Aminobenzoates

Name
Aminobenzoates
Accession Number
DBCAT000585
Description

Derivatives of BENZOIC ACID that contain one or more amino groups attached to the benzene ring structure. Included under this heading are a broad variety of acid forms, salts, esters, and amides that include the aminobenzoate structure.

Drugs
DrugDrug Description
Aminosalicylic acidAn aminosalicylate drug used to induce remission in ulcerative colitis.
Aminohippuric acidA hippuric acid derivative injection utilized in the measurement of effective renal plasma flow (ERPF) and functional capacity of the renal excretory system.
BentiromideIndicated as a screening test for exocrine pancreatic insufficiency and to monitor the adequacy of supplemental pancreatic therapy.
CisaprideA medication used to treat heartburn associated with GERD.
FurosemideA loop diuretic used to treat hypertension and edema in congestive heart failure, liver cirrhosis, renal disease, and hypertension.
ProcaineA local anesthetic used for anesthesia, peripheral nerve block, and spinal nerve block.
Mefenamic acidAn NSAID used to treat mild to moderate pain for no more than a week, and primary dysmenorrhea.
ProparacaineA topical anesthetic used for ophthalmic practice.
BumetanideA sulfamyl diuretic used to treat edema in congestive heart failure, hepatic and renal disease, and nephrotic syndrome.
OxybuprocaineA local anesthetic used in ophthalmology.
Meclofenamic acidAn NSAID used to treat mild to moderate pain, primary dysmenorrhea, heavy menstrual blood loss, rheumatoid arthritis, and osteoarthritis.
BalsalazideAn aminosalicylate used to treat ulcerative colitis.
ProcainamideA medication used to treat life threatening ventricular arrhythmias.
BenzocaineA topical local anesthetic used for the temporary relief of pain and itching associated with minor burns, sunburn, scrapes and insect bites or minor skin irritations.
ChloroprocaineA local anesthetic agent indicated for intrathecal injection in adults for the production of subarachnoid block, or spinal anesthesia.
MetoclopramideAn antiemetic agent and dopamine D2 antagonist used in the treatment of gastroesophageal reflux disease, prevention of nausea and vomiting, and to stimulate gastric emptying.
EmbutramideNot Available
Flufenamic acidAn anthranilic acid derivative with analgesic, anti-inflammatory, and antipyretic properties. It is used in musculoskeletal and joint disorders and administered by mouth and topically. (From Martindale, The Extra Pharmacopoeia, 30th...
Aminobenzoic acidA member of the vitamin B complex. It used to be common in sunscreening agents until found to also be a sensitizer. The potassium salt is used therapeutically in fibrotic...
Mant-AdpNot Available
3-hydroxyanthranilic acidAn oxidation product of tryptophan metabolism. It may be a free radical scavenger and a carcinogen.
Anthranilic acidNot Available
AcedobenNot Available
Niflumic acidUsed in the treatment of rheumatoid arthritis.
VX-765Investigated for use/treatment in inflammatory disorders (unspecified) and psoriasis and psoriatic disorders.
DeclopramideInvestigated for use/treatment in colorectal cancer and inflammatory bowel disease.
TranilastFor the treatment of bronchial asthma, keloid and hypertrophic scar, and allergic disorders such as asthma, allergic rhinitis and atopic dermatitis.
4-(Dimethylamino)benzoic acidNot Available
FloctafenineAn anti-inflammatory analgesic used to manage mild to moderate acute pain.
EtofenamateEtofenamate is used to treat muscle and joint paint. It is a non-steroidal anti-inflammatory drug (NSAID).
BromoprideBromopride in indicated in the treatment of nausea and vomiting, including PONV (post-operative nausea and vomiting), gastroesophageal reflux disease (GERD/GORD), as well as endoscopy preparation and radiographic studies of the...
TetracaineA local anaesthetic agent used to induce local analgesia in the eyes and skin during medical procedures.
Tolfenamic acidIn the information for tolfenamic acid, it is stated that this drug, being an NSAID, is effective in treating the pain associated with the acute attack of migraines in adults.
MorniflumateMorniflumate is indicated for the treatment of inflammatory conditions affecting the airways, ENT system, urogenital tract and bone and joint systems in adults. In Italy, morniflumate is also indicated for...
Procaine benzylpenicillinA local anesthetic and antibiotic combination for intramuscular injection to treat a variety of bacterial infections while reducing pain from a deep intramuscular injection.
PropoxycainePropoxycaine is a local anesthetic medication. It was used beginning in the 1950s during dental procedures . It has been combined with procaine to accelerate its onset of action and...
Acetrizoic acidAcetrizoic acid indication was to be used as a contrast agent for X-ray. Some information indicates its nephrotropic property as one of the characteristics for the utilization of acetrizoic acid....
MeradimateAn ingredient used in sunscreens to absorb UV radiation.
ButambenAnesthesia of mucus membranes other than the eyes.
Padimate APadimate A is an ester derivative of PABA and an ingredient in some sunscreens. It absorbs ultraviolet rays thereby preventing sunburn, however, its chemical structure and behaviour is similar to...
Padimate OAn ingredient used in sunscreens to absorb UV radiation.
IdasanutlinIdasanutlin has been used in trials studying the treatment of Neoplasms, Non-Hodgkin's Lymphoma, Leukemia, Myeloid, Acute, Recurrent Plasma Cell Myeloma, and Neoplasms, Leukemia, Acute Myeloid Leukemia.
CHF-6001CHF6001 has been used in trials studying the treatment of Asthma and Chronic Obstructive Pulmonary Disease.
AtaciguatAtaciguat has been investigated for the basic science of Aortic Valve Stenosis.
AminaphthoneAminaftone has been investigated for the treatment of Cockett Syndrome, May-Thurner Syndrome, and Iliac Vein Obstruction.
TicaloprideInvestigated for use/treatment in gastroesophageal reflux disease (GERD) and gastroparesis.
AZD-6482AZD-6482 is under investigation in clinical trial NCT00688714 (Study to Investigate Safety and Tolerability of a Single Dose of AZD6482).
Drugs & Drug Targets
DrugTargetType
Aminosalicylic acidGroup IIE secretory phospholipase A2target
Aminosalicylic acidProstaglandin G/H synthase 2target
Aminosalicylic acidArachidonate 5-lipoxygenasetarget
Aminosalicylic acidInhibitor of nuclear factor kappa-B kinase subunit alphatarget
Aminosalicylic acidMyeloperoxidaseenzyme
Aminohippuric acidSolute carrier family 22 member 2transporter
Aminohippuric acidSolute carrier family 22 member 5transporter
Aminohippuric acidSolute carrier family 22 member 6transporter
Aminohippuric acidSolute carrier family 22 member 8transporter
Aminohippuric acidCanalicular multispecific organic anion transporter 1transporter
Aminohippuric acidSolute carrier family 22 member 4transporter
Aminohippuric acidSolute carrier family 22 member 11transporter
Aminohippuric acidSolute carrier organic anion transporter family member 3A1transporter
Aminohippuric acidSolute carrier organic anion transporter family member 1B1transporter
Aminohippuric acidMultidrug resistance-associated protein 1transporter
Aminohippuric acidSolute carrier organic anion transporter family member 1A2transporter
Aminohippuric acidMonocarboxylate transporter 1transporter
Aminohippuric acidSolute carrier family 22 member 7transporter
BentiromideSerine protease hepsintarget
Cisapride5-hydroxytryptamine receptor 4target
Cisapride5-hydroxytryptamine receptor 3Atarget
CisapridePotassium voltage-gated channel subfamily H member 2target
Cisapride5-hydroxytryptamine receptor 2Atarget
CisaprideCytochrome P450 3A4enzyme
CisaprideCytochrome P450 3A5enzyme
CisaprideCytochrome P450 3A7enzyme
CisaprideCytochrome P450 2A6enzyme
CisaprideCytochrome P450 2B6enzyme
CisaprideCytochrome P450 2C19enzyme
CisaprideCytochrome P450 2C8enzyme
CisaprideCytochrome P450 2C9enzyme
CisaprideCytochrome P450 2D6enzyme
FurosemideSolute carrier family 12 member 1target
FurosemideSerum albumincarrier
FurosemideSolute carrier family 22 member 6transporter
FurosemideSolute carrier family 22 member 5transporter
FurosemideSolute carrier family 22 member 8transporter
FurosemideCanalicular multispecific organic anion transporter 1transporter
FurosemideSolute carrier organic anion transporter family member 2A1transporter
FurosemideSolute carrier family 22 member 11transporter
Furosemide6-phosphogluconate dehydrogenase, decarboxylatingenzyme
FurosemideCarbonic anhydrase 2target
FurosemideUDP-glucuronosyltransferase 1-1enzyme
FurosemideThyroxine-binding globulincarrier
FurosemideG-protein coupled receptor 35target
ProcaineSodium channel protein type 10 subunit alphatarget
ProcaineGlutamate receptor ionotropic, NMDA 3Atarget
Procaine5-hydroxytryptamine receptor 3Atarget
ProcaineSodium-dependent dopamine transportertarget
ProcaineNeuronal acetylcholine receptor subunit alpha-2target
ProcaineCholinesteraseenzyme
ProcaineDNA (cytosine-5)-methyltransferase 1target
ProcaineCalcium-activated potassium channeltarget
ProcaineCytosolic phospholipase A2target
Procaine60 kDa lysophospholipasetarget
ProcaineMonoamine oxidasetarget
ProcaineSodium-dependent dopamine transportertransporter
ProcaineSodium-dependent noradrenaline transportertransporter
ProcaineSodium-dependent serotonin transportertransporter
ProcaineDNA (cytosine-5)-methyltransferase 3Atarget
Mefenamic acidProstaglandin G/H synthase 2target
Mefenamic acidProstaglandin G/H synthase 1target
Mefenamic acidCytochrome P450 2C9enzyme
Mefenamic acidCytochrome P450 2C8enzyme
Mefenamic acidSerum albumincarrier
Mefenamic acidUDP-glucuronosyltransferase 1-9enzyme
ProparacaineSodium channel protein type 10 subunit alphatarget
BumetanideSolute carrier family 12 member 1target
BumetanideCystic fibrosis transmembrane conductance regulatortarget
BumetanideSolute carrier family 12 member 2target
BumetanideSolute carrier family 12 member 4target
BumetanideSolute carrier family 12 member 5target
BumetanideSodium/bile acid cotransportertransporter
BumetanideSolute carrier family 22 member 6transporter
BumetanideSolute carrier family 22 member 8transporter
BumetanideSolute carrier family 22 member 11transporter
BumetanideSolute carrier family 22 member 7transporter
BumetanideSolute carrier organic anion transporter family member 1A2transporter
BumetanideProstaglandin G/H synthase 2enzyme
OxybuprocaineSodium channel protein type 10 subunit alphatarget
OxybuprocaineCholinesteraseenzyme
Meclofenamic acidProstaglandin G/H synthase 1target
Meclofenamic acidProstaglandin G/H synthase 2target
Meclofenamic acidArachidonate 5-lipoxygenasetarget
Meclofenamic acidSolute carrier family 22 member 6transporter
Meclofenamic acidSolute carrier organic anion transporter family member 1C1transporter
Meclofenamic acidPotassium voltage-gated channel subfamily KQT member 2target
Meclofenamic acidPotassium voltage-gated channel subfamily KQT member 3target
Meclofenamic acidThyroxine-binding globulincarrier
BalsalazideProstaglandin G/H synthase 1target
BalsalazideProstaglandin G/H synthase 2target
BalsalazideArachidonate 5-lipoxygenasetarget
BalsalazidePeroxisome proliferator-activated receptor gammatarget
BalsalazideNADPH azoreductaseenzyme
ProcainamideSodium channel protein type 5 subunit alphatarget
ProcainamideDNA (cytosine-5)-methyltransferase 1target
ProcainamideCytochrome P450 2D6enzyme
ProcainamideCholinesteraseenzyme
ProcainamideSolute carrier family 22 member 2transporter
ProcainamideSolute carrier family 22 member 1transporter
ProcainamideSolute carrier family 22 member 3transporter
ProcainamideSolute carrier family 22 member 5transporter
ProcainamideSolute carrier family 22 member 4transporter
ProcainamidePotassium voltage-gated channel subfamily H member 2target
ProcainamideMultidrug and toxin extrusion protein 1transporter
ProcainamideMultidrug and toxin extrusion protein 2transporter
BenzocaineSodium channel protein type 10 subunit alphatarget
BenzocaineP-glycoprotein 1transporter
BenzocaineLiver carboxylesterase 1enzyme
ChloroprocaineSodium channel protein type 10 subunit alphatarget
ChloroprocaineSodium-dependent dopamine transportertarget
ChloroprocaineCholinesteraseenzyme
MetoclopramideMuscarinic acetylcholine receptor M1target
MetoclopramideDopamine D2 receptortarget
MetoclopramideCytochrome P450 2D6enzyme
Metoclopramide5-hydroxytryptamine receptor 4target
Metoclopramide5-hydroxytryptamine receptor 3Atarget
MetoclopramideCytochrome P450 3A4enzyme
MetoclopramideCytochrome P450 1A2enzyme
MetoclopramideP-glycoprotein 1transporter
MetoclopramideAlpha-1-acid glycoprotein 1carrier
Flufenamic acidAldo-keto reductase family 1 member C3target
Flufenamic acidTransthyretincarrier
Flufenamic acidProstaglandin G/H synthase 2target
Flufenamic acidProstaglandin G/H synthase 1target
Flufenamic acidSolute carrier family 22 member 6transporter
Flufenamic acidAndrogen receptortarget
Flufenamic acidPeroxisome proliferator-activated receptor alphatarget
Flufenamic acidPeroxisome proliferator-activated receptor gammatarget
Aminobenzoic acidp-hydroxybenzoate hydroxylasetarget
Mant-AdpMyosin-14target
3-hydroxyanthranilic acidTrans-2,3-dihydro-3-hydroxyanthranilate isomerasetarget
Anthranilic acidL-amino-acid oxidasetarget
Anthranilic acidD-amino-acid oxidasetarget
Niflumic acidPhospholipase A2target
Niflumic acidChloride channel protein ClC-Katarget
Niflumic acidMonocarboxylate transporter 2transporter
Niflumic acidMonocarboxylate transporter 1transporter
Niflumic acidProstaglandin G/H synthase 2target
Niflumic acidProstaglandin G/H synthase 1target
Niflumic acidCytosolic phospholipase A2target
Niflumic acidUDP-glucuronosyltransferase 1-9target
Niflumic acidUDP-glucuronosyltransferase 1-9enzyme
VX-765Caspase-1target
VX-765Interleukin-1 betatarget
DeclopramideDNAtarget
DeclopramideDNA topoisomerase 2-alphatarget
DeclopramideDNA topoisomerase 2-betatarget
TranilastHematopoietic prostaglandin D synthasetarget
TranilastCytochrome P450 3A4enzyme
TranilastCytochrome P450 2C9enzyme
4-(Dimethylamino)benzoic acidReplicase polyprotein 1abtarget
4-(Dimethylamino)benzoic acidOrf1a polyproteintarget
EtofenamateThyroxine-binding globulincarrier
BromoprideDopamine D2 receptortarget
TetracaineRyanodine receptor 1target
TetracaineRyanodine receptor 2target
TetracaineVoltage-gated sodium channel alpha subunittarget
Tolfenamic acidProstaglandin G/H synthase 1target
Tolfenamic acidProstaglandin G/H synthase 2target
Tolfenamic acidCytochrome P450 3A4enzyme
MorniflumateArachidonate 5-lipoxygenasetarget
MorniflumateProstaglandin G/H synthase 2target
MorniflumateArachidonate 5-lipoxygenaseenzyme
MorniflumateProstaglandin G/H synthase 2enzyme
MorniflumateLeukotriene B4 receptor 1target
MorniflumateThromboxane A2 receptortarget
MorniflumateUDP-glucuronosyltransferase 1-9enzyme
PropoxycaineLiver carboxylesterase 1enzyme
PropoxycaineVoltage-gated sodium channel alpha subunittarget
Acetrizoic acidSerum albumincarrier
ButambenVoltage-dependent calcium channeltarget
ButambenCholinesteraseenzyme
ButambenAlpha-1-acid glycoprotein 1carrier
ButambenSerum albumincarrier
ButambenATP-sensitive potassium channeltarget
ButambenTransient receptor potential cation channel subfamily A member 1target
ButambenTransient receptor potential cation channel subfamily V member 4target
Ticalopride5-hydroxytryptamine receptor 4target
Ticalopride5-hydroxytryptamine receptor 3Atarget