Displaying drugs 151 - 175 of 918 in total
Rhizopus stolonifer
Rhizopus stolonifer is a fungus which can provoke allergic reactions. Rhizopus stolonifer extract is used in allergenic testing.
Approved
Matched Products: … Molds, Rusts and Smuts, Rhizopus nigricans …
Sarocladium strictum
Sarocladium strictum allergenic extract is used in allergenic testing.
Approved
Matched Synonyms: … Molds, rusts and smuts, acremonium strictum ... Molds, rusts and smuts, cephalosporium acremonium …
Matched Products: … Molds, Rusts and Smuts, Cephalosporium acremonium …
Matched Products: … Molds, Rusts and Smuts, Cephalosporium acremonium …
Esomeprazole
Esomeprazole, sold under the brand name Nexium, is a proton pump inhibitor (PPI) medication used for the management of gastroesophageal reflux disease (GERD), for gastric protection to prevent recurrence of stomach ulcers or gastric damage from chronic use of NSAIDs, and for the treatment of pathological hypersecretory conditions including Zollinger-Ellison...
Approved
Investigational
Matched Description: … and bone fractures later in life. ... B12, and an increased risk of developing hypomagnesemia and hypocalcemia which may contribute to osteoporosis ... gastric protection to prevent recurrence of stomach ulcers or gastric damage from chronic use of NSAIDs, and …
Matched Mixtures name: … Naproxen and esomeprazole magnesium ... Naproxen and esomeprazole magnesium ... Naproxen and Esomeprazole Magnesium …
Matched Salts name: … Esomeprazole magnesium trihydrate ... Esomeprazole magnesium ... Esomeprazole magnesium dihydrate …
Matched Categories: … Medications that reduce magnesium levels ... Alimentary Tract and Metabolism ... Antiinflammatory and Antirheumatic Products ... Omeprazole and enantiomer ... naproxen and esomeprazole …
Matched Products: … Up and Up Esomeprazole Magnesium ... Berkley and Jensen Heartburn Treatment ... Foster and Thrive Acid Reducer …
Matched Mixtures name: … Naproxen and esomeprazole magnesium ... Naproxen and esomeprazole magnesium ... Naproxen and Esomeprazole Magnesium …
Matched Salts name: … Esomeprazole magnesium trihydrate ... Esomeprazole magnesium ... Esomeprazole magnesium dihydrate …
Matched Categories: … Medications that reduce magnesium levels ... Alimentary Tract and Metabolism ... Antiinflammatory and Antirheumatic Products ... Omeprazole and enantiomer ... naproxen and esomeprazole …
Matched Products: … Up and Up Esomeprazole Magnesium ... Berkley and Jensen Heartburn Treatment ... Foster and Thrive Acid Reducer …
Urofollitropin
Urofollitropin is a urinary-derived follicle-stimulating hormone (FSH) that is extracted and purified from human urine samples. It consists of two non-covalently linked, non-identical glycoproteins designated as the alpha- and beta- subunits. The alpha- and beta- subunits have 92 and 111 amino acids. The alpha subunit is glycosylated at Asn 51...
Approved
Vet approved
Matched Description: … The alpha- and beta- subunits have 92 and 111 amino acids. ... 7 and Asn 24. ... Urofollitropin is a urinary-derived follicle-stimulating hormone (FSH) that is extracted and purified …
Matched Categories: … Amino Acids, Peptides, and Proteins ... Genito Urinary System and Sex Hormones ... Gonadotropins and Antigonadotropins ... Hormones, Hormone Substitutes, and Hormone Antagonists ... Sex Hormones and Modulators of the Genital System …
Matched Products: … BRAVELLE POWDER AND SOLVENT FOR SOLUTION FOR INJECTION 75 IU ... Fostimon 75 IU powder and solvent for solution for injection ... Fostimon 150 IU powder and solvent for solution for injection …
Matched Categories: … Amino Acids, Peptides, and Proteins ... Genito Urinary System and Sex Hormones ... Gonadotropins and Antigonadotropins ... Hormones, Hormone Substitutes, and Hormone Antagonists ... Sex Hormones and Modulators of the Genital System …
Matched Products: … BRAVELLE POWDER AND SOLVENT FOR SOLUTION FOR INJECTION 75 IU ... Fostimon 75 IU powder and solvent for solution for injection ... Fostimon 150 IU powder and solvent for solution for injection …
Plantago lanceolata pollen
Plantago lanceolata pollen is the pollen of the Plantago lanceolata plant. Plantago lanceolata pollen is mainly used in allergenic testing.
Approved
Matched Products: … Pollens - Weeds and Garden Plants, Plantain, English Plantago lanceolata …
Salsola kali pollen
Salsola kali pollen is the pollen of the Salsola kali plant. Salsola kali pollen is mainly used in allergenic testing.
Approved
Matched Products: … Pollens - Weeds and Garden Plants, Russian Thistle Salsola kali …
Pseudoephedrine
Pseudoephedrine is structurally related to ephedrine but exerts a weaker effect on the sympathetic nervous system.[A188820,A188823] Both drugs naturally occur in in ephedra plant which have a history of use in traditional Eastern medicine and were first researched in the west in 1889. The decongestant effect of pseudoephedrine was described...
Approved
Matched Description: … drugs naturally occur in in ephedra plant which have a history of use in traditional Eastern medicine and …
Matched Mixtures name: … Codeine Phosphate and Pseudoephedrine Hydrochloride ... Up and Up Cold and Sinus ... Robitussin Cough and Cold D …
Matched Categories: … Alpha-and Beta-adrenergic Agonists …
Matched Products: … Up and Up Suphedrine ... UP AND UP nasal decongestant ... Up and Up 12 Hour Nasal Decongestant …
Matched Mixtures name: … Codeine Phosphate and Pseudoephedrine Hydrochloride ... Up and Up Cold and Sinus ... Robitussin Cough and Cold D …
Matched Categories: … Alpha-and Beta-adrenergic Agonists …
Matched Products: … Up and Up Suphedrine ... UP AND UP nasal decongestant ... Up and Up 12 Hour Nasal Decongestant …
Calcium chloride
Calcium chloride is an ionic compound of calcium and chlorine. It is highly soluble in water and it is deliquescent. It is a salt that is solid at room temperature, and it behaves as a typical ionic halide. It has several common applications such as brine for refrigeration plants, ice...
Approved
Matched Synonyms: … Calcio cloruro ... calcium(2+) chloride ... Calcium chloride anhydrous …
Matched Name: … Calcium chloride …
Matched Iupac: … calcium dichloride …
Matched Description: … Calcium chloride is an ionic compound of calcium and chlorine. ... , and in cement. ... It is highly soluble in water and it is deliquescent. …
Matched Mixtures name: … CALCIO E MAGNESIO CLORURO FKI ... CALCIO E MAGNESIO CLORURO MONICO ... Dianeal Pd4 Capd Solution With 1.5% Dextrose and 2.5meq/l Calcium …
Matched Salts name: … Calcium chloride dihydrate ... Calcium chloride hexahydrate …
Matched Categories: … ascorbic acid (vit C) and calcium ... Alimentary Tract and Metabolism ... Blood and Blood Forming Organs ... Blood Substitutes and Perfusion Solutions ... Genito Urinary System and Sex Hormones …
Matched Products: … Calcium Chloride ... CALCIO CLORURO ... CALCIO CLORURO MONICO …
Matched Name: … Calcium chloride …
Matched Iupac: … calcium dichloride …
Matched Description: … Calcium chloride is an ionic compound of calcium and chlorine. ... , and in cement. ... It is highly soluble in water and it is deliquescent. …
Matched Mixtures name: … CALCIO E MAGNESIO CLORURO FKI ... CALCIO E MAGNESIO CLORURO MONICO ... Dianeal Pd4 Capd Solution With 1.5% Dextrose and 2.5meq/l Calcium …
Matched Salts name: … Calcium chloride dihydrate ... Calcium chloride hexahydrate …
Matched Categories: … ascorbic acid (vit C) and calcium ... Alimentary Tract and Metabolism ... Blood and Blood Forming Organs ... Blood Substitutes and Perfusion Solutions ... Genito Urinary System and Sex Hormones …
Matched Products: … Calcium Chloride ... CALCIO CLORURO ... CALCIO CLORURO MONICO …
Arnica montana flower
Arnica montana flower is a plant/plant extract used in some OTC (over-the-counter) products. It is not an approved drug.
Approved
Experimental
Matched Synonyms: … Arnica Flower (Arnica Montana) ... Arnica Flower (Arnica Montana L.) ... Arnica Montana Oil …
Matched Name: … Arnica montana flower …
Matched Description: … Arnica montana flower is a plant/plant extract used in some OTC (over-the-counter) products. …
Matched Mixtures name: … Bee Venom Joint And Bone Therapy Drops ... DOCTOR HOYS Arnica Boost …
Matched Products: … Arnica Tct ... Naturland Arnica Cream …
Matched Name: … Arnica montana flower …
Matched Description: … Arnica montana flower is a plant/plant extract used in some OTC (over-the-counter) products. …
Matched Mixtures name: … Bee Venom Joint And Bone Therapy Drops ... DOCTOR HOYS Arnica Boost …
Matched Products: … Arnica Tct ... Naturland Arnica Cream …
DCVAC/OvCa
DCVAC/OvCa is a therapy comprising autologous dendritic cells pulsed with killed ovarian cancer cells and matured by TLR3 ligand ex vivo. It is under investigation for the treatment of ovarian cancer.
Investigational
Matched Synonyms: … Autologous dendritic cells pulsed with killed ovarian cancer cells and matured by TLR3 ligand ex vivo …
Matched Description: … DCVAC/OvCa is a therapy comprising autologous dendritic cells pulsed with killed ovarian cancer cells and …
Matched Description: … DCVAC/OvCa is a therapy comprising autologous dendritic cells pulsed with killed ovarian cancer cells and …
CHF5633
CHF5633 is a fully synthetic pulmonary surfactant preparation comprising DPPC (dipalmitoylphosphatidylcholine), POPG Na (palmitoyl‐oleoyl‐phosphatidylglycerol sodium), a synthetic SP-C analogue, and a synthetic SP-B analogue.
Investigational
Matched Synonyms: … Synthetic surfactant comprised of DPPC, POPG Na, synthetic SP-C analogue and synthetic SP-B analogue …
Matched Description: … dipalmitoylphosphatidylcholine), POPG Na (palmitoyl‐oleoyl‐phosphatidylglycerol sodium), a synthetic SP-C analogue, and …
Matched Categories: … Amino Acids, Peptides, and Proteins …
Matched Description: … dipalmitoylphosphatidylcholine), POPG Na (palmitoyl‐oleoyl‐phosphatidylglycerol sodium), a synthetic SP-C analogue, and …
Matched Categories: … Amino Acids, Peptides, and Proteins …
Goflikicept
Goflikicept is under investigation in clinical trial NCT04380519 (Study of the Efficacy and Safety of a Single Administration of Olokizumab and RPH-104 With Standard Therapy in Patients With Severe Severe Acute Respiratory Syndrome Coronavirus 2 (Sars-cov-2) Infection (COVID-19)).
Investigational
Matched Synonyms: … a mutant Fc fragment of human IGg1 and part of human IL1 receptor accessory protein ... Heterodimeric fusion protein that binds to IL-1 beta consisting of human extracellular domain of IL1 receptor and …
Matched Description: … Goflikicept is under investigation in clinical trial NCT04380519 (Study of the Efficacy and Safety of ... a Single Administration of Olokizumab and RPH-104 With Standard Therapy in Patients With Severe Severe …
Matched Description: … Goflikicept is under investigation in clinical trial NCT04380519 (Study of the Efficacy and Safety of ... a Single Administration of Olokizumab and RPH-104 With Standard Therapy in Patients With Severe Severe …
Dipotassium phosphate
Dipotassium phosphate (K2HPO4) is a highly water-soluble salt often used as a fertilizer and food additive as a source of phosphorus and potassium as well as a buffering agent.
Approved
Matched Synonyms: … Dibasic potassium phosphate ... Potassium phosphate dibasic ... Potassium phosphate,dibasic …
Matched Name: … Dipotassium phosphate …
Matched Iupac: … dipotassium hydrogen phosphate …
Matched Description: … Dipotassium phosphate (K2HPO4) is a highly water-soluble salt often used as a fertilizer and food additive ... as a source of phosphorus and potassium as well as a buffering agent. …
Matched Mixtures name: … Ionosol B and Dextrose ... Potassium Phosphates ... Potassium Phosphates …
Matched Categories: … Phosphate salts ... Phosphoric Acids …
Matched Name: … Dipotassium phosphate …
Matched Iupac: … dipotassium hydrogen phosphate …
Matched Description: … Dipotassium phosphate (K2HPO4) is a highly water-soluble salt often used as a fertilizer and food additive ... as a source of phosphorus and potassium as well as a buffering agent. …
Matched Mixtures name: … Ionosol B and Dextrose ... Potassium Phosphates ... Potassium Phosphates …
Matched Categories: … Phosphate salts ... Phosphoric Acids …
Ambrosia psilostachya pollen
Ambrosia psilostachya pollen is the pollen of the Ambrosia psilostachya plant. Ambrosia psilostachya pollen is mainly used in allergenic testing.
Approved
Matched Products: … Pollens - Weeds and Garden Plants, Ragweed. Western Ambrosia psilostachya …
Calcium gluconate
Calcium gluconate is used as mineral supplement and medication when there is insufficient calcium in the diet. Supplementation may be done to treat or prevent osteoporosis or rickets, consequences of hypocalcemia. It can also be taken by mouth but is not recommended by injection into a muscle.
Calcium Gluconate Injection,...
Approved
Vet approved
Matched Synonyms: … Calcii gluconas ... Calcio gluconato ... Calcium gluconate …
Matched Name: … Calcium gluconate …
Matched Iupac: … calcium bis((2R,3S,4R,5R)-2,3,4,5,6-pentahydroxyhexanoate) …
Matched Description: … Calcium gluconate is used as mineral supplement and medication when there is insufficient calcium in ... Calcium saccharate provides 6% of the total calcium and stabilizes the supersaturated solution of calcium ... Hydrochloric acid and/or sodium hydroxide may have been added for pH adjustment (6.0 to 8.2). …
Matched Mixtures name: … Calcium Magnesium Plus Vitamin D Liquid ... Calcium Liquid ... Calcium Liquid …
Matched Salts name: … Calcium gluconate monohydrate …
Matched Categories: … Alimentary Tract and Metabolism ... Calcium Salts ... calcium gluconate ... calcium gluconate …
Matched Products: … Calcium Gluconate ... CALCIUM GLUCONATE ... CALCIO GLUCONATO …
Matched Name: … Calcium gluconate …
Matched Iupac: … calcium bis((2R,3S,4R,5R)-2,3,4,5,6-pentahydroxyhexanoate) …
Matched Description: … Calcium gluconate is used as mineral supplement and medication when there is insufficient calcium in ... Calcium saccharate provides 6% of the total calcium and stabilizes the supersaturated solution of calcium ... Hydrochloric acid and/or sodium hydroxide may have been added for pH adjustment (6.0 to 8.2). …
Matched Mixtures name: … Calcium Magnesium Plus Vitamin D Liquid ... Calcium Liquid ... Calcium Liquid …
Matched Salts name: … Calcium gluconate monohydrate …
Matched Categories: … Alimentary Tract and Metabolism ... Calcium Salts ... calcium gluconate ... calcium gluconate …
Matched Products: … Calcium Gluconate ... CALCIUM GLUCONATE ... CALCIO GLUCONATO …
Penicillium chrysogenum var. chrysogenum
Penicillium chrysogenum var. chrysogenum is a fungus which can provoke allergic reactions. Penicillium chrysogenum var. chrysogenum extract is used in allergenic testing.
Approved
Matched Products: … Molds, Rusts and Smuts, Penicillium notatum …
Ambrosia trifida pollen
Ambrosia trifida pollen is the pollen of the Ambrosia trifida plant. Ambrosia trifida pollen is mainly used in allergenic testing.
Approved
Matched Mixtures name: … Short and Giant Ragweed Pollen Mix ... Pollens - Weeds and Garden Plants, Ragweed, Mixed Ambrosia ... Pollens - Weeds and Garden Plants, Ragweed, Mixed Ambrosia …
Matched Products: … Pollens - Weeds and Garden Plants, Ragweed, Giant Ambrosia trifida …
Matched Products: … Pollens - Weeds and Garden Plants, Ragweed, Giant Ambrosia trifida …
Artemisia vulgaris pollen
Artemisia vulgaris pollen is the pollen of the Artemisia vulgaris plant. Artemisia vulgaris pollen is mainly used in allergenic testing.
Approved
Matched Products: … Pollens - Weeds and Garden Plants, Sagebrush, Mugwort Artemisia vulgaris …
Tolfenamic acid
Tolfenamic acid, with the formula N-(2-methyl-3-chlorphenyl)-anthranilic acid, is a nonsteroidal anti-inflammatory agent. It was discovered by scientists at Medica Pharmaceutical Company in Finland. It is used in the UK as a treatment for migraine under the name of Clotam. In the US, it presents a Status class I by the...
Approved
Investigational
Matched Categories: … Calcium-Regulating Hormones and Agents ... Antiinflammatory and Antirheumatic Products ... Antiinflammatory and Antirheumatic Products, Non-Steroids ... Hormones, Hormone Substitutes, and Hormone Antagonists …
Matched Products: … TOLFEDINE 4% W/V SOLUTION FOR INJECTION FOR DOGS AND CATS …
Matched Products: … TOLFEDINE 4% W/V SOLUTION FOR INJECTION FOR DOGS AND CATS …
Aluminum sesquichlorohydrate
Aluminum sesquichlorohydrate is an aluminum salt used as an antiperspirant agent, cosmetic astringent and deodorant agent. It works by physically blocking eccrine sweat gland ducts .
Approved
Matched Description: … Aluminum sesquichlorohydrate is an aluminum salt used as an antiperspirant agent, cosmetic astringent and …
Matched Mixtures name: … Lactovit DEODORANT AND ANTIPERSPIRANT INVISIBLE ANTISTAIN …
Matched Products: … Fraicheur Verveine Antiperspirant and Deodorant Roll-ON ... Fraicheur The Vert Antiperspirant and Deodorant Roll-ON ... Cyzone Blue and Blue for Him …
Matched Mixtures name: … Lactovit DEODORANT AND ANTIPERSPIRANT INVISIBLE ANTISTAIN …
Matched Products: … Fraicheur Verveine Antiperspirant and Deodorant Roll-ON ... Fraicheur The Vert Antiperspirant and Deodorant Roll-ON ... Cyzone Blue and Blue for Him …
Calcium
Calcium plays a vital role in the anatomy, physiology and biochemistry of organisms and of the cell, particularly in signal transduction pathways. The skeleton acts as a major mineral storage site for the element and releases Ca2+ ions into the bloodstream under controlled conditions. Circulating calcium is either in the...
Nutraceutical
Matched Synonyms: … Calcio ... Calcium, elemental ... Elemental calcium …
Matched Name: … Calcium …
Matched Iupac: … calcium …
Matched Description: … The best-absorbed form of calcium from a pill is a calcium salt like carbonate or phosphate. ... Calcium plays a vital role in the anatomy, physiology and biochemistry of organisms and of the cell, ... Calcium gluconate and calcium lactate are absorbed well by pregnant women. …
Matched Mixtures name: … Oyster Shell Calcium with Vitamin D ... Oyster Shell Calcium with Vitamin D ... Active Calcium Plus Magnesium, Vitamin D and Silicon …
Matched Categories: … Phosphate Binder ... Phosphate Chelating Activity ... multivitamins and calcium ... Calcium-Regulating Hormones and Agents ... ascorbic acid (vit C) and calcium …
Matched Products: … Great Calcium ... Calcium ... 7030 Calcium Gold …
Matched Name: … Calcium …
Matched Iupac: … calcium …
Matched Description: … The best-absorbed form of calcium from a pill is a calcium salt like carbonate or phosphate. ... Calcium plays a vital role in the anatomy, physiology and biochemistry of organisms and of the cell, ... Calcium gluconate and calcium lactate are absorbed well by pregnant women. …
Matched Mixtures name: … Oyster Shell Calcium with Vitamin D ... Oyster Shell Calcium with Vitamin D ... Active Calcium Plus Magnesium, Vitamin D and Silicon …
Matched Categories: … Phosphate Binder ... Phosphate Chelating Activity ... multivitamins and calcium ... Calcium-Regulating Hormones and Agents ... ascorbic acid (vit C) and calcium …
Matched Products: … Great Calcium ... Calcium ... 7030 Calcium Gold …
Cetylpyridinium
Cetylpyridinium is a quaternary ammonium with broad-spectrum antiseptic properties. Its salt form, cetylpyridinium chloride, is typically found as an active ingredient in mouthwashes, toothpastes, lozenges, throat sprays, breath sprays, and nasal sprays. In these products, it generally mediates an antiseptic activity and protective action against dental plaque and reducing gingivitis.
Approved
Matched Description: … plaque and reducing gingivitis. ... found as an active ingredient in mouthwashes, toothpastes, lozenges, throat sprays, breath sprays, and ... In these products, it generally mediates an antiseptic activity and protective action against dental …
Matched Mixtures name: … QCare Oral Cleansing and Suctioning System, Q4 ... QCare Rx Oral Cleansing and Suctioning System ... QCare Rx Oral Cleansing and Suctioning System …
Matched Categories: … Antiseptics and Disinfectants ... Blood and Blood Forming Organs ... Blood Substitutes and Perfusion Solutions ... Mouthwashes and Gargles …
Matched Products: … SmartMouth Gum and Plaque Formula ... Qcare Oral Cleansing and Suctioning System ... Crest Pro-Health Gum and Breath Purify …
Matched Mixtures name: … QCare Oral Cleansing and Suctioning System, Q4 ... QCare Rx Oral Cleansing and Suctioning System ... QCare Rx Oral Cleansing and Suctioning System …
Matched Categories: … Antiseptics and Disinfectants ... Blood and Blood Forming Organs ... Blood Substitutes and Perfusion Solutions ... Mouthwashes and Gargles …
Matched Products: … SmartMouth Gum and Plaque Formula ... Qcare Oral Cleansing and Suctioning System ... Crest Pro-Health Gum and Breath Purify …
VOR33
VOR33 is an allogeneic CRISPR/Cas9 genome-edited hematopoietic stem and progenitor cell (HSPC) therapy product lacking the CD33 protein.
Investigational
Matched Synonyms: … allogeneic CRISPR/Cas9 genome-edited hematopoietic stem and progenitor cell (HSPC) therapy product lacking …
Matched Description: … VOR33 is an allogeneic CRISPR/Cas9 genome-edited hematopoietic stem and progenitor cell (HSPC) therapy …
Matched Description: … VOR33 is an allogeneic CRISPR/Cas9 genome-edited hematopoietic stem and progenitor cell (HSPC) therapy …
ARGX-119
ARGX-119 is a monoclonal antibody that targets and activates muscle-specific kinase (MuSK).
Investigational
Matched Synonyms: … humanized immunoglobulin gamma 1 (IgG1) agonistic monoclonal antibody (mAb) that specifically targets and …
Matched Description: … ARGX-119 is a monoclonal antibody that targets and activates muscle-specific kinase (MuSK). …
Matched Description: … ARGX-119 is a monoclonal antibody that targets and activates muscle-specific kinase (MuSK). …
Phenylephrine
Phenylephrine is an alpha-1 adrenergic receptor agonist used to treat hypotension,[L9416,L9410] dilate the pupil, and induce local vasoconstriction. The action of phenylephrine, or neo-synephrine, was first described in literature in the 1930s. Phenylephrine was granted FDA approval in 1939.
Approved
Matched Description: … alpha-1 adrenergic receptor agonist used to treat hypotension,[L9416,L9410] dilate the pupil,[L9413] and …
Matched Mixtures name: … Pulmo Calcio ... Promethazine HCl, Phenylephrine HCl and Codeine Phosphate ... Promethazine Hydrochloride, Phenylephrine Hydrochloride and Codeine Phosphate …
Matched Categories: … Adrenergic and Dopaminergic Agents ... Mydriatics and Cycloplegics ... Decongestants and Antiallergics ... phenylephrine and ketorolac …
Matched Products: … CareOne Cold and Sinus ... Up and Up Sinus PE ... Up and Up nasal decongestant PE …
Matched Mixtures name: … Pulmo Calcio ... Promethazine HCl, Phenylephrine HCl and Codeine Phosphate ... Promethazine Hydrochloride, Phenylephrine Hydrochloride and Codeine Phosphate …
Matched Categories: … Adrenergic and Dopaminergic Agents ... Mydriatics and Cycloplegics ... Decongestants and Antiallergics ... phenylephrine and ketorolac …
Matched Products: … CareOne Cold and Sinus ... Up and Up Sinus PE ... Up and Up nasal decongestant PE …
Displaying drugs 151 - 175 of 918 in total