Edetate calcium disodium

This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.

Identification

Name
Edetate calcium disodium anhydrous
Commonly known or available as Edetate calcium disodium
Accession Number
DB14598  (DBSALT000837)
Type
Small Molecule
Groups
Approved
Description
Not Available
Structure
Thumb
Synonyms
  • Edetate calcium disodium (anhydrous)
Product Ingredients
IngredientUNIICASInChI Key
Edetate calcium disodium25IH6R4SGF6766-87-6JCQNARRMQCMKAN-UHFFFAOYSA-J
Active Moieties
NameKindUNIICASInChI Key
Edetic Acidunknown9G34HU7RV060-00-4KCXVZYZYPLLWCC-UHFFFAOYSA-N
Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Calcium Disodium VersenateInjection200 mg/1mLIntramuscularGraceway Pharmaceuticals, LLC2009-07-092015-12-31Us
Calcium Disodium VersenateInjection200 mg/1mLIntramuscular; IntravenousMedicis Pharmaceutical Corp2013-06-21Not applicableUs
Calcium Disodium VersenateInjection200 mg/1mLIntramuscular3M Pharmaceuticals2009-07-092015-12-31Us
Calcium Disodium VersenateInjection200 mg/1mLIntramuscularGraceway Pharmaceuticals, LLC2009-07-092007-09-19Us
Categories
UNII
8U5D034955
CAS number
62-33-9
Weight
Average: 374.268
Monoisotopic: 374.001495875
Chemical Formula
C10H12CaN2Na2O8
InChI Key
SHWNNYZBHZIQQV-UHFFFAOYSA-J
InChI
InChI=1S/C10H16N2O8.Ca.2Na/c13-7(14)3-11(4-8(15)16)1-2-12(5-9(17)18)6-10(19)20;;;/h1-6H2,(H,13,14)(H,15,16)(H,17,18)(H,19,20);;;/q;+2;2*+1/p-4
IUPAC Name
calcium disodium 2-({2-[bis(carboxymethyl)amino]ethyl}(carboxymethyl)amino)acetate
SMILES
[Na+].[Na+].[Ca++].[O-]C(=O)CN(CCN(CC([O-])=O)CC([O-])=O)CC([O-])=O

Pharmacology

Indication
Not Available
Pharmacodynamics
Not Available
Mechanism of action
Not Available
Absorption
Not Available
Volume of distribution
Not Available
Protein binding
Not Available
Metabolism
Not Available
Route of elimination
Not Available
Half life
Not Available
Clearance
Not Available
Toxicity
Not Available
Affected organisms
Not Available
Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
DrugInteraction
(1,2,6,7-3H)TestosteroneThe therapeutic efficacy of Edetate calcium disodium anhydrous can be increased when used in combination with (1,2,6,7-3H)Testosterone.
(R)-warfarinThe risk or severity of bleeding can be increased when (R)-warfarin is combined with Edetate calcium disodium anhydrous.
(S)-WarfarinThe risk or severity of bleeding can be increased when (S)-Warfarin is combined with Edetate calcium disodium anhydrous.
1-TestosteroneThe therapeutic efficacy of Edetate calcium disodium anhydrous can be increased when used in combination with 1-Testosterone.
18-methyl-19-nortestosteroneThe therapeutic efficacy of Edetate calcium disodium anhydrous can be increased when used in combination with 18-methyl-19-nortestosterone.
4-hydroxycoumarinThe risk or severity of bleeding can be increased when 4-hydroxycoumarin is combined with Edetate calcium disodium anhydrous.
4-HydroxytestosteroneThe therapeutic efficacy of Edetate calcium disodium anhydrous can be increased when used in combination with 4-Hydroxytestosterone.
5beta-dihydrotestosteroneThe therapeutic efficacy of Edetate calcium disodium anhydrous can be increased when used in combination with 5beta-dihydrotestosterone.
AbciximabThe risk or severity of bleeding can be increased when Abciximab is combined with Edetate calcium disodium anhydrous.
AceclofenacThe risk or severity of bleeding and hemorrhage can be increased when Aceclofenac is combined with Edetate calcium disodium anhydrous.
Food Interactions
Not Available

References

General References
Not Available
External Links
PubChem Compound
6109
ChemSpider
5883
ChEBI
4757
ChEMBL
CHEMBL1200375
Wikipedia
Sodium_calcium_edetate

Clinical Trials

Clinical Trials
Not Available

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage forms
FormRouteStrength
InjectionIntramuscular200 mg/1mL
InjectionIntramuscular; Intravenous200 mg/1mL
Prices
Not Available
Patents
Not Available

Properties

State
Not Available
Experimental Properties
Not Available
Predicted Properties
PropertyValueSource
Water Solubility23.1 mg/mLALOGPS
logP0.03ALOGPS
logP-4.9ChemAxon
logS-1.3ALOGPS
pKa (Strongest Acidic)2.35ChemAxon
pKa (Strongest Basic)7.73ChemAxon
Physiological Charge-3ChemAxon
Hydrogen Acceptor Count10ChemAxon
Hydrogen Donor Count0ChemAxon
Polar Surface Area167 Å2ChemAxon
Rotatable Bond Count11ChemAxon
Refractivity105.69 m3·mol-1ChemAxon
Polarizability24.74 Å3ChemAxon
Number of Rings0ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterNoChemAxon
Veber's RuleNoChemAxon
MDDR-like RuleNoChemAxon
Predicted ADMET features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
Not Available

Taxonomy

Description
This compound belongs to the class of organic compounds known as tetracarboxylic acids and derivatives. These are carboxylic acids containing exactly four carboxyl groups.
Kingdom
Organic compounds
Super Class
Organic acids and derivatives
Class
Carboxylic acids and derivatives
Sub Class
Tetracarboxylic acids and derivatives
Direct Parent
Tetracarboxylic acids and derivatives
Alternative Parents
Alpha amino acids / Trialkylamines / Carboxylic acid salts / Amino acids / Organic calcium salts / Carboxylic acids / Organopnictogen compounds / Organic zwitterions / Organic sodium salts / Organic oxides
show 2 more
Substituents
Tetracarboxylic acid or derivatives / Alpha-amino acid / Alpha-amino acid or derivatives / Amino acid or derivatives / Carboxylic acid salt / Tertiary amine / Tertiary aliphatic amine / Amino acid / Carboxylic acid / Organic alkali metal salt
show 14 more
Molecular Framework
Aliphatic acyclic compounds
External Descriptors
Not Available

Drug created on August 25, 2018 09:50 / Updated on November 02, 2018 09:16