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Identification
NameDiclofenac
Accession NumberDB00586  (APRD00527)
TypeSmall Molecule
GroupsApproved
Description

A non-steroidal anti-inflammatory agent (NSAID) with antipyretic and analgesic actions. It is primarily available as the sodium salt. [PubChem]

Structure
Thumb
Synonyms
[2-(2,6-Dichloroanilino)phenyl]acetic acid
2-((2,6-Dichlorophenyl)amino)benzeneacetic acid
Diclofenac
Diclofenac Acid
Diclofenaco
Diclofenacum
ISV-205
External Identifiers Not Available
Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Ava-diclofenactablet (enteric-coated)50 mgoralAvanstra Inc2011-08-182014-08-21Canada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Ava-diclofenactablet (enteric-coated)25 mgoralAvanstra Inc2011-08-182014-08-21Canada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Ava-diclofenac SRtablet (extended-release)100 mgoralAvanstra Inc2011-09-272014-08-21Canada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Ava-diclofenac SRtablet (extended-release)75 mgoralAvanstra Inc2011-08-182014-08-21Canada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Cambiapowder, for solution1 mg/mgoralNautilus Neurosciences, Inc.2010-04-20Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Cambiapowder for solution50 mgoralTribute Pharmaceuticals Canada Inc2012-06-02Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Cambiapowder, for solution50 mg/1oralDepomed, Inc.2010-04-20Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Cataflamtablet, sugar coated50 mg/1oralNovartis Pharmaceuticals Corporation1993-11-24Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diclofenac ECtablet (enteric-coated)50 mgoralSanis Health Inc2010-06-15Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Diclofenac Ect 25mgtablet (enteric-coated)25 mgoralPro Doc Limitee1990-12-312010-07-13Canada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Diclofenac Ect 50mgtablet (enteric-coated)50 mgoralPro Doc Limitee1990-12-31Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Diclofenac Ktablet50 mgoralSanis Health Inc2010-06-15Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Diclofenac Sodiumaerosol, metered3 mg/118mLtopicalShoreline Pharmaceuticals, Inc.2016-01-07Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diclofenac Sodiumtablet, film coated, extended release100 mg/1oralSandoz Inc1996-03-08Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diclofenac Sodiumtablet, film coated, extended release100 mg/1oralPreferred Pharmaceuticals, Inc.2014-07-17Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diclofenac Sodiumtablet, film coated, extended release100 mg/1oralLake Erie Medical DBA Quality Care Products LLC1996-03-08Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diclofenac Sodiumgel30 mg/gtopicalE. Fougera & Co. a division of Fougera Pharmaceuticals Inc.2013-05-06Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diclofenac Sodiumtablet, film coated, extended release100 mg/1oralPd Rx Pharmaceuticals, Inc.1996-03-08Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diclofenac Sodiumtablet, film coated, extended release100 mg/1oralbryant ranch prepack1996-03-08Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diclofenac Sodiumtablet, film coated, extended release100 mg/1oralRx Change Co.2014-11-26Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diclofenac SRtablet (extended-release)75 mgoralSanis Health Inc2010-06-15Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Diclofenac Topical Solutionsolution1.5 %topicalSterimax Inc2015-11-23Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Diclofenac-SRtablet (extended-release)100 mgoralPro Doc Limitee1997-01-15Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Diclofenac-SRtablet (extended-release)75 mgoralPro Doc Limitee1997-08-06Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Diclotecsuppository100 mgrectalTechnilab Pharma Inc.1998-06-292004-08-03Canada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Diclotecsuppository50 mgrectalTechnilab Pharma Inc.1998-06-292004-08-03Canada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Dom-diclofenactablet50 mgoralDominion Pharmacal1998-12-17Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Dom-diclofenactablet25 mgoralDominion Pharmacal1997-12-17Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Dom-diclofenac-SRtablet (extended-release)100 mgoralDominion Pharmacal1998-03-202003-07-18Canada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Dom-diclofenac-SRtablet (extended-release)75 mgoralDominion Pharmacal1998-03-20Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Dylojectinjection, solution37.5 mg/mLintravenousHospira, Inc.2015-04-01Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Flectorpatch180 mg/1topicalSTAT Rx USA LLC2008-06-08Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Flectorpatch180 mg/1topicalRebel Distributors Corp2008-01-14Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Flectorpatch180 mg/1topicalbryant ranch prepack2008-01-14Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Flectorpatch180 mg/1topicalUnit Dose Services2008-01-14Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Flectorpatch180 mg/1topicalPfizer, Inc.2008-01-14Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Flectorpatch180 mg/1topicalRebel Distributors Corp2008-11-17Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Flectorpatch180 mg/1topicalREMEDYREPACK INC.2014-09-11Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Flectorpatch180 mg/1topicalH.J. Harkins Company, Inc.2008-01-14Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Flectorpatch180 mg/14gtopicalLake Erie Medical & Surgical Supply DBA Quality Care Products LLC2011-11-11Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Ntp-diclofenac Potassiumtablet50 mgoralTeva Canada LimitedNot applicableNot applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Ntp-diclofenac Sodiumtablet (enteric-coated)50 mgoralTeva Canada LimitedNot applicableNot applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Ntp-diclofenac Sodium SRtablet (extended-release)75 mgoralTeva Canada LimitedNot applicableNot applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Nu-diclo Enteric Coated Tab 25mgtablet (enteric-coated)25 mgoralNu Pharm Inc1990-12-312012-09-04Canada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Nu-diclo Enteric Coated Tab 50mgtablet (enteric-coated)50 mgoralNu Pharm Inc1990-12-312012-09-04Canada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Nu-diclo Rapidetablet50 mgoralNu Pharm IncNot applicableNot applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Nu-diclo SR - Srt 100mgtablet (extended-release)100 mgoralNu Pharm Inc1998-03-162012-09-04Canada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Nu-diclo SR - Srt 75mgtablet (extended-release)75 mgoralNu Pharm Inc1998-03-162012-09-04Canada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Pennsaidsolution20 mg/gtopicalMallinckrodt, Inc2012-04-27Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Pennsaidliquid16.05 mg/mLtopicalMallinckrodt, Inc2010-04-05Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Pennsaidliquid16.05 mg/mLtopicalUnit Dose Services2010-04-05Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Pennsaidsolution20 mg/gtopicalHorizon Pharma Inc.2015-01-01Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Pennsaidsolution1.5 %topicalPaladin Labs Inc2003-04-01Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Pennsaidliquid16.05 mg/mLtopicalLake Erie Medical DBA Quality Care Products LLC2010-04-05Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Pennsaidliquid16.05 mg/mLtopicalSTAT Rx USA LLC2010-04-05Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Penta-diclofenac - 25mgtablet (enteric-coated)25 mgoralPentapharm Ltd.1997-06-062004-07-30Canada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Penta-diclofenac - 50mgtablet (enteric-coated)50 mgoralPentapharm Ltd.1997-06-252004-07-30Canada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
PMS-diclofenactablet25 mgoralPharmascience Inc1997-11-28Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
PMS-diclofenactablet (delayed-release)50 mgoralPharmascience Inc2008-05-12Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
PMS-diclofenactablet (delayed-release)25 mgoralPharmascience Inc2008-05-12Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
PMS-diclofenacsuppository100 mgrectalPharmascience Inc1998-08-07Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
PMS-diclofenacsuppository50 mgrectalPharmascience Inc1998-08-07Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
PMS-diclofenacsolution1.5 %topicalPharmascience Inc2014-12-02Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
PMS-diclofenactablet50 mgoralPharmascience Inc1997-11-28Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
PMS-diclofenac Ktablet50 mgoralPharmascience Inc1999-03-04Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
PMS-diclofenac-SRtablet (extended-release)100 mgoralPharmascience Inc1997-11-28Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
PMS-diclofenac-SRtablet (extended-release)75 mgoralPharmascience Inc1997-11-28Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Pro-diclo Rapide - 50tablet50 mgoralPro Doc Limitee2008-07-07Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Rho-diclofenactablet (enteric-coated)25 mgoralRhoxalpharma IncNot applicableNot applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Rho-diclofenactablet (enteric-coated)50 mgoralRhoxalpharma IncNot applicableNot applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Riva-diclofenac 100mg SR Tabletstablet (extended-release)100 mgoralLaboratoire Riva Inc1999-08-272003-07-28Canada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Riva-diclofenac 50mg Tabletstablet (enteric-coated)50 mgoralLaboratoire Riva Inc1999-08-272003-07-28Canada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Riva-diclofenac 75mg SR Tabletstablet (extended-release)75 mgoralLaboratoire Riva Inc1999-08-272003-07-28Canada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Riva-diclofenac-K 50mg Tabletstablet50 mgoralLaboratoire Riva Inc1999-08-302003-07-28Canada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Sandoz Diclofenacsuppository100 mgrectalSandoz Canada Incorporated2000-01-212010-08-05Canada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Sandoz Diclofenacsuppository50 mgrectalSandoz Canada Incorporated2000-01-212010-08-05Canada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Sandoz-diclofenacsuppository50 mgrectalSandoz Canada Incorporated2008-10-01Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Sandoz-diclofenactablet (delayed-release)50 mgoralSandoz Canada Incorporated2006-02-02Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Sandoz-diclofenactablet (delayed-release)25 mgoralSandoz Canada Incorporated2006-02-02Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Sandoz-diclofenacsuppository100 mgrectalSandoz Canada Incorporated2008-10-01Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Sandoz-diclofenac Rapidetablet50 mgoralSandoz Canada Incorporated2006-02-02Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Sandoz-diclofenac SRtablet (extended-release)75 mgoralSandoz Canada Incorporated2006-02-02Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Sandoz-diclofenac SRtablet (extended-release)100 mgoralSandoz Canada Incorporated2006-02-02Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Solarazegel30 mg/gtopicalPharma Derm, A Division Of Fougera Pharmaceuticals Inc.2000-10-16Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Taro-diclofenacsolution1.5 %topicalTaro Pharmaceuticals Inc2014-03-31Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Taro-diclofenac Tab 25mgtablet25 mgoralTaro Pharmaceuticals Inc1993-12-312000-08-31Canada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Taro-diclofenac Tab 50mgtablet50 mgoralTaro Pharmaceuticals Inc1993-12-312000-08-31Canada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Teva-diclofenacsuppository50 mgrectalTeva Canada Limited1996-12-31Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Teva-diclofenacsuppository100 mgrectalTeva Canada Limited1996-03-15Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Teva-diclofenac ECtablet (enteric-coated)50 mgoralTeva Canada Limited1989-12-31Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Teva-diclofenac ECtablet (enteric-coated)25 mgoralTeva Canada Limited1989-12-31Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Teva-diclofenac SRtablet (extended-release)100 mgoralTeva Canada Limited1993-12-31Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Teva-diclofenac SRtablet (extended-release)75 mgoralTeva Canada Limited1995-12-31Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Teva-diclofenac-Ktablet50 mgoralTeva Canada Limited1999-01-13Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Vofenal 0.1%liquid0.1 %ophthalmicAlcon Canada Inc1998-08-282000-06-30Canada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Voltarengel10 mg/gtopicalPhysicians Total Care, Inc.2008-11-21Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Voltarengel10 mg/gtopicalLake Erie Medical & Surgical Supply DBA Quality Care Products LLC2011-11-11Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Voltarengel10 mg/gtopicalbryant ranch prepack2007-10-17Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Voltarengel10 mg/gtopicalUnit Dose Services2007-10-17Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Voltarengel10 mg/gtopicalEndo Pharmaceuticals Inc.2007-10-17Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Voltarengel10 mg/gtopicalRebel Distributors Corp2007-10-17Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Voltarengel10 mg/gtopicalProficient Rx LP2007-10-17Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Voltarengel10 mg/gtopicalDIRECT RX2015-01-01Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Voltarengel10 mg/gtopicalSTAT Rx USA LLC2007-10-17Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Voltarengel10 mg/gtopicalPreferred Pharmaceuticals, Inc.2014-10-08Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Voltarensolution1 mg/mLophthalmicNovartis Pharmaceutical Corporation1991-03-28Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Voltarengel10 mg/gtopicalKeltman Pharmaceuticals Inc.2011-01-27Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Voltarengel10 mg/gtopicalClinical Solutions Wholesale2007-10-17Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Voltarengel10 mg/gtopicalSTAT Rx USA LLC2007-10-17Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Voltarengel10 mg/gtopicalREMEDYREPACK INC.2014-06-16Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Voltaren Ophthasolution0.1 %ophthalmicAlcon Canada Inc1991-12-31Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Voltaren Rapide Tablets 50mgtablet50 mgoralNovartis Pharmaceuticals Canada Inc1993-12-31Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Voltaren SR 75 Tabtablet (extended-release)75 mgoralNovartis Pharmaceuticals Canada Inc1989-12-31Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Voltaren SR Tab 100mgtablet (extended-release)100 mgoralNovartis Pharmaceuticals Canada Inc1985-12-31Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Voltaren Sup 100mgsuppository100 mgrectalNovartis Pharmaceuticals Canada Inc1985-12-31Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Voltaren Sup 50mgsuppository50 mgrectalNovartis Pharmaceuticals Canada Inc1985-12-31Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Voltaren Tab 25mgtablet (delayed-release)25 mgoralNovartis Pharmaceuticals Canada Inc1980-12-312003-10-09Canada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Voltaren Tab 50mgtablet (delayed-release)50 mgoralNovartis Pharmaceuticals Canada Inc1980-12-31Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Voltaren XRtablet, film coated, extended release100 mg/1oralNovartis Pharmaceuticals Corporation1996-03-08Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Zipsorcapsule, liquid filled25 mg/1oralDepomed, Inc.2009-06-16Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Zipsorcapsule, liquid filled25 mg/1oralPd Rx Pharmaceuticals, Inc.2010-04-30Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Zipsorcapsule, liquid filled25 mg/1oralLake Erie Medical DBA Quality Care Products2010-12-22Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Zorvolexcapsule35 mg/1oralIroko Pharmaceuticals LLC2013-10-31Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Zorvolexcapsule18 mg/1oralIroko Pharmaceuticals LLC2013-10-31Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Generic Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Apo-diclotablet (enteric-coated)50 mgoralApotex Inc1989-12-31Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Apo-diclotablet (enteric-coated)25 mgoralApotex Inc1989-12-31Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Apo-diclo Rapide 50 Mg Tabletstablet50 mgoralApotex Inc2001-05-25Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Apo-diclo SRtablet (extended-release)100 mgoralApotex Inc1994-12-31Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Apo-diclo SRtablet (extended-release)75 mgoralApotex Inc1995-12-31Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Apo-diclofenacsolution1.5 %topicalApotex IncNot applicableNot applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Apo-diclofenac Ophthalmicsolution0.1 %ophthalmicApotex Inc2015-09-01Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Diclofenacsolution/ drops1 mg/mLophthalmicAkorn, Inc.2008-05-01Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diclofenacsolution/ drops1 mg/mLophthalmicAltaire Pharmaceuticals Inc.2015-11-16Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diclofenacsolution/ drops1 mg/mLophthalmicLake Erie Medical DBA Quality Care Products LLC2008-05-01Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diclofenac Potassiumtablet, film coated50 mg/1oralPhysicians Total Care, Inc.2008-10-15Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diclofenac Potassiumtablet, film coated50 mg/1oralCarilion Materials Management1998-08-11Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diclofenac Potassiumtablet, film coated50 mg/1oralTeva Pharmaceuticals USA Inc1998-08-11Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diclofenac Potassiumtablet, film coated50 mg/1oralDIRECT RX2014-01-01Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diclofenac Potassiumtablet, film coated50 mg/1oralMylan Pharmaceuticals Inc.2012-08-13Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diclofenac Potassiumtablet, film coated50 mg/1oralAidarex Pharmaceuticals LLC1998-08-11Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diclofenac Potassiumtablet, film coated50 mg/1oralPd Rx Pharmaceuticals, Inc.1998-11-20Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diclofenac Potassiumtablet, film coated50 mg/1oralREMEDYREPACK INC.2015-09-04Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diclofenac Potassiumtablet, film coated50 mg/1oralRebel Distributors Corp2010-01-21Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diclofenac Potassiumtablet50 mg/1oralREMEDYREPACK INC.2012-03-30Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diclofenac Potassiumtablet, film coated50 mg/1oralbryant ranch prepack2010-01-21Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diclofenac Potassiumtablet, film coated50 mg/1oralH.J. Harkins Company, Inc.2010-01-21Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diclofenac Potassiumtablet50 mg/1oralApotheca, Inc2007-08-20Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diclofenac Potassiumtablet, film coated50 mg/1oralLake Erie Medical DBA Quality Care Products LLC1998-08-11Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diclofenac Potassiumtablet, film coated50 mg/1oralClinical Solutions Wholesale1998-11-20Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diclofenac Potassiumtablet, film coated50 mg/1oralSandoz Inc1998-11-20Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diclofenac Potassiumtablet, film coated50 mg/1oralLake Erie Medical & Surgical Supply DBA Quality Care Products LLC2011-12-05Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diclofenac Potassiumtablet, film coated50 mg/1oralStat Rx USA2004-03-18Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diclofenac Sodiumtablet, delayed release75 mg/1oralUnit Dose Services2008-08-19Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diclofenac Sodiumtablet, delayed release75 mg/1oralSTAT Rx USA LLC2010-03-05Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diclofenac Sodiumtablet, film coated, extended release100 mg/1oralProficient Rx LP2002-11-06Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diclofenac Sodiumtablet, delayed release75 mg/1oralSandoz Inc1995-11-30Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diclofenac Sodiumtablet, delayed release75 mg/1oralDispensing Solutions, Inc.2008-08-19Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diclofenac Sodiumtablet, delayed release25 mg/1oralClinical Solutions Wholesale2010-12-31Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diclofenac Sodiumtablet, film coated, extended release100 mg/1oralPreferred Pharmaceuticals, Inc.2014-06-02Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diclofenac Sodiumtablet, film coated, extended release100 mg/1oralBlenheim Pharmacal, Inc.2015-06-02Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diclofenac Sodiumtablet, delayed release50 mg/1oralBlue Point Laboratories2015-12-21Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diclofenac Sodiumtablet, delayed release50 mg/1oralGolden State Medical Supply, Inc.2015-07-27Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diclofenac Sodiumtablet, delayed release75 mg/1oralProficient Rx LP2008-08-19Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diclofenac Sodiumtablet, delayed release25 mg/1oralRising Pharmaceuticals, Inc.2010-12-31Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diclofenac Sodiumtablet, delayed release75 mg/1oralNcs Health Care Of Ky, Inc Dba Vangard Labs1996-03-26Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diclofenac Sodiumtablet, delayed release75 mg/1oralPhysicians Total Care, Inc.1997-02-10Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diclofenac Sodiumtablet, delayed release50 mg/1oralDispensing Solutions, Inc.1996-03-26Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diclofenac Sodiumtablet, delayed release75 mg/1oralPreferred Pharmaceuticals, Inc.2008-08-19Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diclofenac Sodiumtablet, delayed release50 mg/1oralBlenheim Pharmacal, Inc.2015-05-18Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diclofenac Sodiumtablet, film coated, extended release100 mg/1oralMylan Pharmaceuticals Inc.2002-02-15Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diclofenac Sodiumsolution/ drops1 mg/mLophthalmicBausch & Lomb Incorporated2007-12-28Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diclofenac Sodiumsolution16.05 mg/mLtopicalTaro Pharmaceuticals U.S.A., Inc.2014-11-26Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diclofenac Sodiumsolution16.05 mg/mLtopicalPharmaceutica North America, Inc2015-08-13Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diclofenac Sodiumtablet, delayed release25 mg/1oralBlue Point Laboratories2015-12-21Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diclofenac Sodiumtablet, film coated, extended release100 mg/1oralDIRECT RX2014-01-01Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diclofenac Sodiumtablet, delayed release50 mg/1oralRising Pharmaceuticals, Inc.2010-12-31Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diclofenac Sodiumtablet, delayed release50 mg/1oralNcs Health Care Of Ky, Inc Dba Vangard Labs1996-03-26Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diclofenac Sodiumtablet, delayed release75 mg/1oralRebel Distributors Corp2008-08-19Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diclofenac Sodiumtablet, delayed release50 mg/1oralPhysicians Total Care, Inc.1995-11-16Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diclofenac Sodiumtablet, delayed release75 mg/1oralMc Kesson Packaging Services A Business Unit Of Mc Kesson Corporation2011-07-01Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diclofenac Sodiumtablet, delayed release50 mg/1oralPd Rx Pharmaceuticals, Inc.1995-09-28Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diclofenac Sodiumtablet, delayed release50 mg/1oralPreferred Pharmaceuticals, Inc.2010-05-18Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diclofenac Sodiumtablet, delayed release75 mg/1oralBlenheim Pharmacal, Inc2015-05-27Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diclofenac Sodiumtablet, film coated, extended release100 mg/1oralActavis Elizabeth LLC2002-01-09Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diclofenac Sodiumtablet, delayed release50 mg/1oralAphena Pharma Solutions Tennessee, Inc.1998-11-13Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diclofenac Sodiumtablet, delayed release50 mg/1oralDIRECT RX2015-12-22Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diclofenac Sodiumtablet, delayed release75 mg/1oralRising Pharmaceuticals, Inc.2008-08-19Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diclofenac Sodiumsolution16.05 mg/mLtopicalActavis Pharma, Inc.2015-04-06Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diclofenac Sodiumtablet, film coated, extended release100 mg/1oralLake Erie Medical DBA Quality Care Products LLC2002-01-09Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diclofenac Sodiumsolution/ drops1 mg/mLophthalmicH.J. Harkins Company, Inc.2007-12-28Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diclofenac Sodiumtablet, delayed release25 mg/1oralBlue Point Laboratories2014-02-24Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diclofenac Sodiumtablet, delayed release75 mg/1oralPd Rx Pharmaceuticals, Inc.1996-03-26Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diclofenac Sodiumtablet, delayed release50 mg/1oralPreferred Pharmaceuticals, Inc.2010-12-31Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diclofenac Sodiumtablet, delayed release75 mg/1oralActavis Pharma, Inc.1996-03-26Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diclofenac Sodiumsolution/ drops1 mg/mLophthalmicRebel Distributors Corp2007-12-28Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diclofenac Sodiumtablet, delayed release50 mg/1oralMylan Institutional Inc.2010-06-04Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diclofenac Sodiumtablet, delayed release50 mg/1oralPd Rx Pharmaceuticals, Inc.1996-03-26Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diclofenac Sodiumsolution16.05 mg/mLtopicalNovel Laboratories, Inc.2015-12-09Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diclofenac Sodiumsolution/ drops3.5 mg/mLophthalmicPACK Pharmaceuticals, LLC2008-06-20Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diclofenac Sodiumtablet, film coated, extended release100 mg/1oralActavis Pharma, Inc.2002-11-06Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diclofenac Sodiumtablet, delayed release50 mg/1oralLake Erie Medical DBA Quality Care Products LLC2010-12-31Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diclofenac Sodiumtablet, extended release100 mg/1oralREMEDYREPACK INC.2012-03-28Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diclofenac Sodiumtablet, delayed release50 mg/1oralBlue Point Laboratories2014-02-24Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diclofenac Sodiumtablet, delayed release50 mg/1oralActavis Pharma, Inc.1996-03-26Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diclofenac Sodiumtablet, delayed release75 mg/1oralMylan Institutional Inc.2010-06-04Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diclofenac Sodiumtablet, delayed release50 mg/1oralPd Rx Pharmaceuticals, Inc.1996-03-26Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diclofenac Sodiumtablet, extended release100 mg/1oralbryant ranch prepack2004-03-02Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diclofenac Sodiumsolution16.05 mg/mLtopicalInternational Brand Management, Llc2016-02-04Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diclofenac Sodiumtablet, delayed release75 mg/1oralCardinal Health1995-11-30Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diclofenac Sodiumsolution16.05 mg/mLtopicalPaddock Laboratories, LLC2014-11-24Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diclofenac Sodiumtablet, delayed release75 mg/1oralLake Erie Medical DBA Quality Care Products LLC2008-08-19Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diclofenac Sodiumtablet, delayed release75 mg/1oralH.J. Harkins Company, Inc.2008-08-19Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diclofenac Sodiumtablet, delayed release50 mg/1oralREMEDYREPACK INC.2012-03-27Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diclofenac Sodiumtablet, delayed release75 mg/1oralBlue Point Laboratories2014-02-24Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diclofenac Sodiumsolution16.05 mg/mLtopicalPure Tek Corporation2015-11-04Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diclofenac Sodiumtablet, film coated, extended release100 mg/1oralDIRECT RX2015-01-01Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diclofenac Sodiumtablet, delayed release75 mg/1oralKeltman Pharmaceuticals Inc.2009-07-01Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diclofenac Sodiumtablet, delayed release50 mg/1oralBlenheim Pharmacal, Inc2013-03-28Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diclofenac Sodiumgel30 mg/gtopicalImpax Generics2013-11-21Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diclofenac Sodiumtablet, delayed release75 mg/1oralRebel Distributors Corp1996-03-26Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diclofenac Sodiumtablet, film coated, extended release100 mg/1oralPd Rx Pharmaceuticals, Inc.2010-01-27Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diclofenac Sodiumtablet, delayed release75 mg/1oralbryant ranch prepack1996-03-26Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diclofenac Sodiumtablet, film coated, extended release100 mg/1oralOceanside Pharmaceuticals2000-02-28Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diclofenac Sodiumsolution/ drops1 mg/mLophthalmicPhysicians Total Care, Inc.2011-07-19Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diclofenac Sodiumsolution1 mg/mLophthalmicSandoz Inc2008-02-14Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diclofenac Sodiumsolution16.05 mg/mLtopicalTeligent Pharma, Inc.2015-07-08Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diclofenac Sodiumtablet, delayed release75 mg/1oralREMEDYREPACK INC.2012-03-02Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diclofenac Sodiumtablet, delayed release75 mg/1oralAphena Pharma Solutions Tennessee, Inc.1996-03-26Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diclofenac Sodiumtablet, film coated, extended release100 mg/1oralPreferred Pharmaceuticals, Inc.2012-06-04Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diclofenac Sodiumtablet, delayed release50 mg/1oralBlenheim Pharmacal, Inc.2015-07-15Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diclofenac Sodiumtablet, delayed release75 mg/1oralMylan Pharmaceuticals Inc.2010-05-18Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diclofenac Sodiumtablet, extended release100 mg/1oralPhysicians Total Care, Inc.2004-03-02Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diclofenac Sodiumtablet, delayed release50 mg/1oralUnit Dose Services1995-09-28Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diclofenac Sodiumtablet, delayed release75 mg/1oralAmerican Health Packaging2009-04-02Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diclofenac Sodiumsolution16.05 mg/mLtopicalApotex Corp.2014-05-28Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diclofenac Sodiumtablet, delayed release50 mg/1oralStat Rx USA1995-09-28Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diclofenac Sodiumtablet, delayed release50 mg/1oralSandoz Inc1995-09-28Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diclofenac Sodiumtablet, delayed release75 mg/1oralAv Kare, Inc.1998-11-13Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diclofenac Sodiumtablet, delayed release50 mg/1oralRebel Distributors Corp1996-03-26Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diclofenac Sodiumtablet, delayed release50 mg/1oralSTAT Rx USA LLC2010-03-05Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diclofenac Sodiumtablet, delayed release50 mg/1oralProficient Rx LP1996-03-26Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diclofenac Sodiumtablet, delayed release50 mg/1oralSt Marys Medical Park Pharmacy2014-04-21Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diclofenac Sodiumtablet, delayed release25 mg/1oralCarilion Materials Management1995-09-28Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diclofenac Sodiumtablet, film coated, extended release100 mg/1oralTEVA Pharmaceuticals USA Inc.2000-02-28Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diclofenac Sodiumtablet, delayed release75 mg/1oralREMEDYREPACK INC.2011-06-02Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diclofenac Sodiumtablet, delayed release50 mg/1oralAphena Pharma Solutions Tennessee, Inc.1996-03-26Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diclofenac Sodiumtablet, delayed release50 mg/1oralClinical Solutions Wholesale2010-12-31Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diclofenac Sodiumtablet, film coated, extended release100 mg/1oralPreferred Pharmaceuticals, Inc.2014-02-03Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diclofenac Sodiumtablet, delayed release75 mg/1oralBlenheim Pharmacal, Inc.2008-08-19Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diclofenac Sodiumtablet, delayed release50 mg/1oralMylan Pharmaceuticals Inc.2010-05-18Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diclofenac Sodiumtablet, delayed release25 mg/1oralPhysicians Total Care, Inc.2004-05-21Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diclofenac Sodiumtablet, delayed release75 mg/1oralBlue Point Laboratories2015-12-21Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diclofenac Sodiumtablet, delayed release75 mg/1oralGolden State Medical Supply, Inc.2015-07-27Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diclofenac Sodiumtablet, film coated, extended release100 mg/1oralProficient Rx LP1996-03-08Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diclofenac Sodiumtablet, delayed release25 mg/1oralSandoz Inc1995-09-28Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diclofenac Sodiumtablet, delayed release50 mg/1oralAv Kare, Inc.1998-11-13Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diclofenac Sodium D/rtablet, delayed release75 mg/1oralDIRECT RX2014-01-01Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diclofenac Sodium D/rtablet, delayed release50 mg/1oralDIRECT RX2014-01-01Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diclofenac Sodium Delayed Releasetablet, delayed release50 mg/1oralRebel Distributors Corp2012-04-10Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diclofenac Sodium Delayed Releasetablet, delayed release50 mg/1oralLake Erie Medical & Surgical Supply DBA Quality Care Products LLC2012-04-10Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diclofenac Sodium Delayed Releasetablet, delayed release75 mg/1oralGolden State Medical Supply, Inc.2014-08-12Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diclofenac Sodium Delayed Releasetablet, delayed release75 mg/1oralLake Erie Medical & Surgical Supply DBA Quality Care Products LLC2012-04-10Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diclofenac Sodium Delayed Releasetablet, delayed release75 mg/1oralCarlsbad Technology, Inc.1998-11-13Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diclofenac Sodium Delayed Releasetablet, delayed release50 mg/1oralGolden State Medical Supply, Inc.2014-08-12Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diclofenac Sodium Delayed Releasetablet, delayed release50 mg/1oralCarlsbad Technology, Inc.1998-11-13Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diclofenac Sodium Delayed Releasetablet, delayed release75 mg/1oralBlenheim Pharmacal, Inc.2013-09-30Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diclofenac Sodium Delayed Releasetablet, delayed release25 mg/1oralCarlsbad Technology, Inc.1998-11-13Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diclofenac Sodium Delayed Releasetablet, delayed release50 mg/1oralPreferred Pharmaceuticals Inc.2015-11-20Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diclofenac Sodium Delayed Releasetablet, delayed release50 mg/1oralBlenheim Pharmacal, Inc.2013-11-30Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diclofenac Sodium Delayed Releasetablet, delayed release75 mg/1oralPreferred Pharmaceuticals Inc.2015-08-31Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diclofenac Sodium Delayed Releasetablet, delayed release75 mg/1oralProficient Rx LP1998-11-13Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diclofenac Sodium Delayed Release Delayed Releasetablet, delayed release75 mg/1oralREMEDYREPACK INC.2013-06-04Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diclofenac Sodium Delayed Release Delayed Releasetablet, delayed release75 mg/1oralREMEDYREPACK INC.2013-06-24Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diclofenac Sodium Drtablet, delayed release50 mg/1oralNorthwind Pharmaceuticals2015-01-16Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diclofenac Sodium Extended-releasetablet, extended release100 mg/1oralSt Marys Medical Park Pharmacy2002-01-07Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diclofenac Sodium Extended-releasetablet, extended release100 mg/1oralMedsource Pharmaceuticals2009-01-05Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diclofenac Sodium Extended-releasetablet, extended release100 mg/1oralRebel Distributors Corp.2002-01-07Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diclofenac Sodium Extended-releasetablet, extended release100 mg/1oralUnit Dose Services2002-01-07Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Diclofenac Sodium Topical Solution 1.5%solution19.26 mg/1.2mLtopicalSircle Laboratories, Llc2015-07-08Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Flectorpatch180 mg/1topicalDIRECT RX2014-01-01Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Flectorpatch180 mg/1topicalPhysicians Total Care, Inc.2008-11-17Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Over the Counter ProductsNot Available
International Brands
NameCompany
AclonacNot Available
AllvoranNot Available
EcofenacNot Available
EffektonNot Available
Nu-DicloNot Available
PrimofenacNot Available
ProphenatinNot Available
RhumalganNot Available
Voltaren EmulgelNot Available
VoltarolNot Available
Brand mixtures
NameLabellerIngredients
Act Diclo-misoActavis Pharma Company
ArthrotecG.D. Searle LLC Division of Pfizer Inc
Arthrotec 50Pfizer Canada Inc
Arthrotec 75Pfizer Canada Inc
Diclofenac MisoprostolAbri Pharmaceuticals Inc
Diclofenac Sodium and MisoprostolActavis Pharma, Inc.
Diclofenac Sodium and Misoprostol Delayed-releaseEagle Pharmaceuticals, Inc.
Dipentocaine Topical Cream Compounding KitAlvix Laboratories, LLC
Gd-diclofenac/misoprostol 50Genmed A Division Of Pfizer Canada Inc
Gd-diclofenac/misoprostol 75Genmed A Division Of Pfizer Canada Inc
PMS-diclofenac-misoprostolPharmascience Inc
Sandoz Diclofenac MisoprostolSandoz Canada Incorporated
Salts
Name/CASStructureProperties
Diclofenac epolamine
ThumbNot applicableDBSALT001398
Diclofenac potassium
ThumbNot applicableDBSALT000864
Diclofenac sodium
15307-79-6
Thumb
  • InChI Key: KPHWPUGNDIVLNH-UHFFFAOYSA-M
  • Monoisotopic Mass: 316.998628658
  • Average Mass: 318.13
DBSALT000466
Categories
UNII144O8QL0L1
CAS number15307-86-5
WeightAverage: 296.149
Monoisotopic: 295.016684015
Chemical FormulaC14H11Cl2NO2
InChI KeyInChIKey=DCOPUUMXTXDBNB-UHFFFAOYSA-N
InChI
InChI=1S/C14H11Cl2NO2/c15-10-5-3-6-11(16)14(10)17-12-7-2-1-4-9(12)8-13(18)19/h1-7,17H,8H2,(H,18,19)
IUPAC Name
2-{2-[(2,6-dichlorophenyl)amino]phenyl}acetic acid
SMILES
OC(=O)CC1=CC=CC=C1NC1=C(Cl)C=CC=C1Cl
Taxonomy
DescriptionThis compound belongs to the class of organic compounds known as phenylacetic acid derivatives. These are compounds containing a phenylacetic acid moiety, which consists of a phenyl group substituted at the second position by an acetic acid.
KingdomOrganic compounds
Super ClassBenzenoids
ClassBenzene and substituted derivatives
Sub ClassPhenylacetic acid derivatives
Direct ParentPhenylacetic acid derivatives
Alternative Parents
Substituents
  • Phenylacetate
  • Substituted aniline
  • 1,3-dichlorobenzene
  • Halobenzene
  • Chlorobenzene
  • Aniline
  • Aryl halide
  • Aryl chloride
  • Secondary amine
  • Monocarboxylic acid or derivatives
  • Carboxylic acid
  • Carboxylic acid derivative
  • Hydrocarbon derivative
  • Organooxygen compound
  • Organonitrogen compound
  • Organochloride
  • Organohalogen compound
  • Carbonyl group
  • Amine
  • Aromatic homomonocyclic compound
Molecular FrameworkAromatic homomonocyclic compounds
External Descriptors
Pharmacology
IndicationFor the acute and chronic treatment of signs and symptoms of osteoarthritis and rheumatoid arthritis.
PharmacodynamicsDiclofenac is an acetic acid nonsteroidal antiinflammatory drug (NSAID) with analgesic and antipyretic properties. Diclofenac is used to treat pain, dysmenorrhea, ocular inflammation, osteoarthritis, rheumatoid arthritis, ankylosing spondylitis, and actinic keratosis
Mechanism of actionThe antiinflammatory effects of diclofenac are believed to be due to inhibition of both leukocyte migration and the enzyme cylooxygenase (COX-1 and COX-2), leading to the peripheral inhibition of prostaglandin synthesis. As prostaglandins sensitize pain receptors, inhibition of their synthesis is responsible for the analgesic effects of diclofenac. Antipyretic effects may be due to action on the hypothalamus, resulting in peripheral dilation, increased cutaneous blood flow, and subsequent heat dissipation.
AbsorptionCompletely absorbed from the gastrointestinal tract.
Volume of distribution
  • 1.3 L/kg
Protein bindingMore than 99%
Metabolism

Hepatic

SubstrateEnzymesProduct
Diclofenac
4'-HydroxydiclofenacDetails
Diclofenac
Diclofenac acyl glucuronideDetails
Diclofenac
3'-HydroxydiclofenacDetails
Diclofenac
5-HydroxydiclofenacDetails
4'-Hydroxydiclofenac
Not Available
4',5-DihydroxydiclofenacDetails
5-Hydroxydiclofenac
Not Available
4',5-DihydroxydiclofenacDetails
Route of eliminationDiclofenac is eliminated through metabolism and subsequent urinary and biliary excretion of the glucuronide and the sulfate conjugates of the metabolites. Little or no free unchanged diclofenac is excreted in the urine. Approximately 65% of the dose is excreted in the urine and approximately 35% in the bile as conjugates of unchanged diclofenac plus metabolites.
Half life2 hours
Clearance
  • oral cl=622 mL/min [healthy]
  • renal cl <1 mL/min [healthy]
ToxicitySymptoms of overdose include loss of consciousness, increased intracranial pressure, and aspiration pneumonitis. LD50=390mg/kg (orally in mice)
Affected organisms
  • Humans and other mammals
PathwaysNot Available
SNP Mediated EffectsNot Available
SNP Mediated Adverse Drug ReactionsNot Available
ADMET
Predicted ADMET features
PropertyValueProbability
Human Intestinal Absorption+0.9548
Blood Brain Barrier+0.9541
Caco-2 permeable+0.8867
P-glycoprotein substrateNon-substrate0.7976
P-glycoprotein inhibitor INon-inhibitor0.8254
P-glycoprotein inhibitor IINon-inhibitor0.9548
Renal organic cation transporterNon-inhibitor0.9086
CYP450 2C9 substrateNon-substrate0.7779
CYP450 2D6 substrateNon-substrate0.9116
CYP450 3A4 substrateNon-substrate0.6724
CYP450 1A2 substrateInhibitor0.5923
CYP450 2C9 inhibitorInhibitor0.6786
CYP450 2D6 inhibitorNon-inhibitor0.848
CYP450 2C19 inhibitorNon-inhibitor0.8947
CYP450 3A4 inhibitorNon-inhibitor0.8647
CYP450 inhibitory promiscuityLow CYP Inhibitory Promiscuity0.6607
Ames testNon AMES toxic0.9133
CarcinogenicityNon-carcinogens0.6706
BiodegradationNot ready biodegradable0.9719
Rat acute toxicity3.6447 LD50, mol/kg Not applicable
hERG inhibition (predictor I)Weak inhibitor0.9514
hERG inhibition (predictor II)Non-inhibitor0.868
ADMET data is predicted using admetSAR, a free tool for evaluating chemical ADMET properties. (23092397 )
Pharmacoeconomics
Manufacturers
  • Institut biochemique sa
  • Xanodyne pharmaceutics inc
  • Nautilus neurosciences inc
  • Novartis pharmaceuticals corp
  • Apotex inc
  • Mutual pharmaceutical co inc
  • Mylan pharmaceuticals inc
  • Sandoz inc
  • Teva pharmaceuticals usa inc
  • Watson laboratories inc
  • Nycomed us inc
  • Novartis consumer health inc
  • Akorn inc
  • Alcon inc
  • Apotex inc richmond hill
  • Bausch and lomb inc
  • Falcon pharmaceuticals ltd
  • Nexus pharmaceuticals inc
  • Mallinckrodt inc
  • Actavis elizabeth llc
  • Alphapharm party ltd
  • Carlsbad technology inc
  • Nostrum laboratories inc
  • Pliva inc
  • Roxane laboratories inc
  • Teva pharmaceuticals usa
  • Unique pharmaceutical laboratories
  • Biovail laboratories inc
  • Dexcel ltd
Packagers
Dosage forms
FormRouteStrength
Tablet (enteric-coated)oral
Tablet (enteric-coated)oral25 mg
Tablet (enteric-coated)oral50 mg
Tablet, film coatedoral
Tabletoral
Powder for solutionoral50 mg
Powder, for solutionoral1 mg/mg
Powder, for solutionoral50 mg/1
Tablet, sugar coatedoral50 mg/1
Solution/ dropsophthalmic1 mg/mL
Tabletoral50 mg/1
Tablet, film coatedoral50 mg/1
Aerosol, meteredtopical3 mg/118mL
Geltopical30 mg/g
Solutiontopical16.05 mg/mL
Solution/ dropsophthalmic3.5 mg/mL
Tablet, delayed releaseoral25 mg/1
Tablet, delayed releaseoral50 mg/1
Tablet, delayed releaseoral75 mg/1
Tablet, delayed releaseoral
Tablet, extended releaseoral100 mg/1
Solutiontopical19.26 mg/1.2mL
Kittopical
Injection, solutionintravenous37.5 mg/mL
Patchtopical180 mg/1
Patchtopical180 mg/14g
Liquidtopical16.05 mg/mL
Solutiontopical1.5 %
Solutiontopical20 mg/g
Tabletoral25 mg
Tablet (delayed-release)oral25 mg
Suppositoryrectal100 mg
Suppositoryrectal50 mg
Tablet (extended-release)oral100 mg
Tablet (extended-release)oral75 mg
Liquidophthalmic0.1 %
Geltopical10 mg/g
Solutionophthalmic1 mg/mL
Solutionophthalmic0.1 %
Tabletoral50 mg
Tablet (delayed-release)oral50 mg
Tablet, film coated, extended releaseoral100 mg/1
Capsule, liquid filledoral25 mg/1
Capsuleoral18 mg/1
Capsuleoral35 mg/1
Prices
Unit descriptionCostUnit
Voltaren Ophtha 0.1 % Solution2.73USD ml
Voltaren 100 mg Suppository1.88USD suppository
Voltaren Sr 100 mg Sustained-Release Tablet1.86USD tablet
Voltaren 50 mg Suppository1.4USD suppository
Voltaren Sr 75 mg Sustained-Release Tablet1.31USD tablet
Voltaren 50 mg Enteric-Coated Tablet0.93USD tablet
Pms-Diclofenac 100 mg Suppository0.88USD suppository
Sandoz Diclofenac 100 mg Suppository0.88USD suppository
Novo-Difenac Sr 100 mg Sustained-Release Tablet0.8USD tablet
Pms-Diclofenac-Sr 100 mg Sustained-Release Tablet0.8USD tablet
Sandoz Diclofenac Sr 100 mg Sustained-Release Tablet0.8USD tablet
Pms-Diclofenac 50 mg Suppository0.65USD suppository
Sandoz Diclofenac 50 mg Suppository0.65USD suppository
Novo-Difenac Sr 75 mg Sustained-Release Tablet0.6USD tablet
Pms-Diclofenac-Sr 75 mg Sustained-Release Tablet0.6USD tablet
Sandoz Diclofenac Sr 75 mg Sustained-Release Tablet0.6USD tablet
Apo-Diclo 50 mg Enteric-Coated Tablet0.4USD tablet
Novo-Difenac 50 mg Enteric-Coated Tablet0.4USD tablet
Pms-Diclofenac 50 mg Enteric-Coated Tablet0.4USD tablet
Sandoz Diclofenac 50 mg Enteric-Coated Tablet0.4USD tablet
Apo-Diclo 25 mg Enteric-Coated Tablet0.2USD tablet
Novo-Difenac 25 mg Enteric-Coated Tablet0.2USD tablet
Nu-Diclo 25 mg Enteric-Coated Tablet0.2USD tablet
Pms-Diclofenac 25 mg Enteric-Coated Tablet0.2USD tablet
Sandoz Diclofenac 25 mg Enteric-Coated Tablet0.2USD tablet
DrugBank does not sell nor buy drugs. Pricing information is supplied for informational purposes only.
Patents
CountryPatent NumberApprovedExpires (estimated)
United States56076901994-04-132014-04-13
United States76628582009-02-242029-02-24
Properties
StateSolid
Experimental Properties
PropertyValueSource
melting point283-285 °CNot Available
water solubility2.37 mg/L (at 25 °C)FINI,A ET AL. (1986)
logP4.51AVDEEF,A (1997)
pKa4.15SANGSTER (1994)
Predicted Properties
PropertyValueSource
Water Solubility0.00447 mg/mLALOGPS
logP4.98ALOGPS
logP4.26ChemAxon
logS-4.8ALOGPS
pKa (Strongest Acidic)4ChemAxon
pKa (Strongest Basic)-2.1ChemAxon
Physiological Charge-1ChemAxon
Hydrogen Acceptor Count3ChemAxon
Hydrogen Donor Count2ChemAxon
Polar Surface Area49.33 Å2ChemAxon
Rotatable Bond Count4ChemAxon
Refractivity75.46 m3·mol-1ChemAxon
Polarizability27.93 Å3ChemAxon
Number of Rings2ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleYesChemAxon
Spectra
Mass Spec (NIST)Not Available
Spectra
Spectrum TypeDescriptionSplash Key
MSMass Spectrum (Electron Ionization)splash10-47z0000000-8fb3ce6f68fc69b5218eView in MoNA
References
Synthesis Reference

Takuzo Kamishita, “Gel preparations for topical application of diclofenac sodium.” U.S. Patent US4670254, issued October, 1983.

US4670254
General References
  1. Kearney PM, Baigent C, Godwin J, Halls H, Emberson JR, Patrono C: Do selective cyclo-oxygenase-2 inhibitors and traditional non-steroidal anti-inflammatory drugs increase the risk of atherothrombosis? Meta-analysis of randomised trials. BMJ. 2006 Jun 3;332(7553):1302-8. Pubmed
  2. Solomon DH, Avorn J, Sturmer T, Glynn RJ, Mogun H, Schneeweiss S: Cardiovascular outcomes in new users of coxibs and nonsteroidal antiinflammatory drugs: high-risk subgroups and time course of risk. Arthritis Rheum. 2006 May;54(5):1378-89. Pubmed
  3. FitzGerald GA, Patrono C: The coxibs, selective inhibitors of cyclooxygenase-2. N Engl J Med. 2001 Aug 9;345(6):433-42. Pubmed
  4. Graham DJ: COX-2 inhibitors, other NSAIDs, and cardiovascular risk: the seduction of common sense. JAMA. 2006 Oct 4;296(13):1653-6. Epub 2006 Sep 12. Pubmed
  5. Brater DC: Renal effects of cyclooxygyenase-2-selective inhibitors. J Pain Symptom Manage. 2002 Apr;23(4 Suppl):S15-20; discussion S21-3. Pubmed
  6. Sigma Aldrich Link
  7. Gan TJ: Diclofenac: an update on its mechanism of action and safety profile. Curr Med Res Opin. 2010 Jul;26(7):1715-31. Pubmed
External Links
ATC CodesD11AX18M01AB05M02AA15S01BC03
AHFS Codes
  • 28:08.04.08
  • 28:08.04.92
PDB EntriesNot Available
FDA labelDownload (37.5 KB)
MSDSDownload (73.6 KB)
Interactions
Drug Interactions
Drug
AbciximabDiclofenac may increase the anticoagulant activities of Abciximab.
AcenocoumarolDiclofenac may increase the anticoagulant activities of Acenocoumarol.
Acetylsalicylic acidThe risk or severity of adverse effects can be increased when Diclofenac is combined with Acetylsalicylic acid.
AliskirenDiclofenac may decrease the antihypertensive activities of Aliskiren.
AlteplaseDiclofenac may increase the anticoagulant activities of Alteplase.
AmikacinDiclofenac may decrease the excretion rate of Amikacin which could result in a lower serum level and potentially a reduction in efficacy.
AmitriptylineAmitriptyline may increase the antiplatelet activities of Diclofenac.
AnistreplaseDiclofenac may increase the anticoagulant activities of Anistreplase.
ApixabanThe risk or severity of adverse effects can be increased when Diclofenac is combined with Apixaban.
AprepitantThe serum concentration of Diclofenac can be decreased when it is combined with Aprepitant.
ArbekacinDiclofenac may decrease the excretion rate of Arbekacin which could result in a lower serum level and potentially a reduction in efficacy.
BalsalazideDiclofenac may increase the nephrotoxic activities of Balsalazide.
CapecitabineThe serum concentration of Diclofenac can be increased when it is combined with Capecitabine.
CarbamazepineThe serum concentration of Diclofenac can be decreased when it is combined with Carbamazepine.
Citric AcidDiclofenac may increase the anticoagulant activities of Citric Acid.
ColesevelamColesevelam can cause a decrease in the absorption of Diclofenac resulting in a reduced serum concentration and potentially a decrease in efficacy.
CollagenaseThe risk or severity of adverse effects can be increased when Diclofenac is combined with Collagenase.
CyclosporineDiclofenac may increase the nephrotoxic activities of Cyclosporine.
Dabigatran etexilateDiclofenac may increase the anticoagulant activities of Dabigatran etexilate.
DalteparinDiclofenac may increase the anticoagulant activities of Dalteparin.
DasatinibDasatinib may increase the anticoagulant activities of Diclofenac.
DeferasiroxThe risk or severity of adverse effects can be increased when Diclofenac is combined with Deferasirox.
DeferiproneThe serum concentration of Deferiprone can be increased when it is combined with Diclofenac.
DelavirdineThe serum concentration of Diclofenac can be increased when it is combined with Delavirdine.
Deoxycholic AcidThe risk or severity of adverse effects can be increased when Diclofenac is combined with Deoxycholic Acid.
DesmopressinThe risk or severity of adverse effects can be increased when Diclofenac is combined with Desmopressin.
DexketoprofenThe risk or severity of adverse effects can be increased when Dexketoprofen is combined with Diclofenac.
DicoumarolDiclofenac may increase the anticoagulant activities of Dicoumarol.
DiflunisalThe risk or severity of adverse effects can be increased when Diclofenac is combined with Diflunisal.
DigoxinThe serum concentration of Digoxin can be increased when it is combined with Diclofenac.
DrospirenoneDiclofenac may increase the hyperkalemic activities of Drospirenone.
Edetic AcidDiclofenac may increase the anticoagulant activities of Edetic Acid.
EnoxaparinDiclofenac may increase the anticoagulant activities of Enoxaparin.
EplerenoneDiclofenac may decrease the antihypertensive activities of Eplerenone.
ErythromycinThe serum concentration of Diclofenac can be increased when it is combined with Erythromycin.
Ethyl biscoumacetateDiclofenac may increase the anticoagulant activities of Ethyl biscoumacetate.
EtodolacThe risk or severity of adverse effects can be increased when Diclofenac is combined with Etodolac.
FenoprofenThe risk or severity of adverse effects can be increased when Diclofenac is combined with Fenoprofen.
FloctafenineThe risk or severity of adverse effects can be increased when Floctafenine is combined with Diclofenac.
FloxuridineThe serum concentration of Diclofenac can be increased when it is combined with Floxuridine.
FludrocortisoneThe risk or severity of adverse effects can be increased when Fludrocortisone is combined with Diclofenac.
FluorouracilThe serum concentration of Diclofenac can be increased when it is combined with Fluorouracil.
FlurbiprofenThe risk or severity of adverse effects can be increased when Diclofenac is combined with Flurbiprofen.
Fondaparinux sodiumDiclofenac may increase the anticoagulant activities of Fondaparinux sodium.
FosphenytoinThe serum concentration of Diclofenac can be decreased when it is combined with Fosphenytoin.
FramycetinDiclofenac may decrease the excretion rate of Framycetin which could result in a lower serum level and potentially a reduction in efficacy.
GemfibrozilThe serum concentration of Diclofenac can be increased when it is combined with Gemfibrozil.
GentamicinDiclofenac may decrease the excretion rate of Gentamicin which could result in a lower serum level and potentially a reduction in efficacy.
GlucosamineGlucosamine may increase the antiplatelet activities of Diclofenac.
HaloperidolThe risk or severity of adverse effects can be increased when Diclofenac is combined with Haloperidol.
HeparinDiclofenac may increase the anticoagulant activities of Heparin.
HomoharringtonineThe risk or severity of adverse effects can be increased when Diclofenac is combined with Homoharringtonine.
HydralazineDiclofenac may decrease the antihypertensive activities of Hydralazine.
IbritumomabThe risk or severity of adverse effects can be increased when Diclofenac is combined with Ibritumomab.
IbrutinibThe risk or severity of adverse effects can be increased when Ibrutinib is combined with Diclofenac.
IbuprofenThe risk or severity of adverse effects can be increased when Diclofenac is combined with Ibuprofen.
IcosapentThe risk or severity of adverse effects can be increased when Diclofenac is combined with Icosapent.
IndomethacinThe risk or severity of adverse effects can be increased when Diclofenac is combined with Indomethacin.
InfliximabThe risk or severity of adverse effects can be increased when Diclofenac is combined with Infliximab.
KanamycinDiclofenac may decrease the excretion rate of Kanamycin which could result in a lower serum level and potentially a reduction in efficacy.
KetoprofenThe risk or severity of adverse effects can be increased when Diclofenac is combined with Ketoprofen.
KetorolacThe risk or severity of adverse effects can be increased when Ketorolac is combined with Diclofenac.
LimaprostLimaprost may increase the antiplatelet activities of Diclofenac.
LithiumThe serum concentration of Lithium can be increased when it is combined with Diclofenac.
Mefenamic acidThe risk or severity of adverse effects can be increased when Diclofenac is combined with Mefenamic acid.
MeloxicamThe risk or severity of adverse effects can be increased when Diclofenac is combined with Meloxicam.
MethotrexateThe serum concentration of Methotrexate can be increased when it is combined with Diclofenac.
MorniflumateThe risk or severity of adverse effects can be increased when Morniflumate is combined with Diclofenac.
NabumetoneThe risk or severity of adverse effects can be increased when Diclofenac is combined with Nabumetone.
NadololDiclofenac may decrease the antihypertensive activities of Nadolol.
NaproxenThe risk or severity of adverse effects can be increased when Diclofenac is combined with Naproxen.
NeomycinDiclofenac may decrease the excretion rate of Neomycin which could result in a lower serum level and potentially a reduction in efficacy.
NetilmicinDiclofenac may decrease the excretion rate of Netilmicin which could result in a lower serum level and potentially a reduction in efficacy.
NicardipineThe serum concentration of Diclofenac can be increased when it is combined with Nicardipine.
ObinutuzumabThe risk or severity of adverse effects can be increased when Diclofenac is combined with Obinutuzumab.
Omega-3 fatty acidsOmega-3 fatty acids may increase the antiplatelet activities of Diclofenac.
OxaprozinThe risk or severity of adverse effects can be increased when Diclofenac is combined with Oxaprozin.
PamidronateThe risk or severity of adverse effects can be increased when Diclofenac is combined with Pamidronate.
ParoxetineParoxetine may increase the antiplatelet activities of Diclofenac.
PemetrexedThe serum concentration of Pemetrexed can be increased when it is combined with Diclofenac.
Pentosan PolysulfateThe risk or severity of adverse effects can be increased when Pentosan Polysulfate is combined with Diclofenac.
PentoxifyllinePentoxifylline may increase the antiplatelet activities of Diclofenac.
PerindoprilThe risk or severity of adverse effects can be increased when Perindopril is combined with Diclofenac.
PhenindioneDiclofenac may increase the anticoagulant activities of Phenindione.
PhenobarbitalThe serum concentration of Diclofenac can be decreased when it is combined with Phenobarbital.
PhenprocoumonDiclofenac may increase the anticoagulant activities of Phenprocoumon.
PhenytoinThe serum concentration of Diclofenac can be decreased when it is combined with Phenytoin.
PiroxicamThe risk or severity of adverse effects can be increased when Diclofenac is combined with Piroxicam.
PorfimerDiclofenac may increase the photosensitizing activities of Porfimer.
PralatrexateThe serum concentration of Pralatrexate can be increased when it is combined with Diclofenac.
PrimidoneThe serum concentration of Diclofenac can be decreased when it is combined with Primidone.
ProbenecidThe serum concentration of Diclofenac can be increased when it is combined with Probenecid.
ReteplaseDiclofenac may increase the anticoagulant activities of Reteplase.
RibostamycinDiclofenac may decrease the excretion rate of Ribostamycin which could result in a lower serum level and potentially a reduction in efficacy.
RidogrelDiclofenac may increase the anticoagulant activities of Ridogrel.
RifampicinThe serum concentration of Diclofenac can be decreased when it is combined with Rifampicin.
RifapentineThe serum concentration of Diclofenac can be decreased when it is combined with Rifapentine.
RivaroxabanDiclofenac may increase the anticoagulant activities of Rivaroxaban.
Salicylate-sodiumThe risk or severity of adverse effects can be increased when Diclofenac is combined with Salicylate-sodium.
SecobarbitalThe serum concentration of Diclofenac can be decreased when it is combined with Secobarbital.
SparfloxacinDiclofenac may increase the neuroexcitatory activities of Sparfloxacin.
SpectinomycinDiclofenac may decrease the excretion rate of Spectinomycin which could result in a lower serum level and potentially a reduction in efficacy.
StreptokinaseDiclofenac may increase the anticoagulant activities of Streptokinase.
StreptomycinDiclofenac may decrease the excretion rate of Streptomycin which could result in a lower serum level and potentially a reduction in efficacy.
SulfadiazineThe serum concentration of Diclofenac can be increased when it is combined with Sulfadiazine.
SulfisoxazoleThe serum concentration of Diclofenac can be increased when it is combined with Sulfisoxazole.
SulindacThe risk or severity of adverse effects can be increased when Diclofenac is combined with Sulindac.
SulodexideDiclofenac may increase the anticoagulant activities of Sulodexide.
TacrolimusDiclofenac may increase the nephrotoxic activities of Tacrolimus.
TalniflumateThe risk or severity of adverse effects can be increased when Talniflumate is combined with Diclofenac.
TenecteplaseDiclofenac may increase the anticoagulant activities of Tenecteplase.
TenofovirThe risk or severity of adverse effects can be increased when Diclofenac is combined with Tenofovir.
Tiaprofenic acidThe risk or severity of adverse effects can be increased when Diclofenac is combined with Tiaprofenic acid.
TipranavirTipranavir may increase the antiplatelet activities of Diclofenac.
TizanidineThe serum concentration of Tizanidine can be increased when it is combined with Diclofenac.
TobramycinDiclofenac may decrease the excretion rate of Tobramycin which could result in a lower serum level and potentially a reduction in efficacy.
TolbutamideThe serum concentration of Diclofenac can be increased when it is combined with Tolbutamide.
TolmetinThe risk or severity of adverse effects can be increased when Diclofenac is combined with Tolmetin.
TorasemideDiclofenac may decrease the diuretic activities of Torasemide.
TositumomabThe risk or severity of adverse effects can be increased when Diclofenac is combined with Tositumomab.
TreprostinilThe risk or severity of adverse effects can be increased when Treprostinil is combined with Diclofenac.
TriamtereneDiclofenac may decrease the antihypertensive activities of Triamterene.
TrichlormethiazideThe therapeutic efficacy of Trichlormethiazide can be decreased when used in combination with Diclofenac.
UnoprostoneThe therapeutic efficacy of Unoprostone can be decreased when used in combination with Diclofenac.
UrokinaseDiclofenac may increase the anticoagulant activities of Urokinase.
ValsartanThe risk or severity of adverse effects can be increased when Valsartan is combined with Diclofenac.
VancomycinThe serum concentration of Vancomycin can be increased when it is combined with Diclofenac.
VenlafaxineVenlafaxine may increase the antiplatelet activities of Diclofenac.
VerteporfinDiclofenac may increase the photosensitizing activities of Verteporfin.
Vitamin EVitamin E may increase the antiplatelet activities of Diclofenac.
VoriconazoleThe serum concentration of Diclofenac can be increased when it is combined with Voriconazole.
WarfarinDiclofenac may increase the anticoagulant activities of Warfarin.
Food Interactions
  • Avoid alcohol.
  • Take with food to reduce irritation.

Targets

1. Prostaglandin G/H synthase 2

Kind: Protein

Organism: Human

Pharmacological action: yes

Actions: inhibitor

Components

Name UniProt ID Details
Prostaglandin G/H synthase 2 P35354 Details

References:

  1. Kirchheiner J, Meineke I, Steinbach N, Meisel C, Roots I, Brockmoller J: Pharmacokinetics of diclofenac and inhibition of cyclooxygenases 1 and 2: no relationship to the CYP2C9 genetic polymorphism in humans. Br J Clin Pharmacol. 2003 Jan;55(1):51-61. Pubmed
  2. Blomme EA, Chinn KS, Hardy MM, Casler JJ, Kim SH, Opsahl AC, Hall WA, Trajkovic D, Khan KN, Tripp CS: Selective cyclooxygenase-2 inhibition does not affect the healing of cutaneous full-thickness incisional wounds in SKH-1 mice. Br J Dermatol. 2003 Feb;148(2):211-23. Pubmed
  3. Beubler E: [Pharmacology of cyclooxygenase 2 inhibition] Wien Med Wochenschr. 2003;153(5-6):95-9. Pubmed
  4. Chavez ML, DeKorte CJ: Valdecoxib: a review. Clin Ther. 2003 Mar;25(3):817-51. Pubmed
  5. Rowlinson SW, Kiefer JR, Prusakiewicz JJ, Pawlitz JL, Kozak KR, Kalgutkar AS, Stallings WC, Kurumbail RG, Marnett LJ: A novel mechanism of cyclooxygenase-2 inhibition involving interactions with Ser-530 and Tyr-385. J Biol Chem. 2003 Nov 14;278(46):45763-9. Epub 2003 Aug 18. Pubmed

2. Prostaglandin G/H synthase 1

Kind: Protein

Organism: Human

Pharmacological action: yes

Actions: inhibitor

Components

Name UniProt ID Details
Prostaglandin G/H synthase 1 P23219 Details

References:

  1. Calkin AC, Sudhir K, Honisett S, Williams MR, Dawood T, Komesaroff PA: Rapid potentiation of endothelium-dependent vasodilation by estradiol in postmenopausal women is mediated via cyclooxygenase 2. J Clin Endocrinol Metab. 2002 Nov;87(11):5072-5. Pubmed
  2. Kirchheiner J, Meineke I, Steinbach N, Meisel C, Roots I, Brockmoller J: Pharmacokinetics of diclofenac and inhibition of cyclooxygenases 1 and 2: no relationship to the CYP2C9 genetic polymorphism in humans. Br J Clin Pharmacol. 2003 Jan;55(1):51-61. Pubmed
  3. Kampfer H, Brautigam L, Geisslinger G, Pfeilschifter J, Frank S: Cyclooxygenase-1-coupled prostaglandin biosynthesis constitutes an essential prerequisite for skin repair. J Invest Dermatol. 2003 May;120(5):880-90. Pubmed
  4. Chavez ML, DeKorte CJ: Valdecoxib: a review. Clin Ther. 2003 Mar;25(3):817-51. Pubmed
  5. Hinz B, Rau T, Auge D, Werner U, Ramer R, Rietbrock S, Brune K: Aceclofenac spares cyclooxygenase 1 as a result of limited but sustained biotransformation to diclofenac. Clin Pharmacol Ther. 2003 Sep;74(3):222-35. Pubmed
  6. Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. Pubmed

3. Arachidonate 5-lipoxygenase

Kind: Protein

Organism: Human

Pharmacological action: yes

Actions: potentiator

Components

Name UniProt ID Details
Arachidonate 5-lipoxygenase P09917 Details

References:

  1. Charlier C, Michaux C: Dual inhibition of cyclooxygenase-2 (COX-2) and 5-lipoxygenase (5-LOX) as a new strategy to provide safer non-steroidal anti-inflammatory drugs. Eur J Med Chem. 2003 Jul-Aug;38(7-8):645-59. Pubmed
  2. Kudo C, Kori M, Matsuzaki K, Yamai K, Nakajima A, Shibuya A, Niwa H, Kamisaki Y, Wada K: Diclofenac inhibits proliferation and differentiation of neural stem cells. Biochem Pharmacol. 2003 Jul 15;66(2):289-95. Pubmed
  3. Whittle BJ: Cyclooxygenase and nitric oxide systems in the gut as therapeutic targets for safer anti-inflammatory drugs. Curr Opin Pharmacol. 2004 Dec;4(6):538-45. Pubmed

4. Sodium channel protein type 4 subunit alpha

Kind: Protein

Organism: Human

Pharmacological action: yes

Actions: inhibitor

Components

Name UniProt ID Details
Sodium channel protein type 4 subunit alpha P35499 Details

References:

  1. Yang YC, Kuo CC: An inactivation stabilizer of the Na+ channel acts as an opportunistic pore blocker modulated by external Na+. J Gen Physiol. 2005 May;125(5):465-81. Epub 2005 Apr 11. Pubmed
  2. Voilley N: Acid-sensing ion channels (ASICs): new targets for the analgesic effects of non-steroid anti-inflammatory drugs (NSAIDs). Curr Drug Targets Inflamm Allergy. 2004 Mar;3(1):71-9. Pubmed
  3. Jones NG, Slater R, Cadiou H, McNaughton P, McMahon SB: Acid-induced pain and its modulation in humans. J Neurosci. 2004 Dec 1;24(48):10974-9. Pubmed

5. Acid-sensing ion channel 1

Kind: Protein

Organism: Human

Pharmacological action: yes

Actions: inhibitor

Components

Name UniProt ID Details
Acid-sensing ion channel 1 P78348 Details

References:

  1. Voilley N, de Weille J, Mamet J, Lazdunski M: Nonsteroid anti-inflammatory drugs inhibit both the activity and the inflammation-induced expression of acid-sensing ion channels in nociceptors. J Neurosci. 2001 Oct 15;21(20):8026-33. Pubmed

6. Potassium voltage-gated channel subfamily KQT member 2

Kind: Protein

Organism: Human

Pharmacological action: yes

Actions: other

Components

Name UniProt ID Details
Potassium voltage-gated channel subfamily KQT member 2 O43526 Details

References:

  1. Peretz A, Degani N, Nachman R, Uziyel Y, Gibor G, Shabat D, Attali B: Meclofenamic acid and diclofenac, novel templates of KCNQ2/Q3 potassium channel openers, depress cortical neuron activity and exhibit anticonvulsant properties. Mol Pharmacol. 2005 Apr;67(4):1053-66. Epub 2004 Dec 14. Pubmed
  2. Xiong Q, Gao Z, Wang W, Li M: Activation of Kv7 (KCNQ) voltage-gated potassium channels by synthetic compounds. Trends Pharmacol Sci. 2008 Feb;29(2):99-107. Epub 2008 Jan 18. Pubmed

7. Potassium voltage-gated channel subfamily KQT member 3

Kind: Protein

Organism: Human

Pharmacological action: yes

Actions: other

Components

Name UniProt ID Details
Potassium voltage-gated channel subfamily KQT member 3 O43525 Details

References:

  1. Xiong Q, Gao Z, Wang W, Li M: Activation of Kv7 (KCNQ) voltage-gated potassium channels by synthetic compounds. Trends Pharmacol Sci. 2008 Feb;29(2):99-107. Epub 2008 Jan 18. Pubmed
  2. Peretz A, Degani N, Nachman R, Uziyel Y, Gibor G, Shabat D, Attali B: Meclofenamic acid and diclofenac, novel templates of KCNQ2/Q3 potassium channel openers, depress cortical neuron activity and exhibit anticonvulsant properties. Mol Pharmacol. 2005 Apr;67(4):1053-66. Epub 2004 Dec 14. Pubmed

8. Phospholipase A2, membrane associated

Kind: Protein

Organism: Human

Pharmacological action: unknown

Actions: inhibitor

Components

Name UniProt ID Details
Phospholipase A2, membrane associated P14555 Details

References:

  1. Madanick RD, O’Loughlin CJ, Barkin JS: Diclofenac reduces the incidence of acute pancreatitis after endoscopic retrograde cholangiopancreatography. Dig Dis Sci. 2005 May;50(5):879-81. Pubmed
  2. Singh N, Jabeen T, Sharma S, Somvanshi RK, Dey S, Srinivasan A, Singh TP: Specific binding of non-steroidal anti-inflammatory drugs (NSAIDs) to phospholipase A2: structure of the complex formed between phospholipase A2 and diclofenac at 2.7 A resolution. Acta Crystallogr D Biol Crystallogr. 2006 Apr;62(Pt 4):410-6. Epub 2006 Mar 18. Pubmed
  3. Makela A, Kuusi T, Schroder T: Inhibition of serum phospholipase-A2 in acute pancreatitis by pharmacological agents in vitro. Scand J Clin Lab Invest. 1997 Aug;57(5):401-7. Pubmed

Enzymes

1. Cytochrome P450 2C9

Kind: Protein

Organism: Human

Pharmacological action: unknown

Actions: substrate inhibitor

Components

Name UniProt ID Details
Cytochrome P450 2C9 P11712 Details

References:

  1. Mo SL, Zhou ZW, Yang LP, Wei MQ, Zhou SF: New insights into the structural features and functional relevance of human cytochrome P450 2C9. Part I. Curr Drug Metab. 2009 Dec;10(10):1075-126. Pubmed
  2. Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. Pubmed
  3. Flockhart DA. Drug Interactions: Cytochrome P450 Drug Interaction Table. Indiana University School of Medicine (2007). Accessed May 28, 2010.
  4. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. Pubmed
  5. Obach RS, Reed-Hagen AE: Measurement of Michaelis constants for cytochrome P450-mediated biotransformation reactions using a substrate depletion approach. Drug Metab Dispos. 2002 Jul;30(7):831-7. Pubmed
  6. Leemann T, Transon C, Dayer P: Cytochrome P450TB (CYP2C): a major monooxygenase catalyzing diclofenac 4’-hydroxylation in human liver. Life Sci. 1993;52(1):29-34. Pubmed

2. Cytochrome P450 2C19

Kind: Protein

Organism: Human

Pharmacological action: unknown

Actions: substrate

Components

Name UniProt ID Details
Cytochrome P450 2C19 P33261 Details

References:

  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. Pubmed

3. Cytochrome P450 1A2

Kind: Protein

Organism: Human

Pharmacological action: unknown

Actions: substrate inhibitor

Components

Name UniProt ID Details
Cytochrome P450 1A2 P05177 Details

References:

  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. Pubmed

4. Cytochrome P450 2C8

Kind: Protein

Organism: Human

Pharmacological action: unknown

Actions: substrate

Components

Name UniProt ID Details
Cytochrome P450 2C8 P10632 Details

References:

  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. Pubmed

5. UDP-glucuronosyltransferase 1-1

Kind: Protein

Organism: Human

Pharmacological action: unknown

Actions: substrate

Components

Name UniProt ID Details
UDP-glucuronosyltransferase 1-1 P22309 Details

References:

  1. Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. Pubmed

6. UDP-glucuronosyltransferase 2B7

Kind: Protein

Organism: Human

Pharmacological action: unknown

Actions: substrate

Components

Name UniProt ID Details
UDP-glucuronosyltransferase 2B7 P16662 Details

References:

  1. Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. Pubmed

7. Prostaglandin G/H synthase 1

Kind: Protein

Organism: Human

Pharmacological action: unknown

Actions: substrate

Components

Name UniProt ID Details
Prostaglandin G/H synthase 1 P23219 Details

References:

  1. Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. Pubmed

8. Cytochrome P450 3A4

Kind: Protein

Organism: Human

Pharmacological action: unknown

Actions: substrate

Components

Name UniProt ID Details
Cytochrome P450 3A4 P08684 Details

References:

  1. Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. Pubmed
  2. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. Pubmed

9. Cytochrome P450 1A1

Kind: Protein

Organism: Human

Pharmacological action: unknown

Actions: substrate

Components

Name UniProt ID Details
Cytochrome P450 1A1 P04798 Details

References:

  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. Pubmed

10. Cytochrome P450 2B6

Kind: Protein

Organism: Human

Pharmacological action: unknown

Actions: substrate

Components

Name UniProt ID Details
Cytochrome P450 2B6 P20813 Details

References:

  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. Pubmed

11. Cytochrome P450 2C18

Kind: Protein

Organism: Human

Pharmacological action: unknown

Actions: substrate

Components

Name UniProt ID Details
Cytochrome P450 2C18 P33260 Details

References:

  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. Pubmed

12. Cytochrome P450 2E1

Kind: Protein

Organism: Human

Pharmacological action: unknown

Actions: inhibitor

Components

Name UniProt ID Details
Cytochrome P450 2E1 P05181 Details

References:

  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. Pubmed

Carriers

1. Transthyretin

Kind: Protein

Organism: Human

Pharmacological action: unknown

Components

Name UniProt ID Details
Transthyretin P02766 Details

References:

  1. Miller SR, Sekijima Y, Kelly JW: Native state stabilization by NSAIDs inhibits transthyretin amyloidogenesis from the most common familial disease variants. Lab Invest. 2004 May;84(5):545-52. Pubmed
  2. Almeida MR, Macedo B, Cardoso I, Alves I, Valencia G, Arsequell G, Planas A, Saraiva MJ: Selective binding to transthyretin and tetramer stabilization in serum from patients with familial amyloidotic polyneuropathy by an iodinated diflunisal derivative. Biochem J. 2004 Jul 15;381(Pt 2):351-6. Pubmed

2. Serum albumin

Kind: Protein

Organism: Human

Pharmacological action: unknown

Components

Name UniProt ID Details
Serum albumin P02768 Details

References:

  1. Yamasaki K, Rahman MH, Tsutsumi Y, Maruyama T, Ahmed S, Kragh-Hansen U, Otagiri M: Circular dichroism simulation shows a site-II-to-site-I displacement of human serum albumin-bound diclofenac by ibuprofen. AAPS PharmSciTech. 2000 May 14;1(2):E12. Pubmed

Transporters

1. Multidrug resistance-associated protein 4

Kind: Protein

Organism: Human

Pharmacological action: unknown

Actions: inhibitor

Components

Name UniProt ID Details
Multidrug resistance-associated protein 4 O15439 Details

References:

  1. Reid G, Wielinga P, Zelcer N, van der Heijden I, Kuil A, de Haas M, Wijnholds J, Borst P: The human multidrug resistance protein MRP4 functions as a prostaglandin efflux transporter and is inhibited by nonsteroidal antiinflammatory drugs. Proc Natl Acad Sci U S A. 2003 Aug 5;100(16):9244-9. Epub 2003 Jun 30. Pubmed

2. Multidrug resistance protein 1

Kind: Protein

Organism: Human

Pharmacological action: unknown

Actions: inhibitor

Components

Name UniProt ID Details
Multidrug resistance protein 1 P08183 Details

References:

  1. Wang E, Lew K, Barecki M, Casciano CN, Clement RP, Johnson WW: Quantitative distinctions of active site molecular recognition by P-glycoprotein and cytochrome P450 3A4. Chem Res Toxicol. 2001 Dec;14(12):1596-603. Pubmed

3. Multidrug resistance-associated protein 1

Kind: Protein

Organism: Human

Pharmacological action: unknown

Actions: inhibitor

Components

Name UniProt ID Details
Multidrug resistance-associated protein 1 P33527 Details

References:

  1. Reid G, Wielinga P, Zelcer N, van der Heijden I, Kuil A, de Haas M, Wijnholds J, Borst P: The human multidrug resistance protein MRP4 functions as a prostaglandin efflux transporter and is inhibited by nonsteroidal antiinflammatory drugs. Proc Natl Acad Sci U S A. 2003 Aug 5;100(16):9244-9. Epub 2003 Jun 30. Pubmed

4. Solute carrier family 22 member 6

Kind: Protein

Organism: Human

Pharmacological action: unknown

Actions: inhibitor

Components

Name UniProt ID Details
Solute carrier family 22 member 6 Q4U2R8 Details

References:

  1. Mulato AS, Ho ES, Cihlar T: Nonsteroidal anti-inflammatory drugs efficiently reduce the transport and cytotoxicity of adefovir mediated by the human renal organic anion transporter 1. J Pharmacol Exp Ther. 2000 Oct;295(1):10-5. Pubmed
  2. Kuze K, Graves P, Leahy A, Wilson P, Stuhlmann H, You G: Heterologous expression and functional characterization of a mouse renal organic anion transporter in mammalian cells. J Biol Chem. 1999 Jan 15;274(3):1519-24. Pubmed
  3. Apiwattanakul N, Sekine T, Chairoungdua A, Kanai Y, Nakajima N, Sophasan S, Endou H: Transport properties of nonsteroidal anti-inflammatory drugs by organic anion transporter 1 expressed in Xenopus laevis oocytes. Mol Pharmacol. 1999 May;55(5):847-54. Pubmed

5. Solute carrier family 22 member 8

Kind: Protein

Organism: Human

Pharmacological action: unknown

Actions: inhibitor

Components

Name UniProt ID Details
Solute carrier family 22 member 8 Q8TCC7 Details

References:

  1. Cha SH, Sekine T, Fukushima JI, Kanai Y, Kobayashi Y, Goya T, Endou H: Identification and characterization of human organic anion transporter 3 expressing predominantly in the kidney. Mol Pharmacol. 2001 May;59(5):1277-86. Pubmed

6. Solute carrier organic anion transporter family member 1C1

Kind: Protein

Organism: Human

Pharmacological action: unknown

Actions: inhibitor

Components

Name UniProt ID Details
Solute carrier organic anion transporter family member 1C1 Q9NYB5 Details

References:

  1. Westholm DE, Stenehjem DD, Rumbley JN, Drewes LR, Anderson GW: Competitive inhibition of organic anion transporting polypeptide 1c1-mediated thyroxine transport by the fenamate class of nonsteroidal antiinflammatory drugs. Endocrinology. 2009 Feb;150(2):1025-32. Epub 2008 Oct 9. Pubmed
  2. Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. Pubmed

7. Solute carrier family 22 member 11

Kind: Protein

Organism: Human

Pharmacological action: unknown

Actions: inhibitor

Components

Name UniProt ID Details
Solute carrier family 22 member 11 Q9NSA0 Details

References:

  1. Cha SH, Sekine T, Kusuhara H, Yu E, Kim JY, Kim DK, Sugiyama Y, Kanai Y, Endou H: Molecular cloning and characterization of multispecific organic anion transporter 4 expressed in the placenta. J Biol Chem. 2000 Feb 11;275(6):4507-12. Pubmed

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Drug created on June 13, 2005 07:24 / Updated on November 27, 2015 16:54