G protein-activated inward rectifier potassium channel 1
Details
- Name
- G protein-activated inward rectifier potassium channel 1
- Synonyms
- GIRK-1
- GIRK1
- Inward rectifier K(+) channel Kir3.1
- Potassium channel, inwardly rectifying subfamily J member 3
- Gene Name
- KCNJ3
- Organism
- Humans
- Amino acid sequence
>lcl|BSEQ0002047|G protein-activated inward rectifier potassium channel 1 MSALRRKFGDDYQVVTTSSSGSGLQPQGPGQDPQQQLVPKKKRQRFVDKNGRCNVQHGNL GSETSRYLSDLFTTLVDLKWRWNLFIFILTYTVAWLFMASMWWVIAYTRGDLNKAHVGNY TPCVANVYNFPSAFLFFIETEATIGYGYRYITDKCPEGIILFLFQSILGSIVDAFLIGCM FIKMSQPKKRAETLMFSEHAVISMRDGKLTLMFRVGNLRNSHMVSAQIRCKLLKSRQTPE GEFLPLDQLELDVGFSTGADQLFLVSPLTICHVIDAKSPFYDLSQRSMQTEQFEIVVILE GIVETTGMTCQARTSYTEDEVLWGHRFFPVISLEEGFFKVDYSQFHATFEVPTPPYSVKE QEEMLLMSSPLIAPAITNSKERHNSVECLDGLDDITTKLPSKLQKITGREDFPKKLLRMS STTSEKAYSLGDLPMKLQRISSVPGNSEEKLVSKTTKMLSDPMSQSVADLPPKLQKMAGG AARMEGNLPAKLRKMNSDRFT
- Number of residues
- 501
- Molecular Weight
- 56602.84
- Theoretical pI
- 8.36
- GO Classification
- FunctionsG-protein activated inward rectifier potassium channel activityProcessespotassium ion import / potassium ion transport / regulation of ion transmembrane transport / response to electrical stimulus / synaptic transmissionComponentsexternal side of plasma membrane / integral component of plasma membrane / plasma membrane / T-tubule / voltage-gated potassium channel complex
- General Function
- G-protein activated inward rectifier potassium channel activity
- Specific Function
- This potassium channel is controlled by G proteins. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. This receptor plays a crucial role in regulating the heartbeat.
- Pfam Domain Function
- IRK (PF01007)
- Transmembrane Regions
- 81-105 158-179
- Cellular Location
- Membrane
- Gene sequence
>lcl|BSEQ0010718|G protein-activated inward rectifier potassium channel 1 (KCNJ3) ATGTCTGCACTCCGAAGGAAATTTGGGGACGATTATCAGGTAGTGACCACATCGTCCAGC GGCTCGGGCTTGCAGCCCCAGGGGCCAGGCCAGGACCCTCAGCAGCAGCTTGTGCCCAAG AAGAAGCGGCAGCGGTTCGTGGACAAGAACGGCCGGTGCAATGTACAGCACGGCAACCTG GGCAGCGAGACAAGCCGCTACCTCTCGGACCTCTTCACCACGCTGGTGGACCTCAAGTGG CGCTGGAACCTCTTCATCTTCATTCTCACCTACACCGTGGCCTGGCTTTTCATGGCGTCC ATGTGGTGGGTGATCGCCTACACTCGGGGCGACCTGAACAAAGCCCACGTCGGTAACTAC ACGCCTTGCGTGGCCAATGTCTATAACTTCCCTTCTGCCTTCCTCTTCTTCATCGAGACG GAGGCCACCATCGGCTATGGCTACCGATACATCACAGACAAGTGCCCCGAGGGCATCATC CTCTTCCTCTTCCAGTCCATCCTGGGCTCCATCGTGGACGCCTTCCTCATCGGCTGCATG TTCATCAAGATGTCCCAGCCCAAGAAGCGCGCCGAGACCCTCATGTTCAGCGAGCACGCG GTGATCTCCATGAGGGACGGAAAACTCACGCTTATGTTCCGGGTGGGCAACCTGCGCAAC AGCCACATGGTCTCCGCGCAGATTCGCTGCAAGCTGCTCAAAGGATGA
- Chromosome Location
- 2
- Locus
- 2q24.1
- External Identifiers
Resource Link UniProtKB ID P48549 UniProtKB Entry Name KCNJ3_HUMAN GenBank Protein ID 1055028 GenBank Gene ID U39196 GenAtlas ID KCNJ3 HGNC ID HGNC:6264 - General References
- Chan KW, Langan MN, Sui JL, Kozak JA, Pabon A, Ladias JA, Logothetis DE: A recombinant inwardly rectifying potassium channel coupled to GTP-binding proteins. J Gen Physiol. 1996 Mar;107(3):381-97. [Article]
- Schoots O, Yue KT, MacDonald JF, Hampson DR, Nobrega JN, Dixon LM, Van Tol HH: Cloning of a G protein-activated inwardly rectifying potassium channel from human cerebellum. Brain Res Mol Brain Res. 1996 Jul;39(1-2):23-30. [Article]
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- Pabon A, Chan KW, Sui JL, Wu X, Logothetis DE, Thornhill WB: Glycosylation of GIRK1 at Asn119 and ROMK1 at Asn117 has different consequences in potassium channel function. J Biol Chem. 2000 Sep 29;275(39):30677-82. [Article]
Drug Relations
- Drug Relations
DrugBank ID Name Drug group Pharmacological action? Actions Details DB01159 Halothane approved, vet_approved unknown inhibitor Details DB02451 B-nonylglucoside experimental unknown Details DB00898 Ethanol approved unknown Details DB00289 Atomoxetine approved unknown inhibitor Details DB04855 Dronedarone approved yes inhibitor Details DB08954 Ifenprodil investigational, withdrawn unknown antagonist Details