Polyamines

Name
Polyamines
Accession Number
DBCAT000281
Description

Amine compounds that consist of carbon chains or rings containing two or more primary amino groups.

Drugs
DrugDrug Description
Indium In-111 satumomab pendetideFor diagnosis of extrahepatic malignant cancers
SpermineFor nutritional supplementation, also for treating dietary shortage or imbalance
GadodiamideA gadolinium-based contrast agent used for the visualization of lesions with vascularity during magnetic resonance imaging (MRI) scans.
EthambutolAn antituberculosis agent used in the prophylaxis and treatment of tuberculosis (TB).
ColestipolA bile acid sequestrant used as an adjunct to diet and exercise to reduce LDL-C cholesterol levels in patients with primary hypercholesterolemia.
SevelamerA phosphate binder used to treat hyperphosphatemia.
Gadopentetic acidA gadolinium compound used as a contrast agent in MRIs.
TripelennamineA histamine H1 antagonist used to treat hypersensitivity reactions, coughs, and the common cold.
Edetic acidA chelating agent used to treat mercury and lead toxicity and some blood transfusion dependent anemias.
AminophyllineA bronchodilator consisting of theophylline that is used for the treatment of bronchospasm due to asthma, emphysema and chronic bronchitis.
PutrescinePutrescine is a toxic diamine formed by putrefaction from the decarboxylation of arginine and ornithine. Putrescine is a solid. This compound belongs to the polyamines. These are compounds containing more...
4,5-Dimethyl-1,2-phenylenediamineNot Available
Hexamethylene diamineNot Available
GlutathionylspermidineNot Available
TrypanothioneNot Available
SpermidineSpermidine is a polyamine formed from putrescine. It is found in almost all tissues in association with nucleic acids. It is found as a cation at all pH values, and...
OctamethylenediamineNot Available
MethapyrileneMethapyrilene, formerly marketed in many drug products, was shown to be a potent carcinogen. Manufacturers voluntarily withdrew methapyriline drug products from the market in May and June 1979.
EzogabineAn antiepileptic agent used as an adjuvant treatment of partial-onset seizures.
SQ-109Investigated for use/treatment in bacterial infection, infectious and parasitic disease (unspecified), and tuberculosis.
REP8839For the treatment of bacterial infections caused by susceptible microorganisms (Staphylococcus aureus, including methicillin-resistant S. aureus (MRSA), and Streptococcus pyogenes).
DP-b99Investigated for use/treatment in strokes and traumatic brain injuries.
TrodusquemineInvestigated for use/treatment in obesity and diabetes mellitus type 2.
DiethylnorspermineInvestigated for use/treatment in renal cell carcinoma, pancreatic cancer, melanoma, and lung cancer.
MangafodipirAn organ-specific paramagnetic contrast agent indicated for the imaging of the hepatobiliary system and detecting lesions in the liver and pancreas.
MethenamineA urinary tract antiseptic and antibacterial drug used for the prophylaxis and treatment of frequently recurring urinary tract infections requiring a long-term therapy.
TriethylenetetramineA copper chelating agent used for the management of Wilson's disease in cases where penicillamine therapy is clinically inappropriate.
ChloropyramineFor the treatment of allergic conjunctivitis, allergic rhinitis, bronchial asthma, and other atopic (allergic) conditions.
Gadoxetic acidA gadolinium-based contrast agent used in magnetic resonance imaging (MRI) to help characterize lesions in the liver.
AfuresertibAfuresertib has been used in trials studying the treatment of Cancer and Neoplasms, Haematologic.
UprosertibUprosertib has been used in trials studying the treatment of Cancer, Melanoma, Solid Tumours, Cervical Cancer, and HER2/Neu Negative, among others.
PentetreotidePentetreotide has been used in trials studying the diagnostic of cushing syndrome.
OlaflurOlaflur which is also referred to as elmex gel is an ingredient used in toothpaste which helps in the prevention of dental caries.
Sodium feredetateNot Annotated
TenitramineNot Annotated
Pentetic acidDTPA is widely used in industry and medicine. As a medical agent, it is approved for its use in medical imaging and for the decorporation of internally deposited radionuclides. It...
p-PhenylenediamineNot Annotated
EthylenediamineEthylenediamine is approved for use within allergenic epicutaneous patch tests which are indicated for use as an aid in the diagnosis of allergic contact dermatitis (ACD) in persons 6 years...
N,N'-diphenyl-1,4-phenylenediamineNot Annotated
4-(Isopropylamino)diphenylamine4-(Isopropylamino)diphenylamine is approved for use within allergenic epicutaneous patch tests which are indicated for use as an aid in the diagnosis of allergic contact dermatitis (ACD) in persons 6 years...
Quaternium-15Quaternium-15 is approved for use within allergenic epicutaneous patch tests which are indicated for use as an aid in the diagnosis of allergic contact dermatitis (ACD) in persons 6 years...
N-Cyclohexyl-N'-phenyl-1,4-phenylenediamineN-Cyclohexyl-N'-phenyl-1,4-phenylenediamine is approved for use within allergenic epicutaneous patch tests which are indicated for use as an aid in the diagnosis of allergic contact dermatitis (ACD) in persons 6 years...
CadaverineCadaverine is a foul-smelling diamine formed by bacterial decarboxylation of lysine.
MDL72527Not Available
Drugs & Drug Targets
DrugTargetType
Indium In-111 satumomab pendetideTumor-associated glycoprotein 72 (TAG-72)target
SpermineSpermine oxidasetarget
SpermineSpermine synthasetarget
SpermineOrnithine decarboxylasetarget
SpermineXanthine dehydrogenase/oxidaseenzyme
SpermineSolute carrier family 22 member 4transporter
SpermineSolute carrier family 22 member 1transporter
SpermineDNAtarget
SpermineDiamine acetyltransferase 1enzyme
SpermineDiamine acetyltransferase 2enzyme
SpermineExtracellular calcium-sensing receptortarget
SpermineBeta-1 adrenergic receptortarget
SpermineBeta-2 adrenergic receptortarget
EthambutolProbable arabinosyltransferase Btarget
EthambutolProbable arabinosyltransferase Atarget
EthambutolProbable arabinosyltransferase Ctarget
ColestipolBile acidstarget
SevelamerPhosphatetarget
Gadopentetic acid6-phosphogluconate dehydrogenase, decarboxylatingtarget
TripelennamineHistamine H1 receptortarget
TripelennamineCytochrome P450 2D6enzyme
Edetic acidLeadtarget
Edetic acidIrontarget
Edetic acidManganese cationtarget
Edetic acidAdenosine deaminaseenzyme
Edetic acidSerum paraoxonase/lactonase 3enzyme
Edetic acidCytochrome P450 19A1enzyme
AminophyllinecGMP-inhibited 3',5'-cyclic phosphodiesterase Atarget
AminophyllineAdenosine receptor A3target
AminophyllineAdenosine receptor A1target
AminophyllineCytochrome P450 1A2enzyme
AminophyllineCytochrome P450 2E1enzyme
AminophyllineCytochrome P450 3A4enzyme
AminophyllineHistone deacetylase 2target
PutrescineOrnithine decarboxylasetarget
PutrescineS-adenosylmethionine decarboxylase proenzymetarget
PutrescinePutrescine-binding periplasmic proteintarget
PutrescineSolute carrier family 22 member 4transporter
PutrescineBeta-1 adrenergic receptortarget
PutrescineBeta-2 adrenergic receptortarget
4,5-Dimethyl-1,2-phenylenediamineNicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferasetarget
Hexamethylene diamineAgmatinase, putativetarget
TrypanothioneTrypanothione reductasetarget
SpermidineThioredoxin reductase 1, cytoplasmictarget
SpermidineGentamicin 3'-acetyltransferasetarget
SpermidineSpermidine/putrescine-binding periplasmic proteintarget
SpermidineSolute carrier family 22 member 4transporter
SpermidineSolute carrier family 22 member 1transporter
SpermidineBeta-1 adrenergic receptortarget
SpermidineBeta-2 adrenergic receptortarget
EzogabinePotassium voltage-gated channel subfamily KQT member 2target
EzogabinePotassium voltage-gated channel subfamily KQT member 3target
EzogabinePotassium voltage-gated channel subfamily KQT member 4target
EzogabinePotassium voltage-gated channel subfamily KQT member 5target
EzogabineUDP-glucuronosyltransferase 1-1enzyme
EzogabineUDP-glucuronosyltransferase 1-3enzyme
EzogabineUDP-glucuronosyltransferase 1-4enzyme
EzogabineUDP-glucuronosyltransferase 1-9enzyme
EzogabineArylamine N-acetyltransferase 2enzyme
REP8839Methionine--tRNA ligasetarget
TrodusquemineTyrosine-protein phosphatase non-receptor type 1target
TrodusquemineSodium-dependent dopamine transportertarget
TrodusquemineSodium-dependent noradrenaline transportertarget
MangafodipirAlpha-2-macroglobulincarrier
MangafodipirSerum albumincarrier
MangafodipirSuperoxide dismutase [Mn], mitochondrialenzyme
MangafodipirNatural resistance-associated macrophage protein 2transporter
TriethylenetetramineGlypican-1transporter
ChloropyramineHistamine H1 receptortarget
Gadoxetic acidSolute carrier organic anion transporter family member 1B1transporter
Gadoxetic acidSolute carrier organic anion transporter family member 1B3transporter
Gadoxetic acidCanalicular multispecific organic anion transporter 2transporter
Gadoxetic acidCanalicular multispecific organic anion transporter 1transporter
Gadoxetic acidMultidrug resistance-associated protein 4transporter
Pentetic acidTransuranium elementstarget
Pentetic acidAlpha-1-antitrypsincarrier
Cadaverine2-C-methyl-D-erythritol 4-phosphate cytidylyltransferasetarget
MDL72527Spermine oxidasetarget