Natriuretic Agents

Name
Natriuretic Agents
Accession Number
DBCAT000114
Description

Endogenous or exogenous chemicals that regulate the WATER-ELECTROLYTE BALANCE in the body. They consist of peptides and non-peptide compounds.

Drugs
DrugDrug Description
DesmopressinA synthetic analog of vasopressin used to reduce renal excretion of water in central diabetes insipidus and nocturia.
VasopressinA peptide hormone used to increase blood pressure in patients with vasodilatory shock who are resistant to fluid and catecholamine therapy.
TorasemideA diuretic used to treat hypertension and edema associated with heart failure, renal failure, or liver disease.
MethyclothiazideA diuretic drug used to treat hypertension and edema caused by heart failure, renal conditions, treatment with corticosteroids, and estrogen therapy.
ChlorthalidoneA diuretic used to treat hypertension or edema caused by heart failure, renal failure, hepatic cirrhosis, estrogen therapy, and other conditions.
EthoxzolamideFor use in the treatment of duodenal ulcers, as a diuretic, and in the treatment of glaucoma, and may also be useful in the treatment of seizures associated with epilepsy.
TriamtereneA potassium-sparing diuretic used in the treatment of edema and in the management of hypertension.
SpironolactoneAn aldosterone receptor antagonist used for the treatment of hypertension, hyperaldosteronism, edema due to various conditions, hirsutism (off-label) and hypokalemia.
BendroflumethiazideA diuretic used to suppress lactation and to treat hypertension and edema.
MetolazoneA thiazide-like diuretic used to treat hypertension.
AmilorideA pyrizine compound used to treat hypertension and congestive heart failure.
CyclothiazideCyclothiazide is indicated as adjunctive therapy in edema associated with congestive heart failure, hepatic cirrhosis, and corticosteroid and estrogen therapy. It is also indicated in the management of hypertension either...
FurosemideA loop diuretic used to treat hypertension and edema in congestive heart failure, liver cirrhosis, renal disease, and hypertension.
EplerenoneAn aldosterone receptor antagonist used to improve survival of patients with symptomatic heart failure and to reduce blood pressure.
MethazolamideA carbonic anhydrase inhibitor used to treat open angle glaucoma and acute angle closure glaucoma.
MannitolA sugar alcohol used to test for asthma, to reduce intracranial and intraocular pressure, and to measure glomerular filtration rate.
HydroflumethiazideA thiazide diuretic used to treat hypertension as well as edema due to congestive heart failure and liver cirrhosis.
IndapamideA thiazide diuretic used to treat hypertension as well as edema due to congestive heart failure.
AcetazolamideA carbonic anhydrase inhibitor used to treat edema from heart failure or medications, certain types of epilepsy, and glaucoma.
ConivaptanAn antidiuretic hormone inhibitor used to raise serum sodium levels.
ChlorothiazideA thiazide diuretic used to treat hypertension and edema in congestive heart failure, hepatic cirrhosis, and corticosteroid and estrogen therapy.
BumetanideA sulfamyl diuretic used to treat edema in congestive heart failure, hepatic and renal disease, and nephrotic syndrome.
Etacrynic acidA diuretic used to treat ascites and edema in congestive heart failure, liver cirrhosis, and renal disease.
HydrochlorothiazideA thiazide diuretic used to treat edema associated with a number of conditions, and hypertension.
TrichlormethiazideUsed in the treatment of oedema (including that associated with heart failure) and hypertension.
PolythiazideA thiazide diuretic used in the management of hypertension and treatment of edema.
QuinethazoneUsed to treat hypertension.
DrospirenoneA progestin used in oral contraceptive pills for the prevention of pregnancy and other conditions.
PiretanidePiretanide (INN, trade names Arelix, Eurelix, Tauliz) has been synthesized in 1973 at Hoechst AG (Germany) as a loop diuretic compound by using a then-new method for introducing cyclic amine...
Tienilic acidFor the treatment of hypertension.
NesiritideA recombinant natriuretic peptide used for the treatment of patients with acutely decompensated congestive heart failure who have dyspnea at rest or with minimal activity.
UlaritideInvestigated for use/treatment in congestive heart failure.
TolvaptanA selective vasopressin V2-receptor antagonist to slow kidney function decline in patients at risk for rapidly progressing autosomal dominant polycystic kidney disease (ADPKD). Also used to treat hypervolemic and euvolemic hyponatremia.
AzosemideAzosemide is a loop diuretic used to treat hypertension, edema, and ascites.
Canrenoic acidCanrenoic acid (as the salt potassium canrenoate) is an aldosterone antagonist. Like spironolactone, it is a prodrug, which is metabolized to canrenone in the body.
Potassium citrateAn agent used to manage renal tubular acidosis, hypocitraturic calcium oxalate nephrolithiasis, and uric acid lithiasis with or without calcium stones.
EfonidipineFor the treatment of hypertension.
IsosorbideA vasodilator used for the prevention and treatment of angina pectoris due to coronary artery disease.
CanrenoneCanrenone has been used in trials studying the diagnostic of Heart Failure.
RolofyllineRolofylline is under clinical development by pharmaceutical company NovaCardia for the treatment of congestive heart failure.
SpiradolineSpiradoline has been investigated for the basic science of Bipolar Depression.
CicletanineCicletanine is under investigation for the treatment of Diabetes, Hypokalemia, Hyponatremia, and Arterial Hypertension.
IbopamineNot Annotated
MefrusideNot Annotated
CyclopenthiazideCyclopenthiazide is a thiazide diuretic with antihypertensive properties. In a double blind, randomized crossover study, cyclopenthiazide was effective in reducing diastolic blood pressure in mildly hypertensive non-insulin dependent diabetic patients...
FenquizoneNot Annotated
ClopamideClopamide is an oral diuretic agent with antihypertensive activity. Like thiazide diuretics, it has an aromatic sulfonamide base but with no double-ring structure.
MuzolimineNot Annotated
XipamideNot Annotated
LypressinNot Annotated
SatavaptanSatavaptan is under investigation in clinical trial NCT00359437 (Satavaptan in the Prevention of Ascites Recurrence in Patients With Ascites Due to Cirrhosis of the Liver).
Drugs & Drug Targets
DrugTargetType
DesmopressinVasopressin V1a receptortarget
DesmopressinVasopressin V1b receptortarget
DesmopressinVasopressin V2 receptortarget
DesmopressinProstaglandin G/H synthase 1enzyme
DesmopressinProstaglandin G/H synthase 2enzyme
VasopressinVasopressin V1a receptortarget
VasopressinVasopressin V2 receptortarget
VasopressinVasopressin V1b receptortarget
VasopressinCanalicular multispecific organic anion transporter 1transporter
TorasemideSolute carrier family 12 member 1target
TorasemideCytochrome P450 2C8enzyme
TorasemideCytochrome P450 2C9enzyme
TorasemideSolute carrier organic anion transporter family member 1B1transporter
TorasemideSolute carrier family 12 member 2target
TorasemideSerum albumincarrier
MethyclothiazideSolute carrier family 12 member 1target
MethyclothiazideCarbonic anhydrase 4target
MethyclothiazideCarbonic anhydrase 2target
MethyclothiazideCarbonic anhydrase 1target
ChlorthalidoneSolute carrier family 12 member 1target
ChlorthalidoneSerum albumincarrier
ChlorthalidoneCarbonic anhydrase 1target
EthoxzolamideCarbonic anhydrase 1target
EthoxzolamideSolute carrier family 22 member 6transporter
EthoxzolamideCarbonic anhydrase 2target
EthoxzolamideCarbonic anhydrase 4target
EthoxzolamideCarbonic anhydrase 7target
EthoxzolamideCarbonic anhydrase 3target
TriamtereneAmiloride-sensitive sodium channel subunit gammatarget
TriamtereneAmiloride-sensitive sodium channel subunit alphatarget
TriamtereneAmiloride-sensitive sodium channel subunit betatarget
TriamtereneAmiloride-sensitive sodium channel subunit deltatarget
TriamtereneCytochrome P450 1A2enzyme
SpironolactoneMineralocorticoid receptortarget
SpironolactoneCytochrome P450 2C8enzyme
SpironolactoneCanalicular multispecific organic anion transporter 1transporter
SpironolactoneP-glycoprotein 1transporter
SpironolactoneSolute carrier organic anion transporter family member 1A2transporter
SpironolactoneCytochrome P450 11B1, mitochondrialenzyme
SpironolactoneAndrogen receptortarget
SpironolactoneProgesterone receptortarget
SpironolactoneGlucocorticoid receptortarget
SpironolactoneCytochrome P450 11B2, mitochondrialtarget
SpironolactoneSteroid 17-alpha-hydroxylase/17,20 lyasetarget
Spironolactone3-oxo-5-alpha-steroid 4-dehydrogenasetarget
SpironolactoneSex hormone-binding globulintarget
SpironolactoneVoltage-dependent calcium channeltarget
SpironolactoneNuclear receptor subfamily 1 group I member 2target
SpironolactoneBile salt export pumptransporter
SpironolactoneSerum albumincarrier
Spironolactonealpha1-acid glycoproteincarrier
BendroflumethiazideSolute carrier family 12 member 3target
BendroflumethiazideCarbonic anhydrase 1target
BendroflumethiazideCarbonic anhydrase 2target
BendroflumethiazideCarbonic anhydrase 4target
BendroflumethiazideCalcium-activated potassium channel subunit alpha-1target
BendroflumethiazideThiopurine S-methyltransferaseenzyme
MetolazoneSolute carrier family 12 member 3target
AmilorideAmiloride-sensitive sodium channel subunit betatarget
AmilorideAcid-sensing ion channel 1target
AmilorideAmiloride-sensitive amine oxidase [copper-containing]target
AmilorideAmiloride-sensitive sodium channel subunit alphatarget
AmilorideAmiloride-sensitive sodium channel subunit gammatarget
AmilorideSodium/hydrogen exchanger 1target
AmilorideAcid-sensing ion channel 2target
AmilorideAmiloride-sensitive sodium channel subunit deltatarget
AmilorideUrokinase-type plasminogen activatortarget
AmilorideSolute carrier family 22 member 2transporter
AmilorideSolute carrier family 22 member 4transporter
AmilorideAmiloride-sensitive amine oxidase [copper-containing]enzyme
AmilorideAmiloride-sensitive amine oxidase [copper-containing]enzyme
CyclothiazideSodium/potassium-transporting ATPase subunit gammatarget
CyclothiazideCarbonic anhydrase 1target
CyclothiazideCarbonic anhydrase 2target
CyclothiazideCarbonic anhydrase 4target
CyclothiazideSolute carrier family 22 member 6transporter
CyclothiazideSecreted frizzled-related protein 4target
FurosemideSolute carrier family 12 member 1target
FurosemideSerum albumincarrier
FurosemideSolute carrier family 22 member 6transporter
FurosemideSolute carrier family 22 member 5transporter
FurosemideSolute carrier family 22 member 8transporter
FurosemideCanalicular multispecific organic anion transporter 1transporter
FurosemideSolute carrier organic anion transporter family member 2A1transporter
FurosemideSolute carrier family 22 member 11transporter
Furosemide6-phosphogluconate dehydrogenase, decarboxylatingenzyme
FurosemideCarbonic anhydrase 2target
FurosemideUDP-glucuronosyltransferase 1-1enzyme
FurosemideThyroxine-binding globulincarrier
FurosemideG-protein coupled receptor 35target
EplerenoneMineralocorticoid receptortarget
EplerenoneCytochrome P450 3A4enzyme
EplerenoneCytochrome P450 3A5enzyme
EplerenoneCytochrome P450 11B2, mitochondrialenzyme
MethazolamideCarbonic anhydrase 1target
MethazolamideSolute carrier family 22 member 6transporter
MethazolamideCarbonic anhydrase 4target
MethazolamideCarbonic anhydrase 2target
MethazolamideCarbonic anhydrase 7target
MethazolamideCarbonic anhydrase 3target
MannitolMannitol dehydrogenaseenzyme
HydroflumethiazideSolute carrier family 12 member 1target
HydroflumethiazideSodium/potassium-transporting ATPase subunit alpha-1target
HydroflumethiazideCarbonic anhydrase 4target
HydroflumethiazideCalcium-activated potassium channel subunit alpha-1target
HydroflumethiazideCarbonic anhydrase 2target
HydroflumethiazideCarbonic anhydrase 1target
HydroflumethiazideCarbonic anhydrase 9target
HydroflumethiazideCarbonic anhydrase 12target
HydroflumethiazideSerum albumincarrier
HydroflumethiazideSolute carrier family 22 member 6transporter
HydroflumethiazideSolute carrier family 22 member 8transporter
HydroflumethiazideCarbonic anhydrase 7target
IndapamideCytochrome P450 3A4enzyme
IndapamideSolute carrier family 12 member 3target
AcetazolamideCarbonic anhydrase 1target
AcetazolamideAquaporin-1target
AcetazolamideCarbonic anhydrase 14target
AcetazolamideSolute carrier family 22 member 6transporter
AcetazolamideCarbonic anhydrase 2target
AcetazolamideCarbonic anhydrase 3target
AcetazolamideCarbonic anhydrase 4target
AcetazolamideCytochrome P450 3A4enzyme
AcetazolamideCarbonic anhydrase 7target
AcetazolamideCarbonic anhydrase 12target
ConivaptanVasopressin V1a receptortarget
ConivaptanVasopressin V2 receptortarget
ConivaptanCytochrome P450 3A4enzyme
ConivaptanP-glycoprotein 1transporter
ChlorothiazideSolute carrier family 12 member 3target
ChlorothiazideCarbonic anhydrase 1target
ChlorothiazideCarbonic anhydrase 2target
ChlorothiazideSolute carrier family 22 member 6transporter
BumetanideSolute carrier family 12 member 1target
BumetanideCystic fibrosis transmembrane conductance regulatortarget
BumetanideSolute carrier family 12 member 2target
BumetanideSolute carrier family 12 member 4target
BumetanideSolute carrier family 12 member 5target
BumetanideSodium/bile acid cotransportertransporter
BumetanideSolute carrier family 22 member 6transporter
BumetanideSolute carrier family 22 member 8transporter
BumetanideSolute carrier family 22 member 11transporter
BumetanideSolute carrier family 22 member 7transporter
BumetanideSolute carrier organic anion transporter family member 1A2transporter
BumetanideProstaglandin G/H synthase 2enzyme
Etacrynic acidSolute carrier family 12 member 1target
Etacrynic acidSodium/potassium-transporting ATPase subunit alpha-1target
Etacrynic acidGlutathione S-transferase A2enzyme
Etacrynic acidSerum albumincarrier
Etacrynic acidSolute carrier family 22 member 6transporter
Etacrynic acidLymphoid enhancer-binding factor 1target
Etacrynic acidGlutathione S-transferase Ptarget
HydrochlorothiazideSolute carrier family 12 member 3target
HydrochlorothiazideSolute carrier family 22 member 6transporter
HydrochlorothiazideCalcium-activated potassium channel subunit alpha-1target
HydrochlorothiazideSerum albumincarrier
HydrochlorothiazideSolute carrier family 22 member 11transporter
HydrochlorothiazideMultidrug resistance-associated protein 4transporter
HydrochlorothiazideSolute carrier family 22 member 8transporter
TrichlormethiazideSolute carrier family 12 member 3target
TrichlormethiazideSodium/potassium-transporting ATPase subunit alpha-1target
TrichlormethiazideCarbonic anhydrase 4target
TrichlormethiazideCarbonic anhydrase 2target
TrichlormethiazideCarbonic anhydrase 1target
TrichlormethiazideThiopurine S-methyltransferaseenzyme
PolythiazideSolute carrier family 12 member 3target
QuinethazoneCarbonic anhydrase 1target
QuinethazoneCarbonic anhydrase 2target
QuinethazoneSolute carrier family 12 member 1target
QuinethazoneSolute carrier family 12 member 2target
QuinethazoneSolute carrier family 12 member 3target
DrospirenoneProgesterone receptortarget
DrospirenoneMineralocorticoid receptortarget
DrospirenoneAndrogen receptortarget
DrospirenoneProstaglandin G/H synthase 2enzyme
DrospirenoneSerum paraoxonase/arylesterase 1enzyme
DrospirenoneGlucocorticoid receptortarget
DrospirenoneCytochrome P450 3A4enzyme
PiretanideSolute carrier family 12 member 1target
Tienilic acidCytochrome P450 2C9enzyme
NesiritideAtrial natriuretic peptide receptor 1target
NesiritideAtrial natriuretic peptide receptor 2target
NesiritideAtrial natriuretic peptide receptor 3target
UlaritideAtrial natriuretic peptide receptor 1target
TolvaptanVasopressin V2 receptortarget
TolvaptanCytochrome P450 3A4enzyme
TolvaptanP-glycoprotein 1transporter
TolvaptanVasopressin V1a receptortarget
EfonidipineVoltage-dependent T-type calcium channel subunit alpha-1Itarget
EfonidipineVoltage-dependent L-type calcium channel subunit alpha-1Ctarget
EfonidipineCytochrome P450 3A4enzyme
IsosorbideApoptosis regulator Bcl-2target
IsosorbideBcl-2-like protein 1target
IsosorbideInduced myeloid leukemia cell differentiation protein Mcl-1target
RolofyllineAdenosine receptor A1target
LypressinVasopressin V1a receptortarget
LypressinVasopressin V2 receptortarget
LypressinVasopressin V1b receptortarget
LypressinCanalicular multispecific organic anion transporter 1transporter