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Identification
NameBismuth Subsalicylate
Accession NumberDB01294  (DB01402)
TypeSmall Molecule
GroupsApproved, Vet Approved
Description

Bismuth subsalicylate is the active ingredient in the popular medication Pepto-Bismol that is used to treat nausea, heartburn, indigestion, upset stomach, diarrhea, and other temporary discomforts of the stomach and gastrointestinal tract. It is also the main ingredient of Kaopectate. It displays anti-inflammatory action (due to salicylic acid) and also acts as an antacid and mild antibiotic.

Structure
Thumb
Synonyms
2-Hydroxy-benzo[1,3,2]dioxabismin-4-one
Basic bismuth salicylate
Bismuth oxide salicylate
Bismuth oxysalicylate
Bismuth subsalicylate
pink bismuth
Wismutsubsalicylat
External Identifiers Not Available
Approved Prescription ProductsNot Available
Approved Generic Prescription ProductsNot Available
Approved Over the Counter Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
7 Select Pink Bismuthsuspension1050 mg/30mLoral7 Eleven2014-04-17Not applicableUs
7-select Pepto Bismoltablet, chewable262 mg/1oralLil' Drug Store Products, Inc2011-08-01Not applicableUs
Being Well Stomach Relief Original Strengthsuspension525 mg/30mLoralSave A Lot Food Stores Ltd2006-02-25Not applicableUs
Bismatrolliquid262 mg/15mLoralMajor Pharmaceuticals2008-05-30Not applicableUs
Bismatrolliquid262 mg/15mLoralProficient Rx LP2008-05-30Not applicableUs
Bismatrolliquid262 mg/15mLoralAidarex Pharmaceuticals LLC2008-05-30Not applicableUs
Bismatroltablet, chewable262 mg/1oralProficient Rx LP2003-01-03Not applicableUs
Bismatroltablet, chewable262 mg/1oralAidarex Pharmaceuticals LLC2003-01-03Not applicableUs
Bismatroltablet, chewable262 mg/1oralMajor Pharmaceuticals2003-01-03Not applicableUs
Bismatrolliquid525 mg/15mLoralMajor Pharmaceuticals2009-01-05Not applicableUs
Bismatrolliquid262 mg/15mLoralAtlantic Biologicals Corps2008-05-30Not applicableUs
Bismed Liq 17.66mg/mlliquid17.66 mgoralTechnilab Pharma Inc.1994-12-312005-08-05Canada
Bismoltablet262 mg/434mgoralSAMSUNG PHARM IND. CO., LTD.2013-02-01Not applicableUs
Bismuthtablet262 mgoralPharmetics (2011) Inc2009-02-04Not applicableCanada
Bismuthliquid17.6 mgoralPerrigo International1998-04-08Not applicableCanada
Bismuthliquid262 mg/15mLoralRij Pharmaceutical Corporation1999-03-16Not applicableUs
Bismuthtablet262 mg/1oralAllegiant Health2014-12-23Not applicableUs
Bismuthtablet262 mgoralPharmalab Inc.Not applicableNot applicableCanada
Bismuthsuspension17.5 mgoralActavis Pharma CompanyNot applicableNot applicableCanada
Bismuth (cherry Flavour)liquid17.5 mgoralArrow Otc Company2008-01-022012-07-24Canada
Bismuth (original Formula)liquid17.5 mgoralArrow Otc Company2008-01-022011-08-03Canada
Bismuth Capletstablet262 mgoralActavis Pharma Company2014-08-25Not applicableCanada
Bismuth Capletstablet262 mgoralJamp Pharma Corporation2004-06-26Not applicableCanada
Bismuth Capletstablet262 mgoralVita Health Products Inc2001-04-012002-07-31Canada
Bismuth Capletstablet262 mgoralTanta Pharmaceuticals IncNot applicableNot applicableCanada
Bismuth Chewablestablet (chewable)262 mgoralActavis Pharma Company2014-09-09Not applicableCanada
Bismuth Chewablestablet262 mgoralJamp Pharma Corporation2003-10-16Not applicableCanada
Bismuth Liq 17.6mg/mlliquid17.6 mgoralTechnilab Pharma Inc.1990-12-311997-08-22Canada
Bismuth Liquidliquid17.6 mgoralTanta Pharmaceuticals IncNot applicableNot applicableCanada
Bismuth Liquidliquid17.6 mgoralSupplements Aromatik Inc.Not applicableNot applicableCanada
Bismuth Subsalicylatetablet262 mg/1oralRugby Laboratories Inc.1996-01-23Not applicableUs
Bismuth Subsalicylatetablet262 mgoralLil' Drug Store Products Inc2013-11-12Not applicableCanada
Bismuth Subsalicylate 262 mgtablet, chewable262 mg/1oralReliable 1 Laboratories Llc2015-11-01Not applicableUs
Bismuth Subsalicylate Capletstablet262 mgoralGuardian Drug Company Inc2010-02-01Not applicableCanada
Bismuth Subsalicylate Liquidliquid17.5 mgoralGuardian Drug Company Inc2008-12-12Not applicableCanada
Bismuth Subsalicylate Liquidliquid17.6 mgoralPharmetics (2011) IncNot applicableNot applicableCanada
Bismuth Subsalicylate Liquid Extra Strengthsuspension35.2 mgoralCrlsNot applicableNot applicableCanada
Bismuth Subsalicylate Liquid Extra Strengthsuspension35.2 mgoralPharmetics (2011) IncNot applicableNot applicableCanada
Bismuth Subsalicylate Maximum Strength Stomach Reliefliquid1050 mg/30mLoralAurohealth LLC2015-12-29Not applicableUs
Bismuth Subsalicylate Suspension 17.6mg/mlsuspension17.6 mgoralStanley Pharmaceuticals, A Division Of Vita Health Products Inc.1992-12-312002-07-31Canada
Bismuth Subsalicylate Suspension 17.6mg/mlsuspension17.6 mgoralWes Pak Products Ltd.1995-12-312000-08-04Canada
Bismuth Tabstablet, chewable262 mg/1oralDolgencorp, LLC1998-07-16Not applicableUs
Bismutinaliquid262 mg/15mLoralMenper Distributors, Inc.2012-02-21Not applicableUs
Bismylate-bismuth Subsalicylate Sus 17.6gm/mlsuspension17.6 mgoralStanley Pharmaceuticals, A Division Of Vita Health Products Inc.1990-12-312002-07-31Canada
Careone Stomach Reliefsuspension1050 mg/30mLoralAmerican Sales Company2012-08-05Not applicableUs
Careone Stomach Reliefsuspension525 mg/30mLoralAmerican Sales Company2012-08-05Not applicableUs
Chewabletablet, chewable262 mg/1oralPublix Super Markets Inc2001-03-15Not applicableUs
Circle K Stomachliquid525 mg/30mLoralLil' Drug Store Products, Inc2014-11-01Not applicableUs
Desempacho Cucharadasliquid262 mg/15mLoralPharmalab Enterprises Inc.2009-01-09Not applicableUs
Dg Health Stomach Relief Maximum Strengthsuspension1050 mg/30mLoralDolgencorp Inc2012-09-09Not applicableUs
Equaline Stomach Reliefsuspension1050 mg/30mLoralSupervalu Inc2004-10-07Not applicableUs
Equaline Stomach Reliefliquid262 mg/15mLoralSupervalu Inc2004-10-14Not applicableUs
Equate Stomach Relief Maximum Strengthliquid1050 mg/30mLoralWal Mart Stores Inc2001-02-02Not applicableUs
Equate Stomach Relief Regular Strengthliquid262 mg/15mLoralWal Mart Stores Inc1989-12-15Not applicableUs
Estomaquil Polvopowder262 mg/1oralPro Mex Llc2004-01-02Not applicableUs
Estomaxliquid262 mg/15mLoralPharmadel LLC2012-02-21Not applicableUs
Extra Strength Bismuthsuspension35.2 mgoralActavis Pharma CompanyNot applicableNot applicableCanada
Extra Strength Bismuthliquid35 mgoralJamp Pharma Corporation2004-06-24Not applicableCanada
Extra Strength Bismuth Subsalicylate Liquidliquid35 mgoralGuardian Drug Company Inc2010-07-01Not applicableCanada
Extra-strength Bismuthsuspension35 mgoralPerrigo International2000-11-21Not applicableCanada
Family Care Stomach Reliefliquid1050 mg/30mLoralUNITED EXCHANGE CORP.2015-07-31Not applicableUs
Geri-pectate Peppermint Flavorliquid262 mg/15mLoralGeri Care Pharmaceuticals, Corp2000-01-01Not applicableUs
Geri-pectate Vanilla Flavorliquid262 mg/15mLoralGeri Care Pharmaceuticals, Corp2000-01-01Not applicableUs
Gnp Pink Bismuthtablet, chewable262 mg/1oralAmerisource Bergen2011-07-07Not applicableUs
Gnp Pink Bismuthtablet262 mg/1oralAmerisource Bergen2011-08-08Not applicableUs
Good Sense Stomach Relieftablet, chewable262 mg/1oralL Perrigo Company1993-08-24Not applicableUs
Good Sense Stomach Reliefliquid1050 mg/30mLoralL. Perrigo Company1990-01-15Not applicableUs
Good Sense Stomach Relief Original Strengthsuspension525 mg/30mLoralL. Perrigo Company1989-09-15Not applicableUs
Green Reliefliquid262 mg/15mLoralGreen Choice for Life2012-02-21Not applicableUs
Health Mart Stomach Relieftablet, chewable262 mg/1oralMc Kesson2012-04-01Not applicableUs
Health Mart Stomach Reliefsuspension525 mg/30mLoralMcKesson2016-03-26Not applicableUs
Healthy Accents Stomach Relieftablet, chewable262 mg/1oralDZA Brands LLC2012-01-02Not applicableUs
Healthy Accents Stomach Reliefliquid1050 mg/30mLoralDZA Brands LLC2008-01-22Not applicableUs
Healthy Accents Stomach Relief Original Strengthsuspension525 mg/30mLoralDZA Brands LLC2008-01-22Not applicableUs
Ka Pecliquid262 mg/15mLoralRij Pharmaceutical Corporation1999-03-16Not applicableUs
Kao-bisliquid262 mg/15mLoralRij Pharmaceutical Corporation1999-03-16Not applicableUs
Kao-tin Peppermint Flavorliquid262 mg/15mLoralMAJOR Pharmaceuticals Inc.2011-02-14Not applicableUs
Kaopectatetablet262 mg/1oralChattem, Inc.2013-04-01Not applicableUs
Kaopectate Extra Strength Peppermint Flavor Anti Diarrhealliquid35 mg/mLoralChattem, Inc.2003-04-01Not applicableUs
Kaopectate Regular Strength Cherry Flavorliquid262 mg/15mLoralChattem, Inc.2004-04-30Not applicableUs
Kaopectate Regular Strength Peppermint Flavor Anti Diarrhealliquid17.47 mg/mLoralChattem, Inc.2003-04-01Not applicableUs
Kaopectate Regular Strength Vanilla Flavor Anti Diarrhealliquid262 mg/15mLoralChattem, Inc.2003-04-01Not applicableUs
Kaopectate Regular Strength Vanilla Flavor Anti Diarrhealliquid262 mg/15mLoralPhysicians Total Care, Inc.2008-05-12Not applicableUs
Kola-pectin DSliquid525 mg/15mLoralSeyer Pharmatec, Inc.2007-10-01Not applicableUs
Leader Stomach Reliefliquid525 mg/15mLoralCardinal Health1994-11-09Not applicableUs
Leader Stomach Reliefliquid262 mg/15mLoralCardinal Health1990-04-15Not applicableUs
Leader Stomach Reliefsuspension1050 mg/30mLoralCardinal Health2014-02-20Not applicableUs
Leader Stomach Reliefsuspension525 mg/30mLoralCardinal Health1990-04-15Not applicableUs
Leader Stomach Relief Original Strengthtablet, chewable262 mg/1oralCardinal Health1997-10-07Not applicableUs
Maximum Strengthliquid525 mg/15mLoralPublix Super Markets Inc2002-08-08Not applicableUs
Maximum Strength Stomach Reliefliquid525 mg/15mLoralWin Co Foods, Llc2014-12-12Not applicableUs
Mcneil Stomach Reliefpiece (chewable)524 mgoralMcneil Consumer Healthcare Division Of Johnson & Johnson IncNot applicableNot applicableCanada
Medi-first Pep-T-medtablet, chewable262 mg/1oralUnifirst First Aid Corporation2011-12-01Not applicableUs
Medique Diotametablet, chewable262 mg/1oralUnifirst First Aid Corporation2008-12-30Not applicableUs
Medique Diotametablet, chewable262 mg/1oralUnifirst First Aid Corporation2014-04-01Not applicableUs
Medique Diotamesuspension262 mg/15mLoralUnique First Aid Corporation2011-04-05Not applicableUs
Moore Medical Bismuthtablet, chewable262 mg/1oralMoore Medical LLC2014-04-01Not applicableUs
Moore Medical Bismuthtablet, chewable262 mg/1oralMoore Medical LLC2008-12-30Not applicableUs
Original Formula Stomach Reliefliquid262 mg/15mLoralPublix Super Markets Inc1995-03-29Not applicableUs
Pepbis Regularsuspension17.5 mg/mLoralKc Pharmaceuticals, Inc.2004-03-04Not applicableUs
Pepsis Relieftablet262 mgoralViva Pharmaceutical Inc.Not applicableNot applicableCanada
Peptic Reliefsuspension262 mg/15mLoralBest Choice2009-02-03Not applicableUs
Peptic Reliefsuspension262 mg/15mLoralGood Neighbor Pharmacy2009-09-18Not applicableUs
Peptic Reliefsuspension262 mg/15mLoralBest Choice2009-01-16Not applicableUs
Peptic Reliefsuspension262 mg/15mLoralKinray, Inc2009-06-03Not applicableUs
Peptic Relieftablet262 mg/1oralRebel Distributors Corp2011-12-30Not applicableUs
Peptic Reliefsuspension262 mg/15mLoralAaron Industries, Inc.2010-01-08Not applicableUs
Peptic Reliefsuspension262 mg/15mLoralH.E.B2009-02-09Not applicableUs
Peptic Relieftablet262 mg/1oralRugby Laboratories2014-02-20Not applicableUs
Peptic Reliefliquid525 mg/30mLoralMarc Glassman, Inc.2015-02-28Not applicableUs
Peptic Reliefsuspension262 mg/15mLoralKroger2009-06-03Not applicableUs
Peptic Reliefsuspension525 mg/15mLoralRite Aid2009-09-23Not applicableUs
Peptic Reliefsuspension262 mg/15mLoralSelect Brand2009-06-03Not applicableUs
Peptic Reliefsuspension262 mg/15mLoralEqualine2009-03-20Not applicableUs
Peptic Reliefsuspension262 mg/15mLoralRite Aid2009-06-03Not applicableUs
Peptic Reliefsuspension262 mg/15mLoralChain Drug Consortium, LLC2009-08-13Not applicableUs
Peptic Relieftablet, chewable262 mg/1oralL&R Distributors, Inc.1998-07-16Not applicableUs
Peptic Reliefsuspension262 mg/15mLoralKroger2009-02-23Not applicableUs
Peptic Reliefsuspension262 mg/15mLoralLeader2009-04-02Not applicableUs
Peptic Relief Cherrysuspension262 mg/15mLoralDolgencorp, Inc. (DOLLAR GENERAL & REXALL)2009-01-07Not applicableUs
Peptic Relief Cherrysuspension262 mg/15mLoralFamily Dollar2009-07-29Not applicableUs
Peptic Relief Cherrysuspension262 mg/15mLoralSelect Brand2009-11-03Not applicableUs
Peptic Relief Cherrysuspension262 mg/15mLoralKroger2009-06-03Not applicableUs
Peptic Relief Cherrysuspension262 mg/15mLoralBest Choice2010-01-08Not applicableUs
Peptic Relief Cherrysuspension262 mg/15mLoralChain Drug Consortium, LLC2009-02-19Not applicableUs
Peptic Relief Cherrysuspension262 mg/15mLoralWalgreens2009-07-30Not applicableUs
Peptic Relief Maximum Strengthsuspension525 mg/15mLoralChain Drug Consortium, LLC2009-07-08Not applicableUs
Peptic Relief Maximum Strengthsuspension525 mg/15mLoralGood Neighbor Pharmacy2012-01-01Not applicableUs
Peptic Relief Maximum Strengthsuspension525 mg/15mLoralH.E.B2009-02-09Not applicableUs
Peptic Relief Maximum Strengthsuspension525 mg/15mLoralDollar General2009-08-06Not applicableUs
Peptic Relief Maximum Strengthsuspension525 mg/15mLoralKroger2009-06-03Not applicableUs
Peptic Relief Maximum Strengthsuspension525 mg/15mLoralAaron Industries, Inc.2013-12-11Not applicableUs
Peptic Relief Maximum Strengthsuspension525 mg/15mLoralSelect Brand2009-11-03Not applicableUs
Peptic Relief Maximum Strengthliquid1050 mg/30mLoralMarc Glassman, Inc.2015-03-31Not applicableUs
Peptic Relief Maximum Strengthsuspension525 mg/15mLoralEqualine2009-03-20Not applicableUs
Peptic Relief Maximum Strengthsuspension525 mg/15mLoralLeader2009-04-02Not applicableUs
Peptic Relief Maximum Strengthsuspension525 mg/15mLoralKroger2009-02-23Not applicableUs
Peptic Relief Original Strengthliquid262 mg/15mLoralPhysicians Total Care, Inc.2008-12-11Not applicableUs
Pepto Bismol Caplet - 262mg/caplettablet262 mgoralProcter & Gamble Inc1996-12-31Not applicableCanada
Pepto Bismol Liquid 17.6mg/mlliquid17.6 mgoralProcter & Gamble Inc1987-12-31Not applicableCanada
Pepto Relieftablet, chewable262 mg/1oralAdvance Pharmaceutical Inc.2002-01-09Not applicableUs
Pepto-bismolkitProcter & Gamble Manufacturing Company2011-09-12Not applicableUs
Pepto-bismolsuspension525 mg/30mLoralProcter & Gamble Manufacturing Company1989-03-31Not applicableUs
Pepto-bismoltablet, chewable262 mg/1oralJc World Bell Wholesale Co., Inc.2015-06-01Not applicableUs
Pepto-bismoltablet262 mg/1oralProcter & Gamble Manufacturing Company2004-06-30Not applicableUs
Pepto-bismoltablet262 mg/1oralA S Medication Solutions2004-06-30Not applicableUs
Pepto-bismoltablet525 mg/21oralProcter & Gamble Manufacturing Company2004-06-30Not applicableUs
Pepto-bismoltablet262 mg/1oralProcter & Gamble Manufacturing Company2004-06-30Not applicableUs
Pepto-bismolliquid525 mg/30mLoralA S Medication Solutions Llc1989-03-31Not applicableUs
Pepto-bismolliquid525 mg/30mLoralProcter & Gamble Manufacturing Company2004-06-30Not applicableUs
Pepto-bismoltablet, chewable262 mg/1oralLil' Drug Store Products, Inc.2010-09-16Not applicableUs
Pepto-bismolkitProcter & Gamble Manufacturing Company2012-03-05Not applicableUs
Pepto-bismol and Pepto-bismol To GokitProcter & Gamble Manufacturing Company2012-09-17Not applicableUs
Pepto-bismol Extraliquid35.2 mgoralProcter & Gamble Inc2000-02-01Not applicableCanada
Pepto-bismol Instacooltablet, chewable262 mg/1oralThe Procter & Gamble Manufacturing Company2009-07-09Not applicableUs
Pepto-bismol Max Strengthliquid1050 mg/30mLoralProcter & Gamble Manufacturing Company2004-06-30Not applicableUs
Pepto-bismol Max Strengthliquid1050 mg/30mLoralProcter & Gamble Manufacturing Company1989-03-31Not applicableUs
Pepto-bismol To Gotablet262 mg/1oralProcter & Gamble Manufacturing Company2012-03-01Not applicableUs
Pepto-bismol With Instacooltablet (chewable)262 mgoralProcter & Gamble Inc2010-01-21Not applicableCanada
Percy Medicineliquid1050 mg/10mLoralMerrick Medicine Company, Inc1920-01-01Not applicableUs
Personnel Sous-salicylate Bismuth 17.6mg/mlsuspension17.6 mgoralTherapex Division De E Z Em Canada Inc1991-12-312007-09-04Canada
Pink Bismuthliquid262 mg/15mLoralKareway Product, Inc.2011-08-29Not applicableUs
Pink Bismuthliquid262 mg/15mLoralRugby Laboratories, Inc.2012-04-01Not applicableUs
Pink Bismuthsuspension262 mg/15mLoralPharmaceutical Associates, Inc.2009-09-20Not applicableUs
Pink Bismuthtablet, chewable262 mg/1oralPreferred Pharmaceuticals, Inc2010-12-01Not applicableUs
Pink Bismuthtablet, chewable262 mg/1oralQualitest Pharmaceuticals2003-04-28Not applicableUs
Pink Bismuthliquid262 mg/15mLoralGeri Care Pharmaceuticals, Corp2000-01-01Not applicableUs
Pink Bismuth Maximum Strengthliquid525 mg/15mLoralRij Pharmaceutical Corporation1999-03-16Not applicableUs
Pink Bismuth Regular Strengthliquid525 mg/30mLoralAafes/Your Military Exchanges2015-08-31Not applicableUs
Pink Bismuth Rose Liq 17.6mg/mlliquid17.6 mgoralTechnilab Pharma Inc.1992-12-312000-09-07Canada
Pink Bismuth Subsalicylate Liq 17.6mg/mlliquid17.6 mgoralPatheon Laboratories1992-12-312000-06-21Canada
Pink Bismuth-liq 17.6mg/mlliquid17.6 mgoralPerrigo International1996-12-311998-08-12Canada
Pink-bismuthliquid262 mg/15mLoralGuardian Drug Company2008-05-30Not applicableUs
Pleasant Relief Liq 1.7%liquid1.7 %oralGolden Pride/Rawleigh1993-12-311997-02-20Canada
Regular Strength Bismuthsuspension17.6 mgoralActavis Pharma Company2014-08-13Not applicableCanada
Rexall Bismuthtablet, chewable262 mg/1oralDolgencorp Inc2012-09-28Not applicableUs
Rexall Bismuthliquid1050 mg/30mLoralDolgencorp, LLC2012-09-06Not applicableUs
Rolaids Upset Stomach Relieftablet262 mgoralPfizer Canada Inc., Consumer Healthcare DivisionNot applicableNot applicableCanada
Rx Act Stomach Relieftablet, chewable262 mg/1oralH E B1994-11-08Not applicableUs
Shoprite Stomach Reliefliquid1050 mg/30mLoralWakefern Food Corporation2013-08-14Not applicableUs
Shoprite Stomach Reliefsuspension525 mg/30mLoralWakefern Food Corporation2013-08-06Not applicableUs
Sootheliquid525 mg/30mLoralWalgreens2015-01-31Not applicableUs
Sootheliquid525 mg/30mLoralWalgreens2015-01-31Not applicableUs
Soothetablet262 mg/1oralWALGREEN CO.2011-05-06Not applicableUs
Soothetablet, chewable262 mg/1oralWALGREEN CO.1998-07-16Not applicableUs
Soothe Maximum Strengthliquid1050 mg/30mLoralWalgreens2015-04-30Not applicableUs
Sound Body Stomach Reliefsuspension525 mg/30mLoralBig Lots Stores, Inc.2015-05-29Not applicableUs
Sound Body Stomach Reliefsuspension1050 mg/30mLoralBig Lots Stores, Inc.2015-04-21Not applicableUs
Stomach Lil Drug Store Productsliquid525 mg/30mLoralLil' Drug Store Products, Inc2014-12-01Not applicableUs
Stomach Reliefsuspension525 mg/30mLoralShopko Stores Operating Co., LLC2013-11-14Not applicableUs
Stomach Relieftablet, chewable262 mg/1oralHy Vee Inc1991-08-06Not applicableUs
Stomach Relieftablet, chewable262 mg/1oralArmy and Air Force Exchange Service1998-07-16Not applicableUs
Stomach Relieftablet, chewable262 mg/1oralShopko Stores Operating Co., LLC2014-01-01Not applicableUs
Stomach Relieftablet262 mg/1oralMc Kesson2011-09-09Not applicableUs
Stomach Relieftablet, chewable262 mg/1oralHannaford Brothers Company1999-12-03Not applicableUs
Stomach Relieftablet, chewable262 mg/1oralWin Co Foods, Llc2014-12-12Not applicableUs
Stomach Reliefsuspension262 mg/15mLoralTop Care2013-11-08Not applicableUs
Stomach Relieftablet262 mg/1oralRite Aid2011-05-06Not applicableUs
Stomach Relieftablet, chewable262 mg/1oralSDA Laboratories, Inc.2012-09-27Not applicableUs
Stomach Reliefsuspension1050 mg/30mLoralRite Aid Corporation2012-07-11Not applicableUs
Stomach Relieftablet262 mg/1oralSUPERVALU INC.2011-05-06Not applicableUs
Stomach Reliefliquid262 mg/15mLoralWin Co Foods, Llc2014-12-12Not applicableUs
Stomach Relieftablet, chewable262 mg/1oralRite Aid1998-07-16Not applicableUs
Stomach Reliefliquid525 mg/30mLoralBest Choice (Valu Merchandisers Company)2015-08-31Not applicableUs
Stomach Relieftablet262 mg/1oralWal Mart Stores Inc2011-05-06Not applicableUs
Stomach Reliefliquid525 mg/30mLoralMc Kesson (Health Mart)2015-01-31Not applicableUs
Stomach Reliefsuspension1050 mg/30mLoralCVS Pharmacy1992-06-24Not applicableUs
Stomach Relieftablet262 mg/1oralBetter Living Brands, Llc2011-05-06Not applicableUs
Stomach Reliefliquid1050 mg/30mLoralShopko Stores Operating Co., LLC2013-09-19Not applicableUs
Stomach Relieftablet262 mg/1oralH E B2011-05-06Not applicableUs
Stomach Reliefsuspension1050 mg/30mLoralKroger Company1990-09-15Not applicableUs
Stomach Relief Cherryliquid525 mg/30mLoralFamily Dollar (FAMILY WELLNESS)2015-03-31Not applicableUs
Stomach Relief Cherryliquid525 mg/30mLoralFreds Inc2015-03-31Not applicableUs
Stomach Relief Cherrysuspension262 mg/15mLoralCare One2013-11-19Not applicableUs
Stomach Relief Chewablestablet, chewable262 mg/1oralKroger Company1991-10-10Not applicableUs
Stomach Relief Liquid Maximum Strengthsuspension525 mg/15mLoralSunmark2013-11-08Not applicableUs
Stomach Relief Maximum Strengthliquid1050 mg/30mLoralFamily Dollar (FAMILY WELLNESS)2014-12-31Not applicableUs
Stomach Relief Maximum Strengthliquid1050 mg/30mLoralWestern Family Foods, Inc.2015-03-31Not applicableUs
Stomach Relief Maximum Strengthsuspension1050 mg/30mLoralHy Vee Inc1989-07-15Not applicableUs
Stomach Relief Maximum Strengthliquid525 mg/15mLoralHannaford Brothers Company1995-06-29Not applicableUs
Stomach Relief Maximum Strengthliquid1050 mg/30mLoralFreds Inc2015-03-31Not applicableUs
Stomach Relief Maximum Strengthliquid1050 mg/30mLoralSelect Brand Dist.2015-09-30Not applicableUs
Stomach Relief Maximum Strengthliquid1050 mg/30mLoralEQUATE (Walmart Stores, Inc.)2014-10-31Not applicableUs
Stomach Relief Maximum Strengthliquid1050 mg/30mLoralMc Kesson (Health Mart)2014-12-31Not applicableUs
Stomach Relief Maximum Strengthliquid1050 mg/30mLoralHealthy Accents (DZA Brands, LLC)2015-02-28Not applicableUs
Stomach Relief Maximum Strengthliquid1050 mg/30mLoralSafeway, Inc.2015-06-30Not applicableUs
Stomach Relief Maximum Strengthliquid525 mg/15mLoralWestern Family Foods Inc1991-06-15Not applicableUs
Stomach Relief Maximum Strengthliquid1050 mg/30mLoralAmerisource Bergen (Good Neighbor Pharmacy) 461222015-09-30Not applicableUs
Stomach Relief Maximum Strengthliquid1050 mg/30mLoralBest Choice (Valu Merchandisers Company)2015-03-31Not applicableUs
Stomach Relief Maximum Strengthliquid1050 mg/30mLoralCVS Pharmacy, Inc.2016-01-20Not applicableUs
Stomach Relief Maximum Strength Readyincaseliquid1050 mg/30mLoralP & L Development, LLC2014-12-31Not applicableUs
Stomach Relief Multi-symptomtablet, chewable262 mg/1oralGreenbrier International, Inc.1998-07-16Not applicableUs
Stomach Relief Originalsuspension525 mg/30mLoralCVS Pharmacy1992-06-16Not applicableUs
Stomach Relief Original Formulaliquid525 mg/30mLoralPublix Supermarkets, Inc.2014-12-31Not applicableUs
Stomach Relief Original Strengthliquid525 mg/30mLoralAmerisource Bergen (Good Neighbor Pharmacy) 461222015-07-31Not applicableUs
Stomach Relief Original Strengthsuspension525 mg/30mLoralKroger Company1989-01-15Not applicableUs
Stomach Relief Original Strengthsuspension525 mg/30mLoralHy Vee Inc1989-02-15Not applicableUs
Stomach Relief Original Strengthliquid262 mg/15mLoralHannaford Brothers Company1995-06-15Not applicableUs
Stomach Relief Original Strengthliquid525 mg/30mLoralFamily Dollar (FAMILY WELLNESS)2014-12-31Not applicableUs
Stomach Relief Original Strengthliquid262 mg/15mLoralAmerisource Bergen Drug Corporation (Good Neighbor Pharmacy) 243852013-05-06Not applicableUs
Stomach Relief Original Strengthliquid262 mg/15mLoralWestern Family Foods Inc1989-03-15Not applicableUs
Stomach Relief Regular Strengthliquid525 mg/30mLoralSelect Brand Dist.2015-01-31Not applicableUs
Stomach Relief Regular Strengthliquid525 mg/30mLoralFreds Inc2015-03-31Not applicableUs
Stomach Relief Regular Strengthliquid525 mg/30mLoralEQUATE (Walmart Stores, Inc.)2014-11-30Not applicableUs
Stomach Relief Regular Strengthliquid525 mg/30mLoralTOP CARE (Topco Associates LLC)2015-02-28Not applicableUs
Stomach Relief Regular Strengthliquid525 mg/30mLoralCare One (American Sales Company)2015-01-31Not applicableUs
Stomach Relief Regular Strengthliquid525 mg/30mLoralHealthy Accents (DZA Brands, LLC)2015-03-31Not applicableUs
Stomach Relief Regular Strengthliquid525 mg/30mLoralSafeway, Inc.2015-06-30Not applicableUs
Stomach Relief Regular Strengthliquid525 mg/30mLoralWestern Family Foods, Inc.2015-01-31Not applicableUs
Stomach Relief Regular Strengthliquid525 mg/30mLoralBest Choice (Valu Merchandisers Company)2015-03-31Not applicableUs
Stomach Relief Regular Strengthliquid525 mg/30mLoralDolgencorp, Inc. (DOLLAR GENERAL & REXALL)2015-03-31Not applicableUs
Stomach Relief Regular Strengthliquid525 mg/30mLoralThe Kroger Co.2015-10-31Not applicableUs
Stomach Relief Regular Strengthliquid525 mg/30mLoralHy Vee2015-10-31Not applicableUs
Stomach Relief Regular Strengthliquid525 mg/30mLoralSelect Brand Dist.2015-07-31Not applicableUs
Stomach Relief Regular Strengthliquid525 mg/30mLoralMc Kesson (Sunmark)2015-01-31Not applicableUs
Stomach Relief Regular Strength Readyincaseliquid525 mg/30mLoralP & L Development, LLC2014-09-30Not applicableUs
Stomak-care Multi Actionsuspension35 mgoralNovartis Consumer Health Canada Inc.2005-06-202014-07-23Canada
Sun Mark Stomach Relieftablet, chewable262 mg/1oralMc Kesson2003-08-21Not applicableUs
Sunmark Stomach Reliefliquid262 mg/15mLoralMc Kesson2003-08-21Not applicableUs
Sunmark Stomach Relieftablet, chewable262 mg/1oralMc Kesson2011-03-01Not applicableUs
Sunmark Stomach Reliefsuspension525 mg/30mLoralMcKesson2016-02-12Not applicableUs
Sunmark Stomach Relief Maximum Strengthliquid525 mg/15mLoralMc Kesson2003-09-13Not applicableUs
Thredaliquid262 mg/15mLoralMenper Distributors, Inc.2012-02-21Not applicableUs
Topcare Stomach Reliefliquid1050 mg/30mLoralTopco Associates LLC1989-12-15Not applicableUs
Topcare Stomach Relief Original Strengthsuspension525 mg/30mLoralTopco Associates LLC1989-01-15Not applicableUs
Topcare Stomach Relief Original Strengthtablet, chewable262 mg/1oralTopco Associates LLC1991-09-17Not applicableUs
Up and Up 5-symptom Digestive Relieftablet262 mg/1oralTarget Corporation2015-09-07Not applicableUs
Up and Up Digestive Reliefsuspension525 mg/30mLoralTarget Corporation2015-03-10Not applicableUs
Up and Up Stomach Reliefsuspension525 mg/30mLoralTarget Corporation2013-02-13Not applicableUs
Upset Stomach Relieftablet, chewable262 mg/1oralSafeway2015-08-08Not applicableUs
Upset Stomach Relief To Gopowder525 mg/1oralBreakthrough Products Inc.2011-09-01Not applicableUs
Unapproved/Other Products Not Available
International Brands
NameCompany
Maalox Multi-ActionNot Available
Brand mixtures
NameLabellerIngredients
Bismed Chewable TabletsTechnilab Pharma Inc.
Bismuth + Antacid (chewable Tablets)Perrigo International
Bismuth Chewable TabletsVita Health Products Inc
Bismuth Tablets With Calcium CarbonateTanta Pharmaceuticals Inc
Cherry Flavour Pepto-bismol TabProcter & Gamble Inc
Chewable Bismuth Tablets With Calcium CarbonatePharmetics (2011) Inc
Pepto-bismol ChewablesProcter & Gamble Inc
Pepto-bismol TabRichardson Vicks, Division Of The Procter & Gamble Company
Pepto-bismol TabletsProcter & Gamble Inc
Pink Bismuth Plus Antacid Relief TabletsPerrigo International
Stomach Relief Chewable Flavoured TabletsGuardian Drug Company Inc
Stomach Relief Chewable TabletsGuardian Drug Company Inc
Watkins SettelzWatkins Incorporated
SaltsNot Available
Categories
UNII62TEY51RR1
CAS number14882-18-9
WeightAverage: 362.0926
Monoisotopic: 361.999166889
Chemical FormulaC7H5BiO4
InChI KeyInChIKey=ZREIPSZUJIFJNP-UHFFFAOYSA-K
InChI
InChI=1S/C7H6O3.Bi.H2O/c8-6-4-2-1-3-5(6)7(9)10;;/h1-4,8H,(H,9,10);;1H2/q;+3;/p-3
IUPAC Name
2-hydroxy-2H,4H-benzo[d]1,3-dioxa-2-bismacyclohexan-4-one
SMILES
O[Bi]1OC(=O)C2=CC=CC=C2O1
Taxonomy
DescriptionThis compound belongs to the class of organic compounds known as benzenoids. These are aromatic compounds containing one or more benzene rings.
KingdomOrganic compounds
Super ClassBenzenoids
ClassNot Available
Sub ClassNot Available
Direct ParentBenzenoids
Alternative Parents
Substituents
  • Benzenoid
  • Oxacycle
  • Organic metal salt
  • Organoheterocyclic compound
  • Monocarboxylic acid or derivatives
  • Metalloheterocycle
  • Carboxylic acid derivative
  • Hydrocarbon derivative
  • Organooxygen compound
  • Carbonyl group
  • Aromatic heteropolycyclic compound
Molecular FrameworkAromatic heteropolycyclic compounds
External Descriptors
Pharmacology
IndicationUsed to treat nausea, heartburn, indigestion, upset stomach, diarrhea, and other temporary discomforts of the stomach and gastrointestinal tract.
PharmacodynamicsBismuth subsalicylate displays anti-inflammatory action (due to salicylic acid) and also acts as an antacid and mild antibiotic. It can also cause a black tongue and black stools in some users of the drug, when it combines with trace amounts of sulfur in their saliva and gastrointestinal tract. This discoloration is temporary and harmless.
Mechanism of actionAs an antidiarrheal, the exact mechanism has not been determined. Bismuth subsalicylate may exert its antidiarrheal action not only by stimulating absorption of fluid and electrolytes across the intestinal wall (antisecretory action) but also, when hydrolyzed to salicylic acid, by inhibiting synthesis of a prostaglandin responsible for intestinal inflammation and hypermotility. In addition, bismuth subsalicylate binds toxins produced by Escherichia coli. Both bismuth subsalicylate and the intestinal reaction products, bismuth oxychloride and bismuth hydroxide, are believed to have bactericidal action. As an antacid, bismuth has weak antacid properties.
Related Articles
AbsorptionFollowing oral administration, absorption of the salicylate component from the small intestine is generally rapid and complete (>90%).
Volume of distributionNot Available
Protein bindingNot Available
Metabolism

Based on in vitro dissociation data and in vivo animal data, bismuth subsalicylate is believed to be largely hydrolyzed in the stomach to bismuth oxychloride and salicylic acid. In the small intestine, nondissociated bismuth subsalicylate reacts with other anions (bicarbonate and phosphate) to form insoluble bismuth salts. In the colon, nondissociated bismuth subsalicylate and other bismuth salts react with hydrogen sulfide to produce bismuth sulfide, a highly insoluble black salt responsible for the darkening of the stools.

Route of eliminationNot Available
Half lifeNot Available
ClearanceNot Available
ToxicityNot Available
Affected organismsNot Available
PathwaysNot Available
SNP Mediated EffectsNot Available
SNP Mediated Adverse Drug ReactionsNot Available
ADMET
Predicted ADMET features
PropertyValueProbability
Human Intestinal Absorption+0.9086
Blood Brain Barrier+0.9387
Caco-2 permeable+0.5187
P-glycoprotein substrateNon-substrate0.7003
P-glycoprotein inhibitor INon-inhibitor0.8865
P-glycoprotein inhibitor IINon-inhibitor0.9885
Renal organic cation transporterNon-inhibitor0.9091
CYP450 2C9 substrateNon-substrate0.7983
CYP450 2D6 substrateNon-substrate0.8434
CYP450 3A4 substrateNon-substrate0.6608
CYP450 1A2 substrateNon-inhibitor0.5106
CYP450 2C9 inhibitorNon-inhibitor0.6648
CYP450 2D6 inhibitorNon-inhibitor0.8639
CYP450 2C19 inhibitorNon-inhibitor0.7378
CYP450 3A4 inhibitorNon-inhibitor0.7081
CYP450 inhibitory promiscuityLow CYP Inhibitory Promiscuity0.887
Ames testNon AMES toxic0.6317
CarcinogenicityNon-carcinogens0.8734
BiodegradationNot ready biodegradable0.8052
Rat acute toxicity2.6494 LD50, mol/kg Not applicable
hERG inhibition (predictor I)Weak inhibitor0.7517
hERG inhibition (predictor II)Non-inhibitor0.9359
ADMET data is predicted using admetSAR, a free tool for evaluating chemical ADMET properties. (23092397 )
Pharmacoeconomics
ManufacturersNot Available
Packagers
Dosage forms
FormRouteStrength
Suspensionoral1050 mg/30mL
Liquidoral525 mg/15mL
Liquidoral17.66 mg
Tabletoral262 mg/434mg
Liquidoral17.6 mg
Suspensionoral17.5 mg
Tabletoral262 mg
Liquidoral17.5 mg
Suspensionoral35.2 mg
Tablet (chewable)oral
Powderoral262 mg/1
Liquidoral35 mg
Suspensionoral35 mg
Liquidoral1050 mg/30mL
Tablet, chewableoral262 mg/1
Suspensionoral525 mg/30mL
Liquidoral35 mg/mL
Liquidoral17.47 mg/mL
Piece (chewable)oral524 mg
Suspensionoral17.5 mg/mL
Suspensionoral525 mg/15mL
Tabletoral525 mg/21
Kit
Tabletoral
Liquidoral35.2 mg
Tablet (chewable)oral262 mg
Liquidoral1050 mg/10mL
Liquidoral262 mg/15mL
Suspensionoral262 mg/15mL
Liquidoral1.7 %
Suspensionoral17.6 mg
Liquidoral525 mg/30mL
Tabletoral262 mg/1
Powderoral525 mg/1
Liquidoral
Prices
Unit descriptionCostUnit
Kaopectate 262 mg caplet0.37USD caplet
Gas-x with maalox chew tablet0.25USD tablet
Bismuth subsalicylate powdr0.17USD g
Jr maalox plus antigas tablet chew0.17USD tablet
Calcium carb 500 mg tablet chew0.14USD tablet
Pepto-bismol caplet0.14USD caplet
Soothe caplets0.12USD caplet
Bismatrol 262 mg tablet0.09USD tablet
Maalox advanced tablet chew0.09USD tablet
Maalox quick dissolve tablet0.09USD tablet
Maalox max quick dissolve tablet0.06USD tablet
Stomach relief tablet0.06USD tablet
Magnesium-aluminum suspension0.03USD ml
Bismuth 262 mg/15ml susp0.02USD ml
Maalox max strength multi symp0.02USD ml
Maalox maximum strength susp0.02USD ml
Pepto-bismol max str susp0.02USD ml
Pub calcium carb 1000 mg tablet0.02USD tablet
Maalox plus x-strength susp0.01USD ml
Maalox total relief (bismuth)0.01USD ml
DrugBank does not sell nor buy drugs. Pricing information is supplied for informational purposes only.
PatentsNot Available
Properties
StateSolid
Experimental PropertiesNot Available
Predicted Properties
PropertyValueSource
Water Solubility59.7 mg/mLALOGPS
logP0.37ALOGPS
logP1.11ChemAxon
logS-0.78ALOGPS
pKa (Strongest Acidic)14.3ChemAxon
pKa (Strongest Basic)-3.1ChemAxon
Physiological Charge0ChemAxon
Hydrogen Acceptor Count3ChemAxon
Hydrogen Donor Count1ChemAxon
Polar Surface Area55.76 Å2ChemAxon
Rotatable Bond Count0ChemAxon
Refractivity35.72 m3·mol-1ChemAxon
Polarizability15.67 Å3ChemAxon
Number of Rings2ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleYesChemAxon
Spectra
Mass Spec (NIST)Not Available
Spectra
Spectrum TypeDescriptionSplash Key
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, PositiveNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, PositiveNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, PositiveNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, NegativeNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, NegativeNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, NegativeNot Available
References
Synthesis Reference

Richard William Hess, “Pigmentary bright primrose yellow monoclinic bismuth vanadate and processes for the preparation thereof.” U.S. Patent US4115142, issued December, 1925.

US4115142
General References
  1. Goldenberg MM, Honkomp LJ, Burrous SE, Castellion AW: Protective effect of Pepto-Bismol liquid on the gastric mucosa of rats. Gastroenterology. 1975 Sep;69(3):636-40. [PubMed:1158081 ]
External Links
ATC CodesNot Available
AHFS Codes
  • 52:92.00
  • 56:04.00
  • 56:08.00
  • 84:92.00
  • 92:02.00*
PDB EntriesNot Available
FDA labelNot Available
MSDSDownload (73.6 KB)
Interactions
Drug Interactions
Drug
AbciximabBismuth Subsalicylate may increase the anticoagulant activities of Abciximab.
AcenocoumarolBismuth Subsalicylate may increase the anticoagulant activities of Acenocoumarol.
AcetazolamideThe risk or severity of adverse effects can be increased when Bismuth Subsalicylate is combined with Acetazolamide.
Acetylsalicylic acidAcetylsalicylic acid may increase the anticoagulant activities of Bismuth Subsalicylate.
AlteplaseThe risk or severity of adverse effects can be increased when Bismuth Subsalicylate is combined with Alteplase.
Ammonium chlorideThe serum concentration of Bismuth Subsalicylate can be increased when it is combined with Ammonium chloride.
AnistreplaseThe risk or severity of adverse effects can be increased when Bismuth Subsalicylate is combined with Anistreplase.
Bismuth SubcitrateBismuth Subsalicylate may increase the neurotoxic activities of Bismuth Subcitrate.
Citric AcidBismuth Subsalicylate may increase the anticoagulant activities of Citric Acid.
DalteparinBismuth Subsalicylate may increase the anticoagulant activities of Dalteparin.
DemeclocyclineThe serum concentration of Demeclocycline can be decreased when it is combined with Bismuth Subsalicylate.
DesmopressinThe risk or severity of adverse effects can be increased when Desmopressin is combined with Bismuth Subsalicylate.
DexketoprofenThe risk or severity of adverse effects can be increased when Bismuth Subsalicylate is combined with Dexketoprofen.
DiclofenamideThe risk or severity of adverse effects can be increased when Bismuth Subsalicylate is combined with Diclofenamide.
DicoumarolBismuth Subsalicylate may increase the anticoagulant activities of Dicoumarol.
DoxycyclineThe serum concentration of Doxycycline can be decreased when it is combined with Bismuth Subsalicylate.
Edetic AcidBismuth Subsalicylate may increase the anticoagulant activities of Edetic Acid.
EnoxaparinBismuth Subsalicylate may increase the anticoagulant activities of Enoxaparin.
EthoxzolamideThe risk or severity of adverse effects can be increased when Bismuth Subsalicylate is combined with Ethoxzolamide.
Ethyl biscoumacetateBismuth Subsalicylate may increase the anticoagulant activities of Ethyl biscoumacetate.
FludrocortisoneThe risk or severity of adverse effects can be increased when Bismuth Subsalicylate is combined with Fludrocortisone.
Fondaparinux sodiumBismuth Subsalicylate may increase the anticoagulant activities of Fondaparinux sodium.
Ginkgo bilobaGinkgo biloba may increase the anticoagulant activities of Bismuth Subsalicylate.
HeparinBismuth Subsalicylate may increase the anticoagulant activities of Heparin.
HyaluronidaseThe therapeutic efficacy of Hyaluronidase can be decreased when used in combination with Bismuth Subsalicylate.
Insulin HumanBismuth Subsalicylate may increase the hypoglycemic activities of Insulin Regular.
MethotrexateThe serum concentration of Methotrexate can be increased when it is combined with Bismuth Subsalicylate.
MinocyclineThe serum concentration of Minocycline can be decreased when it is combined with Bismuth Subsalicylate.
OxytetracyclineThe serum concentration of Oxytetracycline can be decreased when it is combined with Bismuth Subsalicylate.
PerindoprilBismuth Subsalicylate may decrease the antihypertensive activities of Perindopril.
PhenindioneBismuth Subsalicylate may increase the anticoagulant activities of Phenindione.
PhenprocoumonBismuth Subsalicylate may increase the anticoagulant activities of Phenprocoumon.
PralatrexateThe serum concentration of Pralatrexate can be increased when it is combined with Bismuth Subsalicylate.
ProbenecidThe therapeutic efficacy of Probenecid can be decreased when used in combination with Bismuth Subsalicylate.
ReteplaseThe risk or severity of adverse effects can be increased when Bismuth Subsalicylate is combined with Reteplase.
RidogrelThe risk or severity of adverse effects can be increased when Bismuth Subsalicylate is combined with Ridogrel.
StreptokinaseThe risk or severity of adverse effects can be increased when Bismuth Subsalicylate is combined with Streptokinase.
SulodexideBismuth Subsalicylate may increase the anticoagulant activities of Sulodexide.
TenecteplaseThe risk or severity of adverse effects can be increased when Bismuth Subsalicylate is combined with Tenecteplase.
TetracyclineThe serum concentration of Tetracycline can be decreased when it is combined with Bismuth Subsalicylate.
TorasemideBismuth Subsalicylate may decrease the diuretic activities of Torasemide.
TreprostinilThe risk or severity of adverse effects can be increased when Treprostinil is combined with Bismuth Subsalicylate.
UrokinaseThe risk or severity of adverse effects can be increased when Bismuth Subsalicylate is combined with Urokinase.
Valproic AcidThe serum concentration of Valproic Acid can be increased when it is combined with Bismuth Subsalicylate.
WarfarinBismuth Subsalicylate may increase the anticoagulant activities of Warfarin.
Food InteractionsNot Available

Carriers

Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
binder
General Function:
Toxic substance binding
Specific Function:
Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc.
Gene Name:
ALB
Uniprot ID:
P02768
Molecular Weight:
69365.94 Da
References
  1. Sun H, Li H, Mason AB, Woodworth RC, Sadler PJ: Competitive binding of bismuth to transferrin and albumin in aqueous solution and in blood plasma. J Biol Chem. 2001 Mar 23;276(12):8829-35. Epub 2000 Dec 7. [PubMed:11110794 ]
  2. Sun H, Szeto KY: Binding of bismuth to serum proteins: implication for targets of Bi(III) in blood plasma. J Inorg Biochem. 2003 Feb 1;94(1-2):114-20. [PubMed:12620681 ]
  3. Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. [PubMed:11752352 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
General Function:
Transferrin receptor binding
Specific Function:
Transferrins are iron binding transport proteins which can bind two Fe(3+) ions in association with the binding of an anion, usually bicarbonate. It is responsible for the transport of iron from sites of absorption and heme degradation to those of storage and utilization. Serum transferrin may also have a further role in stimulating cell proliferation.
Gene Name:
TF
Uniprot ID:
P02787
Molecular Weight:
77063.195 Da
References
  1. Sun H, Li H, Mason AB, Woodworth RC, Sadler PJ: Competitive binding of bismuth to transferrin and albumin in aqueous solution and in blood plasma. J Biol Chem. 2001 Mar 23;276(12):8829-35. Epub 2000 Dec 7. [PubMed:11110794 ]
  2. Sun H, Szeto KY: Binding of bismuth to serum proteins: implication for targets of Bi(III) in blood plasma. J Inorg Biochem. 2003 Feb 1;94(1-2):114-20. [PubMed:12620681 ]
  3. Zhang M, Gumerov DR, Kaltashov IA, Mason AB: Indirect detection of protein-metal binding: interaction of serum transferrin with In3+ and Bi3+. J Am Soc Mass Spectrom. 2004 Nov;15(11):1658-64. [PubMed:15519234 ]
  4. Miquel G, Nekaa T, Kahn PH, Hemadi M, El Hage Chahine JM: Mechanism of formation of the complex between transferrin and bismuth, and interaction with transferrin receptor 1. Biochemistry. 2004 Nov 23;43(46):14722-31. [PubMed:15544343 ]
  5. Ge R, Sun H: Bioinorganic chemistry of bismuth and antimony: target sites of metallodrugs. Acc Chem Res. 2007 Apr;40(4):267-74. Epub 2007 Mar 2. [PubMed:17330963 ]
Comments
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Drug created on June 30, 2007 08:17 / Updated on August 17, 2016 12:23