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IdentificationPharmacologyInteractionsReferencesTrialsEconomicsPropertiesSpectraTaxonomyFusidic Acid
Identification
- Name
- Fusidic Acid
- Accession Number
- DB02703 (EXPT01507)
- Type
- Small Molecule
- Groups
- Approved, Investigational
- Description
An antibiotic isolated from the fermentation broth of Fusidium coccineum. (From Merck Index, 11th ed) It acts by inhibiting translocation during protein synthesis.
- Structure
Structure for DB02703 (Fusidic Acid)
- Synonyms
- Fucidate
- Fucidin acid
- Fusidate
- Fusidic acid
- Fusidine
- Ramycin
- External IDs
- NSC-56192 / SQ 16,603 / SQ-16603
- Product Ingredients
Ingredient UNII CAS InChI Key Fucidate Sodium J7P3696BCQ 751-94-0 IECPWNUMDGFDKC-MZJAQBGESA-N - Prescription Products
Name Dosage Strength Route Labeller Marketing Start Marketing End Fucidin Cream 2% Cream 2 % Topical Leo Pharma 1984-12-31 Not applicable Canada 
Fucidin Film Coated Tab 250mg Tablet 250 mg Oral Leo Pharma 1991-12-31 2009-06-05 Canada Fucidin Intertulle 2% Dressing 2 % Topical Leo Pharma 1984-12-31 2004-07-23 Canada Fucidin Leo Sus 246mg/5ml Suspension 246 mg Oral Leo Pharma 1980-12-31 2004-07-23 Canada Fucidin Ointment 2% Ointment 2 % Topical Leo Pharma 1984-12-31 Not applicable Canada Fucithalmic Solution / drops 1 % Ophthalmic Amdipharm Limited 2001-08-29 Not applicable Canada Fucithalmic Solution / drops 1 % Ophthalmic Amdipharm Limited 2001-08-07 2017-07-17 Canada - Mixture Products
Name Ingredients Dosage Route Labeller Marketing Start Marketing End Fucidin H Fusidic Acid (2 %) + Hydrocortisone acetate (1 %) Cream Topical Leo Pharma 1998-11-11 Not applicable Canada Fucidin Leo Injection Kit Fucidate Sodium (500 mg) + Sodium phosphate, dibasic, anhydrous (10 ml) Kit Intravenous Leo Pharma 1984-12-31 2004-08-01 Canada - International/Other Brands
- Fucidin / Fucidine / Fudic / Taksta
- Categories
- UNII
- 59XE10C19C
- CAS number
- 6990-06-3
- Weight
- Average: 516.7092
Monoisotopic: 516.345089268 - Chemical Formula
- C31H48O6
- InChI Key
- IECPWNUMDGFDKC-MZJAQBGESA-N
- InChI
- InChI=1S/C31H48O6/c1-17(2)9-8-10-20(28(35)36)26-22-15-24(34)27-29(5)13-12-23(33)18(3)21(29)11-14-30(27,6)31(22,7)16-25(26)37-19(4)32/h9,18,21-25,27,33-34H,8,10-16H2,1-7H3,(H,35,36)/b26-20-/t18-,21-,22-,23+,24+,25-,27-,29-,30-,31-/m0/s1
- IUPAC Name
- 2-[(1S,2S,5R,6S,7S,10S,11S,13S,14Z,15R,17R)-13-(acetyloxy)-5,17-dihydroxy-2,6,10,11-tetramethyltetracyclo[8.7.0.0²,⁷.0¹¹,¹⁵]heptadecan-14-ylidene]-6-methylhept-5-enoic acid
- SMILES
- O[[email protected]@H]1CC[[email protected]@]2(C)[[email protected]@]([H])(CC[[email protected]@]3(C)[[email protected]@]2([H])[[email protected]](O)C[[email protected]@]2([H])\C([[email protected]@H](OC(=O)C)C[[email protected]]32C)=C(/CCC=C(C)C)C(O)=O)[[email protected]@H]1C
Pharmacology
- Indication
For the treatment of bacterial infections.
- Structured Indications
- Pharmacodynamics
Fusidic acid is a bacteriostatic antibiotic that is often used topically in creams and eyedrops, but may also be given systemically as tablets or injections.
- Mechanism of action
Fusidic acid works by interfering with bacterial protein synthesis, specifically by preventing the translocation of the elongation factor G (EF-G) from the ribosome. It also can inhibit chloramphenicol acetyltransferase enzymes.
Target Actions Organism AElongation factor G inhibitorThermus thermophilus UChloramphenicol acetyltransferase inhibitorSalmonella typhi UChloramphenicol acetyltransferase 3 inhibitorEscherichia coli - Absorption
Sodium fusidic acid tablets have a 91% oral bioavailability. Absorption of the film-coated tablets is complete when compared to a solution, however oral absorption is variable. Oral fusidic acid hemihydrate (suspension) achieved a 22.5% bioavailability in pediatric patients following a 20 milligram/kilogram dose.
- Volume of distribution
- Not Available
- Protein binding
97 to 99%
- Metabolism
Metabolites include dicarboxylic ester/acid, 3-keto fusidic acid, hydroxy fusidic acid, glucuronide fusidic acid and a glycol metabolite.
- Route of elimination
- Not Available
- Half life
Approximately 5 to 6 hours in adults.
- Clearance
- Not Available
- Toxicity
- Not Available
- Affected organisms
- Enteric bacteria and other eubacteria
- Pathways
- Not Available
- Pharmacogenomic Effects/ADRs
- Not Available
Interactions
- Drug Interactions
Drug Interaction Drug group Abemaciclib The serum concentration of Abemaciclib can be increased when it is combined with Fusidic Acid. Approved, Investigational Abiraterone The serum concentration of Abiraterone can be increased when it is combined with Fusidic Acid. Approved Acenocoumarol The serum concentration of Acenocoumarol can be increased when it is combined with Fusidic Acid. Approved, Investigational Acetaminophen The serum concentration of Acetaminophen can be increased when it is combined with Fusidic Acid. Approved Adinazolam The serum concentration of Adinazolam can be increased when it is combined with Fusidic Acid. Approved Albendazole The serum concentration of Albendazole can be increased when it is combined with Fusidic Acid. Approved, Vet Approved Alclometasone The serum concentration of Alclometasone can be increased when it is combined with Fusidic Acid. Approved Alfentanil The serum concentration of Alfentanil can be increased when it is combined with Fusidic Acid. Approved, Illicit Alfuzosin The serum concentration of Alfuzosin can be increased when it is combined with Fusidic Acid. Approved, Investigational Aliskiren The serum concentration of Aliskiren can be increased when it is combined with Fusidic Acid. Approved, Investigational Allylestrenol The serum concentration of Allylestrenol can be increased when it is combined with Fusidic Acid. Approved Almotriptan The serum concentration of Almotriptan can be increased when it is combined with Fusidic Acid. Approved, Investigational Alogliptin The serum concentration of Alogliptin can be increased when it is combined with Fusidic Acid. Approved Alosetron The serum concentration of Alosetron can be increased when it is combined with Fusidic Acid. Approved, Withdrawn alpha-Tocopherol acetate The serum concentration of alpha-Tocopherol acetate can be increased when it is combined with Fusidic Acid. Approved Alprazolam The serum concentration of Alprazolam can be increased when it is combined with Fusidic Acid. Approved, Illicit, Investigational Ambrisentan The serum concentration of Ambrisentan can be increased when it is combined with Fusidic Acid. Approved, Investigational Ambroxol The serum concentration of Ambroxol can be increased when it is combined with Fusidic Acid. Approved, Investigational Aminophenazone The serum concentration of Aminophenazone can be increased when it is combined with Fusidic Acid. Approved, Withdrawn Aminophylline The serum concentration of Aminophylline can be increased when it is combined with Fusidic Acid. Approved Amiodarone The serum concentration of Amiodarone can be increased when it is combined with Fusidic Acid. Approved, Investigational Amitriptyline The serum concentration of Amitriptyline can be increased when it is combined with Fusidic Acid. Approved Amlodipine The serum concentration of Amlodipine can be increased when it is combined with Fusidic Acid. Approved Amprenavir The serum concentration of Amprenavir can be increased when it is combined with Fusidic Acid. Approved, Investigational Antipyrine The serum concentration of Antipyrine can be increased when it is combined with Fusidic Acid. Approved, Investigational Apalutamide The serum concentration of Apalutamide can be increased when it is combined with Fusidic Acid. Approved, Investigational Apixaban The serum concentration of Apixaban can be increased when it is combined with Fusidic Acid. Approved Apremilast The serum concentration of Apremilast can be increased when it is combined with Fusidic Acid. Approved, Investigational Aprepitant The serum concentration of Aprepitant can be increased when it is combined with Fusidic Acid. Approved, Investigational Argatroban The serum concentration of Argatroban can be increased when it is combined with Fusidic Acid. Approved, Investigational Aripiprazole The serum concentration of Aripiprazole can be increased when it is combined with Fusidic Acid. Approved, Investigational Artemether The serum concentration of Artemether can be increased when it is combined with Fusidic Acid. Approved Asenapine The serum concentration of Asenapine can be increased when it is combined with Fusidic Acid. Approved Astemizole The serum concentration of Astemizole can be increased when it is combined with Fusidic Acid. Approved, Withdrawn Asunaprevir The serum concentration of Asunaprevir can be increased when it is combined with Fusidic Acid. Approved, Investigational, Withdrawn Atazanavir The serum concentration of Atazanavir can be increased when it is combined with Fusidic Acid. Approved, Investigational Atorvastatin The serum concentration of Atorvastatin can be increased when it is combined with Fusidic Acid. Approved Avanafil The serum concentration of Avanafil can be increased when it is combined with Fusidic Acid. Approved Axitinib The serum concentration of Axitinib can be increased when it is combined with Fusidic Acid. Approved, Investigational Azelastine The serum concentration of Azelastine can be increased when it is combined with Fusidic Acid. Approved Azithromycin The serum concentration of Azithromycin can be increased when it is combined with Fusidic Acid. Approved Banoxantrone The serum concentration of Banoxantrone can be increased when it is combined with Fusidic Acid. Investigational Baricitinib The serum concentration of Baricitinib can be increased when it is combined with Fusidic Acid. Approved, Investigational Bedaquiline The serum concentration of Bedaquiline can be increased when it is combined with Fusidic Acid. Approved Benidipine The serum concentration of Benidipine can be increased when it is combined with Fusidic Acid. Approved, Investigational Benzphetamine The serum concentration of Benzphetamine can be increased when it is combined with Fusidic Acid. Approved, Illicit Benzyl alcohol The serum concentration of Benzyl alcohol can be increased when it is combined with Fusidic Acid. Approved Bexarotene The serum concentration of Bexarotene can be increased when it is combined with Fusidic Acid. Approved, Investigational Bezafibrate The serum concentration of Bezafibrate can be increased when it is combined with Fusidic Acid. Approved, Investigational Bicalutamide The serum concentration of Bicalutamide can be increased when it is combined with Fusidic Acid. Approved Bictegravir The serum concentration of Bictegravir can be increased when it is combined with Fusidic Acid. Approved, Investigational Bisoprolol The serum concentration of Bisoprolol can be increased when it is combined with Fusidic Acid. Approved Blonanserin The serum concentration of Blonanserin can be increased when it is combined with Fusidic Acid. Approved, Investigational Boceprevir The serum concentration of Boceprevir can be increased when it is combined with Fusidic Acid. Approved, Withdrawn Bortezomib The serum concentration of Bortezomib can be increased when it is combined with Fusidic Acid. Approved, Investigational Bosentan The serum concentration of Bosentan can be increased when it is combined with Fusidic Acid. Approved, Investigational Bosutinib The serum concentration of Bosutinib can be increased when it is combined with Fusidic Acid. Approved Brentuximab vedotin The serum concentration of Brentuximab vedotin can be increased when it is combined with Fusidic Acid. Approved, Investigational Brexpiprazole The serum concentration of Brexpiprazole can be increased when it is combined with Fusidic Acid. Approved, Investigational Brigatinib The serum concentration of Brigatinib can be increased when it is combined with Fusidic Acid. Approved, Investigational Brinzolamide The serum concentration of Brinzolamide can be increased when it is combined with Fusidic Acid. Approved Brivaracetam The serum concentration of Brivaracetam can be increased when it is combined with Fusidic Acid. Approved, Investigational Bromazepam The serum concentration of Bromazepam can be increased when it is combined with Fusidic Acid. Approved, Illicit, Investigational Bromocriptine The serum concentration of Bromocriptine can be increased when it is combined with Fusidic Acid. Approved, Investigational Brompheniramine The serum concentration of Brompheniramine can be increased when it is combined with Fusidic Acid. Approved Budesonide The serum concentration of Budesonide can be increased when it is combined with Fusidic Acid. Approved Bupivacaine The serum concentration of Bupivacaine can be increased when it is combined with Fusidic Acid. Approved, Investigational Buprenorphine The serum concentration of Buprenorphine can be increased when it is combined with Fusidic Acid. Approved, Illicit, Investigational, Vet Approved Bupropion The serum concentration of Bupropion can be increased when it is combined with Fusidic Acid. Approved Buspirone The serum concentration of Buspirone can be increased when it is combined with Fusidic Acid. Approved, Investigational Busulfan The serum concentration of Busulfan can be increased when it is combined with Fusidic Acid. Approved, Investigational Cabazitaxel The serum concentration of Cabazitaxel can be increased when it is combined with Fusidic Acid. Approved Cabergoline The serum concentration of Cabergoline can be increased when it is combined with Fusidic Acid. Approved Cabozantinib The serum concentration of Cabozantinib can be increased when it is combined with Fusidic Acid. Approved, Investigational Caffeine The serum concentration of Caffeine can be increased when it is combined with Fusidic Acid. Approved Calcitriol The serum concentration of Calcitriol can be increased when it is combined with Fusidic Acid. Approved, Nutraceutical Canagliflozin The serum concentration of Canagliflozin can be increased when it is combined with Fusidic Acid. Approved Cannabidiol The serum concentration of Cannabidiol can be increased when it is combined with Fusidic Acid. Approved, Investigational Carbamazepine The serum concentration of Carbamazepine can be increased when it is combined with Fusidic Acid. Approved, Investigational Carbinoxamine The serum concentration of Carbinoxamine can be increased when it is combined with Fusidic Acid. Approved Cariprazine The serum concentration of Cariprazine can be increased when it is combined with Fusidic Acid. Approved, Investigational Carvedilol The serum concentration of Carvedilol can be increased when it is combined with Fusidic Acid. Approved, Investigational Celecoxib The serum concentration of Celecoxib can be increased when it is combined with Fusidic Acid. Approved, Investigational Celiprolol The serum concentration of Celiprolol can be increased when it is combined with Fusidic Acid. Approved, Investigational Cephalexin The serum concentration of Cephalexin can be increased when it is combined with Fusidic Acid. Approved, Investigational, Vet Approved Cerivastatin The serum concentration of Cerivastatin can be increased when it is combined with Fusidic Acid. Approved, Withdrawn Cevimeline The serum concentration of Cevimeline can be increased when it is combined with Fusidic Acid. Approved Chenodeoxycholic acid The serum concentration of Chenodeoxycholic acid can be increased when it is combined with Fusidic Acid. Approved Chlordiazepoxide The serum concentration of Chlordiazepoxide can be increased when it is combined with Fusidic Acid. Approved, Illicit, Investigational Chloroquine The serum concentration of Chloroquine can be increased when it is combined with Fusidic Acid. Approved, Investigational, Vet Approved Chlorphenamine The serum concentration of Chlorphenamine can be increased when it is combined with Fusidic Acid. Approved Chlorpromazine The serum concentration of Chlorpromazine can be increased when it is combined with Fusidic Acid. Approved, Investigational, Vet Approved Chlorzoxazone The serum concentration of Chlorzoxazone can be increased when it is combined with Fusidic Acid. Approved Cholecalciferol The serum concentration of Cholecalciferol can be increased when it is combined with Fusidic Acid. Approved, Nutraceutical Cholic Acid Fusidic Acid may decrease the excretion rate of Cholic Acid which could result in a higher serum level. Approved Ciclesonide The serum concentration of Ciclesonide can be increased when it is combined with Fusidic Acid. Approved, Investigational Cilostazol The serum concentration of Cilostazol can be increased when it is combined with Fusidic Acid. Approved, Investigational Cinacalcet The serum concentration of Cinacalcet can be increased when it is combined with Fusidic Acid. Approved Cisapride The serum concentration of Cisapride can be increased when it is combined with Fusidic Acid. Approved, Investigational, Withdrawn Citalopram The serum concentration of Citalopram can be increased when it is combined with Fusidic Acid. Approved Clarithromycin The serum concentration of Clarithromycin can be increased when it is combined with Fusidic Acid. Approved Clindamycin The serum concentration of Clindamycin can be increased when it is combined with Fusidic Acid. Approved, Vet Approved Clobazam The serum concentration of Clobazam can be increased when it is combined with Fusidic Acid. Approved, Illicit Clofazimine The serum concentration of Clofazimine can be increased when it is combined with Fusidic Acid. Approved, Investigational Clofibrate The serum concentration of Clofibrate can be increased when it is combined with Fusidic Acid. Approved, Investigational clomethiazole The serum concentration of clomethiazole can be increased when it is combined with Fusidic Acid. Investigational Clomipramine The serum concentration of Clomipramine can be increased when it is combined with Fusidic Acid. Approved, Investigational, Vet Approved Clonazepam The serum concentration of Clonazepam can be increased when it is combined with Fusidic Acid. Approved, Illicit Clonidine The serum concentration of Clonidine can be increased when it is combined with Fusidic Acid. Approved Clopidogrel The serum concentration of Clopidogrel can be increased when it is combined with Fusidic Acid. Approved Clorazepate The serum concentration of Clorazepate can be increased when it is combined with Fusidic Acid. Approved, Illicit Clorindione The serum concentration of Clorindione can be increased when it is combined with Fusidic Acid. Experimental Clotiazepam The serum concentration of Clotiazepam can be increased when it is combined with Fusidic Acid. Approved, Illicit Clozapine The serum concentration of Clozapine can be increased when it is combined with Fusidic Acid. Approved Cocaine The serum concentration of Cocaine can be increased when it is combined with Fusidic Acid. Approved, Illicit Codeine The serum concentration of Codeine can be increased when it is combined with Fusidic Acid. Approved, Illicit Colchicine The serum concentration of Colchicine can be increased when it is combined with Fusidic Acid. Approved Conivaptan The serum concentration of Conivaptan can be increased when it is combined with Fusidic Acid. Approved, Investigational Conjugated estrogens The serum concentration of Conjugated estrogens can be increased when it is combined with Fusidic Acid. Approved Copanlisib The serum concentration of Copanlisib can be increased when it is combined with Fusidic Acid. Approved, Investigational Cortisone acetate The serum concentration of Cortisone acetate can be increased when it is combined with Fusidic Acid. Approved, Investigational Crizotinib The serum concentration of Crizotinib can be increased when it is combined with Fusidic Acid. Approved Cyclobenzaprine The serum concentration of Cyclobenzaprine can be increased when it is combined with Fusidic Acid. Approved Cyclophosphamide The serum concentration of Cyclophosphamide can be increased when it is combined with Fusidic Acid. Approved, Investigational Cyclosporine The serum concentration of Cyclosporine can be increased when it is combined with Fusidic Acid. Approved, Investigational, Vet Approved Cytarabine The serum concentration of Cytarabine can be increased when it is combined with Fusidic Acid. Approved, Investigational Dabrafenib The serum concentration of Dabrafenib can be increased when it is combined with Fusidic Acid. Approved, Investigational Daclatasvir The serum concentration of Daclatasvir can be increased when it is combined with Fusidic Acid. Approved, Investigational Dantrolene The serum concentration of Dantrolene can be increased when it is combined with Fusidic Acid. Approved, Investigational Dapagliflozin The serum concentration of Dapagliflozin can be increased when it is combined with Fusidic Acid. Approved Dapsone The serum concentration of Dapsone can be increased when it is combined with Fusidic Acid. Approved, Investigational Darifenacin The serum concentration of Darifenacin can be increased when it is combined with Fusidic Acid. Approved, Investigational Darunavir The serum concentration of Darunavir can be increased when it is combined with Fusidic Acid. Approved Dasabuvir The serum concentration of Dasabuvir can be increased when it is combined with Fusidic Acid. Approved Dasatinib The serum concentration of Dasatinib can be increased when it is combined with Fusidic Acid. Approved, Investigational Daunorubicin The serum concentration of Daunorubicin can be increased when it is combined with Fusidic Acid. Approved Deflazacort The serum concentration of Deflazacort can be increased when it is combined with Fusidic Acid. Approved, Investigational Delavirdine The serum concentration of Delavirdine can be increased when it is combined with Fusidic Acid. Approved Desvenlafaxine The serum concentration of Desvenlafaxine can be increased when it is combined with Fusidic Acid. Approved, Investigational Deutetrabenazine The serum concentration of Deutetrabenazine can be increased when it is combined with Fusidic Acid. Approved, Investigational Dexamethasone The serum concentration of Dexamethasone can be increased when it is combined with Fusidic Acid. Approved, Investigational, Vet Approved Dexchlorpheniramine maleate The serum concentration of Dexchlorpheniramine maleate can be increased when it is combined with Fusidic Acid. Approved Dexlansoprazole The serum concentration of Dexlansoprazole can be increased when it is combined with Fusidic Acid. Approved, Investigational Dextromethorphan The serum concentration of Dextromethorphan can be increased when it is combined with Fusidic Acid. Approved Dextropropoxyphene The serum concentration of Dextropropoxyphene can be increased when it is combined with Fusidic Acid. Approved, Illicit, Investigational, Withdrawn Diazepam The serum concentration of Diazepam can be increased when it is combined with Fusidic Acid. Approved, Illicit, Investigational, Vet Approved Diclofenac The serum concentration of Diclofenac can be increased when it is combined with Fusidic Acid. Approved, Vet Approved Dicoumarol The serum concentration of Dicoumarol can be increased when it is combined with Fusidic Acid. Approved Dienogest The serum concentration of Dienogest can be increased when it is combined with Fusidic Acid. Approved Digitoxin The serum concentration of Digitoxin can be increased when it is combined with Fusidic Acid. Approved, Investigational Digoxin The serum concentration of Digoxin can be increased when it is combined with Fusidic Acid. Approved Dihydrocodeine The serum concentration of Dihydrocodeine can be increased when it is combined with Fusidic Acid. Approved, Illicit Dihydroergotamine The serum concentration of Dihydroergotamine can be increased when it is combined with Fusidic Acid. Approved, Investigational Diltiazem The serum concentration of Diltiazem can be increased when it is combined with Fusidic Acid. Approved, Investigational Diphenadione The serum concentration of Diphenadione can be increased when it is combined with Fusidic Acid. Experimental Disopyramide The serum concentration of Disopyramide can be increased when it is combined with Fusidic Acid. Approved Disulfiram The serum concentration of Disulfiram can be increased when it is combined with Fusidic Acid. Approved Docetaxel The serum concentration of Docetaxel can be increased when it is combined with Fusidic Acid. Approved, Investigational Dofetilide The serum concentration of Dofetilide can be increased when it is combined with Fusidic Acid. Approved, Investigational Dolasetron The serum concentration of Dolasetron can be increased when it is combined with Fusidic Acid. Approved, Investigational Domperidone The serum concentration of Domperidone can be increased when it is combined with Fusidic Acid. Approved, Investigational, Vet Approved Donepezil The serum concentration of Donepezil can be increased when it is combined with Fusidic Acid. Approved Dorzolamide The serum concentration of Dorzolamide can be increased when it is combined with Fusidic Acid. Approved Doxepin The serum concentration of Doxepin can be increased when it is combined with Fusidic Acid. Approved, Investigational Doxorubicin The serum concentration of Doxorubicin can be increased when it is combined with Fusidic Acid. Approved, Investigational Dronabinol The serum concentration of Dronabinol can be increased when it is combined with Fusidic Acid. Approved, Illicit Dronedarone The serum concentration of Dronedarone can be increased when it is combined with Fusidic Acid. Approved Dutasteride The serum concentration of Dutasteride can be increased when it is combined with Fusidic Acid. Approved, Investigational Efavirenz The serum concentration of Efavirenz can be increased when it is combined with Fusidic Acid. Approved, Investigational Elbasvir The serum concentration of Elbasvir can be increased when it is combined with Fusidic Acid. Approved Eletriptan The serum concentration of Eletriptan can be increased when it is combined with Fusidic Acid. Approved, Investigational Eliglustat The serum concentration of Eliglustat can be increased when it is combined with Fusidic Acid. Approved Elvitegravir The serum concentration of Elvitegravir can be increased when it is combined with Fusidic Acid. Approved Enalapril The serum concentration of Enalapril can be increased when it is combined with Fusidic Acid. Approved, Vet Approved Enasidenib The serum concentration of Enasidenib can be increased when it is combined with Fusidic Acid. Approved, Investigational Enzalutamide The serum concentration of Enzalutamide can be increased when it is combined with Fusidic Acid. Approved Epinastine The serum concentration of Epinastine can be increased when it is combined with Fusidic Acid. Approved, Investigational Eplerenone The serum concentration of Eplerenone can be increased when it is combined with Fusidic Acid. Approved Ergocalciferol The serum concentration of Ergocalciferol can be increased when it is combined with Fusidic Acid. Approved, Nutraceutical Ergoloid mesylate The serum concentration of Ergoloid mesylate can be increased when it is combined with Fusidic Acid. Approved Ergonovine The serum concentration of Ergonovine can be increased when it is combined with Fusidic Acid. Approved Ergotamine The serum concentration of Ergotamine can be increased when it is combined with Fusidic Acid. Approved Erlotinib The serum concentration of Erlotinib can be increased when it is combined with Fusidic Acid. Approved, Investigational Erythromycin The serum concentration of Erythromycin can be increased when it is combined with Fusidic Acid. Approved, Investigational, Vet Approved Escitalopram The serum concentration of Escitalopram can be increased when it is combined with Fusidic Acid. Approved, Investigational Esomeprazole The serum concentration of Esomeprazole can be increased when it is combined with Fusidic Acid. Approved, Investigational Estazolam The serum concentration of Estazolam can be increased when it is combined with Fusidic Acid. Approved, Illicit Estradiol The serum concentration of Estradiol can be increased when it is combined with Fusidic Acid. Approved, Investigational, Vet Approved Estradiol acetate The serum concentration of Estradiol acetate can be increased when it is combined with Fusidic Acid. Approved, Investigational, Vet Approved Estradiol benzoate The serum concentration of Estradiol benzoate can be increased when it is combined with Fusidic Acid. Approved, Investigational, Vet Approved Estradiol cypionate The serum concentration of Estradiol cypionate can be increased when it is combined with Fusidic Acid. Approved, Investigational, Vet Approved Estradiol dienanthate The serum concentration of Estradiol dienanthate can be increased when it is combined with Fusidic Acid. Approved, Investigational, Vet Approved Estradiol valerate The serum concentration of Estradiol valerate can be increased when it is combined with Fusidic Acid. Approved, Investigational, Vet Approved Estramustine The serum concentration of Estramustine can be increased when it is combined with Fusidic Acid. Approved, Investigational Estrogens, esterified The serum concentration of Estrogens, esterified can be increased when it is combined with Fusidic Acid. Approved Estrone The serum concentration of Estrone can be increased when it is combined with Fusidic Acid. Approved Estrone sulfate The serum concentration of Estrone sulfate can be increased when it is combined with Fusidic Acid. Approved Eszopiclone The serum concentration of Eszopiclone can be increased when it is combined with Fusidic Acid. Approved, Investigational Ethanol The serum concentration of Ethanol can be increased when it is combined with Fusidic Acid. Approved Ethinyl Estradiol The serum concentration of Ethinyl Estradiol can be increased when it is combined with Fusidic Acid. Approved Ethosuximide The serum concentration of Ethosuximide can be increased when it is combined with Fusidic Acid. Approved Ethyl biscoumacetate The serum concentration of Ethyl biscoumacetate can be increased when it is combined with Fusidic Acid. Withdrawn Ethylmorphine The serum concentration of Ethylmorphine can be increased when it is combined with Fusidic Acid. Approved, Illicit Etizolam The serum concentration of Etizolam can be increased when it is combined with Fusidic Acid. Approved Etonogestrel The serum concentration of Etonogestrel can be increased when it is combined with Fusidic Acid. Approved, Investigational Etoposide The serum concentration of Etoposide can be increased when it is combined with Fusidic Acid. Approved Etoricoxib The serum concentration of Etoricoxib can be increased when it is combined with Fusidic Acid. Approved, Investigational Etravirine The serum concentration of Etravirine can be increased when it is combined with Fusidic Acid. Approved Everolimus The serum concentration of Everolimus can be increased when it is combined with Fusidic Acid. Approved Exemestane The serum concentration of Exemestane can be increased when it is combined with Fusidic Acid. Approved, Investigational Famciclovir The serum concentration of Famciclovir can be increased when it is combined with Fusidic Acid. Approved, Investigational Felbamate The serum concentration of Felbamate can be increased when it is combined with Fusidic Acid. Approved Felodipine The serum concentration of Felodipine can be increased when it is combined with Fusidic Acid. Approved, Investigational Fenofibrate The serum concentration of Fenofibrate can be increased when it is combined with Fusidic Acid. Approved Fentanyl The serum concentration of Fentanyl can be increased when it is combined with Fusidic Acid. Approved, Illicit, Investigational, Vet Approved Fesoterodine The serum concentration of Fesoterodine can be increased when it is combined with Fusidic Acid. Approved Finasteride The serum concentration of Finasteride can be increased when it is combined with Fusidic Acid. Approved Fingolimod The serum concentration of Fingolimod can be increased when it is combined with Fusidic Acid. Approved, Investigational Flibanserin The serum concentration of Flibanserin can be increased when it is combined with Fusidic Acid. Approved, Investigational Fluindione The serum concentration of Fluindione can be increased when it is combined with Fusidic Acid. Approved, Investigational Flunisolide The serum concentration of Flunisolide can be increased when it is combined with Fusidic Acid. Approved, Investigational Flunitrazepam The serum concentration of Flunitrazepam can be increased when it is combined with Fusidic Acid. Approved, Illicit Fluorometholone The serum concentration of Fluorometholone can be increased when it is combined with Fusidic Acid. Approved, Investigational Fluoxetine The serum concentration of Fluoxetine can be increased when it is combined with Fusidic Acid. Approved, Vet Approved Flurazepam The serum concentration of Flurazepam can be increased when it is combined with Fusidic Acid. Approved, Illicit, Investigational Flutamide The serum concentration of Flutamide can be increased when it is combined with Fusidic Acid. Approved, Investigational Fluticasone furoate The serum concentration of Fluticasone furoate can be increased when it is combined with Fusidic Acid. Approved Fluticasone propionate The serum concentration of Fluticasone propionate can be increased when it is combined with Fusidic Acid. Approved Fluvastatin The serum concentration of Fluvastatin can be increased when it is combined with Fusidic Acid. Approved Fosamprenavir The serum concentration of Fosamprenavir can be increased when it is combined with Fusidic Acid. Approved Fulvestrant The serum concentration of Fulvestrant can be increased when it is combined with Fusidic Acid. Approved, Investigational Galantamine The serum concentration of Galantamine can be increased when it is combined with Fusidic Acid. Approved Gefitinib The serum concentration of Gefitinib can be increased when it is combined with Fusidic Acid. Approved, Investigational Gemfibrozil The serum concentration of Gemfibrozil can be increased when it is combined with Fusidic Acid. Approved Glipizide The serum concentration of Glipizide can be increased when it is combined with Fusidic Acid. Approved, Investigational Glyburide The serum concentration of Glyburide can be increased when it is combined with Fusidic Acid. Approved Granisetron The serum concentration of Granisetron can be increased when it is combined with Fusidic Acid. Approved, Investigational Grazoprevir The serum concentration of Grazoprevir can be increased when it is combined with Fusidic Acid. Approved Grepafloxacin The serum concentration of Grepafloxacin can be increased when it is combined with Fusidic Acid. Approved, Investigational, Withdrawn Guanfacine The serum concentration of Guanfacine can be increased when it is combined with Fusidic Acid. Approved, Investigational Halofantrine The serum concentration of Halofantrine can be increased when it is combined with Fusidic Acid. Approved Haloperidol The serum concentration of Haloperidol can be increased when it is combined with Fusidic Acid. Approved Halothane The serum concentration of Halothane can be increased when it is combined with Fusidic Acid. Approved, Vet Approved Hexobarbital The serum concentration of Hexobarbital can be increased when it is combined with Fusidic Acid. Approved Histamine The serum concentration of Histamine can be increased when it is combined with Fusidic Acid. Approved, Investigational Hydrocodone The serum concentration of Hydrocodone can be increased when it is combined with Fusidic Acid. Approved, Illicit Hydrocortisone The serum concentration of Hydrocortisone can be increased when it is combined with Fusidic Acid. Approved, Vet Approved Hydromorphone The serum concentration of Hydromorphone can be increased when it is combined with Fusidic Acid. Approved, Illicit Hydroxyprogesterone caproate The serum concentration of Hydroxyprogesterone caproate can be increased when it is combined with Fusidic Acid. Approved, Investigational Ibrutinib The serum concentration of Ibrutinib can be increased when it is combined with Fusidic Acid. Approved Icotinib The serum concentration of Icotinib can be increased when it is combined with Fusidic Acid. Approved, Investigational Ifosfamide The serum concentration of Ifosfamide can be increased when it is combined with Fusidic Acid. Approved Iloperidone The serum concentration of Iloperidone can be increased when it is combined with Fusidic Acid. Approved Imatinib The serum concentration of Imatinib can be increased when it is combined with Fusidic Acid. Approved Imidafenacin The serum concentration of Imidafenacin can be increased when it is combined with Fusidic Acid. Approved, Investigational Imipramine The serum concentration of Imipramine can be increased when it is combined with Fusidic Acid. Approved Imiquimod The serum concentration of Imiquimod can be increased when it is combined with Fusidic Acid. Approved, Investigational Indacaterol The serum concentration of Indacaterol can be increased when it is combined with Fusidic Acid. Approved Indapamide The serum concentration of Indapamide can be increased when it is combined with Fusidic Acid. Approved Indinavir The serum concentration of Indinavir can be increased when it is combined with Fusidic Acid. Approved Ipratropium bromide The serum concentration of Ipratropium bromide can be increased when it is combined with Fusidic Acid. Approved Irinotecan The serum concentration of Irinotecan can be increased when it is combined with Fusidic Acid. Approved, Investigational Isavuconazole The serum concentration of Isavuconazole can be increased when it is combined with Fusidic Acid. Approved, Investigational Isavuconazonium The serum concentration of Isavuconazonium can be increased when it is combined with Fusidic Acid. Approved, Investigational Isosorbide Dinitrate The serum concentration of Isosorbide Dinitrate can be increased when it is combined with Fusidic Acid. Approved, Investigational Isosorbide Mononitrate The serum concentration of Isosorbide Mononitrate can be increased when it is combined with Fusidic Acid. Approved Isradipine The serum concentration of Isradipine can be increased when it is combined with Fusidic Acid. Approved, Investigational Itraconazole The serum concentration of Itraconazole can be increased when it is combined with Fusidic Acid. Approved, Investigational Ivabradine The serum concentration of Ivabradine can be increased when it is combined with Fusidic Acid. Approved Ivacaftor The serum concentration of Ivacaftor can be increased when it is combined with Fusidic Acid. Approved Ivermectin The serum concentration of Ivermectin can be increased when it is combined with Fusidic Acid. Approved, Investigational, Vet Approved Ixabepilone The serum concentration of Ixabepilone can be increased when it is combined with Fusidic Acid. Approved, Investigational Ixazomib The serum concentration of Ixazomib can be increased when it is combined with Fusidic Acid. Approved, Investigational Ketamine The serum concentration of Ketamine can be increased when it is combined with Fusidic Acid. Approved, Vet Approved Ketazolam The serum concentration of Ketazolam can be increased when it is combined with Fusidic Acid. Approved Ketobemidone The serum concentration of Ketobemidone can be increased when it is combined with Fusidic Acid. Approved, Investigational Ketoconazole The serum concentration of Ketoconazole can be increased when it is combined with Fusidic Acid. Approved, Investigational Lacidipine The serum concentration of Lacidipine can be increased when it is combined with Fusidic Acid. Approved, Investigational Lansoprazole The serum concentration of Lansoprazole can be increased when it is combined with Fusidic Acid. Approved, Investigational Lapatinib The serum concentration of Lapatinib can be increased when it is combined with Fusidic Acid. Approved, Investigational Laquinimod The serum concentration of Laquinimod can be increased when it is combined with Fusidic Acid. Investigational Lenvatinib The serum concentration of Lenvatinib can be increased when it is combined with Fusidic Acid. Approved, Investigational Lercanidipine The serum concentration of Lercanidipine can be increased when it is combined with Fusidic Acid. Approved, Investigational Letrozole The serum concentration of Letrozole can be increased when it is combined with Fusidic Acid. Approved, Investigational Levobupivacaine The serum concentration of Levobupivacaine can be increased when it is combined with Fusidic Acid. Approved, Investigational Levocetirizine The serum concentration of Levocetirizine can be increased when it is combined with Fusidic Acid. Approved Levomethadyl Acetate The serum concentration of Levomethadyl Acetate can be increased when it is combined with Fusidic Acid. Approved, Investigational Levomilnacipran The serum concentration of Levomilnacipran can be increased when it is combined with Fusidic Acid. Approved, Investigational Levonorgestrel The serum concentration of Levonorgestrel can be increased when it is combined with Fusidic Acid. Approved, Investigational Levothyroxine The serum concentration of Levothyroxine can be increased when it is combined with Fusidic Acid. Approved Lidocaine The serum concentration of Lidocaine can be increased when it is combined with Fusidic Acid. Approved, Vet Approved Lisuride The serum concentration of Lisuride can be increased when it is combined with Fusidic Acid. Approved, Investigational Lomitapide The serum concentration of Lomitapide can be increased when it is combined with Fusidic Acid. Approved, Investigational Loperamide The serum concentration of Loperamide can be increased when it is combined with Fusidic Acid. Approved Lopinavir The serum concentration of Lopinavir can be increased when it is combined with Fusidic Acid. Approved Loratadine The serum concentration of Loratadine can be increased when it is combined with Fusidic Acid. Approved, Investigational Lorcaserin The serum concentration of Lorcaserin can be increased when it is combined with Fusidic Acid. Approved Lorpiprazole The serum concentration of Lorpiprazole can be increased when it is combined with Fusidic Acid. Approved Losartan The serum concentration of Losartan can be increased when it is combined with Fusidic Acid. Approved Lovastatin The serum concentration of Lovastatin can be increased when it is combined with Fusidic Acid. Approved, Investigational Lumefantrine The serum concentration of Lumefantrine can be increased when it is combined with Fusidic Acid. Approved Lurasidone The serum concentration of Lurasidone can be increased when it is combined with Fusidic Acid. Approved, Investigational Macimorelin The serum concentration of Macimorelin can be increased when it is combined with Fusidic Acid. Approved, Investigational Macitentan The serum concentration of Macitentan can be increased when it is combined with Fusidic Acid. Approved Maraviroc The serum concentration of Maraviroc can be increased when it is combined with Fusidic Acid. Approved, Investigational Mebendazole The serum concentration of Mebendazole can be increased when it is combined with Fusidic Acid. Approved, Vet Approved Medical Cannabis The serum concentration of Medical Cannabis can be increased when it is combined with Fusidic Acid. Experimental Medroxyprogesterone acetate The serum concentration of Medroxyprogesterone acetate can be increased when it is combined with Fusidic Acid. Approved, Investigational Mefloquine The serum concentration of Mefloquine can be increased when it is combined with Fusidic Acid. Approved, Investigational Meloxicam The serum concentration of Meloxicam can be increased when it is combined with Fusidic Acid. Approved, Vet Approved Methadone The serum concentration of Methadone can be increased when it is combined with Fusidic Acid. Approved Methaqualone The serum concentration of Methaqualone can be increased when it is combined with Fusidic Acid. Illicit, Withdrawn Methoxsalen The serum concentration of Methoxsalen can be increased when it is combined with Fusidic Acid. Approved Methoxyflurane The serum concentration of Methoxyflurane can be increased when it is combined with Fusidic Acid. Approved, Investigational, Vet Approved Methylprednisolone The serum concentration of Methylprednisolone can be increased when it is combined with Fusidic Acid. Approved, Vet Approved Methyltestosterone The serum concentration of Methyltestosterone can be increased when it is combined with Fusidic Acid. Approved Metronidazole The serum concentration of Metronidazole can be increased when it is combined with Fusidic Acid. Approved Mevastatin The risk or severity of adverse effects can be increased when Fusidic Acid is combined with Mevastatin. Experimental Mexiletine The serum concentration of Mexiletine can be increased when it is combined with Fusidic Acid. Approved, Investigational Mianserin The serum concentration of Mianserin can be increased when it is combined with Fusidic Acid. Approved, Investigational Mibefradil The serum concentration of Mibefradil can be increased when it is combined with Fusidic Acid. Investigational, Withdrawn Miconazole The serum concentration of Miconazole can be increased when it is combined with Fusidic Acid. Approved, Investigational, Vet Approved Midazolam The serum concentration of Midazolam can be increased when it is combined with Fusidic Acid. Approved, Illicit Midostaurin The serum concentration of Midostaurin can be increased when it is combined with Fusidic Acid. Approved, Investigational Mifepristone The serum concentration of Mifepristone can be increased when it is combined with Fusidic Acid. Approved, Investigational Mirabegron The serum concentration of Mirabegron can be increased when it is combined with Fusidic Acid. Approved Mirtazapine The serum concentration of Mirtazapine can be increased when it is combined with Fusidic Acid. Approved Modafinil The serum concentration of Modafinil can be increased when it is combined with Fusidic Acid. Approved, Investigational Montelukast The serum concentration of Montelukast can be increased when it is combined with Fusidic Acid. Approved Morphine The serum concentration of Morphine can be increased when it is combined with Fusidic Acid. Approved, Investigational Mycophenolate mofetil The serum concentration of Mycophenolate mofetil can be increased when it is combined with Fusidic Acid. Approved, Investigational Nabiximols The serum concentration of Nabiximols can be increased when it is combined with Fusidic Acid. Approved Naloxegol The serum concentration of Naloxegol can be increased when it is combined with Fusidic Acid. Approved Naloxone The serum concentration of Naloxone can be increased when it is combined with Fusidic Acid. Approved, Vet Approved Nateglinide The serum concentration of Nateglinide can be increased when it is combined with Fusidic Acid. Approved, Investigational Nefazodone The serum concentration of Nefazodone can be increased when it is combined with Fusidic Acid. Approved, Withdrawn Nelfinavir The serum concentration of Nelfinavir can be increased when it is combined with Fusidic Acid. Approved Neratinib The serum concentration of Neratinib can be increased when it is combined with Fusidic Acid. Approved, Investigational Nevirapine The serum concentration of Nevirapine can be increased when it is combined with Fusidic Acid. Approved Nicardipine The serum concentration of Nicardipine can be increased when it is combined with Fusidic Acid. Approved, Investigational Nicotine The serum concentration of Nicotine can be increased when it is combined with Fusidic Acid. Approved Nifedipine The serum concentration of Nifedipine can be increased when it is combined with Fusidic Acid. Approved Nilotinib The serum concentration of Nilotinib can be increased when it is combined with Fusidic Acid. Approved, Investigational Nilvadipine The serum concentration of Nilvadipine can be increased when it is combined with Fusidic Acid. Approved, Investigational Nimodipine The serum concentration of Nimodipine can be increased when it is combined with Fusidic Acid. Approved, Investigational Nisoldipine The serum concentration of Nisoldipine can be increased when it is combined with Fusidic Acid. Approved Nitrazepam The serum concentration of Nitrazepam can be increased when it is combined with Fusidic Acid. Approved Nitrendipine The serum concentration of Nitrendipine can be increased when it is combined with Fusidic Acid. Approved, Investigational Norethisterone The serum concentration of Norethisterone can be increased when it is combined with Fusidic Acid. Approved Norgestrel The serum concentration of Norgestrel can be increased when it is combined with Fusidic Acid. Approved Nortriptyline The serum concentration of Nortriptyline can be increased when it is combined with Fusidic Acid. Approved Odanacatib The serum concentration of Odanacatib can be increased when it is combined with Fusidic Acid. Investigational Olaparib The serum concentration of Olaparib can be increased when it is combined with Fusidic Acid. Approved Olopatadine The serum concentration of Olopatadine can be increased when it is combined with Fusidic Acid. Approved Omeprazole The serum concentration of Omeprazole can be increased when it is combined with Fusidic Acid. Approved, Investigational, Vet Approved Ondansetron The serum concentration of Ondansetron can be increased when it is combined with Fusidic Acid. Approved Opium The serum concentration of Opium can be increased when it is combined with Fusidic Acid. Approved, Illicit Orphenadrine The serum concentration of Orphenadrine can be increased when it is combined with Fusidic Acid. Approved Ospemifene The serum concentration of Ospemifene can be increased when it is combined with Fusidic Acid. Approved, Investigational Oxazepam The serum concentration of Oxazepam can be increased when it is combined with Fusidic Acid. Approved Oxybutynin The serum concentration of Oxybutynin can be increased when it is combined with Fusidic Acid. Approved, Investigational Oxycodone The serum concentration of Oxycodone can be increased when it is combined with Fusidic Acid. Approved, Illicit, Investigational Oxymorphone The serum concentration of Oxymorphone can be increased when it is combined with Fusidic Acid. Approved, Investigational, Vet Approved Paclitaxel The serum concentration of Paclitaxel can be increased when it is combined with Fusidic Acid. Approved, Vet Approved Palbociclib The serum concentration of Palbociclib can be increased when it is combined with Fusidic Acid. Approved, Investigational Palonosetron The serum concentration of Palonosetron can be increased when it is combined with Fusidic Acid. Approved, Investigational Panobinostat The serum concentration of Panobinostat can be increased when it is combined with Fusidic Acid. Approved, Investigational Pantoprazole The serum concentration of Pantoprazole can be increased when it is combined with Fusidic Acid. Approved Paramethadione The serum concentration of Paramethadione can be increased when it is combined with Fusidic Acid. Approved Paramethasone The serum concentration of Paramethasone can be increased when it is combined with Fusidic Acid. Approved Parecoxib The serum concentration of Parecoxib can be increased when it is combined with Fusidic Acid. Approved Paricalcitol The serum concentration of Paricalcitol can be increased when it is combined with Fusidic Acid. Approved, Investigational Paritaprevir The serum concentration of Paritaprevir can be increased when it is combined with Fusidic Acid. Approved, Investigational Pazopanib The serum concentration of Pazopanib can be increased when it is combined with Fusidic Acid. Approved Pentamidine The serum concentration of Pentamidine can be increased when it is combined with Fusidic Acid. Approved, Investigational Perampanel The serum concentration of Perampanel can be increased when it is combined with Fusidic Acid. Approved Pergolide The serum concentration of Pergolide can be increased when it is combined with Fusidic Acid. Approved, Investigational, Vet Approved, Withdrawn Perhexiline The serum concentration of Perhexiline can be increased when it is combined with Fusidic Acid. Approved, Investigational Permethrin The serum concentration of Permethrin can be increased when it is combined with Fusidic Acid. Approved, Investigational Perospirone The serum concentration of Perospirone can be increased when it is combined with Fusidic Acid. Approved Perphenazine The serum concentration of Perphenazine can be increased when it is combined with Fusidic Acid. Approved Pethidine The serum concentration of Pethidine can be increased when it is combined with Fusidic Acid. Approved Phenacetin The serum concentration of Phenacetin can be increased when it is combined with Fusidic Acid. Withdrawn Phenindione The serum concentration of Phenindione can be increased when it is combined with Fusidic Acid. Approved, Investigational Phenoxybenzamine The serum concentration of Phenoxybenzamine can be increased when it is combined with Fusidic Acid. Approved Phenprocoumon The serum concentration of Phenprocoumon can be increased when it is combined with Fusidic Acid. Approved, Investigational Phenytoin The serum concentration of Phenytoin can be increased when it is combined with Fusidic Acid. Approved, Vet Approved Picosulfuric acid The therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Fusidic Acid. Approved Pilocarpine The serum concentration of Pilocarpine can be increased when it is combined with Fusidic Acid. Approved, Investigational Pimecrolimus The serum concentration of Pimecrolimus can be increased when it is combined with Fusidic Acid. Approved, Investigational Pimozide The serum concentration of Pimozide can be increased when it is combined with Fusidic Acid. Approved Pinacidil The serum concentration of Pinacidil can be increased when it is combined with Fusidic Acid. Approved Pioglitazone The serum concentration of Pioglitazone can be increased when it is combined with Fusidic Acid. Approved, Investigational Piperaquine The serum concentration of Piperaquine can be increased when it is combined with Fusidic Acid. Approved, Investigational Pipotiazine The serum concentration of Pipotiazine can be increased when it is combined with Fusidic Acid. Approved, Investigational Pitavastatin The risk or severity of adverse effects can be increased when Fusidic Acid is combined with Pitavastatin. Approved Pitolisant The serum concentration of Pitolisant can be increased when it is combined with Fusidic Acid. Approved, Investigational Podofilox The serum concentration of Podofilox can be increased when it is combined with Fusidic Acid. Approved Pomalidomide The serum concentration of Pomalidomide can be increased when it is combined with Fusidic Acid. Approved Ponatinib The serum concentration of Ponatinib can be increased when it is combined with Fusidic Acid. Approved, Investigational Posaconazole The serum concentration of Posaconazole can be increased when it is combined with Fusidic Acid. Approved, Investigational, Vet Approved Prasterone The serum concentration of Prasterone can be increased when it is combined with Fusidic Acid. Approved, Investigational, Nutraceutical Prasugrel The serum concentration of Prasugrel can be increased when it is combined with Fusidic Acid. Approved Pravastatin The serum concentration of Pravastatin can be increased when it is combined with Fusidic Acid. Approved Prazepam The serum concentration of Prazepam can be increased when it is combined with Fusidic Acid. Approved, Illicit Praziquantel The serum concentration of Praziquantel can be increased when it is combined with Fusidic Acid. Approved, Investigational, Vet Approved Prednisolone The serum concentration of Prednisolone can be increased when it is combined with Fusidic Acid. Approved, Vet Approved Prednisone The serum concentration of Prednisone can be increased when it is combined with Fusidic Acid. Approved, Vet Approved Primaquine The serum concentration of Primaquine can be increased when it is combined with Fusidic Acid. Approved Prochlorperazine The serum concentration of Prochlorperazine can be increased when it is combined with Fusidic Acid. Approved, Vet Approved Progesterone The serum concentration of Progesterone can be increased when it is combined with Fusidic Acid. Approved, Vet Approved Proguanil The serum concentration of Proguanil can be increased when it is combined with Fusidic Acid. Approved Promazine The serum concentration of Promazine can be increased when it is combined with Fusidic Acid. Approved, Vet Approved Propafenone The serum concentration of Propafenone can be increased when it is combined with Fusidic Acid. Approved Propiverine The serum concentration of Propiverine can be increased when it is combined with Fusidic Acid. Approved, Investigational Propofol The serum concentration of Propofol can be increased when it is combined with Fusidic Acid. Approved, Investigational, Vet Approved Propoxyphene napsylate The serum concentration of Propoxyphene napsylate can be increased when it is combined with Fusidic Acid. Approved Propranolol The serum concentration of Propranolol can be increased when it is combined with Fusidic Acid. Approved, Investigational Pyrazinamide The serum concentration of Pyrazinamide can be increased when it is combined with Fusidic Acid. Approved, Investigational Quazepam The serum concentration of Quazepam can be increased when it is combined with Fusidic Acid. Approved, Illicit Quetiapine The serum concentration of Quetiapine can be increased when it is combined with Fusidic Acid. Approved Quinacrine The serum concentration of Quinacrine can be increased when it is combined with Fusidic Acid. Approved, Investigational Quinidine The serum concentration of Quinidine can be increased when it is combined with Fusidic Acid. Approved, Investigational Quinine The serum concentration of Quinine can be increased when it is combined with Fusidic Acid. Approved Rabeprazole The serum concentration of Rabeprazole can be increased when it is combined with Fusidic Acid. Approved, Investigational Raloxifene The serum concentration of Raloxifene can be increased when it is combined with Fusidic Acid. Approved, Investigational Ramelteon The serum concentration of Ramelteon can be increased when it is combined with Fusidic Acid. Approved, Investigational Ranolazine The serum concentration of Ranolazine can be increased when it is combined with Fusidic Acid. Approved, Investigational Reboxetine The serum concentration of Reboxetine can be increased when it is combined with Fusidic Acid. Approved, Investigational Regorafenib The serum concentration of Regorafenib can be increased when it is combined with Fusidic Acid. Approved Repaglinide The serum concentration of Repaglinide can be increased when it is combined with Fusidic Acid. Approved, Investigational Retapamulin The serum concentration of Retapamulin can be increased when it is combined with Fusidic Acid. Approved Rifabutin The serum concentration of Rifabutin can be increased when it is combined with Fusidic Acid. Approved, Investigational Rifampicin The serum concentration of Rifampicin can be increased when it is combined with Fusidic Acid. Approved Rilpivirine The serum concentration of Rilpivirine can be increased when it is combined with Fusidic Acid. Approved Rimonabant The serum concentration of Rimonabant can be increased when it is combined with Fusidic Acid. Approved, Investigational Riociguat The serum concentration of Riociguat can be increased when it is combined with Fusidic Acid. Approved Risperidone The serum concentration of Risperidone can be increased when it is combined with Fusidic Acid. Approved, Investigational Ritonavir The serum concentration of Fusidic Acid can be increased when it is combined with Ritonavir. Approved, Investigational Rivaroxaban The serum concentration of Rivaroxaban can be increased when it is combined with Fusidic Acid. Approved Rofecoxib The serum concentration of Rofecoxib can be increased when it is combined with Fusidic Acid. Approved, Investigational, Withdrawn Rolapitant The serum concentration of Rolapitant can be increased when it is combined with Fusidic Acid. Approved, Investigational Romidepsin The serum concentration of Romidepsin can be increased when it is combined with Fusidic Acid. Approved, Investigational Ropinirole The serum concentration of Ropinirole can be increased when it is combined with Fusidic Acid. Approved, Investigational Ropivacaine The serum concentration of Ropivacaine can be increased when it is combined with Fusidic Acid. Approved Rosuvastatin The serum concentration of Rosuvastatin can be increased when it is combined with Fusidic Acid. Approved Rotigotine The serum concentration of Rotigotine can be increased when it is combined with Fusidic Acid. Approved Roxithromycin The serum concentration of Roxithromycin can be increased when it is combined with Fusidic Acid. Approved, Investigational, Withdrawn Rucaparib The serum concentration of Rucaparib can be increased when it is combined with Fusidic Acid. Approved, Investigational Rupatadine The serum concentration of Rupatadine can be increased when it is combined with Fusidic Acid. Approved Ruxolitinib The serum concentration of Ruxolitinib can be increased when it is combined with Fusidic Acid. Approved Safinamide The serum concentration of Safinamide can be increased when it is combined with Fusidic Acid. Approved, Investigational Salmeterol The serum concentration of Salmeterol can be increased when it is combined with Fusidic Acid. Approved Saquinavir The serum concentration of Fusidic Acid can be increased when it is combined with Saquinavir. Approved, Investigational Saxagliptin The serum concentration of Saxagliptin can be increased when it is combined with Fusidic Acid. Approved Selegiline The serum concentration of Selegiline can be increased when it is combined with Fusidic Acid. Approved, Investigational, Vet Approved Selexipag The serum concentration of Selexipag can be increased when it is combined with Fusidic Acid. Approved Seratrodast The serum concentration of Seratrodast can be increased when it is combined with Fusidic Acid. Approved Sertindole The serum concentration of Sertindole can be increased when it is combined with Fusidic Acid. Approved, Investigational, Withdrawn Sertraline The serum concentration of Sertraline can be increased when it is combined with Fusidic Acid. Approved Sevoflurane The serum concentration of Sevoflurane can be increased when it is combined with Fusidic Acid. Approved, Vet Approved Sibutramine The serum concentration of Sibutramine can be increased when it is combined with Fusidic Acid. Approved, Illicit, Investigational, Withdrawn Sildenafil The serum concentration of Sildenafil can be increased when it is combined with Fusidic Acid. Approved, Investigational Silodosin The serum concentration of Silodosin can be increased when it is combined with Fusidic Acid. Approved Simvastatin The serum concentration of Simvastatin can be increased when it is combined with Fusidic Acid. Approved Sirolimus The serum concentration of Sirolimus can be increased when it is combined with Fusidic Acid. Approved, Investigational Sitagliptin The serum concentration of Sitagliptin can be increased when it is combined with Fusidic Acid. Approved, Investigational Solifenacin The serum concentration of Solifenacin can be increased when it is combined with Fusidic Acid. Approved Sonidegib The serum concentration of Sonidegib can be increased when it is combined with Fusidic Acid. Approved, Investigational Sorafenib The serum concentration of Sorafenib can be increased when it is combined with Fusidic Acid. Approved, Investigational Spiramycin The serum concentration of Spiramycin can be increased when it is combined with Fusidic Acid. Approved Sufentanil The serum concentration of Sufentanil can be increased when it is combined with Fusidic Acid. Approved, Investigational Sulfadiazine The serum concentration of Sulfadiazine can be increased when it is combined with Fusidic Acid. Approved, Investigational, Vet Approved Sulfamethoxazole The serum concentration of Sulfamethoxazole can be increased when it is combined with Fusidic Acid. Approved Sulfinpyrazone The serum concentration of Sulfinpyrazone can be increased when it is combined with Fusidic Acid. Approved Sunitinib The serum concentration of Sunitinib can be increased when it is combined with Fusidic Acid. Approved, Investigational Synthetic Conjugated Estrogens, A The serum concentration of Synthetic Conjugated Estrogens, A can be increased when it is combined with Fusidic Acid. Approved Synthetic Conjugated Estrogens, B The serum concentration of Synthetic Conjugated Estrogens, B can be increased when it is combined with Fusidic Acid. Approved Tacrolimus The serum concentration of Tacrolimus can be increased when it is combined with Fusidic Acid. Approved, Investigational Tadalafil The serum concentration of Tadalafil can be increased when it is combined with Fusidic Acid. Approved, Investigational Tamoxifen The serum concentration of Tamoxifen can be increased when it is combined with Fusidic Acid. Approved Tamsulosin The serum concentration of Tamsulosin can be increased when it is combined with Fusidic Acid. Approved, Investigational Tasosartan The serum concentration of Tasosartan can be increased when it is combined with Fusidic Acid. Approved Taurochenodeoxycholic acid The serum concentration of Taurochenodeoxycholic acid can be increased when it is combined with Fusidic Acid. Experimental Telaprevir The serum concentration of Telaprevir can be increased when it is combined with Fusidic Acid. Approved, Withdrawn Telithromycin The serum concentration of Telithromycin can be increased when it is combined with Fusidic Acid. Approved Temazepam The serum concentration of Temazepam can be increased when it is combined with Fusidic Acid. Approved, Investigational Temsirolimus The serum concentration of Temsirolimus can be increased when it is combined with Fusidic Acid. Approved Teniposide The serum concentration of Teniposide can be increased when it is combined with Fusidic Acid. Approved Terbinafine The serum concentration of Terbinafine can be increased when it is combined with Fusidic Acid. Approved, Investigational, Vet Approved Terfenadine The serum concentration of Terfenadine can be increased when it is combined with Fusidic Acid. Approved, Withdrawn Tesmilifene The serum concentration of Tesmilifene can be increased when it is combined with Fusidic Acid. Investigational Testosterone The serum concentration of Testosterone can be increased when it is combined with Fusidic Acid. Approved, Investigational Testosterone cypionate The serum concentration of Testosterone cypionate can be increased when it is combined with Fusidic Acid. Approved Testosterone enanthate The serum concentration of Testosterone enanthate can be increased when it is combined with Fusidic Acid. Approved Testosterone propionate The serum concentration of Testosterone propionate can be increased when it is combined with Fusidic Acid. Approved, Investigational, Vet Approved, Withdrawn Testosterone undecanoate The serum concentration of Testosterone undecanoate can be increased when it is combined with Fusidic Acid. Approved, Investigational Tetracycline The serum concentration of Tetracycline can be increased when it is combined with Fusidic Acid. Approved, Vet Approved Tezacaftor The serum concentration of Tezacaftor can be increased when it is combined with Fusidic Acid. Approved, Investigational Theophylline The serum concentration of Theophylline can be increased when it is combined with Fusidic Acid. Approved Thiotepa The serum concentration of Thiotepa can be increased when it is combined with Fusidic Acid. Approved, Investigational Tiagabine The serum concentration of Tiagabine can be increased when it is combined with Fusidic Acid. Approved, Investigational Ticagrelor The serum concentration of Ticagrelor can be increased when it is combined with Fusidic Acid. Approved Ticlopidine The serum concentration of Ticlopidine can be increased when it is combined with Fusidic Acid. Approved Tinidazole The serum concentration of Tinidazole can be increased when it is combined with Fusidic Acid. Approved, Investigational Tioclomarol The serum concentration of Tioclomarol can be increased when it is combined with Fusidic Acid. Experimental Tiotropium The serum concentration of Tiotropium can be increased when it is combined with Fusidic Acid. Approved Tipranavir The serum concentration of Tipranavir can be increased when it is combined with Fusidic Acid. Approved, Investigational Tocofersolan The serum concentration of Tocofersolan can be increased when it is combined with Fusidic Acid. Approved Tocopherol The serum concentration of Tocopherol can be increased when it is combined with Fusidic Acid. Approved, Investigational Tofacitinib The serum concentration of Tofacitinib can be increased when it is combined with Fusidic Acid. Approved, Investigational Tolterodine The serum concentration of Tolterodine can be increased when it is combined with Fusidic Acid. Approved, Investigational Tolvaptan The serum concentration of Tolvaptan can be increased when it is combined with Fusidic Acid. Approved Toremifene The serum concentration of Toremifene can be increased when it is combined with Fusidic Acid. Approved, Investigational Trabectedin The serum concentration of Trabectedin can be increased when it is combined with Fusidic Acid. Approved, Investigational Tramadol The serum concentration of Tramadol can be increased when it is combined with Fusidic Acid. Approved, Investigational Trastuzumab emtansine The serum concentration of Trastuzumab emtansine can be increased when it is combined with Fusidic Acid. Approved, Investigational Trazodone The serum concentration of Trazodone can be increased when it is combined with Fusidic Acid. Approved, Investigational Tretinoin The serum concentration of Tretinoin can be increased when it is combined with Fusidic Acid. Approved, Investigational, Nutraceutical Triamcinolone The serum concentration of Triamcinolone can be increased when it is combined with Fusidic Acid. Approved, Vet Approved Triazolam The serum concentration of Triazolam can be increased when it is combined with Fusidic Acid. Approved, Investigational Trimethadione The serum concentration of Trimethadione can be increased when it is combined with Fusidic Acid. Approved Trimethoprim The serum concentration of Trimethoprim can be increased when it is combined with Fusidic Acid. Approved, Vet Approved Trimipramine The serum concentration of Trimipramine can be increased when it is combined with Fusidic Acid. Approved Troglitazone The serum concentration of Troglitazone can be increased when it is combined with Fusidic Acid. Investigational, Withdrawn Troleandomycin The serum concentration of Troleandomycin can be increased when it is combined with Fusidic Acid. Approved Udenafil The serum concentration of Udenafil can be increased when it is combined with Fusidic Acid. Approved, Investigational Ulipristal The serum concentration of Ulipristal can be increased when it is combined with Fusidic Acid. Approved Valbenazine The serum concentration of Valbenazine can be increased when it is combined with Fusidic Acid. Approved, Investigational Valdecoxib The serum concentration of Valdecoxib can be increased when it is combined with Fusidic Acid. Approved, Investigational, Withdrawn Vandetanib The serum concentration of Vandetanib can be increased when it is combined with Fusidic Acid. Approved Vanoxerine The serum concentration of Vanoxerine can be increased when it is combined with Fusidic Acid. Investigational Vardenafil The serum concentration of Vardenafil can be increased when it is combined with Fusidic Acid. Approved Velpatasvir The serum concentration of Velpatasvir can be increased when it is combined with Fusidic Acid. Approved, Investigational Vemurafenib The serum concentration of Vemurafenib can be increased when it is combined with Fusidic Acid. Approved Venetoclax The serum concentration of Venetoclax can be increased when it is combined with Fusidic Acid. Approved, Investigational Venlafaxine The serum concentration of Venlafaxine can be increased when it is combined with Fusidic Acid. Approved Verapamil The serum concentration of Verapamil can be increased when it is combined with Fusidic Acid. Approved Vicriviroc The serum concentration of Vicriviroc can be increased when it is combined with Fusidic Acid. Investigational Vilanterol The serum concentration of Vilanterol can be increased when it is combined with Fusidic Acid. Approved Vilazodone The serum concentration of Vilazodone can be increased when it is combined with Fusidic Acid. Approved Vinblastine The serum concentration of Vinblastine can be increased when it is combined with Fusidic Acid. Approved Vincristine The serum concentration of Vincristine can be increased when it is combined with Fusidic Acid. Approved, Investigational Vindesine The serum concentration of Vindesine can be increased when it is combined with Fusidic Acid. Approved, Investigational Vinflunine The serum concentration of Vinflunine can be increased when it is combined with Fusidic Acid. Approved, Investigational Vinorelbine The serum concentration of Vinorelbine can be increased when it is combined with Fusidic Acid. Approved, Investigational Vismodegib The serum concentration of Vismodegib can be increased when it is combined with Fusidic Acid. Approved, Investigational Voriconazole The serum concentration of Voriconazole can be increased when it is combined with Fusidic Acid. Approved, Investigational Vortioxetine The serum concentration of Vortioxetine can be increased when it is combined with Fusidic Acid. Approved, Investigational Voxilaprevir The serum concentration of Voxilaprevir can be increased when it is combined with Fusidic Acid. Approved, Investigational Warfarin The serum concentration of Warfarin can be increased when it is combined with Fusidic Acid. Approved Yohimbine The serum concentration of Yohimbine can be increased when it is combined with Fusidic Acid. Approved, Investigational, Vet Approved Zafirlukast The serum concentration of Zafirlukast can be increased when it is combined with Fusidic Acid. Approved, Investigational Zalcitabine The serum concentration of Zalcitabine can be increased when it is combined with Fusidic Acid. Approved, Investigational Zaleplon The serum concentration of Zaleplon can be increased when it is combined with Fusidic Acid. Approved, Illicit, Investigational Zidovudine The serum concentration of Zidovudine can be increased when it is combined with Fusidic Acid. Approved Zileuton The serum concentration of Zileuton can be increased when it is combined with Fusidic Acid. Approved, Investigational, Withdrawn Ziprasidone The serum concentration of Ziprasidone can be increased when it is combined with Fusidic Acid. Approved Zolpidem The serum concentration of Zolpidem can be increased when it is combined with Fusidic Acid. Approved Zomepirac The serum concentration of Zomepirac can be increased when it is combined with Fusidic Acid. Withdrawn Zonisamide The serum concentration of Zonisamide can be increased when it is combined with Fusidic Acid. Approved, Investigational Zopiclone The serum concentration of Zopiclone can be increased when it is combined with Fusidic Acid. Approved Zotepine The serum concentration of Zotepine can be increased when it is combined with Fusidic Acid. Approved, Investigational, Withdrawn - Food Interactions
- Take with food to reduce irritation.
References
- Synthesis Reference
Vanangamudi Subramaniam Sulur, Madhavan Srinivasan, Neelakandan Narayanan Chulliel, Haridas Sankar, Selvaraj Balkrishnan, " PROCESS TO MAKE FUSIDIC ACID CREAM." U.S. Patent US20110301138, issued December 08, 2011.
US20110301138- General References
- Not Available
- External Links
- Human Metabolome Database
- HMDB0015570
- KEGG Drug
- D04281
- KEGG Compound
- C06694
- PubChem Compound
- 3000226
- PubChem Substance
- 46505364
- ChemSpider
- 2271900
- BindingDB
- 58924
- ChEBI
- 29013
- ChEMBL
- CHEMBL374975
- Therapeutic Targets Database
- DAP001008
- PharmGKB
- PA164749648
- HET
- FUA
- Wikipedia
- Fusidic_acid
- ATC Codes
- J01XC01 — Fusidic acid
- J01XC — Steroid antibacterials
- J01X — OTHER ANTIBACTERIALS
- J01 — ANTIBACTERIALS FOR SYSTEMIC USE
- J — ANTIINFECTIVES FOR SYSTEMIC USE
- D06AX — Other antibiotics for topical use
- D06A — ANTIBIOTICS FOR TOPICAL USE
- D06 — ANTIBIOTICS AND CHEMOTHERAPEUTICS FOR DERMATOLOGICAL USE
- D — DERMATOLOGICALS
- D09AA — Medicated dressings with antiinfectives
- D09A — MEDICATED DRESSINGS
- D09 — MEDICATED DRESSINGS
- D — DERMATOLOGICALS
- AHFS Codes
- 52:04.04 — Antibacterials
- 84:04.04 — Antibiotics
- 08:12.28.92 — Other Miscellaneous Antibacterial Agents*
- PDB Entries
- 1q23 / 1qca / 2vuf / 4v5f / 4v5m / 4v5n / 4v7b / 4v8u / 4v9l / 4v9m … show 2 more
Clinical Trials
- Clinical Trials
Phase Status Purpose Conditions Count 2 Completed Treatment Skin Diseases, Bacterial 1 2 Terminated Treatment Infected Spacers / Prosthetic Joint Infections of Hip / Prosthetic Joint Infections of Knee 1 2, 3 Active Not Recruiting Treatment Refractory Bone or Joint Infections 1 3 Completed Treatment Lung Cancer Non-Small Cell Cancer (NSCLC) 1 3 Not Yet Recruiting Treatment Infected Atopic Dermatitis/Eczema 1 3 Unknown Status Prevention Hypertrophic Scars / Keloid Scars 1 4 Enrolling by Invitation Treatment Inflammation of the Eyelids 1 4 Terminated Treatment Impetigo 1 Not Available Completed Not Available Impetigo 1 Not Available Not Yet Recruiting Treatment Prosthetic Joint Infection 1 Not Available Recruiting Prevention Motility Disorders / Staphylococcus Aureus 1
Pharmacoeconomics
- Manufacturers
- Not Available
- Packagers
- Not Available
- Dosage forms
Form Route Strength Cream Topical 2 % Tablet Oral 250 mg Cream Topical Dressing Topical 2 % Kit Intravenous Suspension Oral 246 mg Ointment Topical 2 % Solution / drops Ophthalmic 1 % - Prices
Unit description Cost Unit Fucidin 2 % Cream 0.66USD g Fucidin 2 % Ointment 0.66USD g DrugBank does not sell nor buy drugs. Pricing information is supplied for informational purposes only.- Patents
- Not Available
Properties
- State
- Solid
- Experimental Properties
Property Value Source melting point (°C) 192.5 °C PhysProp pKa 5.35 MERCK INDEX (1996) - Predicted Properties
Property Value Source Water Solubility 0.00521 mg/mL ALOGPS logP 4.97 ALOGPS logP 4.42 ChemAxon logS -5 ALOGPS pKa (Strongest Acidic) 4.66 ChemAxon pKa (Strongest Basic) -0.2 ChemAxon Physiological Charge -1 ChemAxon Hydrogen Acceptor Count 5 ChemAxon Hydrogen Donor Count 3 ChemAxon Polar Surface Area 104.06 Å2 ChemAxon Rotatable Bond Count 6 ChemAxon Refractivity 144.12 m3·mol-1 ChemAxon Polarizability 59.77 Å3 ChemAxon Number of Rings 4 ChemAxon Bioavailability 1 ChemAxon Rule of Five No ChemAxon Ghose Filter No ChemAxon Veber's Rule No ChemAxon MDDR-like Rule Yes ChemAxon - Predicted ADMET features
Property Value Probability Human Intestinal Absorption + 0.9691 Blood Brain Barrier + 0.7909 Caco-2 permeable - 0.6089 P-glycoprotein substrate Substrate 0.8165 P-glycoprotein inhibitor I Non-inhibitor 0.6004 P-glycoprotein inhibitor II Inhibitor 0.7848 Renal organic cation transporter Non-inhibitor 0.8424 CYP450 2C9 substrate Non-substrate 0.8218 CYP450 2D6 substrate Non-substrate 0.9349 CYP450 3A4 substrate Substrate 0.798 CYP450 1A2 substrate Non-inhibitor 0.9337 CYP450 2C9 inhibitor Non-inhibitor 0.8834 CYP450 2D6 inhibitor Non-inhibitor 0.9544 CYP450 2C19 inhibitor Non-inhibitor 0.9347 CYP450 3A4 inhibitor Non-inhibitor 0.76 CYP450 inhibitory promiscuity Low CYP Inhibitory Promiscuity 0.819 Ames test Non AMES toxic 0.8305 Carcinogenicity Non-carcinogens 0.9508 Biodegradation Not ready biodegradable 0.9753 Rat acute toxicity 3.5929 LD50, mol/kg Not applicable hERG inhibition (predictor I) Weak inhibitor 0.9403 hERG inhibition (predictor II) Non-inhibitor 0.7564
Spectra
- Mass Spec (NIST)
- Not Available
- Spectra
Spectrum Spectrum Type Splash Key Predicted GC-MS Spectrum - GC-MS Predicted GC-MS Not Available Predicted MS/MS Spectrum - 10V, Positive (Annotated) Predicted LC-MS/MS Not Available Predicted MS/MS Spectrum - 20V, Positive (Annotated) Predicted LC-MS/MS Not Available Predicted MS/MS Spectrum - 40V, Positive (Annotated) Predicted LC-MS/MS Not Available Predicted MS/MS Spectrum - 10V, Negative (Annotated) Predicted LC-MS/MS Not Available Predicted MS/MS Spectrum - 20V, Negative (Annotated) Predicted LC-MS/MS Not Available Predicted MS/MS Spectrum - 40V, Negative (Annotated) Predicted LC-MS/MS Not Available MS/MS Spectrum - Linear Ion Trap , negative LC-MS/MS splash10-05fr-0002900000-512150f35d55c73b9e09 MS/MS Spectrum - Linear Ion Trap , positive LC-MS/MS splash10-004i-0000900000-eecd35dcbd3fede944c2 MS/MS Spectrum - Linear Ion Trap , positive LC-MS/MS splash10-0002-0000900000-4a266f99ada066a14539
Taxonomy
- Description
- This compound belongs to the class of organic compounds known as steroid esters. These are compounds containing a steroid moiety which bears a carboxylic acid ester group.
- Kingdom
- Organic compounds
- Super Class
- Lipids and lipid-like molecules
- Class
- Steroids and steroid derivatives
- Sub Class
- Steroid esters
- Direct Parent
- Steroid esters
- Alternative Parents
- 3-alpha-hydroxysteroids / 11-alpha-hydroxysteroids / Medium-chain fatty acids / Methyl-branched fatty acids / Hydroxy fatty acids / Unsaturated fatty acids / Dicarboxylic acids and derivatives / Secondary alcohols / Cyclic alcohols and derivatives / Carboxylic acid esters show 4 more
- Substituents
- Steroid ester / 3-hydroxysteroid / 3-alpha-hydroxysteroid / 11-hydroxysteroid / 11-alpha-hydroxysteroid / Hydroxysteroid / Medium-chain fatty acid / Branched fatty acid / Methyl-branched fatty acid / Hydroxy fatty acid show 16 more
- Molecular Framework
- Aliphatic homopolycyclic compounds
- External Descriptors
- 3alpha-hydroxy steroid, alpha,beta-unsaturated monocarboxylic acid, sterol ester, steroid acid, 11alpha-hydroxy steroid, steroid antibiotic (CHEBI:29013) / Prostostane and fusidane triterpenoids (LMPR0106040001)
Targets
- Kind
- Protein
- Organism
- Thermus thermophilus
- Pharmacological action
- Yes
- Actions
- Inhibitor
- General Function
- Translation elongation factor activity
- Specific Function
- Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) ...
- Gene Name
- fusA
- Uniprot ID
- P13551
- Uniprot Name
- Elongation factor G
- Molecular Weight
- 76878.69 Da
References
- Lannergard J, Norstrom T, Hughes D: Genetic determinants of resistance to fusidic acid among clinical bacteremia isolates of Staphylococcus aureus. Antimicrob Agents Chemother. 2009 May;53(5):2059-65. doi: 10.1128/AAC.00871-08. Epub 2009 Mar 16. [PubMed:19289529]
- Chen Y, Koripella RK, Sanyal S, Selmer M: Staphylococcus aureus elongation factor G--structure and analysis of a target for fusidic acid. FEBS J. 2010 Sep;277(18):3789-803. doi: 10.1111/j.1742-4658.2010.07780.x. Epub 2010 Aug 13. [PubMed:20718859]
- Gao YG, Selmer M, Dunham CM, Weixlbaumer A, Kelley AC, Ramakrishnan V: The structure of the ribosome with elongation factor G trapped in the posttranslocational state. Science. 2009 Oct 30;326(5953):694-9. doi: 10.1126/science.1179709. [PubMed:19833919]
- Kind
- Protein
- Organism
- Salmonella typhi
- Pharmacological action
- Unknown
- Actions
- Inhibitor
- General Function
- Chloramphenicol o-acetyltransferase activity
- Specific Function
- This enzyme is an effector of chloramphenicol resistance in bacteria.
- Gene Name
- cat
- Uniprot ID
- P62580
- Uniprot Name
- Chloramphenicol acetyltransferase
- Molecular Weight
- 25663.08 Da
References
- Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284]
- Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423]
- Murray IA, Cann PA, Day PJ, Derrick JP, Sutcliffe MJ, Shaw WV, Leslie AG: Steroid recognition by chloramphenicol acetyltransferase: engineering and structural analysis of a high affinity fusidic acid binding site. J Mol Biol. 1995 Dec 15;254(5):993-1005. [PubMed:7500366]
- Bennett AD, Shaw WV: Resistance to fusidic acid in Escherichia coli mediated by the type I variant of chloramphenicol acetyltransferase. A plasmid-encoded mechanism involving antibiotic binding. Biochem J. 1983 Oct 1;215(1):29-38. [PubMed:6354181]
- Day PJ, Murray IA, Shaw WV: Properties of hybrid active sites in oligomeric proteins: kinetic and ligand binding studies with chloramphenicol acetyltransferase trimers. Biochemistry. 1995 May 16;34(19):6416-22. [PubMed:7756272]
- Kind
- Protein
- Organism
- Escherichia coli
- Pharmacological action
- Unknown
- Actions
- Inhibitor
- General Function
- Chloramphenicol o-acetyltransferase activity
- Specific Function
- This enzyme is an effector of chloramphenicol resistance in bacteria.
- Gene Name
- cat3
- Uniprot ID
- P00484
- Uniprot Name
- Chloramphenicol acetyltransferase 3
- Molecular Weight
- 24993.32 Da
References
- Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284]
- Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423]
- Murray IA, Cann PA, Day PJ, Derrick JP, Sutcliffe MJ, Shaw WV, Leslie AG: Steroid recognition by chloramphenicol acetyltransferase: engineering and structural analysis of a high affinity fusidic acid binding site. J Mol Biol. 1995 Dec 15;254(5):993-1005. [PubMed:7500366]
- Bennett AD, Shaw WV: Resistance to fusidic acid in Escherichia coli mediated by the type I variant of chloramphenicol acetyltransferase. A plasmid-encoded mechanism involving antibiotic binding. Biochem J. 1983 Oct 1;215(1):29-38. [PubMed:6354181]
- Day PJ, Murray IA, Shaw WV: Properties of hybrid active sites in oligomeric proteins: kinetic and ligand binding studies with chloramphenicol acetyltransferase trimers. Biochemistry. 1995 May 16;34(19):6416-22. [PubMed:7756272]
Transporters
- Kind
- Protein
- Organism
- Human
- Pharmacological action
- Unknown
- Actions
- Inhibitor
- General Function
- Transporter activity
- Specific Function
- Involved in the ATP-dependent secretion of bile salts into the canaliculus of hepatocytes.
- Gene Name
- ABCB11
- Uniprot ID
- O95342
- Uniprot Name
- Bile salt export pump
- Molecular Weight
- 146405.83 Da
References
- Bode KA, Donner MG, Leier I, Keppler D: Inhibition of transport across the hepatocyte canalicular membrane by the antibiotic fusidate. Biochem Pharmacol. 2002 Jul 1;64(1):151-8. [PubMed:12106615]
- Kind
- Protein
- Organism
- Human
- Pharmacological action
- Unknown
- Actions
- Inhibitor
- General Function
- Organic anion transmembrane transporter activity
- Specific Function
- Mediates hepatobiliary excretion of numerous organic anions. May function as a cellular cisplatin transporter.
- Gene Name
- ABCC2
- Uniprot ID
- Q92887
- Uniprot Name
- Canalicular multispecific organic anion transporter 1
- Molecular Weight
- 174205.64 Da
References
- Bode KA, Donner MG, Leier I, Keppler D: Inhibition of transport across the hepatocyte canalicular membrane by the antibiotic fusidate. Biochem Pharmacol. 2002 Jul 1;64(1):151-8. [PubMed:12106615]
Drug created on June 13, 2005 07:24 / Updated on April 23, 2018 23:09