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Identification
NameHydralazine
Accession NumberDB01275
TypeSmall Molecule
GroupsApproved
Description

A direct-acting vasodilator that is used as an antihypertensive agent. [PubChem]

Structure
Thumb
Synonyms
(1Z)-1(2H)-Phthalazinone hydrazone
(2H)-Phthalazinone hydrazone
1-Hydrazinophthalazine
1-Phthalazinylhydrazine
6-Hydralazine
Hidralazina
Hydralazin
Hydralazinum
Hydrallazine
Hydrazinophthalazine
Hydrazone 1(2H)-phthalazinone
Hypophthalin
Idralazina
Phthalazin-1-ylhydrazine
External Identifiers Not Available
Approved Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Apresolinesolution20 mgintravenousSterimax Inc1992-12-31Not applicableCanada
Apresoline Tablets, 10mgtablet10 mgoralSterimax Inc1952-12-312005-07-22Canada
Apresoline Tablets, 25mgtablet25 mgoralSterimax Inc1952-12-312005-07-19Canada
Apresoline Tablets, 50mgtablet50 mgoralSterimax Inc1952-12-312005-07-19Canada
Hydralazinetablet10 mgoralAa Pharma Inc1990-12-31Not applicableCanada
Hydralazinetablet50 mgoralAa Pharma Inc1991-12-31Not applicableCanada
Hydralazinetablet25 mgoralAa Pharma Inc1991-12-31Not applicableCanada
Hydralazine Hydrochloride Injectionsolution20 mgintravenousFresenius Kabi Canada LtdNot applicableNot applicableCanada
Hydralazine-10 Tab 10mgtablet10 mgoralPro Doc Limitee1991-12-312010-07-13Canada
Hydralazine-25 Tabtablet25 mgoralPro Doc Limitee1994-12-312010-07-13Canada
Hydralazine-50 Tabtablet50 mgoralPro Doc Limitee1994-12-312010-07-13Canada
Novo-hylazin Tab 10mg USPtablet10 mgoralNovopharm Limited1992-12-312012-05-08Canada
Novo-hylazin Tab 25mgtablet25 mgoralNovopharm Limited1987-12-312012-05-09Canada
Novo-hylazin Tab 50mgtablet50 mgoralNovopharm Limited1987-12-312012-05-09Canada
Nu-hydral Tab 10mgtablet10 mgoralNu Pharm Inc1992-12-312012-09-04Canada
Nu-hydral Tab 25mgtablet25 mgoralNu Pharm Inc1992-12-312012-09-04Canada
Nu-hydral Tab 50 mgtablet50 mgoralNu Pharm Inc1992-12-312012-09-04Canada
PMS-hydralazinetablet50 mgoralPharmascience IncNot applicableNot applicableCanada
PMS-hydralazinetablet25 mgoralPharmascience IncNot applicableNot applicableCanada
PMS-hydralazinetablet10 mgoralPharmascience IncNot applicableNot applicableCanada
Approved Generic Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Hydralazinetablet25 mg/1oralCardinal Health2009-09-14Not applicableUs
Hydralazinetablet50 mg/1oralCardinal Health2009-09-14Not applicableUs
Hydralazine Hydrochloridetablet25 mg/1oralA S Medication Solutions Llc2009-06-01Not applicableUs
Hydralazine Hydrochloridetablet50 mg/1oralREMEDYREPACK INC.2013-07-01Not applicableUs
Hydralazine Hydrochloridetablet, film coated50 mg/1oralPd Rx Pharmaceuticals, Inc.2007-04-06Not applicableUs
Hydralazine Hydrochloridetablet, film coated10 mg/1oralPhysicians Total Care, Inc.2007-07-13Not applicableUs
Hydralazine Hydrochloridetablet25 mg/1oralCardinal Health2009-12-07Not applicableUs
Hydralazine Hydrochloridetablet100 mg/1oralGolden State Medical Supply, Inc.2008-12-15Not applicableUs
Hydralazine Hydrochloridetablet25 mg/1oralCadila Pharmaceuticals Limited2014-09-24Not applicableUs
Hydralazine Hydrochloridetablet50 mg/1oralMc Kesson Contract Packaging2011-10-25Not applicableUs
Hydralazine Hydrochloridetablet50 mg/1oralRebel Distributors Corp2008-09-12Not applicableUs
Hydralazine Hydrochlorideinjection, solution20 mg/mLintramuscular; intravenousAmerican Regent, Inc.1997-06-30Not applicableUs
Hydralazine Hydrochloridetablet, film coated25 mg/1oralAphena Pharma Solutions Tennessee, Llc2007-04-06Not applicableUs
Hydralazine Hydrochloridetablet25 mg/1oralPliva Inc.1990-09-30Not applicableUs
Hydralazine Hydrochloridetablet, film coated10 mg/1oralHeritage Pharmaceuticals Inc2007-04-06Not applicableUs
Hydralazine Hydrochloridetablet50 mg/1oralREMEDYREPACK INC.2014-06-11Not applicableUs
Hydralazine Hydrochlorideinjection20 mg/mLintramuscular; intravenousCardinal Health2009-05-01Not applicableUs
Hydralazine Hydrochloridetablet10 mg/1oralCardinal Health2010-09-10Not applicableUs
Hydralazine Hydrochloridetablet, film coated50 mg/1oralSt Marys Medical Park Pharmacy2014-04-21Not applicableUs
Hydralazine Hydrochloridetablet100 mg/1oralCadila Pharmaceuticals Limited2014-09-24Not applicableUs
Hydralazine Hydrochloridetablet50 mg/1oralStrides Shasun Limited2013-06-30Not applicableUs
Hydralazine Hydrochloridetablet50 mg/1oralREMEDYREPACK INC.2011-12-09Not applicableUs
Hydralazine Hydrochloridetablet, film coated50 mg/1oralUnit Dose Services2007-04-06Not applicableUs
Hydralazine Hydrochloridetablet25 mg/1oralCamber Pharmaceuticals2010-01-01Not applicableUs
Hydralazine Hydrochloridetablet50 mg/1oralState of Florida DOH Central Pharmacy2013-01-01Not applicableUs
Hydralazine Hydrochloridetablet, film coated10 mg/1oralCardinal Health2007-04-06Not applicableUs
Hydralazine Hydrochloridetablet100 mg/1oralClinical Solutions Wholesale2009-06-01Not applicableUs
Hydralazine Hydrochloridetablet, film coated25 mg/1oralAmerican Health Packaging2008-03-18Not applicableUs
Hydralazine Hydrochloridetablet, film coated100 mg/1oralAmerican Health Packaging2011-09-19Not applicableUs
Hydralazine Hydrochloridetablet, film coated25 mg/1oralMajor Pharmaceuticals2015-05-14Not applicableUs
Hydralazine Hydrochloridetablet25 mg/1oralA S Medication Solutions Llc2010-01-01Not applicableUs
Hydralazine Hydrochloridetablet50 mg/1oralREMEDYREPACK INC.2013-05-28Not applicableUs
Hydralazine Hydrochlorideinjection, solution20 mg/mLintramuscular; intravenousX Gen Pharmaceuticals, Inc.2015-06-29Not applicableUs
Hydralazine Hydrochloridetablet, film coated50 mg/1oralPhysicians Total Care, Inc.2007-09-17Not applicableUs
Hydralazine Hydrochlorideinjection, solution20 mg/mLintramuscular; intravenousCardinal Health1997-06-30Not applicableUs
Hydralazine Hydrochloridetablet50 mg/1oralGolden State Medical Supply, Inc.2008-12-15Not applicableUs
Hydralazine Hydrochloridetablet50 mg/1oralMc Kesson Packaging Services A Business Unit Of Mc Kesson Corporation1990-09-30Not applicableUs
Hydralazine Hydrochloridetablet25 mg/1oralMc Kesson Contract Packaging2011-10-25Not applicableUs
Hydralazine Hydrochloridetablet25 mg/1oralRebel Distributors Corp2008-09-12Not applicableUs
Hydralazine Hydrochloridetablet, film coated25 mg/1oralREMEDYREPACK INC.2011-04-28Not applicableUs
Hydralazine Hydrochloridetablet, film coated25 mg/1oralUnit Dose Services2007-04-06Not applicableUs
Hydralazine Hydrochloridetablet10 mg/1oralCamber Pharmaceuticals2010-01-01Not applicableUs
Hydralazine Hydrochloridetablet, film coated50 mg/1oralAidarex Pharmaceuticals LLC2007-04-06Not applicableUs
Hydralazine Hydrochloridetablet50 mg/1oralCardinal Health2008-03-18Not applicableUs
Hydralazine Hydrochloridetablet50 mg/1oralClinical Solutions Wholesale2009-06-01Not applicableUs
Hydralazine Hydrochloridetablet, film coated10 mg/1oralREMEDYREPACK INC.2015-06-12Not applicableUs
Hydralazine Hydrochloridetablet, film coated10 mg/1oralAmerican Health Packaging2010-09-10Not applicableUs
Hydralazine Hydrochloridetablet, film coated10 mg/1oralMajor Pharmaceuticals2015-05-14Not applicableUs
Hydralazine Hydrochloridetablet100 mg/1oralPar Pharmaceutical, Inc.1983-09-27Not applicableUs
Hydralazine Hydrochloridetablet25 mg/1oralREMEDYREPACK INC.2013-06-03Not applicableUs
Hydralazine Hydrochloridetablet10 mg/1oralLake Erie Medical DBA Quality Care Products LLC2009-06-01Not applicableUs
Hydralazine Hydrochloridetablet, film coated25 mg/1oralPhysicians Total Care, Inc.2007-09-17Not applicableUs
Hydralazine Hydrochloridetablet25 mg/1oralCardinal Health2011-05-13Not applicableUs
Hydralazine Hydrochloridetablet25 mg/1oralGolden State Medical Supply, Inc.2008-12-15Not applicableUs
Hydralazine Hydrochloridetablet25 mg/1oralMc Kesson Packaging Services A Business Unit Of Mc Kesson Corporation1990-09-30Not applicableUs
Hydralazine Hydrochloridetablet10 mg/1oralMc Kesson Contract Packaging2011-12-02Not applicableUs
Hydralazine Hydrochloridetablet10 mg/1oralRebel Distributors Corp2008-09-12Not applicableUs
Hydralazine Hydrochloridetablet, film coated25 mg/1oralREMEDYREPACK INC.2011-04-19Not applicableUs
Hydralazine Hydrochloridetablet, film coated10 mg/1oralUnit Dose Services2007-04-06Not applicableUs
Hydralazine Hydrochloridetablet10 mg/1oralREMEDYREPACK INC.2013-03-18Not applicableUs
Hydralazine Hydrochlorideinjection, solution20 mg/mLintramuscular; intravenousGeneral Injectables & Vaccines, Inc2010-08-01Not applicableUs
Hydralazine Hydrochloridetablet25 mg/1oralCardinal Health2008-03-18Not applicableUs
Hydralazine Hydrochloridetablet25 mg/1oralClinical Solutions Wholesale2009-06-01Not applicableUs
Hydralazine Hydrochloridetablet25 mg/1oralREMEDYREPACK INC.2014-12-18Not applicableUs
Hydralazine Hydrochloridetablet10 mg/1oralAscend Laboratories, LLC2010-05-24Not applicableUs
Hydralazine Hydrochloridetablet100 mg/1oralNcs Health Care Of Ky, Inc Dba Vangard Labs1983-09-27Not applicableUs
Hydralazine Hydrochloridetablet, film coated100 mg/1oralPhysicians Total Care, Inc.2007-04-10Not applicableUs
Hydralazine Hydrochloridetablet10 mg/1oralCardinal Health2011-05-13Not applicableUs
Hydralazine Hydrochloridetablet10 mg/1oralGolden State Medical Supply, Inc.2008-12-15Not applicableUs
Hydralazine Hydrochloridetablet100 mg/1oralbryant ranch prepack2010-01-01Not applicableUs
Hydralazine Hydrochloridetablet100 mg/1oralGlenmark Pharmaceuticals Inc., Usa2009-06-01Not applicableUs
Hydralazine Hydrochlorideinjection20 mg/mLintramuscular; intravenousAkorn, Inc.2009-05-01Not applicableUs
Hydralazine Hydrochloridetablet10 mg/1oralPar Pharmaceutical, Inc.1982-10-05Not applicableUs
Hydralazine Hydrochloridetablet10 mg/1oralREMEDYREPACK INC.2013-05-02Not applicableUs
Hydralazine Hydrochloridetablet25 mg/1oralLake Erie Medical DBA Quality Care Products LLC2009-06-01Not applicableUs
Hydralazine Hydrochlorideinjection, solution20 mg/mLintramuscular; intravascularGeneral Injectables & Vaccines, Inc2011-10-19Not applicableUs
Hydralazine Hydrochloridetablet10 mg/1oralClinical Solutions Wholesale2009-06-01Not applicableUs
Hydralazine Hydrochloridetablet25 mg/1oralREMEDYREPACK INC.2014-10-24Not applicableUs
Hydralazine Hydrochloridetablet25 mg/1oralAscend Laboratories, LLC2010-05-24Not applicableUs
Hydralazine Hydrochloridetablet25 mg/1oralREMEDYREPACK INC.2016-04-13Not applicableUs
Hydralazine Hydrochloridetablet50 mg/1oralNcs Health Care Of Ky, Inc Dba Vangard Labs1980-02-27Not applicableUs
Hydralazine Hydrochloridetablet25 mg/1oralREMEDYREPACK INC.2010-11-18Not applicableUs
Hydralazine Hydrochloridetablet10 mg/1oralPliva Inc.1990-09-30Not applicableUs
Hydralazine Hydrochloridetablet, film coated100 mg/1oralHeritage Pharmaceuticals Inc2007-04-06Not applicableUs
Hydralazine Hydrochloridetablet50 mg/1oralA S Medication Solutions Llc2010-01-01Not applicableUs
Hydralazine Hydrochloridetablet50 mg/1oralCardinal Health2011-05-13Not applicableUs
Hydralazine Hydrochloridetablet100 mg/1oralStrides Pharma Inc2013-05-04Not applicableUs
Hydralazine Hydrochloridetablet50 mg/1oralbryant ranch prepack2010-01-01Not applicableUs
Hydralazine Hydrochloridetablet50 mg/1oralGlenmark Pharmaceuticals Inc., Usa2009-06-01Not applicableUs
Hydralazine Hydrochlorideinjection20 mg/mLintramuscular; intravenousAkorn, Inc.2013-02-21Not applicableUs
Hydralazine Hydrochloridetablet50 mg/1oralPar Pharmaceutical, Inc.1980-02-27Not applicableUs
Hydralazine Hydrochloridetablet50 mg/1oralMylan Institutional Inc.2007-12-26Not applicableUs
Hydralazine Hydrochloridetablet50 mg/1oralLake Erie Medical DBA Quality Care Products LLC2010-01-01Not applicableUs
Hydralazine Hydrochloridetablet10 mg/1oralREMEDYREPACK INC.2014-07-09Not applicableUs
Hydralazine Hydrochlorideinjection20 mg/mLintramuscular; intravenousCardinal Health2011-01-31Not applicableUs
Hydralazine Hydrochloridetablet50 mg/1oralREMEDYREPACK INC.2014-09-12Not applicableUs
Hydralazine Hydrochloridetablet50 mg/1oralAscend Laboratories, LLC2009-11-24Not applicableUs
Hydralazine Hydrochloridetablet50 mg/1oralREMEDYREPACK INC.2016-04-14Not applicableUs
Hydralazine Hydrochloridetablet25 mg/1oralNcs Health Care Of Ky, Inc Dba Vangard Labs1980-02-27Not applicableUs
Hydralazine Hydrochloridetablet, film coated25 mg/1oralSafecor Health, LLC2014-09-30Not applicableUs
Hydralazine Hydrochloridetablet100 mg/1oralPliva Inc.1990-09-30Not applicableUs
Hydralazine Hydrochloridetablet, film coated50 mg/1oralHeritage Pharmaceuticals Inc2007-04-06Not applicableUs
Hydralazine Hydrochloridetablet, film coated100 mg/1oralMajor Pharmaceuticals2015-05-14Not applicableUs
Hydralazine Hydrochloridetablet25 mg/1oralPar Pharmaceutical, Inc.1980-02-27Not applicableUs
Hydralazine Hydrochloridetablet25 mg/1oralMylan Institutional Inc.2007-12-26Not applicableUs
Hydralazine Hydrochloridetablet100 mg/1oralCamber Pharmaceuticals2010-01-01Not applicableUs
Hydralazine Hydrochloridetablet25 mg/1oralA S Medication Solutions Llc2010-01-01Not applicableUs
Hydralazine Hydrochloridetablet, film coated10 mg/1oralCardinal Health2007-04-06Not applicableUs
Hydralazine Hydrochloridetablet50 mg/1oralStrides Pharma Inc2013-05-04Not applicableUs
Hydralazine Hydrochlorideinjection20 mg/mLintramuscular; intravenousFresenius Kabi USA, LLC2001-09-05Not applicableUs
Hydralazine Hydrochloridetablet25 mg/1oralGlenmark Pharmaceuticals Inc., Usa2009-06-01Not applicableUs
Hydralazine Hydrochloridetablet100 mg/1oralRebel Distributors Corp2008-09-12Not applicableUs
Hydralazine Hydrochloridetablet50 mg/1oralA S Medication Solutions Llc2010-01-01Not applicableUs
Hydralazine Hydrochloridetablet25 mg/1oralREMEDYREPACK INC.2013-05-13Not applicableUs
Hydralazine Hydrochloridetablet, film coated50 mg/1oralAphena Pharma Solutions Tennessee, Llc2007-04-06Not applicableUs
Hydralazine Hydrochlorideinjection, solution20 mg/mLintramuscular; intravenousPhysicians Total Care, Inc.2011-05-17Not applicableUs
Hydralazine Hydrochloridetablet10 mg/1oralCardinal Health2009-12-07Not applicableUs
Hydralazine Hydrochloridetablet, film coated10 mg/1oralSt Marys Medical Park Pharmacy2014-04-21Not applicableUs
Hydralazine Hydrochloridetablet50 mg/1oralCadila Pharmaceuticals Limited2014-09-24Not applicableUs
Hydralazine Hydrochloridetablet25 mg/1oralStrides Shasun Limited2013-06-30Not applicableUs
Hydralazine Hydrochloridetablet100 mg/1oralREMEDYREPACK INC.2014-06-11Not applicableUs
Hydralazine Hydrochlorideinjection20 mg/mLintramuscular; intravenousCardinal Health2009-05-01Not applicableUs
Hydralazine Hydrochlorideinjection20 mg/mLintramuscular; intravenousCardinal Health2011-01-31Not applicableUs
Hydralazine Hydrochloridetablet, film coated25 mg/1oralSt Marys Medical Park Pharmacy2014-04-21Not applicableUs
Hydralazine Hydrochloridetablet100 mg/1oralAscend Laboratories, LLC2010-05-24Not applicableUs
Hydralazine Hydrochloridetablet100 mg/1oralStrides Shasun Limited2013-06-30Not applicableUs
Hydralazine Hydrochloridetablet10 mg/1oralNcs Health Care Of Ky, Inc Dba Vangard Labs1982-10-05Not applicableUs
Hydralazine Hydrochloridetablet, film coated100 mg/1oralAphena Pharma Solutions Tennessee, Llc2007-04-06Not applicableUs
Hydralazine Hydrochloridetablet50 mg/1oralPliva Inc.1990-09-30Not applicableUs
Hydralazine Hydrochloridetablet, film coated25 mg/1oralHeritage Pharmaceuticals Inc2007-04-06Not applicableUs
Hydralazine Hydrochloridetablet, film coated50 mg/1oralMajor Pharmaceuticals2015-05-14Not applicableUs
Hydralazine Hydrochloridetablet10 mg/1oralREMEDYREPACK INC.2011-11-17Not applicableUs
Hydralazine Hydrochloridetablet10 mg/1oralMylan Institutional Inc.2007-12-26Not applicableUs
Hydralazine Hydrochloridetablet50 mg/1oralCamber Pharmaceuticals2010-01-01Not applicableUs
Hydralazine Hydrochloridetablet50 mg/1oralState of Florida DOH Central Pharmacy2014-11-01Not applicableUs
Hydralazine Hydrochloridetablet, film coated100 mg/1oralCardinal Health2007-04-06Not applicableUs
Hydralazine Hydrochloridetablet25 mg/1oralStrides Pharma Inc2013-05-04Not applicableUs
Hydralazine Hydrochloridetablet, film coated50 mg/1oralAmerican Health Packaging2008-03-18Not applicableUs
Hydralazine Hydrochloridetablet10 mg/1oralGlenmark Pharmaceuticals Inc., Usa2009-06-01Not applicableUs
Approved Over the Counter ProductsNot Available
Unapproved/Other Products Not Available
International Brands
NameCompany
AlphapressAlphapharm
AprezinJohnson
Cesoline WPharmasant
Cesoline YPharmasant
DiazideThe Central
HidralBiocontrol
PressfallNisshin Seiyaku
SerpathiazideWashington
Brand mixtures
NameLabellerIngredients
BidilArbor Pharmaceuticals
Ser-AP-ES TabNovartis Pharmaceuticals Canada Inc
Salts
Name/CASStructureProperties
Hydralazine hydrochloride
Thumb
  • InChI Key: ZUXNZUWOTSUBMN-UHFFFAOYSA-N
  • Monoisotopic Mass: 196.051574015
  • Average Mass: 196.637
DBSALT000792
Categories
UNII26NAK24LS8
CAS number86-54-4
WeightAverage: 160.1759
Monoisotopic: 160.074896276
Chemical FormulaC8H8N4
InChI KeyInChIKey=RPTUSVTUFVMDQK-UHFFFAOYSA-N
InChI
InChI=1S/C8H8N4/c9-11-8-7-4-2-1-3-6(7)5-10-12-8/h1-5H,9H2,(H,11,12)
IUPAC Name
1-hydrazinylphthalazine
SMILES
NNC1=NN=CC2=CC=CC=C12
Taxonomy
DescriptionThis compound belongs to the class of organic compounds known as phthalazines. These are compounds containing a phthalazine moiety, which consists of a benzene ring fused to a pyridazine, forming a 2,3-benzodiazine skeleton.
KingdomOrganic compounds
Super ClassOrganoheterocyclic compounds
ClassNaphthyridines
Sub ClassPhthalazines
Direct ParentPhthalazines
Alternative Parents
Substituents
  • Phthalazine
  • Aminopyridazine
  • Imidolactam
  • Benzenoid
  • Pyridazine
  • Heteroaromatic compound
  • Azacycle
  • Hydrocarbon derivative
  • Organonitrogen compound
  • Hydrazine derivative
  • Aromatic heteropolycyclic compound
Molecular FrameworkAromatic heteropolycyclic compounds
External Descriptors
Pharmacology
IndicationFor the treatment of essential hypertension, alone or as an adjunct. Also for the management of severe hypertension when the drug cannot be given orally or when blood pressure must be lowered immediately, congestive heart failure (in combination with cardiac glycosides and diuretics and/or with isosorbide dinitrate), and hypertension secondary to pre-eclampsia/eclampsia.
PharmacodynamicsA vasodilator, hydralazine works by relaxing blood vessels (arterioles more than venules) and increasing the supply of blood and oxygen to the heart while reducing its workload. It also functions as an antioxidant. It inhibits membrane-bound enzymes that form reactive oxygen species, such as superoxides. Excessive superoxide counteracts NO-induced vasodilation. It is commonly used in the condition of pregnancy called preeclampsia.
Mechanism of actionAlthough the precise mechanism of action of hydralazine is not fully understood, the major effects are on the cardiovascular system. Hydralazine apparently lowers blood pressure by exerting a peripheral vasodilating effect through a direct relaxation of vascular smooth muscle. It has also been suggested that cyclic 3',5'-adenosine monophosphate (cyclic AMP) mediates, at least partly, the relaxation of arterial smooth muscle by altering cellular calcium metabolism, which interferes with the calcium movements within the vascular smooth muscle that are responsible for initiating or maintaining the contractile state. In hypertensive patients, the hydralazine-induced decrease in blood pressure is accompanied by increased heart rate, cardiac output, and stroke volume, probably because of a reflex response to decreased peripheral resistance. The drug has no direct effect on the heart. Hydralazine may increase pulmonary arterial pressure, as well as coronary, splanchnic, cerebral, and renal blood flow. The preferential dilatation of arterioles, as compared to veins, minimizes postural hypotension and promotes the increase in cardiac output. Hydralazine usually increases renin activity in plasma, presumably as a result of increased secretion of renin by the renal juxtaglomerular cells in response to reflex sympathetic discharge. This increase in renin activity leads to the production of angiotensin II, which then causes stimulation of aldosterone and consequent sodium reabsorption. Tolerance to the antihypertensive effect of the drug develops during prolonged therapy, especially if a diuretic is not administered concurrently. In patients with CHF, hydralazine decreases systemic vascular resistance and increases cardiac output.
Related Articles
AbsorptionHydralazine is rapidly and extensively absorbed (up to 90%) from the gastrointestinal tract and undergoes extensive first-pass metabolism by genetic polymorphic acetylation. Oral bioavailability of hydralazine is dependent upon acetylator phenotype. Bioavailability is approximately 31% in slow acetylators and 10% in fast acetylators.
Volume of distributionNot Available
Protein binding87%
Metabolism

Hydralazine, when administered orally, undergoes extensive first-pass metabolism by genetic polymorphic acetylation, which is responsible for a threefold range of oral bioavailability. Intravenously administered hydralazine does not undergo first-pass metabolism and, therefore, is not affected by acetylator phenotype. After the drug reaches the systemic circulation, it is combined with endogenous aldehydes and ketones, including pyruvic acid, to form hydrazone metabolites. The active metabolites, hydralazine acetonide hydrazone and hydralazine pyruvate hydrazone, are equipotent with the parent, hydralazine.

SubstrateEnzymesProduct
Hydralazine
Not Available
Hydralazine acetone hydrazoneDetails
Hydralazine
Not Available
Hydralazine pyruvate hydrazoneDetails
Route of eliminationHydralazine undergoes extensive hepatic metabolism; it is excreted mainly in the form of metabolites in the urine.
Half life3 to 7 hours
ClearanceNot Available
ToxicityOral LD50 in rats: 173 and 187 mg/kg
Affected organisms
  • Humans and other mammals
PathwaysNot Available
SNP Mediated EffectsNot Available
SNP Mediated Adverse Drug ReactionsNot Available
ADMET
Predicted ADMET features
PropertyValueProbability
Human Intestinal Absorption+0.9854
Blood Brain Barrier+0.9487
Caco-2 permeable+0.8867
P-glycoprotein substrateNon-substrate0.686
P-glycoprotein inhibitor INon-inhibitor0.9478
P-glycoprotein inhibitor IINon-inhibitor0.9826
Renal organic cation transporterNon-inhibitor0.8279
CYP450 2C9 substrateNon-substrate0.8971
CYP450 2D6 substrateNon-substrate0.9116
CYP450 3A4 substrateNon-substrate0.7467
CYP450 1A2 substrateInhibitor0.9106
CYP450 2C9 inhibitorNon-inhibitor0.9071
CYP450 2D6 inhibitorNon-inhibitor0.9231
CYP450 2C19 inhibitorNon-inhibitor0.9025
CYP450 3A4 inhibitorInhibitor0.526
CYP450 inhibitory promiscuityLow CYP Inhibitory Promiscuity0.5294
Ames testAMES toxic0.9107
CarcinogenicityNon-carcinogens0.7719
BiodegradationNot ready biodegradable1.0
Rat acute toxicity3.2187 LD50, mol/kg Not applicable
hERG inhibition (predictor I)Weak inhibitor0.9253
hERG inhibition (predictor II)Non-inhibitor0.8589
ADMET data is predicted using admetSAR, a free tool for evaluating chemical ADMET properties. (23092397 )
Pharmacoeconomics
ManufacturersNot Available
Packagers
Dosage forms
FormRouteStrength
Solutionintravenous20 mg
Tablet, film coatedoral
Tabletoral10 mg
Tabletoral25 mg
Tabletoral50 mg
Injectionintramuscular; intravenous20 mg/mL
Injection, solutionintramuscular; intravascular20 mg/mL
Injection, solutionintramuscular; intravenous20 mg/mL
Tabletoral10 mg/1
Tabletoral100 mg/1
Tabletoral25 mg/1
Tabletoral50 mg/1
Tablet, film coatedoral10 mg/1
Tablet, film coatedoral100 mg/1
Tablet, film coatedoral25 mg/1
Tablet, film coatedoral50 mg/1
Tabletoral
Prices
Unit descriptionCostUnit
Hydralazine 20 mg/ml vial18.0USD ml
Hydralazine 100 mg tablet1.65USD tablet
Hydralazine-HCTZ 50-50 mg capsule1.2USD capsule
HydrALAZINE HCl 100 mg tablet1.05USD tablet
Hydralazine-HCTZ 25-25 mg capsule0.81USD capsule
Hydralazine-HCTZ 100-50 mg capsule0.75USD capsule
HydrALAZINE HCl 50 mg tablet0.67USD tablet
Apresoline 50 mg tablet0.65USD tablet
HydrALAZINE HCl 25 mg tablet0.53USD tablet
HydrALAZINE HCl 10 mg tablet0.47USD tablet
Hydralazine 50 mg tablet0.44USD tablet
Hydralazine 25 mg tablet0.35USD tablet
Apo-Hydralazine 50 mg Tablet0.29USD tablet
Novo-Hylazin 50 mg Tablet0.29USD tablet
Apo-Hydralazine 25 mg Tablet0.24USD tablet
Hydralazine 10 mg tablet0.22USD tablet
Apo-Hydralazine 10 mg Tablet0.11USD tablet
Novo-Hylazin 10 mg Tablet0.11USD tablet
DrugBank does not sell nor buy drugs. Pricing information is supplied for informational purposes only.
Patents
Patent NumberPediatric ExtensionApprovedExpires (estimated)
US6465463 No2000-09-082020-09-08Us
US6784177 No2000-09-082020-09-08Us
Properties
StateSolid
Experimental Properties
PropertyValueSource
melting point172-173 °CU.S. Patent 2,484,029.
logP1.00SANGSTER (1993)
Predicted Properties
PropertyValueSource
Water Solubility2.61 mg/mLALOGPS
logP0.66ALOGPS
logP0.75ChemAxon
logS-1.8ALOGPS
pKa (Strongest Acidic)17.69ChemAxon
pKa (Strongest Basic)6.4ChemAxon
Physiological Charge0ChemAxon
Hydrogen Acceptor Count4ChemAxon
Hydrogen Donor Count2ChemAxon
Polar Surface Area63.83 Å2ChemAxon
Rotatable Bond Count1ChemAxon
Refractivity50.23 m3·mol-1ChemAxon
Polarizability16.06 Å3ChemAxon
Number of Rings2ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleYesChemAxon
Spectra
Mass Spec (NIST)Not Available
SpectraNot Available
References
Synthesis Reference

U.S. Patent 2,484,029.

General References
  1. Kandler MR, Mah GT, Tejani AM, Stabler SN: Hydralazine for essential hypertension. Cochrane Database Syst Rev. 2010 Aug 4;(8):CD004934. doi: 10.1002/14651858.CD004934.pub3. [PubMed:20687078 ]
External Links
ATC CodesC02DB02C02LG02
AHFS Codes
  • 24:08.20
PDB EntriesNot Available
FDA labelNot Available
MSDSDownload (73.7 KB)
Interactions
Drug Interactions
Drug
AldesleukinThe risk or severity of adverse effects can be increased when Aldesleukin is combined with Hydralazine.
AlfuzosinAlfuzosin may increase the hypotensive activities of Hydralazine.
AmifostineHydralazine may increase the hypotensive activities of Amifostine.
BrimonidineBrimonidine may increase the antihypertensive activities of Hydralazine.
ButabarbitalButabarbital may increase the hypotensive activities of Hydralazine.
ButethalButethal may increase the hypotensive activities of Hydralazine.
CelecoxibCelecoxib may decrease the antihypertensive activities of Hydralazine.
DapoxetineDapoxetine may increase the orthostatic hypotensive activities of Hydralazine.
DiazoxideDiazoxide may increase the hypotensive activities of Hydralazine.
DiclofenacDiclofenac may decrease the antihypertensive activities of Hydralazine.
DiflunisalDiflunisal may decrease the antihypertensive activities of Hydralazine.
DuloxetineHydralazine may increase the orthostatic hypotensive activities of Duloxetine.
EtodolacEtodolac may decrease the antihypertensive activities of Hydralazine.
FenoprofenFenoprofen may decrease the antihypertensive activities of Hydralazine.
FloctafenineFloctafenine may decrease the antihypertensive activities of Hydralazine.
FlurbiprofenFlurbiprofen may decrease the antihypertensive activities of Hydralazine.
HeptabarbitalHeptabarbital may increase the hypotensive activities of Hydralazine.
HexobarbitalHexobarbital may increase the hypotensive activities of Hydralazine.
IbuprofenIbuprofen may decrease the antihypertensive activities of Hydralazine.
IndomethacinIndomethacin may decrease the antihypertensive activities of Hydralazine.
InfliximabInfliximab may decrease the antihypertensive activities of Hydralazine.
KetoprofenKetoprofen may decrease the antihypertensive activities of Hydralazine.
KetorolacKetorolac may decrease the antihypertensive activities of Hydralazine.
LevodopaHydralazine may increase the orthostatic hypotensive activities of Levodopa.
Mefenamic acidMefenamic acid may decrease the antihypertensive activities of Hydralazine.
MeloxicamMeloxicam may decrease the antihypertensive activities of Hydralazine.
MethohexitalMethohexital may increase the hypotensive activities of Hydralazine.
MethylphenidateMethylphenidate may decrease the antihypertensive activities of Hydralazine.
MolsidomineMolsidomine may increase the hypotensive activities of Hydralazine.
MoxonidineMoxonidine may increase the hypotensive activities of Hydralazine.
NabumetoneNabumetone may decrease the antihypertensive activities of Hydralazine.
NaproxenNaproxen may decrease the antihypertensive activities of Hydralazine.
NicorandilNicorandil may increase the hypotensive activities of Hydralazine.
ObinutuzumabHydralazine may increase the hypotensive activities of Obinutuzumab.
OxaprozinOxaprozin may decrease the antihypertensive activities of Hydralazine.
PentobarbitalPentobarbital may increase the hypotensive activities of Hydralazine.
PentoxifyllinePentoxifylline may increase the hypotensive activities of Hydralazine.
PhenelzinePhenelzine may increase the orthostatic hypotensive activities of Hydralazine.
PiroxicamPiroxicam may decrease the antihypertensive activities of Hydralazine.
PrimidonePrimidone may increase the hypotensive activities of Hydralazine.
QuinineQuinine may increase the hypotensive activities of Hydralazine.
RisperidoneHydralazine may increase the hypotensive activities of Risperidone.
RituximabHydralazine may increase the hypotensive activities of Rituximab.
SecobarbitalSecobarbital may increase the hypotensive activities of Hydralazine.
SulindacSulindac may decrease the antihypertensive activities of Hydralazine.
TadalafilTadalafil may increase the antihypertensive activities of Hydralazine.
Tiaprofenic acidTiaprofenic acid may decrease the antihypertensive activities of Hydralazine.
TolmetinTolmetin may decrease the antihypertensive activities of Hydralazine.
TranylcypromineTranylcypromine may increase the orthostatic hypotensive activities of Hydralazine.
TreprostinilTreprostinil may increase the hypotensive activities of Hydralazine.
ValsartanThe risk or severity of adverse effects can be increased when Valsartan is combined with Hydralazine.
VardenafilVardenafil may increase the antihypertensive activities of Hydralazine.
YohimbineYohimbine may decrease the antihypertensive activities of Hydralazine.
Food InteractionsNot Available

Targets

Kind
Protein
Organism
Human
Pharmacological action
yes
Actions
inhibitor
General Function:
Tryptamine:oxygen oxidoreductase (deaminating) activity
Specific Function:
Cell adhesion protein that participates in lymphocyte extravasation and recirculation by mediating the binding of lymphocytes to peripheral lymph node vascular endothelial cells in an L-selectin-independent fashion. Has semicarbazide-sensitive (SSAO) monoamine oxidase activity. May play a role in adipogenesis.
Gene Name:
AOC3
Uniprot ID:
Q16853
Molecular Weight:
84621.27 Da
References
  1. Claud P, Padovani P, Guichard JP, Artur Y, Laine R: Involvement of semicarbazide-sensitive amine oxidase in tresperimus metabolism in human and in rat. Drug Metab Dispos. 2001 May;29(5):735-41. [PubMed:11302941 ]
  2. Vidrio H, Medina M, Gonzalez-Romo P, Lorenzana-Jimenez M, Diaz-Arista P, Baeza A: Semicarbazide-sensitive amine oxidase substrates potentiate hydralazine hypotension: possible role of hydrogen peroxide. J Pharmacol Exp Ther. 2003 Nov;307(2):497-504. Epub 2003 Sep 11. [PubMed:12970383 ]
  3. Vidrio H: Semicarbazide-sensitive amine oxidase: role in the vasculature and vasodilation after in situ inhibition. Auton Autacoid Pharmacol. 2003 Oct-Dec;23(5-6):275-83. [PubMed:15255812 ]
  4. Vidrio H, Medina M: 2-bromoethylamine, a suicide inhibitor of semicarbazide-sensitive amine oxidase, increases hydralazine hypotension in rats. J Cardiovasc Pharmacol. 2005 Sep;46(3):316-24. [PubMed:16116337 ]
  5. Vidrio H, Medina M: Hypotensive effect of hydroxylamine, an endogenous nitric oxide donor and SSAO inhibitor. J Neural Transm (Vienna). 2007;114(6):863-5. Epub 2007 Mar 26. [PubMed:17385063 ]
  6. Gronvall JL, Garpenstrand H, Oreland L, Ekblom J: An autoradiographic method of visualising semicarbazide-sensitive amine oxidase activity in mouse tissue sections. Neurobiology (Bp). 2000;8(2):167-77. [PubMed:11061213 ]
  7. Gronvall JL, Garpenstrand H, Oreland L, Ekblom J: Autoradiographic imaging of formaldehyde adducts in mice: possible relevance for vascular damage in diabetes. Life Sci. 1998;63(9):759-68. [PubMed:9740313 ]
  8. Lizcano JM, Fernandez de Arriba A, Tipton KF, Unzeta M: Inhibition of bovine lung semicarbazide-sensitive amine oxidase (SSAO) by some hydrazine derivatives. Biochem Pharmacol. 1996 Jul 26;52(2):187-95. [PubMed:8694842 ]
  9. Lyles GA, McDougall SA: The enhanced daily excretion of urinary methylamine in rats treated with semicarbazide or hydralazine may be related to the inhibition of semicarbazide-sensitive amine oxidase activities. J Pharm Pharmacol. 1989 Feb;41(2):97-100. [PubMed:2568436 ]
  10. Barrand MA, Callingham BA: The interaction of hydralazine with a semicarbazide-sensitive amine oxidase in brown adipose tissue of the rat. Its use as a radioactive ligand for the enzyme. Biochem J. 1985 Dec 1;232(2):415-23. [PubMed:4091799 ]
  11. Barrand MA, Fox SA: Amine oxidase activities in brown adipose tissue of the rat: identification of semicarbazide-sensitive (clorgyline-resistant) activity at the fat cell membrane. J Pharm Pharmacol. 1984 Oct;36(10):652-8. [PubMed:6150080 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Procollagen-proline 4-dioxygenase activity
Specific Function:
Catalyzes the post-translational formation of 4-hydroxyproline in -Xaa-Pro-Gly- sequences in collagens and other proteins.
Gene Name:
P4HA1
Uniprot ID:
P13674
Molecular Weight:
61048.775 Da
References
  1. Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. [PubMed:11752352 ]
  2. Knowles HJ, Tian YM, Mole DR, Harris AL: Novel mechanism of action for hydralazine: induction of hypoxia-inducible factor-1alpha, vascular endothelial growth factor, and angiogenesis by inhibition of prolyl hydroxylases. Circ Res. 2004 Jul 23;95(2):162-9. Epub 2004 Jun 10. [PubMed:15192023 ]
  3. Murad S, Tajima S, Pinnell SR: A paradoxical effect of hydralazine on prolyl and lysyl hydroxylase activities in cultured human skin fibroblasts. Arch Biochem Biophys. 1985 Sep;241(2):356-63. [PubMed:2994564 ]
  4. Chen KH, Paz MA, Gallop PM: Collagen prolyl hydroxylation in WI-38 fibroblast cultures: action of hydralazine. In Vitro. 1977 Jan;13(1):49-54. [PubMed:856725 ]

Enzymes

Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Vitamin d3 25-hydroxylase activity
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It performs a variety of oxidation reactions (e.g. caffeine 8-oxidation, omeprazole sulphoxidation, midazolam 1'-hydroxylation and midazolam 4-hydroxylation) of structurally unrelated compounds, including steroids, fatty acids, and xenobiot...
Gene Name:
CYP3A4
Uniprot ID:
P08684
Molecular Weight:
57342.67 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
  2. Zhao XJ, Ishizaki T: Metabolic interactions of selected antimalarial and non-antimalarial drugs with the major pathway (3-hydroxylation) of quinine in human liver microsomes. Br J Clin Pharmacol. 1997 Nov;44(5):505-11. [PubMed:9384469 ]
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Drug created on May 16, 2007 14:38 / Updated on July 28, 2016 01:50