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Identification
NameChloral hydrate
Accession NumberDB01563
TypeSmall Molecule
GroupsApproved, Illicit, Vet Approved
DescriptionA hypnotic and sedative used in the treatment of insomnia. The safety margin is too narrow for chloral hydrate to be used as a general anesthetic in humans, but it is commonly used for that purpose in animal experiments. It is no longer considered useful as an anti-anxiety medication. [PubChem]
Structure
Thumb
SynonymsNot Available
External Identifiers Not Available
Approved Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Chloral Hydrate Capsules 500mgcapsule500 mgoralD.C. Labs Limited1968-12-312003-07-11Canada
Chloral Hydrate Syrup Odansyrup100 mgoralOdan Laboratories Ltd2003-08-06Not applicableCanada
Novo-chlorhydrate Cap 500mgcapsule500 mgoralNovopharm Limited1967-12-312005-08-10Canada
PMS-chloral Hydrate Capsules 500mgcapsule500 mgoralPharmascience Inc1996-10-10Not applicableCanada
PMS-chloral Hydrate Syrup 100mg/mlsyrup100 mgoralPharmascience Inc1990-12-31Not applicableCanada
Approved Generic Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Apo-chloral Hydrate Syrupsyrup100 mgoralApotex IncNot applicableNot applicableCanada
Approved Over the Counter ProductsNot Available
Unapproved/Other Products Not Available
International Brands
NameCompany
Aquachloral SupprettesAmerifit Pharma
SomnoteBreckenridge
Brand mixtures
NameLabellerIngredients
Analgesic BalmD.C. Labs Limited
Calmitol Itching Relief OntPfizer Canada Inc., Consumer Healthcare Division
SaltsNot Available
Categories
UNII418M5916WG
CAS number302-17-0
WeightAverage: 165.403
Monoisotopic: 163.919862461
Chemical FormulaC2H3Cl3O2
InChI KeyInChIKey=RNFNDJAIBTYOQL-UHFFFAOYSA-N
InChI
InChI=1S/C2H3Cl3O2/c3-2(4,5)1(6)7/h1,6-7H
IUPAC Name
2,2,2-trichloroethane-1,1-diol
SMILES
OC(O)C(Cl)(Cl)Cl
Taxonomy
DescriptionThis compound belongs to the class of organic compounds known as chlorohydrins. These are alcohols substituted by a chlorine atom at a saturated carbon atom otherwise bearing only hydrogen or hydrocarbyl groups.
KingdomOrganic compounds
Super ClassOrganohalogen compounds
ClassHalohydrins
Sub ClassChlorohydrins
Direct ParentChlorohydrins
Alternative Parents
Substituents
  • Chlorohydrin
  • 1,1-diol
  • Carbonyl hydrate
  • Hydrocarbon derivative
  • Organooxygen compound
  • Organochloride
  • Alkyl halide
  • Alkyl chloride
  • Aliphatic acyclic compound
Molecular FrameworkAliphatic acyclic compounds
External Descriptors
Pharmacology
IndicationMainly used as a hyponotic in the treatment of insomnia; however, it is only effective as a hypnotic for short-term use. May be used as a routine sedative preoperatively to decrease anxiety and cause sedation and/or sleep with respiration depression or cough reflex.
PharmacodynamicsNot Available
Mechanism of actionNot Available
Related Articles
AbsorptionRapidly absorbed in the GI tract following oral or rectal administration. Chloral hydrate and its active metabolite, trichloroethanol, have been detected in CSF, umbilical cord blood, fetal blood, and amniotic fluid.
Volume of distributionNot Available
Protein bindingNot Available
Metabolism

Metabolized by the liver and erythrocytes to form trichloroethanol, an active metabolite. This reaction is catalyzed by alcohol dehydrogenase and other enzymes. Oxidation of chloral hydrate and trichloroethanol to trichloroacetic acid in the liver and kidneys also occurs to a lesser extent. Trichloroethanol also undergoes glucuronidation to produce an inactive metabolism.

Route of eliminationTrichloroethanol, trichloroethanol glucuronide, and trichloroacetic acid are excreted in the urine. Some trichloroethanol glucuronide may be secreted into bile and excreted in the feces.
Half lifeNot Available
ClearanceNot Available
ToxicityNot Available
Affected organismsNot Available
PathwaysNot Available
SNP Mediated EffectsNot Available
SNP Mediated Adverse Drug ReactionsNot Available
ADMET
Predicted ADMET features
PropertyValueProbability
Human Intestinal Absorption+0.9591
Blood Brain Barrier+0.9555
Caco-2 permeable-0.5795
P-glycoprotein substrateNon-substrate0.8757
P-glycoprotein inhibitor INon-inhibitor0.9923
P-glycoprotein inhibitor IINon-inhibitor0.9794
Renal organic cation transporterNon-inhibitor0.9454
CYP450 2C9 substrateNon-substrate0.7898
CYP450 2D6 substrateNon-substrate0.9116
CYP450 3A4 substrateNon-substrate0.7558
CYP450 1A2 substrateNon-inhibitor0.7969
CYP450 2C9 inhibitorNon-inhibitor0.8017
CYP450 2D6 inhibitorNon-inhibitor0.9417
CYP450 2C19 inhibitorNon-inhibitor0.847
CYP450 3A4 inhibitorNon-inhibitor0.9446
CYP450 inhibitory promiscuityLow CYP Inhibitory Promiscuity0.9778
Ames testAMES toxic0.6454
CarcinogenicityCarcinogens 0.616
BiodegradationNot ready biodegradable0.8453
Rat acute toxicity2.5068 LD50, mol/kg Not applicable
hERG inhibition (predictor I)Weak inhibitor0.9837
hERG inhibition (predictor II)Non-inhibitor0.9558
ADMET data is predicted using admetSAR, a free tool for evaluating chemical ADMET properties. (23092397 )
Pharmacoeconomics
ManufacturersNot Available
Packagers
Dosage forms
FormRouteStrength
Ointmenttopical
Capsuleoral500 mg
Syruporal100 mg
Prices
Unit descriptionCostUnit
Pms-Chloral Hydrate 100 mg/ml Syrup0.05USD ml
DrugBank does not sell nor buy drugs. Pricing information is supplied for informational purposes only.
PatentsNot Available
Properties
StateSolid
Experimental Properties
PropertyValueSource
melting point57 °CPhysProp
boiling point98 °CPhysProp
water solubility7.93E+005 mg/L (at 25 °C)YALKOWSKY,SH & HE,Y (2003)
logP0.99HANSCH,C ET AL. (1995)
Predicted Properties
PropertyValueSource
Water Solubility43.4 mg/mLALOGPS
logP0.88ALOGPS
logP0.69ChemAxon
logS-0.58ALOGPS
pKa (Strongest Acidic)9.51ChemAxon
pKa (Strongest Basic)-5.1ChemAxon
Physiological Charge0ChemAxon
Hydrogen Acceptor Count2ChemAxon
Hydrogen Donor Count2ChemAxon
Polar Surface Area40.46 Å2ChemAxon
Rotatable Bond Count1ChemAxon
Refractivity29.25 m3·mol-1ChemAxon
Polarizability11.88 Å3ChemAxon
Number of Rings0ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleYesChemAxon
Spectra
Mass Spec (NIST)Download (8.88 KB)
Spectra
Spectrum TypeDescriptionSplash Key
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, PositiveNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, PositiveNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, PositiveNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, NegativeNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, NegativeNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, NegativeNot Available
References
Synthesis ReferenceNot Available
General ReferencesNot Available
External Links
ATC CodesN05CC01
AHFS Codes
  • 28:24.92
PDB EntriesNot Available
FDA labelNot Available
MSDSNot Available
Interactions
Drug Interactions
Drug
7-NitroindazoleThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with 7-Nitroindazole.
AcenocoumarolThe serum concentration of Acenocoumarol can be increased when it is combined with Chloral hydrate.
AcepromazineThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Acepromazine.
AceprometazineThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Aceprometazine.
adipiplonThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with adipiplon.
AgomelatineThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Agomelatine.
AlfaxaloneThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Alfaxalone.
AlfentanilThe risk or severity of adverse effects can be increased when Alfentanil is combined with Chloral hydrate.
AlphacetylmethadolThe risk or severity of adverse effects can be increased when Alphacetylmethadol is combined with Chloral hydrate.
AlprazolamThe risk or severity of adverse effects can be increased when Alprazolam is combined with Chloral hydrate.
AmisulprideThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Amisulpride.
AmitriptylineThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Amitriptyline.
AmobarbitalThe risk or severity of adverse effects can be increased when Amobarbital is combined with Chloral hydrate.
AmoxapineThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Amoxapine.
AmperozideThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Amperozide.
AripiprazoleThe risk or severity of adverse effects can be increased when Aripiprazole is combined with Chloral hydrate.
ArticaineThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Articaine.
AsenapineThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Asenapine.
AzaperoneThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Azaperone.
AzelastineChloral hydrate may increase the central nervous system depressant (CNS depressant) activities of Azelastine.
AzelastineThe risk or severity of adverse effects can be increased when Azelastine is combined with Chloral hydrate.
BaclofenThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Baclofen.
BarbitalThe risk or severity of adverse effects can be increased when Barbital is combined with Chloral hydrate.
BenzocaineThe risk or severity of adverse effects can be increased when Benzocaine is combined with Chloral hydrate.
Benzyl alcoholThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Benzyl alcohol.
BrexpiprazoleThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Brexpiprazole.
BrimonidineBrimonidine may increase the central nervous system depressant (CNS depressant) activities of Chloral hydrate.
BrimonidineThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Brimonidine.
BromazepamThe risk or severity of adverse effects can be increased when Bromazepam is combined with Chloral hydrate.
BrompheniramineThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Brompheniramine.
BrotizolamThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Brotizolam.
BupivacaineThe risk or severity of adverse effects can be increased when Bupivacaine is combined with Chloral hydrate.
BuprenorphineThe risk or severity of adverse effects can be increased when Buprenorphine is combined with Chloral hydrate.
BuspironeThe risk or severity of adverse effects can be increased when Buspirone is combined with Chloral hydrate.
ButabarbitalThe risk or severity of adverse effects can be increased when Butabarbital is combined with Chloral hydrate.
ButacaineThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Butacaine.
ButalbitalThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Butalbital.
ButambenThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Butamben.
ButethalThe risk or severity of adverse effects can be increased when Butethal is combined with Chloral hydrate.
ButorphanolThe risk or severity of adverse effects can be increased when Butorphanol is combined with Chloral hydrate.
CarbamazepineThe risk or severity of adverse effects can be increased when Carbamazepine is combined with Chloral hydrate.
CarbinoxamineThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Carbinoxamine.
CarfentanilThe risk or severity of adverse effects can be increased when Carfentanil is combined with Chloral hydrate.
CarisoprodolThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Carisoprodol.
CetirizineThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Cetirizine.
ChlordiazepoxideThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Chloral hydrate.
ChlormezanoneThe risk or severity of adverse effects can be increased when Chlormezanone is combined with Chloral hydrate.
ChloroprocaineThe risk or severity of adverse effects can be increased when Chloroprocaine is combined with Chloral hydrate.
ChlorphenamineThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Chlorphenamine.
ChlorpromazineThe risk or severity of adverse effects can be increased when Chlorpromazine is combined with Chloral hydrate.
ChlorprothixeneThe risk or severity of adverse effects can be increased when Chlorprothixene is combined with Chloral hydrate.
ChlorzoxazoneThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Chlorzoxazone.
CinchocaineThe risk or severity of adverse effects can be increased when Cinchocaine is combined with Chloral hydrate.
CitalopramThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Citalopram.
ClemastineThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Clemastine.
ClidiniumThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Clidinium.
ClobazamThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Clobazam.
clomethiazoleThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with clomethiazole.
ClomipramineThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Clomipramine.
ClonazepamThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Clonazepam.
ClonidineThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Clonidine.
ClorazepateThe risk or severity of adverse effects can be increased when Clorazepate is combined with Chloral hydrate.
ClozapineThe risk or severity of adverse effects can be increased when Clozapine is combined with Chloral hydrate.
CocaineThe risk or severity of adverse effects can be increased when Cocaine is combined with Chloral hydrate.
CodeineThe risk or severity of adverse effects can be increased when Codeine is combined with Chloral hydrate.
CyclizineThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Cyclizine.
CyclobenzaprineThe risk or severity of adverse effects can be increased when Cyclobenzaprine is combined with Chloral hydrate.
CyproheptadineThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Cyproheptadine.
DantroleneThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Dantrolene.
DapiprazoleThe risk or severity of adverse effects can be increased when Dapiprazole is combined with Chloral hydrate.
DapoxetineThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Dapoxetine.
deramciclaneThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with deramciclane.
DesfluraneThe risk or severity of adverse effects can be increased when Desflurane is combined with Chloral hydrate.
DesipramineThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Desipramine.
DesloratadineThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Desloratadine.
DetomidineThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Detomidine.
DexbrompheniramineThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Dexbrompheniramine.
DexmedetomidineThe risk or severity of adverse effects can be increased when Dexmedetomidine is combined with Chloral hydrate.
DextromoramideThe risk or severity of adverse effects can be increased when Dextromoramide is combined with Chloral hydrate.
DextropropoxypheneThe risk or severity of adverse effects can be increased when Dextropropoxyphene is combined with Chloral hydrate.
DezocineThe risk or severity of adverse effects can be increased when Dezocine is combined with Chloral hydrate.
DiazepamThe risk or severity of adverse effects can be increased when Diazepam is combined with Chloral hydrate.
DicoumarolThe serum concentration of Dicoumarol can be increased when it is combined with Chloral hydrate.
DifenoxinThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Difenoxin.
DihydrocodeineThe risk or severity of adverse effects can be increased when Dihydrocodeine is combined with Chloral hydrate.
DihydroetorphineThe risk or severity of adverse effects can be increased when Dihydroetorphine is combined with Chloral hydrate.
DihydromorphineThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Dihydromorphine.
DimenhydrinateThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Dimenhydrinate.
DiphenhydramineThe risk or severity of adverse effects can be increased when Diphenhydramine is combined with Chloral hydrate.
DiphenoxylateThe risk or severity of adverse effects can be increased when Diphenoxylate is combined with Chloral hydrate.
DoramectinThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Doramectin.
DoxepinThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Doxepin.
DoxylamineDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Chloral hydrate.
DoxylamineThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Doxylamine.
DPDPEThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with DPDPE.
DronabinolDronabinol may increase the central nervous system depressant (CNS depressant) activities of Chloral hydrate.
DroperidolThe risk or severity of adverse effects can be increased when Droperidol is combined with Chloral hydrate.
DrotebanolThe risk or severity of adverse effects can be increased when Drotebanol is combined with Chloral hydrate.
DyclonineThe risk or severity of adverse effects can be increased when Dyclonine is combined with Chloral hydrate.
EcgonineThe risk or severity of adverse effects can be increased when Ecgonine is combined with Chloral hydrate.
ECGONINE METHYL ESTERThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with ECGONINE METHYL ESTER.
EfavirenzThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Efavirenz.
EnfluraneThe risk or severity of adverse effects can be increased when Enflurane is combined with Chloral hydrate.
EntacaponeThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Entacapone.
EscitalopramThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Escitalopram.
EstazolamThe risk or severity of adverse effects can be increased when Estazolam is combined with Chloral hydrate.
EszopicloneThe risk or severity of adverse effects can be increased when Eszopiclone is combined with Chloral hydrate.
EthanolChloral hydrate may increase the central nervous system depressant (CNS depressant) activities of Ethanol.
EthanolThe risk or severity of adverse effects can be increased when Ethanol is combined with Chloral hydrate.
EthchlorvynolThe risk or severity of adverse effects can be increased when Ethchlorvynol is combined with Chloral hydrate.
EthosuximideThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Ethosuximide.
EthotoinThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Ethotoin.
Ethyl biscoumacetateThe serum concentration of Ethyl biscoumacetate can be increased when it is combined with Chloral hydrate.
Ethyl carbamateThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Ethyl carbamate.
Ethyl loflazepateThe risk or severity of adverse effects can be increased when Ethyl loflazepate is combined with Chloral hydrate.
EthylmorphineThe risk or severity of adverse effects can be increased when Ethylmorphine is combined with Chloral hydrate.
EtidocaineThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Etidocaine.
EtifoxineThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Etifoxine.
EtizolamThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Etizolam.
EtomidateThe risk or severity of adverse effects can be increased when Etomidate is combined with Chloral hydrate.
EtoperidoneThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Etoperidone.
EtorphineThe risk or severity of adverse effects can be increased when Etorphine is combined with Chloral hydrate.
EzogabineThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Ezogabine.
FelbamateThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Felbamate.
FencamfamineThe risk or severity of adverse effects can be increased when Fencamfamine is combined with Chloral hydrate.
FenfluramineThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Fenfluramine.
FentanylThe risk or severity of adverse effects can be increased when Fentanyl is combined with Chloral hydrate.
FexofenadineThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Fexofenadine.
FlibanserinThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Flibanserin.
FludiazepamThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Fludiazepam.
FlunarizineThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Flunarizine.
FlunitrazepamThe risk or severity of adverse effects can be increased when Flunitrazepam is combined with Chloral hydrate.
FluoxetineThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Fluoxetine.
FlupentixolThe risk or severity of adverse effects can be increased when Flupentixol is combined with Chloral hydrate.
FluphenazineThe risk or severity of adverse effects can be increased when Fluphenazine is combined with Chloral hydrate.
FlurazepamThe risk or severity of adverse effects can be increased when Flurazepam is combined with Chloral hydrate.
FluspirileneThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Fluspirilene.
Fluticasone PropionateThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Fluticasone Propionate.
FluvoxamineThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Fluvoxamine.
FosphenytoinThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Fosphenytoin.
FospropofolThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Fospropofol.
FurosemideThe risk or severity of adverse effects can be increased when Furosemide is combined with Chloral hydrate.
GabapentinThe risk or severity of adverse effects can be increased when Gabapentin is combined with Chloral hydrate.
gabapentin enacarbilThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with gabapentin enacarbil.
Gamma Hydroxybutyric AcidThe risk or severity of adverse effects can be increased when Gamma Hydroxybutyric Acid is combined with Chloral hydrate.
GlutethimideThe risk or severity of adverse effects can be increased when Glutethimide is combined with Chloral hydrate.
GuanfacineThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Guanfacine.
HalazepamThe risk or severity of adverse effects can be increased when Halazepam is combined with Chloral hydrate.
HaloperidolThe risk or severity of adverse effects can be increased when Haloperidol is combined with Chloral hydrate.
HalothaneThe risk or severity of adverse effects can be increased when Halothane is combined with Chloral hydrate.
HeroinThe risk or severity of adverse effects can be increased when Heroin is combined with Chloral hydrate.
HexobarbitalThe risk or severity of adverse effects can be increased when Hexobarbital is combined with Chloral hydrate.
HydrocodoneThe risk or severity of adverse effects can be increased when Hydrocodone is combined with Chloral hydrate.
HydromorphoneThe risk or severity of adverse effects can be increased when Hydromorphone is combined with Chloral hydrate.
HydroxyzineHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Chloral hydrate.
HydroxyzineThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Hydroxyzine.
IloperidoneThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Iloperidone.
ImipramineThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Imipramine.
IndalpineThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Indalpine.
IsofluraneThe risk or severity of adverse effects can be increased when Isoflurane is combined with Chloral hydrate.
KetamineThe risk or severity of adverse effects can be increased when Ketamine is combined with Chloral hydrate.
KetazolamThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Ketazolam.
KetobemidoneThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Ketobemidone.
LamotrigineThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Lamotrigine.
LevetiracetamThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Levetiracetam.
LevobupivacaineThe risk or severity of adverse effects can be increased when Levobupivacaine is combined with Chloral hydrate.
LevocabastineThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Levocabastine.
LevocetirizineThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Levocetirizine.
LevodopaThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Levodopa.
Levomethadyl AcetateThe risk or severity of adverse effects can be increased when Levomethadyl Acetate is combined with Chloral hydrate.
LevomilnacipranThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Levomilnacipran.
LevorphanolThe risk or severity of adverse effects can be increased when Levorphanol is combined with Chloral hydrate.
LidocaineThe risk or severity of adverse effects can be increased when Lidocaine is combined with Chloral hydrate.
LithiumThe risk or severity of adverse effects can be increased when Lithium is combined with Chloral hydrate.
LofentanilThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Lofentanil.
LoratadineThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Loratadine.
LorazepamThe risk or severity of adverse effects can be increased when Lorazepam is combined with Chloral hydrate.
LoxapineThe risk or severity of adverse effects can be increased when Loxapine is combined with Chloral hydrate.
Lu AA21004The risk or severity of adverse effects can be increased when Chloral hydrate is combined with Lu AA21004.
LurasidoneThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Lurasidone.
Magnesium SulfateMagnesium Sulfate may increase the central nervous system depressant (CNS depressant) activities of Chloral hydrate.
Magnesium SulfateThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Magnesium Sulfate.
MaprotilineThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Maprotiline.
MeclizineThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Meclizine.
MedetomidineThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Medetomidine.
MelatoninThe risk or severity of adverse effects can be increased when Melatonin is combined with Chloral hydrate.
MelperoneThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Melperone.
MepivacaineThe risk or severity of adverse effects can be increased when Mepivacaine is combined with Chloral hydrate.
MeprobamateThe risk or severity of adverse effects can be increased when Meprobamate is combined with Chloral hydrate.
MesoridazineThe risk or severity of adverse effects can be increased when Mesoridazine is combined with Chloral hydrate.
MetaxaloneThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Metaxalone.
MethadoneThe risk or severity of adverse effects can be increased when Methadone is combined with Chloral hydrate.
Methadyl AcetateThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Chloral hydrate.
MethapyrileneThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Methapyrilene.
MethaqualoneThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Methaqualone.
MethocarbamolThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Methocarbamol.
MethohexitalThe risk or severity of adverse effects can be increased when Methohexital is combined with Chloral hydrate.
MethotrimeprazineThe risk or severity of adverse effects can be increased when Methotrimeprazine is combined with Chloral hydrate.
MethoxyfluraneThe risk or severity of adverse effects can be increased when Methoxyflurane is combined with Chloral hydrate.
MethsuximideThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Methsuximide.
MethylphenobarbitalThe risk or severity of adverse effects can be increased when Methylphenobarbital is combined with Chloral hydrate.
MetyrosineChloral hydrate may increase the sedative activities of Metyrosine.
MidazolamThe risk or severity of adverse effects can be increased when Midazolam is combined with Chloral hydrate.
MilnacipranThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Milnacipran.
MinocyclineMinocycline may increase the central nervous system depressant (CNS depressant) activities of Chloral hydrate.
MirtazapineChloral hydrate may increase the central nervous system depressant (CNS depressant) activities of Mirtazapine.
MirtazapineThe risk or severity of adverse effects can be increased when Mirtazapine is combined with Chloral hydrate.
MolindoneThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Molindone.
MorphineThe risk or severity of adverse effects can be increased when Morphine is combined with Chloral hydrate.
NabiloneNabilone may increase the central nervous system depressant (CNS depressant) activities of Chloral hydrate.
NabiloneThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Nabilone.
NalbuphineThe risk or severity of adverse effects can be increased when Nalbuphine is combined with Chloral hydrate.
NitrazepamThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Nitrazepam.
Nitrous oxideThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Nitrous oxide.
NormethadoneThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Normethadone.
NortriptylineThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Nortriptyline.
OlanzapineThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Olanzapine.
OlopatadineThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Olopatadine.
OndansetronThe risk or severity of adverse effects can be increased when Ondansetron is combined with Chloral hydrate.
OpiumThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Opium.
OrphenadrineChloral hydrate may increase the central nervous system depressant (CNS depressant) activities of Orphenadrine.
OrphenadrineThe risk or severity of adverse effects can be increased when Orphenadrine is combined with Chloral hydrate.
OsanetantThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Osanetant.
OxazepamThe risk or severity of adverse effects can be increased when Oxazepam is combined with Chloral hydrate.
OxprenololThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Oxprenolol.
OxybuprocaineThe risk or severity of adverse effects can be increased when Oxybuprocaine is combined with Chloral hydrate.
OxycodoneThe risk or severity of adverse effects can be increased when Oxycodone is combined with Chloral hydrate.
OxymorphoneThe risk or severity of adverse effects can be increased when Oxymorphone is combined with Chloral hydrate.
PaliperidoneThe risk or severity of adverse effects can be increased when Paliperidone is combined with Chloral hydrate.
ParaldehydeChloral hydrate may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.
ParaldehydeThe risk or severity of adverse effects can be increased when Paraldehyde is combined with Chloral hydrate.
ParoxetineThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Paroxetine.
PentazocineThe risk or severity of adverse effects can be increased when Pentazocine is combined with Chloral hydrate.
PentobarbitalThe risk or severity of adverse effects can be increased when Pentobarbital is combined with Chloral hydrate.
PerampanelThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Perampanel.
PerospironeThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Perospirone.
PerphenazineThe risk or severity of adverse effects can be increased when Perphenazine is combined with Chloral hydrate.
PethidineThe risk or severity of adverse effects can be increased when Pethidine is combined with Chloral hydrate.
PhenindioneThe serum concentration of Phenindione can be increased when it is combined with Chloral hydrate.
PhenobarbitalThe risk or severity of adverse effects can be increased when Phenobarbital is combined with Chloral hydrate.
PhenoxyethanolThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Phenoxyethanol.
PhenprocoumonThe serum concentration of Phenprocoumon can be increased when it is combined with Chloral hydrate.
PhenytoinThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Phenytoin.
PimozideThe risk or severity of adverse effects can be increased when Pimozide is combined with Chloral hydrate.
PipamperoneThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Pipamperone.
PipotiazineThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Pipotiazine.
PizotifenThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Pizotifen.
PomalidomideThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Pomalidomide.
PramipexoleChloral hydrate may increase the sedative activities of Pramipexole.
PramocaineThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Pramocaine.
PrazepamThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Prazepam.
PregabalinThe risk or severity of adverse effects can be increased when Pregabalin is combined with Chloral hydrate.
PrilocaineThe risk or severity of adverse effects can be increased when Prilocaine is combined with Chloral hydrate.
PrimidoneThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Primidone.
ProcaineThe risk or severity of adverse effects can be increased when Procaine is combined with Chloral hydrate.
ProchlorperazineThe risk or severity of adverse effects can be increased when Prochlorperazine is combined with Chloral hydrate.
PromazineThe risk or severity of adverse effects can be increased when Promazine is combined with Chloral hydrate.
PromethazineThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Promethazine.
ProparacaineThe risk or severity of adverse effects can be increased when Proparacaine is combined with Chloral hydrate.
PropofolThe risk or severity of adverse effects can be increased when Propofol is combined with Chloral hydrate.
PropoxycaineThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Propoxycaine.
ProtriptylineThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Protriptyline.
PSD502The risk or severity of adverse effects can be increased when Chloral hydrate is combined with PSD502.
QuazepamThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Quazepam.
QuetiapineThe risk or severity of adverse effects can be increased when Quetiapine is combined with Chloral hydrate.
RamelteonThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Ramelteon.
RemifentanilThe risk or severity of adverse effects can be increased when Remifentanil is combined with Chloral hydrate.
RemoxiprideThe risk or severity of adverse effects can be increased when Remoxipride is combined with Chloral hydrate.
ReserpineThe risk or severity of adverse effects can be increased when Reserpine is combined with Chloral hydrate.
RisperidoneThe risk or severity of adverse effects can be increased when Risperidone is combined with Chloral hydrate.
RomifidineThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Romifidine.
RopiniroleChloral hydrate may increase the sedative activities of Ropinirole.
RopivacaineThe risk or severity of adverse effects can be increased when Ropivacaine is combined with Chloral hydrate.
RotigotineChloral hydrate may increase the sedative activities of Rotigotine.
RufinamideThe risk or severity of adverse effects can be increased when Rufinamide is combined with Chloral hydrate.
S-EthylisothioureaThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with S-Ethylisothiourea.
ScopolamineThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Scopolamine.
SecobarbitalThe risk or severity of adverse effects can be increased when Secobarbital is combined with Chloral hydrate.
SertindoleThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Sertindole.
SertralineThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Sertraline.
SevofluraneThe risk or severity of adverse effects can be increased when Sevoflurane is combined with Chloral hydrate.
Sodium oxybateThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Sodium oxybate.
StiripentolThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Stiripentol.
SufentanilThe risk or severity of adverse effects can be increased when Sufentanil is combined with Chloral hydrate.
SulpirideThe risk or severity of adverse effects can be increased when Sulpiride is combined with Chloral hydrate.
SuvorexantThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Suvorexant.
TapentadolThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Tapentadol.
TasimelteonThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Tasimelteon.
TemazepamThe risk or severity of adverse effects can be increased when Temazepam is combined with Chloral hydrate.
TetrabenazineThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Tetrabenazine.
TetracaineThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Tetracaine.
TetrodotoxinThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Tetrodotoxin.
ThalidomideChloral hydrate may increase the central nervous system depressant (CNS depressant) activities of Thalidomide.
ThalidomideThe risk or severity of adverse effects can be increased when Thalidomide is combined with Chloral hydrate.
ThiamylalThe risk or severity of adverse effects can be increased when Thiamylal is combined with Chloral hydrate.
ThiopentalThe risk or severity of adverse effects can be increased when Thiopental is combined with Chloral hydrate.
ThioridazineThe risk or severity of adverse effects can be increased when Thioridazine is combined with Chloral hydrate.
ThiothixeneThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Thiothixene.
TiagabineThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Tiagabine.
TiletamineThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Tiletamine.
TizanidineThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Tizanidine.
TolcaponeThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Tolcapone.
TopiramateThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Topiramate.
TramadolThe risk or severity of adverse effects can be increased when Tramadol is combined with Chloral hydrate.
Trans-2-PhenylcyclopropylamineThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Trans-2-Phenylcyclopropylamine.
TranylcypromineThe risk or severity of adverse effects can be increased when Tranylcypromine is combined with Chloral hydrate.
TrazodoneThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Trazodone.
TriazolamThe risk or severity of adverse effects can be increased when Triazolam is combined with Chloral hydrate.
TrifluoperazineThe risk or severity of adverse effects can be increased when Trifluoperazine is combined with Chloral hydrate.
TriflupromazineThe risk or severity of adverse effects can be increased when Triflupromazine is combined with Chloral hydrate.
TrimipramineThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Trimipramine.
TriprolidineThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Triprolidine.
Valproic AcidThe risk or severity of adverse effects can be increased when Valproic Acid is combined with Chloral hydrate.
VigabatrinThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Vigabatrin.
VilazodoneThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Vilazodone.
VortioxetineThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Vortioxetine.
WarfarinThe serum concentration of Warfarin can be increased when it is combined with Chloral hydrate.
XylazineThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Xylazine.
ZaleplonThe risk or severity of adverse effects can be increased when Zaleplon is combined with Chloral hydrate.
ZiconotideThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Ziconotide.
ZimelidineThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Zimelidine.
ZiprasidoneThe risk or severity of adverse effects can be increased when Ziprasidone is combined with Chloral hydrate.
ZolazepamThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Zolazepam.
ZolpidemThe risk or severity of adverse effects can be increased when Zolpidem is combined with Chloral hydrate.
ZonisamideThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Zonisamide.
ZopicloneThe risk or severity of adverse effects can be increased when Zopiclone is combined with Chloral hydrate.
ZotepineThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Zotepine.
ZuclopenthixolThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Zuclopenthixol.
Food InteractionsNot Available
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Drug created on July 31, 2007 07:10 / Updated on August 17, 2016 12:23