Fusidic Acid

Identification

Name

Fusidic Acid

Accession Number

DB02703  (EXPT01507)

Type

Small Molecule

Groups

Approved, Investigational

Description

An antibiotic isolated from the fermentation broth of Fusidium coccineum. (From Merck Index, 11th ed) It acts by inhibiting translocation during protein synthesis.

Structure

3D

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MOLSDF3D-SDFPDBSMILESInChI

Similar Structures

Structure for DB02703 (Fusidic Acid)

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Synonyms

• Fucidate
• Fucidin acid
• Fusidate
• Fusidic acid
• Fusidine
• Ramycin

External IDs

NSC-56192 / SQ 16,603 / SQ-16603

Product Ingredients

Ingredient	UNII	CAS	InChI Key
Fucidate Sodium	J7P3696BCQ	751-94-0	IECPWNUMDGFDKC-MZJAQBGESA-N

Prescription Products

Name	Dosage	Strength	Route	Labeller	Marketing Start	Marketing End
Fucidin Cream 2%	Cream	2 %	Topical	Leo Pharma	1984-12-31	Not applicable
Fucidin Film Coated Tab 250mg	Tablet	250 mg	Oral	Leo Pharma	1991-12-31	2009-06-05
Fucidin Intertulle 2%	Dressing	2 %	Topical	Leo Pharma	1984-12-31	2004-07-23
Fucidin Leo Sus 246mg/5ml	Suspension	246 mg	Oral	Leo Pharma	1980-12-31	2004-07-23
Fucidin Ointment 2%	Ointment	2 %	Topical	Leo Pharma	1984-12-31	Not applicable
Fucithalmic	Solution / drops	1 %	Ophthalmic	Amdipharm Limited	2001-08-29	Not applicable
Fucithalmic	Solution / drops	1 %	Ophthalmic	Amdipharm Limited	2001-08-07	2017-07-17

Mixture Products

Name	Ingredients	Dosage	Route	Labeller	Marketing Start	Marketing End
Fucibet	Fusidic Acid (2 %) + Betamethasone (0.1 %)	Cream	Topical	Leo Pharma	Not applicable	Not applicable
Fucidin H	Fusidic Acid (2 %) + Hydrocortisone acetate (1 %)	Cream	Topical	Leo Pharma	1998-11-11	Not applicable
Fucidin Leo Injection Kit	Fucidate Sodium (500 mg) + Sodium phosphate, dibasic (10 ml)	Kit	Intravenous	Leo Pharma	1984-12-31	2004-08-01

International/Other Brands

Fucidin / Fucidine / Fudic / Taksta

Categories

• Anti-Bacterial Agents
• Anti-Infective Agents
• Antibacterials for Systemic Use
• Antibiotics for Topical Use
• Antiinfectives for Systemic Use
• BSEP/ABCB11 Inhibitors
• Cholestadienes
• Cholestadienols
• Cholestanes
• Cholestenes
• Dermatologicals
• Enzyme Inhibitors
• Lipids
• Medicated Dressings
• Medicated Dressings With Antiinfectives
• Membrane Lipids
• Ophthalmologicals
• Other Miscellaneous Antibacterial Agents
• Protein Synthesis Inhibitors
• Sensory Organs
• Steroid Antibacterials
• Steroids
• Sterols

UNII

59XE10C19C

CAS number

6990-06-3

Weight

Average: 516.7092
Monoisotopic: 516.345089268

Chemical Formula

C₃₁H₄₈O₆

InChI Key

IECPWNUMDGFDKC-MZJAQBGESA-N

InChI

InChI=1S/C31H48O6/c1-17(2)9-8-10-20(28(35)36)26-22-15-24(34)27-29(5)13-12-23(33)18(3)21(29)11-14-30(27,6)31(22,7)16-25(26)37-19(4)32/h9,18,21-25,27,33-34H,8,10-16H2,1-7H3,(H,35,36)/b26-20-/t18-,21-,22-,23+,24+,25-,27-,29-,30-,31-/m0/s1

IUPAC Name

2-[(1S,2S,5R,6S,7S,10S,11S,13S,14Z,15R,17R)-13-(acetyloxy)-5,17-dihydroxy-2,6,10,11-tetramethyltetracyclo[8.7.0.0²,⁷.0¹¹,¹⁵]heptadecan-14-ylidene]-6-methylhept-5-enoic acid

SMILES

O[C@@H]1CC[C@@]2(C)[C@@]([H])(CC[C@@]3(C)[C@@]2([H])[C@H](O)C[C@@]2([H])\C([C@@H](OC(=O)C)C[C@]32C)=C(/CCC=C(C)C)C(O)=O)[C@@H]1C

Pharmacology

Indication

For the treatment of bacterial infections.

Associated Conditions

• Conjunctivitis, Bacterial
• Mild Atopic dermatitis
• Mild Dermatitis caused by Staphylococcus aureusis
• Moderate Atopic dermatitis
• Moderate Dermatitis caused by Staphylococcus aureusis

Pharmacodynamics

Fusidic acid is a bacteriostatic antibiotic that is often used topically in creams and eyedrops, but may also be given systemically as tablets or injections.

Mechanism of action

Fusidic acid works by interfering with bacterial protein synthesis, specifically by preventing the translocation of the elongation factor G (EF-G) from the ribosome. It also can inhibit chloramphenicol acetyltransferase enzymes.

Target	Actions	Organism
AElongation factor G	inhibitor	Thermus thermophilus
UChloramphenicol acetyltransferase	inhibitor	Salmonella typhi
UChloramphenicol acetyltransferase 3	inhibitor	Escherichia coli

Absorption

Sodium fusidic acid tablets have a 91% oral bioavailability. Absorption of the film-coated tablets is complete when compared to a solution, however oral absorption is variable. Oral fusidic acid hemihydrate (suspension) achieved a 22.5% bioavailability in pediatric patients following a 20 milligram/kilogram dose.

Volume of distribution

Not Available

Protein binding

97 to 99%

Metabolism

Metabolites include dicarboxylic ester/acid, 3-keto fusidic acid, hydroxy fusidic acid, glucuronide fusidic acid and a glycol metabolite.

• Fusidic Acid
  Dicarboxylic acid
• Fusidic Acid
  3-keto fusidic acid
• Fusidic Acid
  dicarboxylic ester
• Fusidic Acid
  Glucuronide fusidic acid
• Fusidic Acid
  Hydroxy fusidic acid

Route of elimination

Not Available

Half life

Approximately 5 to 6 hours in adults.

Clearance

Not Available

Toxicity

Not Available

Affected organisms

• Enteric bacteria and other eubacteria

Pathways

Not Available

Pharmacogenomic Effects/ADRs

Not Available

Interactions

Drug Interactions

Drug	Interaction	Drug group
Abemaciclib	The serum concentration of Abemaciclib can be increased when it is combined with Fusidic Acid.	Approved, Investigational
Abiraterone	The serum concentration of Abiraterone can be increased when it is combined with Fusidic Acid.	Approved
Acenocoumarol	The serum concentration of Acenocoumarol can be increased when it is combined with Fusidic Acid.	Approved, Investigational
Acetaminophen	The serum concentration of Acetaminophen can be increased when it is combined with Fusidic Acid.	Approved
Adinazolam	The serum concentration of Adinazolam can be increased when it is combined with Fusidic Acid.	Approved
Agmatine	The serum concentration of Agmatine can be increased when it is combined with Fusidic Acid.	Experimental, Investigational
Albendazole	The serum concentration of Albendazole can be increased when it is combined with Fusidic Acid.	Approved, Vet Approved
Alclometasone	The serum concentration of Alclometasone can be increased when it is combined with Fusidic Acid.	Approved
Alfentanil	The serum concentration of Alfentanil can be increased when it is combined with Fusidic Acid.	Approved, Illicit
Alfuzosin	The serum concentration of Alfuzosin can be increased when it is combined with Fusidic Acid.	Approved, Investigational
Aliskiren	The serum concentration of Aliskiren can be increased when it is combined with Fusidic Acid.	Approved, Investigational
Allylestrenol	The serum concentration of Allylestrenol can be increased when it is combined with Fusidic Acid.	Approved
Almotriptan	The serum concentration of Almotriptan can be increased when it is combined with Fusidic Acid.	Approved, Investigational
Alogliptin	The serum concentration of Alogliptin can be increased when it is combined with Fusidic Acid.	Approved
Alosetron	The serum concentration of Alosetron can be increased when it is combined with Fusidic Acid.	Approved, Withdrawn
alpha-Tocopherol acetate	The serum concentration of alpha-Tocopherol acetate can be increased when it is combined with Fusidic Acid.	Approved
Alprazolam	The serum concentration of Alprazolam can be increased when it is combined with Fusidic Acid.	Approved, Illicit, Investigational
Ambrisentan	The serum concentration of Ambrisentan can be increased when it is combined with Fusidic Acid.	Approved, Investigational
Ambroxol	The serum concentration of Ambroxol can be increased when it is combined with Fusidic Acid.	Approved, Investigational
Aminophenazone	The serum concentration of Aminophenazone can be increased when it is combined with Fusidic Acid.	Approved, Withdrawn
Aminophylline	The serum concentration of Aminophylline can be increased when it is combined with Fusidic Acid.	Approved
Amiodarone	The serum concentration of Amiodarone can be increased when it is combined with Fusidic Acid.	Approved, Investigational
Amitriptyline	The serum concentration of Amitriptyline can be increased when it is combined with Fusidic Acid.	Approved
Amlodipine	The serum concentration of Amlodipine can be increased when it is combined with Fusidic Acid.	Approved
Amprenavir	The serum concentration of Amprenavir can be increased when it is combined with Fusidic Acid.	Approved, Investigational
Antipyrine	The serum concentration of Antipyrine can be increased when it is combined with Fusidic Acid.	Approved, Investigational
Apalutamide	The serum concentration of Apalutamide can be increased when it is combined with Fusidic Acid.	Approved, Investigational
Apixaban	The serum concentration of Apixaban can be increased when it is combined with Fusidic Acid.	Approved
Apremilast	The serum concentration of Apremilast can be increased when it is combined with Fusidic Acid.	Approved, Investigational
Aprepitant	The serum concentration of Aprepitant can be increased when it is combined with Fusidic Acid.	Approved, Investigational
Aranidipine	The serum concentration of Aranidipine can be increased when it is combined with Fusidic Acid.	Approved, Investigational
Argatroban	The serum concentration of Argatroban can be increased when it is combined with Fusidic Acid.	Approved, Investigational
Aripiprazole	The serum concentration of Aripiprazole can be increased when it is combined with Fusidic Acid.	Approved, Investigational
Artemether	The serum concentration of Artemether can be increased when it is combined with Fusidic Acid.	Approved
Asenapine	The serum concentration of Asenapine can be increased when it is combined with Fusidic Acid.	Approved
Astemizole	The serum concentration of Astemizole can be increased when it is combined with Fusidic Acid.	Approved, Withdrawn
Asunaprevir	The serum concentration of Asunaprevir can be increased when it is combined with Fusidic Acid.	Approved, Investigational, Withdrawn
Atazanavir	The serum concentration of Atazanavir can be increased when it is combined with Fusidic Acid.	Approved, Investigational
Atorvastatin	The serum concentration of Atorvastatin can be increased when it is combined with Fusidic Acid.	Approved
Avanafil	The serum concentration of Avanafil can be increased when it is combined with Fusidic Acid.	Approved
Avatrombopag	The serum concentration of Avatrombopag can be increased when it is combined with Fusidic Acid.	Approved, Investigational
Axitinib	The serum concentration of Axitinib can be increased when it is combined with Fusidic Acid.	Approved, Investigational
Azelastine	The serum concentration of Azelastine can be increased when it is combined with Fusidic Acid.	Approved
Azelnidipine	The serum concentration of Azelnidipine can be increased when it is combined with Fusidic Acid.	Approved, Investigational
Azithromycin	The serum concentration of Azithromycin can be increased when it is combined with Fusidic Acid.	Approved
Banoxantrone	The serum concentration of Banoxantrone can be increased when it is combined with Fusidic Acid.	Investigational
Baricitinib	The serum concentration of Baricitinib can be increased when it is combined with Fusidic Acid.	Approved, Investigational
Barnidipine	The serum concentration of Barnidipine can be increased when it is combined with Fusidic Acid.	Approved
Beclomethasone dipropionate	The serum concentration of Beclomethasone dipropionate can be increased when it is combined with Fusidic Acid.	Approved, Investigational
Bedaquiline	The serum concentration of Bedaquiline can be increased when it is combined with Fusidic Acid.	Approved
Bencyclane	The serum concentration of Bencyclane can be increased when it is combined with Fusidic Acid.	Experimental
Benidipine	The serum concentration of Benidipine can be increased when it is combined with Fusidic Acid.	Approved, Investigational
Benzphetamine	The serum concentration of Benzphetamine can be increased when it is combined with Fusidic Acid.	Approved, Illicit
Benzyl alcohol	The serum concentration of Benzyl alcohol can be increased when it is combined with Fusidic Acid.	Approved
Bepridil	The serum concentration of Bepridil can be increased when it is combined with Fusidic Acid.	Approved, Withdrawn
Bexarotene	The serum concentration of Bexarotene can be increased when it is combined with Fusidic Acid.	Approved, Investigational
Bezafibrate	The serum concentration of Bezafibrate can be increased when it is combined with Fusidic Acid.	Approved, Investigational
Bicalutamide	The serum concentration of Bicalutamide can be increased when it is combined with Fusidic Acid.	Approved
Bictegravir	The serum concentration of Bictegravir can be increased when it is combined with Fusidic Acid.	Approved, Investigational
Bioallethrin	The serum concentration of Bioallethrin can be increased when it is combined with Fusidic Acid.	Approved, Experimental
Bisoprolol	The serum concentration of Bisoprolol can be increased when it is combined with Fusidic Acid.	Approved
Blonanserin	The serum concentration of Blonanserin can be increased when it is combined with Fusidic Acid.	Approved, Investigational
Boceprevir	The serum concentration of Boceprevir can be increased when it is combined with Fusidic Acid.	Approved, Withdrawn
Bortezomib	The serum concentration of Bortezomib can be increased when it is combined with Fusidic Acid.	Approved, Investigational
Bosentan	The serum concentration of Bosentan can be increased when it is combined with Fusidic Acid.	Approved, Investigational
Bosutinib	The serum concentration of Bosutinib can be increased when it is combined with Fusidic Acid.	Approved
Brentuximab vedotin	The serum concentration of Brentuximab vedotin can be increased when it is combined with Fusidic Acid.	Approved, Investigational
Brexpiprazole	The serum concentration of Brexpiprazole can be increased when it is combined with Fusidic Acid.	Approved, Investigational
Brigatinib	The serum concentration of Brigatinib can be increased when it is combined with Fusidic Acid.	Approved, Investigational
Brinzolamide	The serum concentration of Brinzolamide can be increased when it is combined with Fusidic Acid.	Approved
Brivaracetam	The serum concentration of Brivaracetam can be increased when it is combined with Fusidic Acid.	Approved, Investigational
Bromazepam	The serum concentration of Bromazepam can be increased when it is combined with Fusidic Acid.	Approved, Illicit, Investigational
Bromocriptine	The serum concentration of Bromocriptine can be increased when it is combined with Fusidic Acid.	Approved, Investigational
Brompheniramine	The serum concentration of Brompheniramine can be increased when it is combined with Fusidic Acid.	Approved
Budesonide	The serum concentration of Budesonide can be increased when it is combined with Fusidic Acid.	Approved
Bupivacaine	The serum concentration of Bupivacaine can be increased when it is combined with Fusidic Acid.	Approved, Investigational
Buprenorphine	The serum concentration of Buprenorphine can be increased when it is combined with Fusidic Acid.	Approved, Illicit, Investigational, Vet Approved
Bupropion	The serum concentration of Bupropion can be increased when it is combined with Fusidic Acid.	Approved
Buspirone	The serum concentration of Buspirone can be increased when it is combined with Fusidic Acid.	Approved, Investigational
Busulfan	The serum concentration of Busulfan can be increased when it is combined with Fusidic Acid.	Approved, Investigational
Cabazitaxel	The serum concentration of Cabazitaxel can be increased when it is combined with Fusidic Acid.	Approved
Cabergoline	The serum concentration of Cabergoline can be increased when it is combined with Fusidic Acid.	Approved
Cabozantinib	The serum concentration of Cabozantinib can be increased when it is combined with Fusidic Acid.	Approved, Investigational
Caffeine	The serum concentration of Caffeine can be increased when it is combined with Fusidic Acid.	Approved
Calcitriol	The serum concentration of Calcitriol can be increased when it is combined with Fusidic Acid.	Approved, Nutraceutical
Canagliflozin	The serum concentration of Canagliflozin can be increased when it is combined with Fusidic Acid.	Approved
Cannabidiol	The serum concentration of Cannabidiol can be increased when it is combined with Fusidic Acid.	Approved, Investigational
Carbamazepine	The serum concentration of Carbamazepine can be increased when it is combined with Fusidic Acid.	Approved, Investigational
Carbinoxamine	The serum concentration of Carbinoxamine can be increased when it is combined with Fusidic Acid.	Approved
Carboxyamidotriazole	The serum concentration of Carboxyamidotriazole can be increased when it is combined with Fusidic Acid.	Investigational
Cariprazine	The serum concentration of Cariprazine can be increased when it is combined with Fusidic Acid.	Approved, Investigational
Caroverine	The serum concentration of Caroverine can be increased when it is combined with Fusidic Acid.	Experimental
Carvedilol	The serum concentration of Carvedilol can be increased when it is combined with Fusidic Acid.	Approved, Investigational
Celecoxib	The serum concentration of Celecoxib can be increased when it is combined with Fusidic Acid.	Approved, Investigational
Celiprolol	The serum concentration of Celiprolol can be increased when it is combined with Fusidic Acid.	Approved, Investigational
Cephalexin	The serum concentration of Cephalexin can be increased when it is combined with Fusidic Acid.	Approved, Investigational, Vet Approved
Cerivastatin	The serum concentration of Cerivastatin can be increased when it is combined with Fusidic Acid.	Approved, Withdrawn
Cevimeline	The serum concentration of Cevimeline can be increased when it is combined with Fusidic Acid.	Approved
Chenodeoxycholic acid	The serum concentration of Chenodeoxycholic acid can be increased when it is combined with Fusidic Acid.	Approved
Chlordiazepoxide	The serum concentration of Chlordiazepoxide can be increased when it is combined with Fusidic Acid.	Approved, Illicit, Investigational
Chloroquine	The serum concentration of Chloroquine can be increased when it is combined with Fusidic Acid.	Approved, Investigational, Vet Approved
Chlorphenamine	The serum concentration of Chlorphenamine can be increased when it is combined with Fusidic Acid.	Approved
Chlorpromazine	The serum concentration of Chlorpromazine can be increased when it is combined with Fusidic Acid.	Approved, Investigational, Vet Approved
Chlorzoxazone	The serum concentration of Chlorzoxazone can be increased when it is combined with Fusidic Acid.	Approved
Cholecalciferol	The serum concentration of Cholecalciferol can be increased when it is combined with Fusidic Acid.	Approved, Nutraceutical
Cholic Acid	Fusidic Acid may decrease the excretion rate of Cholic Acid which could result in a higher serum level.	Approved
Ciclesonide	The serum concentration of Ciclesonide can be increased when it is combined with Fusidic Acid.	Approved, Investigational
Cilnidipine	The serum concentration of Cilnidipine can be increased when it is combined with Fusidic Acid.	Approved, Investigational
Cilostazol	The serum concentration of Cilostazol can be increased when it is combined with Fusidic Acid.	Approved, Investigational
Cinacalcet	The serum concentration of Cinacalcet can be increased when it is combined with Fusidic Acid.	Approved
Cinnarizine	The serum concentration of Cinnarizine can be increased when it is combined with Fusidic Acid.	Approved, Investigational
Cisapride	The serum concentration of Cisapride can be increased when it is combined with Fusidic Acid.	Approved, Investigational, Withdrawn
Citalopram	The serum concentration of Citalopram can be increased when it is combined with Fusidic Acid.	Approved
Clarithromycin	The serum concentration of Clarithromycin can be increased when it is combined with Fusidic Acid.	Approved
Clevidipine	The serum concentration of Clevidipine can be increased when it is combined with Fusidic Acid.	Approved, Investigational
Clindamycin	The serum concentration of Clindamycin can be increased when it is combined with Fusidic Acid.	Approved, Vet Approved
Clobazam	The serum concentration of Clobazam can be increased when it is combined with Fusidic Acid.	Approved, Illicit
Clofazimine	The serum concentration of Clofazimine can be increased when it is combined with Fusidic Acid.	Approved, Investigational
Clofibrate	The serum concentration of Clofibrate can be increased when it is combined with Fusidic Acid.	Approved, Investigational
clomethiazole	The serum concentration of clomethiazole can be increased when it is combined with Fusidic Acid.	Investigational
Clomipramine	The serum concentration of Clomipramine can be increased when it is combined with Fusidic Acid.	Approved, Investigational, Vet Approved
Clonazepam	The serum concentration of Clonazepam can be increased when it is combined with Fusidic Acid.	Approved, Illicit
Clonidine	The serum concentration of Clonidine can be increased when it is combined with Fusidic Acid.	Approved
Clopidogrel	The serum concentration of Clopidogrel can be increased when it is combined with Fusidic Acid.	Approved
Clorazepate	The serum concentration of Clorazepate can be increased when it is combined with Fusidic Acid.	Approved, Illicit
Clorindione	The serum concentration of Clorindione can be increased when it is combined with Fusidic Acid.	Experimental
Clotiazepam	The serum concentration of Clotiazepam can be increased when it is combined with Fusidic Acid.	Approved, Illicit
Clozapine	The serum concentration of Clozapine can be increased when it is combined with Fusidic Acid.	Approved
Cocaine	The serum concentration of Cocaine can be increased when it is combined with Fusidic Acid.	Approved, Illicit
Codeine	The serum concentration of Codeine can be increased when it is combined with Fusidic Acid.	Approved, Illicit
Colchicine	The serum concentration of Colchicine can be increased when it is combined with Fusidic Acid.	Approved
Conivaptan	The serum concentration of Conivaptan can be increased when it is combined with Fusidic Acid.	Approved, Investigational
Conjugated estrogens	The serum concentration of Conjugated estrogens can be increased when it is combined with Fusidic Acid.	Approved
Copanlisib	The serum concentration of Copanlisib can be increased when it is combined with Fusidic Acid.	Approved, Investigational
Cortisone acetate	The serum concentration of Cortisone acetate can be increased when it is combined with Fusidic Acid.	Approved, Investigational
Crizotinib	The serum concentration of Crizotinib can be increased when it is combined with Fusidic Acid.	Approved
Cyclandelate	The serum concentration of Cyclandelate can be increased when it is combined with Fusidic Acid.	Approved
Cyclobenzaprine	The serum concentration of Cyclobenzaprine can be increased when it is combined with Fusidic Acid.	Approved
Cyclophosphamide	The serum concentration of Cyclophosphamide can be increased when it is combined with Fusidic Acid.	Approved, Investigational
Cyclosporine	The serum concentration of Cyclosporine can be increased when it is combined with Fusidic Acid.	Approved, Investigational, Vet Approved
Cytarabine	The serum concentration of Cytarabine can be increased when it is combined with Fusidic Acid.	Approved, Investigational
Dabrafenib	The serum concentration of Dabrafenib can be increased when it is combined with Fusidic Acid.	Approved, Investigational
Daclatasvir	The serum concentration of Daclatasvir can be increased when it is combined with Fusidic Acid.	Approved, Investigational
Dantrolene	The serum concentration of Dantrolene can be increased when it is combined with Fusidic Acid.	Approved, Investigational
Dapagliflozin	The serum concentration of Dapagliflozin can be increased when it is combined with Fusidic Acid.	Approved
Dapsone	The serum concentration of Dapsone can be increased when it is combined with Fusidic Acid.	Approved, Investigational
Darifenacin	The serum concentration of Darifenacin can be increased when it is combined with Fusidic Acid.	Approved, Investigational
Darodipine	The serum concentration of Darodipine can be increased when it is combined with Fusidic Acid.	Experimental
Darunavir	The serum concentration of Darunavir can be increased when it is combined with Fusidic Acid.	Approved
Dasabuvir	The serum concentration of Dasabuvir can be increased when it is combined with Fusidic Acid.	Approved
Dasatinib	The serum concentration of Dasatinib can be increased when it is combined with Fusidic Acid.	Approved, Investigational
Daunorubicin	The serum concentration of Daunorubicin can be increased when it is combined with Fusidic Acid.	Approved
Deflazacort	The serum concentration of Deflazacort can be increased when it is combined with Fusidic Acid.	Approved, Investigational
Delamanid	The serum concentration of Delamanid can be increased when it is combined with Fusidic Acid.	Approved, Investigational
Delavirdine	The serum concentration of Delavirdine can be increased when it is combined with Fusidic Acid.	Approved
Desvenlafaxine	The serum concentration of Desvenlafaxine can be increased when it is combined with Fusidic Acid.	Approved, Investigational
Deutetrabenazine	The serum concentration of Deutetrabenazine can be increased when it is combined with Fusidic Acid.	Approved, Investigational
Dexamethasone	The serum concentration of Dexamethasone can be increased when it is combined with Fusidic Acid.	Approved, Investigational, Vet Approved
Dexchlorpheniramine maleate	The serum concentration of Dexchlorpheniramine maleate can be increased when it is combined with Fusidic Acid.	Approved
Dexlansoprazole	The serum concentration of Dexlansoprazole can be increased when it is combined with Fusidic Acid.	Approved, Investigational
Dexniguldipine	The serum concentration of Dexniguldipine can be increased when it is combined with Fusidic Acid.	Experimental
Dextromethorphan	The serum concentration of Dextromethorphan can be increased when it is combined with Fusidic Acid.	Approved
Dextropropoxyphene	The serum concentration of Dextropropoxyphene can be increased when it is combined with Fusidic Acid.	Approved, Illicit, Investigational, Withdrawn
Dexverapamil	The serum concentration of Dexverapamil can be increased when it is combined with Fusidic Acid.	Experimental
Diazepam	The serum concentration of Diazepam can be increased when it is combined with Fusidic Acid.	Approved, Illicit, Investigational, Vet Approved
Diclofenac	The serum concentration of Diclofenac can be increased when it is combined with Fusidic Acid.	Approved, Vet Approved
Dicoumarol	The serum concentration of Dicoumarol can be increased when it is combined with Fusidic Acid.	Approved
Dienogest	The serum concentration of Dienogest can be increased when it is combined with Fusidic Acid.	Approved
Digitoxin	The serum concentration of Digitoxin can be increased when it is combined with Fusidic Acid.	Approved, Investigational
Digoxin	The serum concentration of Digoxin can be increased when it is combined with Fusidic Acid.	Approved
Dihydro-alpha-ergocryptine	The serum concentration of Dihydro-alpha-ergocryptine can be increased when it is combined with Fusidic Acid.	Approved
Dihydrocodeine	The serum concentration of Dihydrocodeine can be increased when it is combined with Fusidic Acid.	Approved, Illicit
Dihydroergotamine	The serum concentration of Dihydroergotamine can be increased when it is combined with Fusidic Acid.	Approved, Investigational
Diltiazem	The serum concentration of Diltiazem can be increased when it is combined with Fusidic Acid.	Approved, Investigational
Diphenadione	The serum concentration of Diphenadione can be increased when it is combined with Fusidic Acid.	Experimental
Disopyramide	The serum concentration of Disopyramide can be increased when it is combined with Fusidic Acid.	Approved
Disulfiram	The serum concentration of Disulfiram can be increased when it is combined with Fusidic Acid.	Approved
Docetaxel	The serum concentration of Docetaxel can be increased when it is combined with Fusidic Acid.	Approved, Investigational
Dofetilide	The serum concentration of Dofetilide can be increased when it is combined with Fusidic Acid.	Approved, Investigational
Dolasetron	The serum concentration of Dolasetron can be increased when it is combined with Fusidic Acid.	Approved, Investigational
Domperidone	The serum concentration of Domperidone can be increased when it is combined with Fusidic Acid.	Approved, Investigational, Vet Approved
Donepezil	The serum concentration of Donepezil can be increased when it is combined with Fusidic Acid.	Approved
Dorzolamide	The serum concentration of Dorzolamide can be increased when it is combined with Fusidic Acid.	Approved
Dotarizine	The serum concentration of Dotarizine can be increased when it is combined with Fusidic Acid.	Investigational
Doxepin	The serum concentration of Doxepin can be increased when it is combined with Fusidic Acid.	Approved, Investigational
Doxorubicin	The serum concentration of Doxorubicin can be increased when it is combined with Fusidic Acid.	Approved, Investigational
Dronabinol	The serum concentration of Dronabinol can be increased when it is combined with Fusidic Acid.	Approved, Illicit
Dronedarone	The serum concentration of Dronedarone can be increased when it is combined with Fusidic Acid.	Approved
Dutasteride	The serum concentration of Dutasteride can be increased when it is combined with Fusidic Acid.	Approved, Investigational
Efavirenz	The serum concentration of Efavirenz can be increased when it is combined with Fusidic Acid.	Approved, Investigational
Efonidipine	The serum concentration of Efonidipine can be increased when it is combined with Fusidic Acid.	Approved, Investigational
Elbasvir	The serum concentration of Elbasvir can be increased when it is combined with Fusidic Acid.	Approved
Eletriptan	The serum concentration of Eletriptan can be increased when it is combined with Fusidic Acid.	Approved, Investigational
Eliglustat	The serum concentration of Eliglustat can be increased when it is combined with Fusidic Acid.	Approved
Elvitegravir	The serum concentration of Elvitegravir can be increased when it is combined with Fusidic Acid.	Approved
Emopamil	The serum concentration of Emopamil can be increased when it is combined with Fusidic Acid.	Experimental
Enalapril	The serum concentration of Enalapril can be increased when it is combined with Fusidic Acid.	Approved, Vet Approved
Enasidenib	The serum concentration of Enasidenib can be increased when it is combined with Fusidic Acid.	Approved, Investigational
Enzalutamide	The serum concentration of Enzalutamide can be increased when it is combined with Fusidic Acid.	Approved
Eperisone	The serum concentration of Eperisone can be increased when it is combined with Fusidic Acid.	Approved, Investigational
Epinastine	The serum concentration of Epinastine can be increased when it is combined with Fusidic Acid.	Approved, Investigational
Eplerenone	The serum concentration of Eplerenone can be increased when it is combined with Fusidic Acid.	Approved
Ergocalciferol	The serum concentration of Ergocalciferol can be increased when it is combined with Fusidic Acid.	Approved, Nutraceutical
Ergoloid mesylate	The serum concentration of Ergoloid mesylate can be increased when it is combined with Fusidic Acid.	Approved
Ergonovine	The serum concentration of Ergonovine can be increased when it is combined with Fusidic Acid.	Approved
Ergotamine	The serum concentration of Ergotamine can be increased when it is combined with Fusidic Acid.	Approved
Erlotinib	The serum concentration of Erlotinib can be increased when it is combined with Fusidic Acid.	Approved, Investigational
Erythromycin	The serum concentration of Erythromycin can be increased when it is combined with Fusidic Acid.	Approved, Investigational, Vet Approved
Escitalopram	The serum concentration of Escitalopram can be increased when it is combined with Fusidic Acid.	Approved, Investigational
Esomeprazole	The serum concentration of Esomeprazole can be increased when it is combined with Fusidic Acid.	Approved, Investigational
Estazolam	The serum concentration of Estazolam can be increased when it is combined with Fusidic Acid.	Approved, Illicit
Estradiol	The serum concentration of Estradiol can be increased when it is combined with Fusidic Acid.	Approved, Investigational, Vet Approved
Estradiol acetate	The serum concentration of Estradiol acetate can be increased when it is combined with Fusidic Acid.	Approved, Investigational, Vet Approved
Estradiol benzoate	The serum concentration of Estradiol benzoate can be increased when it is combined with Fusidic Acid.	Approved, Investigational, Vet Approved
Estradiol cypionate	The serum concentration of Estradiol cypionate can be increased when it is combined with Fusidic Acid.	Approved, Investigational, Vet Approved
Estradiol dienanthate	The serum concentration of Estradiol dienanthate can be increased when it is combined with Fusidic Acid.	Approved, Investigational, Vet Approved
Estradiol valerate	The serum concentration of Estradiol valerate can be increased when it is combined with Fusidic Acid.	Approved, Investigational, Vet Approved
Estramustine	The serum concentration of Estramustine can be increased when it is combined with Fusidic Acid.	Approved, Investigational
Estrogens, esterified	The serum concentration of Estrogens, esterified can be increased when it is combined with Fusidic Acid.	Approved
Estrone	The serum concentration of Estrone can be increased when it is combined with Fusidic Acid.	Approved
Estrone sulfate	The serum concentration of Estrone sulfate can be increased when it is combined with Fusidic Acid.	Approved
Eszopiclone	The serum concentration of Eszopiclone can be increased when it is combined with Fusidic Acid.	Approved, Investigational
Ethanol	The serum concentration of Ethanol can be increased when it is combined with Fusidic Acid.	Approved
Ethinyl Estradiol	The serum concentration of Ethinyl Estradiol can be increased when it is combined with Fusidic Acid.	Approved
Ethosuximide	The serum concentration of Ethosuximide can be increased when it is combined with Fusidic Acid.	Approved
Ethyl biscoumacetate	The serum concentration of Ethyl biscoumacetate can be increased when it is combined with Fusidic Acid.	Withdrawn
Ethylmorphine	The serum concentration of Ethylmorphine can be increased when it is combined with Fusidic Acid.	Approved, Illicit
Etizolam	The serum concentration of Etizolam can be increased when it is combined with Fusidic Acid.	Approved
Etonogestrel	The serum concentration of Etonogestrel can be increased when it is combined with Fusidic Acid.	Approved, Investigational
Etoposide	The serum concentration of Etoposide can be increased when it is combined with Fusidic Acid.	Approved
Etoricoxib	The serum concentration of Etoricoxib can be increased when it is combined with Fusidic Acid.	Approved, Investigational
Etravirine	The serum concentration of Etravirine can be increased when it is combined with Fusidic Acid.	Approved
Everolimus	The serum concentration of Everolimus can be increased when it is combined with Fusidic Acid.	Approved
Exemestane	The serum concentration of Exemestane can be increased when it is combined with Fusidic Acid.	Approved, Investigational
Famciclovir	The serum concentration of Famciclovir can be increased when it is combined with Fusidic Acid.	Approved, Investigational
Felbamate	The serum concentration of Felbamate can be increased when it is combined with Fusidic Acid.	Approved
Felodipine	The serum concentration of Felodipine can be increased when it is combined with Fusidic Acid.	Approved, Investigational
Fendiline	The serum concentration of Fendiline can be increased when it is combined with Fusidic Acid.	Withdrawn
Fenofibrate	The serum concentration of Fenofibrate can be increased when it is combined with Fusidic Acid.	Approved
Fenofibric acid	The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Fusidic Acid is combined with Fenofibric acid.	Approved
Fentanyl	The serum concentration of Fentanyl can be increased when it is combined with Fusidic Acid.	Approved, Illicit, Investigational, Vet Approved
Fesoterodine	The serum concentration of Fesoterodine can be increased when it is combined with Fusidic Acid.	Approved
Finasteride	The serum concentration of Finasteride can be increased when it is combined with Fusidic Acid.	Approved
Fingolimod	The serum concentration of Fingolimod can be increased when it is combined with Fusidic Acid.	Approved, Investigational
Fish oil	The serum concentration of Fish oil can be increased when it is combined with Fusidic Acid.	Approved, Nutraceutical
Flibanserin	The serum concentration of Flibanserin can be increased when it is combined with Fusidic Acid.	Approved, Investigational
Fluindione	The serum concentration of Fluindione can be increased when it is combined with Fusidic Acid.	Approved, Investigational
Flunarizine	The serum concentration of Flunarizine can be increased when it is combined with Fusidic Acid.	Approved
Flunisolide	The serum concentration of Flunisolide can be increased when it is combined with Fusidic Acid.	Approved, Investigational
Flunitrazepam	The serum concentration of Flunitrazepam can be increased when it is combined with Fusidic Acid.	Approved, Illicit
Fluorometholone	The serum concentration of Fluorometholone can be increased when it is combined with Fusidic Acid.	Approved, Investigational
Fluoxetine	The serum concentration of Fluoxetine can be increased when it is combined with Fusidic Acid.	Approved, Vet Approved
Flurazepam	The serum concentration of Flurazepam can be increased when it is combined with Fusidic Acid.	Approved, Illicit, Investigational
Fluspirilene	The serum concentration of Fluspirilene can be increased when it is combined with Fusidic Acid.	Approved, Investigational
Flutamide	The serum concentration of Flutamide can be increased when it is combined with Fusidic Acid.	Approved, Investigational
Fluticasone furoate	The serum concentration of Fluticasone furoate can be increased when it is combined with Fusidic Acid.	Approved
Fluticasone propionate	The serum concentration of Fluticasone propionate can be increased when it is combined with Fusidic Acid.	Approved
Fluvastatin	The serum concentration of Fluvastatin can be increased when it is combined with Fusidic Acid.	Approved
Fosamprenavir	The serum concentration of Fosamprenavir can be increased when it is combined with Fusidic Acid.	Approved
Fosnetupitant	The serum concentration of Fosnetupitant can be increased when it is combined with Fusidic Acid.	Approved
Fostamatinib	The serum concentration of Fostamatinib can be increased when it is combined with Fusidic Acid.	Approved, Investigational
Fulvestrant	The serum concentration of Fulvestrant can be increased when it is combined with Fusidic Acid.	Approved, Investigational
Gabapentin	The serum concentration of Gabapentin can be increased when it is combined with Fusidic Acid.	Approved, Investigational
Galantamine	The serum concentration of Galantamine can be increased when it is combined with Fusidic Acid.	Approved
Gallopamil	The serum concentration of Gallopamil can be increased when it is combined with Fusidic Acid.	Investigational
Gefitinib	The serum concentration of Gefitinib can be increased when it is combined with Fusidic Acid.	Approved, Investigational
Gemfibrozil	The serum concentration of Gemfibrozil can be increased when it is combined with Fusidic Acid.	Approved
Glipizide	The serum concentration of Glipizide can be increased when it is combined with Fusidic Acid.	Approved, Investigational
Glyburide	The serum concentration of Glyburide can be increased when it is combined with Fusidic Acid.	Approved
Granisetron	The serum concentration of Granisetron can be increased when it is combined with Fusidic Acid.	Approved, Investigational
Grazoprevir	The serum concentration of Grazoprevir can be increased when it is combined with Fusidic Acid.	Approved
Grepafloxacin	The serum concentration of Grepafloxacin can be increased when it is combined with Fusidic Acid.	Approved, Investigational, Withdrawn
Guanfacine	The serum concentration of Guanfacine can be increased when it is combined with Fusidic Acid.	Approved, Investigational
Halofantrine	The serum concentration of Halofantrine can be increased when it is combined with Fusidic Acid.	Approved
Haloperidol	The serum concentration of Haloperidol can be increased when it is combined with Fusidic Acid.	Approved
Halothane	The serum concentration of Halothane can be increased when it is combined with Fusidic Acid.	Approved, Vet Approved
Hexobarbital	The serum concentration of Hexobarbital can be increased when it is combined with Fusidic Acid.	Approved
Histamine	The serum concentration of Histamine can be increased when it is combined with Fusidic Acid.	Approved, Investigational
Hydrocodone	The serum concentration of Hydrocodone can be increased when it is combined with Fusidic Acid.	Approved, Illicit
Hydrocortisone	The serum concentration of Hydrocortisone can be increased when it is combined with Fusidic Acid.	Approved, Vet Approved
Hydrocortisone acetate	The serum concentration of Hydrocortisone acetate can be increased when it is combined with Fusidic Acid.	Approved, Vet Approved
Hydrocortisone butyrate	The serum concentration of Hydrocortisone butyrate can be increased when it is combined with Fusidic Acid.	Approved, Vet Approved
Hydromorphone	The serum concentration of Hydromorphone can be increased when it is combined with Fusidic Acid.	Approved, Illicit
Hydroxyprogesterone caproate	The serum concentration of Hydroxyprogesterone caproate can be increased when it is combined with Fusidic Acid.	Approved, Investigational
Ibrutinib	The serum concentration of Ibrutinib can be increased when it is combined with Fusidic Acid.	Approved
Icotinib	The serum concentration of Icotinib can be increased when it is combined with Fusidic Acid.	Approved, Investigational
Ifosfamide	The serum concentration of Ifosfamide can be increased when it is combined with Fusidic Acid.	Approved
Iloperidone	The serum concentration of Iloperidone can be increased when it is combined with Fusidic Acid.	Approved
Imatinib	The serum concentration of Imatinib can be increased when it is combined with Fusidic Acid.	Approved
Imidafenacin	The serum concentration of Imidafenacin can be increased when it is combined with Fusidic Acid.	Approved, Investigational
Imipramine	The serum concentration of Imipramine can be increased when it is combined with Fusidic Acid.	Approved
Imiquimod	The serum concentration of Imiquimod can be increased when it is combined with Fusidic Acid.	Approved, Investigational
Indacaterol	The serum concentration of Indacaterol can be increased when it is combined with Fusidic Acid.	Approved
Indapamide	The serum concentration of Indapamide can be increased when it is combined with Fusidic Acid.	Approved
Indinavir	The serum concentration of Indinavir can be increased when it is combined with Fusidic Acid.	Approved
Ipecac	The serum concentration of Ipecac can be increased when it is combined with Fusidic Acid.	Approved, Withdrawn
Ipratropium	The serum concentration of Ipratropium can be increased when it is combined with Fusidic Acid.	Approved
Irinotecan	The serum concentration of Irinotecan can be increased when it is combined with Fusidic Acid.	Approved, Investigational
Isavuconazole	The serum concentration of Isavuconazole can be increased when it is combined with Fusidic Acid.	Approved, Investigational
Isavuconazonium	The serum concentration of Isavuconazonium can be increased when it is combined with Fusidic Acid.	Approved, Investigational
Isosorbide Dinitrate	The serum concentration of Isosorbide Dinitrate can be increased when it is combined with Fusidic Acid.	Approved, Investigational
Isosorbide Mononitrate	The serum concentration of Isosorbide Mononitrate can be increased when it is combined with Fusidic Acid.	Approved
Isradipine	The serum concentration of Isradipine can be increased when it is combined with Fusidic Acid.	Approved, Investigational
Itraconazole	The serum concentration of Itraconazole can be increased when it is combined with Fusidic Acid.	Approved, Investigational
Ivabradine	The serum concentration of Ivabradine can be increased when it is combined with Fusidic Acid.	Approved
Ivacaftor	The serum concentration of Ivacaftor can be increased when it is combined with Fusidic Acid.	Approved
Ivermectin	The serum concentration of Ivermectin can be increased when it is combined with Fusidic Acid.	Approved, Investigational, Vet Approved
Ixabepilone	The serum concentration of Ixabepilone can be increased when it is combined with Fusidic Acid.	Approved, Investigational
Ixazomib	The serum concentration of Ixazomib can be increased when it is combined with Fusidic Acid.	Approved, Investigational
Ketamine	The serum concentration of Ketamine can be increased when it is combined with Fusidic Acid.	Approved, Vet Approved
Ketazolam	The serum concentration of Ketazolam can be increased when it is combined with Fusidic Acid.	Approved
Ketobemidone	The serum concentration of Ketobemidone can be increased when it is combined with Fusidic Acid.	Approved, Investigational
Ketoconazole	The serum concentration of Ketoconazole can be increased when it is combined with Fusidic Acid.	Approved, Investigational
Lacidipine	The serum concentration of Lacidipine can be increased when it is combined with Fusidic Acid.	Approved, Investigational
Lamotrigine	The serum concentration of Lamotrigine can be increased when it is combined with Fusidic Acid.	Approved, Investigational
Lansoprazole	The serum concentration of Lansoprazole can be increased when it is combined with Fusidic Acid.	Approved, Investigational
Lapatinib	The serum concentration of Lapatinib can be increased when it is combined with Fusidic Acid.	Approved, Investigational
Laquinimod	The serum concentration of Laquinimod can be increased when it is combined with Fusidic Acid.	Investigational
Lenvatinib	The serum concentration of Lenvatinib can be increased when it is combined with Fusidic Acid.	Approved, Investigational
Lercanidipine	The serum concentration of Lercanidipine can be increased when it is combined with Fusidic Acid.	Approved, Investigational
Letrozole	The serum concentration of Letrozole can be increased when it is combined with Fusidic Acid.	Approved, Investigational
Levetiracetam	The serum concentration of Levetiracetam can be increased when it is combined with Fusidic Acid.	Approved, Investigational
Levobupivacaine	The serum concentration of Levobupivacaine can be increased when it is combined with Fusidic Acid.	Approved, Investigational
Levocetirizine	The serum concentration of Levocetirizine can be increased when it is combined with Fusidic Acid.	Approved
Levomethadyl Acetate	The serum concentration of Levomethadyl Acetate can be increased when it is combined with Fusidic Acid.	Approved, Investigational
Levomilnacipran	The serum concentration of Levomilnacipran can be increased when it is combined with Fusidic Acid.	Approved, Investigational
Levonorgestrel	The serum concentration of Levonorgestrel can be increased when it is combined with Fusidic Acid.	Approved, Investigational
Levothyroxine	The serum concentration of Levothyroxine can be increased when it is combined with Fusidic Acid.	Approved
Lidocaine	The serum concentration of Lidocaine can be increased when it is combined with Fusidic Acid.	Approved, Vet Approved
Lidoflazine	The serum concentration of Lidoflazine can be increased when it is combined with Fusidic Acid.	Experimental
Lisuride	The serum concentration of Lisuride can be increased when it is combined with Fusidic Acid.	Approved, Investigational
Lomerizine	The serum concentration of Lomerizine can be increased when it is combined with Fusidic Acid.	Experimental
Lomitapide	The serum concentration of Lomitapide can be increased when it is combined with Fusidic Acid.	Approved, Investigational
Loperamide	The serum concentration of Loperamide can be increased when it is combined with Fusidic Acid.	Approved
Lopinavir	The serum concentration of Lopinavir can be increased when it is combined with Fusidic Acid.	Approved
Loratadine	The serum concentration of Loratadine can be increased when it is combined with Fusidic Acid.	Approved, Investigational
Lorcaserin	The serum concentration of Lorcaserin can be increased when it is combined with Fusidic Acid.	Approved
Lorpiprazole	The serum concentration of Lorpiprazole can be increased when it is combined with Fusidic Acid.	Approved
Losartan	The serum concentration of Losartan can be increased when it is combined with Fusidic Acid.	Approved
Lovastatin	The serum concentration of Lovastatin can be increased when it is combined with Fusidic Acid.	Approved, Investigational
Lumefantrine	The serum concentration of Lumefantrine can be increased when it is combined with Fusidic Acid.	Approved
Lurasidone	The serum concentration of Lurasidone can be increased when it is combined with Fusidic Acid.	Approved, Investigational
Macimorelin	The serum concentration of Macimorelin can be increased when it is combined with Fusidic Acid.	Approved, Investigational
Macitentan	The serum concentration of Macitentan can be increased when it is combined with Fusidic Acid.	Approved
Magnesium sulfate	The serum concentration of Magnesium sulfate can be increased when it is combined with Fusidic Acid.	Approved, Investigational, Vet Approved
Manidipine	The serum concentration of Manidipine can be increased when it is combined with Fusidic Acid.	Approved, Investigational
Maraviroc	The serum concentration of Maraviroc can be increased when it is combined with Fusidic Acid.	Approved, Investigational
Mebendazole	The serum concentration of Mebendazole can be increased when it is combined with Fusidic Acid.	Approved, Vet Approved
Medical Cannabis	The serum concentration of Medical Cannabis can be increased when it is combined with Fusidic Acid.	Experimental, Investigational
Medroxyprogesterone acetate	The serum concentration of Medroxyprogesterone acetate can be increased when it is combined with Fusidic Acid.	Approved, Investigational
Mefloquine	The serum concentration of Mefloquine can be increased when it is combined with Fusidic Acid.	Approved, Investigational
Meloxicam	The serum concentration of Meloxicam can be increased when it is combined with Fusidic Acid.	Approved, Vet Approved
Menthol	The serum concentration of Menthol can be increased when it is combined with Fusidic Acid.	Approved
Methadone	The serum concentration of Methadone can be increased when it is combined with Fusidic Acid.	Approved
Methaqualone	The serum concentration of Methaqualone can be increased when it is combined with Fusidic Acid.	Illicit, Withdrawn
Methoxsalen	The serum concentration of Methoxsalen can be increased when it is combined with Fusidic Acid.	Approved
Methoxyflurane	The serum concentration of Methoxyflurane can be increased when it is combined with Fusidic Acid.	Approved, Investigational, Vet Approved
Methylprednisolone	The serum concentration of Methylprednisolone can be increased when it is combined with Fusidic Acid.	Approved, Vet Approved
Methyltestosterone	The serum concentration of Methyltestosterone can be increased when it is combined with Fusidic Acid.	Approved
Metronidazole	The serum concentration of Metronidazole can be increased when it is combined with Fusidic Acid.	Approved
Mevastatin	The risk or severity of adverse effects can be increased when Fusidic Acid is combined with Mevastatin.	Experimental
Mexiletine	The serum concentration of Mexiletine can be increased when it is combined with Fusidic Acid.	Approved, Investigational
Mianserin	The serum concentration of Mianserin can be increased when it is combined with Fusidic Acid.	Approved, Investigational
Mibefradil	The serum concentration of Mibefradil can be increased when it is combined with Fusidic Acid.	Investigational, Withdrawn
Miconazole	The serum concentration of Miconazole can be increased when it is combined with Fusidic Acid.	Approved, Investigational, Vet Approved
Midazolam	The serum concentration of Midazolam can be increased when it is combined with Fusidic Acid.	Approved, Illicit
Midecamycin	The serum concentration of Midecamycin can be increased when it is combined with Fusidic Acid.	Approved
Midostaurin	The serum concentration of Midostaurin can be increased when it is combined with Fusidic Acid.	Approved, Investigational
Mifepristone	The serum concentration of Mifepristone can be increased when it is combined with Fusidic Acid.	Approved, Investigational
Mirabegron	The serum concentration of Mirabegron can be increased when it is combined with Fusidic Acid.	Approved
Mirtazapine	The serum concentration of Mirtazapine can be increased when it is combined with Fusidic Acid.	Approved
Modafinil	The serum concentration of Modafinil can be increased when it is combined with Fusidic Acid.	Approved, Investigational
Montelukast	The serum concentration of Montelukast can be increased when it is combined with Fusidic Acid.	Approved
Morphine	The serum concentration of Morphine can be increased when it is combined with Fusidic Acid.	Approved, Investigational
Mycophenolate mofetil	The serum concentration of Mycophenolate mofetil can be increased when it is combined with Fusidic Acid.	Approved, Investigational
Nabiximols	The serum concentration of Nabiximols can be increased when it is combined with Fusidic Acid.	Approved, Investigational
Naftopidil	The serum concentration of Naftopidil can be increased when it is combined with Fusidic Acid.	Investigational
Naloxegol	The serum concentration of Naloxegol can be increased when it is combined with Fusidic Acid.	Approved
Naloxone	The serum concentration of Naloxone can be increased when it is combined with Fusidic Acid.	Approved, Vet Approved
Nateglinide	The serum concentration of Nateglinide can be increased when it is combined with Fusidic Acid.	Approved, Investigational
Nefazodone	The serum concentration of Nefazodone can be increased when it is combined with Fusidic Acid.	Approved, Withdrawn
Nelfinavir	The serum concentration of Nelfinavir can be increased when it is combined with Fusidic Acid.	Approved
Neratinib	The serum concentration of Neratinib can be increased when it is combined with Fusidic Acid.	Approved, Investigational
Nevirapine	The serum concentration of Nevirapine can be increased when it is combined with Fusidic Acid.	Approved
Nicardipine	The serum concentration of Nicardipine can be increased when it is combined with Fusidic Acid.	Approved, Investigational
Nicotine	The serum concentration of Nicotine can be increased when it is combined with Fusidic Acid.	Approved
Nifedipine	The serum concentration of Nifedipine can be increased when it is combined with Fusidic Acid.	Approved
Niguldipine	The serum concentration of Niguldipine can be increased when it is combined with Fusidic Acid.	Experimental
Nilotinib	The serum concentration of Nilotinib can be increased when it is combined with Fusidic Acid.	Approved, Investigational
Niludipine	The serum concentration of Niludipine can be increased when it is combined with Fusidic Acid.	Experimental
Nilvadipine	The serum concentration of Nilvadipine can be increased when it is combined with Fusidic Acid.	Approved, Investigational
Nimesulide	The serum concentration of Nimesulide can be increased when it is combined with Fusidic Acid.	Approved, Investigational, Withdrawn
Nimodipine	The serum concentration of Nimodipine can be increased when it is combined with Fusidic Acid.	Approved, Investigational
Nisoldipine	The serum concentration of Nisoldipine can be increased when it is combined with Fusidic Acid.	Approved
Nitrazepam	The serum concentration of Nitrazepam can be increased when it is combined with Fusidic Acid.	Approved
Nitrendipine	The serum concentration of Nitrendipine can be increased when it is combined with Fusidic Acid.	Approved, Investigational
Norethisterone	The serum concentration of Norethisterone can be increased when it is combined with Fusidic Acid.	Approved
Norgestrel	The serum concentration of Norgestrel can be increased when it is combined with Fusidic Acid.	Approved
Nortriptyline	The serum concentration of Nortriptyline can be increased when it is combined with Fusidic Acid.	Approved
Nylidrin	The serum concentration of Nylidrin can be increased when it is combined with Fusidic Acid.	Approved
Odanacatib	The serum concentration of Odanacatib can be increased when it is combined with Fusidic Acid.	Investigational
Olaparib	The serum concentration of Olaparib can be increased when it is combined with Fusidic Acid.	Approved
Olopatadine	The serum concentration of Olopatadine can be increased when it is combined with Fusidic Acid.	Approved
Omeprazole	The serum concentration of Omeprazole can be increased when it is combined with Fusidic Acid.	Approved, Investigational, Vet Approved
Ondansetron	The serum concentration of Ondansetron can be increased when it is combined with Fusidic Acid.	Approved
Opium	The serum concentration of Opium can be increased when it is combined with Fusidic Acid.	Approved, Illicit
Orphenadrine	The serum concentration of Orphenadrine can be increased when it is combined with Fusidic Acid.	Approved
Ospemifene	The serum concentration of Ospemifene can be increased when it is combined with Fusidic Acid.	Approved, Investigational
Otilonium	The serum concentration of Otilonium can be increased when it is combined with Fusidic Acid.	Experimental, Investigational
Oxazepam	The serum concentration of Oxazepam can be increased when it is combined with Fusidic Acid.	Approved
Oxybutynin	The serum concentration of Oxybutynin can be increased when it is combined with Fusidic Acid.	Approved, Investigational
Oxycodone	The serum concentration of Oxycodone can be increased when it is combined with Fusidic Acid.	Approved, Illicit, Investigational
Oxymorphone	The serum concentration of Oxymorphone can be increased when it is combined with Fusidic Acid.	Approved, Investigational, Vet Approved
Paclitaxel	The serum concentration of Paclitaxel can be increased when it is combined with Fusidic Acid.	Approved, Vet Approved
Palbociclib	The serum concentration of Palbociclib can be increased when it is combined with Fusidic Acid.	Approved, Investigational
Palonosetron	The serum concentration of Palonosetron can be increased when it is combined with Fusidic Acid.	Approved, Investigational
Panobinostat	The serum concentration of Panobinostat can be increased when it is combined with Fusidic Acid.	Approved, Investigational
Pantoprazole	The serum concentration of Pantoprazole can be increased when it is combined with Fusidic Acid.	Approved
Paramethadione	The serum concentration of Paramethadione can be increased when it is combined with Fusidic Acid.	Approved
Paramethasone	The serum concentration of Paramethasone can be increased when it is combined with Fusidic Acid.	Approved
Parecoxib	The serum concentration of Parecoxib can be increased when it is combined with Fusidic Acid.	Approved
Paricalcitol	The serum concentration of Paricalcitol can be increased when it is combined with Fusidic Acid.	Approved, Investigational
Paritaprevir	The serum concentration of Paritaprevir can be increased when it is combined with Fusidic Acid.	Approved, Investigational
Pazopanib	The serum concentration of Pazopanib can be increased when it is combined with Fusidic Acid.	Approved
Penfluridol	The serum concentration of Penfluridol can be increased when it is combined with Fusidic Acid.	Experimental
Pentamidine	The serum concentration of Pentamidine can be increased when it is combined with Fusidic Acid.	Approved, Investigational
Perampanel	The serum concentration of Perampanel can be increased when it is combined with Fusidic Acid.	Approved
Pergolide	The serum concentration of Pergolide can be increased when it is combined with Fusidic Acid.	Approved, Investigational, Vet Approved, Withdrawn
Perhexiline	The serum concentration of Perhexiline can be increased when it is combined with Fusidic Acid.	Approved, Investigational
Permethrin	The serum concentration of Permethrin can be increased when it is combined with Fusidic Acid.	Approved, Investigational
Perospirone	The serum concentration of Perospirone can be increased when it is combined with Fusidic Acid.	Approved
Perphenazine	The serum concentration of Perphenazine can be increased when it is combined with Fusidic Acid.	Approved
Pethidine	The serum concentration of Pethidine can be increased when it is combined with Fusidic Acid.	Approved
Phenacetin	The serum concentration of Phenacetin can be increased when it is combined with Fusidic Acid.	Withdrawn
Phenindione	The serum concentration of Phenindione can be increased when it is combined with Fusidic Acid.	Approved, Investigational
Phenoxybenzamine	The serum concentration of Phenoxybenzamine can be increased when it is combined with Fusidic Acid.	Approved
Phenprocoumon	The serum concentration of Phenprocoumon can be increased when it is combined with Fusidic Acid.	Approved, Investigational
Phenytoin	The serum concentration of Phenytoin can be increased when it is combined with Fusidic Acid.	Approved, Vet Approved
Picosulfuric acid	The therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Fusidic Acid.	Approved
Pilocarpine	The serum concentration of Pilocarpine can be increased when it is combined with Fusidic Acid.	Approved, Investigational
Pimecrolimus	The serum concentration of Pimecrolimus can be increased when it is combined with Fusidic Acid.	Approved, Investigational
Pimozide	The serum concentration of Pimozide can be increased when it is combined with Fusidic Acid.	Approved
Pinacidil	The serum concentration of Pinacidil can be increased when it is combined with Fusidic Acid.	Approved
Pinaverium	The serum concentration of Pinaverium can be increased when it is combined with Fusidic Acid.	Approved
Pioglitazone	The serum concentration of Pioglitazone can be increased when it is combined with Fusidic Acid.	Approved, Investigational
Piperaquine	The serum concentration of Piperaquine can be increased when it is combined with Fusidic Acid.	Approved, Investigational
Pipotiazine	The serum concentration of Pipotiazine can be increased when it is combined with Fusidic Acid.	Approved, Investigational
Pitavastatin	The risk or severity of adverse effects can be increased when Fusidic Acid is combined with Pitavastatin.	Approved
Pitolisant	The serum concentration of Pitolisant can be increased when it is combined with Fusidic Acid.	Approved, Investigational
Podofilox	The serum concentration of Podofilox can be increased when it is combined with Fusidic Acid.	Approved
Pomalidomide	The serum concentration of Pomalidomide can be increased when it is combined with Fusidic Acid.	Approved
Ponatinib	The serum concentration of Ponatinib can be increased when it is combined with Fusidic Acid.	Approved, Investigational
Posaconazole	The serum concentration of Posaconazole can be increased when it is combined with Fusidic Acid.	Approved, Investigational, Vet Approved
Prasterone	The serum concentration of Prasterone can be increased when it is combined with Fusidic Acid.	Approved, Investigational, Nutraceutical
Prasugrel	The serum concentration of Prasugrel can be increased when it is combined with Fusidic Acid.	Approved
Pravastatin	The serum concentration of Pravastatin can be increased when it is combined with Fusidic Acid.	Approved
Prazepam	The serum concentration of Prazepam can be increased when it is combined with Fusidic Acid.	Approved, Illicit
Praziquantel	The serum concentration of Praziquantel can be increased when it is combined with Fusidic Acid.	Approved, Investigational, Vet Approved
Prednisolone	The serum concentration of Prednisolone can be increased when it is combined with Fusidic Acid.	Approved, Vet Approved
Prednisone	The serum concentration of Prednisone can be increased when it is combined with Fusidic Acid.	Approved, Vet Approved
Pregabalin	The serum concentration of Pregabalin can be increased when it is combined with Fusidic Acid.	Approved, Illicit, Investigational
Prenylamine	The serum concentration of Prenylamine can be increased when it is combined with Fusidic Acid.	Withdrawn
Primaquine	The serum concentration of Primaquine can be increased when it is combined with Fusidic Acid.	Approved
Prochlorperazine	The serum concentration of Prochlorperazine can be increased when it is combined with Fusidic Acid.	Approved, Vet Approved
Progesterone	The serum concentration of Progesterone can be increased when it is combined with Fusidic Acid.	Approved, Vet Approved
Proguanil	The serum concentration of Proguanil can be increased when it is combined with Fusidic Acid.	Approved
Promazine	The serum concentration of Promazine can be increased when it is combined with Fusidic Acid.	Approved, Vet Approved
Propafenone	The serum concentration of Propafenone can be increased when it is combined with Fusidic Acid.	Approved
Propiverine	The serum concentration of Propiverine can be increased when it is combined with Fusidic Acid.	Approved, Investigational
Propofol	The serum concentration of Propofol can be increased when it is combined with Fusidic Acid.	Approved, Investigational, Vet Approved
Propranolol	The serum concentration of Propranolol can be increased when it is combined with Fusidic Acid.	Approved, Investigational
Pyrazinamide	The serum concentration of Pyrazinamide can be increased when it is combined with Fusidic Acid.	Approved, Investigational
Quazepam	The serum concentration of Quazepam can be increased when it is combined with Fusidic Acid.	Approved, Illicit
Quetiapine	The serum concentration of Quetiapine can be increased when it is combined with Fusidic Acid.	Approved
Quinacrine	The serum concentration of Quinacrine can be increased when it is combined with Fusidic Acid.	Approved, Investigational
Quinidine	The serum concentration of Quinidine can be increased when it is combined with Fusidic Acid.	Approved, Investigational
Quinine	The serum concentration of Quinine can be increased when it is combined with Fusidic Acid.	Approved
Rabeprazole	The serum concentration of Rabeprazole can be increased when it is combined with Fusidic Acid.	Approved, Investigational
Raloxifene	The serum concentration of Raloxifene can be increased when it is combined with Fusidic Acid.	Approved, Investigational
Ramelteon	The serum concentration of Ramelteon can be increased when it is combined with Fusidic Acid.	Approved, Investigational
Ranolazine	The serum concentration of Ranolazine can be increased when it is combined with Fusidic Acid.	Approved, Investigational
Reboxetine	The serum concentration of Reboxetine can be increased when it is combined with Fusidic Acid.	Approved, Investigational
Regorafenib	The serum concentration of Regorafenib can be increased when it is combined with Fusidic Acid.	Approved
Repaglinide	The serum concentration of Repaglinide can be increased when it is combined with Fusidic Acid.	Approved, Investigational
Retapamulin	The serum concentration of Retapamulin can be increased when it is combined with Fusidic Acid.	Approved
Rifabutin	The serum concentration of Rifabutin can be increased when it is combined with Fusidic Acid.	Approved, Investigational
Rifampicin	The serum concentration of Rifampicin can be increased when it is combined with Fusidic Acid.	Approved
Rilpivirine	The serum concentration of Rilpivirine can be increased when it is combined with Fusidic Acid.	Approved
Rimonabant	The serum concentration of Rimonabant can be increased when it is combined with Fusidic Acid.	Approved, Investigational
Riociguat	The serum concentration of Riociguat can be increased when it is combined with Fusidic Acid.	Approved
Risperidone	The serum concentration of Risperidone can be increased when it is combined with Fusidic Acid.	Approved, Investigational
Ritonavir	The serum concentration of Fusidic Acid can be increased when it is combined with Ritonavir.	Approved, Investigational
Rivaroxaban	The serum concentration of Rivaroxaban can be increased when it is combined with Fusidic Acid.	Approved
Rofecoxib	The serum concentration of Rofecoxib can be increased when it is combined with Fusidic Acid.	Approved, Investigational, Withdrawn
Rolapitant	The serum concentration of Rolapitant can be increased when it is combined with Fusidic Acid.	Approved, Investigational
Romidepsin	The serum concentration of Romidepsin can be increased when it is combined with Fusidic Acid.	Approved, Investigational
Ropinirole	The serum concentration of Ropinirole can be increased when it is combined with Fusidic Acid.	Approved, Investigational
Ropivacaine	The serum concentration of Ropivacaine can be increased when it is combined with Fusidic Acid.	Approved
Rosiglitazone	The serum concentration of Rosiglitazone can be increased when it is combined with Fusidic Acid.	Approved, Investigational
Rosuvastatin	The serum concentration of Rosuvastatin can be increased when it is combined with Fusidic Acid.	Approved
Rotigotine	The serum concentration of Rotigotine can be increased when it is combined with Fusidic Acid.	Approved
Roxithromycin	The serum concentration of Roxithromycin can be increased when it is combined with Fusidic Acid.	Approved, Investigational, Withdrawn
Rucaparib	The serum concentration of Rucaparib can be increased when it is combined with Fusidic Acid.	Approved, Investigational
Rupatadine	The serum concentration of Rupatadine can be increased when it is combined with Fusidic Acid.	Approved
Ruxolitinib	The serum concentration of Ruxolitinib can be increased when it is combined with Fusidic Acid.	Approved
Safinamide	The serum concentration of Safinamide can be increased when it is combined with Fusidic Acid.	Approved, Investigational
Salmeterol	The serum concentration of Salmeterol can be increased when it is combined with Fusidic Acid.	Approved
Saquinavir	The serum concentration of Fusidic Acid can be increased when it is combined with Saquinavir.	Approved, Investigational
Saxagliptin	The serum concentration of Saxagliptin can be increased when it is combined with Fusidic Acid.	Approved
Selegiline	The serum concentration of Selegiline can be increased when it is combined with Fusidic Acid.	Approved, Investigational, Vet Approved
Seletracetam	The serum concentration of Seletracetam can be increased when it is combined with Fusidic Acid.	Investigational
Selexipag	The serum concentration of Selexipag can be increased when it is combined with Fusidic Acid.	Approved
Seratrodast	The serum concentration of Seratrodast can be increased when it is combined with Fusidic Acid.	Approved
Sertindole	The serum concentration of Sertindole can be increased when it is combined with Fusidic Acid.	Approved, Investigational, Withdrawn
Sertraline	The serum concentration of Sertraline can be increased when it is combined with Fusidic Acid.	Approved
Sevoflurane	The serum concentration of Sevoflurane can be increased when it is combined with Fusidic Acid.	Approved, Vet Approved
Sibutramine	The serum concentration of Sibutramine can be increased when it is combined with Fusidic Acid.	Approved, Illicit, Investigational, Withdrawn
Sildenafil	The serum concentration of Sildenafil can be increased when it is combined with Fusidic Acid.	Approved, Investigational
Silodosin	The serum concentration of Silodosin can be increased when it is combined with Fusidic Acid.	Approved
Simvastatin	The serum concentration of Simvastatin can be increased when it is combined with Fusidic Acid.	Approved
Sirolimus	The serum concentration of Sirolimus can be increased when it is combined with Fusidic Acid.	Approved, Investigational
Sitagliptin	The serum concentration of Sitagliptin can be increased when it is combined with Fusidic Acid.	Approved, Investigational
Solifenacin	The serum concentration of Solifenacin can be increased when it is combined with Fusidic Acid.	Approved
Sonidegib	The serum concentration of Sonidegib can be increased when it is combined with Fusidic Acid.	Approved, Investigational
Sorafenib	The serum concentration of Sorafenib can be increased when it is combined with Fusidic Acid.	Approved, Investigational
Spiramycin	The serum concentration of Spiramycin can be increased when it is combined with Fusidic Acid.	Approved
Sufentanil	The serum concentration of Sufentanil can be increased when it is combined with Fusidic Acid.	Approved, Investigational
Sulfadiazine	The serum concentration of Sulfadiazine can be increased when it is combined with Fusidic Acid.	Approved, Investigational, Vet Approved
Sulfamethoxazole	The serum concentration of Sulfamethoxazole can be increased when it is combined with Fusidic Acid.	Approved
Sulfinpyrazone	The serum concentration of Sulfinpyrazone can be increased when it is combined with Fusidic Acid.	Approved
Sunitinib	The serum concentration of Sunitinib can be increased when it is combined with Fusidic Acid.	Approved, Investigational
Synthetic Conjugated Estrogens, A	The serum concentration of Synthetic Conjugated Estrogens, A can be increased when it is combined with Fusidic Acid.	Approved
Synthetic Conjugated Estrogens, B	The serum concentration of Synthetic Conjugated Estrogens, B can be increased when it is combined with Fusidic Acid.	Approved
Tacrolimus	The serum concentration of Tacrolimus can be increased when it is combined with Fusidic Acid.	Approved, Investigational
Tadalafil	The serum concentration of Tadalafil can be increased when it is combined with Fusidic Acid.	Approved, Investigational
Tamoxifen	The serum concentration of Tamoxifen can be increased when it is combined with Fusidic Acid.	Approved
Tamsulosin	The serum concentration of Tamsulosin can be increased when it is combined with Fusidic Acid.	Approved, Investigational
Tasosartan	The serum concentration of Tasosartan can be increased when it is combined with Fusidic Acid.	Approved
Taurochenodeoxycholic acid	The serum concentration of Taurochenodeoxycholic acid can be increased when it is combined with Fusidic Acid.	Experimental
Telaprevir	The serum concentration of Telaprevir can be increased when it is combined with Fusidic Acid.	Approved, Withdrawn
Telithromycin	The serum concentration of Telithromycin can be increased when it is combined with Fusidic Acid.	Approved
Temazepam	The serum concentration of Temazepam can be increased when it is combined with Fusidic Acid.	Approved, Investigational
Temsirolimus	The serum concentration of Temsirolimus can be increased when it is combined with Fusidic Acid.	Approved
Teniposide	The serum concentration of Teniposide can be increased when it is combined with Fusidic Acid.	Approved
Terbinafine	The serum concentration of Terbinafine can be increased when it is combined with Fusidic Acid.	Approved, Investigational, Vet Approved
Terfenadine	The serum concentration of Terfenadine can be increased when it is combined with Fusidic Acid.	Approved, Withdrawn
Terodiline	The serum concentration of Terodiline can be increased when it is combined with Fusidic Acid.	Experimental
Tesmilifene	The serum concentration of Tesmilifene can be increased when it is combined with Fusidic Acid.	Investigational
Testosterone	The serum concentration of Testosterone can be increased when it is combined with Fusidic Acid.	Approved, Investigational
Testosterone cypionate	The serum concentration of Testosterone cypionate can be increased when it is combined with Fusidic Acid.	Approved
Testosterone enanthate	The serum concentration of Testosterone enanthate can be increased when it is combined with Fusidic Acid.	Approved
Testosterone propionate	The serum concentration of Testosterone propionate can be increased when it is combined with Fusidic Acid.	Approved, Investigational, Vet Approved, Withdrawn
Testosterone undecanoate	The serum concentration of Testosterone undecanoate can be increased when it is combined with Fusidic Acid.	Approved, Investigational
Tetracycline	The serum concentration of Tetracycline can be increased when it is combined with Fusidic Acid.	Approved, Vet Approved
Tetrahydropalmatine	The serum concentration of Tetrahydropalmatine can be increased when it is combined with Fusidic Acid.	Investigational
Tetrandrine	The serum concentration of Tetrandrine can be increased when it is combined with Fusidic Acid.	Experimental
Tezacaftor	The serum concentration of Tezacaftor can be increased when it is combined with Fusidic Acid.	Approved, Investigational
Theophylline	The serum concentration of Theophylline can be increased when it is combined with Fusidic Acid.	Approved
Thiotepa	The serum concentration of Thiotepa can be increased when it is combined with Fusidic Acid.	Approved, Investigational
Tiagabine	The serum concentration of Tiagabine can be increased when it is combined with Fusidic Acid.	Approved, Investigational
Ticagrelor	The serum concentration of Ticagrelor can be increased when it is combined with Fusidic Acid.	Approved
Ticlopidine	The serum concentration of Ticlopidine can be increased when it is combined with Fusidic Acid.	Approved
Tinidazole	The serum concentration of Tinidazole can be increased when it is combined with Fusidic Acid.	Approved, Investigational
Tioclomarol	The serum concentration of Tioclomarol can be increased when it is combined with Fusidic Acid.	Experimental
Tiotropium	The serum concentration of Tiotropium can be increased when it is combined with Fusidic Acid.	Approved
Tipranavir	The serum concentration of Tipranavir can be increased when it is combined with Fusidic Acid.	Approved, Investigational
Tocofersolan	The serum concentration of Tocofersolan can be increased when it is combined with Fusidic Acid.	Approved
Tocopherol	The serum concentration of Tocopherol can be increased when it is combined with Fusidic Acid.	Approved, Investigational
Tofacitinib	The serum concentration of Tofacitinib can be increased when it is combined with Fusidic Acid.	Approved, Investigational
Tolfenamic Acid	The serum concentration of Tolfenamic Acid can be increased when it is combined with Fusidic Acid.	Approved, Investigational
Tolterodine	The serum concentration of Tolterodine can be increased when it is combined with Fusidic Acid.	Approved, Investigational
Tolvaptan	The serum concentration of Tolvaptan can be increased when it is combined with Fusidic Acid.	Approved
Toremifene	The serum concentration of Toremifene can be increased when it is combined with Fusidic Acid.	Approved, Investigational
Trabectedin	The serum concentration of Trabectedin can be increased when it is combined with Fusidic Acid.	Approved, Investigational
Tramadol	The serum concentration of Tramadol can be increased when it is combined with Fusidic Acid.	Approved, Investigational
Tranilast	The serum concentration of Tranilast can be increased when it is combined with Fusidic Acid.	Approved, Investigational
Trastuzumab emtansine	The serum concentration of Trastuzumab emtansine can be increased when it is combined with Fusidic Acid.	Approved, Investigational
Trazodone	The serum concentration of Trazodone can be increased when it is combined with Fusidic Acid.	Approved, Investigational
Tretinoin	The serum concentration of Tretinoin can be increased when it is combined with Fusidic Acid.	Approved, Investigational, Nutraceutical
Triamcinolone	The serum concentration of Triamcinolone can be increased when it is combined with Fusidic Acid.	Approved, Vet Approved
Triazolam	The serum concentration of Triazolam can be increased when it is combined with Fusidic Acid.	Approved, Investigational
Trimebutine	The serum concentration of Trimebutine can be increased when it is combined with Fusidic Acid.	Approved
Trimethadione	The serum concentration of Trimethadione can be increased when it is combined with Fusidic Acid.	Approved
Trimethoprim	The serum concentration of Trimethoprim can be increased when it is combined with Fusidic Acid.	Approved, Vet Approved
Trimipramine	The serum concentration of Trimipramine can be increased when it is combined with Fusidic Acid.	Approved
Troglitazone	The serum concentration of Troglitazone can be increased when it is combined with Fusidic Acid.	Investigational, Withdrawn
Troleandomycin	The serum concentration of Troleandomycin can be increased when it is combined with Fusidic Acid.	Approved
Udenafil	The serum concentration of Udenafil can be increased when it is combined with Fusidic Acid.	Approved, Investigational
Ulipristal	The serum concentration of Ulipristal can be increased when it is combined with Fusidic Acid.	Approved
Valbenazine	The serum concentration of Valbenazine can be increased when it is combined with Fusidic Acid.	Approved, Investigational
Valdecoxib	The serum concentration of Valdecoxib can be increased when it is combined with Fusidic Acid.	Approved, Investigational, Withdrawn
Valproic Acid	The serum concentration of Valproic Acid can be increased when it is combined with Fusidic Acid.	Approved, Investigational
Vandetanib	The serum concentration of Vandetanib can be increased when it is combined with Fusidic Acid.	Approved
Vanoxerine	The serum concentration of Vanoxerine can be increased when it is combined with Fusidic Acid.	Investigational
Vardenafil	The serum concentration of Vardenafil can be increased when it is combined with Fusidic Acid.	Approved
Velpatasvir	The serum concentration of Velpatasvir can be increased when it is combined with Fusidic Acid.	Approved, Investigational
Vemurafenib	The serum concentration of Vemurafenib can be increased when it is combined with Fusidic Acid.	Approved
Venetoclax	The serum concentration of Venetoclax can be increased when it is combined with Fusidic Acid.	Approved, Investigational
Venlafaxine	The serum concentration of Venlafaxine can be increased when it is combined with Fusidic Acid.	Approved
Verapamil	The serum concentration of Verapamil can be increased when it is combined with Fusidic Acid.	Approved
Vicriviroc	The serum concentration of Vicriviroc can be increased when it is combined with Fusidic Acid.	Investigational
Vilanterol	The serum concentration of Vilanterol can be increased when it is combined with Fusidic Acid.	Approved
Vilazodone	The serum concentration of Vilazodone can be increased when it is combined with Fusidic Acid.	Approved
Vinblastine	The serum concentration of Vinblastine can be increased when it is combined with Fusidic Acid.	Approved
Vincristine	The serum concentration of Vincristine can be increased when it is combined with Fusidic Acid.	Approved, Investigational
Vindesine	The serum concentration of Vindesine can be increased when it is combined with Fusidic Acid.	Approved, Investigational
Vinflunine	The serum concentration of Vinflunine can be increased when it is combined with Fusidic Acid.	Approved, Investigational
Vinorelbine	The serum concentration of Vinorelbine can be increased when it is combined with Fusidic Acid.	Approved, Investigational
Vinpocetine	The serum concentration of Vinpocetine can be increased when it is combined with Fusidic Acid.	Investigational
Vismodegib	The serum concentration of Vismodegib can be increased when it is combined with Fusidic Acid.	Approved, Investigational
Voriconazole	The serum concentration of Voriconazole can be increased when it is combined with Fusidic Acid.	Approved, Investigational
Vortioxetine	The serum concentration of Vortioxetine can be increased when it is combined with Fusidic Acid.	Approved, Investigational
Voxilaprevir	The serum concentration of Voxilaprevir can be increased when it is combined with Fusidic Acid.	Approved, Investigational
Warfarin	The serum concentration of Warfarin can be increased when it is combined with Fusidic Acid.	Approved
WIN 55212-2	The serum concentration of WIN 55212-2 can be increased when it is combined with Fusidic Acid.	Experimental
Yohimbine	The serum concentration of Yohimbine can be increased when it is combined with Fusidic Acid.	Approved, Investigational, Vet Approved
Zafirlukast	The serum concentration of Zafirlukast can be increased when it is combined with Fusidic Acid.	Approved, Investigational
Zalcitabine	The serum concentration of Zalcitabine can be increased when it is combined with Fusidic Acid.	Approved, Investigational
Zaleplon	The serum concentration of Zaleplon can be increased when it is combined with Fusidic Acid.	Approved, Illicit, Investigational
Ziconotide	The serum concentration of Ziconotide can be increased when it is combined with Fusidic Acid.	Approved
Zidovudine	The serum concentration of Zidovudine can be increased when it is combined with Fusidic Acid.	Approved
Zileuton	The serum concentration of Zileuton can be increased when it is combined with Fusidic Acid.	Approved, Investigational, Withdrawn
Ziprasidone	The serum concentration of Ziprasidone can be increased when it is combined with Fusidic Acid.	Approved
Zolpidem	The serum concentration of Zolpidem can be increased when it is combined with Fusidic Acid.	Approved
Zomepirac	The serum concentration of Zomepirac can be increased when it is combined with Fusidic Acid.	Withdrawn
Zonisamide	The serum concentration of Zonisamide can be increased when it is combined with Fusidic Acid.	Approved, Investigational
Zopiclone	The serum concentration of Zopiclone can be increased when it is combined with Fusidic Acid.	Approved
Zotepine	The serum concentration of Zotepine can be increased when it is combined with Fusidic Acid.	Approved, Investigational, Withdrawn

Food Interactions

• Take with food to reduce irritation.

References

Synthesis Reference

Vanangamudi Subramaniam Sulur, Madhavan Srinivasan, Neelakandan Narayanan Chulliel, Haridas Sankar, Selvaraj Balkrishnan, " PROCESS TO MAKE FUSIDIC ACID CREAM." U.S. Patent US20110301138, issued December 08, 2011.

US20110301138

General References

Not Available

External Links

Human Metabolome Database

HMDB0015570

KEGG Drug

D04281

KEGG Compound

C06694

PubChem Compound

3000226

PubChem Substance

46505364

ChemSpider

2271900

BindingDB

58924

ChEBI

29013

ChEMBL

CHEMBL374975

Therapeutic Targets Database

DAP001008

PharmGKB

PA164749648

HET

FUA

Wikipedia

Fusidic_acid

ATC Codes

J01XC01 — Fusidic acid

• J01XC — Steroid antibacterials
• J01X — OTHER ANTIBACTERIALS
• J01 — ANTIBACTERIALS FOR SYSTEMIC USE
• J — ANTIINFECTIVES FOR SYSTEMIC USE

D06AX01 — Fusidic acid

• D06AX — Other antibiotics for topical use
• D06A — ANTIBIOTICS FOR TOPICAL USE
• D06 — ANTIBIOTICS AND CHEMOTHERAPEUTICS FOR DERMATOLOGICAL USE
• D — DERMATOLOGICALS

D09AA02 — Fusidic acid

• D09AA — Medicated dressings with antiinfectives
• D09A — MEDICATED DRESSINGS
• D09 — MEDICATED DRESSINGS
• D — DERMATOLOGICALS

S01AA13 — Fusidic acid

• S01AA — Antibiotics
• S01A — ANTIINFECTIVES
• S01 — OPHTHALMOLOGICALS
• S — SENSORY ORGANS

AHFS Codes

• 52:04.04 — Antibacterials
• 84:04.04 — Antibiotics
• 08:12.28.92 — Other Miscellaneous Antibacterial Agents*

PDB Entries

1q23 / 1qca / 2vuf / 4v5f / 4v5m / 4v5n / 4v7b / 4v8u / 4v9l / 4v9m …

show 2 more

Clinical Trials

Clinical Trials

Phase	Status	Purpose	Conditions	Count
2	Completed	Treatment	Skin Diseases, Bacterial	1
2	Terminated	Treatment	Infected Spacers / Prosthetic Joint Infections of Hip / Prosthetic Joint Infections of Knee	1
2, 3	Active Not Recruiting	Treatment	Refractory Bone or Joint Infections	1
3	Completed	Treatment	Lung Cancer Non-Small Cell Cancer (NSCLC)	1
3	Not Yet Recruiting	Treatment	Infected Atopic Dermatitis/Eczema	1
3	Unknown Status	Prevention	Hypertrophic Scars / Keloid Scars	1
4	Enrolling by Invitation	Treatment	Inflammation of the Eyelids	1
4	Terminated	Treatment	Impetigo	1
Not Available	Completed	Not Available	Impetigo	1
Not Available	Not Yet Recruiting	Treatment	Prosthetic Joint Infection	1
Not Available	Recruiting	Prevention	Motility Disorders / Staphylococcus Aureus	1

Pharmacoeconomics

Manufacturers

Not Available

Packagers

Not Available

Dosage forms

Form	Route	Strength
Cream	Topical	2 %
Tablet	Oral	250 mg
Cream	Topical
Dressing	Topical	2 %
Kit	Intravenous
Suspension	Oral	246 mg
Ointment	Topical	2 %
Solution / drops	Ophthalmic	1 %

Prices

Unit description	Cost	Unit
Fucidin 2 % Cream	0.66USD	g
Fucidin 2 % Ointment	0.66USD	g

DrugBank does not sell nor buy drugs. Pricing information is supplied for informational purposes only.

Patents

Not Available

Properties

State

Solid

Experimental Properties

Property	Value	Source
melting point (°C)	192.5 °C	PhysProp
pKa	5.35	MERCK INDEX (1996)

Predicted Properties

Property	Value	Source
Water Solubility	0.00521 mg/mL	ALOGPS
logP	4.97	ALOGPS
logP	4.42	ChemAxon
logS	-5	ALOGPS
pKa (Strongest Acidic)	4.66	ChemAxon
pKa (Strongest Basic)	-0.2	ChemAxon
Physiological Charge	-1	ChemAxon
Hydrogen Acceptor Count	5	ChemAxon
Hydrogen Donor Count	3	ChemAxon
Polar Surface Area	104.06 Å2	ChemAxon
Rotatable Bond Count	6	ChemAxon
Refractivity	144.12 m3·mol-1	ChemAxon
Polarizability	59.77 Å3	ChemAxon
Number of Rings	4	ChemAxon
Bioavailability	1	ChemAxon
Rule of Five	No	ChemAxon
Ghose Filter	No	ChemAxon
Veber's Rule	No	ChemAxon
MDDR-like Rule	Yes	ChemAxon

Predicted ADMET features

Property	Value	Probability
Human Intestinal Absorption	+	0.9691
Blood Brain Barrier	+	0.7909
Caco-2 permeable	-	0.6089
P-glycoprotein substrate	Substrate	0.8165
P-glycoprotein inhibitor I	Non-inhibitor	0.6004
P-glycoprotein inhibitor II	Inhibitor	0.7848
Renal organic cation transporter	Non-inhibitor	0.8424
CYP450 2C9 substrate	Non-substrate	0.8218
CYP450 2D6 substrate	Non-substrate	0.9349
CYP450 3A4 substrate	Substrate	0.798
CYP450 1A2 substrate	Non-inhibitor	0.9337
CYP450 2C9 inhibitor	Non-inhibitor	0.8834
CYP450 2D6 inhibitor	Non-inhibitor	0.9544
CYP450 2C19 inhibitor	Non-inhibitor	0.9347
CYP450 3A4 inhibitor	Non-inhibitor	0.76
CYP450 inhibitory promiscuity	Low CYP Inhibitory Promiscuity	0.819
Ames test	Non AMES toxic	0.8305
Carcinogenicity	Non-carcinogens	0.9508
Biodegradation	Not ready biodegradable	0.9753
Rat acute toxicity	3.5929 LD50, mol/kg	Not applicable
hERG inhibition (predictor I)	Weak inhibitor	0.9403
hERG inhibition (predictor II)	Non-inhibitor	0.7564

ADMET data is predicted using admetSAR, a free tool for evaluating chemical ADMET properties. (23092397)

Spectra

Mass Spec (NIST)

Not Available

Spectra

Spectrum	Spectrum Type	Splash Key
Predicted GC-MS Spectrum - GC-MS	Predicted GC-MS	Not Available
Predicted MS/MS Spectrum - 10V, Positive (Annotated)	Predicted LC-MS/MS	Not Available
Predicted MS/MS Spectrum - 20V, Positive (Annotated)	Predicted LC-MS/MS	Not Available
Predicted MS/MS Spectrum - 40V, Positive (Annotated)	Predicted LC-MS/MS	Not Available
Predicted MS/MS Spectrum - 10V, Negative (Annotated)	Predicted LC-MS/MS	Not Available
Predicted MS/MS Spectrum - 20V, Negative (Annotated)	Predicted LC-MS/MS	Not Available
Predicted MS/MS Spectrum - 40V, Negative (Annotated)	Predicted LC-MS/MS	Not Available
MS/MS Spectrum - Linear Ion Trap , negative	LC-MS/MS	splash10-05fr-0002900000-512150f35d55c73b9e09
MS/MS Spectrum - Linear Ion Trap , positive	LC-MS/MS	splash10-004i-0000900000-eecd35dcbd3fede944c2
MS/MS Spectrum - Linear Ion Trap , positive	LC-MS/MS	splash10-0002-0000900000-4a266f99ada066a14539

Taxonomy

Description

This compound belongs to the class of organic compounds known as steroid esters. These are compounds containing a steroid moiety which bears a carboxylic acid ester group.

Kingdom

Organic compounds

Super Class

Lipids and lipid-like molecules

Class

Steroids and steroid derivatives

Sub Class

Steroid esters

Direct Parent

Steroid esters

Alternative Parents

3-alpha-hydroxysteroids / 11-alpha-hydroxysteroids / Medium-chain fatty acids / Methyl-branched fatty acids / Hydroxy fatty acids / Unsaturated fatty acids / Dicarboxylic acids and derivatives / Secondary alcohols / Cyclic alcohols and derivatives / Carboxylic acid estersCarboxylic acids / Organic oxides / Hydrocarbon derivatives / Carbonyl compounds

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Substituents

Steroid ester / 3-hydroxysteroid / 3-alpha-hydroxysteroid / 11-hydroxysteroid / 11-alpha-hydroxysteroid / Hydroxysteroid / Medium-chain fatty acid / Branched fatty acid / Methyl-branched fatty acid / Hydroxy fatty acidFatty acyl / Fatty acid / Unsaturated fatty acid / Dicarboxylic acid or derivatives / Cyclic alcohol / Carboxylic acid ester / Secondary alcohol / Carboxylic acid / Carboxylic acid derivative / Hydrocarbon derivative / Organic oxygen compound / Carbonyl group / Organic oxide / Alcohol / Organooxygen compound / Aliphatic homopolycyclic compound

show 16 more

Molecular Framework

Aliphatic homopolycyclic compounds

External Descriptors

3alpha-hydroxy steroid, alpha,beta-unsaturated monocarboxylic acid, sterol ester, steroid acid, 11alpha-hydroxy steroid, steroid antibiotic (CHEBI:29013) / Prostostane and fusidane triterpenoids (LMPR0106040001)

Drug created on June 13, 2005 07:24 / Updated on August 15, 2018 09:52