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Identification
NameProparacaine
Accession NumberDB00807  (APRD00522)
TypeSmall Molecule
GroupsApproved, Vet Approved
DescriptionProparacaine is a topical anesthetic drug of the amino ester group. It is available as its hydrochloride salt in ophthalmic solutions at a concentration of 0.5%.
Structure
Thumb
Synonyms
Proximetacaina
Proxymetacaine
Proxymetacainum
External Identifiers Not Available
Approved Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
AlcaineSolution / drops0.5 %OphthalmicAlcon Canada Inc1971-12-31Not applicableCanada
Diocaine Solution 0.5%Liquid0.5 %Ophthalmic; TopicalDioptic Pharmaceuticals Inc1994-12-31Not applicableCanada
Odan-proparacaineSolution.5 %Ophthalmic; TopicalOdan Laboratories Ltd1985-12-31Not applicableCanada
OphtheticSolution / drops.5 %OphthalmicAllergan Inc1964-12-312011-08-04Canada
PMS-proparacaine Hydrochloride Oph Soltn 0.5%Solution / drops.5 %OphthalmicPharmascience Inc1992-12-311996-09-10Canada
R.O.-parcaine Dps 5mg/mlSolution / drops5 mgOphthalmicRichmond Pharmaceuticals Inc.1993-12-311997-08-11Canada
Approved Generic Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
AlcaineSolution / drops5 mg/mLOphthalmicAlcon Laboratories, Inc.1973-10-19Not applicableUs
Proparacaine HydrochlorideSolution / drops5 mg/mLOphthalmicA S Medication Solutions Llc2000-03-16Not applicableUs
Proparacaine HydrochlorideSolution / drops5 mg/mLOphthalmicHenry Schein Inc.2015-05-13Not applicableUs
Proparacaine HydrochlorideSolution / drops5 mg/mLOphthalmicA S Medication Solutions2000-03-16Not applicableUs
Proparacaine HydrochlorideSolution / drops5 mg/mLOphthalmicAkorn, Inc.2000-03-16Not applicableUs
Proparacaine HydrochlorideSolution / drops5 mg/mLOphthalmicSandoz Inc.2000-06-05Not applicableUs
Proparacaine HydrochlorideSolution / drops5 mg/mLOphthalmicREMEDYREPACK INC.2016-07-29Not applicableUs
Proparacaine HydrochlorideSolution5 mg/mLOphthalmicRebel Distributors Corp1995-09-29Not applicableUs
Proparacaine HydrochlorideSolution / drops5 mg/mLOphthalmicBausch & Lomb Incorporated1995-09-29Not applicableUs
Proparacaine HydrochlorideSolution / drops5 mg/mLOphthalmicMwi2015-03-27Not applicableUs
Proparacaine HydrochlorideSolution / drops5 mg/mLOphthalmicA S Medication Solutions1995-09-29Not applicableUs
Proparacaine HydrochlorideSolution / drops5 mg/mLOphthalmicH.J. Harkins Company, Inc.1995-09-29Not applicableUs
Proparacaine HydrochlorideSolution / drops5 mg/mLOphthalmicPreferred Pharmaceuticals, Inc.2014-04-28Not applicableUs
Proparacaine HydrochlorideSolution5 mg/mLOphthalmicSTAT Rx USA LLC2000-06-05Not applicableUs
Proparacaine HydrochlorideSolution / drops5 mg/mLOphthalmicA S Medication Solutions2000-06-05Not applicableUs
Approved Over the Counter ProductsNot Available
Unapproved/Other Products Not Available
International Brands
NameCompany
Ak-TaineNot Available
DiocaineNot Available
Ocu-CaineNot Available
OphthaineNot Available
OphtheticNot Available
Spectro-CaineNot Available
Brand mixtures
NameLabellerIngredients
FlucaineO Cu Soft, Inc.
Fluorescein Sodium and Proparacaine HydrochlorideAltaire Pharmaceuticals Inc.
Odan-fluoracaineOdan Laboratories Ltd
Salts
Name/CASStructureProperties
Proparacaine hydrochloride
5875-06-9
Thumb
  • InChI Key: BFUUJUGQJUTPAF-UHFFFAOYSA-N
  • Monoisotopic Mass: 330.171020447
  • Average Mass: 330.85
DBSALT000459
Categories
UNIIB4OB0JHI1X
CAS number499-67-2
WeightAverage: 294.3892
Monoisotopic: 294.194342708
Chemical FormulaC16H26N2O3
InChI KeyKCLANYCVBBTKTO-UHFFFAOYSA-N
InChI
InChI=1S/C16H26N2O3/c1-4-10-20-15-8-7-13(12-14(15)17)16(19)21-11-9-18(5-2)6-3/h7-8,12H,4-6,9-11,17H2,1-3H3
IUPAC Name
2-(diethylamino)ethyl 3-amino-4-propoxybenzoate
SMILES
CCCOC1=C(N)C=C(C=C1)C(=O)OCCN(CC)CC
Pharmacology
IndicationUsed as a local (ophthalmic) anesthetic.
Structured Indications Not Available
PharmacodynamicsProparacaine stabilizes the neuronal membrane by inhibiting the ionic fluxes required for the initiation and conduction of impulses thereby effecting local anesthetic action. More specifically, proparacaine appears to bind or antagonize the function of voltage gated sodium channels.
Mechanism of actionThe exact mechanism whereby proparacaine and other local anesthetics influence the permeability of the cell membrane is unknown; however, several studies indicate that local anesthetics may limit sodium ion permeability through the lipid layer of the nerve cell membrane. Proparacaine may alter epithelial sodium channels through interaction with channel protein residues. This limitation prevents the fundamental change necessary for the generation of the action potential.
TargetKindPharmacological actionActionsOrganismUniProt ID
Sodium channel protein type 10 subunit alphaProteinyes
inhibitor
HumanQ9Y5Y9 details
Related Articles
AbsorptionNot Available
Volume of distributionNot Available
Protein bindingNot Available
Metabolism

Plasma

Route of eliminationNot Available
Half lifeNot Available
ClearanceNot Available
ToxicityNot Available
Affected organisms
  • Humans and other mammals
Pathways
PathwayCategorySMPDB ID
Proparacaine Action PathwayDrug actionSMP00403
SNP Mediated EffectsNot Available
SNP Mediated Adverse Drug ReactionsNot Available
Interactions
Drug Interactions
DrugInteractionDrug group
1,1,1,2 TetrafluoroethaneThe risk or severity of adverse effects can be increased when Proparacaine is combined with 1,1,1,2 Tetrafluoroethane.Investigational
7-NitroindazoleThe risk or severity of adverse effects can be increased when Proparacaine is combined with 7-Nitroindazole.Experimental
AcepromazineThe risk or severity of adverse effects can be increased when Proparacaine is combined with Acepromazine.Approved, Vet Approved
AceprometazineThe risk or severity of adverse effects can be increased when Proparacaine is combined with Aceprometazine.Approved
adipiplonThe risk or severity of adverse effects can be increased when Proparacaine is combined with adipiplon.Investigational
AgomelatineThe risk or severity of adverse effects can be increased when Proparacaine is combined with Agomelatine.Approved, Investigational
AlfaxaloneThe risk or severity of adverse effects can be increased when Proparacaine is combined with Alfaxalone.Vet Approved
AlfentanilThe risk or severity of adverse effects can be increased when Alfentanil is combined with Proparacaine.Approved, Illicit
AlphacetylmethadolThe risk or severity of adverse effects can be increased when Proparacaine is combined with Alphacetylmethadol.Experimental, Illicit
AlprazolamThe risk or severity of adverse effects can be increased when Alprazolam is combined with Proparacaine.Approved, Illicit, Investigational
AmisulprideThe risk or severity of adverse effects can be increased when Proparacaine is combined with Amisulpride.Approved, Investigational
AmitriptylineThe risk or severity of adverse effects can be increased when Proparacaine is combined with Amitriptyline.Approved
AmobarbitalThe risk or severity of adverse effects can be increased when Proparacaine is combined with Amobarbital.Approved, Illicit
AmoxapineThe risk or severity of adverse effects can be increased when Proparacaine is combined with Amoxapine.Approved
AmperozideThe risk or severity of adverse effects can be increased when Proparacaine is combined with Amperozide.Experimental
AripiprazoleThe risk or severity of adverse effects can be increased when Proparacaine is combined with Aripiprazole.Approved, Investigational
ArticaineThe risk or severity of adverse effects can be increased when Proparacaine is combined with Articaine.Approved
AsenapineThe risk or severity of adverse effects can be increased when Proparacaine is combined with Asenapine.Approved
AzaperoneThe risk or severity of adverse effects can be increased when Proparacaine is combined with Azaperone.Vet Approved
AzelastineProparacaine may increase the central nervous system depressant (CNS depressant) activities of Azelastine.Approved
AzelastineThe risk or severity of adverse effects can be increased when Proparacaine is combined with Azelastine.Approved
BaclofenThe risk or severity of adverse effects can be increased when Proparacaine is combined with Baclofen.Approved
BarbitalThe risk or severity of adverse effects can be increased when Proparacaine is combined with Barbital.Illicit
BenperidolThe risk or severity of adverse effects can be increased when Proparacaine is combined with Benperidol.Investigational
BenzocaineThe risk or severity of adverse effects can be increased when Proparacaine is combined with Benzocaine.Approved
Benzyl alcoholThe risk or severity of adverse effects can be increased when Proparacaine is combined with Benzyl alcohol.Approved
BrexpiprazoleThe risk or severity of adverse effects can be increased when Proparacaine is combined with Brexpiprazole.Approved
BrimonidineThe risk or severity of adverse effects can be increased when Proparacaine is combined with Brimonidine.Approved
BrimonidineBrimonidine may increase the central nervous system depressant (CNS depressant) activities of Proparacaine.Approved
BromazepamThe risk or severity of adverse effects can be increased when Proparacaine is combined with Bromazepam.Approved, Illicit
BrompheniramineThe risk or severity of adverse effects can be increased when Proparacaine is combined with Brompheniramine.Approved
BrotizolamThe risk or severity of adverse effects can be increased when Proparacaine is combined with Brotizolam.Approved, Withdrawn
BupivacaineThe risk or severity of adverse effects can be increased when Bupivacaine is combined with Proparacaine.Approved, Investigational
BuprenorphineProparacaine may increase the central nervous system depressant (CNS depressant) activities of Buprenorphine.Approved, Illicit, Investigational, Vet Approved
BuspironeThe risk or severity of adverse effects can be increased when Buspirone is combined with Proparacaine.Approved, Investigational
ButabarbitalThe risk or severity of adverse effects can be increased when Butabarbital is combined with Proparacaine.Approved, Illicit
ButacaineThe risk or severity of adverse effects can be increased when Proparacaine is combined with Butacaine.Vet Approved
ButalbitalThe risk or severity of adverse effects can be increased when Proparacaine is combined with Butalbital.Approved, Illicit
ButambenThe risk or severity of adverse effects can be increased when Proparacaine is combined with Butamben.Approved
ButethalThe risk or severity of adverse effects can be increased when Proparacaine is combined with Butethal.Approved, Illicit
ButorphanolThe risk or severity of adverse effects can be increased when Butorphanol is combined with Proparacaine.Approved, Illicit, Vet Approved
CarbamazepineThe risk or severity of adverse effects can be increased when Carbamazepine is combined with Proparacaine.Approved, Investigational
CarbinoxamineThe risk or severity of adverse effects can be increased when Proparacaine is combined with Carbinoxamine.Approved
CarfentanilThe risk or severity of adverse effects can be increased when Proparacaine is combined with Carfentanil.Illicit, Vet Approved
CarisoprodolThe risk or severity of adverse effects can be increased when Proparacaine is combined with Carisoprodol.Approved
CetirizineThe risk or severity of adverse effects can be increased when Proparacaine is combined with Cetirizine.Approved
Chloral hydrateThe risk or severity of adverse effects can be increased when Proparacaine is combined with Chloral hydrate.Approved, Illicit, Vet Approved
ChlordiazepoxideThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Proparacaine.Approved, Illicit
ChlormezanoneThe risk or severity of adverse effects can be increased when Proparacaine is combined with Chlormezanone.Approved, Withdrawn
ChloroprocaineThe risk or severity of adverse effects can be increased when Proparacaine is combined with Chloroprocaine.Approved
ChlorphenamineThe risk or severity of adverse effects can be increased when Proparacaine is combined with Chlorphenamine.Approved
ChlorpromazineThe risk or severity of adverse effects can be increased when Chlorpromazine is combined with Proparacaine.Approved, Vet Approved
ChlorprothixeneThe risk or severity of adverse effects can be increased when Proparacaine is combined with Chlorprothixene.Approved, Withdrawn
ChlorzoxazoneThe risk or severity of adverse effects can be increased when Proparacaine is combined with Chlorzoxazone.Approved
CinchocaineThe risk or severity of adverse effects can be increased when Cinchocaine is combined with Proparacaine.Approved, Vet Approved
CitalopramThe risk or severity of adverse effects can be increased when Proparacaine is combined with Citalopram.Approved
ClemastineThe risk or severity of adverse effects can be increased when Proparacaine is combined with Clemastine.Approved
ClidiniumThe risk or severity of adverse effects can be increased when Proparacaine is combined with Clidinium.Approved
ClobazamThe risk or severity of adverse effects can be increased when Proparacaine is combined with Clobazam.Approved, Illicit
clomethiazoleThe risk or severity of adverse effects can be increased when Proparacaine is combined with clomethiazole.Investigational
ClomipramineThe risk or severity of adverse effects can be increased when Proparacaine is combined with Clomipramine.Approved, Vet Approved
ClonazepamThe risk or severity of adverse effects can be increased when Proparacaine is combined with Clonazepam.Approved, Illicit
ClonidineThe risk or severity of adverse effects can be increased when Proparacaine is combined with Clonidine.Approved
ClorazepateThe risk or severity of adverse effects can be increased when Clorazepate is combined with Proparacaine.Approved, Illicit
ClozapineThe risk or severity of adverse effects can be increased when Clozapine is combined with Proparacaine.Approved
CocaineThe risk or severity of adverse effects can be increased when Proparacaine is combined with Cocaine.Approved, Illicit
CodeineThe risk or severity of adverse effects can be increased when Codeine is combined with Proparacaine.Approved, Illicit
CyclizineThe risk or severity of adverse effects can be increased when Proparacaine is combined with Cyclizine.Approved
CyclobenzaprineThe risk or severity of adverse effects can be increased when Proparacaine is combined with Cyclobenzaprine.Approved
CyproheptadineThe risk or severity of adverse effects can be increased when Proparacaine is combined with Cyproheptadine.Approved
DantroleneThe risk or severity of adverse effects can be increased when Proparacaine is combined with Dantrolene.Approved
DapiprazoleThe risk or severity of adverse effects can be increased when Dapiprazole is combined with Proparacaine.Approved
DapoxetineThe risk or severity of adverse effects can be increased when Proparacaine is combined with Dapoxetine.Investigational
deramciclaneThe risk or severity of adverse effects can be increased when Proparacaine is combined with deramciclane.Investigational
DesfluraneThe risk or severity of adverse effects can be increased when Proparacaine is combined with Desflurane.Approved
DesipramineThe risk or severity of adverse effects can be increased when Proparacaine is combined with Desipramine.Approved
DesloratadineThe risk or severity of adverse effects can be increased when Proparacaine is combined with Desloratadine.Approved, Investigational
DesvenlafaxineThe risk or severity of adverse effects can be increased when Proparacaine is combined with Desvenlafaxine.Approved
DetomidineThe risk or severity of adverse effects can be increased when Proparacaine is combined with Detomidine.Vet Approved
DexbrompheniramineThe risk or severity of adverse effects can be increased when Proparacaine is combined with Dexbrompheniramine.Approved
DexmedetomidineThe risk or severity of adverse effects can be increased when Dexmedetomidine is combined with Proparacaine.Approved, Vet Approved
DextromoramideThe risk or severity of adverse effects can be increased when Proparacaine is combined with Dextromoramide.Experimental, Illicit
DextropropoxypheneThe risk or severity of adverse effects can be increased when Dextropropoxyphene is combined with Proparacaine.Approved, Illicit, Withdrawn
DezocineThe risk or severity of adverse effects can be increased when Proparacaine is combined with Dezocine.Approved
DiazepamThe risk or severity of adverse effects can be increased when Proparacaine is combined with Diazepam.Approved, Illicit, Vet Approved
DifenoxinThe risk or severity of adverse effects can be increased when Proparacaine is combined with Difenoxin.Approved, Illicit
DihydrocodeineThe risk or severity of adverse effects can be increased when Proparacaine is combined with Dihydrocodeine.Approved, Illicit
DihydroetorphineThe risk or severity of adverse effects can be increased when Proparacaine is combined with Dihydroetorphine.Experimental, Illicit
DihydromorphineThe risk or severity of adverse effects can be increased when Proparacaine is combined with Dihydromorphine.Experimental, Illicit
DimenhydrinateThe risk or severity of adverse effects can be increased when Proparacaine is combined with Dimenhydrinate.Approved
DiphenhydramineThe risk or severity of adverse effects can be increased when Proparacaine is combined with Diphenhydramine.Approved
DiphenoxylateThe risk or severity of adverse effects can be increased when Proparacaine is combined with Diphenoxylate.Approved, Illicit
DoramectinThe risk or severity of adverse effects can be increased when Proparacaine is combined with Doramectin.Vet Approved
DoxepinThe risk or severity of adverse effects can be increased when Proparacaine is combined with Doxepin.Approved
DoxylamineDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Proparacaine.Approved, Vet Approved
DPDPEThe risk or severity of adverse effects can be increased when Proparacaine is combined with DPDPE.Investigational
DronabinolDronabinol may increase the central nervous system depressant (CNS depressant) activities of Proparacaine.Approved, Illicit
DroperidolDroperidol may increase the central nervous system depressant (CNS depressant) activities of Proparacaine.Approved, Vet Approved
DrotebanolThe risk or severity of adverse effects can be increased when Proparacaine is combined with Drotebanol.Experimental, Illicit
DuloxetineThe risk or severity of adverse effects can be increased when Proparacaine is combined with Duloxetine.Approved
DyclonineThe risk or severity of adverse effects can be increased when Dyclonine is combined with Proparacaine.Approved
EcgonineThe risk or severity of adverse effects can be increased when Proparacaine is combined with Ecgonine.Experimental, Illicit
ECGONINE METHYL ESTERThe risk or severity of adverse effects can be increased when Proparacaine is combined with ECGONINE METHYL ESTER.Experimental
EcopipamThe risk or severity of adverse effects can be increased when Proparacaine is combined with Ecopipam.Investigational
EfavirenzThe risk or severity of adverse effects can be increased when Proparacaine is combined with Efavirenz.Approved, Investigational
EnfluraneThe risk or severity of adverse effects can be increased when Enflurane is combined with Proparacaine.Approved, Vet Approved
EntacaponeThe risk or severity of adverse effects can be increased when Proparacaine is combined with Entacapone.Approved, Investigational
EscitalopramThe risk or severity of adverse effects can be increased when Proparacaine is combined with Escitalopram.Approved, Investigational
EstazolamThe risk or severity of adverse effects can be increased when Proparacaine is combined with Estazolam.Approved, Illicit
EszopicloneThe risk or severity of adverse effects can be increased when Eszopiclone is combined with Proparacaine.Approved
EthanolProparacaine may increase the central nervous system depressant (CNS depressant) activities of Ethanol.Approved
EthchlorvynolThe risk or severity of adverse effects can be increased when Ethchlorvynol is combined with Proparacaine.Approved, Illicit, Withdrawn
EthosuximideThe risk or severity of adverse effects can be increased when Proparacaine is combined with Ethosuximide.Approved
EthotoinThe risk or severity of adverse effects can be increased when Proparacaine is combined with Ethotoin.Approved
Ethyl carbamateThe risk or severity of adverse effects can be increased when Proparacaine is combined with Ethyl carbamate.Withdrawn
Ethyl loflazepateThe risk or severity of adverse effects can be increased when Proparacaine is combined with Ethyl loflazepate.Approved, Illicit
EthylmorphineThe risk or severity of adverse effects can be increased when Proparacaine is combined with Ethylmorphine.Approved, Illicit
EtidocaineThe risk or severity of adverse effects can be increased when Proparacaine is combined with Etidocaine.Approved
EtifoxineThe risk or severity of adverse effects can be increased when Proparacaine is combined with Etifoxine.Withdrawn
EtizolamThe risk or severity of adverse effects can be increased when Proparacaine is combined with Etizolam.Approved
EtomidateThe risk or severity of adverse effects can be increased when Etomidate is combined with Proparacaine.Approved
EtoperidoneThe risk or severity of adverse effects can be increased when Proparacaine is combined with Etoperidone.Approved
EtorphineThe risk or severity of adverse effects can be increased when Proparacaine is combined with Etorphine.Illicit, Vet Approved
EzogabineThe risk or severity of adverse effects can be increased when Proparacaine is combined with Ezogabine.Approved
FelbamateThe risk or severity of adverse effects can be increased when Proparacaine is combined with Felbamate.Approved
FencamfamineThe risk or severity of adverse effects can be increased when Proparacaine is combined with Fencamfamine.Approved, Illicit, Withdrawn
FentanylThe risk or severity of adverse effects can be increased when Proparacaine is combined with Fentanyl.Approved, Illicit, Investigational, Vet Approved
FexofenadineThe risk or severity of adverse effects can be increased when Proparacaine is combined with Fexofenadine.Approved
FlibanserinThe risk or severity of adverse effects can be increased when Proparacaine is combined with Flibanserin.Approved
FludiazepamThe risk or severity of adverse effects can be increased when Proparacaine is combined with Fludiazepam.Approved, Illicit
FlunarizineThe risk or severity of adverse effects can be increased when Proparacaine is combined with Flunarizine.Approved
FlunitrazepamThe risk or severity of adverse effects can be increased when Proparacaine is combined with Flunitrazepam.Approved, Illicit
FluoxetineThe risk or severity of adverse effects can be increased when Proparacaine is combined with Fluoxetine.Approved, Vet Approved
FlupentixolThe risk or severity of adverse effects can be increased when Proparacaine is combined with Flupentixol.Approved, Withdrawn
FluphenazineThe risk or severity of adverse effects can be increased when Fluphenazine is combined with Proparacaine.Approved
FlurazepamThe risk or severity of adverse effects can be increased when Flurazepam is combined with Proparacaine.Approved, Illicit
FluspirileneThe risk or severity of adverse effects can be increased when Proparacaine is combined with Fluspirilene.Approved
Fluticasone PropionateThe risk or severity of adverse effects can be increased when Proparacaine is combined with Fluticasone Propionate.Approved
FluvoxamineThe risk or severity of adverse effects can be increased when Fluvoxamine is combined with Proparacaine.Approved, Investigational
FosphenytoinThe risk or severity of adverse effects can be increased when Proparacaine is combined with Fosphenytoin.Approved
FospropofolThe risk or severity of adverse effects can be increased when Proparacaine is combined with Fospropofol.Approved, Illicit
GabapentinThe risk or severity of adverse effects can be increased when Proparacaine is combined with Gabapentin.Approved, Investigational
gabapentin enacarbilThe risk or severity of adverse effects can be increased when Proparacaine is combined with gabapentin enacarbil.Approved
Gamma Hydroxybutyric AcidThe risk or severity of adverse effects can be increased when Proparacaine is combined with Gamma Hydroxybutyric Acid.Approved, Illicit
GepironeThe risk or severity of adverse effects can be increased when Proparacaine is combined with Gepirone.Investigational
GlutethimideThe risk or severity of adverse effects can be increased when Proparacaine is combined with Glutethimide.Approved, Illicit
GuanfacineThe risk or severity of adverse effects can be increased when Proparacaine is combined with Guanfacine.Approved, Investigational
HalazepamThe risk or severity of adverse effects can be increased when Halazepam is combined with Proparacaine.Approved, Illicit, Withdrawn
HaloperidolThe risk or severity of adverse effects can be increased when Haloperidol is combined with Proparacaine.Approved
HalothaneThe risk or severity of adverse effects can be increased when Proparacaine is combined with Halothane.Approved, Vet Approved
HeroinThe risk or severity of adverse effects can be increased when Proparacaine is combined with Heroin.Approved, Illicit
HexobarbitalThe risk or severity of adverse effects can be increased when Proparacaine is combined with Hexobarbital.Approved
HyaluronidaseThe risk or severity of adverse effects can be increased when Hyaluronidase is combined with Proparacaine.Approved, Investigational
HydrocodoneProparacaine may increase the central nervous system depressant (CNS depressant) activities of Hydrocodone.Approved, Illicit
HydromorphoneThe risk or severity of adverse effects can be increased when Hydromorphone is combined with Proparacaine.Approved, Illicit
HydroxyzineHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Proparacaine.Approved
IloperidoneThe risk or severity of adverse effects can be increased when Proparacaine is combined with Iloperidone.Approved
ImipramineThe risk or severity of adverse effects can be increased when Proparacaine is combined with Imipramine.Approved
IndalpineThe risk or severity of adverse effects can be increased when Proparacaine is combined with Indalpine.Investigational, Withdrawn
IsofluraneThe risk or severity of adverse effects can be increased when Isoflurane is combined with Proparacaine.Approved, Vet Approved
KetamineThe risk or severity of adverse effects can be increased when Proparacaine is combined with Ketamine.Approved, Vet Approved
KetazolamThe risk or severity of adverse effects can be increased when Proparacaine is combined with Ketazolam.Approved
KetobemidoneThe risk or severity of adverse effects can be increased when Proparacaine is combined with Ketobemidone.Approved
LamotrigineThe risk or severity of adverse effects can be increased when Proparacaine is combined with Lamotrigine.Approved, Investigational
LevetiracetamThe risk or severity of adverse effects can be increased when Proparacaine is combined with Levetiracetam.Approved, Investigational
LevobupivacaineThe risk or severity of adverse effects can be increased when Proparacaine is combined with Levobupivacaine.Approved
LevocabastineThe risk or severity of adverse effects can be increased when Proparacaine is combined with Levocabastine.Approved
LevocetirizineThe risk or severity of adverse effects can be increased when Proparacaine is combined with Levocetirizine.Approved
LevodopaThe risk or severity of adverse effects can be increased when Proparacaine is combined with Levodopa.Approved
Levomethadyl AcetateThe risk or severity of adverse effects can be increased when Proparacaine is combined with Levomethadyl Acetate.Approved
LevomilnacipranThe risk or severity of adverse effects can be increased when Proparacaine is combined with Levomilnacipran.Approved
LevorphanolThe risk or severity of adverse effects can be increased when Proparacaine is combined with Levorphanol.Approved
LidocaineThe risk or severity of adverse effects can be increased when Lidocaine is combined with Proparacaine.Approved, Vet Approved
LithiumThe risk or severity of adverse effects can be increased when Proparacaine is combined with Lithium.Approved
LofentanilThe risk or severity of adverse effects can be increased when Proparacaine is combined with Lofentanil.Illicit
LoratadineThe risk or severity of adverse effects can be increased when Proparacaine is combined with Loratadine.Approved
LorazepamThe risk or severity of adverse effects can be increased when Lorazepam is combined with Proparacaine.Approved
LoxapineThe risk or severity of adverse effects can be increased when Loxapine is combined with Proparacaine.Approved
Lu AA21004The risk or severity of adverse effects can be increased when Proparacaine is combined with Lu AA21004.Investigational
LurasidoneThe risk or severity of adverse effects can be increased when Proparacaine is combined with Lurasidone.Approved
Magnesium SulfateMagnesium Sulfate may increase the central nervous system depressant (CNS depressant) activities of Proparacaine.Approved, Vet Approved
MaprotilineThe risk or severity of adverse effects can be increased when Proparacaine is combined with Maprotiline.Approved
MeclizineThe risk or severity of adverse effects can be increased when Proparacaine is combined with Meclizine.Approved
MedetomidineThe risk or severity of adverse effects can be increased when Proparacaine is combined with Medetomidine.Vet Approved
MelatoninThe risk or severity of adverse effects can be increased when Proparacaine is combined with Melatonin.Approved, Nutraceutical, Vet Approved
MelperoneThe risk or severity of adverse effects can be increased when Proparacaine is combined with Melperone.Approved
MepivacaineThe risk or severity of adverse effects can be increased when Proparacaine is combined with Mepivacaine.Approved, Vet Approved
MeprobamateThe risk or severity of adverse effects can be increased when Meprobamate is combined with Proparacaine.Approved, Illicit
MesoridazineThe risk or severity of adverse effects can be increased when Proparacaine is combined with Mesoridazine.Approved
MetaxaloneThe risk or severity of adverse effects can be increased when Proparacaine is combined with Metaxalone.Approved
MethadoneThe risk or severity of adverse effects can be increased when Methadone is combined with Proparacaine.Approved
Methadyl AcetateThe risk or severity of adverse effects can be increased when Proparacaine is combined with Methadyl Acetate.Approved, Illicit
MethapyrileneThe risk or severity of adverse effects can be increased when Proparacaine is combined with Methapyrilene.Withdrawn
MethaqualoneThe risk or severity of adverse effects can be increased when Proparacaine is combined with Methaqualone.Illicit, Withdrawn
MethocarbamolThe risk or severity of adverse effects can be increased when Proparacaine is combined with Methocarbamol.Approved, Vet Approved
MethohexitalThe risk or severity of adverse effects can be increased when Methohexital is combined with Proparacaine.Approved
MethotrimeprazineProparacaine may increase the central nervous system depressant (CNS depressant) activities of Methotrimeprazine.Approved
MethoxyfluraneThe risk or severity of adverse effects can be increased when Proparacaine is combined with Methoxyflurane.Approved, Vet Approved
MethsuximideThe risk or severity of adverse effects can be increased when Proparacaine is combined with Methsuximide.Approved
MethylphenobarbitalThe risk or severity of adverse effects can be increased when Proparacaine is combined with Methylphenobarbital.Approved
MetyrosineProparacaine may increase the sedative activities of Metyrosine.Approved
MidazolamThe risk or severity of adverse effects can be increased when Midazolam is combined with Proparacaine.Approved, Illicit
MilnacipranThe risk or severity of adverse effects can be increased when Proparacaine is combined with Milnacipran.Approved
MinocyclineMinocycline may increase the central nervous system depressant (CNS depressant) activities of Proparacaine.Approved, Investigational
MirtazapineProparacaine may increase the central nervous system depressant (CNS depressant) activities of Mirtazapine.Approved
MolindoneThe risk or severity of adverse effects can be increased when Proparacaine is combined with Molindone.Approved
MorphineThe risk or severity of adverse effects can be increased when Morphine is combined with Proparacaine.Approved, Investigational
NabiloneNabilone may increase the central nervous system depressant (CNS depressant) activities of Proparacaine.Approved, Investigational
NalbuphineThe risk or severity of adverse effects can be increased when Proparacaine is combined with Nalbuphine.Approved
NefazodoneThe risk or severity of adverse effects can be increased when Proparacaine is combined with Nefazodone.Approved, Withdrawn
NitrazepamThe risk or severity of adverse effects can be increased when Proparacaine is combined with Nitrazepam.Approved
Nitrous oxideThe risk or severity of adverse effects can be increased when Proparacaine is combined with Nitrous oxide.Approved, Vet Approved
NormethadoneThe risk or severity of adverse effects can be increased when Proparacaine is combined with Normethadone.Approved, Illicit
NortriptylineThe risk or severity of adverse effects can be increased when Proparacaine is combined with Nortriptyline.Approved
OlanzapineThe risk or severity of adverse effects can be increased when Olanzapine is combined with Proparacaine.Approved, Investigational
OlopatadineThe risk or severity of adverse effects can be increased when Proparacaine is combined with Olopatadine.Approved
OndansetronThe risk or severity of adverse effects can be increased when Proparacaine is combined with Ondansetron.Approved
OpiumThe risk or severity of adverse effects can be increased when Proparacaine is combined with Opium.Approved, Illicit
OrphenadrineProparacaine may increase the central nervous system depressant (CNS depressant) activities of Orphenadrine.Approved
OsanetantThe risk or severity of adverse effects can be increased when Proparacaine is combined with Osanetant.Investigational
OxazepamThe risk or severity of adverse effects can be increased when Proparacaine is combined with Oxazepam.Approved
OxetacaineThe risk or severity of adverse effects can be increased when Proparacaine is combined with Oxetacaine.Investigational
OxprenololThe risk or severity of adverse effects can be increased when Proparacaine is combined with Oxprenolol.Approved
OxybuprocaineThe risk or severity of adverse effects can be increased when Proparacaine is combined with Oxybuprocaine.Approved
OxycodoneThe risk or severity of adverse effects can be increased when Oxycodone is combined with Proparacaine.Approved, Illicit, Investigational
OxymorphoneThe risk or severity of adverse effects can be increased when Proparacaine is combined with Oxymorphone.Approved, Investigational, Vet Approved
PaliperidoneThe risk or severity of adverse effects can be increased when Proparacaine is combined with Paliperidone.Approved
ParaldehydeProparacaine may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.Approved
ParoxetineThe risk or severity of adverse effects can be increased when Proparacaine is combined with Paroxetine.Approved, Investigational
PentazocineThe risk or severity of adverse effects can be increased when Pentazocine is combined with Proparacaine.Approved, Vet Approved
PentobarbitalThe risk or severity of adverse effects can be increased when Pentobarbital is combined with Proparacaine.Approved, Vet Approved
PerampanelPerampanel may increase the central nervous system depressant (CNS depressant) activities of Proparacaine.Approved
PerazineThe risk or severity of adverse effects can be increased when Proparacaine is combined with Perazine.Investigational
PerospironeThe risk or severity of adverse effects can be increased when Proparacaine is combined with Perospirone.Approved
PerphenazineThe risk or severity of adverse effects can be increased when Proparacaine is combined with Perphenazine.Approved
PethidineThe risk or severity of adverse effects can be increased when Pethidine is combined with Proparacaine.Approved
PhenobarbitalThe risk or severity of adverse effects can be increased when Proparacaine is combined with Phenobarbital.Approved
PhenoxyethanolThe risk or severity of adverse effects can be increased when Proparacaine is combined with Phenoxyethanol.Approved
PhenytoinThe risk or severity of adverse effects can be increased when Proparacaine is combined with Phenytoin.Approved, Vet Approved
PimozideThe risk or severity of adverse effects can be increased when Proparacaine is combined with Pimozide.Approved
PipamperoneThe risk or severity of adverse effects can be increased when Proparacaine is combined with Pipamperone.Approved
PipotiazineThe risk or severity of adverse effects can be increased when Proparacaine is combined with Pipotiazine.Approved
PiritramideThe risk or severity of adverse effects can be increased when Proparacaine is combined with Piritramide.Investigational
PizotifenThe risk or severity of adverse effects can be increased when Proparacaine is combined with Pizotifen.Approved
PomalidomideThe risk or severity of adverse effects can be increased when Proparacaine is combined with Pomalidomide.Approved
PramipexoleProparacaine may increase the sedative activities of Pramipexole.Approved, Investigational
PramocaineThe risk or severity of adverse effects can be increased when Proparacaine is combined with Pramocaine.Approved
PrazepamThe risk or severity of adverse effects can be increased when Proparacaine is combined with Prazepam.Approved, Illicit
PregabalinThe risk or severity of adverse effects can be increased when Pregabalin is combined with Proparacaine.Approved, Illicit, Investigational
PregnanoloneThe risk or severity of adverse effects can be increased when Proparacaine is combined with Pregnanolone.Investigational
PrilocaineThe risk or severity of adverse effects can be increased when Prilocaine is combined with Proparacaine.Approved
PrimidoneThe risk or severity of adverse effects can be increased when Proparacaine is combined with Primidone.Approved, Vet Approved
ProcaineThe risk or severity of adverse effects can be increased when Procaine is combined with Proparacaine.Approved, Investigational, Vet Approved
ProchlorperazineThe risk or severity of adverse effects can be increased when Prochlorperazine is combined with Proparacaine.Approved, Vet Approved
PromazineThe risk or severity of adverse effects can be increased when Promazine is combined with Proparacaine.Approved, Vet Approved
PromethazineThe risk or severity of adverse effects can be increased when Proparacaine is combined with Promethazine.Approved
PropofolThe risk or severity of adverse effects can be increased when Proparacaine is combined with Propofol.Approved, Investigational, Vet Approved
PropoxycaineThe risk or severity of adverse effects can be increased when Proparacaine is combined with Propoxycaine.Approved
ProtriptylineThe risk or severity of adverse effects can be increased when Proparacaine is combined with Protriptyline.Approved
PSD502The risk or severity of adverse effects can be increased when Proparacaine is combined with PSD502.Investigational
QuazepamThe risk or severity of adverse effects can be increased when Proparacaine is combined with Quazepam.Approved, Illicit
QuetiapineThe risk or severity of adverse effects can be increased when Proparacaine is combined with Quetiapine.Approved
RacloprideThe risk or severity of adverse effects can be increased when Proparacaine is combined with Raclopride.Investigational
RamelteonThe risk or severity of adverse effects can be increased when Proparacaine is combined with Ramelteon.Approved, Investigational
RemifentanilThe risk or severity of adverse effects can be increased when Proparacaine is combined with Remifentanil.Approved
RemoxiprideThe risk or severity of adverse effects can be increased when Remoxipride is combined with Proparacaine.Approved, Withdrawn
ReserpineThe risk or severity of adverse effects can be increased when Reserpine is combined with Proparacaine.Approved
RisperidoneThe risk or severity of adverse effects can be increased when Risperidone is combined with Proparacaine.Approved, Investigational
RitanserinThe risk or severity of adverse effects can be increased when Proparacaine is combined with Ritanserin.Investigational
RomifidineThe risk or severity of adverse effects can be increased when Proparacaine is combined with Romifidine.Vet Approved
RopiniroleProparacaine may increase the sedative activities of Ropinirole.Approved, Investigational
RopivacaineThe risk or severity of adverse effects can be increased when Ropivacaine is combined with Proparacaine.Approved
RotigotineProparacaine may increase the sedative activities of Rotigotine.Approved
RufinamideThe risk or severity of adverse effects can be increased when Rufinamide is combined with Proparacaine.Approved
S-EthylisothioureaThe risk or severity of adverse effects can be increased when Proparacaine is combined with S-Ethylisothiourea.Experimental
Sage 547The risk or severity of adverse effects can be increased when Proparacaine is combined with Sage 547.Investigational
ScopolamineThe risk or severity of adverse effects can be increased when Proparacaine is combined with Scopolamine.Approved
SecobarbitalThe risk or severity of adverse effects can be increased when Secobarbital is combined with Proparacaine.Approved, Vet Approved
SertindoleThe risk or severity of adverse effects can be increased when Proparacaine is combined with Sertindole.Approved, Withdrawn
SertralineThe risk or severity of adverse effects can be increased when Proparacaine is combined with Sertraline.Approved
SevofluraneThe risk or severity of adverse effects can be increased when Proparacaine is combined with Sevoflurane.Approved, Vet Approved
Sodium oxybateSodium oxybate may increase the central nervous system depressant (CNS depressant) activities of Proparacaine.Approved
StiripentolThe risk or severity of adverse effects can be increased when Proparacaine is combined with Stiripentol.Approved
SufentanilThe risk or severity of adverse effects can be increased when Sufentanil is combined with Proparacaine.Approved, Investigational
SulpirideThe risk or severity of adverse effects can be increased when Sulpiride is combined with Proparacaine.Approved
SuvorexantProparacaine may increase the central nervous system depressant (CNS depressant) activities of Suvorexant.Approved
TandospironeThe risk or severity of adverse effects can be increased when Proparacaine is combined with Tandospirone.Investigational
TapentadolTapentadol may increase the central nervous system depressant (CNS depressant) activities of Proparacaine.Approved
TasimelteonThe risk or severity of adverse effects can be increased when Proparacaine is combined with Tasimelteon.Approved
Technetium Tc-99m tilmanoceptProparacaine may decrease effectiveness of Technetium Tc-99m tilmanocept as a diagnostic agent.Approved
TemazepamThe risk or severity of adverse effects can be increased when Temazepam is combined with Proparacaine.Approved
TetrabenazineThe risk or severity of adverse effects can be increased when Proparacaine is combined with Tetrabenazine.Approved
TetracaineThe risk or severity of adverse effects can be increased when Proparacaine is combined with Tetracaine.Approved, Vet Approved
TetrodotoxinThe risk or severity of adverse effects can be increased when Proparacaine is combined with Tetrodotoxin.Investigational
ThalidomideProparacaine may increase the central nervous system depressant (CNS depressant) activities of Thalidomide.Approved, Investigational, Withdrawn
ThiamylalThe risk or severity of adverse effects can be increased when Proparacaine is combined with Thiamylal.Approved, Vet Approved
ThiopentalThe risk or severity of adverse effects can be increased when Thiopental is combined with Proparacaine.Approved, Vet Approved
ThioridazineThe risk or severity of adverse effects can be increased when Thioridazine is combined with Proparacaine.Approved
ThiothixeneThe risk or severity of adverse effects can be increased when Proparacaine is combined with Thiothixene.Approved
TiagabineThe risk or severity of adverse effects can be increased when Proparacaine is combined with Tiagabine.Approved
TiaprideThe risk or severity of adverse effects can be increased when Proparacaine is combined with Tiapride.Investigational
TiletamineThe risk or severity of adverse effects can be increased when Proparacaine is combined with Tiletamine.Vet Approved
TizanidineThe risk or severity of adverse effects can be increased when Proparacaine is combined with Tizanidine.Approved
TolcaponeThe risk or severity of adverse effects can be increased when Proparacaine is combined with Tolcapone.Approved, Withdrawn
TopiramateThe risk or severity of adverse effects can be increased when Proparacaine is combined with Topiramate.Approved
TramadolThe risk or severity of adverse effects can be increased when Tramadol is combined with Proparacaine.Approved, Investigational
Trans-2-PhenylcyclopropylamineThe risk or severity of adverse effects can be increased when Proparacaine is combined with Trans-2-Phenylcyclopropylamine.Experimental
TranylcypromineThe risk or severity of adverse effects can be increased when Tranylcypromine is combined with Proparacaine.Approved
TrazodoneThe risk or severity of adverse effects can be increased when Trazodone is combined with Proparacaine.Approved, Investigational
TriazolamThe risk or severity of adverse effects can be increased when Proparacaine is combined with Triazolam.Approved
TrifluoperazineThe risk or severity of adverse effects can be increased when Proparacaine is combined with Trifluoperazine.Approved
TriflupromazineThe risk or severity of adverse effects can be increased when Triflupromazine is combined with Proparacaine.Approved, Vet Approved
TrimipramineThe risk or severity of adverse effects can be increased when Proparacaine is combined with Trimipramine.Approved
TriprolidineThe risk or severity of adverse effects can be increased when Proparacaine is combined with Triprolidine.Approved
Uc1010The risk or severity of adverse effects can be increased when Proparacaine is combined with Uc1010.Investigational
Valproic AcidThe risk or severity of adverse effects can be increased when Valproic Acid is combined with Proparacaine.Approved, Investigational
VenlafaxineThe risk or severity of adverse effects can be increased when Proparacaine is combined with Venlafaxine.Approved
VigabatrinThe risk or severity of adverse effects can be increased when Proparacaine is combined with Vigabatrin.Approved
VortioxetineThe risk or severity of adverse effects can be increased when Proparacaine is combined with Vortioxetine.Approved
XylazineThe risk or severity of adverse effects can be increased when Proparacaine is combined with Xylazine.Vet Approved
ZaleplonThe risk or severity of adverse effects can be increased when Proparacaine is combined with Zaleplon.Approved, Illicit, Investigational
ZiconotideThe risk or severity of adverse effects can be increased when Proparacaine is combined with Ziconotide.Approved
ZimelidineThe risk or severity of adverse effects can be increased when Proparacaine is combined with Zimelidine.Withdrawn
ZiprasidoneThe risk or severity of adverse effects can be increased when Ziprasidone is combined with Proparacaine.Approved
ZolazepamThe risk or severity of adverse effects can be increased when Proparacaine is combined with Zolazepam.Vet Approved
ZolpidemProparacaine may increase the central nervous system depressant (CNS depressant) activities of Zolpidem.Approved
ZonisamideThe risk or severity of adverse effects can be increased when Proparacaine is combined with Zonisamide.Approved, Investigational
ZopicloneThe risk or severity of adverse effects can be increased when Proparacaine is combined with Zopiclone.Approved
ZotepineThe risk or severity of adverse effects can be increased when Proparacaine is combined with Zotepine.Approved
ZuclopenthixolThe risk or severity of adverse effects can be increased when Proparacaine is combined with Zuclopenthixol.Approved, Investigational
Food InteractionsNot Available
References
Synthesis ReferenceNot Available
General ReferencesNot Available
External Links
ATC CodesS01HA04
AHFS CodesNot Available
PDB EntriesNot Available
FDA labelDownload (118 KB)
MSDSDownload (73.7 KB)
ADMET
Predicted ADMET features
PropertyValueProbability
Human Intestinal Absorption+0.9769
Blood Brain Barrier+0.8876
Caco-2 permeable+0.6501
P-glycoprotein substrateSubstrate0.7085
P-glycoprotein inhibitor INon-inhibitor0.7586
P-glycoprotein inhibitor IINon-inhibitor0.9645
Renal organic cation transporterNon-inhibitor0.7172
CYP450 2C9 substrateNon-substrate0.8202
CYP450 2D6 substrateNon-substrate0.5953
CYP450 3A4 substrateSubstrate0.5624
CYP450 1A2 substrateInhibitor0.9107
CYP450 2C9 inhibitorNon-inhibitor0.9093
CYP450 2D6 inhibitorInhibitor0.8932
CYP450 2C19 inhibitorNon-inhibitor0.9025
CYP450 3A4 inhibitorNon-inhibitor0.831
CYP450 inhibitory promiscuityLow CYP Inhibitory Promiscuity0.5247
Ames testNon AMES toxic0.7542
CarcinogenicityNon-carcinogens0.7336
BiodegradationNot ready biodegradable0.9764
Rat acute toxicity2.5543 LD50, mol/kg Not applicable
hERG inhibition (predictor I)Weak inhibitor0.8356
hERG inhibition (predictor II)Non-inhibitor0.5406
ADMET data is predicted using admetSAR, a free tool for evaluating chemical ADMET properties. (23092397 )
Pharmacoeconomics
Manufacturers
  • Alcon laboratories inc
  • Pharmafair inc
  • Apothecon inc div bristol myers squibb
  • Allergan pharmaceutical
  • Optopics laboratories corp
  • Bausch and lomb pharmaceuticals inc
  • Sola barnes hind
  • Taylor pharmacal co
Packagers
Dosage forms
FormRouteStrength
Solution / dropsOphthalmic0.5 %
LiquidOphthalmic; Topical0.5 %
Solution / dropsOphthalmic
SolutionOphthalmic
SolutionOphthalmic; Topical.5 %
Solution / dropsOphthalmic.5 %
SolutionOphthalmic5 mg/mL
Solution / dropsOphthalmic5 mg/mL
Solution / dropsOphthalmic5 mg
Prices
Unit descriptionCostUnit
Proparacaine hcl powder84.0USD g
Proparacaine HCl 0.5% Solution 15ml Bottle14.99USD bottle
Alcaine 0.5% eye drops2.19USD ml
Proparacaine 0.5% eye drops1.27USD ml
Ophthetic 0.5% eye drops1.02USD ml
Alcaine 0.5 % Solution0.68USD ml
DrugBank does not sell nor buy drugs. Pricing information is supplied for informational purposes only.
PatentsNot Available
Properties
StateSolid
Experimental Properties
PropertyValueSource
melting point182-183.3 °CNot Available
water solubilitySolubleNot Available
logP2.5Not Available
pKa3.2Not Available
Predicted Properties
PropertyValueSource
Water Solubility1.39 mg/mLALOGPS
logP2.97ALOGPS
logP2.6ChemAxon
logS-2.3ALOGPS
pKa (Strongest Basic)8.96ChemAxon
Physiological Charge1ChemAxon
Hydrogen Acceptor Count4ChemAxon
Hydrogen Donor Count1ChemAxon
Polar Surface Area64.79 Å2ChemAxon
Rotatable Bond Count10ChemAxon
Refractivity86.04 m3·mol-1ChemAxon
Polarizability34 Å3ChemAxon
Number of Rings1ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleYesChemAxon
Spectra
Mass Spec (NIST)Not Available
Spectra
Spectrum TypeDescriptionSplash Key
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, PositiveNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, PositiveNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, PositiveNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, NegativeNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, NegativeNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, NegativeNot Available
Taxonomy
DescriptionThis compound belongs to the class of organic compounds known as benzoic acid esters. These are ester derivatives of benzoic acid.
KingdomOrganic compounds
Super ClassBenzenoids
ClassBenzene and substituted derivatives
Sub ClassBenzoic acids and derivatives
Direct ParentBenzoic acid esters
Alternative Parents
Substituents
  • Benzoate ester
  • Aminobenzoic acid or derivatives
  • Benzylether
  • Substituted aniline
  • Phenol ether
  • Benzoyl
  • Aniline
  • Alkyl aryl ether
  • Primary aromatic amine
  • Tertiary aliphatic amine
  • Tertiary amine
  • Carboxylic acid ester
  • Monocarboxylic acid or derivatives
  • Ether
  • Carboxylic acid derivative
  • Hydrocarbon derivative
  • Primary amine
  • Organooxygen compound
  • Organonitrogen compound
  • Carbonyl group
  • Amine
  • Aromatic homomonocyclic compound
Molecular FrameworkAromatic homomonocyclic compounds
External DescriptorsNot Available

Targets

Kind
Protein
Organism
Human
Pharmacological action
yes
Actions
inhibitor
General Function:
Voltage-gated sodium channel activity
Specific Function:
Tetrodotoxin-resistant channel that mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which sodium ions may pass in accordance with their electrochemical gradient. Plays a role in neuropathic pain mechanisms.
Gene Name:
SCN10A
Uniprot ID:
Q9Y5Y9
Molecular Weight:
220623.605 Da
References
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284 ]
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423 ]
  3. Tella SR, Goldberg SR: Monoamine transporter and sodium channel mechanisms in the rapid pressor response to cocaine. Pharmacol Biochem Behav. 1998 Feb;59(2):305-12. [PubMed:9476974 ]
Comments
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Drug created on June 13, 2005 07:24 / Updated on December 04, 2016 14:48