Protein Synthesis Inhibitors

Compounds which inhibit the synthesis of proteins. They are usually ANTI-BACTERIAL AGENTS or toxins. Mechanism of the action of inhibition includes the interruption of peptide-chain elongation, the blocking the A site of ribosomes, the misreading of the genetic code or the prevention of the attachment of oligosaccharide side chains to glycoproteins.
DrugDrug NameDrug Description
DB00199ErythromycinA macrolide antibiotic used to treat and prevent a variety of bacterial infections.
DB00314CapreomycinAn aminoglycoside antibiotic used as an adjunct drug in tuberculosis.
DB00410MupirocinAn antibacterial ointment used to treat impetigo and secondary skin infections caused by Staphylococcus aureus and Streptococcus pyogenes.
DB00446ChloramphenicolA broad spectrum antibiotic that is effective against a variety of susceptible and serious bacterial infections but is not frequently used because of its high risk of bone marrow toxicity.
DB00601LinezolidAn oxazolidinone antibiotic used to treat susceptible strains of multidrug resistant bacterial infections.
DB00759TetracyclineAn antibiotic used to treat a wide variety of susceptible infections.
DB00798GentamicinAn aminoglycoside used to treat a wide variety of infections in the body.
DB00955NetilmicinAn aminoglycoside used to treat a wide variety of infections in the body.
DB00970DactinomycinAn actinomycin used to treat a wide variety of cancers.
DB00976TelithromycinAn ketolide used to treat community acquired pneumonia of mild to moderate severity.
DB00994NeomycinAn aminoglycoside used to treat a wide variety of infections in the body.
DB01082StreptomycinAn aminoglycoside antibiotic indicated to treat mycobacterium tuberculosis and various non-tuberculosis infections.
DB01172KanamycinAn aminoglycoside antibiotic agent used in the treatment of various infections caused by susceptible bacteria.
DB01190ClindamycinAn antibiotic used to treat serious infections caused by susceptible anaerobic bacteria, such as intra-abdominal or pelvic infections, osteomyelitis, diabetic foot ulcers, and dental infections.
DB01211ClarithromycinA macrolide antibiotic used for the treatment of a wide variety of bacterial infections such as acute otitis, pharyngitis, tonsillitis, respiratory tract infections, uncomplicated skin infections, and helicobacter pylori infection.
DB01627LincomycinAn antibiotic indicated only for the treatment of serious infections, and is typically reserved for use in cases of penicillin allergy or where penicillin is inappropriate.
DB02703Fusidic acidA topical antibacterial agent used to prevent and treat mild to moderate skin infections caused by susceptible bacteria.
DB04222SparsomycinAn antitumor antibiotic produced by Streptomyces sparsogenes. It inhibits protein synthesis in 70S and 80S ribosomal systems. [PubChem]
DB04866HalofuginoneFor the treatment of scleroderma, cancer, and restenosis.
DB04950RanpirnaseFor the treatment of various forms of cancer.
DB06419CethromycinInvestigated for use/treatment in bacterial infection, pediatric indications, and pneumonia.
DB06810PlicamycinFor the treatment of testicular cancer, as well as hypercalcemia and hypercalciuria associated with a variety of advanced forms of cancer.
DB06827ViomycinViomycin is an essential component in the drug cocktail currently used to fight infections of Mycobacterium tuberculosis.
DB07348Brefeldin AA metabolite from Penicillium brefeldianum that exhibits a wide range of antibiotic activity.
DB07374AnisomycinAnisomycin (sometimes known as flagecidin), is an antibiotic retrieved from the bacteria Streptomyces griseolus. This drug acts to inhibit bacterial protein and DNA synthesis.
DB08437PuromycinPuromycin is an antibiotic that prevents bacterial protein translation. It is utilized as a selective agent in laboratory cell cultures. Puromycin is toxic to both prokaryotic and eukaryotic cells, resulting...
DB09093ChlortetracyclineThe first tetracycline antibiotic most commonly used for veterinary purposes.
DB11476VirginiamycinVirginiamycin is a streptogramin antibiotic similar to pristinamycin and quinupristin/dalfopristin. It is a combination of pristinamycin IIA and virginiamycin S1. Virginiamycin is used in the fuel ethanol industry to prevent...
DB12449TempolTempol has been used in trials studying the treatment of Anal Cancer.
DB12604SisomicinSisomicin has been used in trials studying the treatment of Pyoderma.
DB13393EmetineNot Annotated
DB01188CiclopiroxA broad-spectrum topical antifungal agent used to treat mild to moderate onychomycosis of fingernails and toenails in immunocompetent patients.
DB09041TavaboroleAn antifungal agent used to treat onychomycosis, a fungal infection of the nail.
DB00560TigecyclineA glycylcycline antibiotic used to treat a number of susceptible bacterial infections.
DB04865Omacetaxine mepesuccinateA cephalotaxine used in the treatment of Chronic Myeloid Leukemia (CML) that is intolerant to or resistant to two or more tyrosine kinase inhibitors.
DB12739BindaritBindarit has been used in trials studying the prevention and treatment of Coronary Restenosis and Diabetic Nephropathy.
DB13077LCB01-0371Lcb01 0371 is under investigation in clinical trial NCT01554995 (A Clinical Study, Randomized, Double-blind, Placebo-controlled, Single Dose Study).
DB15215KRN-5500KRN-5500 is under investigation in clinical trial NCT00002923 (KRN5500 in Treating Patients With Metastatic Solid Tumors).
DrugDrug NameTargetType
DB00199Erythromycin23S ribosomal RNAtarget
DB00199ErythromycinCytochrome P450 3A4enzyme
DB00199ErythromycinCytochrome P450 3A7enzyme
DB00199ErythromycinP-glycoprotein 1transporter
DB00199ErythromycinSolute carrier organic anion transporter family member 1B1transporter
DB00199ErythromycinMotilin receptortarget
DB00199ErythromycinPotassium voltage-gated channel subfamily H member 2target
DB00199ErythromycinCytochrome P450 3A5enzyme
DB00199ErythromycinSolute carrier organic anion transporter family member 1B3transporter
DB00199ErythromycinBile salt export pumptransporter
DB00199ErythromycinCanalicular multispecific organic anion transporter 1transporter
DB00199ErythromycinSolute carrier organic anion transporter family member 1A2transporter
DB00314Capreomycin16S/23S rRNA (cytidine-2'-O)-methyltransferase TlyAtarget
DB00410MupirocinIsoleucine--tRNA ligasetarget
DB00446ChloramphenicolComplement decay-accelerating factortarget
DB00446ChloramphenicolDr hemagglutinin structural subunittarget
DB00446ChloramphenicolCytochrome P450 2C19enzyme
DB00446ChloramphenicolCytochrome P450 3A4enzyme
DB00446ChloramphenicolCytochrome P450 3A5enzyme
DB00446ChloramphenicolCytochrome P450 3A7enzyme
DB00446ChloramphenicolSolute carrier family 22 member 6transporter
DB00446Chloramphenicol50S ribosomal protein L16target
DB00446ChloramphenicolChloramphenicol acetyltransferase 3enzyme
DB00446ChloramphenicolChloramphenicol acetyltransferaseenzyme
DB00446ChloramphenicolChloramphenicol 3-O phosphotransferaseenzyme
DB00601Linezolid23S ribosomal RNAtarget
DB00601LinezolidAmine oxidase [flavin-containing] Aenzyme
DB00601LinezolidAmine oxidase [flavin-containing] Benzyme
DB00759Tetracycline16S ribosomal RNAtarget
DB00759TetracyclineMajor prion proteintarget
DB00759TetracyclineSerum albumincarrier
DB00759TetracyclineCytochrome P450 3A4enzyme
DB00759TetracyclineSolute carrier family 22 member 6transporter
DB00759TetracyclineSolute carrier family 22 member 8transporter
DB00759TetracyclineSolute carrier family 22 member 11transporter
DB00759TetracyclineSolute carrier family 22 member 7transporter
DB00759Tetracycline30S ribosomal protein S3target
DB00759Tetracycline30S ribosomal protein S8target
DB00759Tetracycline30S ribosomal protein S19target
DB00759Tetracycline30S ribosomal protein S14target
DB00759Tetracycline30S ribosomal protein S7target
DB00759TetracyclineMultidrug translocase MdfAtarget
DB00759TetracyclineProtein-arginine deiminase type-4target
DB00759TetracyclineSolute carrier organic anion transporter family member 2B1transporter
DB00798Gentamicin30S ribosomal protein S12target
DB00798Gentamicin16S ribosomal RNAtarget
DB00798GentamicinLow-density lipoprotein receptor-related protein 2target
DB00798GentamicinSolute carrier family 22 member 6transporter
DB00798GentamicinNH(3)-dependent NAD(+) synthetasetarget
DB00798GentamicinDihydrofolate reductasetarget
DB00955Netilmicin30S ribosomal protein S12target
DB00955Netilmicin16S ribosomal RNAtarget
DB00970DactinomycinDNAtarget
DB00970DactinomycinSolute carrier family 22 member 5transporter
DB00970DactinomycinP-glycoprotein 1transporter
DB00970DactinomycinMultidrug resistance-associated protein 6transporter
DB00970DactinomycinMultidrug resistance-associated protein 1transporter
DB00970DactinomycinATP-binding cassette sub-family G member 2transporter
DB00970DactinomycinDNA topoisomerase 2target
DB00976Telithromycin23S ribosomal RNAtarget
DB00976TelithromycinCytochrome P450 3A4enzyme
DB00976TelithromycinSolute carrier organic anion transporter family member 1B1transporter
DB00976TelithromycinSolute carrier organic anion transporter family member 1B3transporter
DB00994Neomycin30S ribosomal protein S12target
DB00994Neomycin16S ribosomal RNAtarget
DB00994NeomycinExtracellular calcium-sensing receptortarget
DB01082Streptomycin30S ribosomal protein S12target
DB01082Streptomycin16S ribosomal RNAtarget
DB01082StreptomycinSolute carrier family 22 member 6transporter
DB01082StreptomycinProtein-arginine deiminase type-4target
DB01172Kanamycin30S ribosomal protein S12target
DB01172Kanamycin16S ribosomal RNAtarget
DB01172KanamycinAminoglycoside 2'-N-acetyltransferaseenzyme
DB01172KanamycinKanamycin nucleotidyltransferaseenzyme
DB01172KanamycinAminoglycoside 3'-phosphotransferaseenzyme
DB01190Clindamycin50S ribosomal protein L10target
DB01190ClindamycinCytochrome P450 3A4enzyme
DB01190Clindamycin23S ribosomal RNAtarget
DB01211Clarithromycin50S ribosomal protein L10target
DB01211ClarithromycinCytochrome P450 3A4enzyme
DB01211ClarithromycinCytochrome P450 3A5enzyme
DB01211ClarithromycinP-glycoprotein 1transporter
DB01211ClarithromycinSolute carrier family 22 member 7transporter
DB01211ClarithromycinPotassium voltage-gated channel subfamily H member 2target
DB01211ClarithromycinSolute carrier organic anion transporter family member 1B1target
DB01211ClarithromycinSolute carrier organic anion transporter family member 1B3target
DB01211ClarithromycinBile salt export pumptransporter
DB01627Lincomycin50S ribosomal protein L10target
DB02703Fusidic acidChloramphenicol acetyltransferase 3target
DB02703Fusidic acidChloramphenicol acetyltransferasetarget
DB02703Fusidic acidBile salt export pumptransporter
DB02703Fusidic acidCanalicular multispecific organic anion transporter 1transporter
DB02703Fusidic acidElongation factor Gtarget
DB02703Fusidic acidCytochrome P450 2D6enzyme
DB02703Fusidic acidCytochrome P450 3A4enzyme
DB02703Fusidic acidUDP-glucuronosyltransferase 1-1enzyme
DB02703Fusidic acidATP-binding cassette sub-family G member 2transporter
DB02703Fusidic acidSolute carrier organic anion transporter family member 1B1transporter
DB04866HalofuginoneCollagen alpha-1(I) chaintarget
DB04866Halofuginone72 kDa type IV collagenasetarget
DB04950RanpirnaseDNAtarget
DB06419Cethromycin23S ribosomal RNAtarget
DB06419CethromycinCytochrome P450 3A5enzyme
DB06419CethromycinCytochrome P450 3A4enzyme
DB06810PlicamycinDNAtarget
DB06827Viomycin16S/23S rRNA (cytidine-2'-O)-methyltransferase TlyAtarget
DB07348Brefeldin ACytohesin-2target
DB07348Brefeldin AADP-ribosylation factor 1target
DB07348Brefeldin ACytochrome P450 3A4enzyme
DB07374Anisomycin60S ribosomal protein L10-liketarget
DB07374Anisomycin60S ribosomal protein L13atarget
DB07374Anisomycin60S ribosomal protein L23target
DB07374Anisomycin60S ribosomal protein L15target
DB07374Anisomycin60S ribosomal protein L19target
DB07374Anisomycin60S ribosomal protein L23atarget
DB07374AnisomycinProbable ribosome biogenesis protein RLP24target
DB07374Anisomycin60S ribosomal protein L26-like 1target
DB07374Anisomycin60S ribosomal protein L8target
DB07374Anisomycin60S ribosomal protein L37target
DB07374Anisomycin60S ribosomal protein L3target
DB07374Anisomycin60S ribosomal protein L11target
DB07374AnisomycinNHP2-like protein 1target
DB08437Puromycin60S ribosomal protein L10-liketarget
DB08437Puromycin60S ribosomal protein L13atarget
DB08437Puromycin60S ribosomal protein L23target
DB08437Puromycin60S ribosomal protein L15target
DB08437Puromycin60S ribosomal protein L19target
DB08437Puromycin60S ribosomal protein L23atarget
DB08437PuromycinProbable ribosome biogenesis protein RLP24target
DB08437Puromycin60S ribosomal protein L26-like 1target
DB08437Puromycin60S ribosomal protein L8target
DB08437Puromycin60S ribosomal protein L37target
DB08437Puromycin60S ribosomal protein L3target
DB08437Puromycin60S ribosomal protein L11target
DB08437PuromycinLeucyl/phenylalanyl-tRNA--protein transferasetarget
DB09093Chlortetracycline16S ribosomal RNAtarget
DB09093ChlortetracyclineSerum albumincarrier
DB09093Chlortetracycline30S ribosomal protein S3target
DB09093Chlortetracycline30S ribosomal protein S8target
DB09093Chlortetracycline30S ribosomal protein S19target
DB09093Chlortetracycline30S ribosomal protein S14target
DB09093Chlortetracycline30S ribosomal protein S7target
DB01188CiclopiroxSodium/potassium-transporting ATPase subunit alpha-1target
DB09041TavaboroleCytosolic leucyl-tRNA synthetasetarget
DB00560Tigecycline30S ribosomal protein S9target
DB00560Tigecycline16S ribosomal RNAtarget
DB00560Tigecycline30S ribosomal protein S14target
DB00560Tigecycline30S ribosomal protein S13target
DB00560Tigecycline30S ribosomal protein S19target
DB00560Tigecycline30S ribosomal protein S12target
DB04865Omacetaxine mepesuccinate50S ribosomal protein L2target
DB04865Omacetaxine mepesuccinate60S ribosomal protein L3target