Floctafenine

Identification

Name
Floctafenine
Accession Number
DB08976
Type
Small Molecule
Groups
Approved, Withdrawn
Description

Floctafenine is an anti-inflammatory analgesic similar in action to aspirin. Floctafenine inhibits prostaglandin synthesis.

Structure
Thumb
Synonyms
Not Available
External IDs
R 4318 / R-4138 / R-4318 / RU 15750
Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
FloctafenineTablet200 mgOralAa Pharma Inc2001-11-14Not applicableCanada
FloctafenineTablet400 mgOralAa Pharma Inc2001-11-14Not applicableCanada
IdaracTablet400 mgOralSanofi Synthelabo1988-12-312004-08-05Canada
IdaracTablet200 mgOralSanofi Synthelabo1985-12-312004-08-05Canada
International/Other Brands
Diralgan / Idalon / Novodolan
Categories
UNII
9YH7975LEF
CAS number
23779-99-9
Weight
Average: 406.361
Monoisotopic: 406.114041524
Chemical Formula
C20H17F3N2O4
InChI Key
APQPGQGAWABJLN-GFCCVEGCSA-N
InChI
InChI=1S/C20H17F3N2O4/c21-20(22,23)15-6-3-5-13-17(8-9-24-18(13)15)25-16-7-2-1-4-14(16)19(28)29-11-12(27)10-26/h1-9,12,26-27H,10-11H2,(H,24,25)/t12-/m1/s1
IUPAC Name
(2R)-2,3-dihydroxypropyl 2-{[8-(trifluoromethyl)quinolin-4-yl]amino}benzoate
SMILES
OC[C@@H](O)COC(=O)C1=C(NC2=C3C=CC=C(C3=NC=C2)C(F)(F)F)C=CC=C1

Pharmacology

Indication
Not Available
Associated Conditions
Pharmacodynamics
Not Available
Mechanism of action
Not Available
Absorption
Not Available
Volume of distribution
Not Available
Protein binding
Not Available
Metabolism
Not Available
Route of elimination
Not Available
Half life
Not Available
Clearance
Not Available
Toxicity
Not Available
Affected organisms
Not Available
Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
DrugInteractionDrug group
(4R)-limoneneThe risk or severity of adverse effects can be increased when Floctafenine is combined with (4R)-limonene.Investigational
16-BromoepiandrosteroneThe risk or severity of adverse effects can be increased when Floctafenine is combined with 16-Bromoepiandrosterone.Investigational
19-norandrostenedioneThe risk or severity of adverse effects can be increased when Floctafenine is combined with 19-norandrostenedione.Experimental, Illicit
5-androstenedioneThe risk or severity of adverse effects can be increased when Floctafenine is combined with 5-androstenedione.Experimental, Illicit
AbciximabFloctafenine may increase the anticoagulant activities of Abciximab.Approved
AcebutololThe risk or severity of adverse effects can be increased when Acebutolol is combined with Floctafenine.Approved, Investigational
AceclofenacThe risk or severity of adverse effects can be increased when Floctafenine is combined with Aceclofenac.Approved, Investigational
AcemetacinThe risk or severity of adverse effects can be increased when Floctafenine is combined with Acemetacin.Approved, Experimental, Investigational
AcenocoumarolFloctafenine may increase the anticoagulant activities of Acenocoumarol.Approved, Investigational
AcetaminophenThe risk or severity of adverse effects can be increased when Floctafenine is combined with Acetaminophen.Approved
Acetylsalicylic acidThe risk or severity of adverse effects can be increased when Floctafenine is combined with Acetylsalicylic acid.Approved, Vet Approved
AdapaleneThe risk or severity of adverse effects can be increased when Floctafenine is combined with Adapalene.Approved
AlclofenacThe risk or severity of adverse effects can be increased when Floctafenine is combined with Alclofenac.Approved, Withdrawn
AlclometasoneThe risk or severity of adverse effects can be increased when Floctafenine is combined with Alclometasone.Approved
AldosteroneThe risk or severity of adverse effects can be increased when Floctafenine is combined with Aldosterone.Experimental, Investigational
Alendronic acidThe risk or severity of adverse effects can be increased when Floctafenine is combined with Alendronic acid.Approved
AliskirenFloctafenine may decrease the antihypertensive activities of Aliskiren.Approved, Investigational
AlminoprofenThe risk or severity of adverse effects can be increased when Floctafenine is combined with Alminoprofen.Experimental
AlprenololThe risk or severity of adverse effects can be increased when Alprenolol is combined with Floctafenine.Approved, Withdrawn
AlprostadilThe therapeutic efficacy of Alprostadil can be decreased when used in combination with Floctafenine.Approved, Investigational
AmcinonideThe risk or severity of adverse effects can be increased when Floctafenine is combined with Amcinonide.Approved
AmikacinFloctafenine may decrease the excretion rate of Amikacin which could result in a higher serum level.Approved, Investigational, Vet Approved
AmilorideFloctafenine may decrease the antihypertensive activities of Amiloride.Approved
Aminosalicylic AcidThe risk or severity of adverse effects can be increased when Floctafenine is combined with Aminosalicylic Acid.Approved
AmiodaroneThe risk or severity of adverse effects can be increased when Amiodarone is combined with Floctafenine.Approved, Investigational
AncrodFloctafenine may increase the anticoagulant activities of Ancrod.Approved, Investigational
AndrographolideThe risk or severity of adverse effects can be increased when Floctafenine is combined with Andrographolide.Investigational
AndrostenedioneThe risk or severity of adverse effects can be increased when Floctafenine is combined with Androstenedione.Experimental, Illicit
AnecortaveThe risk or severity of adverse effects can be increased when Floctafenine is combined with Anecortave.Investigational
anecortave acetateThe risk or severity of adverse effects can be increased when Floctafenine is combined with anecortave acetate.Investigational
AnisodamineThe risk or severity of adverse effects can be increased when Floctafenine is combined with Anisodamine.Investigational
AntipyrineThe risk or severity of adverse effects can be increased when Floctafenine is combined with Antipyrine.Approved, Investigational
Antithrombin III humanFloctafenine may increase the anticoagulant activities of Antithrombin III human.Approved
AntrafenineThe risk or severity of adverse effects can be increased when Floctafenine is combined with Antrafenine.Approved
ApixabanFloctafenine may increase the anticoagulant activities of Apixaban.Approved
ApocyninThe risk or severity of adverse effects can be increased when Floctafenine is combined with Apocynin.Investigational
ApramycinFloctafenine may decrease the excretion rate of Apramycin which could result in a higher serum level.Experimental, Vet Approved
ApremilastThe risk or severity of adverse effects can be increased when Floctafenine is combined with Apremilast.Approved, Investigational
ArbekacinFloctafenine may decrease the excretion rate of Arbekacin which could result in a higher serum level.Approved, Investigational
ArdeparinFloctafenine may increase the anticoagulant activities of Ardeparin.Approved, Investigational, Withdrawn
ArgatrobanFloctafenine may increase the anticoagulant activities of Argatroban.Approved, Investigational
ArotinololThe risk or severity of adverse effects can be increased when Arotinolol is combined with Floctafenine.Investigational
AsenapineThe risk or severity of adverse effects can be increased when Asenapine is combined with Floctafenine.Approved
AtamestaneThe risk or severity of adverse effects can be increased when Floctafenine is combined with Atamestane.Investigational
AtenololThe risk or severity of adverse effects can be increased when Atenolol is combined with Floctafenine.Approved
AzapropazoneThe risk or severity of adverse effects can be increased when Floctafenine is combined with Azapropazone.Withdrawn
AzelastineThe risk or severity of adverse effects can be increased when Floctafenine is combined with Azelastine.Approved
Azficel-TThe risk or severity of adverse effects can be increased when Floctafenine is combined with Azficel-T.Approved, Investigational
Azilsartan medoxomilThe risk or severity of adverse effects can be increased when Azilsartan medoxomil is combined with Floctafenine.Approved, Investigational
AzosemideThe therapeutic efficacy of Azosemide can be decreased when used in combination with Floctafenine.Investigational
BalsalazideThe risk or severity of adverse effects can be increased when Floctafenine is combined with Balsalazide.Approved, Investigational
BecaplerminFloctafenine may increase the anticoagulant activities of Becaplermin.Approved, Investigational
Beclomethasone dipropionateThe risk or severity of adverse effects can be increased when Floctafenine is combined with Beclomethasone dipropionate.Approved, Investigational
BefunololThe risk or severity of adverse effects can be increased when Befunolol is combined with Floctafenine.Experimental
BekanamycinFloctafenine may decrease the excretion rate of Bekanamycin which could result in a higher serum level.Experimental
BenazeprilThe risk or severity of adverse effects can be increased when Floctafenine is combined with Benazepril.Approved, Investigational
BendazacThe risk or severity of adverse effects can be increased when Floctafenine is combined with Bendazac.Experimental
BendroflumethiazideThe therapeutic efficacy of Bendroflumethiazide can be decreased when used in combination with Floctafenine.Approved
BenorilateThe risk or severity of adverse effects can be increased when Floctafenine is combined with Benorilate.Experimental
BenoxaprofenThe risk or severity of adverse effects can be increased when Floctafenine is combined with Benoxaprofen.Withdrawn
BenzthiazideThe therapeutic efficacy of Benzthiazide can be decreased when used in combination with Floctafenine.Approved
BenzydamineThe risk or severity of adverse effects can be increased when Floctafenine is combined with Benzydamine.Approved
BeraprostThe therapeutic efficacy of Beraprost can be decreased when used in combination with Floctafenine.Investigational
BetamethasoneThe risk or severity of adverse effects can be increased when Floctafenine is combined with Betamethasone.Approved, Vet Approved
BetaxololThe risk or severity of adverse effects can be increased when Betaxolol is combined with Floctafenine.Approved, Investigational
BetrixabanThe risk or severity of bleeding can be increased when Betrixaban is combined with Floctafenine.Approved, Investigational
BevantololThe risk or severity of adverse effects can be increased when Bevantolol is combined with Floctafenine.Approved
BevoniumThe risk or severity of adverse effects can be increased when Floctafenine is combined with Bevonium.Experimental
BimatoprostThe therapeutic efficacy of Bimatoprost can be decreased when used in combination with Floctafenine.Approved, Investigational
BisoprololThe risk or severity of adverse effects can be increased when Bisoprolol is combined with Floctafenine.Approved
BivalirudinFloctafenine may increase the anticoagulant activities of Bivalirudin.Approved, Investigational
BopindololThe risk or severity of adverse effects can be increased when Bopindolol is combined with Floctafenine.Approved
BromfenacThe risk or severity of adverse effects can be increased when Floctafenine is combined with Bromfenac.Approved
BucillamineThe risk or severity of adverse effects can be increased when Floctafenine is combined with Bucillamine.Investigational
BucindololThe risk or severity of adverse effects can be increased when Bucindolol is combined with Floctafenine.Investigational
BudesonideThe risk or severity of adverse effects can be increased when Floctafenine is combined with Budesonide.Approved
BufexamacThe risk or severity of adverse effects can be increased when Floctafenine is combined with Bufexamac.Approved, Experimental
BufuralolThe risk or severity of adverse effects can be increased when Bufuralol is combined with Floctafenine.Experimental, Investigational
BumadizoneThe risk or severity of adverse effects can be increased when Floctafenine is combined with Bumadizone.Experimental
BumetanideThe therapeutic efficacy of Bumetanide can be decreased when used in combination with Floctafenine.Approved
BupranololThe risk or severity of adverse effects can be increased when Bupranolol is combined with Floctafenine.Approved
CandesartanThe risk or severity of adverse effects can be increased when Candesartan is combined with Floctafenine.Experimental
Candesartan cilexetilThe risk or severity of adverse effects can be increased when Candesartan cilexetil is combined with Floctafenine.Approved
CandoxatrilThe risk or severity of adverse effects can be increased when Floctafenine is combined with Candoxatril.Experimental
CapsaicinThe risk or severity of adverse effects can be increased when Floctafenine is combined with Capsaicin.Approved
CaptoprilThe risk or severity of adverse effects can be increased when Floctafenine is combined with Captopril.Approved
Carbaspirin calciumThe risk or severity of adverse effects can be increased when Floctafenine is combined with Carbaspirin calcium.Experimental, Investigational
Carboprost TromethamineThe therapeutic efficacy of Carboprost Tromethamine can be decreased when used in combination with Floctafenine.Approved
CarprofenThe risk or severity of adverse effects can be increased when Floctafenine is combined with Carprofen.Approved, Vet Approved, Withdrawn
CarteololThe risk or severity of adverse effects can be increased when Carteolol is combined with Floctafenine.Approved
CarvedilolThe risk or severity of adverse effects can be increased when Carvedilol is combined with Floctafenine.Approved, Investigational
CastanospermineThe risk or severity of adverse effects can be increased when Floctafenine is combined with Castanospermine.Experimental
CelecoxibThe risk or severity of adverse effects can be increased when Floctafenine is combined with Celecoxib.Approved, Investigational
CeliprololThe risk or severity of adverse effects can be increased when Celiprolol is combined with Floctafenine.Approved, Investigational
CertoparinFloctafenine may increase the anticoagulant activities of Certoparin.Approved, Investigational
ChloroquineThe risk or severity of adverse effects can be increased when Floctafenine is combined with Chloroquine.Approved, Investigational, Vet Approved
ChlorothiazideThe therapeutic efficacy of Chlorothiazide can be decreased when used in combination with Floctafenine.Approved, Vet Approved
ChlorphenesinThe risk or severity of adverse effects can be increased when Floctafenine is combined with Chlorphenesin.Approved, Vet Approved, Withdrawn
ChlorthalidoneThe therapeutic efficacy of Chlorthalidone can be decreased when used in combination with Floctafenine.Approved
CholestyramineCholestyramine can cause a decrease in the absorption of Floctafenine resulting in a reduced serum concentration and potentially a decrease in efficacy.Approved, Investigational
Choline magnesium trisalicylateThe risk or severity of adverse effects can be increased when Floctafenine is combined with Choline magnesium trisalicylate.Approved
CiclesonideThe risk or severity of adverse effects can be increased when Floctafenine is combined with Ciclesonide.Approved, Investigational
CilazaprilThe risk or severity of adverse effects can be increased when Floctafenine is combined with Cilazapril.Approved
CimicoxibThe risk or severity of adverse effects can be increased when Floctafenine is combined with Cimicoxib.Investigational
CinoxacinFloctafenine may increase the neuroexcitatory activities of Cinoxacin.Approved, Investigational, Withdrawn
CiprofloxacinFloctafenine may increase the neuroexcitatory activities of Ciprofloxacin.Approved, Investigational
CisplatinThe risk or severity of adverse effects can be increased when Floctafenine is combined with Cisplatin.Approved
Citric AcidFloctafenine may increase the anticoagulant activities of Citric Acid.Approved, Nutraceutical, Vet Approved
ClobetasolThe risk or severity of adverse effects can be increased when Floctafenine is combined with Clobetasol.Approved, Investigational
Clobetasol propionateThe risk or severity of adverse effects can be increased when Floctafenine is combined with Clobetasol propionate.Approved
ClobetasoneThe risk or severity of adverse effects can be increased when Floctafenine is combined with Clobetasone.Approved
ClocortoloneThe risk or severity of adverse effects can be increased when Floctafenine is combined with Clocortolone.Approved
Clodronic AcidThe risk or severity of adverse effects can be increased when Floctafenine is combined with Clodronic Acid.Approved, Investigational, Vet Approved
ClonixinThe risk or severity of adverse effects can be increased when Floctafenine is combined with Clonixin.Approved
CloprostenolThe therapeutic efficacy of Cloprostenol can be decreased when used in combination with Floctafenine.Vet Approved
CloranololThe risk or severity of adverse effects can be increased when Cloranolol is combined with Floctafenine.Experimental
ColesevelamColesevelam can cause a decrease in the absorption of Floctafenine resulting in a reduced serum concentration and potentially a decrease in efficacy.Approved
ColestipolColestipol can cause a decrease in the absorption of Floctafenine resulting in a reduced serum concentration and potentially a decrease in efficacy.Approved
Cortexolone 17α-propionateThe risk or severity of adverse effects can be increased when Floctafenine is combined with Cortexolone 17α-propionate.Investigational
CorticosteroneThe risk or severity of adverse effects can be increased when Floctafenine is combined with Corticosterone.Experimental
Cortisone acetateThe risk or severity of adverse effects can be increased when Floctafenine is combined with Cortisone acetate.Approved, Investigational
CurcuminThe risk or severity of adverse effects can be increased when Floctafenine is combined with Curcumin.Approved, Investigational
CyclopenthiazideThe therapeutic efficacy of Cyclopenthiazide can be decreased when used in combination with Floctafenine.Experimental
CyclosporineFloctafenine may increase the nephrotoxic activities of Cyclosporine.Approved, Investigational, Vet Approved
Dabigatran etexilateFloctafenine may increase the anticoagulant activities of Dabigatran etexilate.Approved
DalteparinFloctafenine may increase the anticoagulant activities of Dalteparin.Approved
DanaparoidFloctafenine may increase the anticoagulant activities of Danaparoid.Approved, Withdrawn
DarexabanFloctafenine may increase the anticoagulant activities of Darexaban.Investigational
DeferasiroxThe risk or severity of adverse effects can be increased when Floctafenine is combined with Deferasirox.Approved, Investigational
DeflazacortThe risk or severity of adverse effects can be increased when Floctafenine is combined with Deflazacort.Approved, Investigational
DelaprilThe risk or severity of adverse effects can be increased when Floctafenine is combined with Delapril.Experimental
DesipramineThe risk or severity of adverse effects can be increased when Desipramine is combined with Floctafenine.Approved, Investigational
DesirudinFloctafenine may increase the anticoagulant activities of Desirudin.Approved
DesmopressinThe risk or severity of adverse effects can be increased when Floctafenine is combined with Desmopressin.Approved
DesonideThe risk or severity of adverse effects can be increased when Floctafenine is combined with Desonide.Approved, Investigational
DesoximetasoneThe risk or severity of adverse effects can be increased when Floctafenine is combined with Desoximetasone.Approved
Desoxycorticosterone acetateThe risk or severity of adverse effects can be increased when Floctafenine is combined with Desoxycorticosterone acetate.Approved
Desoxycorticosterone PivalateThe risk or severity of adverse effects can be increased when Floctafenine is combined with Desoxycorticosterone Pivalate.Experimental, Vet Approved
DexamethasoneThe risk or severity of adverse effects can be increased when Floctafenine is combined with Dexamethasone.Approved, Investigational, Vet Approved
Dexamethasone isonicotinateThe risk or severity of adverse effects can be increased when Floctafenine is combined with Dexamethasone isonicotinate.Vet Approved
DexibuprofenThe risk or severity of adverse effects can be increased when Floctafenine is combined with Dexibuprofen.Approved, Investigational
DexketoprofenThe risk or severity of adverse effects can be increased when Dexketoprofen is combined with Floctafenine.Approved, Investigational
DextranFloctafenine may increase the anticoagulant activities of Dextran.Approved, Investigational, Vet Approved
DibekacinFloctafenine may decrease the excretion rate of Dibekacin which could result in a higher serum level.Experimental
Dibotermin alfaThe risk or severity of adverse effects can be increased when Floctafenine is combined with Dibotermin alfa.Approved, Investigational
DiclofenacThe risk or severity of adverse effects can be increased when Floctafenine is combined with Diclofenac.Approved, Vet Approved
DicoumarolFloctafenine may increase the anticoagulant activities of Dicoumarol.Approved
DifenpiramideThe risk or severity of adverse effects can be increased when Floctafenine is combined with Difenpiramide.Experimental
DiflorasoneThe risk or severity of adverse effects can be increased when Floctafenine is combined with Diflorasone.Approved
DiflunisalThe risk or severity of adverse effects can be increased when Floctafenine is combined with Diflunisal.Approved, Investigational
DifluocortoloneThe risk or severity of adverse effects can be increased when Floctafenine is combined with Difluocortolone.Approved, Investigational, Withdrawn
DifluprednateThe risk or severity of adverse effects can be increased when Floctafenine is combined with Difluprednate.Approved
DigoxinThe serum concentration of Digoxin can be increased when it is combined with Floctafenine.Approved
DihydrostreptomycinFloctafenine may decrease the excretion rate of Dihydrostreptomycin which could result in a higher serum level.Investigational, Vet Approved
DinoprostThe therapeutic efficacy of Dinoprost can be decreased when used in combination with Floctafenine.Investigational
Dinoprost TromethamineThe therapeutic efficacy of Dinoprost Tromethamine can be decreased when used in combination with Floctafenine.Approved, Vet Approved
DinoprostoneThe therapeutic efficacy of Dinoprostone can be decreased when used in combination with Floctafenine.Approved
DrospirenoneFloctafenine may increase the hyperkalemic activities of Drospirenone.Approved
DroxicamThe risk or severity of adverse effects can be increased when Floctafenine is combined with Droxicam.Withdrawn
DuvelisibThe risk or severity of adverse effects can be increased when Floctafenine is combined with Duvelisib.Investigational
E-6201The risk or severity of adverse effects can be increased when Floctafenine is combined with E-6201.Investigational
Edetic AcidFloctafenine may increase the anticoagulant activities of Edetic Acid.Approved, Vet Approved
EdoxabanFloctafenine may increase the anticoagulant activities of Edoxaban.Approved
EnalaprilThe risk or severity of adverse effects can be increased when Floctafenine is combined with Enalapril.Approved, Vet Approved
EnalaprilatThe risk or severity of adverse effects can be increased when Floctafenine is combined with Enalaprilat.Approved
EnoxacinFloctafenine may increase the neuroexcitatory activities of Enoxacin.Approved, Investigational
EnoxaparinFloctafenine may increase the anticoagulant activities of Enoxaparin.Approved
EnprostilThe therapeutic efficacy of Enprostil can be decreased when used in combination with Floctafenine.Experimental
EpanololThe risk or severity of adverse effects can be increased when Epanolol is combined with Floctafenine.Experimental
EpirizoleThe risk or severity of adverse effects can be increased when Floctafenine is combined with Epirizole.Approved
EpitizideThe therapeutic efficacy of Epitizide can be decreased when used in combination with Floctafenine.Experimental
EplerenoneFloctafenine may decrease the antihypertensive activities of Eplerenone.Approved
EpoprostenolThe therapeutic efficacy of Epoprostenol can be decreased when used in combination with Floctafenine.Approved
EprosartanThe risk or severity of adverse effects can be increased when Eprosartan is combined with Floctafenine.Approved
EquileninThe risk or severity of adverse effects can be increased when Floctafenine is combined with Equilenin.Experimental
EquilinThe risk or severity of adverse effects can be increased when Floctafenine is combined with Equilin.Approved
EsatenololThe risk or severity of adverse effects can be increased when Esatenolol is combined with Floctafenine.Experimental
EsmololThe risk or severity of adverse effects can be increased when Esmolol is combined with Floctafenine.Approved
EstroneThe risk or severity of adverse effects can be increased when Floctafenine is combined with Estrone.Approved
Estrone sulfateThe risk or severity of adverse effects can be increased when Floctafenine is combined with Estrone sulfate.Approved
Etacrynic acidThe therapeutic efficacy of Etacrynic acid can be decreased when used in combination with Floctafenine.Approved, Investigational
EtanerceptThe risk or severity of adverse effects can be increased when Floctafenine is combined with Etanercept.Approved, Investigational
EthenzamideThe risk or severity of adverse effects can be increased when Floctafenine is combined with Ethenzamide.Experimental
Ethyl biscoumacetateFloctafenine may increase the anticoagulant activities of Ethyl biscoumacetate.Withdrawn
Etidronic acidThe risk or severity of adverse effects can be increased when Floctafenine is combined with Etidronic acid.Approved
EtodolacThe risk or severity of adverse effects can be increased when Floctafenine is combined with Etodolac.Approved, Investigational, Vet Approved
EtofenamateThe risk or severity of adverse effects can be increased when Floctafenine is combined with Etofenamate.Approved, Investigational
EtoricoxibThe risk or severity of adverse effects can be increased when Floctafenine is combined with Etoricoxib.Approved, Investigational
Evening primrose oilThe risk or severity of adverse effects can be increased when Floctafenine is combined with Evening primrose oil.Investigational, Nutraceutical
ExisulindThe risk or severity of adverse effects can be increased when Floctafenine is combined with Exisulind.Investigational
FelbinacThe risk or severity of adverse effects can be increased when Floctafenine is combined with Felbinac.Experimental
FenbufenThe risk or severity of adverse effects can be increased when Floctafenine is combined with Fenbufen.Approved
FenoprofenThe risk or severity of adverse effects can be increased when Floctafenine is combined with Fenoprofen.Approved
FenprostaleneThe therapeutic efficacy of Fenprostalene can be decreased when used in combination with Floctafenine.Vet Approved
FentiazacThe risk or severity of adverse effects can be increased when Floctafenine is combined with Fentiazac.Experimental
FeprazoneThe risk or severity of adverse effects can be increased when Floctafenine is combined with Feprazone.Experimental
Ferulic acidThe risk or severity of adverse effects can be increased when Floctafenine is combined with Ferulic acid.Experimental
FimasartanThe risk or severity of adverse effects can be increased when Fimasartan is combined with Floctafenine.Approved, Investigational
Fish oilThe risk or severity of adverse effects can be increased when Floctafenine is combined with Fish oil.Approved, Nutraceutical
FleroxacinFloctafenine may increase the neuroexcitatory activities of Fleroxacin.Approved
FluasteroneThe risk or severity of adverse effects can be increased when Floctafenine is combined with Fluasterone.Investigational
FludrocortisoneThe risk or severity of adverse effects can be increased when Floctafenine is combined with Fludrocortisone.Approved, Investigational
FluindioneFloctafenine may increase the anticoagulant activities of Fluindione.Approved, Investigational
FlumequineFloctafenine may increase the neuroexcitatory activities of Flumequine.Withdrawn
FlumethasoneThe risk or severity of adverse effects can be increased when Floctafenine is combined with Flumethasone.Approved, Vet Approved
FlunisolideThe risk or severity of adverse effects can be increased when Floctafenine is combined with Flunisolide.Approved, Investigational
FlunixinThe risk or severity of adverse effects can be increased when Floctafenine is combined with Flunixin.Vet Approved
FlunoxaprofenThe risk or severity of adverse effects can be increased when Floctafenine is combined with Flunoxaprofen.Experimental
Fluocinolone AcetonideThe risk or severity of adverse effects can be increased when Floctafenine is combined with Fluocinolone Acetonide.Approved, Investigational, Vet Approved
FluocinonideThe risk or severity of adverse effects can be increased when Floctafenine is combined with Fluocinonide.Approved, Investigational
FluocortoloneThe risk or severity of adverse effects can be increased when Floctafenine is combined with Fluocortolone.Approved, Withdrawn
FluorometholoneThe risk or severity of adverse effects can be increased when Floctafenine is combined with Fluorometholone.Approved, Investigational
FluprednideneThe risk or severity of adverse effects can be increased when Floctafenine is combined with Fluprednidene.Approved, Withdrawn
FluprednisoloneThe risk or severity of adverse effects can be increased when Floctafenine is combined with Fluprednisolone.Approved
FluprostenolThe therapeutic efficacy of Fluprostenol can be decreased when used in combination with Floctafenine.Vet Approved
FlurandrenolideThe risk or severity of adverse effects can be increased when Floctafenine is combined with Flurandrenolide.Approved
FlurbiprofenThe risk or severity of adverse effects can be increased when Floctafenine is combined with Flurbiprofen.Approved, Investigational
FluticasoneThe risk or severity of adverse effects can be increased when Floctafenine is combined with Fluticasone.Approved, Experimental, Investigational
Fluticasone furoateThe risk or severity of adverse effects can be increased when Floctafenine is combined with Fluticasone furoate.Approved
Fluticasone propionateThe risk or severity of adverse effects can be increased when Floctafenine is combined with Fluticasone propionate.Approved
Folic AcidThe therapeutic efficacy of Folic Acid can be decreased when used in combination with Floctafenine.Approved, Nutraceutical, Vet Approved
FondaparinuxFloctafenine may increase the anticoagulant activities of Fondaparinux.Approved, Investigational
Fondaparinux sodiumFloctafenine may increase the anticoagulant activities of Fondaparinux sodium.Approved, Investigational
ForasartanThe risk or severity of adverse effects can be increased when Forasartan is combined with Floctafenine.Experimental
FormestaneThe risk or severity of adverse effects can be increased when Floctafenine is combined with Formestane.Approved, Investigational, Withdrawn
FosinoprilThe risk or severity of adverse effects can be increased when Floctafenine is combined with Fosinopril.Approved
FramycetinFloctafenine may decrease the excretion rate of Framycetin which could result in a higher serum level.Approved
FurosemideThe therapeutic efficacy of Furosemide can be decreased when used in combination with Floctafenine.Approved, Vet Approved
GabexateFloctafenine may increase the anticoagulant activities of Gabexate.Investigational
GarenoxacinFloctafenine may increase the neuroexcitatory activities of Garenoxacin.Investigational
GatifloxacinFloctafenine may increase the neuroexcitatory activities of Gatifloxacin.Approved, Investigational
GemeprostThe therapeutic efficacy of Gemeprost can be decreased when used in combination with Floctafenine.Approved, Withdrawn
GemifloxacinFloctafenine may increase the neuroexcitatory activities of Gemifloxacin.Approved, Investigational
GeneticinFloctafenine may decrease the excretion rate of Geneticin which could result in a higher serum level.Experimental
GentamicinFloctafenine may decrease the excretion rate of Gentamicin which could result in a higher serum level.Approved, Vet Approved
GENTAMICIN C1AFloctafenine may decrease the excretion rate of GENTAMICIN C1A which could result in a higher serum level.Experimental
GinsengThe risk or severity of adverse effects can be increased when Floctafenine is combined with Ginseng.Approved, Investigational, Nutraceutical
GrepafloxacinFloctafenine may increase the neuroexcitatory activities of Grepafloxacin.Approved, Investigational, Withdrawn
GuacetisalThe risk or severity of adverse effects can be increased when Floctafenine is combined with Guacetisal.Experimental
HalcinonideThe risk or severity of adverse effects can be increased when Floctafenine is combined with Halcinonide.Approved, Investigational, Withdrawn
HaloperidolThe risk or severity of adverse effects can be increased when Floctafenine is combined with Haloperidol.Approved
HE3286The risk or severity of adverse effects can be increased when Floctafenine is combined with HE3286.Investigational
HeparinFloctafenine may increase the anticoagulant activities of Heparin.Approved, Investigational
HigenamineThe risk or severity of adverse effects can be increased when Floctafenine is combined with Higenamine.Investigational
HydralazineFloctafenine may decrease the antihypertensive activities of Hydralazine.Approved
HydrochlorothiazideThe therapeutic efficacy of Hydrochlorothiazide can be decreased when used in combination with Floctafenine.Approved, Vet Approved
HydrocortisoneThe risk or severity of adverse effects can be increased when Floctafenine is combined with Hydrocortisone.Approved, Vet Approved
HydroflumethiazideThe therapeutic efficacy of Hydroflumethiazide can be decreased when used in combination with Floctafenine.Approved, Investigational
Hygromycin BFloctafenine may decrease the excretion rate of Hygromycin B which could result in a higher serum level.Vet Approved
IbandronateThe risk or severity of adverse effects can be increased when Floctafenine is combined with Ibandronate.Approved, Investigational
IbuprofenThe risk or severity of adverse effects can be increased when Floctafenine is combined with Ibuprofen.Approved
IbuproxamThe risk or severity of adverse effects can be increased when Floctafenine is combined with Ibuproxam.Withdrawn
IcatibantThe risk or severity of adverse effects can be increased when Floctafenine is combined with Icatibant.Approved, Investigational
IcosapentThe risk or severity of adverse effects can be increased when Floctafenine is combined with Icosapent.Approved, Nutraceutical
IdraparinuxFloctafenine may increase the anticoagulant activities of Idraparinux.Investigational
IloprostThe therapeutic efficacy of Iloprost can be decreased when used in combination with Floctafenine.Approved, Investigational
ImidaprilThe risk or severity of adverse effects can be increased when Floctafenine is combined with Imidapril.Investigational
Imidazole salicylateThe risk or severity of adverse effects can be increased when Floctafenine is combined with Imidazole salicylate.Experimental
IndapamideThe therapeutic efficacy of Indapamide can be decreased when used in combination with Floctafenine.Approved
IndenololThe risk or severity of adverse effects can be increased when Indenolol is combined with Floctafenine.Withdrawn
IndobufenThe risk or severity of adverse effects can be increased when Floctafenine is combined with Indobufen.Investigational
IndomethacinThe risk or severity of adverse effects can be increased when Floctafenine is combined with Indomethacin.Approved, Investigational
IndoprofenThe risk or severity of adverse effects can be increased when Floctafenine is combined with Indoprofen.Withdrawn
IrbesartanThe risk or severity of adverse effects can be increased when Irbesartan is combined with Floctafenine.Approved, Investigational
IsepamicinFloctafenine may decrease the excretion rate of Isepamicin which could result in a higher serum level.Experimental
IsoxicamThe risk or severity of adverse effects can be increased when Floctafenine is combined with Isoxicam.Withdrawn
IstaroximeThe risk or severity of adverse effects can be increased when Floctafenine is combined with Istaroxime.Investigational
KanamycinFloctafenine may decrease the excretion rate of Kanamycin which could result in a higher serum level.Approved, Investigational, Vet Approved
KebuzoneThe risk or severity of adverse effects can be increased when Floctafenine is combined with Kebuzone.Experimental
KetoprofenThe risk or severity of adverse effects can be increased when Floctafenine is combined with Ketoprofen.Approved, Vet Approved
KetorolacThe risk or severity of adverse effects can be increased when Floctafenine is combined with Ketorolac.Approved
LabetalolThe risk or severity of adverse effects can be increased when Labetalol is combined with Floctafenine.Approved
LandiololThe risk or severity of adverse effects can be increased when Landiolol is combined with Floctafenine.Investigational
LatanoprostThe therapeutic efficacy of Latanoprost can be decreased when used in combination with Floctafenine.Approved, Investigational
Latanoprostene BunodThe therapeutic efficacy of Latanoprostene Bunod can be decreased when used in combination with Floctafenine.Approved, Investigational
LeflunomideThe risk or severity of adverse effects can be increased when Floctafenine is combined with Leflunomide.Approved, Investigational
LepirudinFloctafenine may increase the anticoagulant activities of Lepirudin.Approved
LetaxabanFloctafenine may increase the anticoagulant activities of Letaxaban.Investigational
LevobetaxololThe risk or severity of adverse effects can be increased when Levobetaxolol is combined with Floctafenine.Approved, Investigational
LevobunololThe risk or severity of adverse effects can be increased when Levobunolol is combined with Floctafenine.Approved
LevofloxacinFloctafenine may increase the neuroexcitatory activities of Levofloxacin.Approved, Investigational
LimaprostThe therapeutic efficacy of Limaprost can be decreased when used in combination with Floctafenine.Approved, Investigational
LisinoprilThe risk or severity of adverse effects can be increased when Floctafenine is combined with Lisinopril.Approved, Investigational
LisofyllineThe risk or severity of adverse effects can be increased when Floctafenine is combined with Lisofylline.Investigational
LithiumThe serum concentration of Lithium can be increased when it is combined with Floctafenine.Approved
LomefloxacinFloctafenine may increase the neuroexcitatory activities of Lomefloxacin.Approved, Investigational
LonazolacThe risk or severity of adverse effects can be increased when Floctafenine is combined with Lonazolac.Experimental
LornoxicamThe risk or severity of adverse effects can be increased when Floctafenine is combined with Lornoxicam.Approved, Investigational
LosartanThe risk or severity of adverse effects can be increased when Losartan is combined with Floctafenine.Approved
LoteprednolThe risk or severity of adverse effects can be increased when Floctafenine is combined with Loteprednol.Approved
LoxoprofenThe risk or severity of adverse effects can be increased when Floctafenine is combined with Loxoprofen.Approved, Investigational
LubiprostoneThe therapeutic efficacy of Lubiprostone can be decreased when used in combination with Floctafenine.Approved, Investigational
LumiracoxibThe risk or severity of adverse effects can be increased when Floctafenine is combined with Lumiracoxib.Approved, Investigational
LuprostiolThe therapeutic efficacy of Luprostiol can be decreased when used in combination with Floctafenine.Vet Approved
Magnesium salicylateThe risk or severity of adverse effects can be increased when Floctafenine is combined with Magnesium salicylate.Approved
MasoprocolThe risk or severity of adverse effects can be increased when Floctafenine is combined with Masoprocol.Approved, Investigational
ME-609The risk or severity of adverse effects can be increased when Floctafenine is combined with ME-609.Investigational
Meclofenamic acidThe risk or severity of adverse effects can be increased when Floctafenine is combined with Meclofenamic acid.Approved, Vet Approved
MedrysoneThe risk or severity of adverse effects can be increased when Floctafenine is combined with Medrysone.Approved
Mefenamic acidThe risk or severity of adverse effects can be increased when Floctafenine is combined with Mefenamic acid.Approved
MelagatranFloctafenine may increase the anticoagulant activities of Melagatran.Experimental
MelengestrolThe risk or severity of adverse effects can be increased when Floctafenine is combined with Melengestrol.Vet Approved
MeloxicamThe risk or severity of adverse effects can be increased when Floctafenine is combined with Meloxicam.Approved, Vet Approved
MepindololThe risk or severity of adverse effects can be increased when Mepindolol is combined with Floctafenine.Experimental
MesalazineThe risk or severity of adverse effects can be increased when Floctafenine is combined with Mesalazine.Approved
MetamizoleThe risk or severity of adverse effects can be increased when Floctafenine is combined with Metamizole.Approved, Investigational, Withdrawn
MethotrexateThe serum concentration of Methotrexate can be increased when it is combined with Floctafenine.Approved
MethyclothiazideThe therapeutic efficacy of Methyclothiazide can be decreased when used in combination with Floctafenine.Approved
MethylprednisoloneThe risk or severity of adverse effects can be increased when Floctafenine is combined with Methylprednisolone.Approved, Vet Approved
MetipranololThe risk or severity of adverse effects can be increased when Metipranolol is combined with Floctafenine.Approved
MetolazoneThe therapeutic efficacy of Metolazone can be decreased when used in combination with Floctafenine.Approved
MetoprololThe risk or severity of adverse effects can be increased when Metoprolol is combined with Floctafenine.Approved, Investigational
MicronomicinFloctafenine may decrease the excretion rate of Micronomicin which could result in a higher serum level.Experimental
MifamurtideThe therapeutic efficacy of Mifamurtide can be decreased when used in combination with Floctafenine.Approved, Experimental
MisoprostolThe therapeutic efficacy of Misoprostol can be decreased when used in combination with Floctafenine.Approved
MizoribineThe risk or severity of adverse effects can be increased when Floctafenine is combined with Mizoribine.Investigational
MoexiprilThe risk or severity of adverse effects can be increased when Floctafenine is combined with Moexipril.Approved
MofebutazoneThe risk or severity of adverse effects can be increased when Floctafenine is combined with Mofebutazone.Experimental
MometasoneThe risk or severity of adverse effects can be increased when Floctafenine is combined with Mometasone.Approved, Vet Approved
MorniflumateThe risk or severity of adverse effects can be increased when Morniflumate is combined with Floctafenine.Approved
MoxifloxacinFloctafenine may increase the neuroexcitatory activities of Moxifloxacin.Approved, Investigational
Mycophenolate mofetilThe risk or severity of adverse effects can be increased when Floctafenine is combined with Mycophenolate mofetil.Approved, Investigational
Mycophenolic acidThe risk or severity of adverse effects can be increased when Floctafenine is combined with Mycophenolic acid.Approved
NabumetoneThe risk or severity of adverse effects can be increased when Floctafenine is combined with Nabumetone.Approved
NadololThe risk or severity of adverse effects can be increased when Nadolol is combined with Floctafenine.Approved
NadroparinFloctafenine may increase the anticoagulant activities of Nadroparin.Approved, Investigational
NafamostatThe risk or severity of adverse effects can be increased when Floctafenine is combined with Nafamostat.Approved, Investigational
NaftifineThe risk or severity of adverse effects can be increased when Floctafenine is combined with Naftifine.Approved
Nalidixic AcidFloctafenine may increase the neuroexcitatory activities of Nalidixic Acid.Approved, Investigational
NaproxenThe risk or severity of adverse effects can be increased when Floctafenine is combined with Naproxen.Approved, Vet Approved
NCX 1022The risk or severity of adverse effects can be increased when Floctafenine is combined with NCX 1022.Investigational
NeamineFloctafenine may decrease the excretion rate of Neamine which could result in a higher serum level.Experimental
NebivololThe risk or severity of adverse effects can be increased when Nebivolol is combined with Floctafenine.Approved, Investigational
NemonoxacinFloctafenine may increase the neuroexcitatory activities of Nemonoxacin.Investigational
NeomycinFloctafenine may decrease the excretion rate of Neomycin which could result in a higher serum level.Approved, Vet Approved
NepafenacThe risk or severity of adverse effects can be increased when Floctafenine is combined with Nepafenac.Approved, Investigational
NetilmicinFloctafenine may decrease the excretion rate of Netilmicin which could result in a higher serum level.Approved, Investigational
NifenazoneThe risk or severity of adverse effects can be increased when Floctafenine is combined with Nifenazone.Experimental
Niflumic AcidThe risk or severity of adverse effects can be increased when Floctafenine is combined with Niflumic Acid.Approved
NimesulideThe risk or severity of adverse effects can be increased when Floctafenine is combined with Nimesulide.Approved, Investigational, Withdrawn
NitroaspirinThe risk or severity of adverse effects can be increased when Floctafenine is combined with Nitroaspirin.Investigational
NorfloxacinFloctafenine may increase the neuroexcitatory activities of Norfloxacin.Approved
OfloxacinFloctafenine may increase the neuroexcitatory activities of Ofloxacin.Approved
Oleoyl-estroneThe risk or severity of adverse effects can be increased when Floctafenine is combined with Oleoyl-estrone.Investigational
OlmesartanThe risk or severity of adverse effects can be increased when Olmesartan is combined with Floctafenine.Approved, Investigational
OlopatadineThe risk or severity of adverse effects can be increased when Floctafenine is combined with Olopatadine.Approved
OlsalazineThe risk or severity of adverse effects can be increased when Floctafenine is combined with Olsalazine.Approved
Omacetaxine mepesuccinateThe risk or severity of bleeding can be increased when Floctafenine is combined with Omacetaxine mepesuccinate.Approved, Investigational
OmapatrilatThe risk or severity of adverse effects can be increased when Floctafenine is combined with Omapatrilat.Investigational
OrgoteinThe risk or severity of adverse effects can be increased when Floctafenine is combined with Orgotein.Vet Approved
OtamixabanFloctafenine may increase the anticoagulant activities of Otamixaban.Investigational
OxaprozinThe risk or severity of adverse effects can be increased when Floctafenine is combined with Oxaprozin.Approved
Oxolinic acidFloctafenine may increase the neuroexcitatory activities of Oxolinic acid.Experimental
OxprenololThe risk or severity of adverse effects can be increased when Oxprenolol is combined with Floctafenine.Approved
OxyphenbutazoneThe risk or severity of adverse effects can be increased when Floctafenine is combined with Oxyphenbutazone.Approved, Withdrawn
PalmidrolThe risk or severity of adverse effects can be increased when Floctafenine is combined with Palmidrol.Experimental, Nutraceutical
PamidronateThe risk or severity of adverse effects can be increased when Floctafenine is combined with Pamidronate.Approved
ParamethasoneThe risk or severity of adverse effects can be increased when Floctafenine is combined with Paramethasone.Approved
ParecoxibThe risk or severity of adverse effects can be increased when Floctafenine is combined with Parecoxib.Approved
ParomomycinFloctafenine may decrease the excretion rate of Paromomycin which could result in a higher serum level.Approved, Investigational
ParthenolideThe risk or severity of adverse effects can be increased when Floctafenine is combined with Parthenolide.Approved, Investigational
PazufloxacinFloctafenine may increase the neuroexcitatory activities of Pazufloxacin.Investigational
PefloxacinFloctafenine may increase the neuroexcitatory activities of Pefloxacin.Approved
PenbutololThe risk or severity of adverse effects can be increased when Penbutolol is combined with Floctafenine.Approved, Investigational
Pentaerythritol TetranitrateFloctafenine may increase the anticoagulant activities of Pentaerythritol Tetranitrate.Approved
Pentosan PolysulfateFloctafenine may increase the anticoagulant activities of Pentosan Polysulfate.Approved
PerindoprilThe risk or severity of adverse effects can be increased when Floctafenine is combined with Perindopril.Approved
PhenindioneFloctafenine may increase the anticoagulant activities of Phenindione.Approved, Investigational
PhenprocoumonFloctafenine may increase the anticoagulant activities of Phenprocoumon.Approved, Investigational
PhenylbutazoneThe risk or severity of adverse effects can be increased when Floctafenine is combined with Phenylbutazone.Approved, Vet Approved
PimecrolimusThe risk or severity of adverse effects can be increased when Floctafenine is combined with Pimecrolimus.Approved, Investigational
PindololThe risk or severity of adverse effects can be increased when Pindolol is combined with Floctafenine.Approved, Investigational
Pipemidic acidFloctafenine may increase the neuroexcitatory activities of Pipemidic acid.Experimental
PiretanideThe therapeutic efficacy of Piretanide can be decreased when used in combination with Floctafenine.Approved
PirfenidoneThe risk or severity of adverse effects can be increased when Floctafenine is combined with Pirfenidone.Approved, Investigational
Piromidic acidFloctafenine may increase the neuroexcitatory activities of Piromidic acid.Experimental
PiroxicamThe risk or severity of adverse effects can be increased when Floctafenine is combined with Piroxicam.Approved, Investigational
PirprofenThe risk or severity of adverse effects can be increased when Floctafenine is combined with Pirprofen.Experimental
PitolisantThe risk or severity of adverse effects can be increased when Floctafenine is combined with Pitolisant.Approved, Investigational
Platelet Activating FactorThe risk or severity of adverse effects can be increased when Platelet Activating Factor is combined with Floctafenine.Experimental
PlazomicinFloctafenine may decrease the excretion rate of Plazomicin which could result in a higher serum level.Investigational
PolythiazideThe therapeutic efficacy of Polythiazide can be decreased when used in combination with Floctafenine.Approved
PomalidomideThe risk or severity of adverse effects can be increased when Floctafenine is combined with Pomalidomide.Approved
Potassium CitrateFloctafenine may increase the anticoagulant activities of Potassium Citrate.Approved, Investigational, Vet Approved
PractololThe risk or severity of adverse effects can be increased when Practolol is combined with Floctafenine.Approved
PralatrexateThe serum concentration of Pralatrexate can be increased when it is combined with Floctafenine.Approved, Investigational
PranoprofenThe risk or severity of adverse effects can be increased when Floctafenine is combined with Pranoprofen.Experimental, Investigational
PrasteroneThe risk or severity of adverse effects can be increased when Floctafenine is combined with Prasterone.Approved, Investigational, Nutraceutical
Prasterone sulfateThe risk or severity of adverse effects can be increased when Floctafenine is combined with Prasterone sulfate.Investigational
PrednicarbateThe risk or severity of adverse effects can be increased when Floctafenine is combined with Prednicarbate.Approved, Investigational
PrednisoloneThe risk or severity of adverse effects can be increased when Floctafenine is combined with Prednisolone.Approved, Vet Approved
PrednisoneThe risk or severity of adverse effects can be increased when Floctafenine is combined with Prednisone.Approved, Vet Approved
PregnenoloneThe risk or severity of adverse effects can be increased when Floctafenine is combined with Pregnenolone.Approved, Experimental, Investigational
ProbenecidThe serum concentration of Floctafenine can be increased when it is combined with Probenecid.Approved, Investigational
ProglumetacinThe risk or severity of adverse effects can be increased when Floctafenine is combined with Proglumetacin.Experimental
PropacetamolThe risk or severity of adverse effects can be increased when Floctafenine is combined with Propacetamol.Approved, Investigational
PropafenoneThe risk or severity of adverse effects can be increased when Propafenone is combined with Floctafenine.Approved
PropranololThe risk or severity of adverse effects can be increased when Propranolol is combined with Floctafenine.Approved, Investigational
PropyphenazoneThe risk or severity of adverse effects can be increased when Floctafenine is combined with Propyphenazone.Experimental
ProquazoneThe risk or severity of adverse effects can be increased when Floctafenine is combined with Proquazone.Experimental
Prostaglandin B2The therapeutic efficacy of Prostaglandin B2 can be decreased when used in combination with Floctafenine.Experimental
Prostaglandin G2The therapeutic efficacy of Prostaglandin G2 can be decreased when used in combination with Floctafenine.Experimental
ProstaleneThe therapeutic efficacy of Prostalene can be decreased when used in combination with Floctafenine.Vet Approved
Protein CFloctafenine may increase the anticoagulant activities of Protein C.Approved
Protein S humanFloctafenine may increase the anticoagulant activities of Protein S human.Approved
ProtocatechualdehydeFloctafenine may increase the anticoagulant activities of Protocatechualdehyde.Approved
PrulifloxacinFloctafenine may increase the neuroexcitatory activities of Prulifloxacin.Investigational
PTC299The risk or severity of adverse effects can be increased when Floctafenine is combined with PTC299.Investigational
PuromycinFloctafenine may decrease the excretion rate of Puromycin which could result in a higher serum level.Experimental
QuinaprilThe risk or severity of adverse effects can be increased when Floctafenine is combined with Quinapril.Approved, Investigational
QuinethazoneThe therapeutic efficacy of Quinethazone can be decreased when used in combination with Floctafenine.Approved
RamiprilThe risk or severity of adverse effects can be increased when Floctafenine is combined with Ramipril.Approved
RescinnamineThe risk or severity of adverse effects can be increased when Floctafenine is combined with Rescinnamine.Approved
ResveratrolThe risk or severity of adverse effects can be increased when Floctafenine is combined with Resveratrol.Approved, Experimental, Investigational
ReviparinFloctafenine may increase the anticoagulant activities of Reviparin.Approved, Investigational
RibostamycinFloctafenine may decrease the excretion rate of Ribostamycin which could result in a higher serum level.Approved, Investigational
RimexoloneThe risk or severity of adverse effects can be increased when Floctafenine is combined with Rimexolone.Approved
RisedronateThe risk or severity of adverse effects can be increased when Floctafenine is combined with Risedronate.Approved, Investigational
RivaroxabanFloctafenine may increase the anticoagulant activities of Rivaroxaban.Approved
RofecoxibThe risk or severity of adverse effects can be increased when Floctafenine is combined with Rofecoxib.Approved, Investigational, Withdrawn
RosoxacinFloctafenine may increase the neuroexcitatory activities of Rosoxacin.Approved, Investigational
RufloxacinFloctafenine may increase the neuroexcitatory activities of Rufloxacin.Experimental
SacubitrilThe risk or severity of adverse effects can be increased when Sacubitril is combined with Floctafenine.Approved
SalicylamideThe risk or severity of adverse effects can be increased when Floctafenine is combined with Salicylamide.Approved
Salicylic acidThe risk or severity of adverse effects can be increased when Floctafenine is combined with Salicylic acid.Approved, Investigational, Vet Approved
SalsalateThe risk or severity of adverse effects can be increased when Floctafenine is combined with Salsalate.Approved
SaprisartanThe risk or severity of adverse effects can be increased when Saprisartan is combined with Floctafenine.Experimental
SaralasinThe risk or severity of adverse effects can be increased when Saralasin is combined with Floctafenine.Investigational
SarilumabSarilumab may increase the immunosuppressive activities of Floctafenine.Approved, Investigational
SeliciclibThe risk or severity of adverse effects can be increased when Floctafenine is combined with Seliciclib.Investigational
SemapimodThe risk or severity of adverse effects can be increased when Floctafenine is combined with Semapimod.Investigational
SeratrodastThe risk or severity of adverse effects can be increased when Floctafenine is combined with Seratrodast.Approved
SerrapeptaseThe risk or severity of adverse effects can be increased when Floctafenine is combined with Serrapeptase.Investigational
SisomicinFloctafenine may decrease the excretion rate of Sisomicin which could result in a higher serum level.Investigational
SitafloxacinFloctafenine may increase the neuroexcitatory activities of Sitafloxacin.Experimental, Investigational
Sodium CitrateFloctafenine may increase the anticoagulant activities of Sodium Citrate.Approved, Investigational
Sodium phosphateSodium phosphate may increase the nephrotoxic activities of Floctafenine.Approved
SotalolThe risk or severity of adverse effects can be increased when Sotalol is combined with Floctafenine.Approved
SparfloxacinFloctafenine may increase the neuroexcitatory activities of Sparfloxacin.Approved, Investigational
SpiraprilThe risk or severity of adverse effects can be increased when Floctafenine is combined with Spirapril.Approved
SpironolactoneFloctafenine may decrease the antihypertensive activities of Spironolactone.Approved
SRT501The risk or severity of adverse effects can be increased when Floctafenine is combined with SRT501.Investigational
StreptomycinFloctafenine may decrease the excretion rate of Streptomycin which could result in a higher serum level.Approved, Vet Approved
SulfasalazineThe risk or severity of adverse effects can be increased when Floctafenine is combined with Sulfasalazine.Approved
SulindacThe risk or severity of adverse effects can be increased when Floctafenine is combined with Sulindac.Approved, Investigational
SulodexideFloctafenine may increase the anticoagulant activities of Sulodexide.Approved, Investigational
SulprostoneThe therapeutic efficacy of Sulprostone can be decreased when used in combination with Floctafenine.Investigational
SuprofenThe risk or severity of adverse effects can be increased when Floctafenine is combined with Suprofen.Approved, Withdrawn
SuxibuzoneThe risk or severity of adverse effects can be increased when Floctafenine is combined with Suxibuzone.Experimental
TacrolimusFloctafenine may increase the nephrotoxic activities of Tacrolimus.Approved, Investigational
TafluprostThe therapeutic efficacy of Tafluprost can be decreased when used in combination with Floctafenine.Approved
TalinololThe risk or severity of adverse effects can be increased when Talinolol is combined with Floctafenine.Investigational
TalniflumateThe risk or severity of adverse effects can be increased when Talniflumate is combined with Floctafenine.Approved
TarenflurbilThe risk or severity of adverse effects can be increased when Floctafenine is combined with Tarenflurbil.Investigational
TasosartanThe risk or severity of adverse effects can be increased when Tasosartan is combined with Floctafenine.Approved
Technetium Tc-99m etidronateThe risk or severity of adverse effects can be increased when Floctafenine is combined with Technetium Tc-99m etidronate.Approved
Technetium Tc-99m medronateThe risk or severity of adverse effects can be increased when Floctafenine is combined with Technetium Tc-99m medronate.Approved
TelmisartanThe risk or severity of adverse effects can be increased when Telmisartan is combined with Floctafenine.Approved, Investigational
TemafloxacinFloctafenine may increase the neuroexcitatory activities of Temafloxacin.Withdrawn
TemocaprilThe risk or severity of adverse effects can be increased when Floctafenine is combined with Temocapril.Experimental, Investigational
TenidapThe risk or severity of adverse effects can be increased when Floctafenine is combined with Tenidap.Experimental
Tenofovir disoproxilThe risk or severity of adverse effects can be increased when Floctafenine is combined with Tenofovir disoproxil.Approved, Investigational
TenoxicamThe risk or severity of adverse effects can be increased when Floctafenine is combined with Tenoxicam.Approved
TepoxalinThe risk or severity of adverse effects can be increased when Floctafenine is combined with Tepoxalin.Vet Approved
TerbutalineThe risk or severity of adverse effects can be increased when Terbutaline is combined with Floctafenine.Approved
TeriflunomideThe risk or severity of adverse effects can be increased when Floctafenine is combined with Teriflunomide.Approved
TertatololThe risk or severity of adverse effects can be increased when Tertatolol is combined with Floctafenine.Experimental
Tiaprofenic acidThe risk or severity of adverse effects can be increased when Floctafenine is combined with Tiaprofenic acid.Approved
Tiludronic acidThe risk or severity of adverse effects can be increased when Floctafenine is combined with Tiludronic acid.Approved, Investigational, Vet Approved
TimololThe risk or severity of adverse effects can be increased when Timolol is combined with Floctafenine.Approved
TinoridineThe risk or severity of adverse effects can be increased when Floctafenine is combined with Tinoridine.Investigational
TixocortolThe risk or severity of adverse effects can be increased when Floctafenine is combined with Tixocortol.Approved, Withdrawn
TobramycinFloctafenine may decrease the excretion rate of Tobramycin which could result in a higher serum level.Approved, Investigational
Tolfenamic AcidThe risk or severity of adverse effects can be increased when Floctafenine is combined with Tolfenamic Acid.Approved, Investigational
TolmetinThe risk or severity of adverse effects can be increased when Floctafenine is combined with Tolmetin.Approved
TorasemideThe therapeutic efficacy of Torasemide can be decreased when used in combination with Floctafenine.Approved
TrandolaprilThe risk or severity of adverse effects can be increased when Floctafenine is combined with Trandolapril.Approved
TranilastThe risk or severity of adverse effects can be increased when Floctafenine is combined with Tranilast.Approved, Investigational
TravoprostThe therapeutic efficacy of Travoprost can be decreased when used in combination with Floctafenine.Approved
TreprostinilThe risk or severity of adverse effects can be increased when Treprostinil is combined with Floctafenine.Approved, Investigational
TriamcinoloneThe risk or severity of adverse effects can be increased when Floctafenine is combined with Triamcinolone.Approved, Vet Approved
TriamtereneFloctafenine may decrease the antihypertensive activities of Triamterene.Approved
TribenosideThe risk or severity of adverse effects can be increased when Floctafenine is combined with Tribenoside.Experimental
TrichlormethiazideThe therapeutic efficacy of Trichlormethiazide can be decreased when used in combination with Floctafenine.Approved, Vet Approved
TriptolideThe risk or severity of adverse effects can be increased when Floctafenine is combined with Triptolide.Investigational
Trolamine salicylateThe risk or severity of adverse effects can be increased when Floctafenine is combined with Trolamine salicylate.Approved
TrovafloxacinFloctafenine may increase the neuroexcitatory activities of Trovafloxacin.Approved, Investigational, Withdrawn
TroxerutinFloctafenine may increase the anticoagulant activities of Troxerutin.Investigational
UlobetasolThe risk or severity of adverse effects can be increased when Floctafenine is combined with Ulobetasol.Approved
UnoprostoneThe therapeutic efficacy of Unoprostone can be decreased when used in combination with Floctafenine.Approved, Investigational
ValdecoxibThe risk or severity of adverse effects can be increased when Floctafenine is combined with Valdecoxib.Approved, Investigational, Withdrawn
ValsartanThe risk or severity of adverse effects can be increased when Valsartan is combined with Floctafenine.Approved, Investigational
VancomycinThe serum concentration of Vancomycin can be increased when it is combined with Floctafenine.Approved
WarfarinFloctafenine may increase the anticoagulant activities of Warfarin.Approved
XimelagatranFloctafenine may increase the anticoagulant activities of Ximelagatran.Approved, Investigational, Withdrawn
ZaltoprofenThe risk or severity of adverse effects can be increased when Floctafenine is combined with Zaltoprofen.Approved, Investigational
ZileutonThe risk or severity of adverse effects can be increased when Floctafenine is combined with Zileuton.Approved, Investigational, Withdrawn
ZofenoprilThe risk or severity of adverse effects can be increased when Floctafenine is combined with Zofenopril.Experimental
Zoledronic acidThe risk or severity of adverse effects can be increased when Floctafenine is combined with Zoledronic acid.Approved
ZomepiracThe risk or severity of adverse effects can be increased when Floctafenine is combined with Zomepirac.Withdrawn
Food Interactions
Not Available

References

Synthesis Reference

U.S. Patent 3,644,368.

General References
Not Available
External Links
PubChem Compound
76958517
PubChem Substance
310264938
Wikipedia
Floctafenine
ATC Codes
N02BG04 — Floctafenine
AHFS Codes
  • 28:08.92 — Miscellaneous Analgesics and Antipyretics

Clinical Trials

Clinical Trials
Not Available

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage forms
FormRouteStrength
TabletOral200 mg
TabletOral400 mg
Prices
Not Available
Patents
Not Available

Properties

State
Solid
Experimental Properties
PropertyValueSource
melting point (°C)179-180U.S. Patent 3,644,368.
Predicted Properties
PropertyValueSource
Water Solubility0.0346 mg/mLALOGPS
logP3.05ALOGPS
logP4.43ChemAxon
logS-4.1ALOGPS
pKa (Strongest Acidic)13.62ChemAxon
pKa (Strongest Basic)5.84ChemAxon
Physiological Charge0ChemAxon
Hydrogen Acceptor Count5ChemAxon
Hydrogen Donor Count3ChemAxon
Polar Surface Area91.68 Å2ChemAxon
Rotatable Bond Count8ChemAxon
Refractivity98.72 m3·mol-1ChemAxon
Polarizability38.11 Å3ChemAxon
Number of Rings3ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleNoChemAxon
MDDR-like RuleYesChemAxon
Predicted ADMET features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
SpectrumSpectrum TypeSplash Key
Predicted MS/MS Spectrum - 10V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 20V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 40V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 10V, Negative (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 20V, Negative (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 40V, Negative (Annotated)Predicted LC-MS/MSNot Available

Taxonomy

Description
This compound belongs to the class of organic compounds known as 4-aminoquinolines. These are organic compounds containing an amino group attached to the 4-position of a quinoline ring system.
Kingdom
Organic compounds
Super Class
Organoheterocyclic compounds
Class
Quinolines and derivatives
Sub Class
Aminoquinolines and derivatives
Direct Parent
4-aminoquinolines
Alternative Parents
Aminobenzoic acids and derivatives / Benzoic acid esters / Aniline and substituted anilines / Benzoyl derivatives / Aminopyridines and derivatives / Glycerolipids / Primary aromatic amines / Heteroaromatic compounds / Vinylogous amides / Carboxylic acid esters
show 10 more
Substituents
4-aminoquinoline / Benzoate ester / Aminobenzoic acid or derivatives / Benzoic acid or derivatives / Benzoyl / Aniline or substituted anilines / Aminopyridine / Glycerolipid / Monocyclic benzene moiety / Primary aromatic amine
show 25 more
Molecular Framework
Aromatic heteropolycyclic compounds
External Descriptors
Not Available

Drug created on June 09, 2014 14:37 / Updated on June 17, 2018 20:13