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Identification
NameTelithromycin
Accession NumberDB00976  (APRD00483)
TypeSmall Molecule
GroupsApproved
DescriptionTelithromycin, a semi-synthetic erythromycin derivative, belongs to a new chemical class of antibiotics called ketolides. Ketolides have been recently added to the macrolide-lincosamide-streptogramin class of antibiotics. Similar to the macrolide antibiotics, telithromycin prevents bacterial growth by interfering with bacterial protein synthesis. Telithromycin binds to the 50S subunit of the 70S bacterial ribosome and blocks further peptide elongation. Binding occurs simultaneously at to two domains of 23S RNA of the 50S ribosomal subunit, domain II and V, where older macrolides bind only to one. It is used to treat mild to moderate respiratory infections.
Structure
Thumb
SynonymsNot Available
External Identifiers
  • HMR 3647
Approved Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
KetekTablet, film coated300 mg/1OralSanofi Aventis U.S. Llc2010-06-01Not applicableUs
KetekTablet, film coated400 mg/1OralSanofi Aventis U.S. Llc2010-06-01Not applicableUs
KetekTablet, film coated400 mg/1OralPhysicians Total Care, Inc.2004-10-27Not applicableUs
KetekTablet400 mgOralSanofi Aventis Canada Inc2003-05-292011-08-15Canada
Approved Generic Prescription ProductsNot Available
Approved Over the Counter ProductsNot Available
Unapproved/Other Products Not Available
International BrandsNot Available
Brand mixturesNot Available
SaltsNot Available
Categories
UNIIKI8H7H19WL
CAS number191114-48-4
WeightAverage: 812.018
Monoisotopic: 811.473143313
Chemical FormulaC43H65N5O10
InChI KeyLJVAJPDWBABPEJ-PNUFFHFMSA-N
InChI
InChI=1S/C43H65N5O10/c1-12-33-43(8)37(48(41(53)58-43)19-14-13-18-47-23-31(45-24-47)30-16-15-17-44-22-30)27(4)34(49)25(2)21-42(7,54-11)38(28(5)35(50)29(6)39(52)56-33)57-40-36(51)32(46(9)10)20-26(3)55-40/h15-17,22-29,32-33,36-38,40,51H,12-14,18-21H2,1-11H3/t25-,26-,27+,28+,29-,32+,33-,36-,37-,38-,40+,42-,43-/m1/s1
IUPAC Name
(3aS,4R,7R,9R,10R,11R,13R,15R,15aR)-10-{[(2S,3R,4S,6R)-4-(dimethylamino)-3-hydroxy-6-methyloxan-2-yl]oxy}-4-ethyl-11-methoxy-3a,7,9,11,13,15-hexamethyl-1-{4-[4-(pyridin-3-yl)-1H-imidazol-1-yl]butyl}-tetradecahydro-1H-oxacyclotetradeca[4,3-d][1,3]oxazole-2,6,8,14-tetrone
SMILES
[H][C@@]12[C@@H](C)C(=O)[[email protected]](C)C[C@@](C)(OC)[[email protected]](O[C@@H]3O[[email protected]](C)C[C@@H]([[email protected]]3O)N(C)C)[C@@H](C)C(=O)[C@@H](C)C(=O)O[[email protected]](CC)[C@@]1(C)OC(=O)N2CCCCN1C=NC(=C1)C1=CC=CN=C1
Pharmacology
IndicationFor the treatment of Pneumococcal infection, acute sinusitis, acute bacterial tonsillitis, acute bronchitis and bronchiolitis, lower respiratory tract infection and lobar (pneumococcal) pneumonia.
Structured Indications
PharmacodynamicsTelithromycin is a ketolide antibiotic which has an antimicrobial spectrum similar or slightly broader than that of penicillin. It is often used as an alternative in patients who have an allergy to penicillins. For respiratory tract infections, it has better coverage of atypical organisms, including mycoplasma. Telithromycin prevents bacterial growth by binding to bacterial 50S ribosomal subunits and interfering with bacterial peptide translocation and elongation.
Mechanism of actionTelithromycin acts by binding to domains II and V of 23S rRNA of the 50S ribosomal subunit. By binding at domain II, telithromycin retains activity against gram-positive cocci (e.g. Streptococcus pneumoniae) in the presence of resistance mediated by methylases (erm genes) that alter the binding site at domain V. Telithromycin may also inhibit the assembly of nascent ribosomal units. Compared to erythromycin A, telithromycin binds to the 23S rRNA with 10 times greater affinity in erythromycin-susceptible organisms and 25 times greater affinity in macrolide-resistant strains. This increased binding affinity may be conferred by the C11-12 carbamate side chain of telithromycin. The side chain appears to maintain binding at domain II in the presence of resistance mediated by alterations in domain V.
TargetKindPharmacological actionActionsOrganismUniProt ID
23S rRNANucleotideyes
inhibitor
Enteric bacteria and other eubacterianot applicabledetails
Related Articles
AbsorptionAbsolute bioavailability is approximately 57%. Maximal concentrations are reached 0.5 - 4 hours following oral administration. Food intake does not affected absorption.
Volume of distribution
  • 2.9 L/kg
Protein binding60 - 70% bound primarily to human serum albumin
Metabolism

Hepatic - estimated 50% metabolized by CYP3A4 and 50% metabolized independent of cytochrome P450

Route of eliminationThe systemically available telithromycin is eliminated by multiple pathways as follows: 7% of the dose is excreted unchanged in feces by biliary and/or intestinal secretion; 13% of the dose is excreted unchanged in urine by renal excretion; and 37% of the dose is metabolized by the liver.
Half lifeMain elimination half-life is 2-3 hours; terminal elimination half-life is 10 hours
ClearanceNot Available
ToxicityLD50>2000 mg/kg (PO in rats). Adverse effects are similar to those of clarithormycin and erithromycin and include diarrhea, nausea, vomiting, loose stools, abdominal pain, flatulence and dyspepsia. It may also cause dizziness, headache and taste disturbances.
Affected organisms
  • Enteric bacteria and other eubacteria
Pathways
PathwayCategorySMPDB ID
Telithromycin Action PathwayDrug actionSMP00252
SNP Mediated EffectsNot Available
SNP Mediated Adverse Drug ReactionsNot Available
Interactions
Drug Interactions
DrugInteractionDrug group
16-BromoepiandrosteroneThe serum concentration of 16-Bromoepiandrosterone can be increased when it is combined with Telithromycin.Investigational
19-norandrostenedioneThe serum concentration of 19-norandrostenedione can be increased when it is combined with Telithromycin.Experimental, Illicit
4-AndrostenedioneThe serum concentration of 4-Androstenedione can be increased when it is combined with Telithromycin.Experimental, Illicit
5-androstenedioneThe serum concentration of 5-androstenedione can be increased when it is combined with Telithromycin.Experimental, Illicit
AbirateroneThe serum concentration of Telithromycin can be increased when it is combined with Abiraterone.Approved
AcenocoumarolThe metabolism of Acenocoumarol can be decreased when combined with Telithromycin.Approved
AcetaminophenThe metabolism of Acetaminophen can be decreased when combined with Telithromycin.Approved
AcetyldigitoxinThe serum concentration of Acetyldigitoxin can be increased when it is combined with Telithromycin.Approved
AdinazolamThe metabolism of Adinazolam can be decreased when combined with Telithromycin.Approved
AlbendazoleThe metabolism of Albendazole can be decreased when combined with Telithromycin.Approved, Vet Approved
AlclometasoneThe metabolism of Alclometasone can be decreased when combined with Telithromycin.Approved
AldosteroneThe serum concentration of Aldosterone can be increased when it is combined with Telithromycin.Experimental
AlfentanilThe serum concentration of Alfentanil can be increased when it is combined with Telithromycin.Approved, Illicit
AlfuzosinThe serum concentration of Alfuzosin can be increased when it is combined with Telithromycin.Approved, Investigational
AliskirenThe metabolism of Aliskiren can be decreased when combined with Telithromycin.Approved, Investigational
AllylestrenolThe metabolism of Allylestrenol can be decreased when combined with Telithromycin.Approved
AlmotriptanThe serum concentration of Almotriptan can be increased when it is combined with Telithromycin.Approved, Investigational
AlogliptinThe metabolism of Alogliptin can be decreased when combined with Telithromycin.Approved
AlosetronThe serum concentration of Alosetron can be increased when it is combined with Telithromycin.Approved, Withdrawn
AlprazolamThe serum concentration of Alprazolam can be increased when it is combined with Telithromycin.Approved, Illicit, Investigational
AmantadineAmantadine may increase the QTc-prolonging activities of Telithromycin.Approved
AmbrisentanThe metabolism of Ambrisentan can be decreased when combined with Telithromycin.Approved, Investigational
AmbroxolThe metabolism of Ambroxol can be decreased when combined with Telithromycin.Approved
AmcinonideThe serum concentration of Amcinonide can be increased when it is combined with Telithromycin.Approved
AminophenazoneThe metabolism of Aminophenazone can be decreased when combined with Telithromycin.Approved, Withdrawn
AminophyllineThe metabolism of Aminophylline can be decreased when combined with Telithromycin.Approved
AmiodaroneTelithromycin may increase the QTc-prolonging activities of Amiodarone.Approved, Investigational
AmitriptylineThe metabolism of Amitriptyline can be decreased when combined with Telithromycin.Approved
AmlodipineThe metabolism of Amlodipine can be decreased when combined with Telithromycin.Approved
AmoxapineAmoxapine may increase the QTc-prolonging activities of Telithromycin.Approved
AmprenavirThe metabolism of Amprenavir can be decreased when combined with Telithromycin.Approved
AmrinoneThe metabolism of Amrinone can be decreased when combined with Telithromycin.Approved
AnagrelideTelithromycin may increase the QTc-prolonging activities of Anagrelide.Approved
AnecortaveThe serum concentration of Anecortave can be increased when it is combined with Telithromycin.Investigational
AntipyrineThe metabolism of Antipyrine can be decreased when combined with Telithromycin.Approved
AnvirzelThe serum concentration of Anvirzel can be increased when it is combined with Telithromycin.Investigational
ApixabanThe serum concentration of Apixaban can be increased when it is combined with Telithromycin.Approved
ApomorphineApomorphine may increase the QTc-prolonging activities of Telithromycin.Approved, Investigational
ApremilastThe metabolism of Apremilast can be decreased when combined with Telithromycin.Approved, Investigational
AprepitantThe serum concentration of Telithromycin can be increased when it is combined with Aprepitant.Approved, Investigational
ArformoterolArformoterol may increase the QTc-prolonging activities of Telithromycin.Approved, Investigational
ArgatrobanThe metabolism of Argatroban can be decreased when combined with Telithromycin.Approved, Investigational
AripiprazoleThe serum concentration of Aripiprazole can be increased when it is combined with Telithromycin.Approved, Investigational
Arsenic trioxideTelithromycin may increase the QTc-prolonging activities of Arsenic trioxide.Approved, Investigational
ArtemetherTelithromycin may increase the QTc-prolonging activities of Artemether.Approved
AsenapineTelithromycin may increase the QTc-prolonging activities of Asenapine.Approved
AstemizoleThe serum concentration of Astemizole can be increased when it is combined with Telithromycin.Approved, Withdrawn
AtazanavirThe metabolism of Atazanavir can be decreased when combined with Telithromycin.Approved, Investigational
AtomoxetineAtomoxetine may increase the QTc-prolonging activities of Telithromycin.Approved
AtorvastatinThe serum concentration of Atorvastatin can be increased when it is combined with Telithromycin.Approved
AvanafilThe serum concentration of Avanafil can be increased when it is combined with Telithromycin.Approved
AxitinibThe serum concentration of Axitinib can be increased when it is combined with Telithromycin.Approved, Investigational
AzelastineThe metabolism of Azelastine can be decreased when combined with Telithromycin.Approved
AzelnidipineThe metabolism of Azelnidipine can be decreased when combined with Telithromycin.Approved
AzimilideThe metabolism of Azimilide can be decreased when combined with Telithromycin.Investigational
AzithromycinAzithromycin may increase the QTc-prolonging activities of Telithromycin.Approved
BanoxantroneThe metabolism of Banoxantrone can be decreased when combined with Telithromycin.Investigational
BarnidipineThe serum concentration of Barnidipine can be increased when it is combined with Telithromycin.Approved
BcgThe therapeutic efficacy of Bcg can be decreased when used in combination with Telithromycin.Investigational
BeclomethasoneThe serum concentration of Beclomethasone can be increased when it is combined with Telithromycin.Investigational
Beclomethasone dipropionateThe serum concentration of Beclomethasone dipropionate can be increased when it is combined with Telithromycin.Approved, Investigational
BedaquilineThe serum concentration of Bedaquiline can be increased when it is combined with Telithromycin.Approved
BenidipineThe metabolism of Benidipine can be decreased when combined with Telithromycin.Approved
BenzphetamineThe metabolism of Benzphetamine can be decreased when combined with Telithromycin.Approved, Illicit
Benzyl alcoholThe metabolism of Benzyl alcohol can be decreased when combined with Telithromycin.Approved
BepridilThe metabolism of Bepridil can be decreased when combined with Telithromycin.Approved, Withdrawn
BetamethasoneThe serum concentration of Betamethasone can be increased when it is combined with Telithromycin.Approved, Vet Approved
BexaroteneThe metabolism of Bexarotene can be decreased when combined with Telithromycin.Approved, Investigational
BezafibrateThe metabolism of Bezafibrate can be decreased when combined with Telithromycin.Approved
BicalutamideThe metabolism of Bicalutamide can be decreased when combined with Telithromycin.Approved
BisoprololThe metabolism of Bisoprolol can be decreased when combined with Telithromycin.Approved
BoceprevirThe metabolism of Boceprevir can be decreased when combined with Telithromycin.Approved
BortezomibThe serum concentration of Bortezomib can be increased when it is combined with Telithromycin.Approved, Investigational
BosentanThe serum concentration of Telithromycin can be decreased when it is combined with Bosentan.Approved, Investigational
BosutinibThe serum concentration of Bosutinib can be increased when it is combined with Telithromycin.Approved
Brentuximab vedotinThe serum concentration of Brentuximab vedotin can be increased when it is combined with Telithromycin.Approved
BrexpiprazoleThe serum concentration of Brexpiprazole can be increased when it is combined with Telithromycin.Approved
BrinzolamideThe serum concentration of Brinzolamide can be increased when it is combined with Telithromycin.Approved
BromazepamThe metabolism of Bromazepam can be decreased when combined with Telithromycin.Approved, Illicit
BromocriptineThe metabolism of Bromocriptine can be decreased when combined with Telithromycin.Approved, Investigational
BrompheniramineThe metabolism of Brompheniramine can be decreased when combined with Telithromycin.Approved
BudesonideThe serum concentration of Budesonide can be increased when it is combined with Telithromycin.Approved
BudesonideThe metabolism of Budesonide can be decreased when combined with Telithromycin.Approved
BupivacaineThe metabolism of Bupivacaine can be decreased when combined with Telithromycin.Approved, Investigational
BuprenorphineThe metabolism of Buprenorphine can be decreased when combined with Telithromycin.Approved, Illicit, Investigational, Vet Approved
BupropionThe metabolism of Bupropion can be decreased when combined with Telithromycin.Approved
BuserelinBuserelin may increase the QTc-prolonging activities of Telithromycin.Approved
BuspironeThe metabolism of Buspirone can be decreased when combined with Telithromycin.Approved, Investigational
BusulfanThe metabolism of Busulfan can be decreased when combined with Telithromycin.Approved, Investigational
CabazitaxelThe serum concentration of Cabazitaxel can be increased when it is combined with Telithromycin.Approved
CabergolineThe metabolism of Cabergoline can be decreased when combined with Telithromycin.Approved
CabozantinibThe serum concentration of Cabozantinib can be increased when it is combined with Telithromycin.Approved
CaffeineThe metabolism of Caffeine can be decreased when combined with Telithromycin.Approved
CaiThe metabolism of Cai can be decreased when combined with Telithromycin.Investigational
CalcitriolThe metabolism of Calcitriol can be decreased when combined with Telithromycin.Approved, Nutraceutical
CanagliflozinThe metabolism of Canagliflozin can be decreased when combined with Telithromycin.Approved
CarbamazepineThe metabolism of Carbamazepine can be decreased when combined with Telithromycin.Approved, Investigational
CarbinoxamineThe metabolism of Carbinoxamine can be decreased when combined with Telithromycin.Approved
CariprazineThe metabolism of Cariprazine can be decreased when combined with Telithromycin.Approved
CarvedilolThe metabolism of Carvedilol can be decreased when combined with Telithromycin.Approved, Investigational
CelecoxibThe metabolism of Celecoxib can be decreased when combined with Telithromycin.Approved, Investigational
CeliprololThe metabolism of Celiprolol can be decreased when combined with Telithromycin.Approved, Investigational
CephalexinThe metabolism of Cephalexin can be decreased when combined with Telithromycin.Approved, Vet Approved
CeritinibThe serum concentration of Ceritinib can be increased when it is combined with Telithromycin.Approved
CerivastatinThe metabolism of Cerivastatin can be decreased when combined with Telithromycin.Withdrawn
CevimelineThe metabolism of Cevimeline can be decreased when combined with Telithromycin.Approved
Chenodeoxycholic acidThe metabolism of Chenodeoxycholic acid can be decreased when combined with Telithromycin.Approved
ChlordiazepoxideThe metabolism of Chlordiazepoxide can be decreased when combined with Telithromycin.Approved, Illicit
ChloroquineChloroquine may increase the QTc-prolonging activities of Telithromycin.Approved, Vet Approved
ChlorphenamineThe metabolism of Chlorphenamine can be decreased when combined with Telithromycin.Approved
ChlorpromazineChlorpromazine may increase the QTc-prolonging activities of Telithromycin.Approved, Vet Approved
ChlorzoxazoneThe metabolism of Chlorzoxazone can be decreased when combined with Telithromycin.Approved
CholecalciferolThe metabolism of Cholecalciferol can be decreased when combined with Telithromycin.Approved, Nutraceutical
CiclesonideThe metabolism of Ciclesonide can be decreased when combined with Telithromycin.Approved, Investigational
CilnidipineThe metabolism of Cilnidipine can be decreased when combined with Telithromycin.Approved
CilostazolThe serum concentration of Cilostazol can be increased when it is combined with Telithromycin.Approved
CinacalcetThe metabolism of Cinacalcet can be decreased when combined with Telithromycin.Approved
CinnarizineThe metabolism of Cinnarizine can be decreased when combined with Telithromycin.Approved
CiprofloxacinCiprofloxacin may increase the QTc-prolonging activities of Telithromycin.Approved, Investigational
CisaprideThe metabolism of Cisapride can be decreased when combined with Telithromycin.Approved, Investigational, Withdrawn
CitalopramTelithromycin may increase the QTc-prolonging activities of Citalopram.Approved
ClarithromycinTelithromycin may increase the QTc-prolonging activities of Clarithromycin.Approved
ClemastineThe metabolism of Telithromycin can be decreased when combined with Clemastine.Approved
ClindamycinThe metabolism of Clindamycin can be decreased when combined with Telithromycin.Approved, Vet Approved
ClobazamThe metabolism of Clobazam can be decreased when combined with Telithromycin.Approved, Illicit
ClobetasolThe serum concentration of Clobetasol can be increased when it is combined with Telithromycin.Investigational
Clobetasol propionateThe serum concentration of Clobetasol propionate can be increased when it is combined with Telithromycin.Approved
ClocortoloneThe serum concentration of Clocortolone can be increased when it is combined with Telithromycin.Approved
ClofazimineThe metabolism of Clofazimine can be decreased when combined with Telithromycin.Approved, Investigational
ClofibrateThe metabolism of Clofibrate can be decreased when combined with Telithromycin.Approved
clomethiazoleThe metabolism of clomethiazole can be decreased when combined with Telithromycin.Investigational
ClomipramineThe metabolism of Clomipramine can be decreased when combined with Telithromycin.Approved, Vet Approved
ClonazepamThe metabolism of Clonazepam can be decreased when combined with Telithromycin.Approved, Illicit
ClonidineThe metabolism of Clonidine can be decreased when combined with Telithromycin.Approved
ClopidogrelThe metabolism of Clopidogrel can be decreased when combined with Telithromycin.Approved, Nutraceutical
ClorazepateThe metabolism of Clorazepate can be decreased when combined with Telithromycin.Approved, Illicit
ClotiazepamThe metabolism of Clotiazepam can be decreased when combined with Telithromycin.Approved, Illicit
ClotrimazoleThe metabolism of Telithromycin can be decreased when combined with Clotrimazole.Approved, Vet Approved
ClozapineClozapine may increase the QTc-prolonging activities of Telithromycin.Approved
CobicistatThe serum concentration of Cobicistat can be increased when it is combined with Telithromycin.Approved
CobimetinibThe serum concentration of Cobimetinib can be increased when it is combined with Telithromycin.Approved
CocaineThe metabolism of Cocaine can be decreased when combined with Telithromycin.Approved, Illicit
CodeineThe metabolism of Codeine can be decreased when combined with Telithromycin.Approved, Illicit
ColchicineThe serum concentration of Colchicine can be increased when it is combined with Telithromycin.Approved
ConivaptanThe serum concentration of Conivaptan can be increased when it is combined with Telithromycin.Approved, Investigational
Conjugated Equine EstrogensThe metabolism of Conjugated Equine Estrogens can be decreased when combined with Telithromycin.Approved
Cortisone acetateThe metabolism of Cortisone acetate can be decreased when combined with Telithromycin.Approved
CrizotinibThe serum concentration of Crizotinib can be increased when it is combined with Telithromycin.Approved
CyclobenzaprineThe metabolism of Cyclobenzaprine can be decreased when combined with Telithromycin.Approved
CyclophosphamideThe metabolism of Cyclophosphamide can be decreased when combined with Telithromycin.Approved, Investigational
CyclosporineThe metabolism of Cyclosporine can be decreased when combined with Telithromycin.Approved, Investigational, Vet Approved
Cyproterone acetateThe serum concentration of Telithromycin can be decreased when it is combined with Cyproterone acetate.Approved, Investigational
CytarabineThe metabolism of Cytarabine can be decreased when combined with Telithromycin.Approved, Investigational
DabrafenibThe serum concentration of Telithromycin can be decreased when it is combined with Dabrafenib.Approved
DaclatasvirThe serum concentration of Daclatasvir can be increased when it is combined with Telithromycin.Approved
DantroleneThe metabolism of Dantrolene can be decreased when combined with Telithromycin.Approved
DapagliflozinThe metabolism of Dapagliflozin can be decreased when combined with Telithromycin.Approved
DapoxetineThe serum concentration of Dapoxetine can be increased when it is combined with Telithromycin.Investigational
DapsoneThe metabolism of Dapsone can be decreased when combined with Telithromycin.Approved, Investigational
DarifenacinThe metabolism of Darifenacin can be decreased when combined with Telithromycin.Approved, Investigational
DarodipineThe metabolism of Darodipine can be decreased when combined with Telithromycin.Experimental
DarunavirThe metabolism of Darunavir can be decreased when combined with Telithromycin.Approved
DasabuvirThe metabolism of Dasabuvir can be decreased when combined with Telithromycin.Approved
DasatinibThe serum concentration of Dasatinib can be increased when it is combined with Telithromycin.Approved, Investigational
DaunorubicinThe metabolism of Daunorubicin can be decreased when combined with Telithromycin.Approved
DeferasiroxThe serum concentration of Telithromycin can be decreased when it is combined with Deferasirox.Approved, Investigational
DegarelixDegarelix may increase the QTc-prolonging activities of Telithromycin.Approved
dehydroepiandrosterone sulfateThe serum concentration of dehydroepiandrosterone sulfate can be increased when it is combined with Telithromycin.Investigational
DelavirdineThe metabolism of Delavirdine can be decreased when combined with Telithromycin.Approved
DesfluraneDesflurane may increase the QTc-prolonging activities of Telithromycin.Approved
DesipramineDesipramine may increase the QTc-prolonging activities of Telithromycin.Approved
DeslanosideThe serum concentration of Deslanoside can be increased when it is combined with Telithromycin.Approved
DesoximetasoneThe serum concentration of Desoximetasone can be increased when it is combined with Telithromycin.Approved
Desoxycorticosterone acetateThe serum concentration of Desoxycorticosterone acetate can be increased when it is combined with Telithromycin.Approved
Desoxycorticosterone PivalateThe serum concentration of Desoxycorticosterone Pivalate can be increased when it is combined with Telithromycin.Experimental, Vet Approved
DesvenlafaxineThe metabolism of Desvenlafaxine can be decreased when combined with Telithromycin.Approved
DexamethasoneThe metabolism of Dexamethasone can be decreased when combined with Telithromycin.Approved, Investigational, Vet Approved
Dexamethasone isonicotinateThe serum concentration of Dexamethasone isonicotinate can be increased when it is combined with Telithromycin.Vet Approved
DextromethorphanThe metabolism of Dextromethorphan can be decreased when combined with Telithromycin.Approved
DextropropoxypheneThe metabolism of Dextropropoxyphene can be decreased when combined with Telithromycin.Approved, Illicit, Withdrawn
DiazepamThe metabolism of Diazepam can be decreased when combined with Telithromycin.Approved, Illicit, Vet Approved
DiclofenacThe metabolism of Diclofenac can be decreased when combined with Telithromycin.Approved, Vet Approved
DicoumarolThe serum concentration of Dicoumarol can be increased when it is combined with Telithromycin.Approved
DienogestThe serum concentration of Dienogest can be increased when it is combined with Telithromycin.Approved
DiflorasoneThe serum concentration of Diflorasone can be increased when it is combined with Telithromycin.Approved
DifluocortoloneThe serum concentration of Difluocortolone can be increased when it is combined with Telithromycin.Approved
DifluprednateThe serum concentration of Difluprednate can be increased when it is combined with Telithromycin.Approved
DigitoxinThe metabolism of Digitoxin can be decreased when combined with Telithromycin.Approved
DigoxinThe metabolism of Digoxin can be decreased when combined with Telithromycin.Approved
DihydrocodeineThe metabolism of Dihydrocodeine can be decreased when combined with Telithromycin.Approved, Illicit
DihydroergotamineThe metabolism of Dihydroergotamine can be decreased when combined with Telithromycin.Approved
DiltiazemThe metabolism of Diltiazem can be decreased when combined with Telithromycin.Approved
DiphenhydramineDiphenhydramine may increase the QTc-prolonging activities of Telithromycin.Approved
DisopyramideTelithromycin may increase the QTc-prolonging activities of Disopyramide.Approved
DisulfiramThe metabolism of Disulfiram can be decreased when combined with Telithromycin.Approved
DocetaxelThe metabolism of Docetaxel can be decreased when combined with Telithromycin.Approved, Investigational
DofetilideThe serum concentration of Dofetilide can be increased when it is combined with Telithromycin.Approved
DolasetronDolasetron may increase the QTc-prolonging activities of Telithromycin.Approved
DomperidoneThe serum concentration of Domperidone can be increased when it is combined with Telithromycin.Approved, Investigational, Vet Approved
DonepezilThe metabolism of Donepezil can be decreased when combined with Telithromycin.Approved
DorzolamideThe metabolism of Dorzolamide can be decreased when combined with Telithromycin.Approved
DotarizineThe metabolism of Dotarizine can be decreased when combined with Telithromycin.Investigational
DoxepinThe metabolism of Doxepin can be decreased when combined with Telithromycin.Approved
DoxorubicinThe serum concentration of Doxorubicin can be increased when it is combined with Telithromycin.Approved, Investigational
DoxorubicinThe metabolism of Doxorubicin can be decreased when combined with Telithromycin.Approved, Investigational
DoxycyclineThe metabolism of Telithromycin can be decreased when combined with Doxycycline.Approved, Investigational, Vet Approved
DronabinolThe serum concentration of Dronabinol can be increased when it is combined with Telithromycin.Approved, Illicit
DronedaroneThe serum concentration of Dronedarone can be increased when it is combined with Telithromycin.Approved
DroperidolDroperidol may increase the QTc-prolonging activities of Telithromycin.Approved, Vet Approved
DrospirenoneThe serum concentration of Drospirenone can be increased when it is combined with Telithromycin.Approved
DutasterideThe serum concentration of Dutasteride can be increased when it is combined with Telithromycin.Approved, Investigational
EfavirenzThe metabolism of Efavirenz can be decreased when combined with Telithromycin.Approved, Investigational
EfonidipineThe metabolism of Efonidipine can be decreased when combined with Telithromycin.Approved
EletriptanThe serum concentration of Eletriptan can be increased when it is combined with Telithromycin.Approved, Investigational
EliglustatThe serum concentration of Eliglustat can be increased when it is combined with Telithromycin.Approved
ElvitegravirThe metabolism of Elvitegravir can be decreased when combined with Telithromycin.Approved
EnalaprilThe metabolism of Enalapril can be decreased when combined with Telithromycin.Approved, Vet Approved
EnzalutamideThe serum concentration of Telithromycin can be decreased when it is combined with Enzalutamide.Approved
EperisoneThe metabolism of Eperisone can be decreased when combined with Telithromycin.Approved, Investigational
EpinastineThe metabolism of Epinastine can be decreased when combined with Telithromycin.Approved, Investigational
EplerenoneThe serum concentration of Eplerenone can be increased when it is combined with Telithromycin.Approved
EquileninThe serum concentration of Equilenin can be increased when it is combined with Telithromycin.Experimental
EquilinThe serum concentration of Equilin can be increased when it is combined with Telithromycin.Approved
ErgocalciferolThe metabolism of Ergocalciferol can be decreased when combined with Telithromycin.Approved, Nutraceutical
Ergoloid mesylateThe metabolism of Ergoloid mesylate can be decreased when combined with Telithromycin.Approved
ErgonovineThe metabolism of Ergonovine can be decreased when combined with Telithromycin.Approved
ErgotamineThe metabolism of Ergotamine can be decreased when combined with Telithromycin.Approved
EribulinEribulin may increase the QTc-prolonging activities of Telithromycin.Approved, Investigational
ErlotinibThe serum concentration of Erlotinib can be increased when it is combined with Telithromycin.Approved, Investigational
ErythromycinErythromycin may increase the QTc-prolonging activities of Telithromycin.Approved, Vet Approved
EscitalopramTelithromycin may increase the QTc-prolonging activities of Escitalopram.Approved, Investigational
Eslicarbazepine acetateThe serum concentration of Telithromycin can be decreased when it is combined with Eslicarbazepine acetate.Approved
EsomeprazoleThe metabolism of Esomeprazole can be decreased when combined with Telithromycin.Approved, Investigational
EstazolamThe serum concentration of Estazolam can be increased when it is combined with Telithromycin.Approved, Illicit
EstradiolThe metabolism of Estradiol can be decreased when combined with Telithromycin.Approved, Investigational, Vet Approved
Estradiol valerate/DienogestThe metabolism of Estradiol valerate/Dienogest can be decreased when combined with Telithromycin.Approved
EstramustineThe metabolism of Estramustine can be decreased when combined with Telithromycin.Approved
EstroneThe metabolism of Estrone can be decreased when combined with Telithromycin.Approved
Estrone sulfateThe metabolism of Estrone sulfate can be decreased when combined with Telithromycin.Approved
EszopicloneThe metabolism of Eszopiclone can be decreased when combined with Telithromycin.Approved
EthanolThe metabolism of Ethanol can be decreased when combined with Telithromycin.Approved
Ethinyl EstradiolThe metabolism of Ethinyl Estradiol can be decreased when combined with Telithromycin.Approved
EthosuximideThe metabolism of Ethosuximide can be decreased when combined with Telithromycin.Approved
Ethyl biscoumacetateThe serum concentration of Ethyl biscoumacetate can be increased when it is combined with Telithromycin.Withdrawn
EthylmorphineThe metabolism of Ethylmorphine can be decreased when combined with Telithromycin.Approved, Illicit
EtizolamThe serum concentration of Etizolam can be increased when it is combined with Telithromycin.Approved
EtonogestrelThe metabolism of Etonogestrel can be decreased when combined with Telithromycin.Approved, Investigational
EtoposideThe metabolism of Etoposide can be decreased when combined with Telithromycin.Approved
EtoricoxibThe metabolism of Etoricoxib can be decreased when combined with Telithromycin.Approved, Investigational
EtravirineThe metabolism of Etravirine can be decreased when combined with Telithromycin.Approved
EverolimusThe serum concentration of Everolimus can be increased when it is combined with Telithromycin.Approved
ExemestaneThe metabolism of Exemestane can be decreased when combined with Telithromycin.Approved, Investigational
EzogabineEzogabine may increase the QTc-prolonging activities of Telithromycin.Approved
FamciclovirThe metabolism of Famciclovir can be decreased when combined with Telithromycin.Approved
FamotidineFamotidine may increase the QTc-prolonging activities of Telithromycin.Approved
FelbamateThe metabolism of Felbamate can be decreased when combined with Telithromycin.Approved
FelodipineThe metabolism of Felodipine can be decreased when combined with Telithromycin.Approved, Investigational
FendilineThe metabolism of Fendiline can be decreased when combined with Telithromycin.Withdrawn
FenofibrateThe metabolism of Fenofibrate can be decreased when combined with Telithromycin.Approved
FentanylThe serum concentration of Fentanyl can be increased when it is combined with Telithromycin.Approved, Illicit, Investigational, Vet Approved
FesoterodineThe serum concentration of the active metabolites of Fesoterodine can be increased when Fesoterodine is used in combination with Telithromycin.Approved
FinasterideThe metabolism of Finasteride can be decreased when combined with Telithromycin.Approved
FingolimodThe metabolism of Fingolimod can be decreased when combined with Telithromycin.Approved, Investigational
FlecainideTelithromycin may increase the QTc-prolonging activities of Flecainide.Approved, Withdrawn
FlibanserinThe serum concentration of Flibanserin can be increased when it is combined with Telithromycin.Approved
fluasteroneThe serum concentration of fluasterone can be increased when it is combined with Telithromycin.Investigational
FluconazoleFluconazole may increase the QTc-prolonging activities of Telithromycin.Approved
FludrocortisoneThe serum concentration of Fludrocortisone can be increased when it is combined with Telithromycin.Approved
FluindioneThe serum concentration of Fluindione can be increased when it is combined with Telithromycin.Investigational
FlumethasoneThe serum concentration of Flumethasone can be increased when it is combined with Telithromycin.Approved, Vet Approved
FlunarizineThe metabolism of Flunarizine can be decreased when combined with Telithromycin.Approved
FlunisolideThe metabolism of Flunisolide can be decreased when combined with Telithromycin.Approved, Investigational
FlunitrazepamThe metabolism of Flunitrazepam can be decreased when combined with Telithromycin.Approved, Illicit
Fluocinolone AcetonideThe serum concentration of Fluocinolone Acetonide can be increased when it is combined with Telithromycin.Approved, Investigational, Vet Approved
FluocinonideThe serum concentration of Fluocinonide can be increased when it is combined with Telithromycin.Approved, Investigational
FluocortoloneThe serum concentration of Fluocortolone can be increased when it is combined with Telithromycin.Approved, Withdrawn
FluorometholoneThe metabolism of Fluorometholone can be decreased when combined with Telithromycin.Approved
FluoxetineTelithromycin may increase the QTc-prolonging activities of Fluoxetine.Approved, Vet Approved
FlupentixolTelithromycin may increase the QTc-prolonging activities of Flupentixol.Approved, Withdrawn
FluprednideneThe serum concentration of Fluprednidene can be increased when it is combined with Telithromycin.Approved, Withdrawn
FluprednisoloneThe serum concentration of Fluprednisolone can be increased when it is combined with Telithromycin.Approved
FlurandrenolideThe serum concentration of Flurandrenolide can be increased when it is combined with Telithromycin.Approved
FlurazepamThe metabolism of Flurazepam can be decreased when combined with Telithromycin.Approved, Illicit
FlutamideThe metabolism of Flutamide can be decreased when combined with Telithromycin.Approved
Fluticasone furoateThe metabolism of Fluticasone furoate can be decreased when combined with Telithromycin.Approved
Fluticasone PropionateThe serum concentration of Fluticasone Propionate can be increased when it is combined with Telithromycin.Approved
Fluticasone PropionateThe metabolism of Fluticasone Propionate can be decreased when combined with Telithromycin.Approved
FluvastatinThe metabolism of Fluvastatin can be decreased when combined with Telithromycin.Approved
FluvoxamineThe metabolism of Telithromycin can be decreased when combined with Fluvoxamine.Approved, Investigational
FormestaneThe serum concentration of Formestane can be increased when it is combined with Telithromycin.Approved, Investigational, Withdrawn
FormoterolFormoterol may increase the QTc-prolonging activities of Telithromycin.Approved, Investigational
FosamprenavirThe metabolism of Fosamprenavir can be decreased when combined with Telithromycin.Approved
FosaprepitantThe serum concentration of Telithromycin can be increased when it is combined with Fosaprepitant.Approved
FoscarnetFoscarnet may increase the QTc-prolonging activities of Telithromycin.Approved
FosphenytoinThe metabolism of Telithromycin can be increased when combined with Fosphenytoin.Approved
FulvestrantThe metabolism of Fulvestrant can be decreased when combined with Telithromycin.Approved, Investigational
Fusidic AcidThe serum concentration of Telithromycin can be increased when it is combined with Fusidic Acid.Approved
GabapentinThe metabolism of Gabapentin can be decreased when combined with Telithromycin.Approved, Investigational
Gadobenic acidGadobenic acid may increase the QTc-prolonging activities of Telithromycin.Approved
GalantamineThe metabolism of Galantamine can be decreased when combined with Telithromycin.Approved
GallopamilThe metabolism of Gallopamil can be decreased when combined with Telithromycin.Investigational
GefitinibThe metabolism of Gefitinib can be decreased when combined with Telithromycin.Approved, Investigational
GemfibrozilThe metabolism of Gemfibrozil can be decreased when combined with Telithromycin.Approved
GemifloxacinTelithromycin may increase the QTc-prolonging activities of Gemifloxacin.Approved, Investigational
GlipizideThe metabolism of Glipizide can be decreased when combined with Telithromycin.Approved
GlyburideThe metabolism of Glyburide can be decreased when combined with Telithromycin.Approved
GoserelinGoserelin may increase the QTc-prolonging activities of Telithromycin.Approved
GranisetronGranisetron may increase the QTc-prolonging activities of Telithromycin.Approved, Investigational
GrepafloxacinThe metabolism of Grepafloxacin can be decreased when combined with Telithromycin.Withdrawn
GuanfacineThe serum concentration of Guanfacine can be increased when it is combined with Telithromycin.Approved, Investigational
HalofantrineThe serum concentration of Halofantrine can be increased when it is combined with Telithromycin.Approved
HaloperidolHaloperidol may increase the QTc-prolonging activities of Telithromycin.Approved
HalothaneThe metabolism of Halothane can be decreased when combined with Telithromycin.Approved, Vet Approved
HE3286The serum concentration of HE3286 can be increased when it is combined with Telithromycin.Investigational
HexobarbitalThe metabolism of Hexobarbital can be decreased when combined with Telithromycin.Approved
Histamine PhosphateThe metabolism of Histamine Phosphate can be decreased when combined with Telithromycin.Approved
HistrelinHistrelin may increase the QTc-prolonging activities of Telithromycin.Approved
HydrocodoneThe serum concentration of Hydrocodone can be increased when it is combined with Telithromycin.Approved, Illicit
HydrocortisoneThe metabolism of Hydrocortisone can be decreased when combined with Telithromycin.Approved, Vet Approved
HydromorphoneThe metabolism of Hydromorphone can be decreased when combined with Telithromycin.Approved, Illicit
Hydroxyprogesterone caproateThe metabolism of Hydroxyprogesterone caproate can be decreased when combined with Telithromycin.Approved
HydroxyzineHydroxyzine may increase the QTc-prolonging activities of Telithromycin.Approved
IbandronateIbandronate may increase the QTc-prolonging activities of Telithromycin.Approved, Investigational
IbrutinibThe serum concentration of Ibrutinib can be increased when it is combined with Telithromycin.Approved
IbutilideTelithromycin may increase the QTc-prolonging activities of Ibutilide.Approved
IdelalisibThe serum concentration of Telithromycin can be increased when it is combined with Idelalisib.Approved
IfosfamideThe serum concentration of the active metabolites of Ifosfamide can be reduced when Ifosfamide is used in combination with Telithromycin resulting in a loss in efficacy.Approved
IloperidoneThe serum concentration of the active metabolites of Iloperidone can be increased when Iloperidone is used in combination with Telithromycin.Approved
ImatinibThe serum concentration of Imatinib can be increased when it is combined with Telithromycin.Approved
ImidafenacinThe serum concentration of Imidafenacin can be increased when it is combined with Telithromycin.Approved
ImipramineThe metabolism of Imipramine can be decreased when combined with Telithromycin.Approved
ImiquimodThe metabolism of Imiquimod can be decreased when combined with Telithromycin.Approved, Investigational
IndacaterolThe metabolism of Indacaterol can be decreased when combined with Telithromycin.Approved
IndapamideThe metabolism of Indapamide can be decreased when combined with Telithromycin.Approved
IndinavirThe metabolism of Telithromycin can be decreased when combined with Indinavir.Approved
Ipratropium bromideThe metabolism of Ipratropium bromide can be decreased when combined with Telithromycin.Approved
IrinotecanThe serum concentration of the active metabolites of Irinotecan can be increased when Irinotecan is used in combination with Telithromycin.Approved, Investigational
IsavuconazoniumThe serum concentration of the active metabolites of Isavuconazonium can be increased when Isavuconazonium is used in combination with Telithromycin.Approved, Investigational
IsofluraneIsoflurane may increase the QTc-prolonging activities of Telithromycin.Approved, Vet Approved
Isosorbide DinitrateThe metabolism of Isosorbide Dinitrate can be decreased when combined with Telithromycin.Approved
Isosorbide MononitrateThe metabolism of Isosorbide Mononitrate can be decreased when combined with Telithromycin.Approved
IsradipineThe metabolism of Isradipine can be decreased when combined with Telithromycin.Approved
IstaroximeThe serum concentration of Istaroxime can be increased when it is combined with Telithromycin.Investigational
ItraconazoleThe serum concentration of Telithromycin can be increased when it is combined with Itraconazole.Approved, Investigational
IvabradineThe serum concentration of Ivabradine can be increased when it is combined with Telithromycin.Approved
IvacaftorThe serum concentration of Ivacaftor can be increased when it is combined with Telithromycin.Approved
IvermectinThe metabolism of Ivermectin can be decreased when combined with Telithromycin.Approved, Vet Approved
IxabepiloneThe serum concentration of Ixabepilone can be increased when it is combined with Telithromycin.Approved, Investigational
IxazomibThe metabolism of Ixazomib can be decreased when combined with Telithromycin.Approved
KetamineThe metabolism of Ketamine can be decreased when combined with Telithromycin.Approved, Vet Approved
KetazolamThe metabolism of Ketazolam can be decreased when combined with Telithromycin.Approved
KetobemidoneThe metabolism of Ketobemidone can be decreased when combined with Telithromycin.Approved
KetoconazoleThe serum concentration of Telithromycin can be increased when it is combined with Ketoconazole.Approved, Investigational
KetoconazoleThe metabolism of Ketoconazole can be decreased when combined with Telithromycin.Approved, Investigational
LacidipineThe metabolism of Lacidipine can be decreased when combined with Telithromycin.Approved
LacosamideThe serum concentration of Lacosamide can be increased when it is combined with Telithromycin.Approved
LamotrigineThe metabolism of Lamotrigine can be decreased when combined with Telithromycin.Approved, Investigational
LansoprazoleThe metabolism of Lansoprazole can be decreased when combined with Telithromycin.Approved, Investigational
LapatinibThe serum concentration of Lapatinib can be increased when it is combined with Telithromycin.Approved, Investigational
LaquinimodThe metabolism of Laquinimod can be decreased when combined with Telithromycin.Investigational
LenvatinibTelithromycin may increase the QTc-prolonging activities of Lenvatinib.Approved
LercanidipineThe serum concentration of Lercanidipine can be increased when it is combined with Telithromycin.Approved, Investigational
LetrozoleThe metabolism of Letrozole can be decreased when combined with Telithromycin.Approved, Investigational
LeuprolideLeuprolide may increase the QTc-prolonging activities of Telithromycin.Approved, Investigational
LevobupivacaineThe serum concentration of Levobupivacaine can be increased when it is combined with Telithromycin.Approved
LevocetirizineThe metabolism of Levocetirizine can be decreased when combined with Telithromycin.Approved
LevofloxacinTelithromycin may increase the QTc-prolonging activities of Levofloxacin.Approved, Investigational
Levomethadyl AcetateThe metabolism of Levomethadyl Acetate can be decreased when combined with Telithromycin.Approved
LevomilnacipranThe serum concentration of Levomilnacipran can be increased when it is combined with Telithromycin.Approved
LevonorgestrelThe metabolism of Levonorgestrel can be decreased when combined with Telithromycin.Approved, Investigational
LevothyroxineThe metabolism of Levothyroxine can be decreased when combined with Telithromycin.Approved
LidocaineThe metabolism of Lidocaine can be decreased when combined with Telithromycin.Approved, Vet Approved
LisurideThe metabolism of Lisuride can be decreased when combined with Telithromycin.Approved
LithiumLithium may increase the QTc-prolonging activities of Telithromycin.Approved
LomitapideThe serum concentration of Lomitapide can be increased when it is combined with Telithromycin.Approved
LoperamideThe metabolism of Loperamide can be decreased when combined with Telithromycin.Approved
LopinavirTelithromycin may increase the QTc-prolonging activities of Lopinavir.Approved
LoratadineThe metabolism of Loratadine can be decreased when combined with Telithromycin.Approved
LorcaserinThe metabolism of Lorcaserin can be decreased when combined with Telithromycin.Approved
LosartanThe metabolism of Losartan can be decreased when combined with Telithromycin.Approved
LovastatinThe serum concentration of Lovastatin can be increased when it is combined with Telithromycin.Approved, Investigational
LuliconazoleThe serum concentration of Telithromycin can be increased when it is combined with Luliconazole.Approved
LumacaftorThe metabolism of Telithromycin can be increased when combined with Lumacaftor.Approved
LumefantrineThe serum concentration of Lumefantrine can be increased when it is combined with Telithromycin.Approved
LurasidoneThe serum concentration of Lurasidone can be increased when it is combined with Telithromycin.Approved
MacitentanThe serum concentration of Macitentan can be increased when it is combined with Telithromycin.Approved
Magnesium SulfateThe metabolism of Magnesium Sulfate can be decreased when combined with Telithromycin.Approved, Vet Approved
ManidipineThe metabolism of Manidipine can be decreased when combined with Telithromycin.Approved
MaprotilineMaprotiline may increase the QTc-prolonging activities of Telithromycin.Approved
MaravirocThe serum concentration of Maraviroc can be increased when it is combined with Telithromycin.Approved, Investigational
ME-609The serum concentration of ME-609 can be increased when it is combined with Telithromycin.Investigational
MebendazoleThe metabolism of Mebendazole can be decreased when combined with Telithromycin.Approved, Vet Approved
Medroxyprogesterone acetateThe serum concentration of Medroxyprogesterone acetate can be increased when it is combined with Telithromycin.Approved, Investigational
MedrysoneThe serum concentration of Medrysone can be increased when it is combined with Telithromycin.Approved
MefloquineThe metabolism of Mefloquine can be decreased when combined with Telithromycin.Approved
MelengestrolThe serum concentration of Melengestrol can be increased when it is combined with Telithromycin.Vet Approved
MeloxicamThe metabolism of Meloxicam can be decreased when combined with Telithromycin.Approved, Vet Approved
MethadoneMethadone may increase the QTc-prolonging activities of Telithromycin.Approved
MethaqualoneThe metabolism of Methaqualone can be decreased when combined with Telithromycin.Illicit, Withdrawn
MethotrimeprazineMethotrimeprazine may increase the QTc-prolonging activities of Telithromycin.Approved
MethoxsalenThe metabolism of Methoxsalen can be decreased when combined with Telithromycin.Approved
MethoxyfluraneThe metabolism of Methoxyflurane can be decreased when combined with Telithromycin.Approved, Vet Approved
MethylprednisoloneThe serum concentration of Methylprednisolone can be increased when it is combined with Telithromycin.Approved, Vet Approved
MethyltestosteroneThe metabolism of Methyltestosterone can be decreased when combined with Telithromycin.Approved
MetoclopramideMetoclopramide may increase the QTc-prolonging activities of Telithromycin.Approved, Investigational
MetoprololThe serum concentration of Metoprolol can be increased when it is combined with Telithromycin.Approved, Investigational
MetronidazoleThe metabolism of Metronidazole can be decreased when combined with Telithromycin.Approved
MexiletineThe metabolism of Mexiletine can be decreased when combined with Telithromycin.Approved
MianserinThe metabolism of Mianserin can be decreased when combined with Telithromycin.Approved
MibefradilThe metabolism of Mibefradil can be decreased when combined with Telithromycin.Withdrawn
MiconazoleThe metabolism of Miconazole can be decreased when combined with Telithromycin.Approved, Investigational, Vet Approved
MidazolamThe serum concentration of Midazolam can be increased when it is combined with Telithromycin.Approved, Illicit
MifepristoneMifepristone may increase the QTc-prolonging activities of Telithromycin.Approved, Investigational
MirabegronThe metabolism of Mirabegron can be decreased when combined with Telithromycin.Approved
MirtazapineThe metabolism of Mirtazapine can be decreased when combined with Telithromycin.Approved
MitotaneThe serum concentration of Telithromycin can be decreased when it is combined with Mitotane.Approved
ModafinilThe metabolism of Modafinil can be decreased when combined with Telithromycin.Approved, Investigational
MoexiprilMoexipril may increase the QTc-prolonging activities of Telithromycin.Approved
MometasoneThe serum concentration of Mometasone can be increased when it is combined with Telithromycin.Approved, Vet Approved
MontelukastThe metabolism of Montelukast can be decreased when combined with Telithromycin.Approved
MorphineThe metabolism of Morphine can be decreased when combined with Telithromycin.Approved, Investigational
MoxifloxacinMoxifloxacin may increase the QTc-prolonging activities of Telithromycin.Approved, Investigational
Mycophenolate mofetilThe metabolism of Mycophenolate mofetil can be decreased when combined with Telithromycin.Approved, Investigational
NafcillinThe serum concentration of Telithromycin can be decreased when it is combined with Nafcillin.Approved
NaftopidilThe metabolism of Naftopidil can be decreased when combined with Telithromycin.Investigational
NaloxegolThe serum concentration of Naloxegol can be increased when it is combined with Telithromycin.Approved
NaloxoneThe metabolism of Naloxone can be decreased when combined with Telithromycin.Approved, Vet Approved
NateglinideThe metabolism of Nateglinide can be decreased when combined with Telithromycin.Approved, Investigational
NCX 1022The serum concentration of NCX 1022 can be increased when it is combined with Telithromycin.Investigational
NefazodoneThe metabolism of Nefazodone can be decreased when combined with Telithromycin.Approved, Withdrawn
NelfinavirThe metabolism of Telithromycin can be decreased when combined with Nelfinavir.Approved
NetupitantThe serum concentration of Telithromycin can be increased when it is combined with Netupitant.Approved
NevirapineThe metabolism of Telithromycin can be increased when combined with Nevirapine.Approved
NicardipineThe metabolism of Nicardipine can be decreased when combined with Telithromycin.Approved
NicotineThe metabolism of Nicotine can be decreased when combined with Telithromycin.Approved
NifedipineThe metabolism of Nifedipine can be decreased when combined with Telithromycin.Approved
NiguldipineThe metabolism of Niguldipine can be decreased when combined with Telithromycin.Experimental
NilotinibThe serum concentration of Nilotinib can be increased when it is combined with Telithromycin.Approved, Investigational
NiludipineThe metabolism of Niludipine can be decreased when combined with Telithromycin.Experimental
NilvadipineThe metabolism of Nilvadipine can be decreased when combined with Telithromycin.Approved
NimesulideThe metabolism of Nimesulide can be decreased when combined with Telithromycin.Approved, Withdrawn
NimodipineThe serum concentration of Nimodipine can be increased when it is combined with Telithromycin.Approved
NisoldipineThe serum concentration of Nisoldipine can be increased when it is combined with Telithromycin.Approved
NitrazepamThe metabolism of Nitrazepam can be decreased when combined with Telithromycin.Approved
NitrendipineThe metabolism of Nitrendipine can be decreased when combined with Telithromycin.Approved
NorethisteroneThe metabolism of Norethisterone can be decreased when combined with Telithromycin.Approved
NorfloxacinNorfloxacin may increase the QTc-prolonging activities of Telithromycin.Approved
NorgestrelThe metabolism of Norgestrel can be decreased when combined with Telithromycin.Approved
NortriptylineThe metabolism of Nortriptyline can be decreased when combined with Telithromycin.Approved
OctreotideOctreotide may increase the QTc-prolonging activities of Telithromycin.Approved, Investigational
OfloxacinTelithromycin may increase the QTc-prolonging activities of Ofloxacin.Approved
OlanzapineOlanzapine may increase the QTc-prolonging activities of Telithromycin.Approved, Investigational
OlaparibThe serum concentration of Olaparib can be increased when it is combined with Telithromycin.Approved
Oleoyl estroneThe serum concentration of Oleoyl estrone can be increased when it is combined with Telithromycin.Investigational
OlodaterolOlodaterol may increase the QTc-prolonging activities of Telithromycin.Approved
OlopatadineThe metabolism of Olopatadine can be decreased when combined with Telithromycin.Approved
OmeprazoleThe metabolism of Omeprazole can be decreased when combined with Telithromycin.Approved, Investigational, Vet Approved
OndansetronOndansetron may increase the QTc-prolonging activities of Telithromycin.Approved
OrphenadrineThe metabolism of Orphenadrine can be decreased when combined with Telithromycin.Approved
OsimertinibThe serum concentration of Osimertinib can be increased when it is combined with Telithromycin.Approved
OspemifeneThe serum concentration of Ospemifene can be increased when it is combined with Telithromycin.Approved
OuabainThe serum concentration of Ouabain can be increased when it is combined with Telithromycin.Approved
OxazepamThe metabolism of Oxazepam can be decreased when combined with Telithromycin.Approved
OxybutyninThe serum concentration of Oxybutynin can be increased when it is combined with Telithromycin.Approved, Investigational
OxycodoneThe risk or severity of adverse effects can be increased when Telithromycin is combined with Oxycodone.Approved, Illicit, Investigational
OxymorphoneThe metabolism of Oxymorphone can be decreased when combined with Telithromycin.Approved, Investigational, Vet Approved
OxytocinOxytocin may increase the QTc-prolonging activities of Telithromycin.Approved, Vet Approved
PaclitaxelThe metabolism of Paclitaxel can be decreased when combined with Telithromycin.Approved, Vet Approved
PalbociclibThe serum concentration of Palbociclib can be increased when it is combined with Telithromycin.Approved
PaliperidoneTelithromycin may increase the QTc-prolonging activities of Paliperidone.Approved
PalonosetronThe metabolism of Palonosetron can be decreased when combined with Telithromycin.Approved, Investigational
PanobinostatThe serum concentration of Panobinostat can be increased when it is combined with Telithromycin.Approved, Investigational
PantoprazoleThe metabolism of Pantoprazole can be decreased when combined with Telithromycin.Approved
ParamethadioneThe metabolism of Paramethadione can be decreased when combined with Telithromycin.Approved
ParamethasoneThe metabolism of Paramethasone can be decreased when combined with Telithromycin.Approved
ParecoxibThe serum concentration of Parecoxib can be increased when it is combined with Telithromycin.Approved
ParicalcitolThe serum concentration of Paricalcitol can be increased when it is combined with Telithromycin.Approved, Investigational
ParitaprevirThe metabolism of Paritaprevir can be decreased when combined with Telithromycin.Approved
ParoxetineParoxetine may increase the QTc-prolonging activities of Telithromycin.Approved, Investigational
PasireotidePasireotide may increase the QTc-prolonging activities of Telithromycin.Approved
PazopanibThe serum concentration of Pazopanib can be increased when it is combined with Telithromycin.Approved
Peginterferon alfa-2bThe serum concentration of Telithromycin can be increased when it is combined with Peginterferon alfa-2b.Approved
PentamidinePentamidine may increase the QTc-prolonging activities of Telithromycin.Approved
PentobarbitalThe metabolism of Telithromycin can be increased when combined with Pentobarbital.Approved, Vet Approved
PerampanelThe metabolism of Perampanel can be decreased when combined with Telithromycin.Approved
PerflutrenPerflutren may increase the QTc-prolonging activities of Telithromycin.Approved
PergolideThe metabolism of Pergolide can be decreased when combined with Telithromycin.Approved, Vet Approved, Withdrawn
PerhexilineThe metabolism of Perhexiline can be decreased when combined with Telithromycin.Approved
PermethrinThe metabolism of Permethrin can be decreased when combined with Telithromycin.Approved, Investigational
PerphenazineThe metabolism of Perphenazine can be decreased when combined with Telithromycin.Approved
PethidineThe metabolism of Pethidine can be decreased when combined with Telithromycin.Approved
PhenacetinThe metabolism of Phenacetin can be decreased when combined with Telithromycin.Withdrawn
PhenindioneThe serum concentration of Phenindione can be increased when it is combined with Telithromycin.Approved
PhenobarbitalThe metabolism of Telithromycin can be increased when combined with Phenobarbital.Approved
PhenoxybenzamineThe metabolism of Phenoxybenzamine can be decreased when combined with Telithromycin.Approved
PhenprocoumonThe metabolism of Phenprocoumon can be decreased when combined with Telithromycin.Approved
PhenytoinThe metabolism of Telithromycin can be increased when combined with Phenytoin.Approved, Vet Approved
Picosulfuric acidThe therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Telithromycin.Approved
PilocarpineThe metabolism of Pilocarpine can be decreased when combined with Telithromycin.Approved
PimecrolimusThe metabolism of Pimecrolimus can be decreased when combined with Telithromycin.Approved, Investigational
PimozideTelithromycin may increase the QTc-prolonging activities of Pimozide.Approved
PinacidilThe metabolism of Pinacidil can be decreased when combined with Telithromycin.Withdrawn
PinaveriumThe metabolism of Pinaverium can be decreased when combined with Telithromycin.Approved
PioglitazoneThe metabolism of Pioglitazone can be decreased when combined with Telithromycin.Approved, Investigational
PipotiazineThe metabolism of Pipotiazine can be decreased when combined with Telithromycin.Approved
PitavastatinThe serum concentration of Pitavastatin can be increased when it is combined with Telithromycin.Approved
PodofiloxThe metabolism of Podofilox can be decreased when combined with Telithromycin.Approved
PomalidomideThe metabolism of Pomalidomide can be decreased when combined with Telithromycin.Approved
PonatinibThe serum concentration of Ponatinib can be increased when it is combined with Telithromycin.Approved
PosaconazoleThe metabolism of Posaconazole can be decreased when combined with Telithromycin.Approved, Investigational, Vet Approved
PranlukastThe serum concentration of Pranlukast can be increased when it is combined with Telithromycin.Approved
PrasteroneThe metabolism of Prasterone can be decreased when combined with Telithromycin.Approved, Nutraceutical
PrasugrelThe serum concentration of the active metabolites of Prasugrel can be reduced when Prasugrel is used in combination with Telithromycin resulting in a loss in efficacy.Approved
PravastatinThe serum concentration of Pravastatin can be increased when it is combined with Telithromycin.Approved
PrazepamThe metabolism of Prazepam can be decreased when combined with Telithromycin.Approved, Illicit
PraziquantelThe metabolism of Praziquantel can be decreased when combined with Telithromycin.Approved, Vet Approved
PrednicarbateThe serum concentration of Prednicarbate can be increased when it is combined with Telithromycin.Approved
PrednisoloneThe metabolism of Prednisolone can be decreased when combined with Telithromycin.Approved, Vet Approved
PrednisoloneThe serum concentration of Prednisolone can be increased when it is combined with Telithromycin.Approved, Vet Approved
PrednisoneThe serum concentration of Prednisone can be increased when it is combined with Telithromycin.Approved, Vet Approved
PregabalinThe metabolism of Pregabalin can be decreased when combined with Telithromycin.Approved, Illicit, Investigational
PregnenoloneThe serum concentration of Pregnenolone can be increased when it is combined with Telithromycin.Experimental
PrenylamineThe metabolism of Prenylamine can be decreased when combined with Telithromycin.Withdrawn
PrimaquineTelithromycin may increase the QTc-prolonging activities of Primaquine.Approved
PrimidoneThe metabolism of Telithromycin can be increased when combined with Primidone.Approved, Vet Approved
ProcainamideTelithromycin may increase the QTc-prolonging activities of Procainamide.Approved
ProchlorperazineThe metabolism of Prochlorperazine can be decreased when combined with Telithromycin.Approved, Vet Approved
ProgesteroneThe metabolism of Progesterone can be decreased when combined with Telithromycin.Approved, Vet Approved
ProguanilThe metabolism of Proguanil can be decreased when combined with Telithromycin.Approved
PromazinePromazine may increase the QTc-prolonging activities of Telithromycin.Approved, Vet Approved
PromethazinePromethazine may increase the QTc-prolonging activities of Telithromycin.Approved
PropafenoneThe serum concentration of Propafenone can be increased when it is combined with Telithromycin.Approved
PropofolThe metabolism of Propofol can be decreased when combined with Telithromycin.Approved, Investigational, Vet Approved
PropranololThe metabolism of Propranolol can be decreased when combined with Telithromycin.Approved, Investigational
ProtriptylineProtriptyline may increase the QTc-prolonging activities of Telithromycin.Approved
PyrazinamideThe metabolism of Pyrazinamide can be decreased when combined with Telithromycin.Approved
QuazepamThe metabolism of Quazepam can be decreased when combined with Telithromycin.Approved, Illicit
QuetiapineThe serum concentration of Quetiapine can be increased when it is combined with Telithromycin.Approved
QuinacrineThe metabolism of Quinacrine can be decreased when combined with Telithromycin.Approved
QuinidineTelithromycin may increase the QTc-prolonging activities of Quinidine.Approved
QuinineThe serum concentration of Quinine can be increased when it is combined with Telithromycin.Approved
RabeprazoleThe metabolism of Rabeprazole can be decreased when combined with Telithromycin.Approved, Investigational
RaloxifeneThe metabolism of Raloxifene can be decreased when combined with Telithromycin.Approved, Investigational
RamelteonThe serum concentration of Ramelteon can be increased when it is combined with Telithromycin.Approved, Investigational
RanolazineThe serum concentration of Ranolazine can be increased when it is combined with Telithromycin.Approved, Investigational
ReboxetineThe metabolism of Reboxetine can be decreased when combined with Telithromycin.Approved, Investigational
RegorafenibThe serum concentration of Regorafenib can be increased when it is combined with Telithromycin.Approved
RepaglinideThe serum concentration of Repaglinide can be increased when it is combined with Telithromycin.Approved, Investigational
RetapamulinThe serum concentration of Retapamulin can be increased when it is combined with Telithromycin.Approved
RifabutinThe metabolism of Telithromycin can be increased when combined with Rifabutin.Approved
RifampicinThe metabolism of Telithromycin can be increased when combined with Rifampicin.Approved
RifapentineThe metabolism of Telithromycin can be increased when combined with Rifapentine.Approved
RilpivirineThe serum concentration of Rilpivirine can be increased when it is combined with Telithromycin.Approved
RimexoloneThe serum concentration of Rimexolone can be increased when it is combined with Telithromycin.Approved
RimonabantThe metabolism of Rimonabant can be decreased when combined with Telithromycin.Approved, Investigational
RiociguatThe metabolism of Riociguat can be decreased when combined with Telithromycin.Approved
RisedronateThe metabolism of Risedronate can be decreased when combined with Telithromycin.Approved, Investigational
RisperidoneThe metabolism of Risperidone can be decreased when combined with Telithromycin.Approved, Investigational
RitonavirThe metabolism of Telithromycin can be decreased when combined with Ritonavir.Approved, Investigational
RivaroxabanThe metabolism of Rivaroxaban can be decreased when combined with Telithromycin.Approved
RofecoxibThe metabolism of Rofecoxib can be decreased when combined with Telithromycin.Investigational, Withdrawn
RolapitantThe metabolism of Rolapitant can be decreased when combined with Telithromycin.Approved
RomidepsinThe serum concentration of Romidepsin can be increased when it is combined with Telithromycin.Approved, Investigational
RopiniroleThe metabolism of Ropinirole can be decreased when combined with Telithromycin.Approved, Investigational
RopivacaineThe metabolism of Ropivacaine can be decreased when combined with Telithromycin.Approved
RosuvastatinThe metabolism of Rosuvastatin can be decreased when combined with Telithromycin.Approved
RotigotineThe metabolism of Rotigotine can be decreased when combined with Telithromycin.Approved
RoxithromycinThe metabolism of Roxithromycin can be decreased when combined with Telithromycin.Approved, Withdrawn
RuxolitinibThe serum concentration of Ruxolitinib can be increased when it is combined with Telithromycin.Approved
SalbutamolSalbutamol may increase the QTc-prolonging activities of Telithromycin.Approved, Vet Approved
SalmeterolThe serum concentration of Salmeterol can be increased when it is combined with Telithromycin.Approved
SaquinavirTelithromycin may increase the QTc-prolonging activities of Saquinavir.Approved, Investigational
SaxagliptinThe serum concentration of Saxagliptin can be increased when it is combined with Telithromycin.Approved
SelegilineThe metabolism of Selegiline can be decreased when combined with Telithromycin.Approved, Investigational, Vet Approved
SelexipagThe metabolism of Selexipag can be decreased when combined with Telithromycin.Approved
SeratrodastThe metabolism of Seratrodast can be decreased when combined with Telithromycin.Approved, Investigational
SertindoleThe metabolism of Sertindole can be decreased when combined with Telithromycin.Approved, Withdrawn
SertralineThe metabolism of Sertraline can be decreased when combined with Telithromycin.Approved
SevofluraneThe metabolism of Sevoflurane can be decreased when combined with Telithromycin.Approved, Vet Approved
SibutramineThe metabolism of Sibutramine can be decreased when combined with Telithromycin.Approved, Illicit, Investigational, Withdrawn
SildenafilThe serum concentration of Sildenafil can be increased when it is combined with Telithromycin.Approved, Investigational
SilodosinThe serum concentration of Silodosin can be increased when it is combined with Telithromycin.Approved
SiltuximabThe serum concentration of Telithromycin can be decreased when it is combined with Siltuximab.Approved
SimeprevirThe serum concentration of Simeprevir can be increased when it is combined with Telithromycin.Approved
SimvastatinThe serum concentration of Simvastatin can be increased when it is combined with Telithromycin.Approved
SirolimusThe metabolism of Sirolimus can be decreased when combined with Telithromycin.Approved, Investigational
SitagliptinThe metabolism of Sitagliptin can be decreased when combined with Telithromycin.Approved, Investigational
SolifenacinThe metabolism of Solifenacin can be decreased when combined with Telithromycin.Approved
SonidegibThe serum concentration of Sonidegib can be increased when it is combined with Telithromycin.Approved, Investigational
SorafenibThe serum concentration of Sorafenib can be increased when it is combined with Telithromycin.Approved, Investigational
SotalolTelithromycin may increase the QTc-prolonging activities of Sotalol.Approved
SpiramycinThe metabolism of Spiramycin can be decreased when combined with Telithromycin.Approved
St. John's WortThe serum concentration of Telithromycin can be decreased when it is combined with St. John's Wort.Nutraceutical
StiripentolThe serum concentration of Telithromycin can be increased when it is combined with Stiripentol.Approved
SufentanilThe metabolism of Sufentanil can be decreased when combined with Telithromycin.Approved, Investigational
SulfadiazineThe metabolism of Sulfadiazine can be decreased when combined with Telithromycin.Approved, Vet Approved
SulfamethoxazoleThe metabolism of Sulfamethoxazole can be decreased when combined with Telithromycin.Approved
SulfinpyrazoneThe metabolism of Sulfinpyrazone can be decreased when combined with Telithromycin.Approved
SulfisoxazoleSulfisoxazole may increase the QTc-prolonging activities of Telithromycin.Approved, Vet Approved
SunitinibThe metabolism of Sunitinib can be decreased when combined with Telithromycin.Approved, Investigational
SuvorexantThe serum concentration of Suvorexant can be increased when it is combined with Telithromycin.Approved
Synthetic Conjugated Estrogens, AThe metabolism of Synthetic Conjugated Estrogens, A can be decreased when combined with Telithromycin.Approved
Synthetic Conjugated Estrogens, BThe metabolism of Synthetic Conjugated Estrogens, B can be decreased when combined with Telithromycin.Approved
TacrolimusThe metabolism of Tacrolimus can be decreased when combined with Telithromycin.Approved, Investigational
TacrolimusThe serum concentration of Tacrolimus can be increased when it is combined with Telithromycin.Approved, Investigational
TadalafilThe serum concentration of Tadalafil can be increased when it is combined with Telithromycin.Approved, Investigational
TamoxifenThe metabolism of Tamoxifen can be decreased when combined with Telithromycin.Approved
TamsulosinThe serum concentration of Tamsulosin can be increased when it is combined with Telithromycin.Approved, Investigational
TasimelteonThe serum concentration of Tasimelteon can be increased when it is combined with Telithromycin.Approved
TasosartanThe metabolism of Tasosartan can be decreased when combined with Telithromycin.Approved
Taurochenodeoxycholic acidThe metabolism of Taurochenodeoxycholic acid can be decreased when combined with Telithromycin.Experimental
TelaprevirThe serum concentration of Telaprevir can be increased when it is combined with Telithromycin.Approved
TelavancinTelithromycin may increase the QTc-prolonging activities of Telavancin.Approved
TemazepamThe metabolism of Temazepam can be decreased when combined with Telithromycin.Approved
TemsirolimusThe risk or severity of adverse effects can be increased when Telithromycin is combined with Temsirolimus.Approved
TeniposideThe metabolism of Teniposide can be decreased when combined with Telithromycin.Approved
TenofovirThe metabolism of Telithromycin can be decreased when combined with Tenofovir.Approved, Investigational
TerbinafineThe metabolism of Terbinafine can be decreased when combined with Telithromycin.Approved, Investigational, Vet Approved
TerbutalineTerbutaline may increase the QTc-prolonging activities of Telithromycin.Approved
TerfenadineTelithromycin may increase the QTc-prolonging activities of Terfenadine.Withdrawn
TeriflunomideThe serum concentration of Telithromycin can be decreased when it is combined with Teriflunomide.Approved
TesmilifeneThe metabolism of Tesmilifene can be decreased when combined with Telithromycin.Investigational
TestosteroneThe metabolism of Testosterone can be decreased when combined with Telithromycin.Approved, Investigational
TetrabenazineTelithromycin may increase the QTc-prolonging activities of Tetrabenazine.Approved
TetracyclineThe metabolism of Tetracycline can be decreased when combined with Telithromycin.Approved, Vet Approved
TheophyllineThe metabolism of Theophylline can be decreased when combined with Telithromycin.Approved
ThioridazineThe serum concentration of Thioridazine can be increased when it is combined with Telithromycin.Approved
ThiotepaThe metabolism of Thiotepa can be decreased when combined with Telithromycin.Approved
ThiothixeneThiothixene may increase the QTc-prolonging activities of Telithromycin.Approved
TiagabineThe metabolism of Tiagabine can be decreased when combined with Telithromycin.Approved
TicagrelorThe serum concentration of the active metabolites of Ticagrelor can be reduced when Ticagrelor is used in combination with Telithromycin resulting in a loss in efficacy.Approved
TiclopidineThe metabolism of Ticlopidine can be decreased when combined with Telithromycin.Approved
TinidazoleThe metabolism of Tinidazole can be decreased when combined with Telithromycin.Approved, Investigational
TiotropiumThe metabolism of Tiotropium can be decreased when combined with Telithromycin.Approved
TipranavirThe metabolism of Tipranavir can be decreased when combined with Telithromycin.Approved, Investigational
TixocortolThe serum concentration of Tixocortol can be increased when it is combined with Telithromycin.Approved
TizanidineTizanidine may increase the QTc-prolonging activities of Telithromycin.Approved
TocilizumabThe serum concentration of Telithromycin can be decreased when it is combined with Tocilizumab.Approved
TofacitinibThe serum concentration of Tofacitinib can be increased when it is combined with Telithromycin.Approved, Investigational
Tolfenamic AcidThe metabolism of Tolfenamic Acid can be decreased when combined with Telithromycin.Approved
TolterodineThe serum concentration of Tolterodine can be increased when it is combined with Telithromycin.Approved, Investigational
TolvaptanThe serum concentration of Tolvaptan can be increased when it is combined with Telithromycin.Approved
ToremifeneThe risk or severity of adverse effects can be increased when Telithromycin is combined with Toremifene.Approved, Investigational
TrabectedinThe serum concentration of Trabectedin can be increased when it is combined with Telithromycin.Approved, Investigational
TramadolThe serum concentration of Tramadol can be increased when it is combined with Telithromycin.Approved, Investigational
TranilastThe metabolism of Tranilast can be decreased when combined with Telithromycin.Approved, Investigational
Trastuzumab emtansineThe serum concentration of the active metabolites of Trastuzumab emtansine can be increased when Trastuzumab emtansine is used in combination with Telithromycin.Approved
TrazodoneThe metabolism of Trazodone can be decreased when combined with Telithromycin.Approved, Investigational
TreprostinilTreprostinil may increase the QTc-prolonging activities of Telithromycin.Approved, Investigational
TretinoinThe metabolism of Tretinoin can be decreased when combined with Telithromycin.Approved, Investigational, Nutraceutical
TriamcinoloneThe metabolism of Triamcinolone can be decreased when combined with Telithromycin.Approved, Vet Approved
TriazolamThe serum concentration of Triazolam can be increased when it is combined with Telithromycin.Approved
TrimethadioneThe metabolism of Trimethadione can be decreased when combined with Telithromycin.Approved
TrimethoprimThe metabolism of Trimethoprim can be decreased when combined with Telithromycin.Approved, Vet Approved
TrimipramineThe metabolism of Trimipramine can be decreased when combined with Telithromycin.Approved
TriptorelinTriptorelin may increase the QTc-prolonging activities of Telithromycin.Approved, Vet Approved
TroglitazoneThe metabolism of Troglitazone can be decreased when combined with Telithromycin.Withdrawn
TroleandomycinThe metabolism of Troleandomycin can be decreased when combined with Telithromycin.Approved
UdenafilThe metabolism of Udenafil can be decreased when combined with Telithromycin.Approved, Investigational
UlipristalThe serum concentration of Ulipristal can be increased when it is combined with Telithromycin.Approved
ValdecoxibThe metabolism of Valdecoxib can be decreased when combined with Telithromycin.Investigational, Withdrawn
VandetanibTelithromycin may increase the QTc-prolonging activities of Vandetanib.Approved
VanoxerineThe metabolism of Vanoxerine can be decreased when combined with Telithromycin.Investigational
VardenafilThe serum concentration of Vardenafil can be increased when it is combined with Telithromycin.Approved
VemurafenibThe serum concentration of Vemurafenib can be increased when it is combined with Telithromycin.Approved
VenetoclaxThe metabolism of Venetoclax can be decreased when combined with Telithromycin.Approved
VenlafaxineThe metabolism of Venlafaxine can be decreased when combined with Telithromycin.Approved
VerapamilTelithromycin may increase the bradycardic activities of Verapamil.Approved
VicrivirocThe metabolism of Vicriviroc can be decreased when combined with Telithromycin.Investigational
VilanterolThe metabolism of Vilanterol can be decreased when combined with Telithromycin.Approved
VilazodoneThe serum concentration of Vilazodone can be increased when it is combined with Telithromycin.Approved
VinblastineThe metabolism of Vinblastine can be decreased when combined with Telithromycin.Approved
VincristineThe serum concentration of Vincristine can be increased when it is combined with Telithromycin.Approved, Investigational
VincristineThe metabolism of Vincristine can be decreased when combined with Telithromycin.Approved, Investigational
VindesineThe serum concentration of Vindesine can be increased when it is combined with Telithromycin.Approved
VinorelbineThe metabolism of Vinorelbine can be decreased when combined with Telithromycin.Approved, Investigational
VinpocetineThe metabolism of Vinpocetine can be decreased when combined with Telithromycin.Investigational
VismodegibThe metabolism of Vismodegib can be decreased when combined with Telithromycin.Approved
VorapaxarThe serum concentration of Vorapaxar can be increased when it is combined with Telithromycin.Approved
VoriconazoleThe metabolism of Telithromycin can be decreased when combined with Voriconazole.Approved, Investigational
VorinostatVorinostat may increase the QTc-prolonging activities of Telithromycin.Approved, Investigational
VortioxetineThe metabolism of Vortioxetine can be decreased when combined with Telithromycin.Approved
WarfarinThe metabolism of Warfarin can be decreased when combined with Telithromycin.Approved
XylometazolineThe metabolism of Xylometazoline can be decreased when combined with Telithromycin.Approved
YohimbineThe metabolism of Yohimbine can be decreased when combined with Telithromycin.Approved, Vet Approved
ZafirlukastThe metabolism of Zafirlukast can be decreased when combined with Telithromycin.Approved, Investigational
ZalcitabineThe metabolism of Zalcitabine can be decreased when combined with Telithromycin.Approved
ZaleplonThe metabolism of Zaleplon can be decreased when combined with Telithromycin.Approved, Illicit, Investigational
ZiconotideThe metabolism of Ziconotide can be decreased when combined with Telithromycin.Approved
ZidovudineThe metabolism of Zidovudine can be decreased when combined with Telithromycin.Approved
ZileutonThe metabolism of Zileuton can be decreased when combined with Telithromycin.Approved, Investigational, Withdrawn
ZiprasidoneTelithromycin may increase the QTc-prolonging activities of Ziprasidone.Approved
ZolpidemThe metabolism of Zolpidem can be decreased when combined with Telithromycin.Approved
ZomepiracThe metabolism of Zomepirac can be decreased when combined with Telithromycin.Withdrawn
ZonisamideThe metabolism of Zonisamide can be decreased when combined with Telithromycin.Approved, Investigational
ZopicloneThe serum concentration of Zopiclone can be increased when it is combined with Telithromycin.Approved
ZuclopenthixolThe serum concentration of Zuclopenthixol can be increased when it is combined with Telithromycin.Approved, Investigational
Food Interactions
  • Take without regard to meals.
References
Synthesis Reference

Suhas Sohani, Mandar Deodhar, Nishant Patel, Manish Patel, Mahesh Davadra, Vinodhamar Kansal, “Process for the Preparation of Telithromycin.” U.S. Patent US20070260066, issued November 08, 2007.

US20070260066
General References
  1. Clay KD, Hanson JS, Pope SD, Rissmiller RW, Purdum PP 3rd, Banks PM: Brief communication: severe hepatotoxicity of telithromycin: three case reports and literature review. Ann Intern Med. 2006 Mar 21;144(6):415-20. Epub 2006 Feb 15. [PubMed:16481451 ]
External Links
ATC CodesJ01FA15
AHFS Codes
  • 08:12.12.12
PDB EntriesNot Available
FDA labelDownload (1.6 MB)
MSDSDownload (201 KB)
ADMET
Predicted ADMET features
PropertyValueProbability
Human Intestinal Absorption+0.9904
Blood Brain Barrier-0.8608
Caco-2 permeable-0.8958
P-glycoprotein substrateSubstrate0.8472
P-glycoprotein inhibitor IInhibitor0.8737
P-glycoprotein inhibitor IIInhibitor0.7653
Renal organic cation transporterNon-inhibitor0.8479
CYP450 2C9 substrateNon-substrate0.7872
CYP450 2D6 substrateNon-substrate0.8617
CYP450 3A4 substrateSubstrate0.7538
CYP450 1A2 substrateNon-inhibitor0.8288
CYP450 2C9 inhibitorNon-inhibitor0.7157
CYP450 2D6 inhibitorNon-inhibitor0.8675
CYP450 2C19 inhibitorNon-inhibitor0.6476
CYP450 3A4 inhibitorNon-inhibitor0.8407
CYP450 inhibitory promiscuityLow CYP Inhibitory Promiscuity0.7749
Ames testNon AMES toxic0.7687
CarcinogenicityNon-carcinogens0.8998
BiodegradationNot ready biodegradable1.0
Rat acute toxicity2.7843 LD50, mol/kg Not applicable
hERG inhibition (predictor I)Weak inhibitor0.9399
hERG inhibition (predictor II)Non-inhibitor0.6053
ADMET data is predicted using admetSAR, a free tool for evaluating chemical ADMET properties. (23092397 )
Pharmacoeconomics
ManufacturersNot Available
Packagers
Dosage forms
FormRouteStrength
TabletOral400 mg
Tablet, film coatedOral300 mg/1
Tablet, film coatedOral400 mg/1
Prices
Unit descriptionCostUnit
Ketek pak 400 mg tablet6.12USD tablet
Ketek 400 mg tablet5.87USD tablet
Ketek 300 mg tablet5.76USD tablet
DrugBank does not sell nor buy drugs. Pricing information is supplied for informational purposes only.
Patents
Patent NumberPediatric ExtensionApprovedExpires (estimated)
CA2102457 No2002-01-222013-11-04Canada
CA2189271 No2005-12-272015-05-02Canada
US5635485 No1998-04-012018-04-01Us
USD459798 No1995-09-242015-09-24Us
Properties
StateSolid
Experimental Properties
PropertyValueSource
melting point176-188 °CNot Available
water solubility300 mg/LNot Available
logP3Not Available
Predicted Properties
PropertyValueSource
Water Solubility0.0283 mg/mLALOGPS
logP4.21ALOGPS
logP5.13ChemAxon
logS-4.5ALOGPS
pKa (Strongest Acidic)8.84ChemAxon
pKa (Strongest Basic)7.65ChemAxon
Physiological Charge1ChemAxon
Hydrogen Acceptor Count11ChemAxon
Hydrogen Donor Count1ChemAxon
Polar Surface Area171.85 Å2ChemAxon
Rotatable Bond Count11ChemAxon
Refractivity214.68 m3·mol-1ChemAxon
Polarizability90.44 Å3ChemAxon
Number of Rings5ChemAxon
Bioavailability0ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleYesChemAxon
Spectra
Mass Spec (NIST)Not Available
SpectraNot Available
Taxonomy
DescriptionThis compound belongs to the class of organic compounds known as aminoglycosides. These are molecules or a portion of a molecule composed of amino-modified sugars.
KingdomOrganic compounds
Super ClassOrganic oxygen compounds
ClassOrganooxygen compounds
Sub ClassCarbohydrates and carbohydrate conjugates
Direct ParentAminoglycosides
Alternative Parents
Substituents
  • Aminoglycoside core
  • N-substituted imidazole
  • Oxane
  • Oxazolidinone
  • Pyridine
  • 1,3-dicarbonyl compound
  • Azole
  • Cyclic alcohol
  • Imidazole
  • Oxazolidine
  • Heteroaromatic compound
  • Carbamic acid ester
  • 1,2-aminoalcohol
  • Carboxylic acid ester
  • Tertiary amine
  • Ketone
  • Lactone
  • Tertiary aliphatic amine
  • Cyclic ketone
  • Amino acid or derivatives
  • Secondary alcohol
  • Monocarboxylic acid or derivatives
  • Ether
  • Azacycle
  • Carboxylic acid derivative
  • Organoheterocyclic compound
  • Acetal
  • Oxacycle
  • Dialkyl ether
  • Amine
  • Carbonyl group
  • Alcohol
  • Organic oxide
  • Organic nitrogen compound
  • Organonitrogen compound
  • Hydrocarbon derivative
  • Aromatic heteropolycyclic compound
Molecular FrameworkAromatic heteropolycyclic compounds
External DescriptorsNot Available

Targets

1. 23S rRNA
Kind
Nucleotide
Organism
Enteric bacteria and other eubacteria
Pharmacological action
yes
Actions
inhibitor
References
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284 ]
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423 ]
  3. Reinert RR, Al-Lahham A: Time-kill study of the activity of telithromycin against macrolide-resistant Streptococcus pneumoniae Isolates with 23S rRNA mutations and changes in ribosomal proteins L4 and L22. Antimicrob Agents Chemother. 2005 Jul;49(7):3011-3. [PubMed:15980387 ]
  4. Farrell DJ, Shackcloth J, Barbadora KA, Green MD: Streptococcus pyogenes isolates with high-level macrolide resistance and reduced susceptibility to telithromycin associated with 23S rRNA mutations. Antimicrob Agents Chemother. 2006 Feb;50(2):817-8. [PubMed:16436755 ]
  5. Hirakata Y, Mizuta Y, Wada A, Kondoh A, Kurihara S, Izumikawa K, Seki M, Yanagihara K, Miyazaki Y, Tomono K, Kohno S: The first telithromycin-resistant Streptococcus pneumoniae isolate in Japan associated with erm(B) and mutations in 23S rRNA and riboprotein L4. Jpn J Infect Dis. 2007 Feb;60(1):48-50. [PubMed:17314426 ]
  6. Champney WS, Mentens N, Zurawick K: An examination of the differential sensitivity to ketolide antibiotics in ermB strains of Streptococcus pyogenes and Streptococcus pneumoniae. Curr Microbiol. 2004 Oct;49(4):239-47. [PubMed:15386111 ]

Enzymes

Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrateinhibitor
General Function:
Vitamin d3 25-hydroxylase activity
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It performs a variety of oxidation reactions (e.g. caffeine 8-oxidation, omeprazole sulphoxidation, midazolam 1'-hydroxylation and midazolam 4-hydroxylation) of structurally unrelated compounds, including steroids, fatty acids, and xenobiot...
Gene Name:
CYP3A4
Uniprot ID:
P08684
Molecular Weight:
57342.67 Da
References
  1. Bearden DT, Neuhauser MM, Garey KW: Telithromycin: an oral ketolide for respiratory infections. Pharmacotherapy. 2001 Oct;21(10):1204-22. [PubMed:11601667 ]
  2. Zhanel GG, Walters M, Noreddin A, Vercaigne LM, Wierzbowski A, Embil JM, Gin AS, Douthwaite S, Hoban DJ: The ketolides: a critical review. Drugs. 2002;62(12):1771-804. [PubMed:12149046 ]
  3. Reed M, Wall GC, Shah NP, Heun JM, Hicklin GA: Verapamil toxicity resulting from a probable interaction with telithromycin. Ann Pharmacother. 2005 Feb;39(2):357-60. Epub 2004 Dec 14. [PubMed:15598962 ]
  4. Shi J, Chapel S, Montay G, Hardy P, Barrett JS, Sica D, Swan SK, Noveck R, Leroy B, Bhargava VO: Effect of ketoconazole on the pharmacokinetics and safety of telithromycin and clarithromycin in older subjects with renal impairment. Int J Clin Pharmacol Ther. 2005 Mar;43(3):123-33. [PubMed:15792396 ]
  5. Nguyen M, Chung EP: Telithromycin: the first ketolide antimicrobial. Clin Ther. 2005 Aug;27(8):1144-63. [PubMed:16199242 ]
  6. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
  7. Drug Interactions: Cytochrome P450 Drug Interaction Table [Link]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrate
General Function:
Oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. Most active in catalyzing 2-hydroxylation. Caffeine is metabolized primarily by cytochrome CYP1A2 in the liver through an initial N...
Gene Name:
CYP1A2
Uniprot ID:
P05177
Molecular Weight:
58293.76 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrateinhibitor
General Function:
Oxygen binding
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
Gene Name:
CYP3A5
Uniprot ID:
P20815
Molecular Weight:
57108.065 Da
References
  1. Drug Interactions: Cytochrome P450 Drug Interaction Table [Link]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrateinhibitor
General Function:
Oxygen binding
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
Gene Name:
CYP3A7
Uniprot ID:
P24462
Molecular Weight:
57525.03 Da
References
  1. Drug Interactions: Cytochrome P450 Drug Interaction Table [Link]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Steroid hydroxylase activity
Specific Function:
Responsible for the metabolism of many drugs and environmental chemicals that it oxidizes. It is involved in the metabolism of drugs such as antiarrhythmics, adrenoceptor antagonists, and tricyclic antidepressants.
Gene Name:
CYP2D6
Uniprot ID:
P10635
Molecular Weight:
55768.94 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
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Drug created on June 13, 2005 07:24 / Updated on December 04, 2016 02:43