You are using an unsupported browser. Please upgrade your browser to a newer version to get the best experience on DrugBank.
Identification
NameBismuth Subsalicylate
Accession NumberDB01294  (DB01402)
TypeSmall Molecule
GroupsApproved
Description

Bismuth subsalicylate is the active ingredient in the popular medication Pepto-Bismol that is used to treat nausea, heartburn, indigestion, upset stomach, diarrhea, and other temporary discomforts of the stomach and gastrointestinal tract. It is also the main ingredient of Kaopectate. It displays anti-inflammatory action (due to salicylic acid) and also acts as an antacid and mild antibiotic.

Structure
Thumb
Synonyms
SynonymLanguageCode
2-Hydroxy-benzo[1,3,2]dioxabismin-4-oneNot AvailableNot Available
Basic bismuth salicylateNot AvailableNot Available
Bismuth oxide salicylateNot AvailableNot Available
Bismuth oxysalicylateNot AvailableNot Available
Bismuth subsalicylateNot AvailableNot Available
pink bismuthNot AvailableNot Available
WismutsubsalicylatNot AvailableNot Available
Prescription ProductsNot Available
Generic Prescription ProductsNot Available
Over the Counter Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Good Sense Stomach Relief original strengthsuspension525 mg/30mLoralL. Perrigo Company1989-09-15Not AvailableUs
Good Sense Stomach Reliefliquid1050 mg/30mLoralL. Perrigo Company1990-01-15Not AvailableUs
Good Sense Stomach Relieftablet, chewable262 mgoralL Perrigo Company1993-08-24Not AvailableUs
Pink Bismuthsuspension262 mg/15mLoralPharmaceutical Associates, Inc.2009-09-20Not AvailableUs
Percy Medicineliquid1050 mg/10mLoralMerrick Medicine Company, Inc1920-01-01Not AvailableUs
Peptic Reliefsuspension262 mg/15mLoralWalgreens2009-07-02Not AvailableUs
Sootheliquid525 mg/30mLoralWalgreens2015-01-31Not AvailableUs
Peptic Relief Cherrysuspension262 mg/15mLoralWalgreens2009-07-30Not AvailableUs
Soothetablet, chewable262 mgoralWALGREEN CO.1998-07-16Not AvailableUs
Stomach Reliefcapsule262 mgoralWALGREEN CO.2011-05-06Not AvailableUs
Pink Bismuthliquid262 mg/15mLoralRugby Laboratories, Inc.2012-04-01Not AvailableUs
Bismuth Subsalicylatetablet262 mgoralRugby Laboratories Inc.1996-01-23Not AvailableUs
Pink Bismuthtablet, chewable262 mgoralQualitest Pharmaceuticals2003-04-28Not AvailableUs
Bismatrolliquid262 mg/15mLoralMajor Pharmaceuticals2008-05-30Not AvailableUs
Bismatrolliquid525 mg/15mLoralMajor Pharmaceuticals2009-01-05Not AvailableUs
Bismatroltablet, chewable262 mgoralMajor Pharmaceuticals2003-01-03Not AvailableUs
Kao-tin Peppermint Flavorliquid262 mg/15mLoralMAJOR Pharmaceuticals Inc.2011-02-14Not AvailableUs
7 Select Pink Bismuthsuspension1050 mg/30mLoral7 Eleven2014-04-17Not AvailableUs
Kola-pectin DSliquid525 mg/15mLoralSeyer Pharmatec, Inc.2007-10-01Not AvailableUs
Peptic Reliefsuspension262 mg/15mLoralRite Aid2009-06-03Not AvailableUs
Peptic Reliefsuspension262 mg/15mLoralRite Aid2009-10-16Not AvailableUs
Peptic Reliefsuspension525 mg/15mLoralRite Aid2009-09-23Not AvailableUs
Stomach Relieftablet, chewable262 mgoralRite Aid1998-07-16Not AvailableUs
Stomach Reliefsuspension1050 mg/30mLoralRite Aid Corporation2012-07-11Not AvailableUs
Stomach Reliefcapsule262 mgoralRite Aid2011-05-06Not AvailableUs
Desempacho Cucharadasliquid262 mg/15mLoralPharmalab Enterprises Inc.2009-01-09Not AvailableUs
Peptic Reliefsuspension262 mg/15mLoralSelect Brand2009-11-03Not AvailableUs
Peptic Reliefsuspension262 mg/15mLoralSelect Brand2009-06-03Not AvailableUs
Peptic Relief Cherrysuspension262 mg/15mLoralSelect Brand2009-11-03Not AvailableUs
Peptic Relief Maximum Strengthsuspension525 mg/15mLoralSelect Brand2009-11-03Not AvailableUs
Pepto Relieftablet, chewable262 mgoralAdvance Pharmaceutical Inc.2002-01-09Not AvailableUs
Bismatrolliquid262 mg/15mLoralAtlantic Biologicals Corps2008-05-30Not AvailableUs
Peptic Reliefsuspension262 mg/15mLoralGood Neighbor Pharmacy2009-09-18Not AvailableUs
Peptic Reliefsuspension262 mg/15mLoralKroger2009-02-23Not AvailableUs
Peptic Relief Maximum Strengthsuspension525 mg/15mLoralKroger2009-02-23Not AvailableUs
Peptic Relief Cherrysuspension262 mg/15mLoralKroger2009-06-03Not AvailableUs
Peptic Reliefsuspension262 mg/15mLoralKroger2009-06-03Not AvailableUs
Peptic Relief Maximum Strengthsuspension525 mg/15mLoralKroger2009-06-03Not AvailableUs
Stomach Relief original strengthliquid262 mg/15mLoralKroger Company1989-01-15Not AvailableUs
Stomach Reliefliquid525 mg/15mLoralKroger Company1990-09-15Not AvailableUs
Stomach Relief chewablestablet, chewable262 mgoralKroger Company1991-10-10Not AvailableUs
Topcare Stomach Relief original strengthsuspension525 mg/30mLoralTopco Associates LLC1989-01-15Not AvailableUs
Topcare Stomach Reliefliquid1050 mg/30mLoralTopco Associates LLC1989-12-15Not AvailableUs
Topcare Stomach Relief Original Strengthtablet, chewable262 mgoralTopco Associates LLC1991-09-17Not AvailableUs
Pepto-bismol To Gotablet262 mgoralProcter & Gamble Manufacturing Company2012-03-01Not AvailableUs
Pepto-bismoltablet525 mg/21oralProcter & Gamble Manufacturing Company2004-06-30Not AvailableUs
Pepto-bismol Max Strengthliquid1050 mg/30mLoralProcter & Gamble Manufacturing Company1989-03-31Not AvailableUs
Pepto-bismolsuspension525 mg/30mLoralProcter & Gamble Manufacturing Company1989-03-31Not AvailableUs
Pepto-bismolkitProcter & Gamble Manufacturing Company2011-09-12Not AvailableUs
Pepto-bismolkitProcter & Gamble Manufacturing Company2012-03-05Not AvailableUs
Pepto-bismolliquid525 mg/30mLoralProcter & Gamble Manufacturing Company2004-06-30Not AvailableUs
Pepto-bismoltablet262 mgoralProcter & Gamble Manufacturing Company2004-06-30Not AvailableUs
Pepto-bismoltablet262 mgoralProcter & Gamble Manufacturing Company2004-06-30Not AvailableUs
Pepto-bismol Max Strengthliquid1050 mg/30mLoralProcter & Gamble Manufacturing Company2004-06-30Not AvailableUs
Pepto-bismol InstaCooltablet, chewable262 mgoralThe Procter & Gamble Manufacturing Company2009-07-09Not AvailableUs
Stomach Reliefsuspension525 mg/30mLoralShopko Stores Operating Co., LLC2013-11-14Not AvailableUs
Stomach Reliefliquid1050 mg/30mLoralShopko Stores Operating Co., LLC2013-09-19Not AvailableUs
Stomach Relieftablet, chewable262 mgoralShopko Stores Operating Co., LLC2014-01-01Not AvailableUs
Peptic Reliefsuspension262 mg/15mLoralLeader2009-07-30Not AvailableUs
Peptic Reliefsuspension262 mg/15mLoralLeader2009-04-02Not AvailableUs
Peptic Relief Maximum Strengthsuspension525 mg/15mLoralLeader2009-04-02Not AvailableUs
Leader Stomach Relief original strengthtablet, chewable262 mgoralCardinal Health1997-10-07Not AvailableUs
Leader Stomach Reliefliquid262 mg/15mLoralCardinal Health1990-04-15Not AvailableUs
Leader Stomach Reliefliquid525 mg/15mLoralCardinal Health1994-11-09Not AvailableUs
Stomach Reliefcapsule262 mgoralH E B2011-05-06Not AvailableUs
Rx Act Stomach Relieftablet, chewable262 mgoralH E B1994-11-08Not AvailableUs
Equaline Stomach Reliefliquid262 mg/15mLoralSupervalu Inc2004-10-14Not AvailableUs
Peptic Reliefsuspension262 mg/15mLoralEqualine2009-03-20Not AvailableUs
Peptic Reliefsuspension262 mg/15mLoralEqualine2009-03-20Not AvailableUs
Peptic Reliefsuspension262 mg/15mLoralEqualine2009-03-20Not AvailableUs
Peptic Relief Maximum Strengthsuspension525 mg/15mLoralEqualine2009-04-02Not AvailableUs
Peptic Relief Maximum Strengthsuspension525 mg/15mLoralEqualine2009-03-20Not AvailableUs
Stomach Relieftablet262 mgoralSUPERVALU INC.2011-05-06Not AvailableUs
Equaline Stomach Reliefsuspension1050 mg/30mLoralSupervalu Inc2004-10-07Not AvailableUs
Kaopectate Regular Strength Peppermint Flavor Anti Diarrhealliquid17.47 mg/mLoralChattem, Inc.2003-04-01Not AvailableUs
Kaopectate Regular Strength Vanilla Flavor Anti Diarrhealliquid262 mg/15mLoralChattem, Inc.2003-04-01Not AvailableUs
Kaopectate Regular Strength Cherry Flavorliquid262 mg/15mLoralChattem, Inc.2004-04-30Not AvailableUs
Kaopectate Extra Strength Peppermint Flavor Anti Diarrhealliquid35 mg/mLoralChattem, Inc.2003-04-01Not AvailableUs
Shoprite Stomach Reliefsuspension525 mg/30mLoralWakefern Food Corporation2013-08-06Not AvailableUs
Shoprite Stomach Reliefliquid1050 mg/30mLoralWakefern Food Corporation2013-08-14Not AvailableUs
Stomach Relief Original Strengthliquid262 mg/15mLoralHannaford Brothers Company1995-06-15Not AvailableUs
Stomach Relief Maximum Strengthliquid525 mg/15mLoralHannaford Brothers Company1995-06-29Not AvailableUs
Stomach Relieftablet, chewable262 mgoralHannaford Brothers Company1999-12-03Not AvailableUs
Careone Stomach Reliefsuspension525 mg/30mLoralAmerican Sales Company2012-08-05Not AvailableUs
Careone Stomach Reliefsuspension1050 mg/30mLoralAmerican Sales Company2012-08-05Not AvailableUs
Stomach Relief Regular Strengthliquid525 mg/30mLoralCare One (American Sales Company)2015-01-31Not AvailableUs
Stomach Relief original strengthsuspension525 mg/30mLoralHy Vee Inc1989-02-15Not AvailableUs
Stomach Relief Maximum Strengthsuspension1050 mg/30mLoralHy Vee Inc1989-07-15Not AvailableUs
Stomach Relieftablet, chewable262 mgoralHy Vee Inc1991-08-06Not AvailableUs
Being Well Stomach Relief original strengthsuspension525 mg/30mLoralSave A Lot Food Stores Ltd2006-02-25Not AvailableUs
Medique Diotamesuspension262 mg/15mLoralUnique First Aid Corporation2011-04-05Not AvailableUs
Medique Diotametablet, chewable262 mgoralUnifirst First Aid Corporation2014-04-01Not AvailableUs
Medique Diotametablet, chewable262 mgoralUnifirst First Aid Corporation2008-12-302017-07-22Us
Medi-first Pep-t-medtablet, chewable262 mgoralUnifirst First Aid Corporation2011-12-01Not AvailableUs
Equate Stomach Relief regular strengthliquid262 mg/15mLoralWal Mart Stores Inc1989-12-15Not AvailableUs
Equate Stomach Relief Maximum Strengthliquid1050 mg/30mLoralWal Mart Stores Inc2001-02-02Not AvailableUs
Stomach Reliefcapsule262 mgoralWal Mart Stores Inc2011-05-06Not AvailableUs
Stomach Relief Maximum Strengthliquid1050 mg/30mLoralEQUATE (Walmart Stores, Inc.)2014-10-31Not AvailableUs
Stomach Relief Regular Strengthliquid525 mg/30mLoralEQUATE (Walmart Stores, Inc.)2014-11-30Not AvailableUs
Sun Mark Stomach Relieftablet, chewable262 mgoralMc Kesson2003-08-21Not AvailableUs
Sunmark Stomach Reliefliquid262 mg/15mLoralMc Kesson2003-08-21Not AvailableUs
Sunmark Stomach Relief Maximum Strengthliquid525 mg/15mLoralMc Kesson2003-09-13Not AvailableUs
Stomach Relieftablet262 mgoralMc Kesson2011-09-09Not AvailableUs
Stomach Relief Regular Strengthliquid525 mg/30mLoralMc Kesson (Sunmark)2015-01-31Not AvailableUs
Sunmark Stomach Relieftablet, chewable262 mgoralMc Kesson2011-03-01Not AvailableUs
Stomach Relief Maximum Strength ReadyInCaseliquid1050 mg/30mLoralAaron Industries Inc.2014-12-31Not AvailableUs
Stomach Relief Regular Strength ReadyInCaseliquid525 mg/30mLoralAaron Industries Inc.2014-09-30Not AvailableUs
Leader Stomach Reliefsuspension525 mg/30mLoralCardinal Health1990-04-15Not AvailableUs
Leader Stomach Reliefsuspension1050 mg/30mLoralCardinal Health2014-02-20Not AvailableUs
Bismoltablet262 mg/434mgoralSAMSUNG PHARM IND. CO., LTD.2013-02-01Not AvailableUs
Upset Stomach Relief To Gopowder525 mgoralBreakthrough Products Inc.2011-09-01Not AvailableUs
Pink-bismuthliquid262 mg/15mLoralGuardian Drug Company2008-05-30Not AvailableUs
Bismatroltablet, chewable262 mgoralAidarex Pharmaceuticals LLC2003-01-03Not AvailableUs
Bismatrolliquid262 mg/15mLoralAidarex Pharmaceuticals LLC2008-05-30Not AvailableUs
Bismuthliquid262 mg/15mLoralRij Pharmaceutical Corporation1999-03-16Not AvailableUs
Pink Bismuth Maximum Strengthliquid525 mg/15mLoralRij Pharmaceutical Corporation1999-03-16Not AvailableUs
Kao-bisliquid262 mg/15mLoralRij Pharmaceutical Corporation1999-03-16Not AvailableUs
Ka Pecliquid262 mg/15mLoralRij Pharmaceutical Corporation1999-03-16Not AvailableUs
Pepto-bismolliquid525 mg/30mLoralA S Medication Solutions Llc1989-03-31Not AvailableUs
Kaopectate Regular Strength Vanilla Flavor Anti Diarrhealliquid262 mg/15mLoralPhysicians Total Care, Inc.2008-05-12Not AvailableUs
Peptic Relief original strengthliquid262 mg/15mLoralPhysicians Total Care, Inc.2008-12-11Not AvailableUs
Green Reliefliquid262 mg/15mLoralGreen Choice for Life2012-02-21Not AvailableUs
Stomach Relieftablet, chewable262 mgoralArmy and Air Force Exchange Service1998-07-16Not AvailableUs
Stomach Relief original strengthliquid262 mg/15mLoralWestern Family Foods Inc1989-03-15Not AvailableUs
Stomach Relief Maximum Strengthliquid525 mg/15mLoralWestern Family Foods Inc1991-06-15Not AvailableUs
Stomach Relief Regular Strengthliquid525 mg/30mLoralWestern Family Foods, Inc.2015-01-31Not AvailableUs
Healthy Accents Stomach Relief original strengthsuspension525 mg/30mLoralDZA Brands LLC2008-01-22Not AvailableUs
Healthy Accents Stomach Reliefliquid1050 mg/30mLoralDZA Brands LLC2008-01-22Not AvailableUs
Healthy Accents Stomach Relieftablet, chewable262 mgoralDZA Brands LLC2012-01-02Not AvailableUs
Peptic Relief Cherrysuspension262 mg/15mLoralFamily Dollar2009-07-29Not AvailableUs
Stomach Relief Maximum Strengthliquid1050 mg/30mLoralFamily Dollar (FAMILY WELLNESS)2014-12-31Not AvailableUs
Stomach Relief Original Strengthliquid525 mg/30mLoralFamily Dollar (FAMILY WELLNESS)2014-12-31Not AvailableUs
Moore Medical Bismuthtablet, chewable262 mgoralMoore Medical LLC2008-12-302017-07-22Us
Moore Medical Bismuthtablet, chewable262 mgoralMoore Medical LLC2014-04-01Not AvailableUs
Estomaxliquid262 mg/15mLoralPharmadel LLC2012-02-21Not AvailableUs
Peptic Relief Maximum Strengthsuspension525 mg/15mLoralDollar General2009-08-06Not AvailableUs
Peptic Relief Cherrysuspension262 mg/15mLoralDollar General2009-01-07Not AvailableUs
Rexall Bismuthliquid1050 mg/30mLoralDolgencorp, LLC2012-09-06Not AvailableUs
Rexall Bismuthtablet, chewable262 mgoralDolgencorp Inc2012-09-28Not AvailableUs
Bismuth Tabstablet, chewable262 mgoralDolgencorp, LLC1998-07-16Not AvailableUs
Dg Health Stomach Relief maximum strengthliquid1050 mg/30mLoralDolgencorp Inc2012-09-09Not AvailableUs
Original Formula stomach reliefliquid262 mg/15mLoralPublix Super Markets Inc1995-03-29Not AvailableUs
Maximum Strengthliquid525 mg/15mLoralPublix Super Markets Inc2002-08-08Not AvailableUs
Stomach Relief Original Formulaliquid525 mg/30mLoralPublix Supermarkets, Inc.2014-12-31Not AvailableUs
Chewabletablet, chewable262 mgoralPublix Super Markets Inc2001-03-15Not AvailableUs
Geri-pectate Vanilla Flavorliquid262 mg/15mLoralGeri Care Pharmaceuticals, Corp2000-01-01Not AvailableUs
Pink Bismuthliquid262 mg/15mLoralGeri Care Pharmaceuticals, Corp2000-01-01Not AvailableUs
Geri-pectate Peppermint Flavorliquid262 mg/15mLoralGeri Care Pharmaceuticals, Corp2000-01-01Not AvailableUs
Peptic Reliefsuspension262 mg/15mLoralH.E.B2009-02-09Not AvailableUs
Peptic Relief Maximum Strengthsuspension525 mg/15mLoralH.E.B2009-02-09Not AvailableUs
Stomach Relief originalsuspension525 mg/30mLoralCVS Pharmacy1992-06-16Not AvailableUs
Stomach Reliefliquid1050 mg/30mLoralCVS Pharmacy1992-06-24Not AvailableUs
Stomach Reliefliquid525 mg/30mLoralMc Kesson (Health Mart)2015-01-31Not AvailableUs
Stomach Relief Maximum Strengthliquid1050 mg/30mLoralMc Kesson (Health Mart)2014-12-31Not AvailableUs
Health Mart Stomach Relieftablet, chewable262 mgoralMc Kesson2012-04-01Not AvailableUs
Bismuth Subsalicylatetablet, chewable262 mgoralA&Z Pharmaceutical, Inc.2003-03-10Not AvailableUs
Peptic Reliefsuspension262 mg/15mLoralKinray, Inc2009-06-03Not AvailableUs
Peptic Reliefsuspension262 mg/15mLoralBest Choice2009-02-03Not AvailableUs
Peptic Relief Cherrysuspension262 mg/15mLoralBest Choice2010-01-08Not AvailableUs
Peptic Reliefsuspension262 mg/15mLoralBest Choice2009-01-16Not AvailableUs
Stomach Relieftablet, chewable262 mgoralSDA Laboratories, Inc.2012-09-27Not AvailableUs
Circle K Stomachliquid525 mg/30mLoralLil' Drug Store Products, Inc2014-11-01Not AvailableUs
Stomach Lil Drug Store Productsliquid525 mg/30mLoralLil' Drug Store Products, Inc2014-12-01Not AvailableUs
Pepto-bismoltablet, chewable262 mgoralLil' Drug Store Products, Inc.2010-09-16Not AvailableUs
7-select Pepto Bismoltablet, chewable262 mgoralLil' Drug Store Products, Inc2011-08-01Not AvailableUs
Stomach Reliefliquid262 mg/15mLoralWin Co Foods, Llc2014-12-12Not AvailableUs
Maximum Strength Stomach Reliefliquid525 mg/15mLoralWin Co Foods, Llc2014-12-12Not AvailableUs
Stomach Relieftablet, chewable262 mgoralWin Co Foods, Llc2014-12-12Not AvailableUs
Pink Bismuthliquid262 mg/15mLoralKareway Product, Inc.2011-08-29Not AvailableUs
Peptic Reliefsuspension262 mg/15mLoralPremier Value2009-08-13Not AvailableUs
Peptic Relief Maximum Strengthsuspension525 mg/15mLoralPremier Value2009-07-08Not AvailableUs
Peptic Relief Cherrysuspension262 mg/15mLoralPremier Value2009-02-19Not AvailableUs
Pink Bismuthtablet, chewable262 mgoralPreferred Pharmaceuticals, Inc2010-12-01Not AvailableUs
Bismuthtablet262 mgoralAllegiant Health2014-12-23Not AvailableUs
Bismuthtablet262 mgoralPharmetics (2011) IncNot AvailableNot AvailableCanada
Bismuthliquid17.6 mgoralPerrigo InternationalNot AvailableNot AvailableCanada
International Brands
NameCompany
Maalox Multi-ActionNot Available
Brand mixtures
Brand NameIngredients
Pepto-Bismol ChewablesBismuth Subsalicylate + Calcium Carbonate
Watkins SettelzBismuth Subsalicylate + Pectin + Phenyl Salicylate
SaltsNot Available
Categories
CAS number14882-18-9
WeightAverage: 362.0926
Monoisotopic: 361.999166889
Chemical FormulaC7H5BiO4
InChI KeyZREIPSZUJIFJNP-UHFFFAOYSA-K
InChI
InChI=1S/C7H6O3.Bi.H2O/c8-6-4-2-1-3-5(6)7(9)10;;/h1-4,8H,(H,9,10);;1H2/q;+3;/p-3
IUPAC Name
2-hydroxy-2H,4H-benzo[d]1,3-dioxa-2-bismacyclohexan-4-one
SMILES
O[Bi]1OC(=O)C2=CC=CC=C2O1
Taxonomy
DescriptionThis compound belongs to the class of organic compounds known as benzenoids. These are aromatic compounds containing one or more benzene rings.
KingdomOrganic compounds
Super ClassBenzenoids
ClassNot Available
Sub ClassNot Available
Direct ParentBenzenoids
Alternative Parents
Substituents
  • Benzenoid
  • Oxacycle
  • Organic metal salt
  • Organoheterocyclic compound
  • Monocarboxylic acid or derivatives
  • Metalloheterocycle
  • Carboxylic acid derivative
  • Hydrocarbon derivative
  • Organooxygen compound
  • Carbonyl group
  • Aromatic heteropolycyclic compound
Molecular FrameworkAromatic heteropolycyclic compounds
External Descriptors
Pharmacology
IndicationUsed to treat nausea, heartburn, indigestion, upset stomach, diarrhea, and other temporary discomforts of the stomach and gastrointestinal tract.
PharmacodynamicsBismuth subsalicylate displays anti-inflammatory action (due to salicylic acid) and also acts as an antacid and mild antibiotic. It can also cause a black tongue and black stools in some users of the drug, when it combines with trace amounts of sulfur in their saliva and gastrointestinal tract. This discoloration is temporary and harmless.
Mechanism of actionAs an antidiarrheal, the exact mechanism has not been determined. Bismuth subsalicylate may exert its antidiarrheal action not only by stimulating absorption of fluid and electrolytes across the intestinal wall (antisecretory action) but also, when hydrolyzed to salicylic acid, by inhibiting synthesis of a prostaglandin responsible for intestinal inflammation and hypermotility. In addition, bismuth subsalicylate binds toxins produced by Escherichia coli. Both bismuth subsalicylate and the intestinal reaction products, bismuth oxychloride and bismuth hydroxide, are believed to have bactericidal action. As an antacid, bismuth has weak antacid properties.
AbsorptionFollowing oral administration, absorption of the salicylate component from the small intestine is generally rapid and complete (>90%).
Volume of distributionNot Available
Protein bindingNot Available
Metabolism

Based on in vitro dissociation data and in vivo animal data, bismuth subsalicylate is believed to be largely hydrolyzed in the stomach to bismuth oxychloride and salicylic acid. In the small intestine, nondissociated bismuth subsalicylate reacts with other anions (bicarbonate and phosphate) to form insoluble bismuth salts. In the colon, nondissociated bismuth subsalicylate and other bismuth salts react with hydrogen sulfide to produce bismuth sulfide, a highly insoluble black salt responsible for the darkening of the stools.

Route of eliminationNot Available
Half lifeNot Available
ClearanceNot Available
ToxicityNot Available
Affected organismsNot Available
PathwaysNot Available
SNP Mediated EffectsNot Available
SNP Mediated Adverse Drug ReactionsNot Available
ADMET
Predicted ADMET features
PropertyValueProbability
Human Intestinal Absorption+0.9086
Blood Brain Barrier+0.9387
Caco-2 permeable+0.5187
P-glycoprotein substrateNon-substrate0.7003
P-glycoprotein inhibitor INon-inhibitor0.8865
P-glycoprotein inhibitor IINon-inhibitor0.9885
Renal organic cation transporterNon-inhibitor0.9091
CYP450 2C9 substrateNon-substrate0.7983
CYP450 2D6 substrateNon-substrate0.8434
CYP450 3A4 substrateNon-substrate0.6608
CYP450 1A2 substrateNon-inhibitor0.5106
CYP450 2C9 substrateNon-inhibitor0.6648
CYP450 2D6 substrateNon-inhibitor0.8639
CYP450 2C19 substrateNon-inhibitor0.7378
CYP450 3A4 substrateNon-inhibitor0.7081
CYP450 inhibitory promiscuityLow CYP Inhibitory Promiscuity0.887
Ames testNon AMES toxic0.6317
CarcinogenicityNon-carcinogens0.8734
BiodegradationNot ready biodegradable0.8052
Rat acute toxicity2.6494 LD50, mol/kg Not applicable
hERG inhibition (predictor I)Weak inhibitor0.7517
hERG inhibition (predictor II)Non-inhibitor0.9359
Pharmacoeconomics
ManufacturersNot Available
Packagers
Dosage forms
FormRouteStrength
Capsuleoral262 mg
Kit
Liquidoral1050 mg/10mL
Liquidoral1050 mg/30mL
Liquidoral17.47 mg/mL
Liquidoral17.6 mg
Liquidoral262 mg/15mL
Liquidoral35 mg/mL
Liquidoral525 mg/15mL
Liquidoral525 mg/30mL
Powderoral525 mg
Suspensionoral1050 mg/30mL
Suspensionoral262 mg/15mL
Suspensionoral525 mg/15mL
Suspensionoral525 mg/30mL
Tabletoral262 mg
Tabletoral262 mg/434mg
Tabletoral525 mg/21
Tablet, chewableoral262 mg
Prices
Unit descriptionCostUnit
Kaopectate 262 mg caplet0.37USD caplet
Gas-x with maalox chew tablet0.25USD tablet
Bismuth subsalicylate powdr0.17USD g
Jr maalox plus antigas tablet chew0.17USD tablet
Calcium carb 500 mg tablet chew0.14USD tablet
Pepto-bismol caplet0.14USD caplet
Soothe caplets0.12USD caplet
Bismatrol 262 mg tablet0.09USD tablet
Maalox advanced tablet chew0.09USD tablet
Maalox quick dissolve tablet0.09USD tablet
Maalox max quick dissolve tablet0.06USD tablet
Stomach relief tablet0.06USD tablet
Magnesium-aluminum suspension0.03USD ml
Bismuth 262 mg/15ml susp0.02USD ml
Maalox max strength multi symp0.02USD ml
Maalox maximum strength susp0.02USD ml
Pepto-bismol max str susp0.02USD ml
Pub calcium carb 1000 mg tablet0.02USD tablet
Maalox plus x-strength susp0.01USD ml
Maalox total relief (bismuth)0.01USD ml
DrugBank does not sell nor buy drugs. Pricing information is supplied for informational purposes only.
PatentsNot Available
Properties
StateSolid
Experimental PropertiesNot Available
Predicted Properties
PropertyValueSource
Water Solubility59.7 mg/mLALOGPS
logP0.37ALOGPS
logP1.11ChemAxon
logS-0.78ALOGPS
pKa (Strongest Acidic)14.3ChemAxon
pKa (Strongest Basic)-3.1ChemAxon
Physiological Charge0ChemAxon
Hydrogen Acceptor Count3ChemAxon
Hydrogen Donor Count1ChemAxon
Polar Surface Area55.76 Å2ChemAxon
Rotatable Bond Count0ChemAxon
Refractivity35.72 m3·mol-1ChemAxon
Polarizability15.67 Å3ChemAxon
Number of Rings2ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleYesChemAxon
Spectra
Mass Spec (NIST)Not Available
SpectraNot Available
References
Synthesis Reference

Richard William Hess, “Pigmentary bright primrose yellow monoclinic bismuth vanadate and processes for the preparation thereof.” U.S. Patent US4115142, issued December, 1925.

US4115142
General Reference
  1. Goldenberg MM, Honkomp LJ, Burrous SE, Castellion AW: Protective effect of Pepto-Bismol liquid on the gastric mucosa of rats. Gastroenterology. 1975 Sep;69(3):636-40. Pubmed
External Links
ATC CodesNot Available
AHFS Codes
  • 52:92.00
  • 56:04.00
  • 56:08.00
  • 84:92.00
  • 92:02.00*
PDB EntriesNot Available
FDA labelNot Available
MSDSDownload (73.6 KB)
Interactions
Drug Interactions
Drug
AcetazolamideThe salicylate, bismuth subsalicylate, at high dose increases the effect of the carbonic anhydrase inhibitor, acetazolamide.
AmprenavirThe antiacid decreases the absorption of amprenavir
AtazanavirThis gastric pH modifier decreases the levels/effects of atazanavir
BetamethasoneThe corticosteroid, betamethasone, may decrease the effect of the salicylate, bismuth subsalicylate.
FludrocortisoneThe corticosteroid, fludrocortisone, may decrease the effect of the salicylate, bismuth subsalicylate.
GliclazideThe salicylate, bismuth subsalicylate, increases the effect of the sulfonylurea, gliclazide.
GlyburideThe salicylate, bismuth subsalicylate, increases the effect of the sulfonylurea, glibenclamide.
HydrocortisoneThe corticosteroid, hydrocortisone, may decrease the effect of the salicylate, bismuth subsalicylate.
MethazolamideThe salicylate, bismuth subsalicylate, at high dose increases the effect of the carbonic anhydrase inhibitor, methazolamide.
MethotrexateThe salicylate, bismuth subsalicylate, increases the effect and toxicity of methotrexate.
MinocyclineFormation of non-absorbable complexes
PrednisoloneThe corticosteroid, prednisolone, may decrease the effect of the salicylate, bismuth subsalicylate.
PrednisoneThe corticosteroid, prednisone, may decrease the effect of the salicylate, bismuth subsalicylate.
ProbenecidThe salicylate, bismuth subsalicylate, decreases the uricosuric effect of probenecid.
TetracyclineFormation of non-absorbable complexes
TriamcinoloneThe corticosteroid, triamcinolone, may decrease the effect of the salicylate, bismuth subsalicylate.
Food InteractionsNot Available

Carriers

1. Serum albumin

Kind: protein

Organism: Human

Pharmacological action: unknown

Actions: binder

Components

Name UniProt ID Details
Serum albumin P02768 Details

References:

  1. Sun H, Li H, Mason AB, Woodworth RC, Sadler PJ: Competitive binding of bismuth to transferrin and albumin in aqueous solution and in blood plasma. J Biol Chem. 2001 Mar 23;276(12):8829-35. Epub 2000 Dec 7. Pubmed
  2. Sun H, Szeto KY: Binding of bismuth to serum proteins: implication for targets of Bi(III) in blood plasma. J Inorg Biochem. 2003 Feb 1;94(1-2):114-20. Pubmed
  3. Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. Pubmed

2. Serotransferrin

Kind: protein

Organism: Human

Pharmacological action: unknown

Components

Name UniProt ID Details
Serotransferrin P02787 Details

References:

  1. Sun H, Li H, Mason AB, Woodworth RC, Sadler PJ: Competitive binding of bismuth to transferrin and albumin in aqueous solution and in blood plasma. J Biol Chem. 2001 Mar 23;276(12):8829-35. Epub 2000 Dec 7. Pubmed
  2. Sun H, Szeto KY: Binding of bismuth to serum proteins: implication for targets of Bi(III) in blood plasma. J Inorg Biochem. 2003 Feb 1;94(1-2):114-20. Pubmed
  3. Zhang M, Gumerov DR, Kaltashov IA, Mason AB: Indirect detection of protein-metal binding: interaction of serum transferrin with In3+ and Bi3+. J Am Soc Mass Spectrom. 2004 Nov;15(11):1658-64. Pubmed
  4. Miquel G, Nekaa T, Kahn PH, Hemadi M, El Hage Chahine JM: Mechanism of formation of the complex between transferrin and bismuth, and interaction with transferrin receptor 1. Biochemistry. 2004 Nov 23;43(46):14722-31. Pubmed
  5. Ge R, Sun H: Bioinorganic chemistry of bismuth and antimony: target sites of metallodrugs. Acc Chem Res. 2007 Apr;40(4):267-74. Epub 2007 Mar 2. Pubmed

Comments
comments powered by Disqus
Drug created on June 30, 2007 08:17 / Updated on September 16, 2013 17:14