bupropion may decrease effectiveness of Ioflupane I 123 as a diagnostic agent.
IsavuconazoniumThe serum concentration of Bupropion can be decreased when it is combined with Isavuconazonium.
IsocarboxazidIsocarboxazid may increase the hypertensive activities of Bupropion.
LinezolidLinezolid may increase the hypertensive activities of Bupropion.
LopinavirThe serum concentration of Bupropion can be decreased when it is combined with Lopinavir.
LorcaserinBupropion may increase the serotonergic activities of Lorcaserin.
LumacaftorThe serum concentration of Bupropion can be decreased when it is combined with Lumacaftor.
MemantineThe serum concentration of Memantine can be increased when it is combined with Bupropion.
MequitazineThe serum concentration of Mequitazine can be increased when it is combined with Bupropion.
MetforminThe serum concentration of Metformin can be increased when it is combined with Bupropion.
MetoprololThe serum concentration of Metoprolol can be increased when it is combined with Bupropion.
MifepristoneThe serum concentration of Bupropion can be increased when it is combined with Mifepristone.
MoclobemideMoclobemide may increase the hypertensive activities of Bupropion.
NebivololThe serum concentration of Nebivolol can be increased when it is combined with Bupropion.
NevirapineThe metabolism of Bupropion can be increased when combined with Nevirapine.
NortriptylineThe metabolism of Nortriptyline can be decreased when combined with Bupropion.
OxaliplatinThe serum concentration of Oxaliplatin can be increased when it is combined with Bupropion.
ParoxetineThe risk or severity of adverse effects can be increased when Bupropion is combined with Paroxetine.
PhenelzinePhenelzine may increase the hypertensive activities of Bupropion.
PimozideThe serum concentration of Pimozide can be increased when it is combined with Bupropion.
PindololThe serum concentration of Pindolol can be increased when it is combined with Bupropion.
PramipexoleThe risk or severity of adverse effects can be increased when Pramipexole is combined with Bupropion.
ProcarbazineProcarbazine may increase the hypertensive activities of Bupropion.
PropafenoneThe serum concentration of Propafenone can be increased when it is combined with Bupropion.
QuazepamThe serum concentration of Bupropion can be increased when it is combined with Quazepam.
RanitidineThe serum concentration of Ranitidine can be increased when it is combined with Bupropion.
RasagilineRasagiline may increase the hypertensive activities of Bupropion.
RitonavirThe serum concentration of Bupropion can be decreased when it is combined with Ritonavir.
RopiniroleThe risk or severity of adverse effects can be increased when Ropinirole is combined with Bupropion.
RotigotineThe risk or severity of adverse effects can be increased when Rotigotine is combined with Bupropion.
SelegilineSelegiline may increase the hypertensive activities of Bupropion.
SorafenibThe serum concentration of Bupropion can be increased when it is combined with Sorafenib.
TamoxifenThe serum concentration of the active metabolites of Tamoxifen can be reduced when Tamoxifen is used in combination with Bupropion resulting in a loss in efficacy.
TamsulosinThe serum concentration of Tamsulosin can be increased when it is combined with Bupropion.
Tedizolid PhosphateTedizolid Phosphate may increase the hypertensive activities of Bupropion.
TetrabenazineThe serum concentration of Tetrabenazine can be increased when it is combined with Bupropion.
ThioridazineThe serum concentration of Thioridazine can be increased when it is combined with Bupropion.
ThiotepaThe serum concentration of Bupropion can be increased when it is combined with Thiotepa.
TiclopidineThe serum concentration of Bupropion can be increased when it is combined with Ticlopidine.
TramadolThe therapeutic efficacy of Tramadol can be decreased when used in combination with Bupropion.
TranylcypromineTranylcypromine may increase the hypertensive activities of Bupropion.
TrimipramineThe metabolism of Trimipramine can be decreased when combined with Bupropion.
VareniclineThe serum concentration of Varenicline can be increased when it is combined with Bupropion.
VortioxetineThe risk or severity of adverse effects can be increased when Bupropion is combined with Vortioxetine.
Food Interactions
  • Avoid alcohol.
  • Avoid St.John's Wort.
  • Take without regard to meals.

Targets

Kind
Protein
Organism
Human
Pharmacological action
yes
Actions
inhibitor
General Function:
Monoamine transmembrane transporter activity
Specific Function:
Amine transporter. Terminates the action of dopamine by its high affinity sodium-dependent reuptake into presynaptic terminals.
Gene Name:
SLC6A3
Uniprot ID:
Q01959
Molecular Weight:
68494.255 Da
References
  1. Miller DK, Sumithran SP, Dwoskin LP: Bupropion inhibits nicotine-evoked [(3)H]overflow from rat striatal slices preloaded with [(3)H]dopamine and from rat hippocampal slices preloaded with [(3)H]norepinephrine. J Pharmacol Exp Ther. 2002 Sep;302(3):1113-22. [PubMed:12183670 ]
  2. Meyer JH, Goulding VS, Wilson AA, Hussey D, Christensen BK, Houle S: Bupropion occupancy of the dopamine transporter is low during clinical treatment. Psychopharmacology (Berl). 2002 Aug;163(1):102-5. Epub 2002 Jul 13. [PubMed:12185406 ]
  3. Kugaya A, Seneca NM, Snyder PJ, Williams SA, Malison RT, Baldwin RM, Seibyl JP, Innis RB: Changes in human in vivo serotonin and dopamine transporter availabilities during chronic antidepressant administration. Neuropsychopharmacology. 2003 Feb;28(2):413-20. Epub 2002 Jul 19. [PubMed:12589396 ]
  4. Learned-Coughlin SM, Bergstrom M, Savitcheva I, Ascher J, Schmith VD, Langstrom B: In vivo activity of bupropion at the human dopamine transporter as measured by positron emission tomography. Biol Psychiatry. 2003 Oct 15;54(8):800-5. [PubMed:14550679 ]
  5. Szabo Z, Argyelan M, Kanyo B, Pavics L, Janka Z: [Change of dopamine transporter activity (DAT) during the action of bupropion (in depression)]. Neuropsychopharmacol Hung. 2004 Jun;6(2):79-81. [PubMed:15787205 ]
  6. Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. [PubMed:11752352 ]
  7. Tatsumi M, Groshan K, Blakely RD, Richelson E: Pharmacological profile of antidepressants and related compounds at human monoamine transporters. Eur J Pharmacol. 1997 Dec 11;340(2-3):249-58. [PubMed:9537821 ]
  8. Stahl SM, Pradko JF, Haight BR, Modell JG, Rockett CB, Learned-Coughlin S: A Review of the Neuropharmacology of Bupropion, a Dual Norepinephrine and Dopamine Reuptake Inhibitor. Prim Care Companion J Clin Psychiatry. 2004;6(4):159-166. [PubMed:15361919 ]
Kind
Protein
Organism
Human
Pharmacological action
yes
Actions
inhibitor
General Function:
Norepinephrine:sodium symporter activity
Specific Function:
Amine transporter. Terminates the action of noradrenaline by its high affinity sodium-dependent reuptake into presynaptic terminals.
Gene Name:
SLC6A2
Uniprot ID:
P23975
Molecular Weight:
69331.42 Da
References
  1. Bondarev ML, Bondareva TS, Young R, Glennon RA: Behavioral and biochemical investigations of bupropion metabolites. Eur J Pharmacol. 2003 Aug 1;474(1):85-93. [PubMed:12909199 ]
  2. Mitchell HA, Ahern TH, Liles LC, Javors MA, Weinshenker D: The effects of norepinephrine transporter inactivation on locomotor activity in mice. Biol Psychiatry. 2006 Nov 15;60(10):1046-52. Epub 2006 Aug 7. [PubMed:16893531 ]
  3. Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. [PubMed:11752352 ]
  4. Stahl SM, Pradko JF, Haight BR, Modell JG, Rockett CB, Learned-Coughlin S: A Review of the Neuropharmacology of Bupropion, a Dual Norepinephrine and Dopamine Reuptake Inhibitor. Prim Care Companion J Clin Psychiatry. 2004;6(4):159-166. [PubMed:15361919 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
antagonist
General Function:
Ligand-gated ion channel activity
Specific Function:
After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.
Gene Name:
CHRNA3
Uniprot ID:
P32297
Molecular Weight:
57479.54 Da
References
  1. Fryer JD, Lukas RJ: Noncompetitive functional inhibition at diverse, human nicotinic acetylcholine receptor subtypes by bupropion, phencyclidine, and ibogaine. J Pharmacol Exp Ther. 1999 Jan;288(1):88-92. [PubMed:9862757 ]
  2. Slemmer JE, Martin BR, Damaj MI: Bupropion is a nicotinic antagonist. J Pharmacol Exp Ther. 2000 Oct;295(1):321-7. [PubMed:10991997 ]

Enzymes

Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrateinhibitor
General Function:
Steroid hydroxylase activity
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. Acts as a 1,4-cineole 2-exo-monooxygenase.
Gene Name:
CYP2B6
Uniprot ID:
P20813
Molecular Weight:
56277.81 Da
References
  1. Walsky RL, Astuccio AV, Obach RS: Evaluation of 227 drugs for in vitro inhibition of cytochrome P450 2B6. J Clin Pharmacol. 2006 Dec;46(12):1426-38. [PubMed:17101742 ]
  2. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
  3. Lewis DF, Modi S, Dickins M: Structure-activity relationship for human cytochrome P450 substrates and inhibitors. Drug Metab Rev. 2002 Feb-May;34(1-2):69-82. [PubMed:11996013 ]
  4. Hesse LM, Venkatakrishnan K, Court MH, von Moltke LL, Duan SX, Shader RI, Greenblatt DJ: CYP2B6 mediates the in vitro hydroxylation of bupropion: potential drug interactions with other antidepressants. Drug Metab Dispos. 2000 Oct;28(10):1176-83. [PubMed:10997936 ]
  5. Jefferson JW, Pradko JF, Muir KT: Bupropion for major depressive disorder: Pharmacokinetic and formulation considerations. Clin Ther. 2005 Nov;27(11):1685-95. [PubMed:16368442 ]
  6. Foley KF, DeSanty KP, Kast RE: Bupropion: pharmacology and therapeutic applications. Expert Rev Neurother. 2006 Sep;6(9):1249-65. [PubMed:17009913 ]
  7. Drug Interactions: Cytochrome P450 Drug Interaction Table [Link]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrateinhibitor
General Function:
Steroid hydroxylase activity
Specific Function:
Responsible for the metabolism of many drugs and environmental chemicals that it oxidizes. It is involved in the metabolism of drugs such as antiarrhythmics, adrenoceptor antagonists, and tricyclic antidepressants.
Gene Name:
CYP2D6
Uniprot ID:
P10635
Molecular Weight:
55768.94 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
  2. Foley KF, DeSanty KP, Kast RE: Bupropion: pharmacology and therapeutic applications. Expert Rev Neurother. 2006 Sep;6(9):1249-65. [PubMed:17009913 ]
  3. Drug Interactions: Cytochrome P450 Drug Interaction Table [Link]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrate
General Function:
Oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. Most active in catalyzing 2-hydroxylation. Caffeine is metabolized primarily by cytochrome CYP1A2 in the liver through an initial N...
Gene Name:
CYP1A2
Uniprot ID:
P05177
Molecular Weight:
58293.76 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrate
General Function:
Steroid hydroxylase activity
Specific Function:
Exhibits a high coumarin 7-hydroxylase activity. Can act in the hydroxylation of the anti-cancer drugs cyclophosphamide and ifosphamide. Competent in the metabolic activation of aflatoxin B1. Constitutes the major nicotine C-oxidase. Acts as a 1,4-cineole 2-exo-monooxygenase. Possesses low phenacetin O-deethylation activity.
Gene Name:
CYP2A6
Uniprot ID:
P11509
Molecular Weight:
56501.005 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrate
General Function:
Steroid hydroxylase activity
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. In the epoxidation of arachidonic acid it generates only 14,15- and 11,12-cis-epoxyeicosatrienoic acids. It is the principal enzyme...
Gene Name:
CYP2C8
Uniprot ID:
P10632
Molecular Weight:
55824.275 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrate
General Function:
Steroid hydroxylase activity
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. This enzyme contributes to the wide pharmacokinetics variability of the metabolism of drugs such as S-warfarin, diclofenac, phenyto...
Gene Name:
CYP2C9
Uniprot ID:
P11712
Molecular Weight:
55627.365 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrate
General Function:
Steroid hydroxylase activity
Specific Function:
Metabolizes several precarcinogens, drugs, and solvents to reactive metabolites. Inactivates a number of drugs and xenobiotics and also bioactivates many xenobiotic substrates to their hepatotoxic or carcinogenic forms.
Gene Name:
CYP2E1
Uniprot ID:
P05181
Molecular Weight:
56848.42 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrate
General Function:
Vitamin d3 25-hydroxylase activity
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It performs a variety of oxidation reactions (e.g. caffeine 8-oxidation, omeprazole sulphoxidation, midazolam 1'-hydroxylation and midazolam 4-hydroxylation) of structurally unrelated compounds, including steroids, fatty acids, and xenobiot...
Gene Name:
CYP3A4
Uniprot ID:
P08684
Molecular Weight:
57342.67 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]

Carriers

Kind
Protein
Organism
Human
Pharmacological action
no
General Function:
Not Available
Specific Function:
Functions as transport protein in the blood stream. Binds various ligands in the interior of its beta-barrel domain. Also binds synthetic drugs and influences their distribution and availability in the body. Appears to function in modulating the activity of the immune system during the acute-phase reaction.
Gene Name:
ORM1
Uniprot ID:
P02763
Molecular Weight:
23511.38 Da
References
  1. Ferry DG, Caplan NB, Cubeddu LX: Interaction between antidepressants and alpha 1-adrenergic receptor antagonists on the binding to alpha 1-acid glycoprotein. J Pharm Sci. 1986 Feb;75(2):146-9. [PubMed:2870173 ]
Comments
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Drug created on June 13, 2005 07:24 / Updated on May 27, 2016 02:25