You are using an unsupported browser. Please upgrade your browser to a newer version to get the best experience on DrugBank.
Identification
NameHydralazine
Accession NumberDB01275
TypeSmall Molecule
GroupsApproved
Description

A direct-acting vasodilator that is used as an antihypertensive agent. [PubChem]

Structure
Thumb
Synonyms
SynonymLanguageCode
(1Z)-1(2H)-Phthalazinone hydrazoneNot AvailableNot Available
(2H)-Phthalazinone hydrazoneNot AvailableNot Available
1-HydrazinophthalazineNot AvailableNot Available
1-PhthalazinylhydrazineNot AvailableNot Available
6-HydralazineNot AvailableNot Available
HidralazinaNot AvailableNot Available
HydralazinNot AvailableNot Available
HydralazinumNot AvailableNot Available
HydrallazineNot AvailableNot Available
HydrazinophthalazineNot AvailableNot Available
Hydrazone 1(2H)-phthalazinoneNot AvailableNot Available
HypophthalinNot AvailableNot Available
IdralazinaNot AvailableNot Available
Phthalazin-1-ylhydrazineNot AvailableNot Available
Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Apresolinesolution20 mgintravenousSterimax IncNot AvailableNot AvailableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Generic Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Hydralazine Hydrochloridetablet10 mgoralMylan Pharmaceuticals Inc.2010-12-13Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Hydralazine Hydrochloridetablet25 mgoralMylan Pharmaceuticals Inc.2010-12-13Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Hydralazine Hydrochloridetablet50 mgoralMylan Pharmaceuticals Inc.2010-12-13Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Hydralazine Hydrochloridetablet100 mgoralMylan Pharmaceuticals Inc.2010-12-13Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Hydralazine Hydrochlorideinjection, solution20 mg/mLintramuscular; intravenousAmerican Regent, Inc.1997-06-30Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Hydralazine Hydrochloridetablet10 mgoralNcs Health Care Of Ky, Inc Dba Vangard Labs1982-10-05Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Hydralazine Hydrochloridetablet25 mgoralNcs Health Care Of Ky, Inc Dba Vangard Labs1980-02-27Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Hydralazine Hydrochloridetablet50 mgoralNcs Health Care Of Ky, Inc Dba Vangard Labs1980-02-27Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Hydralazine Hydrochloridetablet100 mgoralNcs Health Care Of Ky, Inc Dba Vangard Labs1983-09-27Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Hydralazine Hydrochlorideinjection20 mg/mLintramuscular; intravenousAkorn, Inc.2013-02-21Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Hydralazine Hydrochlorideinjection20 mg/mLintramuscular; intravenousAkorn, Inc.2009-05-01Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Hydralazine Hydrochloridetablet10 mgoralRebel Distributors Corp2008-09-12Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Hydralazine Hydrochloridetablet25 mgoralRebel Distributors Corp2008-09-12Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Hydralazine Hydrochloridetablet50 mgoralRebel Distributors Corp2008-09-12Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Hydralazine Hydrochloridetablet100 mgoralRebel Distributors Corp2008-09-12Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Hydralazine Hydrochloridetablet, film coated10 mgoralHeritage Pharmaceuticals Inc2007-04-06Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Hydralazine Hydrochloridetablet, film coated25 mgoralHeritage Pharmaceuticals Inc2007-04-06Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Hydralazine Hydrochloridetablet, film coated50 mgoralHeritage Pharmaceuticals Inc2007-04-06Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Hydralazine Hydrochloridetablet, film coated100 mgoralHeritage Pharmaceuticals Inc2007-04-06Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Hydralazine Hydrochloridetablet10 mgoralREMEDYREPACK INC.2013-03-18Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Hydralazine Hydrochloridetablet10 mgoralCamber Pharmaceuticals2010-01-01Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Hydralazine Hydrochloridetablet25 mgoralCamber Pharmaceuticals2010-01-01Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Hydralazine Hydrochloridetablet50 mgoralCamber Pharmaceuticals2010-01-01Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Hydralazine Hydrochloridetablet100 mgoralCamber Pharmaceuticals2010-01-01Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Hydralazine Hydrochloridetablet50 mgoralLake Erie Medical DBA Quality Care Products LLC2010-01-01Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Hydralazine Hydrochloridetablet25 mgoralLake Erie Medical DBA Quality Care Products LLC2009-06-01Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Hydralazine Hydrochloridetablet10 mgoralLake Erie Medical DBA Quality Care Products LLC2009-06-01Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Hydralazine Hydrochloridetablet, film coated50 mgoralPd Rx Pharmaceuticals, Inc.2007-04-06Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Hydralazine Hydrochloridetablet, film coated50 mgoralAphena Pharma Solutions Tennessee, Llc2007-04-06Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Hydralazine Hydrochloridetablet, film coated25 mgoralAphena Pharma Solutions Tennessee, Llc2007-04-06Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Hydralazine Hydrochloridetablet, film coated100 mgoralAphena Pharma Solutions Tennessee, Llc2007-04-06Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Hydralazine Hydrochloridetablet, film coated25 mgoralSafecor Health, LLC2014-09-30Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Hydralazine Hydrochloridetablet25 mgoralREMEDYREPACK INC.2010-11-18Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Hydralazine Hydrochloridetablet, film coated25 mgoralREMEDYREPACK INC.2011-04-19Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Hydralazine Hydrochloridetablet, film coated25 mgoralREMEDYREPACK INC.2011-04-28Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Hydralazine Hydrochloridetablet50 mgoralREMEDYREPACK INC.2011-12-09Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Hydralazine Hydrochloridetablet10 mgoralREMEDYREPACK INC.2011-11-17Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Hydralazine Hydrochloridetablet25 mgoralPar Pharmaceutical, Inc.1980-02-27Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Hydralazine Hydrochloridetablet50 mgoralPar Pharmaceutical, Inc.1980-02-27Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Hydralazine Hydrochloridetablet10 mgoralPar Pharmaceutical, Inc.1982-10-05Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Hydralazine Hydrochloridetablet100 mgoralPar Pharmaceutical, Inc.1983-09-27Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Hydralazine Hydrochloridetablet25 mgoralA S Medication Solutions Llc2010-01-01Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Hydralazine Hydrochloridetablet25 mgoralA S Medication Solutions Llc2009-06-01Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Hydralazine Hydrochloridetablet50 mgoralA S Medication Solutions Llc2010-01-01Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Hydralazine Hydrochloridetablet25 mgoralPliva Inc.1990-09-30Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Hydralazine Hydrochloridetablet50 mgoralPliva Inc.1990-09-30Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Hydralazine Hydrochloridetablet100 mgoralPliva Inc.1990-09-30Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Hydralazine Hydrochloridetablet10 mgoralPliva Inc.1990-09-30Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Hydralazine Hydrochloridetablet, film coated10 mgoralUnit Dose Services2007-04-06Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Hydralazine Hydrochloridetablet, film coated25 mgoralUnit Dose Services2007-04-06Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Hydralazine Hydrochloridetablet, film coated50 mgoralUnit Dose Services2007-04-06Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Hydralazine Hydrochloridetablet10 mgoralMylan Institutional Inc.2007-12-26Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Hydralazine Hydrochloridetablet25 mgoralMylan Institutional Inc.2007-12-26Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Hydralazine Hydrochloridetablet50 mgoralMylan Institutional Inc.2007-12-26Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Hydralazine Hydrochloridetablet10 mgoralREMEDYREPACK INC.2013-05-02Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Hydralazine Hydrochloridetablet25 mgoralREMEDYREPACK INC.2013-06-03Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Hydralazine Hydrochloridetablet50 mgoralREMEDYREPACK INC.2013-05-28Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Hydralazine Hydrochloridetablet50 mgoralREMEDYREPACK INC.2013-07-01Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Hydralazine Hydrochloridetablet25 mgoralREMEDYREPACK INC.2013-05-13Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Hydralazine Hydrochloridetablet50 mgoralREMEDYREPACK INC.2014-06-11Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Hydralazine Hydrochloridetablet100 mgoralREMEDYREPACK INC.2014-06-11Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Hydralazine Hydrochloridetablet10 mgoralREMEDYREPACK INC.2014-07-09Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Hydralazine Hydrochlorideinjection, solution20 mg/mLintramuscular; intravascularGeneral Injectables & Vaccines, Inc2011-10-19Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Hydralazine Hydrochlorideinjection, solution20 mg/mLintramuscular; intravenousGeneral Injectables & Vaccines, Inc2010-08-01Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Hydralazine Hydrochloridetablet, film coated50 mgoralAidarex Pharmaceuticals LLC2007-04-06Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Hydralazine Hydrochloridetablet50 mgoralState of Florida DOH Central Pharmacy2013-01-01Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Hydralazine Hydrochloridetablet50 mgoralState of Florida DOH Central Pharmacy2014-11-01Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Hydralazine Hydrochloridetablet25 mgoralA S Medication Solutions Llc2010-01-01Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Hydralazine Hydrochloridetablet50 mgoralA S Medication Solutions Llc2010-01-01Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Hydralazine Hydrochloridetablet, film coated100 mgoralPhysicians Total Care, Inc.2007-04-10Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Hydralazine Hydrochloridetablet, film coated25 mgoralPhysicians Total Care, Inc.2007-09-17Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Hydralazine Hydrochloridetablet, film coated50 mgoralPhysicians Total Care, Inc.2007-09-17Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Hydralazine Hydrochloridetablet, film coated10 mgoralPhysicians Total Care, Inc.2007-07-13Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Hydralazine Hydrochlorideinjection, solution20 mg/mLintramuscular; intravenousPhysicians Total Care, Inc.2011-05-17Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Hydralazine Hydrochlorideinjection20 mg/mLintramuscular; intravenousCardinal Health2009-05-01Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Hydralazine Hydrochlorideinjection20 mg/mLintramuscular; intravenousCardinal Health2009-05-01Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Hydralazinetablet50 mgoralCardinal Health2009-09-14Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Hydralazinetablet25 mgoralCardinal Health2009-09-14Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Hydralazine Hydrochloridetablet25 mgoralCardinal Health2008-03-18Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Hydralazine Hydrochloridetablet50 mgoralCardinal Health2008-03-18Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Hydralazine Hydrochloridetablet, film coated10 mgoralCardinal Health2007-04-06Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Hydralazine Hydrochloridetablet, film coated100 mgoralCardinal Health2007-04-06Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Hydralazine Hydrochloridetablet, film coated10 mgoralCardinal Health2007-04-06Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Hydralazine Hydrochloridetablet50 mgoralCardinal Health2011-05-13Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Hydralazine Hydrochloridetablet10 mgoralCardinal Health2011-05-13Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Hydralazine Hydrochloridetablet25 mgoralCardinal Health2011-05-13Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Hydralazine Hydrochlorideinjection, solution20 mg/mLintramuscular; intravenousCardinal Health1997-06-30Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Hydralazine Hydrochloridetablet25 mgoralCardinal Health2009-12-07Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Hydralazine Hydrochloridetablet10 mgoralCardinal Health2009-12-07Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Hydralazine Hydrochloridetablet10 mgoralCardinal Health2010-09-10Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Hydralazine Hydrochlorideinjection20 mg/mLintramuscular; intravenousCardinal Health2011-01-31Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Hydralazine Hydrochlorideinjection20 mg/mLintramuscular; intravenousCardinal Health2011-01-31Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Hydralazine Hydrochloridetablet10 mgoralClinical Solutions Wholesale2009-06-01Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Hydralazine Hydrochloridetablet25 mgoralClinical Solutions Wholesale2009-06-01Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Hydralazine Hydrochloridetablet50 mgoralClinical Solutions Wholesale2009-06-01Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Hydralazine Hydrochloridetablet100 mgoralClinical Solutions Wholesale2009-06-01Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Hydralazine Hydrochloridetablet25 mgoralStrides Pharma Inc2013-05-04Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Hydralazine Hydrochloridetablet50 mgoralStrides Pharma Inc2013-05-04Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Hydralazine Hydrochloridetablet100 mgoralStrides Pharma Inc2013-05-04Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Hydralazine Hydrochloridetablet10 mgoralGolden State Medical Supply, Inc.2008-12-15Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Hydralazine Hydrochloridetablet25 mgoralGolden State Medical Supply, Inc.2008-12-15Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Hydralazine Hydrochloridetablet50 mgoralGolden State Medical Supply, Inc.2008-12-15Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Hydralazine Hydrochloridetablet100 mgoralGolden State Medical Supply, Inc.2008-12-15Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Hydralazine Hydrochloridetablet, film coated10 mgoralSt Marys Medical Park Pharmacy2014-04-21Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Hydralazine Hydrochloridetablet, film coated50 mgoralSt Marys Medical Park Pharmacy2014-04-21Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Hydralazine Hydrochloridetablet, film coated25 mgoralSt Marys Medical Park Pharmacy2014-04-21Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Hydralazine Hydrochloridetablet50 mgoralREMEDYREPACK INC.2014-09-12Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Hydralazine Hydrochloridetablet25 mgoralREMEDYREPACK INC.2014-10-24Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Hydralazine Hydrochloridetablet25 mgoralREMEDYREPACK INC.2014-12-18Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Hydralazine Hydrochloridetablet25 mgoralAmerican Health Packaging2008-03-18Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Hydralazine Hydrochloridetablet50 mgoralAmerican Health Packaging2008-03-18Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Hydralazine Hydrochlorideinjection20 mg/mLintramuscular; intravenousFresenius Kabi USA, LLC2001-09-05Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Hydralazine Hydrochlorideinjection20 mg/mLintramuscular; intravenousFresenius Kabi USA, LLC2011-01-31Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Hydralazine Hydrochloridetablet50 mgoralbryant ranch prepack2010-01-01Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Hydralazine Hydrochloridetablet10 mgoralbryant ranch prepack2010-01-01Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Hydralazine Hydrochloridetablet25 mgoralMc Kesson Packaging Services A Business Unit Of Mc Kesson Corporation1990-09-30Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Hydralazine Hydrochloridetablet50 mgoralMc Kesson Packaging Services A Business Unit Of Mc Kesson Corporation1990-09-30Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Hydralazine Hydrochloridetablet25 mgoralStrides Arcolab Limited2013-06-30Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Hydralazine Hydrochloridetablet50 mgoralStrides Arcolab Limited2013-06-30Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Hydralazine Hydrochloridetablet100 mgoralStrides Arcolab Limited2013-06-30Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Hydralazine Hydrochloridetablet25 mgoralCadila Pharmaceuticals Limited2014-09-24Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Hydralazine Hydrochloridetablet50 mgoralCadila Pharmaceuticals Limited2014-09-24Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Hydralazine Hydrochloridetablet100 mgoralCadila Pharmaceuticals Limited2014-09-24Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Hydralazine Hydrochloridetablet100 mgoralAscend Laboratories, LLC2010-05-24Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Hydralazine Hydrochloridetablet50 mgoralAscend Laboratories, LLC2009-11-24Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Hydralazine Hydrochloridetablet25 mgoralAscend Laboratories, LLC2010-05-24Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Hydralazine Hydrochloridetablet10 mgoralAscend Laboratories, LLC2010-05-24Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Hydralazine Hydrochloridetablet10 mgoralAmerican Health Packaging2010-09-10Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Hydralazine Hydrochloridetablet100 mgoralAmerican Health Packaging2011-09-19Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Hydralazine Hydrochloridetablet10 mgoralGlenmark Generics Inc., USA2009-06-01Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Hydralazine Hydrochloridetablet25 mgoralGlenmark Generics Inc., USA2009-06-01Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Hydralazine Hydrochloridetablet50 mgoralGlenmark Generics Inc., USA2009-06-01Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Hydralazine Hydrochloridetablet100 mgoralGlenmark Generics Inc., USA2009-06-01Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Hydralazine Hydrochloridetablet10 mgoralMc Kesson Contract Packaging2011-12-02Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Hydralazine Hydrochloridetablet25 mgoralMc Kesson Contract Packaging2011-10-25Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Hydralazine Hydrochloridetablet50 mgoralMc Kesson Contract Packaging2011-10-25Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Hydralazinetablet10 mgoralAa Pharma IncNot AvailableNot AvailableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Hydralazinetablet25 mgoralAa Pharma IncNot AvailableNot AvailableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Hydralazinetablet50 mgoralAa Pharma IncNot AvailableNot AvailableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Over the Counter ProductsNot Available
International Brands
NameCompany
AlphapressAlphapharm
AprezinJohnson
Cesoline WPharmasant
Cesoline YPharmasant
DiazideThe Central
HidralBiocontrol
PressfallNisshin Seiyaku
SerpathiazideWashington
Brand mixtures
Brand NameIngredients
BiDilisosorbide dinitrate + hydralazine hydrochloride
Salts
Name/CASStructureProperties
Hydralazine hydrochloride
Thumb
  • InChI Key: ZUXNZUWOTSUBMN-UHFFFAOYSA-N
  • Monoisotopic Mass: 196.051574015
  • Average Mass: 196.637
DBSALT000792
CategoriesNot Available
CAS number86-54-4
WeightAverage: 160.1759
Monoisotopic: 160.074896276
Chemical FormulaC8H8N4
InChI KeyRPTUSVTUFVMDQK-UHFFFAOYSA-N
InChI
InChI=1S/C8H8N4/c9-11-8-7-4-2-1-3-6(7)5-10-12-8/h1-5H,9H2,(H,11,12)
IUPAC Name
1-hydrazinylphthalazine
SMILES
NNC1=NN=CC2=CC=CC=C12
Taxonomy
DescriptionThis compound belongs to the class of organic compounds known as phthalazines. These are compounds containing a phthalazine moiety, which consists of a benzene ring fused to a pyridazine, forming a 2,3-benzodiazine skeleton.
KingdomOrganic compounds
Super ClassOrganoheterocyclic compounds
ClassNaphthyridines
Sub ClassPhthalazines
Direct ParentPhthalazines
Alternative Parents
Substituents
  • Phthalazine
  • Aminopyridazine
  • Imidolactam
  • Benzenoid
  • Pyridazine
  • Heteroaromatic compound
  • Azacycle
  • Hydrocarbon derivative
  • Organonitrogen compound
  • Hydrazine derivative
  • Aromatic heteropolycyclic compound
Molecular FrameworkAromatic heteropolycyclic compounds
External Descriptors
Pharmacology
IndicationFor the treatment of essential hypertension, alone or as an adjunct. Also for the management of severe hypertension when the drug cannot be given orally or when blood pressure must be lowered immediately, congestive heart failure (in combination with cardiac glycosides and diuretics and/or with isosorbide dinitrate), and hypertension secondary to pre-eclampsia/eclampsia.
PharmacodynamicsA vasodilator, hydralazine works by relaxing blood vessels (arterioles more than venules) and increasing the supply of blood and oxygen to the heart while reducing its workload. It also functions as an antioxidant. It inhibits membrane-bound enzymes that form reactive oxygen species, such as superoxides. Excessive superoxide counteracts NO-induced vasodilation. It is commonly used in the condition of pregnancy called preeclampsia.
Mechanism of actionAlthough the precise mechanism of action of hydralazine is not fully understood, the major effects are on the cardiovascular system. Hydralazine apparently lowers blood pressure by exerting a peripheral vasodilating effect through a direct relaxation of vascular smooth muscle. It has also been suggested that cyclic 3',5'-adenosine monophosphate (cyclic AMP) mediates, at least partly, the relaxation of arterial smooth muscle by altering cellular calcium metabolism, which interferes with the calcium movements within the vascular smooth muscle that are responsible for initiating or maintaining the contractile state. In hypertensive patients, the hydralazine-induced decrease in blood pressure is accompanied by increased heart rate, cardiac output, and stroke volume, probably because of a reflex response to decreased peripheral resistance. The drug has no direct effect on the heart. Hydralazine may increase pulmonary arterial pressure, as well as coronary, splanchnic, cerebral, and renal blood flow. The preferential dilatation of arterioles, as compared to veins, minimizes postural hypotension and promotes the increase in cardiac output. Hydralazine usually increases renin activity in plasma, presumably as a result of increased secretion of renin by the renal juxtaglomerular cells in response to reflex sympathetic discharge. This increase in renin activity leads to the production of angiotensin II, which then causes stimulation of aldosterone and consequent sodium reabsorption. Tolerance to the antihypertensive effect of the drug develops during prolonged therapy, especially if a diuretic is not administered concurrently. In patients with CHF, hydralazine decreases systemic vascular resistance and increases cardiac output.
AbsorptionHydralazine is rapidly and extensively absorbed (up to 90%) from the gastrointestinal tract and undergoes extensive first-pass metabolism by genetic polymorphic acetylation. Oral bioavailability of hydralazine is dependent upon acetylator phenotype. Bioavailability is approximately 31% in slow acetylators and 10% in fast acetylators.
Volume of distributionNot Available
Protein binding87%
Metabolism

Hydralazine, when administered orally, undergoes extensive first-pass metabolism by genetic polymorphic acetylation, which is responsible for a threefold range of oral bioavailability. Intravenously administered hydralazine does not undergo first-pass metabolism and, therefore, is not affected by acetylator phenotype. After the drug reaches the systemic circulation, it is combined with endogenous aldehydes and ketones, including pyruvic acid, to form hydrazone metabolites. The active metabolites, hydralazine acetonide hydrazone and hydralazine pyruvate hydrazone, are equipotent with the parent, hydralazine.

SubstrateEnzymesProduct
Hydralazine
Not Available
Hydralazine acetone hydrazoneDetails
Hydralazine
Not Available
Hydralazine pyruvate hydrazoneDetails
Route of eliminationHydralazine undergoes extensive hepatic metabolism; it is excreted mainly in the form of metabolites in the urine.
Half life3 to 7 hours
ClearanceNot Available
ToxicityOral LD50 in rats: 173 and 187 mg/kg
Affected organisms
  • Humans and other mammals
PathwaysNot Available
SNP Mediated EffectsNot Available
SNP Mediated Adverse Drug ReactionsNot Available
ADMET
Predicted ADMET features
PropertyValueProbability
Human Intestinal Absorption+0.9854
Blood Brain Barrier+0.9487
Caco-2 permeable+0.8867
P-glycoprotein substrateNon-substrate0.686
P-glycoprotein inhibitor INon-inhibitor0.9478
P-glycoprotein inhibitor IINon-inhibitor0.9826
Renal organic cation transporterNon-inhibitor0.8279
CYP450 2C9 substrateNon-substrate0.8971
CYP450 2D6 substrateNon-substrate0.9116
CYP450 3A4 substrateNon-substrate0.7467
CYP450 1A2 substrateInhibitor0.9106
CYP450 2C9 substrateNon-inhibitor0.9071
CYP450 2D6 substrateNon-inhibitor0.9231
CYP450 2C19 substrateNon-inhibitor0.9025
CYP450 3A4 substrateInhibitor0.526
CYP450 inhibitory promiscuityLow CYP Inhibitory Promiscuity0.5294
Ames testAMES toxic0.9107
CarcinogenicityNon-carcinogens0.7719
BiodegradationNot ready biodegradable1.0
Rat acute toxicity3.2187 LD50, mol/kg Not applicable
hERG inhibition (predictor I)Weak inhibitor0.9253
hERG inhibition (predictor II)Non-inhibitor0.8589
Pharmacoeconomics
ManufacturersNot Available
Packagers
Dosage forms
FormRouteStrength
Injectionintramuscular; intravenous20 mg/mL
Injection, solutionintramuscular; intravascular20 mg/mL
Injection, solutionintramuscular; intravenous20 mg/mL
Solutionintravenous20 mg
Tabletoral10 mg
Tabletoral100 mg
Tabletoral25 mg
Tabletoral50 mg
Tablet, film coatedoral10 mg
Tablet, film coatedoral100 mg
Tablet, film coatedoral25 mg
Tablet, film coatedoral50 mg
Prices
Unit descriptionCostUnit
Hydralazine 20 mg/ml vial18.0USD ml
Hydralazine 100 mg tablet1.65USD tablet
Hydralazine-HCTZ 50-50 mg capsule1.2USD capsule
HydrALAZINE HCl 100 mg tablet1.05USD tablet
Hydralazine-HCTZ 25-25 mg capsule0.81USD capsule
Hydralazine-HCTZ 100-50 mg capsule0.75USD capsule
HydrALAZINE HCl 50 mg tablet0.67USD tablet
Apresoline 50 mg tablet0.65USD tablet
HydrALAZINE HCl 25 mg tablet0.53USD tablet
HydrALAZINE HCl 10 mg tablet0.47USD tablet
Hydralazine 50 mg tablet0.44USD tablet
Hydralazine 25 mg tablet0.35USD tablet
Apo-Hydralazine 50 mg Tablet0.29USD tablet
Novo-Hylazin 50 mg Tablet0.29USD tablet
Apo-Hydralazine 25 mg Tablet0.24USD tablet
Hydralazine 10 mg tablet0.22USD tablet
Apo-Hydralazine 10 mg Tablet0.11USD tablet
Novo-Hylazin 10 mg Tablet0.11USD tablet
DrugBank does not sell nor buy drugs. Pricing information is supplied for informational purposes only.
PatentsNot Available
Properties
StateSolid
Experimental Properties
PropertyValueSource
melting point172-173 °CU.S. Patent 2,484,029.
logP1.00SANGSTER (1993)
Predicted Properties
PropertyValueSource
Water Solubility2.61 mg/mLALOGPS
logP0.66ALOGPS
logP0.75ChemAxon
logS-1.8ALOGPS
pKa (Strongest Acidic)17.69ChemAxon
pKa (Strongest Basic)6.4ChemAxon
Physiological Charge0ChemAxon
Hydrogen Acceptor Count4ChemAxon
Hydrogen Donor Count2ChemAxon
Polar Surface Area63.83 Å2ChemAxon
Rotatable Bond Count1ChemAxon
Refractivity50.23 m3·mol-1ChemAxon
Polarizability16.06 Å3ChemAxon
Number of Rings2ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleYesChemAxon
Spectra
Mass Spec (NIST)Not Available
SpectraNot Available
References
Synthesis Reference

U.S. Patent 2,484,029.

General Reference
  1. Kandler MR, Mah GT, Tejani AM, Stabler SN: Hydralazine for essential hypertension. Cochrane Database Syst Rev. 2010 Aug 4;8:CD004934. Pubmed
External Links
ATC CodesC02DB02
AHFS Codes
  • 24:08.20
PDB EntriesNot Available
FDA labelNot Available
MSDSDownload (73.7 KB)
Interactions
Drug Interactions
Drug
MetoprololIncreased effect of both drugs
PropranololIncreased effect of both drugs
TreprostinilAdditive hypotensive effect. Monitor antihypertensive therapy during concomitant use.
Food InteractionsNot Available

Targets

1. Membrane primary amine oxidase

Kind: protein

Organism: Human

Pharmacological action: yes

Actions: inhibitor

Components

Name UniProt ID Details
Membrane primary amine oxidase Q16853 Details

References:

  1. Claud P, Padovani P, Guichard JP, Artur Y, Laine R: Involvement of semicarbazide-sensitive amine oxidase in tresperimus metabolism in human and in rat. Drug Metab Dispos. 2001 May;29(5):735-41. Pubmed
  2. Vidrio H, Medina M, Gonzalez-Romo P, Lorenzana-Jimenez M, Diaz-Arista P, Baeza A: Semicarbazide-sensitive amine oxidase substrates potentiate hydralazine hypotension: possible role of hydrogen peroxide. J Pharmacol Exp Ther. 2003 Nov;307(2):497-504. Epub 2003 Sep 11. Pubmed
  3. Vidrio H: Semicarbazide-sensitive amine oxidase: role in the vasculature and vasodilation after in situ inhibition. Auton Autacoid Pharmacol. 2003 Oct-Dec;23(5-6):275-83. Pubmed
  4. Vidrio H, Medina M: 2-bromoethylamine, a suicide inhibitor of semicarbazide-sensitive amine oxidase, increases hydralazine hypotension in rats. J Cardiovasc Pharmacol. 2005 Sep;46(3):316-24. Pubmed
  5. Vidrio H, Medina M: Hypotensive effect of hydroxylamine, an endogenous nitric oxide donor and SSAO inhibitor. J Neural Transm. 2007;114(6):863-5. Epub 2007 Mar 26. Pubmed
  6. Gronvall JL, Garpenstrand H, Oreland L, Ekblom J: An autoradiographic method of visualising semicarbazide-sensitive amine oxidase activity in mouse tissue sections. Neurobiology (Bp). 2000;8(2):167-77. Pubmed
  7. Gronvall JL, Garpenstrand H, Oreland L, Ekblom J: Autoradiographic imaging of formaldehyde adducts in mice: possible relevance for vascular damage in diabetes. Life Sci. 1998;63(9):759-68. Pubmed
  8. Lizcano JM, Fernandez de Arriba A, Tipton KF, Unzeta M: Inhibition of bovine lung semicarbazide-sensitive amine oxidase (SSAO) by some hydrazine derivatives. Biochem Pharmacol. 1996 Jul 26;52(2):187-95. Pubmed
  9. Lyles GA, McDougall SA: The enhanced daily excretion of urinary methylamine in rats treated with semicarbazide or hydralazine may be related to the inhibition of semicarbazide-sensitive amine oxidase activities. J Pharm Pharmacol. 1989 Feb;41(2):97-100. Pubmed
  10. Barrand MA, Callingham BA: The interaction of hydralazine with a semicarbazide-sensitive amine oxidase in brown adipose tissue of the rat. Its use as a radioactive ligand for the enzyme. Biochem J. 1985 Dec 1;232(2):415-23. Pubmed
  11. Barrand MA, Fox SA: Amine oxidase activities in brown adipose tissue of the rat: identification of semicarbazide-sensitive (clorgyline-resistant) activity at the fat cell membrane. J Pharm Pharmacol. 1984 Oct;36(10):652-8. Pubmed

2. Prolyl 4-hydroxylase subunit alpha-1

Kind: protein

Organism: Human

Pharmacological action: unknown

Actions: inhibitor

Components

Name UniProt ID Details
Prolyl 4-hydroxylase subunit alpha-1 P13674 Details

References:

  1. Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. Pubmed
  2. Knowles HJ, Tian YM, Mole DR, Harris AL: Novel mechanism of action for hydralazine: induction of hypoxia-inducible factor-1alpha, vascular endothelial growth factor, and angiogenesis by inhibition of prolyl hydroxylases. Circ Res. 2004 Jul 23;95(2):162-9. Epub 2004 Jun 10. Pubmed
  3. Murad S, Tajima S, Pinnell SR: A paradoxical effect of hydralazine on prolyl and lysyl hydroxylase activities in cultured human skin fibroblasts. Arch Biochem Biophys. 1985 Sep;241(2):356-63. Pubmed# Chen KH, Paz MA, Gallop PM: Collagen prolyl hydroxylation in WI-
    38 fibroblast cultures: action of hydralazine. In Vitro. 1977 Jan;13(1):49-54. Pubmed

Enzymes

1. Cytochrome P450 3A4

Kind: protein

Organism: Human

Pharmacological action: unknown

Actions: inhibitor

Components

Name UniProt ID Details
Cytochrome P450 3A4 P08684 Details

References:

  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. Pubmed
  2. Zhao XJ, Ishizaki T: Metabolic interactions of selected antimalarial and non-antimalarial drugs with the major pathway (3-hydroxylation) of quinine in human liver microsomes. Br J Clin Pharmacol. 1997 Nov;44(5):505-11. Pubmed

Comments
comments powered by Disqus
Drug created on May 16, 2007 14:38 / Updated on April 28, 2014 17:56